A. Kornev

发表

The cAMP binding domain: an ancient signaling module.

Susan S. Taylor, D. Goodsell, L. T. Ten Eyck, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Tuning the “violin” of protein kinases: The role of dynamics‐based allostery

Susan S. Taylor, A. Kornev, Lalima G. Ahuja, 2019, IUBMB life.

Allostery through the computational microscope: cAMP activation of a canonical signaling domain

Rommie E. Amaro, Susan S. Taylor, A. Kornev, 2015, Nature Communications.

Protein kinases: evolution of dynamic regulatory proteins.

Susan S. Taylor, A. Kornev, 2011, Trends in biochemical sciences.

Surface comparison of active and inactive protein kinases identifies a conserved activation mechanism

Susan S. Taylor, L. T. Ten Eyck, N. Haste, 2006, Proceedings of the National Academy of Sciences.

Defining the Conserved Internal Architecture of a Protein Kinase

Susan S. Taylor, S. Taylor, A. Kornev, 2010, Biochimica et biophysica acta.

A helix scaffold for the assembly of active protein kinases

Lynn F. Ten Eyck, Susan S. Taylor, Alexandr P. Kornev, 2008, Proceedings of the National Academy of Sciences.

Assembly of allosteric macromolecular switches: lessons from PKA

Ping Zhang, Susan S. Taylor, Alexandr P. Kornev, 2012, Nature Reviews Molecular Cell Biology.

Dynamic architecture of a protein kinase

Christopher L. McClendon, Susan S. Taylor, M. Gilson, 2014, Proceedings of the National Academy of Sciences.

A dynamic hydrophobic core orchestrates allostery in protein kinases

Christopher L. McClendon, Susan S. Taylor, A. Kornev, 2017, Science Advances.

Dynamics connect substrate recognition to catalysis in protein kinase A.

Tao Yu, Gianluigi Veglia, Susan S. Taylor, 2010, Nature chemical biology.

Disordered Protein Kinase Regions in Regulation of Kinase Domain Cores.

Susan S. Taylor, A. Reményi, A. Kornev, 2019, Trends in biochemical sciences.

Kinase Regulation by Hydrophobic Spine Assembly in Cancer

Susan S. Taylor, N. Kannan, A. Kornev, 2014, Molecular and Cellular Biology.

Dynamic allostery-based molecular workings of kinase:peptide complexes

Susan S. Taylor, A. Kornev, Lalima G. Ahuja, 2019, Proceedings of the National Academy of Sciences.

The dynamic switch mechanism that leads to activation of LRRK2 is embedded in the DFGψ motif in the kinase domain

Susan S. Taylor, Mark Ellisman, A. Kornev, 2019, Proceedings of the National Academy of Sciences.

Pseudokinases: functional insights gleaned from structure.

Susan S. Taylor, A. Kornev, 2009, Structure.

A Catalytically Disabled Double Mutant of Src Tyrosine Kinase Can Be Stabilized into an Active-Like Conformation.

Susan S. Taylor, B. Roux, Yilin Meng, 2018, Journal of molecular biology.

PHYSICAL ASPECTS OF PENETRANT TESTING FOR LIQUID PHASE DEVELOPERS

A. Kornev, P. Prokhorenko, I. Stoicheva, 1997 .

Finite geometries and related loops and quasigroups

A. Kornev, D. Rasskazova, P. Kochloukov, 2018 .

Electrostatic Interactions as Mediators in the Allosteric Activation of Protein Kinase A RIα.

Rommie E. Amaro, Susan S. Taylor, A. Kornev, 2017, Biochemistry.

Dynamics-Driven Allostery in Protein Kinases.

Susan S. Taylor, A. Kornev, 2015, Trends in biochemical sciences.

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Susan S. Taylor, A. Kornev, Jiancheng Hu, 2013, Cell.

