G. Chang

发表

A five-gene signature and clinical outcome in non-small-cell lung cancer.

Jeremy J. W. Chen, Chun-Chi Liu, Chih-Yi Chen, 2007, The New England journal of medicine.

Terpinen-4-ol Induces Apoptosis in Human Nonsmall Cell Lung Cancer In Vitro and In Vivo

G. Chang, Chieh-Shan Wu, Yun-Ju Chen, 2011, Evidence-based complementary and alternative medicine : eCAM.

An epidermal growth factor inhibitor, Gefitinib, induces apoptosis through a p53-dependent upregulation of pro-apoptotic molecules and downregulation of anti-apoptotic molecules in human lung adenocarcinoma A549 cells.

G. Chang, S. Hsu, Chun-Chi Wu, 2008, European journal of pharmacology.

Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia

B. Qian, Hongbing Shen, Chien-Jen Chen, 2012, Nature Genetics.

EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women.

Yuh-Min Chen, C. Hsiung, G. Chang, 2013, Carcinogenesis.

Pretreatment epidermal growth factor receptor (EGFR) T790M mutation predicts shorter EGFR tyrosine kinase inhibitor response duration in patients with non-small-cell lung cancer.

Sung-Liang Yu, Ker-Chau Li, Min-Liang Kuo, 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

ATM polymorphisms and risk of lung cancer among never smokers.

Yuh-Shan Jou, Ming-Shyan Huang, Chin-Fu Hsiao, 2010, Lung cancer.

MicroRNA signature predicts survival and relapse in lung cancer.

Sung-Liang Yu, Ching-Cheng Chiang, Ker-Chau Li, 2008, Cancer cell.

A new tumor suppressor DnaJ-like heat shock protein, HLJ1, and survival of patients with non-small-cell lung carcinoma.

Yuh-Shan Jou, Chun-Yi Wu, Wei J Chen, 2006, Journal of the National Cancer Institute.

Molecular gene signature and prognosis of non-small cell lung cancer

Sung-Liang Yu, Chia-Hsin Liu, Hsuan-Yu Chen, 2016, Oncotarget.

Estrogen Receptor Gene Polymorphisms and Lung Adenocarcinoma Risk in Never-Smoking Women

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Hypoxia-induced Slug SUMOylation enhances lung cancer metastasis

Yih-Leong Chang, Chen‐Tu Wu, Sung-Liang Yu, 2019, Journal of Experimental & Clinical Cancer Research.

Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)

Chien-Chung Lin, Li Jin, Nilanjan Chatterjee, 2015, Human Genetics.

EGFR mutation and lobar location of lung adenocarcinoma.

Jeremy J. W. Chen, J. Shih, T. Hsia, 2016, Carcinogenesis.

Surgical Results of Metastatic Spinal Cord Compression Secondary to Non-Small Cell Lung Cancer

G. Chang, Tsung-Ying Yang, H. Hsu, 2007, Spine.

Divergent epidermal growth factor receptor mutation patterns between smokers and non-smokers with lung adenocarcinoma.

Chih-Yi Chen, G. Chang, Tsung-Ying Yang, 2015, Lung cancer.

Real-world Treatment Patterns in Patients with EGFR Mutation-positive NSCLC Receiving a First-Line, First- or Second-generation EGFR Tyrosine Kinase Inhibitor in South Korea and Taiwan

Jae Cheol Lee, J. Shih, Youngchul Kim, 2021, Asian Pacific Journal of Cancer Biology.

Experience from Asian centers in a named-patient-use program for afatinib in patients with advanced non-small-cell lung cancer who had progressed following prior therapies, including patients with uncommon EGFR mutations

J. Shih, Keunchil Park, Yuh-Min Chen, 2021, International Journal of Clinical Oncology.

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

William Wheeler, Hideo Tanaka, Jianxin Shi, 2014, Human molecular genetics.

Sustained activation of ERK and Cdk2/cyclin-A signaling pathway by pemetrexed leading to S-phase arrest and apoptosis in human non-small cell lung cancer A549 cells.

