I. Sadowski

发表

Factors controlling chromatin organization and nucleosome positioning for establishment and maintenance of HIV latency.

I. Sadowski, Pedro Lourenco, T. Malcolm, 2008, Current HIV research.

Identification of the mismatch repair genes PMS2 and MLH1 as p53 target genes by using serial analysis of binding elements.

Ivan Sadowski, I. Sadowski, Jiguo Chen, 2005, Proceedings of the National Academy of Sciences of the United States of America.

GAL4-VP16 is an unusually potent transcriptional activator

Jun Ma, Ivan Sadowski, Mark Ptashne, 1988, Nature.

Multiple Signals Regulate GALTranscription in Yeast

I. Sadowski, J. Rohde, Jennifer Trinh, 2000, Molecular and Cellular Biology.

Two Regulators of Ste12p Inhibit Pheromone-Responsive Transcription by Separate Mechanisms

Ivan Sadowski, I. Sadowski, C. Astell, 2000, Molecular and Cellular Biology.

Diversity of small molecule HIV‐1 latency reversing agents identified in low‐ and high‐throughput small molecule screens

I. Sadowski, Pargol Hashemi, 2019, Medicinal research reviews.

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

T. Pawson, I. Sadowski, J. Stone, 1986, Molecular and Cellular Biology.

A conserved domain regulates interactions of the v-fps protein-tyrosine kinase with the host cell.

T. Pawson, G. Martin, I. Sadowski, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Mitogen-responsive expression of RhoB is regulated by RNA stability

I. Sadowski, T. Malcolm, E. Ettehadieh, 2003, Oncogene.

Regulation of Skn7-dependent, oxidative stress-induced genes by the RNA polymerase II-CTD phosphatase, Fcp1, and Mediator kinase subunit, Cdk8, in yeast

J. Benschop, F. Holstege, N. Krogan, 2019, The Journal of Biological Chemistry.

GAL4 is regulated by a glucose‐responsive functional domain.

I. Sadowski, G. Stone, Geoffrey W. Stone, 1993, The EMBO journal.

Catalytic and non-catalytic domains of the Fujinami sarcoma virus P130gag-fps protein-tyrosine kinase distinguished by the expression of v-fps polypeptides in Escherichia coli.

T. Pawson, I. Sadowski, 1987, Oncogene.

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function

M. Moran, T. Pawson, I. Sadowski, 1989, Molecular and cellular biology.

A Multipronged Screening Approach Targeting Inhibition of ETV6 PNT Domain Polymerization

R. Sessions, L. McIntosh, I. Sadowski, 2020, bioRxiv.

Menadione inhibition of benzo(a)pyrene metabolism in whole cells, microsomes and reconstituted systems.

I. Sadowski, L. Israels, J. Wright, 1986, The International journal of biochemistry.

A permeabilized cell system for studying regulation of aryl hydrocarbon hydroxylase: NADPH as rate limiting factor in benzo(a)pyrene metabolism.

I. Sadowski, L. Israels, J. Wright, 1985, The International journal of biochemistry.

Specific interaction of TFII‐I with an upstream element on the HIV‐1 LTR regulates induction of latent provirus

I. Sadowski, T. Malcolm, J. Kam, 2008, FEBS letters.

TOR signaling modulates Cdk8-dependent GAL gene expression in Saccharomyces cerevisiae

I. Sadowski, J. Rohde, N. Hawe, 2020, bioRxiv.

Identification of protein interaction antagonists using the repressed transactivator two-hybrid system.

K. Lund, M. Hirst, I. Sadowski, 2007, BioTechniques.

A genetic system for studying the activity of a proteolytic enzyme.

I. Sadowski, B. Didomenico, B. Dasmahapatra, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Dominant marker vectors for selecting yeast mating products

I. Sadowski, Pedro Lourenco, Jennifer Parent, 2008, Yeast.

Disintegrator vectors for single‐copy yeast chromosomal integration

I. Sadowski, Jennifer Parent, Ting-Cheng Su, 2007, Yeast.

Uses for GAL4 expression in mammalian cells.

I. Sadowski, 1995, Genetic engineering.

Organization and expression of the Cyr61 gene in normal human fibroblasts.

I. Sadowski, T. Malcolm, E. Leng, 2002, Journal of biomedical science.

HIV Provirus Stably Reproduces Parental Latent and Induced Transcription Phenotypes Regardless of the Chromosomal Integration Site

I. Sadowski, F. Hashemi, Pargol Hashemi, 2016, Journal of Virology.

Cytochrome b 5 is a major reductant in vivo of human indoleamine 2,3‐dioxygenase expressed in yeast

R. MacGillivray, M. Page, I. Sadowski, 2006, FEBS letters.

Inhibition of the TRIM24 bromodomain reactivates latent HIV-1

I. Sadowski, Z. Brumme, Riley Horvath, 2022, bioRxiv.

Mutational analysis of a phosphotransfer motif essential for v-fps tyrosine kinase activity.

