P. Zhao

发表

Predicting Drug–Drug Interactions: An FDA Perspective

Shiew-Mei Huang, Lei Zhang, Yuanchao Zhang, 2009, The AAPS Journal.

Bioavailability Considerations in Evaluating Drug‐Drug Interactions Using the Population Pharmacokinetic Approach

P. Zhao, A. Jackson, J. Duan, 2011, Journal of clinical pharmacology.

Use of Physiologically Based Pharmacokinetic Modeling to Evaluate the Effect of Chronic Kidney Disease on the Disposition of Hepatic CYP2C8 and OATP1B Drug Substrates

Shiew-Mei Huang, Ping Zhao, Lei Zhang, 2018, Clinical pharmacology and therapeutics.

Physiologically Based Pharmacokinetic Approach to Determine Dosing on Extracorporeal Life Support: Fluconazole in Children on ECMO

K. Brouwer, P. Zhao, J. Barrett, 2018, CPT: pharmacometrics & systems pharmacology.

PBPK Modeling of the Effect of Reduced Kidney Function on the Pharmacokinetics of Drugs Excreted Renally by Organic Anion Transporters

K. Giacomini, L. Zhang, S‐M Huang, 2018, Clinical pharmacology and therapeutics.

Evaluation of Model‐Based Prediction of Pharmacokinetics in the Renal Impairment Population

P. Zhao, K. Yee, Tamara D. Cabalu, 2018, Journal of clinical pharmacology.

Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs)

Lei Zhang, Ping Zhao, Peng Duan, 2016, European Journal of Drug Metabolism and Pharmacokinetics.

Towards Quantitation of the Effects of Renal Impairment and Probenecid Inhibition on Kidney Uptake and Efflux Transporters, Using Physiologically Based Pharmacokinetic Modelling and Simulations

Lei Zhang, Shiew-Mei Huang, Ping Zhao, 2014, Clinical Pharmacokinetics.

Evaluation of Exposure Change of Nonrenally Eliminated Drugs in Patients With Chronic Kidney Disease Using Physiologically Based Pharmacokinetic Modeling and Simulation

Shiew-Mei Huang, Yuichi Sugiyama, Ping Zhao, 2012, Journal of clinical pharmacology.

Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review

L Zhang, LJ Lesko, L. Zhang, 2011, Clinical pharmacology and therapeutics.

The Application of Physiologically Based Pharmacokinetic Modeling to Predict the Role of Drug Transporters: Scientific and Regulatory Perspectives

Lei Zhang, Vikram Sinha, Ping Zhao, 2016, Journal of clinical pharmacology.

Drug–Drug Interactions of Infectious Disease Treatments in Low‐Income Countries: A Neglected Topic?

Steven Edward Kern, P. Zhao, Jingjing Yu, 2019, Clinical pharmacology and therapeutics.

Drug interactions evaluation: an integrated part of risk assessment of therapeutics.

Shiew-Mei Huang, Ping Zhao, Shiew-Mei Huang, 2010, Toxicology and applied pharmacology.

EVALUATION OF TIME-DEPENDENT INACTIVATION OF CYP3A IN CRYOPRESERVED HUMAN HEPATOCYTES

Caroline A. Lee, P. Zhao, K. Kunze, 2005, Drug Metabolism and Disposition.

Clinical Drug-Drug Interaction Evaluations to Inform Drug Use and Enable Drug Access.

I. Zineh, Shiew-Mei Huang, Lei Zhang, 2017, Journal of pharmaceutical sciences.

Drug Disposition and Drug–Drug Interactions: Importance of First-Pass Metabolism in Gut and Liver

P. Zhao, D. Shen, C. Yeung, 2010 .

Pharmacometrics in pregnancy: An unmet need.

P. Zhao, A. Rostami-Hodjegan, J. Unadkat, 2014, Annual review of pharmacology and toxicology.

Dosing Recommendations for Quetiapine When Coadministered With HIV Protease Inhibitors

P. Zhao, M. Sampson, Paula Gish, 2018, Journal of clinical pharmacology.

Sequential Metabolism Is Responsible for Diltiazem-Induced Time-Dependent Loss of CYP3A

Caroline A. Lee, P. Zhao, K. Kunze, 2007, Drug Metabolism and Disposition.

