M. Pancera

发表

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Chaim A. Schramm, Cinque S. Soto, J. Mullikin, 2014, Nature.

Crystal structure , conformational fixation , and entry-related interactions of mature ligand-free HIV-1 Env

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016 .

Analysis of a Clonal Lineage of HIV-1 Envelope V2/V3 Conformational Epitope-Specific Broadly Neutralizing Antibodies and Their Inferred Unmutated Common Ancestors

T. Kepler, H. Liao, J. Sodroski, 2011, Journal of Virology.

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

Young Do Kwon, Tongqing Zhou, Peter D. Kwong, 2009, Proceedings of the National Academy of Sciences.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2011, Nature.

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

Baoshan Zhang, Wayne C Koff, Carole A Bewley, 2013, Nature Structural &Molecular Biology.

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Tongqing Zhou, Ron Diskin, Peter D. Kwong, 2013, Cell.

Vaccine induction of antibodies against a structurally heterogeneous site of immune pressure within HIV-1 envelope protein variable regions 1 and 2.

Guido Ferrari, Jaranit Kaewkungwal, Xiaozhi Lu, 2013, Immunity.

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2016, Cell.

Mining the antibodyome for HIV-1–neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

Baoshan Zhang, Peter D. Kwong, John R. Mascola, 2013, Proceedings of the National Academy of Sciences.

Antibodiesand Their Recognition by Immunotypes of a Quaternary Site of HIV-1

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2014 .

Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2011, Journal of Virology.

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

J. Mascola, T. Zhou, P. Kwong, 2010, Journal of Virology.

Drift of the HIV-1 Envelope Glycoprotein gp120 toward Increased Neutralization Resistance over the Course of the Epidemic: a Comprehensive Study Using the Most Potent and Broadly Neutralizing Monoclonal Antibodies

F. Barin, M. Nussenzweig, A. Moreau, 2014, Journal of Virology.

Identification of a Human Immunodeficiency Virus Type 1 Envelope Glycoprotein Variant Resistant to Cold Inactivation

J. Sodroski, M. Pancera, Amos B. Smith, 2009, Journal of Virology.

Characterization of a vaccine-elicited human antibody with sequence homology to VRC01-class antibodies that binds the C1C2 gp120 domain

L. Stamatatos, D. Montefiori, M. Gray, 2021, bioRxiv.

Somatic Populations of PGT135–137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics

J. Mullikin, J. Mascola, D. Burton, 2012, Front. Microbio..

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

J. Mascola, E. Reinherz, G. Chuang, 2018, Cell reports.

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

Cinque S. Soto, B. Haynes, J. Mascola, 2017, Cell reports.

A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Design of Alphavirus Virus-Like Particles Presenting Circumsporozoite Junctional Epitopes That Elicit Protection against Malaria

J. Mascola, G. Chuang, Baoshan Zhang, 2021, Vaccines.

HIV-1 VRC01 Germline-Targeting Immunogens Select Distinct Epitope-Specific B Cell Receptors.

L. Stamatatos, M. Gray, D. Veesler, 2020, Immunity.

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

M. Pancera, A. Schön, R. Seder, 2021, bioRxiv.

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

L. Stamatatos, M. Gray, A. McGuire, 2018, eLife.

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core.

L. Stamatatos, A. McGuire, D. Veesler, 2018 .

Cross-protective antibodies against common endemic respiratory viruses

M. Gray, M. Pancera, Justin J. Taylor, 2022, bioRxiv.

Highly protective antimalarial antibodies via precision library generation and yeast display screening

Reda Rawi, Chen-Hsiang Shen, Baoshan Zhang, 2022, The Journal of experimental medicine.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

HIV type 1 Env precursor cleavage state affects recognition by both neutralizing and nonneutralizing gp41 antibodies.

J. Mascola, R. Wyatt, K. Mckee, 2011, AIDS research and human retroviruses.

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Speciﬁc Antibodies That Potently Neutralize HIV-1 (cid:1) †§

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2011 .

Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine

Cinque S. Soto, U. Baxa, J. Mascola, 2016 .

