Yongping Yang

发表

Design and characterization of epitope-scaffold immunogens that present the motavizumab epitope from respiratory syncytial virus.

W. Schief, B. Correia, P. Kwong, 2011, Journal of molecular biology.

Structural basis of respiratory syncytial virus neutralization by motavizumab

P. Kwong, B. Graham, Man Chen, 2010, Nature Structural &Molecular Biology.

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Chaim A. Schramm, Cinque S. Soto, J. Mullikin, 2014, Nature.

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

Jamie K. Scott, H. Liao, B. Haynes, 2011, Journal of Virology.

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

Cinque S. Soto, U. Baxa, G. Chuang, 2013, Science.

Crystal structure , conformational fixation , and entry-related interactions of mature ligand-free HIV-1 Env

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016 .

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

P. Kwong, B. Graham, J. McLellan, 2011, Journal of Virology.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2011, Nature.

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Young Do Kwon, Tongqing Zhou, Peter D. Kwong, 2012, Proceedings of the National Academy of Sciences.

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

Baoshan Zhang, Wayne C Koff, Carole A Bewley, 2013, Nature Structural &Molecular Biology.

Prefusion F–specific antibodies determine the magnitude of RSV neutralizing activity in human sera

G. Chuang, M. Sastry, I. Georgiev, 2015, Science Translational Medicine.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016, Cell.

Mining the antibodyome for HIV-1–neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

Baoshan Zhang, Peter D. Kwong, John R. Mascola, 2013, Proceedings of the National Academy of Sciences.

Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2013, Immunity.

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2015, Cell.

A Neutralizing Antibody Recognizing Primarily N‐Linked Glycan Targets the Silent Face of the HIV Envelope

U. Baxa, J. Mullikin, J. Mascola, 2018, Immunity.

Antibodiesand Their Recognition by Immunotypes of a Quaternary Site of HIV-1

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2014 .

Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2011, Journal of Virology.

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

J. Mascola, T. Zhou, P. Kwong, 2010, Journal of Virology.

Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with HIV-1 surface glycoprotein.

P. Acharya, P. Kwong, Yongping Yang, 2013, Journal of medicinal chemistry.

Prefusion-Stabilized Lassa Virus Trimer Identifies Neutralizing Nanobodies and Reveals an Apex-Situated Site of Vulnerability

Mitchell Ho, J. Mascola, Baoshan Zhang, 2022, bioRxiv.

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

Cinque S. Soto, B. Haynes, J. Mascola, 2017, Cell reports.

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Alon Herschhorn, J. Sodroski, J. Mascola, 2019, Nature Communications.

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Alon Herschhorn, J. Sodroski, J. Mascola, 2019, Nature Communications.

Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

J. Mascola, G. Chuang, Y. Lai, 2020, Journal of Virology.

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

Cinque S. Soto, J. Mullikin, B. Haynes, 2016, PloS one.

Structure of an influenza group 2-neutralizing antibody targeting the hemagglutinin stem supersite.

G. Chuang, Reda Rawi, Chen-Hsiang Shen, 2022, Structure.

Interprotomer disulfide-stabilized variants of the human metapneumovirus fusion glycoprotein induce high titer-neutralizing responses

J. Mascola, G. Chuang, M. Sastry, 2021, Proceedings of the National Academy of Sciences.

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

U. Baxa, T. Zhou, P. Kwong, 2013, Science.

Interfacial cavity filling to optimize CD4-mimetic miniprotein interactions with the HIV-1 surface protein

P. Acharya, P. Kwong, Yongping Yang, 2013 .

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

Jamie K. Scott, H. Liao, B. Haynes, 2013, Journal of Virology.

Attenuation of Pulmonary Neuroendocrine Differentiation in Mice Lacking Clara Cell Secretory Protein

Cesar M. Castro, Yongping Yang, Zhongjian Zhang, 2000, Laboratory Investigation.

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Speciﬁc Antibodies That Potently Neutralize HIV-1 (cid:1) †§

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2011 .

Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine

Cinque S. Soto, U. Baxa, J. Mascola, 2016 .

