D. Beach

发表

Regulation of NF-κB by Cyclin-Dependent Kinases Associated with the p300 Coactivator

G. Nabel, N. Perkins, L. Felzien, 1997, Science.

Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.

P. Friedman, D. Beach, C. Prives, 1990, Proceedings of the National Academy of Sciences of the United States of America.

p21 is a universal inhibitor of cyclin kinases

David Beach, Gregory J. Hannon, Ryuji Kobayashi, 1993, Nature.

Inhibition of ras-induced proliferation and cellular transformation by p16INK4

R. DePinho, D. Bar-Sagi, D. Beach, 1995, Science.

Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a

S. Lowe, M. Serrano, D. Beach, 1997, Cell.

An RNA-directed nuclease mediates post-transcriptional gene silencing in Drosophila cells

S. Hammond, G. Hannon, E. Bernstein, 2000, Nature.

Distinct nuclear and spindle pole body populations of cyclin–cdc2 in fission yeast

D. Beach, B. Ducommun, C. Alfa, 1990, Nature.

Fission yeast cyclin: subcellular localisation and cell cycle regulation

D. Beach, R. Booher, C. Alfa, 1989, Journal of Cell Science.

Identification of seven new cut genes involved in Schizosaccharomyces pombe mitosis.

M. Yanagida, D. Beach, Y. Nakaseko, 1993, Journal of cell science.

Chromosomal mapping of the human genes CKS1 to 8q21 and CKS2 to 9q22.

D. Demetrick, D. Beach, H. Zhang, 1996, Cytogenetics and cell genetics.

Mutations and altered expression of p16INK4 in human cancer.

A. Okamoto, D. Demetrick, M. Serrano, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Deletion of the p16 and p15 genes in human bladder tumors.

G. Hannon, C. Cordon-Cardo, V. Reuter, 1995, Journal of the National Cancer Institute.

Proliferating cell nuclear antigen and p21 are components of multiple cell cycle kinase complexes.

D. Beach, Y. Xiong, D. Beach, 1993, Molecular biology of the cell.

A specific inhibitor of the ran1+ protein kinase regulates entry into meiosis in Schizosaccharomyces pombe

D. Beach, M. McLeod, M. Mcleod, 1988, Nature.

RAN1+ controls the transition from mitotic division to meiosis in fission yeast

L. Rodgers, D. Beach, J. Gould, 2004, Current Genetics.

Subcellular distribution of p21 and PCNA in normal and repair-deficient cells following DNA damage

G. Hannon, B. Stillman, D. Beach, 1996, Current Biology.

p21-containing cyclin kinases exist in both active and inactive states.

G. Hannon, D. Beach, D. Beach, 1994, Genes & development.

Differential effects by the p21 CDK inhibitor on PCNA-dependent DNA replication and repair

G. Hannon, B. Stillman, D. Beach, 1994, Nature.

Interaction between cdc13+ and cdc2+ in the control of mitosis in fission yeast; dissociation of the G1 and G2 roles of the cdc2+ protein kinase.

D. Beach, R. Booher, 1987, The EMBO journal.

Physical Interaction of Mammalian CDC37 with CDK4*

R. Kobayashi, D. Beach, D. Beach, 1996, The Journal of Biological Chemistry.

KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.

G. Hannon, D. Beach, D. Beach, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Ageing as developmental decay: insights from p16(INK4a.).

D. Beach, J. Gil, Nadine Martin, 2014, Trends in molecular medicine.

p16INK4A and p19ARF act in overlapping pathways in cellular immortalization

D. Beach, A. Carnero, J. Hudson, 2000, Nature Cell Biology.

Activation of M-phase-specific histone H1 kinase by modification of the phosphorylation of its p34cdc2 and cyclin components.

D. Beach, L. Meijer, P. Pondaven, 1990, Genes & development.

Screening for antimitotic compounds using the cdc25 tyrosine phosphatase, an activator of the mitosis-inducing p34cdc2/cyclin Bcdc13 protein kinase.

L. Meijer, D. Beach, D. Beach, 1992, Anticancer research.

Multiple phosphorylated forms of the product of the fission yeast cell division cycle gene cdc2+

J. Potashkin, D. Beach, 1988, Current Genetics.

Cell cycle regulation of histone H1 kinase activity associated with the adenoviral protein E1A.