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1

D. Ho, M. Nussenzweig, A. Moreau, 2016, Journal of acquired immune deficiency syndromes.

A Potent Anti-Malarial Human Monoclonal Antibody Targets Circumsporozoite Protein Minor Repeats and Neutralizes Sporozoites in the Liver.

Jorgen W. Nelson, D. Baker, R. Gottardo, 2020, Immunity.

Germline‐targeting immunogens

L. Stamatatos, A. McGuire, M. Pancera, 2017, Immunological reviews.

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Lynn Morris, Gwo-Yu Chuang, Peter D. Kwong, 2015, Journal of Virology.

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Crystal structure of glVRC01 scFv in complex with anti-idiotype iv8 scFv

L. Stamatatos, M. Nussenzweig, M. Gray, 2019 .

Immunization with a self-assembling nanoparticle vaccine displaying EBV gH/gL protects humanized mice against lethal viral challenge

B. Stoddard, A. McGuire, D. Veesler, 2022, bioRxiv.

An Antibody Targeting the Fusion Machinery Neutralizes Dual‐Tropic Infection and Defines a Site of Vulnerability on Epstein‐Barr Virus

M. Gray, A. McGuire, D. Veesler, 2018, Immunity.

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

C. Soto, T. Lemmin, Cinque S. Soto, 2016, Science.

Crystal structures of trimeric HIV Env with entry inhibitors BMS-378806 and BMS-626529

Alon Herschhorn, J. Sodroski, J. Mascola, 2017, Nature chemical biology.

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

Alex B. Miller, S. Hoffman, H. Liao, 2018, Nature Medicine.

Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.

Christoph Grundner, Wayne A Hendrickson, Marie Pancera, 2003, Virology.

Overcoming Steric Restrictions of VRC01 HIV-1 Neutralizing Antibodies through Immunization

L. Stamatatos, R. Wyatt, D. Montefiori, 2019, Cell reports.

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Tongqing Zhou, Gary J. Nabel, Peter D. Kwong, 2009, Science.

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

L. Stamatatos, A. McGuire, M. Pancera, 2020, Nature Communications.

Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization

Tongqing Zhou, Lynn Morris, Gwo-Yu Chuang, 2013, Science.

Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit

L. Stamatatos, D. Burton, A. McGuire, 2021, Communications Biology.

Vaccination with Glycan-Modified HIV NFL Envelope Trimer-Liposomes Elicits Broadly Neutralizing Antibodies to Multiple Sites of Vulnerability

J. Mascola, R. Wyatt, R. Bailer, 2019, Immunity.

Soluble Mimetics of Human Immunodeficiency Virus Type 1 Viral Spikes Produced by Replacement of the Native Trimerization Domain with aHeterologous Trimerization Motif: Characterization and Ligand Binding Analysis

J. Sodroski, R. Wyatt, E. Freire, 2005, Journal of Virology.

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Cinque S. Soto, J. Mullikin, B. Haynes, 2015, Cell.

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

J. Foulke, M. Sajadi, P. Acharya, 2014, Journal of Virology.

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-120 interface

Gwo-Yu Chuang, Peter D. Kwong, Richard T. Wyatt, 2014, Nature.

HIV-1 Infection Response Implicated in Reduced Risk for Antibody-Dependent Cellular Cytotoxicity Structural Definition of an

J. Foulke, M. Sajadi, P. Acharya, 2014 .

Factors limiting the immunogenicity of HIV-1 gp120 envelope glycoproteins.

J. Sodroski, R. Wyatt, M. Pancera, 2004, Virology.

Structure and immune recognition of trimeric prefusion HIV-1 Env

Tongqing Zhou, Yongping Yang, Baoshan Zhang, 2014, Nature.

Structures of HIV-1-Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

Jonathan R. McDaniel, Cinque S. Soto, U. Baxa, 2015, Nature Structural &Molecular Biology.

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains

Young Do Kwon, Tongqing Zhou, Gwo-Yu Chuang, 2013, Journal of Virology.

Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies

L. Stamatatos, M. Gray, A. McGuire, 2021, Cell reports.

Characterization of Human Immunodeficiency Virus Type 1 Monomeric and Trimeric gp120 Glycoproteins Stabilized in the CD4-Bound State: Antigenicity, Biophysics, and Immunogenicity

Peter D. Kwong, John R. Mascola, Marie Pancera, 2007, Journal of Virology.

Analysis of a SARS-CoV-2-Infected Individual Reveals Development of Potent Neutralizing Antibodies with Limited Somatic Mutation

L. Stamatatos, A. McGuire, M. McElrath, 2020, Immunity.

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

Baoshan Zhang, Peter D. Kwong, John R. Mascola, 2010, Journal of Virology.

Virus‐like Particles Identify an HIV V1V2 Apex‐Binding Neutralizing Antibody that Lacks a Protruding Loop

T. Kepler, J. Mascola, J. Binley, 2017, Immunity.

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide

T. Kepler, H. Liao, J. Sodroski, 2017, Science Translational Medicine.

Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects

J. Mascola, L. Stamatatos, A. McGuire, 2021, Cell Reports.

Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects

J. Mascola, L. Stamatatos, A. McGuire, 2021, bioRxiv.

Characterization of neutralizing antibodies from a SARS-CoV-2 infected individual

L. Stamatatos, A. McGuire, M. McElrath, 2020, bioRxiv.

Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors.

L. Stamatatos, A. McGuire, D. Sather, 2016, Cell reports.

Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation

L. Stamatatos, A. McGuire, M. Pancera, 2020, bioRxiv.

How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design

P. Kwong, M. Pancera, A. Changela, 2017, Current opinion in HIV and AIDS.

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

Tongqing Zhou, Gwo-Yu Chuang, M. Gordon Joyce, 2017, Journal of Virology.

How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design.

P. Kwong, M. Pancera, A. Changela, 2017, Current opinion in HIV and AIDS.

Selective recognition of oligomeric HIV-1 primary isolate envelope glycoproteins by potently neutralizing ligands requires efficient precursor cleavage.

R. Wyatt, M. Pancera, 2005, Virology.

Structural Biology and the Design of Effective Vaccines for HIV-1 and Other Viruses

M. Sastry, G. Nabel, P. Acharya, 2010, National Institute of Allergy and Infectious Diseases, NIH.

Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes.

L. Stamatatos, A. McGuire, D. Nemazee, 2019 .

Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes

L. Stamatatos, M. Gray, A. McGuire, 2019, The Journal of experimental medicine.

Iterative structure-based improvement of a respiratory syncytial virus fusion glycoprotein vaccine

Cinque S. Soto, U. Baxa, J. Mascola, 2016, Nature Structural &Molecular Biology.

Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility

Young Do Kwon, Tongqing Zhou, Lei Chen, 2009 .

Extensive dissemination and intraclonal maturation of HIV Env vaccine-induced B cell responses

J. Mascola, R. Wyatt, L. Shapiro, 2019, The Journal of experimental medicine.

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env

U. Baxa, J. Mascola, G. Chuang, 2015, Journal of Virology.

Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody

J. Mascola, N. Doria-Rose, P. Kwong, 2015, Journal of Virology.

J. Mascola, R. Wyatt, A. Mileant, 2021, bioRxiv.

Vaccination in a humanized mouse model elicits highly protective PfCSP-targeting anti-malarial antibodies.

G. Chuang, K. Kirsch, Reda Rawi, 2021, Immunity.

Protective antibodies against human parainfluenza virus type 3 infection

A. McGuire, P. Kwong, M. Pancera, 2021, mAbs.

Protective Antibodies Against Human Parainfluenza Virus Type 3 (HPIV3) Infection

A. McGuire, P. Kwong, M. Pancera, 2020, bioRxiv.

Protective Antibodies Against Human Parainfluenza Virus Type 3 (HPIV3) Infection

A. McGuire, P. Kwong, M. Pancera, 2020, bioRxiv.

Multimeric antibodies from antigen-specific human IgM+ memory B cells restrict Plasmodium parasites

Peter D. Crompton, N. King, D. Rawlings, 2021, The Journal of experimental medicine.