G. Sheu, G. Chang, Tsung-Ying Yang, 2011, European journal of pharmacology.

HLJ1 is an endogenous Src inhibitor suppressing cancer progression through dual mechanisms

J. J. Chen, G. Chang, P-C. Yang, 2016, Oncogene.

The M1/M2 spectrum and plasticity of malignant pleural effusion-macrophage in advanced lung cancer

Ker-Chau Li, G. Chang, Hsiang-Yuan Yeh, 2020, Cancer Immunology, Immunotherapy.

Surface a -Enolase Promotes Extracellular Matrix Degradation and Tumor Metastasis and Represents a New Therapeutic Target

G. Chang, C. Kuo, Tze-Sing Huang, 2013 .

Effectiveness of FDG-PET Scans in the Evaluation of Patients with Single Pulmonary Nodules in Taiwan

G. Chang, Wan-Yu Lin, Shyh-Jen Wang, 2004 .

High efficacy of erlotinib in Taiwanese NSCLC patients in an expanded access program study previously treated with chemotherapy.

Chih-Hsin Yang, H. Kuo, Yuh-Min Chen, 2008, Lung cancer.

Serial-measured versus estimated creatinine clearance in patients with non-small cell lung cancer receiving cisplatin-based chemotherapy.

G. Chang, Tsung-Ying Yang, C. Shih, 2003, Journal of the Formosan Medical Association = Taiwan yi zhi.

Reduced symmetric dimethylation stabilizes vimentin and promotes metastasis in MTAP‐deficient lung cancer

Yu‐Ju Chen, Hsuan-Yu Chen, Sung-Liang Yu, 2022, EMBO reports.

PD-L1 strong expressions affect the clinical outcomes of osimertinib in treatment naïve advanced EGFR-mutant non-small cell lung cancer patients

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2022, Scientific Reports.

Association of Smoking With Patient Characteristics and Outcomes in Small Cell Lung Carcinoma, 2011-2018

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2022, JAMA network open.

Influence of the Timing of Leptomeningeal Metastasis on the Outcome of EGFR-Mutant Lung Adenocarcinoma Patients and Predictors of Detectable EGFR Mutations in Cerebrospinal Fluid

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2022, Cancers.

ASPIRATION: Phase II study of continued erlotinib beyond RECIST progression in Asian patients (pts) with epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer (NSCLC).

M. Ahn, Keunchil Park, T. Mok, 2012 .

EGFR mutation, smoking, and gender in advanced lung adenocarcinoma

Jeremy J. W. Chen, T. Chou, Chun-Ming Tsai, 2017, Oncotarget.

Dynamic Plasma EGFR Mutation Status as a Predictor of EGFR-TKI Efficacy in Patients with EGFR-Mutant Lung Adenocarcinoma

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2015, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Pemetrexed induces both intrinsic and extrinsic apoptosis through ataxia telangiectasia mutated/p53‐dependent and ‐independent signaling pathways

G. Sheu, G. Chang, Tsung-Ying Yang, 2013, Molecular carcinogenesis.

Increased expression of cytochrome P4501B1 in peripheral leukocytes from lung cancer patients.

Hue Lee, G. Chang, P. Lin, 2004, Toxicology letters.

Identification of α-Enolase as an Autoantigen in Lung Cancer: Its Overexpression Is Associated with Clinical Outcomes

J. Whang‐Peng, T. Chou, Chih-Yi Chen, 2006, Clinical Cancer Research.

Good response to gefitinib in a lung adenocarcinoma harboring a heterozygous complex mutation of L833V and H835L in epidermal growth factor receptor gene.

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Effect of Folic Acid and Vitamin B 12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells

G. Sheu, G. Chang, Tsung-Ying Yang, 2015 .

Effect of Folic Acid and Vitamin B12 on Pemetrexed Antifolate Chemotherapy in Nutrient Lung Cancer Cells

G. Sheu, G. Chang, Tsung-Ying Yang, 2013, BioMed research international.

Complications of therapy in cancer patients: Case 1. Paronychia and skin hyperpigmentation induced by gefitinib in advanced non-small-cell lung cancer.

