Ewa P. Malc

发表

Clustered mutations in yeast and in human cancers can arise from damaged long single-strand DNA regions.

Steven A. Roberts, P. Mieczkowski, G. Kryukov, 2012, Molecular cell.

Break-induced replication is a source of mutation clusters underlying kataegis.

Cynthia J. Sakofsky, Steven A. Roberts, P. Mieczkowski, 2014, Cell reports.

Proteogenomic Characterization of Endometrial Carcinoma

Peter B. McGarvey, Ying Wang, Li Ding, 2020, Cell.

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

Gad Getz, Kin Chan, Dmitry A. Gordenin, 2015, Nature Genetics.

Gene Copy-Number Variation in Haploid and Diploid Strains of the Yeast Saccharomyces cerevisiae

Hengshan Zhang, P. Mieczkowski, T. Petes, 2013, Genetics.

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

J. Heitman, P. Mieczkowski, Jeremy R. Wang, 2019, bioRxiv.

Long transposon-rich centromeres in an oomycete reveal divergence of centromere features in Stramenopila-Alveolata-Rhizaria lineages

J. Heitman, P. Mieczkowski, Jeremy R. Wang, 2019, bioRxiv.

Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma

Jeffrey R. Whiteaker, Dana R. Valley, Karna L. Robinson, 2020, Cell.

Metabolic potential, ecology and presence of endohyphal bacteria is reflected in genomic diversity of Mucoromycotina

P. Mieczkowski, Ewa P. Malc, A. Muszewska, 2020, bioRxiv.

Repair of oxidative damage in mitochondrial DNA of Saccharomyces cerevisiae: involvement of the MSH1-dependent pathway.

P. Koprowski, Ewa P. Malc, P. Dzierzbicki, 2004, DNA repair.

Heterogeneous polymerase fidelity and mismatch repair bias genome variation and composition

T. Kunkel, P. Mieczkowski, D. Gordenin, 2014, Genome research.

An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers

G. Getz, P. Mieczkowski, Jaegil Kim, 2015, Nature Genetics.

The generation of oxidative stress-induced rearrangements in Saccharomyces cerevisiae mtDNA is dependent on the Nuc1 (EndoG/ExoG) nuclease and is enhanced by inactivation of the MRX complex.

P. Mieczkowski, Ewa P. Malc, P. Dzierzbicki, 2012, Mutation research.

Metabolic Potential, Ecology and Presence of Associated Bacteria Is Reflected in Genomic Diversity of Mucoromycotina

P. Mieczkowski, Ewa P. Malc, A. Muszewska, 2021, Frontiers in Microbiology.

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

Isidro Cortes-Ciriano, Steven A Roberts, Eunjung Lee, 2016, PLoS genetics.

Tracking replication enzymology in vivo by genome-wide mapping of ribonucleotide incorporation

T. Kunkel, P. Mieczkowski, D. Fargo, 2014, Nature Structural &Molecular Biology.

Mutation signatures specific to DNA alkylating agents in yeast and cancers.

Cynthia J. Sakofsky, P. Mieczkowski, D. Gordenin, 2020, Nucleic acids research.

Repair of base damage within break-induced replication intermediates promotes kataegis associated with chromosome rearrangements

P. Mieczkowski, Ewa P. Malc, A. Malkova, 2019, Nucleic acids research.

Genome-wide maps of alkylation damage, repair, and mutagenesis in yeast reveal mechanisms of mutational heterogeneity

John J. Wyrick, J. Wyrick, P. Mieczkowski, 2017, Genome research.

APOBEC3B cytidine deaminase targets the non-transcribed strand of tRNA genes in yeast.

P. Mieczkowski, D. Gordenin, J. Sterling, 2017, DNA repair.

Integrated Proteogenomic Characterization of Clear Cell Renal Cell Carcinoma

Guo Ci Teo, Meghan C. Burke, Jeffrey R. Whiteaker, 2020, Cell.

Atypical UV Photoproducts Induce Non-canonical Mutation Classes Associated with Driver Mutations in Melanoma

John J. Wyrick, J. Wyrick, P. Mieczkowski, 2020, Cell reports.

Inactivation of the 20S proteasome maturase, Ump1p, leads to the instability of mtDNA in Saccharomyces cerevisiae.

Ewa P. Malc, A. Kaniak, Adrianna Skoneczna, 2009, Mutation research.

Msh1p counteracts oxidative lesion-induced instability of mtDNA and stimulates mitochondrial recombination in Saccharomyces cerevisiae.

Ewa P. Malc, A. Kaniak, P. Dzierzbicki, 2009, DNA repair.

The Shu complex prevents mutagenesis and cytotoxicity of single-strand specific alkylation lesions

Hani S. Zaher, P. Mieczkowski, Ewa P. Malc, 2021, bioRxiv.

High-Resolution Genome-Wide Analysis of Irradiated (UV and γ-Rays) Diploid Yeast Cells Reveals a High Frequency of Genomic Loss of Heterozygosity (LOH) Events

F. Dietrich, P. Mieczkowski, T. Petes, 2012, Genetics.

APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication.

P. Mieczkowski, Ewa P. Malc, Tony M Mertz, 2016, Cell reports.

Characterization of systemic genomic instability in budding yeast

K. T. Nishant, Ruth A. Watson, P. Mieczkowski, 2020, Proceedings of the National Academy of Sciences.

Cavitation Enhancing Nanodroplets Mediate Efficient DNA Fragmentation in a Bench Top Ultrasonic Water Bath

P. Mieczkowski, W. Janzen, Ewa P. Malc, 2015, PloS one.

Mitotic systemic genomic instability in yeast

Fabiana M. Duarte, K. T. Nishant, Pedro A. G. Tizei, 2017, bioRxiv.

A Case Study of Genomic Instability in an Industrial Strain of Saccharomyces cerevisiae

K. T. Nishant, Pedro A. G. Tizei, P. Mieczkowski, 2018, G3: Genes, Genomes, Genetics.

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation

Cynthia J. Sakofsky, P. Mieczkowski, D. Gordenin, 2019, PLoS biology.

Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation

Cynthia J. Sakofsky, P. Mieczkowski, D. Gordenin, 2020, PLoS Biology.

The Impact of Environmental and Endogenous Damage on Somatic Mutation Load in Human Skin Fibroblasts

Jack A. Taylor, Sara A. Grimm, P. Park, 2016, PLoS genetics.

Variant calling in low-coverage whole genome sequencing of a Native American population sample

P. Mieczkowski, Yun Li, C. Ehlers, 2014, BMC Genomics.