S. Schmidt

发表

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

Chaim A. Schramm, Cinque S. Soto, J. Mullikin, 2014, Nature.

A beta peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease.

P. S. St George-Hyslop, D. Westaway, P. Fraser, 2000, Nature.

In vivo reduction of amyloid-beta by a mutant copper transporter.

P. S. St George-Hyslop, D. Westaway, G. Carlson, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Young Do Kwon, Tongqing Zhou, Baoshan Zhang, 2011, Nature.

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

Young Do Kwon, Tongqing Zhou, Peter D. Kwong, 2012, Proceedings of the National Academy of Sciences.

Alzheimer’s presenilin 1 modulates sorting of APP and its carboxyl‐terminal fragments in cerebral neurons in vivo

M. Ehrlich, S. Gandy, Huaxi Xu, 2007, Journal of neurochemistry.

Cystatin C inhibits amyloid-β deposition in Alzheimer's disease mouse models

D. Radvinsky, S. Schmidt, P. Mathews, 2007, Nature Genetics.

Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

Mario Roederer, Tongqing Zhou, Gary J. Nabel, 2010, Science.

Alzheimer's disease-related overexpression of the cation-dependent mannose 6-phosphate receptor increases Abeta secretion: role for altered lysosomal hydrolase distribution in beta-amyloidogenesis.

J. Rohrer, P. Mehta, M. Mercken, 2002, The Journal of biological chemistry.

A synthetic peptide blocking the apolipoprotein E/beta-amyloid binding mitigates beta-amyloid toxicity and fibril formation in vitro and reduces beta-amyloid plaques in transgenic mice.

D. Holtzman, E. Sigurdsson, T. Wisniewski, 2004, The American journal of pathology.

Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys.

J. Mascola, R. Koup, J. Lifson, 2022, Cell reports.

Glycan-dependent HIV-specific neutralizing antibodies bind to cells of uninfected individuals.

J. Mascola, Eric W Refsland, A. Heredia, 2019, The Journal of clinical investigation.

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

J. Mascola, M. Nussenzweig, J. Lifson, 2016, Nature.

Pathogenicity and Mucosal Transmissibility of the R5-Tropic Simian/Human Immunodeficiency Virus SHIVAD8 in Rhesus Macaques: Implications for Use in Vaccine Studies

J. Mascola, D. Montefiori, B. Keele, 2012, Journal of Virology.

HIV-1 Neutralizing Antibodies Display Dual Recognition of the Primary and Coreceptor Binding Sites and Preferential Binding to Fully Cleaved Envelope Glycoproteins

J. Mascola, R. Wyatt, M. Connors, 2012, Journal of Virology.

Immunotypes of a Quaternary Site of HIV-1 Vulnerability and Their Recognition by Antibodies

J. Mascola, L. Stamatatos, S. Zolla-Pazner, 2011, Journal of Virology.

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

J. Mascola, T. Zhou, P. Kwong, 2010, Journal of Virology.

A Meta-analysis of Passive Immunization Studies Shows that Serum-Neutralizing Antibody Titer Associates with Protection against SHIV Challenge.

Lindsay N. Carpp, N. Haigwood, J. Mascola, 2019, Cell host & microbe.

Staurosporine‐Induced Activation of Caspase‐3 Is Potentiated by Presenilin 1 Familial Alzheimer's Disease Mutations in Human Neuroglioma Cells

R. Tanzi, S. Schmidt, D. Kovacs, 1999, Journal of neurochemistry.

Mature Glycosylation and Trafficking of Nicastrin Modulate Its Binding to Presenilins* 210

P. S. St George-Hyslop, P. Fraser, S. Gandy, 2002, The Journal of Biological Chemistry.

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

Mario Roederer, Tongqing Zhou, Gary J. Nabel, 2017, Science.