Intramolecular C 2 Domain-Mediated Autoinhibition of Protein Kinase C b II Graphical Abstract Highlights

Susan S. Taylor, A. Newton, A. Kornev, 2015 .

Mutations in protein kinase Cγ promote spinocerebellar ataxia type 14 by impairing kinase autoinhibition

Susan S. Taylor, A. Newton, N. Kannan, 2022, Science Signaling.

Evolution of a dynamic molecular switch

Susan S. Taylor, A. Kornev, Hiruy S. Meharena, 2019, IUBMB life.

On globally stable dynamic processes

A. Kornev, 2002 .

Calculation of centralities in protein kinase A

Susan S. Taylor, A. Kornev, P. Aoto, 2022, bioRxiv.

PKA RIα homodimer structure reveals an intermolecular interface with implications for cooperative cAMP binding and Carney complex disease.

Susan S. Taylor, D. Blumenthal, Jian Wu, 2014, Structure.

mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif

Susan S. Taylor, A. Newton, N. Kannan, 2021, Science Signaling.

Evolution of the eukaryotic protein kinases as dynamic molecular switches

Susan S. Taylor, A. Kornev, J. Steichen, 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.

Comparative surface geometry of the protein kinase family

Susan S. Taylor, L. T. Ten Eyck, N. Kannan, 2009, Protein science : a publication of the Protein Society.

Kinases and Pseudokinases: Lessons from RAF

Susan S. Taylor, A. Kornev, Lalima G. Ahuja, 2014, Molecular and Cellular Biology.

Conserved spatial patterns across the protein kinase family.

Susan S. Taylor, L. T. Ten Eyck, A. Kornev, 2008, Biochimica et biophysica acta.

PKA: lessons learned after twenty years.

Susan S. Taylor, A. Kornev, J. Steichen, 2013, Biochimica et biophysica acta.

Deciphering the Structural Basis of Eukaryotic Protein Kinase Regulation

Susan S. Taylor, Alexandr P. Kornev, Krishnadev Oruganty, 2013, PLoS biology.

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

Susan S. Taylor, A. Kornev, Jiancheng Hu, 2011, Proceedings of the National Academy of Sciences.

Integration of signaling in the kinome: Architecture and regulation of the αC Helix.

Susan S. Taylor, N. Kannan, A. Kornev, 2015, Biochimica et biophysica acta.

, Lalima RAF Kinases and Pseudokinases : Lessons from

Susan S. Taylor, A. Kornev, Lalima G. Ahuja, 2014 .

From structure to the dynamic regulation of a molecular switch: A journey over 3 decades

Susan S. Taylor, L. T. Ten Eyck, Jian Wu, 2021, The Journal of biological chemistry.

PKA and the Structural Kinome

Susan S. Taylor, A. Kornev, 2017 .

Mutation of a kinase allosteric node uncouples dynamics linked to phosphotransfer

Christopher L. McClendon, Susan S. Taylor, A. Kornev, 2017, Proceedings of the National Academy of Sciences.

Discovery of Allostery in PKA Signaling

Susan S. Taylor, Jian Wu, A. Kornev, 2015, Biophysical Reviews.

Pseudokinases from a structural perspective.

Susan S. Taylor, A. Kornev, Jiancheng Hu, 2013, Biochemical Society transactions.

Structure and Allostery of the PKA RIIβ Tetrameric Holoenzyme

Susan S. Taylor, Michael S. Deal, A. Kornev, 2012, Science.

Realizing the allosteric potential of the tetrameric protein kinase A RIα holoenzyme.

Susan S. Taylor, Jian Wu, Jie Yang, 2011, Structure.

A chimeric mechanism for polyvalent trans‐phosphorylation of PKA by PDK1

Susan S. Taylor, N. Kannan, A. Kornev, 2009, Protein science : a publication of the Protein Society.

Divalent metal ions control activity and inhibition of protein kinases.

A. Kornev, B. Zimmermann, F. Herberg, 2017, Metallomics : integrated biometal science.

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII.

