J. Chaparro-Riggers

发表

Human responses to influenza vaccination show seroconversion signatures and convergent antibody rearrangements.

Mark M. Davis, D. Koller, K. Roskin, 2014, Cell host & microbe.

Thermostable variants constructed via the structure-guided consensus method also show increased stability in salts solutions and homogeneous aqueous-organic media.

J. Chaparro-Riggers, E. Vázquez-Figueroa, V. Yeh, 2008, Protein engineering, design & selection : PEDS.

Structure-guided consensus approach to create a more thermostable penicillin G acylase.

Karen M Polizzi, Andreas S Bommarius, J. Chaparro-Riggers, 2006, Biotechnology journal.

Fabs enable single particle cryoEM studies of small proteins.

Xueming Li, Charles H. Greenberg, Yifan Cheng, 2012, Structure.

Better library design: data‐driven protein engineering

Karen M Polizzi, Andreas S Bommarius, J. Chaparro-Riggers, 2007, Biotechnology journal.

One size does not fit all: navigating the multi-dimensional space to optimize T-cell engaging protein therapeutics

Wei Chen, Xiaodi A Deng, J. Chaparro-Riggers, 2021, mAbs.

Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.

M. Dorywalska, J. Chaparro-Riggers, A. Rajpal, 2013, Chemistry & biology.

Bispecific antibodies for immune cell retargeting against cancer

J. Chaparro-Riggers, K. Shinoda, F. Jin, 2022, Expert opinion on biological therapy.

Preclinical Evaluation of Allogeneic CAR T Cells Targeting BCMA for the Treatment of Multiple Myeloma.

Amy Y. Chen, A. Juillerat, P. Duchateau, 2019, Molecular therapy : the journal of the American Society of Gene Therapy.

Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer

J. Chaparro-Riggers, L. Aschenbrenner, P. Strop, 2019, Scientific Reports.

Preclinical Efficacy and Safety Comparison of CD3 Bispecific and ADC Modalities Targeting BCMA for the Treatment of Multiple Myeloma

Amy Y. Chen, S. Panowski, J. Chaparro-Riggers, 2019, Molecular Cancer Therapeutics.

The neonatal Fc receptor (FcRn) binds independently to both sites of the IgG homodimer with identical affinity

J. Chaparro-Riggers, A. Rajpal, J. Pons, 2015, mAbs.

Dual checkpoint blockade of CD47 and PD-L1 using an affinity-tuned bispecific antibody maximizes antitumor immunity

Shih-Hsun Chen, J. Chaparro-Riggers, S. Salek-Ardakani, 2021, Journal for ImmunoTherapy of Cancer.

CD40 agonist-induced IL-12p40 potentiates hepatotoxicity

J. Chaparro-Riggers, S. Salek-Ardakani, C. Bonnans, 2020, Journal for immunotherapy of cancer.

Modulation of Infectivity in Phage Display as a Tool to Determine the Substrate Specificity of Proteases

U. Bornscheuer, J. Chaparro-Riggers, K. Maurer, 2006, Chembiochem : a European journal of chemical biology.

Comparison of three enoate reductases and their potential use for biotransformations

J. Chaparro-Riggers, E. Vázquez-Figueroa, A. Bommarius, 2007 .

Stability of biocatalysts.

Karen M Polizzi, Andreas S Bommarius, J. Chaparro-Riggers, 2007, Current opinion in chemical biology.

Allogeneic FLT3 CAR T Cells with an Off-Switch Exhibit Potent Activity against AML and Can Be Depleted to Expedite Bone Marrow Recovery.

Danielle E. Dettling, J. Chaparro-Riggers, Y. A. Yeung, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

Direct control of CAR T cells through small molecule-regulated antibodies

Xiaodi A Deng, J. Chaparro-Riggers, J. Pons, 2021, Nature Communications.

Characterization and Comparison of GITR Expression in Solid Tumors

A. Maitra, I. Wistuba, P. Sharma, 2019, Clinical Cancer Research.

Introduction: Antibody Structure and Function

J. Chaparro-Riggers, A. Rajpal, J. Pons, 2013 .

Generating bispecific human IgG1 and IgG2 antibodies from any antibody pair.

Pavel Strop, Arvind Rajpal, J. Chaparro-Riggers, 2012, Journal of molecular biology.