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

J. Mascola, E. Reinherz, G. Chuang, 2018, Cell reports.

Protection against a mixed SHIV challenge by a broadly neutralizing antibody cocktail

B. Korber, J. Mascola, D. Burton, 2017, Science Translational Medicine.

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection

J. Mascola, A. Haase, G. Nabel, 2015, Journal of Virology.

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation.

Cinque S. Soto, B. Haynes, J. Mascola, 2017, Cell reports.

Overexpression of human cystatin C in transgenic mice does not affect levels of endogenous brain amyloid β peptide

S. Schmidt, P. Mathews, R. Nixon, 2007, Journal of Molecular Neuroscience.

Development of a 3Mut-Apex-Stabilized Envelope Trimer That Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

J. Mascola, G. Chuang, Y. Lai, 2020, Journal of Virology.

Amarendra Pegu than those to the CD 4 receptor Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo

J. Hoxie, J. Mascola, M. Connors, 2014 .

Marked Calpastatin (CAST) Depletion in Alzheimer's Disease Accelerates Cytoskeleton Disruption and Neurodegeneration: Neuroprotection by CAST Overexpression

V. Haroutunian, S. Schmidt, R. Nixon, 2008, The Journal of Neuroscience.

Calpain Activity Regulates the Cell Surface Distribution of Amyloid Precursor Protein

M. Mercken, S. Schmidt, P. Mathews, 2002, The Journal of Biological Chemistry.

Antibody Persistence through 6 Months after the Second Dose of mRNA-1273 Vaccine for Covid-19

J. Mascola, P. Roberts, N. Doria-Rose, 2021, The New England journal of medicine.

Effect of anti-inflammatory agents on transforming growth factor beta over-expressing mouse brains: a model revised

D. Feinstein, E. Galea, G. Landreth, 2004, Journal of Neuroinflammation.

A meta-analysis of passive immunization studies shows an association of serum neutralizing antibody titer with protection against SHIV challenge

Lindsay N. Carpp, J. Mascola, D. Burton, 2019 .

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

Taina T. Immonen, J. Mascola, P. Bieniasz, 2019, PLoS pathogens.

Protective Efficacy of Broadly Neutralizing Antibodies with Incomplete Neutralization Activity against Simian-Human Immunodeficiency Virus in Rhesus Monkeys

Ruchi M. Newman, Todd M. Allen, T. Allen, 2017, Journal of Virology.

Pathogenicity and Mucosal Transmissibility of the R5-Tropic Simian/Human Immunodeficiency Virus SHIVAD8 in Rhesus Macaques: Implications for Use in Vaccine Studies

J. Mascola, D. Montefiori, B. Keele, 2012, Journal of Virology.

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.

J. Mascola, Yicheng Guo, G. Chuang, 2020, Cell host & microbe.

Aβ measurement by enzyme-linked immunosorbent assay.

S. Schmidt, P. Mathews, R. Nixon, 2012, Methods in molecular biology.

Tissue processing prior to analysis of Alzheimer's disease associated proteins and metabolites, including Aβ.

S. Schmidt, P. Mathews, R. Nixon, 2012, Methods in molecular biology.

Aβ vaccination of a genetic model of Alzheimer's disease

D. Westaway, P. Fraser, P. George-Hyslop, 2003 .

Familial Alzheimer's chromosome 14 mutations

J. Growdon, R. Tanzi, S. Schmidt, 1995, Nature Medicine.

Structural Constraints at the Trimer Apex Stabilize the HIV-1 Envelope in a Closed, Antibody-Protected Conformation

J. Mascola, M. Connors, N. Doria-Rose, 2018, mBio.

Binding and Neutralizing Antibody Responses to SARS-CoV-2 in Infants and Young Children Exceed Those in Adults

R. Karron, F. Dawood, N. Doria-Rose, 2021, medRxiv.

147 Rational Design of Envelope Surface Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1

J. Mascola, R. Wyatt, M. Connors, 2011 .

Aβ is targeted to the vasculature in a mouse model of hereditary cerebral hemorrhage with amyloidosis

Kurt Bürki, Mathias Jucker, M. Staufenbiel, 2004, Nature Neuroscience.

