J. Keck

发表

NF-kappa B-mediated chromatin reconfiguration and transcriptional activation of the HIV-1 enhancer in vitro.

M. Pazin, J. T. Kadonaga, P. Sheridan, 1996, Genes & development.

Phase 1-2a multicenter dose-escalation study of ezatiostat hydrochloride liposomes for injection (Telintra®, TLK199), a novel glutathione analog prodrug in patients with myelodysplastic syndrome

R. Larson, Z. Estrov, J. Keck, 2009, Journal of hematology & oncology.

The HDAC3–SMARCA4–miR-27a axis promotes expression of the PAX3:FOXO1 fusion oncogene in rhabdomyosarcoma

Noah E. Berlow, Matthew N. Svalina, T. Perkins, 2018, Science Signaling.

Novel cyclooxygenase-1 inhibitors discovered using affinity fingerprints.

P. Beroza, H. Villar, M. Wick, 2004, Journal of medicinal chemistry.

The tandem duplicator phenotype as a distinct genomic configuration in cancer

Jeffrey H. Chuang, E. Liu, A. Malhotra, 2016, Proceedings of the National Academy of Sciences.

Role of DNA replication in vaccinia virus gene expression: A naked template is required for transcription of three late trans-activator genes

B. Moss, J. Keck, C. Baldick, 1990, Cell.

Interactions between coronavirus nucleocapsid protein and viral RNAs: implications for viral transcription

R. Baric, J. Fleming, J. Keck, 1988, Journal of virology.

Mouse hepatitis virus nucleocapsid protein-specific cytotoxic T lymphocytes are Ld restricted and specific for the carboxy terminus

J. Keck, J. Polo, C. Bergmann, 1992, Virology.

High-frequency RNA recombination of murine coronaviruses

M. Lai, J. Keck, S. Makino, 1986, Journal of virology.

Antitumor Activity of Osimertinib, an Irreversible Mutant-Selective EGFR Tyrosine Kinase Inhibitor, in NSCLC Harboring EGFR Exon 20 Insertions

J. Riess, D. Gandara, J. Keck, 2018, Molecular Cancer Therapeutics.

Down Regulation of Gene Expression by the Vaccinia Virus D10 Protein

B. Moss, J. Keck, T. Shors, 1999, Journal of Virology.

Modification of the cascade model for regulation of vaccinia virus gene expression: purification of a prereplicative, late-stage-specific transcription factor

B. Moss, J. Keck, G. Kovacs, 1994, Journal of virology.

Mutational analysis of a predicted zinc-binding motif in the 26-kilodalton protein encoded by the vaccinia virus A2L gene: correlation of zinc binding with late transcriptional transactivation activity

B. Moss, J. Keck, F. Feigenbaum, 1993, Journal of virology.

A transcription factor for expression of vaccinia virus late genes is encoded by an intermediate gene

B. Moss, J. Keck, M. Tsai, 1991, Journal of virology.

Activity of the 17-Kilodalton Protein Encoded by the Vaccinia Virus AlL Gene

B. Moss, J. Keck, G. Kovacs, 2022 .

Mutational analysis of the core, spacer, and initiator regions of vaccinia virus intermediate-class promoters

B. Moss, J. Keck, C. Baldick, 1992, Journal of virology.

Phase I Study of TLK 286 ( Glutathione S-Transferase P 1-1 Activated Glutathione Analogue ) in Advanced Refractory Solid Malignancies 1

J. Keck, R. Lum, S. Schow, 2003 .

Phase I study of TLK286 (glutathione S-transferase P1-1 activated glutathione analogue) in advanced refractory solid malignancies.

J. Keck, R. Lum, S. Schow, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Antitumor efficacy and molecular mechanism of TLK58747, a novel DNA-alkylating prodrug.

J. Keck, Hua Xu, E. Laborde, 2009, Anticancer research.

A rapid, sensitive, and reproducible in vivo PBMC humanized murine model for determining therapeutic‐related cytokine release syndrome

J. Keck, D. Greiner, L. Shultz, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

EphB4/EphrinB2 therapeutics in Rhabdomyosarcoma

Matthew N. Svalina, C. Bult, C. Keller, 2017, PloS one.

Cytoplasmic transcription system encoded by vaccinia virus.

B. Moss, J. Keck, B. Ahn, 1991, The Journal of biological chemistry.

Recombination between nonsegmented RNA genomes of murine coronaviruses

R. Baric, M. Lai, J. Keck, 1985, Journal of virology.

Crimean-Congo Hemorrhagic Fever in Humanized Mice Reveals Glial Cells as Primary Targets of Neurological Infection

J. Keck, A. McElroy, C. Goldsmith, 2017, The Journal of infectious diseases.

Human immune cell engraftment does not alter development of severe acute Rift Valley fever in mice

J. Keck, A. McElroy, S. Nichol, 2018, PloS one.

Phase 1 Study of TLK286 (Telcyta) Administered Weekly in Advanced Malignancies

J. Keck, K. Patel, L. Rosen, 2004, Clinical Cancer Research.

RNA recombination of murine coronaviruses: recombination between fusion-positive mouse hepatitis virus A59 and fusion-negative mouse hepatitis virus 2

M. Lai, J. Keck, S. Makino, 1988, Journal of virology.

Multiple recombination sites at the 5′-end of murine coronavirus RNA

M. Lai, J. Keck, S. Makino, 1987, Virology.

Creation of PDX-Bearing Humanized Mice to Study Immuno-oncology.