B. Franza, D. Beach, A. Giordano, 1991, Science.

Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.

D. Demetrick, D. Beach, H. Zhang, 1994, Cytogenetics and cell genetics.

cdc2 and the regulation of mitosis: six interacting mcs genes.

D. Beach, R. Booher, P. Young, 1989, Genetics.

Isolation of chromosomal origins of replication in yeast

D. Beach, S. Shall, M. Piper, 1980, Nature.

p21 is a component of active cell cycle kinases.

G. Hannon, D. Beach, D. Casso, 1994, Cold Spring Harbor symposia on quantitative biology.

Mutations associated with familial melanoma impair p16INK4 function

H. Varmus, R. Sikorski, G. Hannon, 1995, Nature Genetics.

cdt1 is an essential target of the Cdc10/Sct1 transcription factor: requirement for DNA replication and inhibition of mitosis.

D. Beach, D. Beach, J. Hofmann, 1994, The EMBO journal.

Fission yeast enters the stationary phase G0 state from either mitotic G1 or G2

L. Rodgers, D. Beach, G. Costello, 1986, Current Genetics.

The fission yeast cell cycle control gene cdc2: isolation of a sequence suc1 that suppresses cdc2 mutant function

J. Hayles, P. Nurse, D. Beach, 1986, Molecular and General Genetics MGG.

Involvement of a type 1 protein phosphatase encoded by bws1 + in fission yeast mitotic control

D. Beach, R. Booher, 1989, Cell.

The fission yeast cell cycle control gene cdc2: structure of the cdc2 region

J. Hayles, P. Nurse, D. Beach, 1985, Molecular and General Genetics MGG.

Isolation of .the Rb-r.elated p 130 through its mteraeuon wlUl CDK2 and eyelins

G. Hannon, D. Demetrick, D. Beach, 1993 .

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.

D. Beach, Y. Xiong, D. Beach, 1993, Genes & development.

Site-specific mutagenesis of cdc2+, a cell cycle control gene of the fission yeast Schizosaccharomyces pombe

D. Beach, R. Booher, 1986, Molecular and cellular biology.

Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate

D. Morrison, H. Piwnica-Worms, D. Beach, 1988, Nature.

Primary cilium-dependent and -independent Hedgehog signaling inhibits p16(INK4A).

D. Beach, M. Stampfer, J. Garbe, 2010, Molecular cell.

Absence of p21WAF1 cooperates with c-myc in bypassing Ras-induced senescence and enhances oncogenic cooperation

D. Beach, A. Carnero, 2004, Oncogene.

p16(Ink4a) in melanocyte senescence and differentiation.

L. Chin, R. DePinho, D. Beach, 2002, Journal of the National Cancer Institute.

Loss-of-function genetics in mammalian cells: the p53 tumor suppressor model.

G. Hannon, D. Beach, J. Hudson, 2000, Nucleic acids research.

Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3).

G. Hannon, D. Demetrick, D. Beach, 1995, Cytogenetics and cell genetics.

Cyclin G is a transcriptional target of the p53 tumor suppressor protein.

D. Beach, K. Okamoto, David Beach, 1994, The EMBO journal.

Human p53 inhibits growth in Schizosaccharomyces pombe

D. Beach, J. Bischoff, D. Casso, 1992, Molecular and cellular biology.

MaRX: An Approach to Genetics in Mammalian Cells

G. Hannon, D. Beach, A. Carnero, 1999, Science.

Association of Rat pl5INK4Blpl6INK4 Deletions with Monosomy 5 in Kidney Epithelial Cell Lines but not Primary Renal Tumors1

D. Beach, C. Walker, Manuel, 2006 .

Association of rat p15INK4B/p16INK4 deletions with monosomy 5 in kidney epithelial cell lines but not primary renal tumors.

M. Serrano, D. Beach, C. Walker, 1995, Cancer research.

Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.

D. Ward, D. Beach, Y. Xiong, 1992, Genomics.

Homology between the ran1+ gene of fission yeast and protein kinases.

D. Beach, M. McLeod, M. Mcleod, 1986, The EMBO journal.

Cloning and characterization of murine p16(INK4a) and p15(INK4b) genes

G. Hannon, M. Serrano, D. Beach, 1995 .

Interaction between ran1+ protein kinase and cAMP dependent protein kinase as negative regulators of fission yeast meiosis.