Normal brain development in PS1 hypomorphic mice with markedly reduced γ-secretase cleavage of βAPP

R. Rozmahel, D. Westaway, P. George-Hyslop, 2002, Neurobiology of Aging.

Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype

R. Rozmahel, You-Qiang Song, P. S. St George-Hyslop, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination

J. Mascola, P. Roberts, N. Doria-Rose, 2020, The New England journal of medicine.

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant

M. Diamond, G. Chuang, S. Elbashir, 2022, bioRxiv.

Booster of mRNA-1273 Strengthens SARS-CoV-2 Omicron Neutralization

J. Mascola, D. Montefiori, P. Roberts, 2021, medRxiv.

Macroautophagy—a novel (cid:1) -amyloid peptide-generating pathway activated in Alzheimer’s disease

L. Tjernberg, M. Mercken, S. Schmidt, 2005 .

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness Preview

J. Mascola, R. Baric, S. Elbashir, 2020 .

ELISA Method for Measurement of Amyloid-ß Levels

S. Schmidt, P. Mathews, R. Nixon, 2005 .

Cystatin C inhibits amyloid-beta deposition in Alzheimer's disease mouse models.

D. Radvinsky, S. Schmidt, P. Mathews, 2007, Nature genetics.

Tissue processing prior to protein analysis and amyloid-beta quantitation.

S. Schmidt, P. Mathews, R. Nixon, 2005, Methods in molecular biology.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct γ-secretases

R. Rozmahel, C. Ebeling, D. Westaway, 2005 .

SARS-CoV-2 Omicron Variant Neutralization after mRNA-1273 Booster Vaccination

J. Mascola, D. Montefiori, N. Sullivan, 2022, The New England journal of medicine.

Defining the risk of SARS-CoV-2 variants on immune protection

Larissa B. Thackray, Vineet D. Menachery, Thomas P. Fabrizio, 2022, Nature.

In Vivo Perturbation of Lysosomal Function Promotes Neurodegeneration in the PS1M146V/APPK670N,M671L Mouse Model of Alzheimer's Disease Pathology

H. Sershen, S. Schmidt, P. Mathews, 2002 .

Bivalent SARS-CoV-2 mRNA vaccines increase breadth of neutralization and protect against the BA.5 Omicron variant in mice

Larissa B. Thackray, M. Diamond, G. Chuang, 2022, Nature Medicine.

Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Chaim A. Schramm, Alexander M Schrager, J. Mascola, 2022, bioRxiv.

Safety and Immunogenicity of a Third Dose of SARS-CoV-2 mRNA Vaccine – An Interim Analysis

J. Mascola, D. Montefiori, R. Coler, 2022, Research square.

SARS-CoV-2 mRNA Vaccine Design Enabled by Prototype Pathogen Preparedness

J. Mascola, R. Baric, S. Elbashir, 2020, Nature.

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

J. Mascola, R. Baric, N. Sullivan, 2020, The New England journal of medicine.

SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness

J. Mascola, R. Baric, S. Elbashir, 2020, bioRxiv.

Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults

R. Baric, P. Roberts, N. Doria-Rose, 2020, The New England journal of medicine.

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

J. Mascola, R. Coler, P. Roberts, 2020, The New England journal of medicine.

Inhibition of calpains improves memory and synaptic transmission in a mouse model of Alzheimer disease.

O. Arancio, S. Schmidt, P. Mathews, 2008, The Journal of clinical investigation.

In vivo reduction of amyloid-β by a mutant copper transporter

D. Westaway, G. Carlson, P. George-Hyslop, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

Lynn Morris, Gwo-Yu Chuang, David C Montefiori, 2017, PLoS pathogens.

Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

L. Tjernberg, M. Mercken, S. Schmidt, 2005, The Journal of cell biology.

Alzheimer's Disease-related Overexpression of the Cation-dependent Mannose 6-Phosphate Receptor Increases Aβ Secretion

J. Rohrer, P. Mehta, M. Mercken, 2002, The Journal of Biological Chemistry.

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

Lynn Morris, Gwo-Yu Chuang, Peter D. Kwong, 2015, Journal of Virology.

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

Mario Roederer, Tongqing Zhou, Gary J. Nabel, 2011, Science.

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits.

M. Ohno, P. S. St George-Hyslop, D. Wesson, 2011, Brain : a journal of neurology.

Kerry A. Mullaney, S. Schmidt, P. Mathews, 2009, Proceedings of the National Academy of Sciences.

Rab5-stimulated Up-regulation of the Endocytic Pathway Increases Intracellular β-Cleaved Amyloid Precursor Protein Carboxyl-terminal Fragment Levels and Aβ Production*

S. Schmidt, P. Mathews, R. Nixon, 2003, Journal of Biological Chemistry.

Both the Sequence and Length of the C Terminus of PEN-2 Are Critical for Intermolecular Interactions and Function of Presenilin Complexes*

Hiroshi Hasegawa, Paul M. Mathews, Gerold Schmitt-Ulms, 2004, Journal of Biological Chemistry.

A novel presenilin‐1 mutation: Increased β‐amyloid and neurofibrillary changes

J. Growdon, B. Hyman, R. Tanzi, 1997 .

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

F. Alt, B. Haynes, J. Mascola, 2016, Cell.

Durability of mRNA-1273 vaccine–induced antibodies against SARS-CoV-2 variants

J. Mascola, R. Baric, E. Boritz, 2021, Science.

Convergent epitope specificities, V gene usage and public clones elicited by primary exposure to SARS-CoV-2 variants.

Chaim A. Schramm, Alexander M Schrager, J. Mascola, 2022, bioRxiv : the preprint server for biology.

Gene-Based Vaccination with a Mismatched Envelope Protects against Simian Immunodeficiency Virus Infection in Nonhuman Primates

J. Mascola, N. Letvin, G. Nabel, 2012, Journal of Virology.

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

J. Mascola, D. Baltimore, A. Haase, 2015, Journal of Virology.

Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

J. Mascola, D. Baltimore, A. Haase, 2015 .

Longitudinal dynamics of the HIV-specific B cell response during intermittent treatment of primary HIV infection

J. Mascola, R. Koup, A. McDermott, 2017, PloS one.

The Development of CD4 Binding Site Antibodies during HIV-1 Infection

B. Haynes, J. Mascola, R. Dersimonian, 2012, Journal of Virology.

Antibody-Dependent Cell-Mediated Viral Inhibition Emerges after Simian Immunodeficiency Virus SIVmac251 Infection of Rhesus Monkeys Coincident with gp140-Binding Antibodies and Is Effective against Neutralization-Resistant Viruses

J. Mascola, N. Letvin, S. Schmidt, 2011, Journal of Virology.

Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants

Chaim A. Schramm, J. Mascola, R. Baric, 2021, Science.

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site

J. Mascola, L. Morris, R. Bailer, 2016, Journal of Virology.

Mechanism of Neutralization by the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01

Barney S. Graham, Richard T. Wyatt, John R. Mascola, 2011, Journal of Virology.

Delineating Antibody Recognition in Polyclonal Sera from Patterns of HIV-1 Isolate Neutralization

Tongqing Zhou, Lynn Morris, Gwo-Yu Chuang, 2013, Science.

Limited anti-HIV neutralizing antibody breadth and potency before and after HIV superinfection in Danish men who have sex with men

J. Mascola, T. Quinn, N. Doria-Rose, 2018, Infectious diseases.

Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs

J. Mascola, R. Koup, J. Lifson, 2015, Journal of Virology.

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

Cinque S. Soto, J. Mullikin, B. Haynes, 2015, Cell.