Utilizing PBPK Modeling to Evaluate the Potential of a Significant Drug–Drug Interaction Between Clopidogrel and Dasabuvir: A Scientific Perspective

P. Zhao, I. Younis, V. Arya, 2017, Clinical pharmacology and therapeutics.

Effect of Chronic Kidney Disease on Nonrenal Elimination Pathways: A Systematic Assessment of CYP1A2, CYP2C8, CYP2C9, CYP2C19, and OATP

Shiew-Mei Huang, Lei Zhang, A. Galetin, 2017, Clinical pharmacology and therapeutics.

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.

T. Meyer, K. Giacomini, Shiew-Mei Huang, 2016, Molecular pharmaceutics.

Evaluation of Various Static and Dynamic Modeling Methods to Predict Clinical CYP3A Induction Using In Vitro CYP3A4 mRNA Induction Data

L. Zhang, R. Obach, P. Zhao, 2014, Clinical pharmacology and therapeutics.

Review: The Critical Role of Clinical Pharmacology in the Development of Biologics

P. Zhao, V. Sinha, Liang Zhao, 2015 .

Predictive Performance of Physiologically-Based Pharmacokinetic Models in Predicting Drug–Drug Interactions Involving Enzyme Modulation

P. Zhao, C. Hsueh, V. Hsu, 2018, Clinical Pharmacokinetics.

Regulatory Perspectives on Designing Pharmacokinetic Studies and Optimizing Labeling Recommendations for Patients With Chronic Kidney Disease

Shiew-Mei Huang, Lei Zhang, L. Lesko, 2012, Journal of clinical pharmacology.

Quantitative Evaluation of Pharmacokinetic Inhibition of CYP3A Substrates by Ketoconazole: A Simulation Study

Shiew-Mei Huang, Ping Zhao, Isabelle Ragueneau-Majlessi, 2009, Journal of clinical pharmacology.

Dealing with the complex drug-drug interactions: towards mechanistic models.

Ping Zhao, Nina Isoherranen, P. Zhao, 2015, Biopharmaceutics & drug disposition.

Report from the EMA workshop on qualification and reporting of physiologically based pharmacokinetic (PBPK) modeling and simulation

P. Zhao, P Zhao, 2017, CPT: pharmacometrics & systems pharmacology.

A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP2D6 and CYP1A2 Metabolized Drugs in Pregnant Women

Ping Zhao, Nina Isoherranen, Amin Rostami-Hodjegan, 2013, Drug Metabolism and Disposition.

Role of Systems Modeling in Regulatory Drug Approval

Shiew-Mei Huang, Darrell R. Abernethy, Vikram Sinha, 2016 .

The utility of modeling and simulation in drug development and regulatory review.

Shiew-Mei Huang, Ping Zhao, Yaning Wang, 2013, Journal of pharmaceutical sciences.

Application of Physiologically Based Pharmacokinetic Modeling to Predict Acetaminophen Metabolism and Pharmacokinetics in Children

J S Barrett, L. Lesko, P. Zhao, 2013, CPT: pharmacometrics & systems pharmacology.

DMD050161 801..813

P. Zhao, A. Rostami-Hodjegan, J. Unadkat, 2013 .

A Physiologically Based Pharmacokinetic Model to Predict Disposition of CYP 2 D 6 and CYP 1 A 2 Metabolized Drugs in Pregnant Women s

P. Zhao, A. Rostami-Hodjegan, J. Unadkat, 2013 .

Best Practice in the Use of Physiologically Based Pharmacokinetic Modeling and Simulation to Address Clinical Pharmacology Regulatory Questions

M Rowland, Shiew-Mei Huang, S‐M Huang, 2012, Clinical pharmacology and therapeutics.

Predictive Performance of Physiologically Based Pharmacokinetic Models for the Effect of Food on Oral Drug Absorption: Current Status

Ping Zhao, Christian Wagner, P. Zhao, 2017, CPT: pharmacometrics & systems pharmacology.

Expansion of a PBPK model to predict disposition in pregnant women of drugs cleared via multiple CYP enzymes, including CYP2B6, CYP2C9 and CYP2C19.

Ping Zhao, Amin Rostami-Hodjegan, Jashvant D Unadkat, 2014, British journal of clinical pharmacology.