J. Keck, M. Brehm, Ken-Edwin Aryee, 2019, Methods in molecular biology.

TLK286, a novel glutathione analog prodrug, induces resensitization to carboplatin in human ovarian cancer, OVCAR3, platinum resistant cells

J. Keck, Hua Xu, G. Brown, 2005 .

In vivo RNA-RNA recombination of coronavirus in mouse brain

J. Fleming, M. Lai, J. Keck, 1988, Journal of virology.

In vitro and in vivo prevention of HIV protease inhibitor‐induced insulin resistance by a novel small molecule insulin receptor activator

J. Keck, R. Lum, S. Schow, 2004, Journal of cellular biochemistry.

Enhanced development of functional human NK cells in NOD‐ scid‐IL2rgnull mice expressing human IL15

J. Keck, D. Greiner, L. Shultz, 2022, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A clustering of rna recombination sites adjacent to a hypervariable region of the peplomer gene of murine coronavirus

M. Lai, J. Keck, L. Banner, 1990, Virology.

Human hepatitis delta antigen is a nuclear phosphoprotein with RNA-binding activity

M. Lai, J. Keck, S. Makino, 1988, Journal of virology.

Abstract B229: Novel ezatiostat analogues disrupt binding of GSTP1 to all three major MAP kinases (JNK, ERK and p38) and exhibit context-dependent antitumor activity.

F. Ali-Osman, J. Keck, R. Turley, 2011 .

Induction of apoptosis by TLK199 in human leukemia cells

J. Keck, A. Raza, G. Brown, 2008 .

Defective-interfering particles of murine coronavirus: Mechanism of synthesis of defective viral RNAs

M. Lai, J. Keck, S. Makino, 1988, Virology.

Daunorubicin-containing CLL1-targeting nanomicelles have anti-leukemia stem cell activity in acute myeloid leukemia.

K. Lam, J. Keck, Q. Long, 2019, Nanomedicine : nanotechnology, biology, and medicine.

RNA recombination of coronaviruses: localization of neutralizing epitopes and neuropathogenic determinants on the carboxyl terminus of peplomers.

J. Fleming, M. Lai, J. Keck, 1987, Proceedings of the National Academy of Sciences of the United States of America.

RNA recombination of coronavirus.

J. Fleming, M. Lai, J. Keck, 1987, Advances in experimental medicine and biology.

Inhibition of murine coronavirus RNA synthesis by hydroxyguanidine derivatives

M. Lai, J. Keck, E. Lien, 1989, Virus Research.

Temporal regulation of bovine coronavirus RNA synthesis

M. Lai, J. Keck, B. Hogue, 1988, Virus Research.

RNA RECOMBINATION OF CORONAVIRUS Summary

J. Fleming, M. Lai, J. Keck, 2012 .

Relationship between cell membrane potential and natural killer cell cytolysis in human hepatocellular carcinoma cells.

J. Keck, R. Binggeli, M. Tong, 1989, Cancer research.

A Genomically and Clinically Annotated Patient-Derived Xenograft Resource for Preclinical Research in Non–Small Cell Lung Cancer

Stephen C. Grubb, Michael W. Lloyd, C. Bult, 2022, bioRxiv.

Design, synthesis, testing, and quantitative structure-activity relationship analysis of substituted salicylaldehyde Schiff bases of 1-amino-3-hydroxyguanidine tosylate as new antiviral agents against coronavirus.

M. Lai, J. Keck, E. Lien, 1990, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.

Joseph L Evans, J. Keck, R. Lum, 2008, Journal of medicinal chemistry.

Humanized mouse models of immunological diseases and precision medicine

J. Keck, J. Keck, D. Greiner, 2019, Mammalian Genome.

Relationship between Cell Membrane Potential and Natural Killer Cell Cytolysis in Human Hepatocellular Carcinoma Cells 1

J. Keck, R. Binggeli, M. Tong, 2006 .

Humanized mouse models for immuno-oncology research

J. Keck, F. Ishikawa, D. Greiner, 2023, Nature Reviews Clinical Oncology.

Abstract 4512: Mouse model for in vivo evaluation of efficacy and potential cytokine release syndrome of chimeric antigen receptor (CAR) T cell therapy

J. Keck, C. Ye, Danying Cai, 2020 .

Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy

J. Banchereau, E. Liu, K. Palucka, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Characterization of monoclonal antibodies to human OC43.