M. Moran, T. Pawson, I. Sadowski, 1988, Oncogene.

Organization and Expression of the Cyr61 Gene in Normal Human Fibroblasts

I. Sadowski, T. Malcolm, E. Leng, 2002, Journal of Biomedical Science.

STRUCTURE-FUNCTION RELATIONSHIPS IN CELLULAR AND VIRAL fps/fes

M. Moran, T. Pawson, A. Brooks-Wilson, 1988 .

Structure-function relationships in cellular and viral fps/fes cytoplasmic protein-tyrosine kinases.

M. Moran, T. Pawson, A. Brooks-Wilson, 1988, Advances in experimental medicine and biology.

RK bacterial test for independently measuring chemical toxicity and mutagenicity: short-term forward selection assay.

I. Sadowski, C. Hayes, S. Hayes, 1984, Mutation research.

Whole Genome Duplication and Enrichment of Metal Cation Transporters Revealed by De Novo Genome Sequencing of Extremely Halotolerant Black Yeast Hortaea werneckii

I. Birol, Steven J. M. Jones, C. Nislow, 2013, PloS one.

A vector for expressing GAL4(1-147) fusions in mammalian cells.

M. Ptashne, I. Sadowski, Ivan Sadowski, 1989, Nucleic acids research.

Compounds producing an effective combinatorial regimen for disruption of HIV‐1 latency

I. Sadowski, T. Pfeifer, Pargol Hashemi, 2017, EMBO molecular medicine.

A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps

T Pawson, J C Stone, T. Pawson, 1986, Molecular and cellular biology.

Isolation and identification of L-dopa decarboxylase as a protein that binds to and enhances transcriptional activity of the androgen receptor using the repressed transactivator yeast two-hybrid system.

M. Hirst, I. Sadowski, P. Rennie, 2003, The Biochemical journal.

GAL4 is phosphorylated as a consequence of transcriptional activation.

M. Ptashne, I. Sadowski, K. Wood, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Srb10/Cdk8 regulates yeast filamentous growth by phosphorylating the transcription factor Ste12

K. Lund, I. Sadowski, C. Nelson, 2003, Nature.

Cdk8 Regulates Stability of the Transcription Factor Phd1 To Control Pseudohyphal Differentiation of Saccharomyces cerevisiae

Ivan Sadowski, Ting-Cheng Su, Sheetal Raithatha, 2011, Molecular and Cellular Biology.

Inactivation of a yeast transactivator by the fused HIV-1 proteinase: a simple assay for inhibitors of the viral enzyme activity.

I. Sadowski, M. Murray, W. Hung, 1993, Gene.

TFII-I Regulates Induction of Chromosomally Integrated Human Immunodeficiency Virus Type 1 Long Terminal Repeat in Cooperation with USF

R. Roeder, I. Sadowski, T. Malcolm, 2005, Journal of Virology.

GAL4 is regulated by the RNA polymerase II holoenzyme-associated cyclin-dependent protein kinase SRB10/CDK8.

J. Greenblatt, M. Hirst, M. Kobor, 1999, Molecular cell.

A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II.

Kevin Struhl, Min Han, Michael Carey, 2004, Molecular cell.

Purification of RBF-2, a Transcription Factor with Specificity for the Most Conserved cis-Element of Naturally Occurring HIV-1 LTRs

M. Hirst, I. Sadowski, M. O’Shaughnessy, 1999, Journal of Biomedical Science.

Purification of RBF-2, a transcription factor with specificity for the most conserved cis-element of naturally occurring HIV-1 LTRs.

M. Hirst, I. Sadowski, M. O’Shaughnessy, 1999, Journal of biomedical science.

An Upstream YY1 Binding Site on the HIV-1 LTR Contributes to Latent Infection

I. Sadowski, Sheetal Raithatha, K. Barreto, 2013, PloS one.

PhosphoGRID: a database of experimentally verified in vivo protein phosphorylation sites from the budding yeast Saccharomyces cerevisiae

Mike Tyers, Chris Stark, Ashton Breitkreutz, 2010, Database J. Biol. Databases Curation.

Direct non-productive HIV-1 infection in a T-cell line is driven by cellular activation state and NFκB

I. Sadowski, V. Simon, C. Brumme, 2014, Retrovirology.

The PhosphoGRID Saccharomyces cerevisiae protein phosphorylation site database: version 2.0 update

Kara Dolinski, Mike Tyers, Chris Stark, 2013, Database J. Biol. Databases Curation.

