T. Tsuzuki

发表

Mismatch Repair Deficient Mice Show Susceptibility to Oxidative Stress-Induced Intestinal Carcinogenesis

J. Piao, Y. Nakatsu, M. Ohno, 2013, International journal of biological sciences.

8-oxoguanine causes spontaneous de novo germline mutations in mice

T. Ikemura, Y. Gondo, M. Ohno, 2014, Scientific Reports.

Activation of AMP-activated protein kinase by MAPO1 and FLCN induces apoptosis triggered by alkylated base mismatch in DNA.

Y. Nakatsu, T. Tsuzuki, M. Sekiguchi, 2012, DNA repair.

YB-1 Is Important for an Early Stage Embryonic Development

T. Tsuzuki, H. Izumi, K. Kohno, 2006, Journal of Biological Chemistry.

BTK gene targeting by homologous recombination using a helper-dependent adenovirus/adeno-associated virus hybrid vector

H. Takada, T. Hara, Y. Nakatsu, 2015, Gene Therapy.

A New Locus of Escherichia coli That Determines Sensitivity to Bacteriophage φX174

T. Tsuzuki, M. Sekiguchi, R. Munekiyo, 1979, Journal of bacteriology.

Budding Uninhibited by Benzimidazole-1 Insufficiency Prevents Acute Renal Failure in Severe Sepsis by Maintaining Anticoagulant Functions of Vascular Endothelial Cells

Y. Maehara, Y. Nakatsu, T. Tsuzuki, 2019, Shock.

ROS control in human iPS cells reveals early events in spontaneous carcinogenesis.

T. Tsuzuki, M. Sekiguchi, M. Hidaka, 2019, Carcinogenesis.

Methylnitrosourea-induced tumorigenesis in MGMT gene knockout mice.

S. Shimizu, T. Ishikawa, T. Tsuzuki, 1997, Cancer research.

Effects of target sequence and sense versus anti-sense strands on gene correction with single-stranded DNA fragments.

Y. Nakatsu, T. Tsuzuki, H. Harashima, 2008, Journal of biochemistry.

Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

S. Miyano, T. Shimamura, Atsuhiro Shimizu, 2019, Nature Communications.

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes.

T. Noda, H. Takano, T. Ishikawa, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structural organization of the mouse aspartate aminotransferase isoenzyme genes. Introns antedate the divergence of cytosolic and mitochondrial isoenzyme genes.

T. Tsuzuki, C. Setoyama, K. Shimada, 1988, Journal of molecular biology.

Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity.

K. Ihara, T. Tsuzuki, Y. Nakabeppu, 1997, Nucleic acids research.

Mouse MTH1 Protein with 8-Oxo-7,8-dihydro-2′-deoxyguanosine 5′-Triphosphatase Activity That Prevents Transversion Mutation

T. Tsuzuki, M. Sekiguchi, J. Nishida, 1995, The Journal of Biological Chemistry.

Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.

T. Tsuzuki, M. Furuichi, Y. Nakabeppu, 1994, Genomics.

Critical Role of Monocyte Chemoattractant Protein-1 Receptor CCR2 on Monocytes in Hypertension-Induced Vascular Inflammation and Remodeling

A. Takeshita, T. Tsuzuki, T. Sugaya, 2004, Circulation research.

Analysis of MTH1 gene function in mice with targeted mutagenesis.

A. Egashira, T. Tsuzuki, S. Kura, 2001, Mutation research.

A novel protein, MAPO1, that functions in apoptosis triggered by O6-methylguanine mispair in DNA

Y. Nakatsu, T. Tsuzuki, K. Komori, 2009, Oncogene.

Targeted disruption of the DNA repair methyltransferase gene renders mice hypersensitive to alkylating agent.

T. Iwakuma, S. Shimizu, T. Tsuzuki, 1996, Carcinogenesis.

High incidence of nitrosamine-induced tumorigenesis in mice lacking DNA repair methyltransferase.

T. Iwakuma, T. Ishikawa, T. Tsuzuki, 1997, Carcinogenesis.

Endogenous ROS production in early differentiation state suppresses endoderm differentiation via transient FOXC1 expression

Y. Nakatsu, M. Ohno, T. Tsuzuki, 2022, Cell death discovery.

Measles Virus Infection of SLAM (CD150) Knockin Mice Reproduces Tropism and Immunosuppression in Human Infection

T. Tsuzuki, M. Takeda, Fumio Seki, 2006, Journal of Virology.

BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality

Y. Maehara, T. Ohkusa, Y. Nakatsu, 2016, Scientific Reports.

Structure of the human prealbumin gene.