FDA Approval: Ceritinib for the Treatment of Metastatic Anaplastic Lymphoma Kinase–Positive Non–Small Cell Lung Cancer

Sean Khozin, Ping Zhao, Richard Pazdur, 2015, Clinical Cancer Research.

FDA Approval: Ribociclib for the Treatment of Postmenopausal Women with Hormone Receptor–Positive, HER2-Negative Advanced or Metastatic Breast Cancer

K. Goldberg, R. Pazdur, P. Zhao, 2018, Clinical Cancer Research.

RETRACTED ARTICLE: Physcion 8-O-β-glucopyranoside exhibits anti-leukemic activity through targeting sphingolipid rheostat

P. Zhao, Wei-qing Shao, Lei Sheng, 2018, Pharmacological reports : PR.

A SIMPLE SEQUENTIAL INCUBATION METHOD FOR DECONVOLUTING THE COMPLICATED SEQUENTIAL METABOLISM OF CAPRAVIRINE IN HUMANS

P. Zhao, W. Pool, E. Wu, 2005, Drug Metabolism and Disposition.

Identification of primary and sequential bioactivation pathways of carbamazepine in human liver microsomes using liquid chromatography/tandem mass spectrometry.

P. Zhao, D. Dalvie, W. Pool, 2007, Rapid communications in mass spectrometry : RCM.

Evaluation of Capravirine as a CYP3A Probe Substrate: In Vitro and in Vivo Metabolism of Capravirine in Rats and Dogs

P. Zhao, W. Pool, E. Wu, 2007, Drug Metabolism and Disposition.

Evaluation of Capravirine as a CYP 3 A Probe Substrate : In Vitro and in Vivo Metabolism of Capravirine in Rats and Dogs

P. Zhao, W. Pool, E. Wu, 2007 .

Identification of Enzymes Responsible for Primary and Sequential Oxygenation Reactions of Capravirine in Human Liver Microsomes

P. Zhao, W. Pool, E. Wu, 2006, Drug Metabolism and Disposition.

HUMAN IN VITRO GLUTATHIONYL AND PROTEIN ADDUCTS OF CARBAMAZEPINE-10,11-EPOXIDE, A STABLE AND PHARMACOLOGICALLY ACTIVE METABOLITE OF CARBAMAZEPINE

Ping Zhao, P. Zhao, Ping Kang, 2005, Drug Metabolism and Disposition.

Regulatory Experience With Physiologically Based Pharmacokinetic Modeling for Pediatric Drug Trials

S-M Huang, S‐M Huang, P. Zhao, 2012, Clinical pharmacology and therapeutics.

A PBPK Model to Predict Disposition of CYP3A-Metabolized Drugs in Pregnant Women: Verification and Discerning the Site of CYP3A Induction

P. Zhao, A. Rostami-Hodjegan, J. Unadkat, 2012, CPT: pharmacometrics & systems pharmacology.

Physiologically Based Pharmacokinetic Modeling for Predicting the Effect of Intrinsic and Extrinsic Factors on Darunavir or Lopinavir Exposure Coadministered With Ritonavir

P. Zhao, K. Struble, C. Wagner, 2017, Journal of clinical pharmacology.

Systematic and quantitative assessment of the effect of chronic kidney disease on CYP2D6 and CYP3A4/5

I. Zineh, L. Zhang, S‐M Huang, 2016, Clinical pharmacology and therapeutics.

Multiple-pool cell lifespan models for neutropenia to assess the population pharmacodynamics of unbound paclitaxel from two formulations in cancer patients

W. Jusko, P. Zhao, H. Gelderblom, 2009, Cancer Chemotherapy and Pharmacology.

Mechanistic population pharmacokinetics of total and unbound paclitaxel for a new nanodroplet formulation versus Taxol in cancer patients

W. Jusko, P. Zhao, H. Gelderblom, 2009, Cancer Chemotherapy and Pharmacology.

Predicting the Effect of CYP3A Inducers on the Pharmacokinetics of Substrate Drugs Using Physiologically Based Pharmacokinetic (PBPK) Modeling: An Analysis of PBPK Submissions to the US FDA

Vikram Sinha, Ping Zhao, Christian Wagner, 2016, Clinical Pharmacokinetics.

Selective mitochondrial glutathione depletion by ethanol enhances acetaminophen toxicity in rat liver

P. Zhao, J. Slattery, T. Kalhorn, 2002, Hepatology.

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods.