Enhanced Potency of a Broadly Neutralizing HIV-1 Antibody In Vitro Improves Protection against Lentiviral Infection In Vivo

Young Do Kwon, Mario Roederer, Tongqing Zhou, 2014, Journal of Virology.

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Ralph A. Nixon, Paul M. Mathews, Patrick Horne, 2000, Nature.

Enhanced neonatal Fc receptor function improves protection against primate SHIV infection

J. Mascola, A. Haase, G. Nabel, 2014, Nature.

Antibody-Dependent Cell-Mediated Cytotoxicity in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

J. Mascola, N. Letvin, S. Schmidt, 2011, Journal of Virology.

Antibody-Dependent Cell-Mediated Cytotoxicity in Simian Immunodeﬁciency Virus-Infected Rhesus Monkeys (cid:1)

J. Mascola, N. Letvin, S. Schmidt, 2011 .

Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants

J. Mascola, P. Roberts, M. Roederer, 2021, bioRxiv.

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

B. Korber, J. Mascola, D. Burton, 2017, Science Translational Medicine.

Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.

F. Alt, J. Mascola, G. Chuang, 2021, Immunity.

Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys

J. Mascola, M. Connors, R. Koup, 2017, Journal of Virology.

Residue-Level Prediction of HIV-1 Antibody Epitopes Based on Neutralization of Diverse Viral Strains

Young Do Kwon, Tongqing Zhou, Gwo-Yu Chuang, 2013, Journal of Virology.

Binding of cystatin C to Alzheimer’s amyloid β inhibits in vitro amyloid fibril formation

S. Schmidt, P. Mathews, R. Nixon, 2004, Neurobiology of Aging.

, In Vivo Infection Improves Protection against Lentiviral In Vitro Neutralizing HIV-1 Antibody Enhanced Potency of a Broadly

Kyle E. Roberts, Cinque S. Soto, B. Donald, 2014 .

HIV-1 Neutralization Coverage Is Improved by Combining Monoclonal Antibodies That Target Independent Epitopes

Michael S. Seaman, John R. Mascola, Martha Nason, 2012, Journal of Virology.

Aging, gender and APOE isotype modulate metabolism of Alzheimer's Aβ peptides and F2‐isoprostanes in the absence of detectable amyloid deposits

D. Holtzman, T. Montine, R. Martins, 2004, Journal of neurochemistry.

Combination recombinant simian or chimpanzee adenoviral vectors for vaccine development.

J. Mascola, G. Nabel, J. Gall, 2015, Vaccine.

A Cholesterol-Lowering Drug Reduces β-Amyloid Pathology in a Transgenic Mouse Model of Alzheimer's Disease

M. Mercken, S. Schmidt, J. Lafrancois, 2001, Neurobiology of Disease.

mRNA-1273 or mRNA-Omicron boost in vaccinated macaques elicits similar B cell expansion, neutralizing responses, and protection from Omicron

J. Mascola, G. Chuang, D. Douek, 2022, Cell.

Immunization targeting a minor plaque constituent clears β-amyloid and rescues behavioral deficits in an Alzheimer's disease mouse model

D. Wesson, M. Jucker, S. Schmidt, 2013, Neurobiology of Aging.

Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection

J. Mascola, R. Koup, D. Douek, 2015, Science Translational Medicine.

Potent Anti-Viral Activity of a Trispecific HIV Antibody in SHIV-Infected Monkeys

J. Mascola, R. Koup, J. Lifson, 2021, SSRN Electronic Journal.

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

J. Hoxie, J. Mascola, M. Connors, 2014, Science Translational Medicine.

Immunological and Virological Mechanisms of Vaccine-Mediated Protection Against SIV and HIV

Mario Roederer, Raphael Gottardo, Gary J. Nabel, 2013, Nature.