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Characteristics and immune checkpoint inhibitor effects on non-smoking non-small cell lung cancer with KRAS mutation

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2022, Medicine.

Extracellular signal-regulated kinase activation and Bcl-2 downregulation mediate apoptosis after gemcitabine treatment partly via a p53-independent pathway.

G. Sheu, Chih-Yi Chen, G. Chang, 2004, European journal of pharmacology.

Activity of Afatinib in Heavily Pretreated Patients With ERBB2 Mutation–Positive Advanced NSCLC: Findings From a Global Named Patient Use Program

J. Shih, S. Peters, G. Chang, 2018, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Induction of tubulin by docetaxel is associated with p53 status in human non small cell lung cancer cell lines

G. Sheu, J. Ko, Hue Lee, 2006, International journal of cancer.

Association of TNF-alpha polymorphism with susceptibility to and severity of non-small cell lung cancer.

M. Chou, G. Chang, C. Shih, 2006, Lung cancer.

Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

Wen Tan, Chien-Chung Lin, Chang Ho Kim, 2012, Human Genetics.

Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2021, Scientific Reports.

Durvalumab plus platinum–etoposide versus platinum–etoposide in first-line treatment of extensive-stage small-cell lung cancer (CASPIAN): a randomised, controlled, open-label, phase 3 trial

Young Hak Kim, N. Reinmuth, A. Chiang, 2019, The Lancet.

Abstract CT190: A multicenter, open-label, single-arm, phase II study: The third generation EGFR tyrosine kinase inhibitor almonertinib for pretreated EGFR T790M-positive locally advanced or metastatic non-small cell lung cancer (APOLLO)

Ping Wang, Ying Cheng, C. Chiu, 2020 .

Various impacts of driver mutations on the PD-L1 expression of NSCLC

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2022, PloS one.

Genome-wide association study of genetic predictors of overall survival for non-small cell lung cancer in never smokers.

Joe Y. Chang, V Shane Pankratz, Yuanqing Ye, 2013, Cancer research.

Bronchoalveolar interleukin-1&bgr;: A marker of bacterial burden in mechanically ventilated patients with community-acquired pneumonia

M. Niederman, G. Chang, Kai-Ming Chang, 2003, Critical care medicine.

Paronychia and skin hyperpigmentation induced by gefitinib in advanced non-small-cell lung cancer

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2004 .

6610 POSTER Safety of bevacizumab treatment in non-small cell lung cancer (NSCLC) subjects receiving full-dose anti-coagulation (FDAC) treated on protocol BO17704

H. Kuo, G. Chang, N. Leighl, 2007 .

Safety of Bevacizumab Treatment in Non–Small-Cell Lung Cancer (NSCLC) Subjects Receiving Full-Dose Anticoagulation (FDAC) Treated on Protocol BO17704

H. Kuo, G. Chang, N. Leighl, 2007 .

Pemetrexed Induces S-Phase Arrest and Apoptosis via a Deregulated Activation of Akt Signaling Pathway

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2014, PloS one.

Peruvoside is a novel Src inhibitor that suppresses NSCLC cell growth and motility by downregulating multiple Src-EGFR-related pathways.

Jeremy J. W. Chen, G. Chang, Yi-Hua Lai, 2020, American journal of cancer research.

Etiology and cytokine expression in patients requiring mechanical ventilation due to severe community-acquired pneumonia.

G. Chang, M. Chan, Kai-Ming Chang, 2006, Journal of the Formosan Medical Association = Taiwan yi zhi.

Elevated Expression of Lumican in Lung Cancer Cells Promotes Bone Metastasis through an Autocrine Regulatory Mechanism

G. Chang, P. Chu, Ko-Jiunn Liu, 2019, Cancers.

CD4/CD8 Ratio of Pleural Effusion Is A Prognostic Predictor for Non-Small Cell Lung Cancer Patients Under Immune Checkpoint Inhibitor Treatments

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2021 .