Cryo-EM structures of prefusion SIV envelope trimer

J. Lifson, B. Keele, M. Roederer, 2022, Nature Structural & Molecular Biology.

Peptides from Second Extracellular Loop of C-C Chemokine Receptor Type 5 (CCR5) Inhibit Diverse Strains of HIV-1*

C. Bewley, G. Clore, P. Acharya, 2012, The Journal of Biological Chemistry.

Protection of calves by a prefusion-stabilized bovine RSV F vaccine

U. Baxa, J. Mascola, Y. Lai, 2017, npj Vaccines.

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Mario Roederer, Tongqing Zhou, Gary J. Nabel, 2011, Science.

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

B. Haynes, D. Ho, J. Mascola, 2016, Journal of Virology.

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

Baoshan Zhang, Peter D. Kwong, John R. Mascola, 2012, Nature.

Relationship between Antibody 2F5 Neutralization of HIV-1 and Hydrophobicity of Its Heavy Chain Third Complementarity-Determining Region

J. Mascola, R. Wyatt, G. Nabel, 2009, Journal of Virology.

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

C. Soto, T. Lemmin, Cinque S. Soto, 2016, Science.

Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition.

J. Mascola, G. Chuang, L. Morris, 2020, Cell reports.

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1–4

M. Beltramello, U. Baxa, J. Mascola, 2018, Proceedings of the National Academy of Sciences.

Early Low-Titer Neutralizing Antibodies Impede HIV-1 Replication and Select for Virus Escape

Alan S. Perelson, Feng Gao, Hui Li, 2012, PLoS pathogens.

Structure-Based Design of Head-Only Fusion Glycoprotein Immunogens for Respiratory Syncytial Virus

J. Mascola, M. Sastry, I. Georgiev, 2016, PloS one.

Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2010, Science.

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

E. Reinherz, G. Wagner, P. Kwong, 2011, Nature Structural &Molecular Biology.

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Cinque S. Soto, J. Mullikin, B. Haynes, 2015, Cell.

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

J. Foulke, M. Sajadi, P. Acharya, 2014, Journal of Virology.

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo

Young Do Kwon, Mario Roederer, Tongqing Zhou, 2014, Journal of Virology.

HIV-1 Infection Response Implicated in Reduced Risk for Antibody-Dependent Cellular Cytotoxicity Structural Definition of an

J. Foulke, M. Sajadi, P. Acharya, 2014 .

Structure and immune recognition of trimeric prefusion HIV-1 Env

Tongqing Zhou, Yongping Yang, Baoshan Zhang, 2014, Nature.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

J. Mascola, G. Chuang, M. Sastry, 2018, bioRxiv.

Structures of HIV-1-Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Jonathan R. McDaniel, Cinque S. Soto, U. Baxa, 2015, Nature Structural &Molecular Biology.

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains

Young Do Kwon, Tongqing Zhou, Gwo-Yu Chuang, 2013, Journal of Virology.

Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41

H. Liao, Laura L. Sutherland, B. Haynes, 2011, PloS one.

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

J. Mascola, G. Chuang, Reda Rawi, 2021, Frontiers in Immunology.

, In Vivo Infection Improves Protection against Lentiviral In Vitro Neutralizing HIV-1 Antibody Enhanced Potency of a Broadly

Kyle E. Roberts, Cinque S. Soto, B. Donald, 2014 .

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

Baoshan Zhang, Peter D. Kwong, John R. Mascola, 2010, Journal of Virology.

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

J. Mascola, Rui Chen, G. Chuang, 2018, Nature Medicine.

Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies.

Cinque S. Soto, J. Mascola, Baoshan Zhang, 2016, Structure.

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

Tongqing Zhou, Gwo-Yu Chuang, M. Gordon Joyce, 2017, Journal of Virology.

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

J. Mascola, G. Chuang, I. Georgiev, 2019, Pathogens & immunity.

Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine

Cinque S. Soto, U. Baxa, J. Mascola, 2016, Nature Structural &Molecular Biology.

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

Cinque S. Soto, U. Baxa, J. Mascola, 2015, PloS one.

Structural basis for llama nanobody recognition and neutralization of HIV-1 at the CD4-binding site.

R. Weiss, Reda Rawi, Baoshan Zhang, 2022, Structure.

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env

U. Baxa, J. Mascola, G. Chuang, 2015, Journal of Virology.

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

Cinque S. Soto, Yicheng Guo, S. Migueles, 2019, Science Immunology.