T. Tsuzuki, S. Araki, K. Shimada, 1985, The Journal of biological chemistry.

Bone Marrow–Derived Monocyte Chemoattractant Protein-1 Receptor CCR2 Is Critical in Angiotensin II–Induced Acceleration of Atherosclerosis and Aneurysm Formation in Hypercholesterolemic Mice

K. Sunagawa, A. Takeshita, T. Tsuzuki, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Structural organization of the mouse cytosolic malate dehydrogenase gene: comparison with that of the mouse mitochondrial malate dehydrogenase gene.

T. Tsuzuki, T. Joh, C. Setoyama, 1988, Journal of molecular biology.

cDNA cloning and expression of pig cytosolic aspartate aminotransferase in Escherichia coli: amino-terminal heterogeneity of expressed products and lack of its correlation with enzyme function.

H. Kagamiyama, T. Tsuzuki, S. Tanase, 1989, Biochemistry.

Regulatory regions of the mitochondrial and cytosolic isoenzyme genes participating in the malate-aspartate shuttle.

T. Tsuzuki, T. Joh, C. Setoyama, 1990, The Journal of biological chemistry.

Targeted disruption of one allele of the Y‐box binding protein‐1 (YB‐1) gene in mouse embryonic stem cells and increased sensitivity to cisplatin and mitomycin C

Y. Maehara, T. Tsuzuki, Y. Nakabeppu, 2004, Cancer science.

Lambda bacteriophage-mediated transduction of ColE1 deoxyribonucleic acid having a lambda bacteriophage-cohesive end site: selection of packageable-length deoxyribonucleic acid

T. Tsuzuki, K. Shimada, Y. Takagi, 1979, Journal of bacteriology.

Modes of actions of two types of anti-neoplastic drugs, dacarbazine and ACNU, to induce apoptosis.

Y. Nakatsu, T. Tsuzuki, M. Sekiguchi, 2007, Carcinogenesis.

Mutagenesis and carcinogenesis caused by the oxidation of nucleic acids

Teruhisa Tsuzuki, Katsumi Sakamoto, Y. Nakatsu, 2006, Biological chemistry.

Alkylation-induced apoptosis of embryonic stem cells in which the gene for DNA-repair, methyltransferase, had been disrupted by gene targeting.

T. Tsuzuki, M. Sekiguchi, H. Kawate, 1997, Carcinogenesis.

The role of P-glycoprotein in intestinal tumorigenesis: disruption of mdr1a suppresses polyp formation in ApcMin/+ mice

T. Tsuzuki, H. Kuwano, M. Kuwano, 2003 .

Familial amyloidotic polyneuropathy diagnosed by cloned human prealbumin cDNA

T. Tsuzuki, S. Araki, K. Shimada, 1986, Neurology.

Targeted disruption of the Rad51 gene leads to lethality in embryonic mice.

K. Nakao, T. Tsuzuki, K. Sakumi, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Structural organization of the human ornithine transcarbamylase gene

T. Tsuzuki, M. Takiguchi, I. Matsuda, 1988, Journal of Inherited Metabolic Disease.

Presence of potential nickel-responsive element(s) in the mouse MTH1 promoter.

T. Tsuzuki, Y. Nakabeppu, M. Sekiguchi, 2001, Annals of clinical and laboratory science.

Mutational specificity of mice defective in the MTH1 and/or the MSH2 genes.

H. Maki, M. Katsuki, A. Egashira, 2002, DNA repair.

Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

K. Hidaka, Y. Nakatsu, T. Tsuzuki, 2019, Experimental cell research.

Significance of error‐avoiding mechanisms for oxidative DNA damage in carcinogenesis

Y. Nakatsu, T. Tsuzuki, Y. Nakabeppu, 2007, Cancer science.

Orpheus recombination : a comprehensive bacteriophage system for murine targeting vector construction by transplacement.

Teruhisa Tsuzuki, Knut Woltjen, Kenichi Ito, 2008, Methods in molecular biology.

Isolation and characterization of the human ornithine transcarbamylase gene: structure of the 5'-end region.

T. Tsuzuki, M. Takiguchi, I. Matsuda, 1986, Journal of biochemistry.

Genetic interaction between hoxb-5 and hoxb-6 is revealed by nonallelic noncomplementation.

M. Capecchi, T. Tsuzuki, D. Rancourt, 1995, Genes & development.

Celecoxib and 2,5‐dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β‐catenin signaling pathway

Y. Nakatsu, T. Tsuzuki, Y. Nakabeppu, 2016, Cancer science.

Structure of the ornithine transcarbamylase (OTC) gene and DNA diagnosis of OTC deficiency.