Induction of chromosomally integrated HIV-1 LTR requires RBF-2 (USF/TFII-I) and RAS/MAPK signaling

I. Sadowski, T. Malcolm, Jiguo Chen, 2007, Virus Genes.

Identification and functional analysis of a second RBF-2 binding site within the HIV-1 promoter.

I. Sadowski, T. Malcolm, V. Simon, 2011, Virology.

TFII-I and USF (RBF-2) regulate Ras/MAPK-responsive HIV-1 transcription in T cells.

I. Sadowski, David Mitchell, 2005, European journal of cancer.

Strategies to eradicate HIV from infected patients: elimination of latent provirus reservoirs

I. Sadowski, F. Hashemi, 2019, Cellular and Molecular Life Sciences.

A Doubly Fluorescent HIV-1 Reporter Shows that the Majority of Integrated HIV-1 Is Latent Shortly after Infection

I. Sadowski, V. Simon, Marcel Ooms, 2013, Journal of Virology.

TRIM24 controls induction of latent HIV-1 by stimulating transcriptional elongation

I. Sadowski, T. Malcolm, M. Dahabieh, 2021, bioRxiv.

Phosphorylation of Ga14p at a single C-terminal residue is necessary for galactose-inducible transcription

I. Sadowski, R. Dhanawansa, C. Costa, 1996, Molecular and cellular biology.

A two-hybrid system for transactivator bait proteins

M. Hirst, L. Penn, I. Sadowski, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Naturally Occurring Human Immunodeficiency Virus Type 1 Long Terminal Repeats Have a Frequently Observed Duplication That Binds RBF-2 and Represses Transcription

M. Hirst, I. Sadowski, B. Bell, 1998, Journal of Virology.

Cdk8 directly regulates glycolysis via phosphorylation of Gcr2

E. O'Duibhir, Mariël Brok, P. Lijnzaad, 2021, bioRxiv.

GAL4 fusion vectors for expression in yeast or mammalian cells.

I. Sadowski, B. Bell, P. Broad, 1992, Gene.

Protein Domain Fusion

I. Sadowski, 2001 .

Wild type GAL4 binds cooperatively to the GAL1-10 UASG in vitro.

I. Sadowski, T. Martins, T. Kang, 1993, The Journal of biological chemistry.

Characterization of the basal and pheromone-stimulated phosphorylation states of Ste12p.

A. Breitkreutz, I. Sadowski, K. Olson, 1997, European journal of biochemistry.

Organizational constraints on Ste12 cis‐elements for a pheromone response in Saccharomyces cerevisiae

I. Sadowski, E. Tamarkina, Ting-Cheng Su, 2010, The FEBS journal.

The Suv39H1 methyltransferase inhibitor chaetocin causes induction of integrated HIV‐1 without producing a T cell response

I. Sadowski, Pauline Johnson, A. Saunders, 2011, FEBS letters.

Mutations that increase the activity of a transcriptional activator in yeast and mammalian cells.

M. Ptashne, I. Sadowski, G. Gill, 1990, Proceedings of the National Academy of Sciences of the United States of America.

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

I. Sadowski, Z. Brumme, Riley M. Horvath, 2023, bioRxiv.

Human immunodeficiency virus type 1 long terminal repeat variants from 42 patients representing all stages of infection display a wide range of sequence polymorphism and transcription activity

J. Montaner, I. Sadowski, A. Merzouki, 1996, Journal of virology.

Upstream Stimulatory Factors Regulate HIV-1 Latency and Are Required for Robust T Cell Activation

I. Sadowski, Riley M Horvath, 2023, bioRxiv.

A Unified Nomenclature for Protein Subunits of Mediator Complexes Conserved from Fungi to Humans: Med6/pmc5/arc/ Drip33/trap32, Med7/arc/drip/trap34/crsp33, Linking Transcriptional Regulators to Rna Polymerase Ii Arc/crsp/drip150/trap170, Soh1/trap18 (note That Soh1 Has Not Been yet Identified in Pu

F. Holstege, S. W. Emmons, A. Hinnebusch, 2022 .

Ras-responsiveness of the HIV-1 LTR requires RBF-1 and RBF-2 binding sites.

I. Sadowski, B. Bell, 1996, Oncogene.

Mapping a protein-binding site on straightened DNA by atomic force microscopy.

B. Trask, G. van den Engh, D. Nickerson, 1998, Analytical biochemistry.

Small molecule inhibitors of transcriptional cyclin-dependent kinases impose HIV-1 latency, presenting “block and lock” treatment strategies

I. Sadowski, Z. Brumme, Riley M Horvath, 2023, bioRxiv.