D. Beach, G. Seydoux, M. McLeod, 1991, The EMBO journal.

p 53-Dependent and independent expression of p 21 during cell growth , differentiation , and DNA damage

K. Kinzler, B. Vogelstein, T. Jacks, 2007 .

Isolation of newly-initiated DNA from the early S phase of the synchronous eukaryote, Physarum polycephalum.

D. Beach, S. Shall, M. Piper, 1980, Experimental cell research.

ISOLATION OF EUKARYOTE DNA REPLICATION ORIGINS

D. Beach, S. Shall, M. Piper, 1980 .

A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2

M. Roussel, D. Beach, C. Sherr, 1999, Oncogene.

Suppression of growth in vitro and tumorigenicity in vivo of human carcinoma cell lines by transfected p16INK4

A. Okamoto, D. Demetrick, M. Serrano, 1996, Molecular carcinogenesis.

Myc confers androgen-independent prostate cancer cell growth.

D. Beach, D. Bernard, J. Gil, 2003, The Journal of clinical investigation.

Vectors for the construction of gene banks and the integration of cloned genes in Schizosaccharomyces pombe and Saccharomyces cerevisiae.

P. Nurse, W. Heyer, D. Beach, 1986, Plasmid.

The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA

G. Hannon, B. Stillman, D. Beach, 1994, Nature.

Twist is a potential oncogene that inhibits apoptosis.

L. Kedes, G. Hannon, A. D. Dei Tos, 1999, Genes & development.

pathways in cellular immortalization

D. Beach, A. Carnero, J. Hudson, 2000 .

Glycolytic enzymes can modulate cellular life span.

David Beach, Jing Wang, G. Peters, 2005, Cancer research.

Senescence-inducing stress promotes proteolysis of phosphoglycerate mutase via ubiquitin ligase Mdm2

David Beach, Koji Okamoto, Masayuki Yokode, 2014, The Journal of cell biology.

JCB_201306149 1..17

G. Peters, D. Beach, H. Nakagama, 2014 .

A high glycolytic flux supports the proliferative potential of murine embryonic stem cells.

D. Beach, D. Bernard, H. Kondoh, 2006, Antioxidants & redox signaling.

Glycolysis and cellular immortalization

G. Peters, D. Beach, H. Kondoh, 2005 .

A Proinflammatory Cytokine Inhibits P53 Tumor Suppressor Activity

G. Hannon, R. Maestro, D. Beach, 1999, The Journal of experimental medicine.

Targeting CDK4 and CDK6: From Discovery to Therapy.

G. Shapiro, D. Beach, C. Sherr, 2016, Cancer discovery.

Repression of cyclin D1: a novel function of MYC.

K. Alitalo, D. Beach, Y. Xiong, 1994, Molecular and cellular biology.

Tumour biology: Senescence in premalignant tumours

M. Barbacid, A. Efeyan, C. Guerra, 2005, Nature.

A p16INK4a-insensitive CDK4 mutant targeted by cytolytic T lymphocytes in a human melanoma

M. Serrano, D. Beach, T. Hankeln, 1995, Science.

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

G. Hannon, D. Beach, M. Serrano, 1993, Nature.

High-frequency transformation of the fission yeast Schizosaccharomyces pombe

P. Nurse, D. Beach, 1981, Nature.

p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest.

G. Hannon, D. Beach, 1994, Nature.

cdc2 protein kinase is complexed with both cyclin A and B: Evidence for proteolytic inactivation of MPF

David Beach, Giulio Draetta, Joan Ruderman, 1989, Cell.

EMX homeobox genes regulate microphthalmia and alter melanocyte biology.

D. Beach, D. Bennett, A. Carnero, 2005, Experimental cell research.

cdc2 is a component of the M phase-specific histone H1 kinase: Evidence for identity with MPF

L. Meijer, D. Beach, L. Brizuela, 1988, Cell.

The Xenopus cdc2 protein is a component of MPF, a cytoplasmic regulator of mitosis

D. Beach, L. Brizuela, J. Newport, 1988, Cell.

Cyclin is a component of the sea urchin egg M‐phase specific histone H1 kinase.