T. Tsuzuki, I. Matsuda, K. Shimada, 1989, Clinica chimica acta; international journal of clinical chemistry.

DNA repair dysfunction in gastrointestinal tract cancers

E. Oki, A. Egashira, Y. Kakeji, 2008, Cancer science.

Presence of mitochondrial-DNA-like sequences in the human nuclear DNA.

T. Tsuzuki, H. Nomiyama, C. Setoyama, 1983, Gene.

Resveratrol and its Related Polyphenols Contribute to the Maintenance of Genome Stability

Atsuhiro Shimizu, Haruka Fujimori, Yusuke Matsuno, 2020, Scientific Reports.

Mismatch repair dependence of replication stress-associated DSB recognition and repair

Atsuhiro Shimizu, Haruka Fujimori, Yusuke Minakawa, 2019, Heliyon.

Oxidative nucleotide damage: consequences and prevention

T. Tsuzuki, M. Sekiguchi, 2002, Oncogene.

Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase

T Ishikawa, M. Katsuki, A. Egashira, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Differentiation-inducing factor-3 inhibits intestinal tumor growth in vitro and in vivo.

Y. Nakatsu, T. Tsuzuki, Y. Nakabeppu, 2015, Journal of pharmacological sciences.

DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice.

Y. Nakatsu, T. Tsuzuki, Y. Nakabeppu, 2014, Biochemical pharmacology.

MUTYH-null mice are susceptible to spontaneous and oxidative stress induced intestinal tumorigenesis.

H. Maki, A. Egashira, Y. Nakatsu, 2007, Cancer research.

Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.

T. Tsuzuki, K. Sakumi, M. Furuichi, 2003, Cancer research.

Cloning and expression of cDNA for a human enzyme that hydrolyzes 8-oxo-dGTP, a mutagenic substrate for DNA synthesis.

H. Maki, T. Tsuzuki, K. Sakumi, 1993, The Journal of biological chemistry.

Radiation Induced DNA Damage and Its Defense Mechanism

H. Maki, A. Egashira, T. Tsuzuki, 2003 .

Comprehensive behavioural study of GluR4 knockout mice: implication in cognitive function

H. Sugiyama, I. Ito, T. Tsuzuki, 2010, Genes, brain, and behavior.

Interruption of a human nuclear sequence homologous to mitochondrial DNA by a member of the KpnI 1.8 kb family

Kazunori Shimada, Hisayuki Nomiyama, Teruhisa Tsuzuki, 1984, Nucleic Acids Res..

Mitochondrial DNA-like sequences in the human nuclear genome. Characterization and implications in the evolution of mitochondrial DNA.

T. Miyata, T. Tsuzuki, M. Fukuda, 1985, Journal of molecular biology.

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

M. Ohno, T. Tsuzuki, T. Nohmi, 2021, Genes and environment : the official journal of the Japanese Environmental Mutagen Society.

Oxidative-stress-driven mutagenesis in the small intestine of the gpt delta mouse induced by oral administration of potassium bromate.

M. Ohno, T. Tsuzuki, Masayuki Yamamoto, 2020, Mutation research.

Organization and Expression of the Mouse MTH1 Gene for Preventing Transversion Mutation*

T. Tsuzuki, M. Sekiguchi, T. Kakuma, 1997, The Journal of Biological Chemistry.

Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability

E. Oki, A. Egashira, Y. Kakeji, 2005, Nucleic acids research.

Structural organization of the mouse mitochondrial malate dehydrogenase gene.

T. Tsuzuki, T. Joh, K. Shimada, 1988, Journal of molecular biology.

Structural organization of the mouse mitochondrial aspartate aminotransferase gene.

T. Tsuzuki, C. Setoyama, K. Shimada, 1987, Journal of molecular biology.

Cloning and sequence analysis of cDNAs encoding mammalian mitochondrial malate dehydrogenase.

T. Tsuzuki, S. Tanase, Y. Morino, 1987, Biochemistry.

Possible Mechanisms Underlying Genotoxic Thresholds: DNA Repair and Translesion DNA Synthesis

T. Tsuzuki, T. Nohmi, 2016 .

Correction: PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens

A. Nishi, E. Nestler, R. Neve, 2015, PloS one.

PSMC5, a 19S Proteasomal ATPase, Regulates Cocaine Action in the Nucleus Accumbens

A. Nishi, E. Nestler, R. Neve, 2015, PloS one.

PSMC 5 , a 19 S Proteasomal ATPase , Regulates Cocaine Action in the Nucleus Accumbens Citation

A. Nishi, R. Neve, M. Ohno, 2015 .

Nucleotide excision repair of oxidised genomic DNA is not a source of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine.

M. Evans, M. Bignami, D. Phillips, 2016, Free radical biology & medicine.

UV-induced mutations in epidermal cells of mice defective in DNA polymerase η and/or ι.