Shiew-Mei Huang, Lei Zhang, A. Galetin, 2017, Journal of pharmaceutical sciences.

Physcion 8-O-β-glucopyranoside exhibits anti-leukemic activity through targeting sphingolipid rheostat.

P. Zhao, Wei-qing Shao, Lei Sheng, 2018 .

Organ Impairment—Drug–Drug Interaction Database: A Tool for Evaluating the Impact of Renal or Hepatic Impairment and Pharmacologic Inhibition on the Systemic Exposure of Drugs

L Li, S-M Huang, Y. Sugiyama, 2015, CPT: pharmacometrics & systems pharmacology.

Complex Drug Interactions: Significance and Evaluation

Shiew-Mei Huang, Ping Zhao, Lei Zhang, 2010 .

Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions

M. Jamei, L. Gaohua, Shiew-Mei Huang, 2014, Pharmaceutical Research.

Predicting Nonlinear Pharmacokinetics of Omeprazole Enantiomers and Racemic Drug Using Physiologically Based Pharmacokinetic Modeling and Simulation: Application to Predict Drug/Genetic Interactions

Shiew-Mei Huang, Lu Gaohua, Ping Zhao, 2014, Pharmaceutical Research.

Predicting Drug Interaction Potential With a Physiologically Based Pharmacokinetic Model: A Case Study of Telithromycin, a Time‐Dependent CYP3A Inhibitor

L Zhang, L J Lesko, S-M Huang, 2012, Clinical pharmacology and therapeutics.

Biopharmaceutics Applications of Physiologically Based Pharmacokinetic Absorption Modeling and Simulation in Regulatory Submissions to the U.S. Food and Drug Administration for New Drugs

Paul Seo, Lawrence X. Yu, Ping Zhao, 2021, The AAPS Journal.

Utility of a physiologically–based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug–drug–disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice

Shiew-Mei Huang, Ping Zhao, Lawrence J Lesko, 2012, Biopharmaceutics & drug disposition.

Physiologically Based Pharmacokinetic Modeling of Drug Transporters to Facilitate Individualized Dose Prediction.

Shiew-Mei Huang, Ping Zhao, Aleksandra Galetin, 2017, Journal of pharmaceutical sciences.

Predicting the Effect of Cytochrome P450 Inhibitors on Substrate Drugs: Analysis of Physiologically Based Pharmacokinetic Modeling Submissions to the US Food and Drug Administration

Lei Zhang, Vikram Sinha, Ping Zhao, 2014, Clinical Pharmacokinetics.

Application of Physiologically Based Pharmacokinetic (PBPK) Modeling to Support Dose Selection: Report of an FDA Public Workshop on PBPK

Shiew-Mei Huang, S‐M Huang, P. Zhao, 2015, CPT: pharmacometrics & systems pharmacology.

Pharmacometrics and Systems Pharmacology 2030

Stephen Duffull, Eric Sobie, France Mentré, 2019, Clinical pharmacology and therapeutics.

FDA Approval: Blinatumomab

R. Pazdur, P. Zhao, C. Ko, 2015, Clinical Cancer Research.

Seeing what is behind the smokescreen: A systematic review of methodological aspects of smoking interaction studies over the last three decades and implications for future clinical trials

P. Zhao, A. Rostami-Hodjegan, R. Hermann, 2023, Clinical and translational science.

Mechanistic Models as Framework for Understanding Biomarker Disposition: Prediction of Creatinine‐Drug Interactions

Shiew-Mei Huang, Lei Zhang, A. Galetin, 2020, CPT: pharmacometrics & systems pharmacology.

PBPK Model Describes the Effects of Comedication and Genetic Polymorphism on Systemic Exposure of Drugs That Undergo Multiple Clearance Pathways

I Zineh, S-M Huang, I. Zineh, 2014, Clinical pharmacology and therapeutics.

ITC Recommendations for Transporter Kinetic Parameter Estimation and Translational Modeling of Transport‐Mediated PK and DDIs in Humans

M Jamei, M. Jamei, X. Chu, 2013, Clinical pharmacology and therapeutics.