L. Meijer, T. Hunt, J. Pines, 1989, The EMBO journal.

Functionally homologous cell cycle control genes in budding and fission yeast

P. Nurse, D. Beach, B. Durkacz, 1982, Nature.

p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.

K. Kinzler, B. Vogelstein, T. Jacks, 1995, Genes & development.

A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeastSchizosaccharomyces pombe

D. Beach, D. Casso, 1996, Molecular and General Genetics MGG.

Four mating‐type genes control sexual differentiation in the fission yeast.

M. Smith, M. Smith, D. Beach, 1988, The EMBO journal.

Targeting CDK 4 and CDK 6 : From Discovery to Therapy

G. Shapiro, D. Beach, C. Sherr, 2015 .

Polycomb CBX7 has a unifying role in cellular lifespan

D. Beach, D. Bernard, Dolores Martínez, 2004, Nature Cell Biology.

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

G. Hannon, D. Demetrick, D. Beach, 1993, Genes & development.

Advances in Brief Mutations in the p 16 @ ' @ 4 / MTS 1 / CDKN 2 , p 15 @ 4 B / MTS 2 , and p 18 Genes in Primary and Metastatic Lung Cancer '

G. Hannon, A. Okamoto, J. Yokota, 2006 .

The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans

Robert Lowe, Vardhman K. Rakyan, Martha R. Stampfer, 2015, Genome Biology.

Growth-regulated expression of D-type cyclin genes in human diploid fibroblasts.

Y. Xiong, D. Beach, Y. Xiong, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Immortalization of primary human prostate epithelial cells by c-Myc.

J. Cigudosa, G. Peters, D. Beach, 2005, Cancer research.

Frequent Deletion of p16*NK4a/MTSl and in Pediatric Acute Lymphoblastic Leukemia

J. Downing, S. Shurtleff, F. Behm, 2011 .

Association of Rat pl 5 INK 4 Blpl 6 INK 4 Deletions with Monosomy 5 in Kidney Epithelial Cell Lines but not Primary Renal Tumors 1

M. Serrano, D. Beach, C. Walker, 2006 .

Frequent Deletion of p 16 * NK 4 a / MTSl and i Pediatric Acute Lymphoblastic Leukemia

Downing, S. Shurtleff, F. Behm, 2002 .

Involvement of the cyclin-dependent kinase inhibitor p16 (INK4a) in replicative senescence of normal human fibroblasts.

G. Hannon, J. Barrett, D. Beach, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Myc activates telomerase.

G. Hannon, D. Beach, L. Y. Xie, 1998, Genes & development.

A whole genome screen for HIV restriction factors

Áine McKnight, D. Beach, M. Dittmar, 2011, Retrovirology.

The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells

D. Beach, K. Riabowol, G. Draetta, 1989, Cell.

The fission yeast cdc2/cdc13/suc1 protein kinase: Regulation of catalytic activity and nuclear localization

D. Beach, R. Booher, C. Alfa, 1989, Cell.

p53-Independent Role of MDM2 in TGF-β1 Resistance

G. Hannon, D. Beach, K. Dai, 1998 .

Cellular senescence bypass screen identifies new putative tumor suppressor genes

D. Beach, J. Leal, S. Y. Cajal, 2008, Oncogene.

Alteration of cell cycle kinase complexes in human papillomavirus E6- and E7-expressing fibroblasts precedes neoplastic transformation

T. Tlsty, D. Beach, Y. Li, 1996, Journal of virology.

Chromosome mapping of human CDC25A and CDC25B phosphatases.

D. Demetrick, D. Beach, 1993, Genomics.

Shared role of the pRB-related p130 and p107 proteins in limb development.

R. Weinberg, T. Jacks, G. Hannon, 1996, Genes & development.

Cloning and characterization of murine p16INK4a and p15INK4b genes.

G. Hannon, M. Serrano, D. Beach, 1995, Oncogene.

Cellular senescence mediated by p16INK4A-coupled miRNA pathways

Martha R. Stampfer, D. Beach, M. Stampfer, 2013, Nucleic acids research.

The product of the mei3+ gene, expressed under control of the mating‐type locus, induces meiosis and sporulation in fission yeast.

D. Beach, M. McLeod, M. Stein, 1987, The EMBO journal.

Involvement of ras in sexual differentiation but not in growth control in fission yeast

D. Beach, D. Beach, A. Nasim, 1986, The EMBO journal.

Cell biology: Risky immortalization by telomerase

Gregory J. Hannon, G. Hannon, D. Beach, 2000, Nature.