Y. Nakatsu, T. Tsuzuki, F. Hanaoka, 2015, DNA repair.

Structural and Dynamic Features of the MutT Protein in the Recognition of Nucleotides with the Mutagenic 8-Oxoguanine Base*

Teruya Nakamura, Y. Yamagata, T. Tsuzuki, 2009, The Journal of Biological Chemistry.

A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice.

T. Noda, T. Ishikawa, T. Tsuzuki, 2000, Carcinogenesis.

Abnormality in Wnt Signaling is Causatively Associated with Oxidative Stress-Induced Intestinal Tumorigenesis in MUTYH-Null Mice

H. Honda, J. Piao, Y. Nakatsu, 2014, International journal of biological sciences.

Knockout-associated Lung Tumorigenesis and Its Suppression by Mth 1 Gene Disruption 1

T. Tsuzuki, K. Sakumi, M. Furuichi, 2003 .

Targeted sequence alteration of a chromosomal locus in mouse liver.

J. Piao, Y. Nakatsu, T. Tsuzuki, 2010, International journal of pharmaceutics.

Improved gene correction efficiency with a tailed duplex DNA fragment.

Y. Nakatsu, T. Tsuzuki, H. Harashima, 2008, Biochemistry.

Effects of mismatches distant from the target position on gene correction with a 5'-tailed duplex.

Y. Nakatsu, T. Tsuzuki, H. Kamiya, 2018, Journal of bioscience and bioengineering.

Insertion and Deletion Mismatches Distant from the Target Position Improve Gene Correction with a Tailed Duplex

Y. Nakatsu, T. Tsuzuki, H. Harashima, 2016, Nucleosides, nucleotides & nucleic acids.

Spontaneous Tumorigenesis and Mutagenesis in Mice Defective in the MTH1 Gene

T. Tsuzuki, 2001 .

Enrichment and efficient screening of ES cells containing a targeted mutation: the use of DT‐A gene with the polyadenylation signal as a negative selection maker

T. Yagi, J. Miyazaki, F. Tashiro, 1999, Transgenic Research.

cDNA and genomic sequences for rat 8-oxo-dGTPase that prevents occurrence of spontaneous mutations due to oxidation of guanine nucleotides.

T. Tsuzuki, M. Sekiguchi, T. Kakuma, 1995, Carcinogenesis.

Prevention of radiation-induced pneumonitis by recombinant adenovirus-mediated transferring of soluble TGF-β type II receptor gene

T. Tsuzuki, Y. Nakanishi, K. Takayama, 2006, Cancer Gene Therapy.

BubR1 Insufficiency Inhibits Neointimal Hyperplasia Through Impaired Vascular Smooth Muscle Cell Proliferation in Mice

Y. Maehara, Y. Nakatsu, T. Tsuzuki, 2015, Arteriosclerosis, thrombosis, and vascular biology.

Structure of the human ornithine transcarbamylase gene.

T. Tsuzuki, M. Takiguchi, I. Matsuda, 1988, Journal of biochemistry.

ES cell neural differentiation reveals a substantial number of novel ESTs

J. E. Hance, F. C. Mansergh, D. E. Rancourt, 2000, Functional & Integrative Genomics.

Judgement on "hit or non-hit" of CHO cells exposed to accelerated heavy-ions (Fe- or Ar-ions) using division delay and CR-39 plastics as an indicator.

T. Tsuzuki, P. Mehnati, H. Sasaki, 2001, Fukuoka igaku zasshi = Hukuoka acta medica.

Oxidative stress-induced tumorigenesis in the small intestines of DNA repair-deficient mice.

J. Piao, Y. Nakatsu, T. Tsuzuki, 2011, Health physics.

BUBR1 Insufficiency in Mice Increases their Sensitivity to Oxidative Stress.

Y. Maehara, Y. Nakatsu, T. Tsuzuki, 2016, In vivo.

The majority of cDNA clones with strong positive signals for the interferon-induction-specific sequences resemble mitochondrial ribosomal RNA genes.

S. Pestka, T. Tsuzuki, H. Nomiyama, 1983, Biochemical and biophysical research communications.

The role of P-glycoprotein in intestinal tumorigenesis: disruption of mdr1a suppresses polyp formation in Apc(Min/+) mice.

T. Tsuzuki, H. Kuwano, M. Kuwano, 2003, Carcinogenesis.

Cloning and sequence analysis of cDNAs encoding mammalian cytosolic malate dehydrogenase. Comparison of the amino acid sequences of mammalian and bacterial malate dehydrogenase.

H. Kagamiyama, T. Tsuzuki, S. Tanase, 1987, The Journal of biological chemistry.