Single nucleotide polymorphisms in the FcγR3A and TAP1 genes impact ADCC in cynomolgus monkey PBMCs

J. Chaparro-Riggers, Y. Abdiche, Hong Wu, 2017, Immunogenetics.

Increasing Serum Half-life and Extending Cholesterol Lowering in Vivo by Engineering Antibody with pH-sensitive Binding to PCSK9*

Rachel M. Devay, J. Chaparro-Riggers, A. Rajpal, 2012, The Journal of Biological Chemistry.

Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire

M. Sirota, Xiaodi A Deng, J. Glanville, 2016, Nature Communications.

An Engineered IL15 Cytokine Mutein Fused to an Anti-PD1 Improves Intratumoral T-cell Function and Antitumor Immunity

M. Dorywalska, K. Ching, L. Mosyak, 2021, Cancer Immunology Research.

An Optimized Full-Length FLT3/CD3 Bispecific Antibody Demonstrates Potent Anti-leukemia Activity and Reversible Hematological Toxicity.

Danielle E. Dettling, J. Chaparro-Riggers, Y. A. Yeung, 2020, Molecular therapy : the journal of the American Society of Gene Therapy.

1 Introduction : Antibody Structure and Function

J. Chaparro-Riggers, A. Rajpal, J. Pons, 2013 .

Ligand-Blocking and Membrane-Proximal Domain Targeting Anti-OX40 Antibodies Mediate Potent T Cell-Stimulatory and Anti-Tumor Activity.

J. Chaparro-Riggers, M. Chu, S. Salek-Ardakani, 2019, Cell reports.

Productive common light chain libraries yield diverse panels of high affinity bispecific antibodies

Marina Sirota, Shobha Potluri, Arvind Rajpal, 2017, mAbs.

Revealing biases inherent in recombination protocols

Karen M Polizzi, Andreas S Bommarius, J. Chaparro-Riggers, 2007, BMC biotechnology.

Precise and efficient antibody epitope determination through library design, yeast display and next-generation sequencing.

Jan Berka, Pavel Strop, Arvind Rajpal, 2015, Journal of molecular biology.

Proprotein Convertase Substilisin/Kexin Type 9 Antagonism Reduces Low-Density Lipoprotein Cholesterol in Statin-Treated Hypercholesterolemic Nonhuman Primates

J. Chaparro-Riggers, A. Rajpal, J. Pons, 2012, Journal of Pharmacology and Experimental Therapeutics.

Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

A. Nager, J. Chaparro-Riggers, S. Salek-Ardakani, 2018, Nature Communications.

High-throughput screening for enhanced protein stability.

Karen M Polizzi, Andreas S Bommarius, J. Chaparro-Riggers, 2006, Current opinion in biotechnology.

Author Correction: Targeting CLDN18.2 by CD3 Bispecific and ADC Modalities for the Treatments of Gastric and Pancreatic Cancer

J. Chaparro-Riggers, L. Aschenbrenner, P. Strop, 2019, Scientific Reports.

A GFP-based assay for the determination of hydrolytic activity and substrate specificity of subtilisins under washing conditions

U. Bornscheuer, J. Chaparro-Riggers, K. Maurer, 2005 .

Preclinical Development and Evaluation of Allogeneic CAR T Cells Targeting CD70 for the Treatment of Renal Cell Carcinoma.

S. Panowski, R. Galetto, J. Chaparro-Riggers, 2022, Cancer research.

Structure of the 4-1BB/4-1BBL complex and distinct binding and functional properties of utomilumab and urelumab

A. Nager, J. Chaparro-Riggers, S. Salek-Ardakani, 2018, Nature Communications.

Structural delineation and phase-dependent activation of the costimulatory CD27:CD70 complex

A. Nager, L. Mosyak, J. Chaparro-Riggers, 2021, The Journal of biological chemistry.

Epitope Mapping Using Yeast Display and Next Generation Sequencing.

J. Berka, J. Chaparro-Riggers, A. Rajpal, 2018, Methods in molecular biology.

Preclinical Evaluation of a Potent Anti-Bcma CD3 Bispecific Molecule for the Treatment of Multiple Myeloma

Amy Y. Chen, Thomas Van Blarcom, S. Panowski, 2016 .

ALLO-715, an Allogeneic BCMA CAR T Therapy Possessing an Off-Switch for the Treatment of Multiple Myeloma

Thomas Van Blarcom, R. Galetto, J. Chaparro-Riggers, 2018, Blood.