Rhesus macaque Bcl-6/Bcl-xL B cell immortalization: Discovery of HIV-1 neutralizing antibodies from lymph node.

J. Mascola, R. Koup, D. Ambrozak, 2023, Journal of immunological methods.

Transplanting Supersites of HIV-1 Vulnerability

Cinque S. Soto, D. Burton, M. Connors, 2014, PloS one.

Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.

G. Chuang, Y. Lai, Reda Rawi, 2020, Cell reports.

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

J. Mascola, D. Dimitrov, G. Chuang, 2013, Journal of Virology.

Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.

G. Chuang, K. Kirsch, Reda Rawi, 2021, Immunity.

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

J. Mascola, G. Chuang, D. Ambrozak, 2021, Vaccines.

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

J. Mascola, I. Georgiev, P. Acharya, 2013, Journal of Virology.

Bispecific antibody CAP256.J3LS targets V2-apex and CD4-binding sites with high breadth and potency

J. Mascola, Reda Rawi, Baoshan Zhang, 2023, mAbs.

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.

U. Baxa, J. Mascola, G. Chuang, 2017, Cell reports.

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

Alon Herschhorn, J. Sodroski, J. Mascola, 2019, Nature Communications.

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

U. Baxa, J. Mascola, I. Georgiev, 2018, ACS infectious diseases.

N332-Directed Broadly Neutralizing Antibodies Use Diverse Modes of HIV-1 Recognition: Inferences from Heavy-Light Chain Complementation of Function

J. Mascola, D. Burton, W. Koff, 2013, PloS one.

Vaccine elicitation and structural basis for antibody protection against alphaviruses

Chaim A. Schramm, S. Pletnev, D. Ambrozak, 2023, Cell.

Binding Mode Characterization of NBD Series CD4-Mimetic HIV-1 Entry Inhibitors by X-Ray Structure and Resistance Study

A. Debnath, P. Kwong, Yongping Yang, 2014, Antimicrobial Agents and Chemotherapy.

In Silico Improvement of Highly Protective Anti-Malarial Antibodies

Reda Rawi, Chen-Hsiang Shen, Baoshan Zhang, 2022, bioRxiv.

Structural basis for highly effective HIV-1 neutralization by CD4-mimetic miniproteins revealed by 1.5 Å cocrystal structure of gp120 and M48U1.

J. Mascola, P. Acharya, M. Louder, 2013, Structure.

Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

P. Kwong, B. Graham, Man Chen, 2010, Journal of Virology.

Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

G. Chuang, A. Lanzavecchia, Chen-Hsiang Shen, 2021, Nature Communications.

A Conserved Mechanism for Centromeric Nucleosome Recognition by Centromere Protein CENP-C

U. Baxa, A. Straight, R. Ghirlando, 2013, Science.

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

T. Kepler, H. Liao, J. Sodroski, 2011, Journal of Virology.

Crystal structure, conformational fixation, and entry-related interactions of mature ligand-free HIV-1 Env

James B. Munro, Daniel S. Terry, Cinque S. Soto, 2015, Nature Structural &Molecular Biology.

Enhancing Anti-SARS-CoV-2 Neutralizing Immunity by Genetic Delivery of Enveloped Virus-like Particles Displaying SARS-CoV-2 Spikes

J. Mascola, R. Koup, Reda Rawi, 2023, Vaccines.

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

A. Debnath, Judith M. LaLonde, P. Kwong, 2014, PloS one.

Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2011, Journal of Virology.

Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases

J. Mascola, R. Koup, Reda Rawi, 2023, iScience.

Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04

J. Mascola, G. Nabel, T. Zhou, 2012, Journal of Virology.

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

J. Mullikin, B. Haynes, J. Mascola, 2011, Science.

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo

Kyle E. Roberts, Cinque S. Soto, B. Donald, 2014, Journal of Virology.

Cleavage-intermediate Lassa virus trimer elicits neutralizing responses, identifies neutralizing nanobodies, and reveals an apex-situated site-of-vulnerability

Chaim A. Schramm, J. Mascola, Chen-Hsiang Shen, 2024, Nature communications.

Multidonor analysis reveals structural elements, genetic determinants, and maturation pathway for HIV-1 neutralization by VRC01-class antibodies.

Chaim A. Schramm, J. Mullikin, B. Haynes, 2013, Immunity.