J. Fleming, J. Keck, S. Stohlman, 1987, Advances in experimental medicine and biology.

Development and Characterization of Bladder Cancer Patient-Derived Xenografts for Molecularly Guided Targeted Therapy

C. Bult, E. Liu, C. Tepper, 2015, PloS one.

Preclinical testing of the glycogen synthase kinase-3β inhibitor tideglusib for rhabdomyosarcoma

Noah E. Berlow, Matthew N. Svalina, C. Keller, 2017, Oncotarget.

Alterations in the Rho pathway contribute to Epstein-Barr virus-induced lymphomagenesis in immunosuppressed environments.

Jeffrey H. Chuang, J. Banchereau, E. Liu, 2018, Blood.

Randomized Phase III Study of Canfosfamide in Combination With Pegylated Liposomal Doxorubicin Compared With Pegylated Liposomal Doxorubicin Alone in Platinum-Resistant Ovarian Cancer

I. Vergote, J. Keck, C. Runowicz, 2010, International Journal of Gynecologic Cancer.

Bridging tumor genomics to patient outcomes through an integrated patient-derived xenograft platform.

C. Bult, E. Liu, J. Riess, 2015, Clinical lung cancer.

Severity of Disease in Humanized Mice Infected With Ebola Virus or Reston Virus Is Associated With Magnitude of Early Viral Replication in Liver

H. Feldmann, J. Keck, S. Nichol, 2017, The Journal of infectious diseases.

Transcription of viral late genes is dependent on expression of the viral intermediate gene G8R in cells infected with an inducible conditional-lethal mutant vaccinia virus

B. Moss, J. Keck, Y. Zhang, 1992, Journal of virology.

Ebola Virus Replication and Disease Without Immunopathology in Mice Expressing Transgenes to Support Human Myeloid and Lymphoid Cell Engraftment.

H. Feldmann, J. Keck, S. Nichol, 2016, The Journal of infectious diseases.

Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome.

Scott E. Smith, J. Keck, J. Lancet, 2009, Blood.

Abstract 4150: Novel preclinical model for the evaluation of cytokine release syndrome in response to CD19xCD3 bispecific antibody in humanized mice

J. Keck, Danying Cai, C. Simion, 2023, Cancer Research.

Abstract 4096: Assessing individual variability in efficacy and toxicity of autologous and allogeneic chimeric antigen receptor T-cell immunotherapy using a PBMC-humanized mouse model

J. Keck, D. Rose, Katelyn Burleigh, 2023, Cancer Research.

Abstract 3354: Preclinical evaluation of potential cytokine release syndrome and efficacy of a BCMA-CD3 bispecific antibody for the treatment of multiple myeloma in humanized mice

J. Keck, Hongyuan Yang, Danying Cai, 2020 .

Human genome meeting 2016

A. Pang, W. Chung, J. Lupski, 2016, Human Genomics.

In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution

F. Klawonn, J. Keck, A. Bleich, 2021, Biomedicines.

Phase 1-2a Multicenter Dose-Ranging Study of Canfosfamide in Combination with Carboplatin and Paclitaxel as First-Line Therapy for Patients with Advanced Non-small Cell Lung Cancer

T. Kolevska, L. Sequist, P. Fidias, 2009, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Generation of the NeoThy mouse model for human immune system studies

J. Keck, L. Shultz, M. Brehm, 2023, Lab animal.

Humanized mice (humice) carrying patient-derived xenograft (PDX) as a platform to develop immunotherapy in bladder cancer (BCa).

K. Palucka, J. Keck, S. Airhart, 2017 .

Human genome meeting 2016

Kumar Kshitij Patel, A. Pang, W. Chung, 2016, Human Genomics.

Patient-derived tumor xenografts in humanized NSG-SGM3 mice: A new immuno-oncology platform.

J. Banchereau, J. Riess, K. Palucka, 2016 .

Abstract LB-050: Patient-derived tumor xenografts in humanized NSG mice: a model to study immune responses in cancer therapy

C. Bult, J. Banchereau, K. Palucka, 2015 .

Preclinical rationale for entinostat in embryonal rhabdomyosarcoma

Noah E. Berlow, Matthew N. Svalina, T. Perkins, 2019, Skeletal Muscle.

Antitumor activity of osimertinib in NSCLC harboring EGFR exon 20 insertions.

J. Riess, D. Gandara, J. Keck, 2017 .

Simultaneous evaluation of treatment efficacy and toxicity for bispecific T‐cell engager therapeutics in a humanized mouse model

J. Keck, D. Greiner, L. Shultz, 2023, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Phase 1 multicenter dose-escalation study of ezatiostat hydrochloride (TLK199 tablets), a novel glutathione analog prodrug, in patients with myelodysplastic syndrome.

Scott E. Smith, J. Keck, J. Lancet, 2009, Blood.

Overexpression, purification, and late transcription factor activity of the 17-kilodalton protein encoded by the vaccinia virus A1L gene

B. Moss, J. Keck, G. Kovacs, 1993, Journal of virology.