A proposal for scientific framework enabling specific population drug dosing recommendations

N. Stockbridge, P. Zhao, J. Powell, 2015, Journal of clinical pharmacology.

Physiologically Based Pharmacokinetic Modeling: From Regulatory Science to Regulatory Policy

I Zineh, I. Zineh, P. Zhao, 2014, Clinical pharmacology and therapeutics.

Application of Physiologically‐Based Pharmacokinetic Modeling to Predict Gastric pH‐Dependent Drug–Drug Interactions for Weak Base Drugs

Lei Zhang, P. Zhao, Fang Wu, 2020, CPT: pharmacometrics & systems pharmacology.

Application of exposure bracketing to streamline the development of contraceptive products

P. Zhao, M. Milad, S. Schmidt, 2022, Contraception: X.

Use of Model-Informed Drug Development to Streamline Development of Long-Acting Products: Can these Successes Be Translated to Long-Acting Hormonal Contraceptives?

P. Zhao, P. Balimane, Hao Zhu, 2020, Annual review of pharmacology and toxicology.

Evaluation of Various Static In Vitro–In Vivo Extrapolation Models for Risk Assessment of the CYP3A Inhibition Potential of an Investigational Drug

J Snoeys, S D Hall, L Zhang, 2014, Clinical pharmacology and therapeutics.

Initiation of Antiviral Treatment in SARS‐CoV2: Modeling Viral Dynamics and Drug Properties

P. Zhao, V. Sinha, D. Rosenbloom, 2020, CPT: pharmacometrics & systems pharmacology.

20th North American ISSX Meeting

P. Zhao, J. Barrett, J. Lippert, 2016, Drug metabolism reviews.

American Society for Clinical Pharmacology and Therapeutics 2019 Annual Meeting Pre‐Conferences

Lei Zhang, P. Zhao, J. Bai, 2019, CPT: pharmacometrics & systems pharmacology.

The Effect of Uremic Solutes on the Organic Cation Transporter 2.

T. Meyer, K. Giacomini, Shiew-Mei Huang, 2017, Journal of pharmaceutical sciences.

A Novel Physiologically Based Model of Creatinine Renal Disposition to Integrate Current Knowledge of Systems Parameters and Clinical Observations

Shiew-Mei Huang, Lei Zhang, A. Galetin, 2020, CPT: pharmacometrics & systems pharmacology.

Physiologically Based Pharmacokinetic (PBPK) Modeling of Pitavastatin and Atorvastatin to Predict Drug-Drug Interactions (DDIs)

Lei Zhang, P. Zhao, P. Duan, 2017, European Journal of Drug Metabolism and Pharmacokinetics.

The use of hepatocytes in evaluating time-dependent inactivation of P450 in vivo

P. Zhao, 2008, Expert opinion on drug metabolism & toxicology.

Effects of ethanol dose and ethanol withdrawal on rat liver mitochondrial glutathione: implication of potentiated acetaminophen toxicity in alcoholics.

P. Zhao, J. Slattery, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Model‐Informed Assessment of Anti‐Infectives for Young Children in Low‐ and Middle‐Income Countries

Steven Edward Kern, P. Zhao, D. Wesche, 2019, CPT: pharmacometrics & systems pharmacology.

Identification and Quantitative Assessment of Uremic Solutes as Inhibitors of Renal Organic Anion Transporters, OAT1 and OAT3.

T. Meyer, K. Giacomini, Shiew-Mei Huang, 2016, Molecular pharmaceutics.

c hallenges in Developing e vidence-Based Drug Dosing Guidelines for a dults and c hildren r eceiving r enal r eplacement t herapy

Shiew-Mei Huang, Lei Zhang, L. Lesko, 2009 .

Drug–Drug Interactions of Infectious Disease Treatments in Low‐Income Countries: A Neglected Topic?

Steven Edward Kern, P. Zhao, Jingjing Yu, 2019, Clinical pharmacology and therapeutics.

Establishing a Multidisciplinary Framework to Study Drug‐Drug Interactions of Hormonal Contraceptives: An Invitation to Collaborate

Ayyappa Chaturvedula, Stephan Schmidt, Ping Zhao, 2018, CPT: pharmacometrics & systems pharmacology.

Utility of Model‐Based Approaches for Informing Dosing Recommendations in Specific Populations: Report From the Public AAPS Workshop

B. Corrigan, N. Stockbridge, P. Zhao, 2016, Journal of clinical pharmacology.