Susan S. Taylor, A. Newton, A. Kornev, 2015, Cell reports.

A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold.

Virgil L. Woods, Susan S. Taylor, Michael S. Deal, 2012, Journal of molecular biology.

A Generalized Allosteric Mechanism for cis-Regulated Cyclic Nucleotide Binding Domains

Lynn F. Ten Eyck, Susan S. Taylor, Alexandr P. Kornev, 2008, PLoS Comput. Biol..

Protein Kinase Cγ Mutations Drive Spinocerebellar Ataxia Type 14 by Impairing Autoinhibition

Susan S. Taylor, A. Newton, N. Kannan, 2021, bioRxiv.

Localization and quaternary structure of the PKA RIβ holoenzyme

Susan S. Taylor, Michael S. Deal, D. Blumenthal, 2012, Proceedings of the National Academy of Sciences.

Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase

Susan S. Taylor, P. Insel, A. Kornev, 2012, Proceedings of the National Academy of Sciences.

An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes.

Susan S. Taylor, Jian Wu, A. Kornev, 2015, Structure.

Self-organization, entropy and allostery.

A. Kornev, 2018, Biochemical Society transactions.

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

Susan S. Taylor, A. Newton, G. Manning, 2023, bioRxiv.

Hypothesis: Unifying model of domain architecture for conventional and novel protein kinase C isozymes

Susan S. Taylor, A. Newton, A. Kornev, 2020, IUBMB life.

Crystal structure of cGMP-dependent protein kinase reveals novel site of interchain communication

Virgil L. Woods, Susan S. Taylor, B. Sankaran, 2011, Structure.

Dissecting the cAMP‐inducible allosteric switch in protein kinase A RIα

Susan S. Taylor, A. Kornev, T. Sjoberg, 2010, Protein science : a publication of the Protein Society.

Allostery Explained Through Synchronized Oscillators and Fractal Networks

A. Kornev, 2020 .

Yet another “active” pseudokinase, Erb3

Susan S. Taylor, A. Kornev, 2010, Proceedings of the National Academy of Sciences of the United States of America.

Single-residue mutation in protein kinase C toggles between cancer and neurodegeneration

Susan S. Taylor, A. Newton, G. Manning, 2023, The Biochemical journal.

The evolution of protein phosphorylation

Susan S. Taylor, T. Pawson, T. Hunter, 2016 .

Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure

Jacqueline Palace, A. Kornev, R. Herbst, 2019, Human mutation.

A conserved Glu-Arg salt bridge connects coevolved motifs that define the eukaryotic protein kinase fold.

Virgil L. Woods, Susan S. Taylor, Michael S. Deal, 2012, Journal of molecular biology.

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

Susan S. Taylor, A. Kornev, Jiancheng Hu, 2011, Proceedings of the National Academy of Sciences.

Dynamics connect substrate recognition to catalysis in protein kinase A.

Susan S. Taylor, A. Kornev, L. Masterson, 2010, Nature chemical biology.

Protein Kinase Structure and Dynamics: Role of the αC-β4 Loop

Jian Wu, A. Kornev, G. Veglia, 2023, bioRxiv.

Dissecting the cAMP‐inducible allosteric switch in protein kinase A RIα

Susan S. Taylor, A. Kornev, T. Sjoberg, 2010, Protein science : a publication of the Protein Society.

Gauging dynamics-driven allostery using a new computational tool: A CAP case study.

A. Kornev, Jui-Hung Weng, Susan S. Taylor, 2023, Journal of molecular biology.

Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure

Jacqueline Palace, A. Kornev, R. Herbst, 2019, Human Mutation.

Human Mutation

Jacqueline A Palace, A. Kornev, R. Herbst, 2019 .

Divalent metal ions control activity and inhibition of protein kinases.

A. Kornev, B. Zimmermann, F. Herberg, 2017, Metallomics : integrated biometal science.