Star nanoparticles delivering HIV-1 peptide minimal immunogens elicit near-native envelope antibody responses in nonhuman primates

B. Haynes, S. Schmidt, R. Parks, 2019, PLoS biology.

Analysis of immunoglobulin transcripts and hypermutation following SHIVAD8 infection and protein-plus-adjuvant immunization

T. Kepler, J. Mullikin, J. Mascola, 2015, Nature Communications.

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting

B. Haynes, J. Mascola, G. Chuang, 2019, PloS one.

Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody

J. Mascola, N. Doria-Rose, P. Kwong, 2015, Journal of Virology.

Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys

M. Hudgens, J. Mascola, D. Montefiori, 2011, Science Translational Medicine.

Longitudinal antibody responses in people who inject drugs infected with similar HIV strains.

J. Weiner, J. Mascola, O. Laeyendecker, 2020, The Journal of infectious diseases.

Protection against SARS-CoV-2 Beta variant in mRNA-1273 vaccine–boosted nonhuman primates

Chaim A. Schramm, J. Mascola, E. Boritz, 2021, Science.

Presenilin Mutations in Familial Alzheimer Disease and Transgenic Mouse Models Accelerate Neuronal Lysosomal Pathology

S. Schmidt, P. Mathews, R. Nixon, 2004, Journal of neuropathology and experimental neurology.

ELISA method for measurement of amyloid-beta levels.

S. Schmidt, P. Mathews, R. Nixon, 2005, Methods in molecular biology.

A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice

Thomas Wisniewski, Paul M. Mathews, Stephen D. Schmidt, 2004 .

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

J. Mascola, I. Georgiev, P. Acharya, 2013, Journal of Virology.

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

M. Ohno, P. S. St George-Hyslop, D. Wesson, 2011, Autophagy.

Tissue Processing Prior to Protein Analysis and Amyloid-ß Quantitation

S. Schmidt, P. Mathews, R. Nixon, 2005 .

Engineering of HIV-1 neutralizing antibody CAP256V2LS for manufacturability and improved half life

J. Mascola, Chen-Hsiang Shen, Baoshan Zhang, 2022, Scientific Reports.

Most rhesus macaques infected with the CCR5-tropic SHIVAD8 generate cross-reactive antibodies that neutralize multiple HIV-1 strains

J. Mascola, D. Montefiori, S. Schmidt, 2012, Proceedings of the National Academy of Sciences.

Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.

R. Rozmahel, P. S. St George-Hyslop, C. Ebeling, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Biochemically Defined HIV-1 Envelope Glycoprotein Variant Immunogens Display Differential Binding and Neutralizing Specificities to the CD4-binding Site*

J. Mascola, R. Wyatt, K. Mckee, 2011, The Journal of Biological Chemistry.

Functional Anatomy of the Trimer Apex Reveals Key Hydrophobic Constraints That Maintain the HIV-1 Envelope Spike in a Closed State

M. Connors, S. Schmidt, Jinghe Huang, 2021, mBio.

Protection against SARS-CoV-2 Beta Variant in mRNA-1273 Boosted Nonhuman Primates

Chaim A. Schramm, J. Mascola, E. Boritz, 2021, bioRxiv.

A b peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer ' s disease

D. Westaway, P. Fraser, P. George-Hyslop, 2022 .

A novel presenilin-1 mutation: increased beta-amyloid and neurofibrillary changes.

M McNamara, B T Hyman, B. Hyman, 1997, Annals of neurology.

Complexes of amyloid-beta and cystatin C in the human central nervous system.

F. Tagliavini, S. Schmidt, P. Mathews, 2009, Journal of Alzheimer's disease : JAD.

HIV-1 V 1 V 2 antibody with exceptional potency 5 6

Chaim A. Schramm, B. Haynes, G. Chuang, 2015 .

Normal brain development in PS1 hypomorphic mice with markedly reduced gamma-secretase cleavage of betaAPP.

R. Rozmahel, P. S. St George-Hyslop, D. Westaway, 2002, Neurobiology of aging.