A biosensor-based approach toward purification and crystallization of G protein-coupled receptors.

David G Myszka, Marie Pancera, R. Wyatt, 2006, Analytical biochemistry.

The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Alon Herschhorn, Christopher Gu, J. Sodroski, 2017, Nature Communications.

Lineage-Specific Differences between Human and Simian Immunodeficiency Virus Regulation of gp120 Trimer Association and CD4 Binding

Alon Herschhorn, J. Sodroski, P. Kwong, 2012, Journal of Virology.

Transitions to and from the CD4-Bound Conformation Are Modulated by a Single-Residue Change in the Human Immunodeficiency Virus Type 1 gp120 Inner Domain

J. Sodroski, E. Freire, P. Kwong, 2009, Journal of Virology.

Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions.

J. Sodroski, P. Kwong, S. Xiang, 2010, Molecular cell.

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains.

U. Baxa, J. Mascola, G. Chuang, 2017, Cell reports.

Cryo-EM structures of anti-malarial antibody L9 with circumsporozoite protein reveal trimeric L9 association and complete 27-residue epitope.

Chen-Hsiang Shen, Baoshan Zhang, P. Kwong, 2023, Structure.

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

U. Baxa, J. Mascola, I. Georgiev, 2018, ACS infectious diseases.

A Short Segment of the HIV-1 gp120 V1/V2 Region Is a Major Determinant of Resistance to V1/V2 Neutralizing Antibodies

Gwo-Yu Chuang, Peter D. Kwong, Jason S. McLellan, 2012, Journal of Virology.

N332-Directed Broadly Neutralizing Antibodies Use Diverse Modes of HIV-1 Recognition: Inferences from Heavy-Light Chain Complementation of Function

J. Mascola, D. Burton, W. Koff, 2013, PloS one.

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

M. Pancera, K. Liedl, R. Seder, 2022, bioRxiv.

HIV-1 V 1 V 2 antibody with exceptional potency 5 6

Chaim A. Schramm, B. Haynes, G. Chuang, 2015 .

Structures of drug-specific monoclonal antibodies bound to opioids and nicotine reveal a common mode of binding.

A. McGuire, R. Strong, P. Rupert, 2022, Structure.

Structural basis of epitope selectivity and potent protection from malaria by PfCSP antibody L9

M. Pancera, K. Liedl, R. Seder, 2023, Nature Communications.

Symbiotic Nitrogen Fixation in the Fungus Gardens of Leaf-Cutter Ants

David M. Stevenson, Paul J. Weimer, Cameron R. Currie, 2009, Science.

A human monoclonal antibody prevents malaria infection and defines a new site of vulnerability on Plasmodium falciparum circumsporozoite protein

Alex B. Miller, S. Hoffman, H. Liao, 2018 .

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

L. Stamatatos, M. Gray, A. McGuire, 2018, eLife.

Crystal structure of glycosylated 426c HIV-1 gp120 core G459C in complex with glVRC01 A60C heavy chain

L. Stamatatos, A. McGuire, D. Veesler, 2018 .

Structure of iglb12 Fab in complex with anti-idiotype ib3 Fab

L. Stamatatos, A. McGuire, D. Nemazee, 2019 .

Anti-idiotypic antibodies elicit anti-HIV-1–specific B cell responses

L. Stamatatos, M. Nussenzweig, M. Gray, 2019, The Journal of experimental medicine.

Crystal structure, conformational fixation, and entry-related interactions of mature ligand-free HIV-1 Env

James B. Munro, Daniel S. Terry, Cinque S. Soto, 2015, Nature Structural &Molecular Biology.

Publisher Correction: The β20–β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

Alon Herschhorn, Christopher Gu, J. Sodroski, 2018, Nature Communications.

Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies

M. Pancera, M. von Itzstein, G. Hansman, 2023, Journal of virology.

Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2011, Journal of Virology.

Human milk oligosaccharide 2′-fucosyllactose guards norovirus histo-blood group antigen co-factor binding site

M. Pancera, T. Haselhorst, M. von Itzstein, 2024, Journal of virology.