Isolation of . the Rbr . elated p 130 through its mteraeuon w l U l CDK 2 and eyelins

G. Hannon, D. Beach, 2007 .

Monitoring Tumorigenesis and Senescence In Vivo with a p16 INK4a -Luciferase Model

David B. Darr, N. Sharpless, N. Bardeesy, 2013, Cell.

Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD

G. Hannon, A. Lassar, D. Beach, 1995, Science.

A complex containing p34cdc2 and cyclin B phosphorylates the nuclear lamin and disassembles nuclei of clam oocytes in vitro

D. Beach, J. Bischoff, G. Dessev, 1991, The Journal of cell biology.

Characterization of the fission yeast mcs2 cyclin and its associated protein kinase activity.

D. Beach, D. Beach, L. Molz, 1993, The EMBO journal.

p53-dependent association between cyclin G and the B' subunit of protein phosphatase 2A

M. Mumby, C. Prives, D. Beach, 1996, Molecular and cellular biology.

Multiple microRNAs rescue from Ras-induced senescence by inhibiting p21Waf1/Cip1

D. Beach, M. Lleonart, M. Overhoff, 2010, Oncogene.

14-3-3 proteins associate with cdc25 phosphatases.

D. Beach, K. Galaktionov, D. Conklin, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Cyclin in fission yeast

M. Kirschner, D. Beach, M. Solomon, 1988, Cell.

Role of the chromobox protein CBX7 in lymphomagenesis

S. Lowe, T. Visakorpi, D. Mu, 2007, Proceedings of the National Academy of Sciences.

CBX7 controls the growth of normal and tumor-derived prostate cells by repressing the Ink4a/Arf locus

David Beach, Tapio Visakorpi, David Bernard, 2005, Oncogene.

p34cdc2-mediated phosphorylation at T124 inhibits nuclear import of SV- 40 T antigen proteins

D. Beach, D. Beach, J. Bischoff, 1991, The Journal of cell biology.

Genes required for initiation and resolution steps of mating-type switching in fission yeast.

D. Beach, R. Egel, A. Klar, 1984, Proceedings of the National Academy of Sciences of the United States of America.

Rearrangements of the transposable mating‐type cassettes of fission yeast.

D. Beach, A. Klar, A J Klar, 1984, The EMBO journal.

Cell type switching by DNA transposition in fission yeast

D. Beach, David H. Beach, 1983, Nature.

Molecular rearrangement of mating-type genes in fission yeast

P. Nurse, D. Beach, R. Egel, 1982, Nature.

Construction of a Schizosaccharomyces pombe gene bank in a yeast bacterial shuttle vector and its use to isolate genes by complementation

P. Nurse, D. Beach, M. Piper, 2004, Molecular and General Genetics MGG.

Involvement of cdc13+ in mitotic control in Schizosaccharomyces pombe: possible interaction of the gene product with microtubules.

D. Beach, R. Booher, 1988, The EMBO journal.

Construction of an improved host strain for two hybrid screening.

H. Feilotter, G. Hannon, D. Beach, 1994, Nucleic acids research.

Chromosomal mapping of the genes for the human CDK2/cyclin A-associated proteins p19 (SKP1A and SKP1B) and p45 (SKP2).

D. Demetrick, D. Beach, H. Zhang, 1996, Cytogenetics and cell genetics.

Abstracts of papers presented at the 1994 Meeting on the Cell Cycle, May 18-May 22, 1994

David H. Beach, Charles J. Sherr, D. Beach, 1994 .

A mutation in a thioredoxin reductase homolog suppresses p53-induced growth inhibition in the fission yeast

D. Beach, D. Casso, 1996 .

p53-independent role of MDM2 in TGF-beta1 resistance.

G. Hannon, D. Beach, K. Dai, 1998, Science.

Targeting CDK4 and CDK6: From Discovery to Therapy.

G. Shapiro, D. Beach, C. Sherr, 2016, Cancer discovery.

Human p 53 is phosphorylated by p 60-cdc 2 and cyclin B-cdc 2 ( recessive oncogene / p 53 / cell cycle phosphorylation )

D. Beach, J. Bischoff, D. Marshak, 2022 .