Interactions between household air pollution and GWAS-identified lung cancer susceptibility markers in the Female Lung Cancer Consortium in Asia (FLCCA)

Hongbing Shen, Chien-Jen Chen, N. Rothman, 2015, Human Genetics.

Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia

B. Qian, Chien-Jen Chen, N. Rothman, 2012, Human Genetics.

Osimertinib Plus Durvalumab versus Osimertinib Monotherapy in EGFR T790M–Positive NSCLC following Previous EGFR TKI Therapy: CAURAL Brief Report

Sung Sook Lee, F. Shepherd, Dong-Wan Kim, 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Proteogenomics of Non-smoking Lung Cancer in East Asia Delineates Molecular Signatures of Pathogenesis and Progression

I. Jonassen, Yi-Ju Chen, Yih-Leong Chang, 2020, Cell.

Brigatinib versus Crizotinib in ALK‐Positive Non–Small‐Cell Lung Cancer

C. Gridelli, S. Gettinger, M. Ahn, 2018, The New England journal of medicine.

The diagnosis of pneumonia in renal transplant recipients using invasive and noninvasive procedures.

G. Chang, Tsung-Ying Yang, Chieh-Liang Wu, 2004, Chest.

A Four-Gene Signature from NCI-60 Cell Line for Survival Prediction in Non–Small Cell Lung Cancer

Sung-Liang Yu, Chia-Hsin Liu, Ker-Chau Li, 2009, Clinical Cancer Research.

Successful treatment of multifocal bronchioloalveolar cell carcinoma with ZD1839 (Iressa) in two patients.

G. Chang, Tsung-Ying Yang, C. Chiang, 2003, Journal of the Formosan Medical Association = Taiwan yi zhi.

The emergence of T790M mutation in EGFR-mutant lung adenocarcinoma patients having a history of acquired resistance to EGFR-TKI: focus on rebiopsy timing and long-term existence of T790M

Hsuan-Yu Chen, Sung-Liang Yu, G. Chang, 2016, Oncotarget.

Aurora-A promotes gefitinib resistance via a NF-κB signaling pathway in p53 knockdown lung cancer cells.

G. Chang, S. Hsu, Chun-Chi Wu, 2011, Biochemical and biophysical research communications.

JAG1 Is Associated with Poor Survival through Inducing Metastasis in Lung Cancer

Hsuan-Yu Chen, Sung-Liang Yu, G. Chang, 2016, PloS one.

Digoxin Suppresses Tumor Malignancy through Inhibiting Multiple Src-Related Signaling Pathways in Non-Small Cell Lung Cancer

Jeremy J. W. Chen, G. Chang, Yi-Hua Lai, 2015, PloS one.

HOXA5 Inhibits Metastasis via Regulating Cytoskeletal Remodelling and Associates with Prolonged Survival in Non-Small-Cell Lung Carcinoma

Jeremy J. W. Chen, Hsuan-Yu Chen, Sung-Liang Yu, 2015, PloS one.

Identification of Five Driver Gene Mutations in Patients with Treatment-Naïve Lung Adenocarcinoma in Taiwan

Jeremy J. W. Chen, J. Shih, T. Hsia, 2015, PloS one.

Landscape of Mitochondria Genome and Clinical Outcomes in Stage 1 Lung Adenocarcinoma

Jeremy J. W. Chen, Ker-Chau Li, Shin-sheng Yuan, 2020, Cancers.

Tumor mutation burden and recurrent tumors in hereditary lung cancer

Ker-Chau Li, Shin-sheng Yuan, Hsuan-Yu Chen, 2019, Cancer medicine.

High PD-L1 expression correlates with primary resistance to EGFR-TKIs in treatment naïve advanced EGFR-mutant lung adenocarcinoma patients.

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2019, Lung cancer.

Safety and Efficacy of First-Line Bevacizumab with Chemotherapy in Asian Patients with Advanced Nonsquamous NSCLC: Results from the Phase IV MO19390 (SAiL) Study

Yi-long Wu, Chun-Ming Tsai, G. Chang, 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Comparative effectiveness of bevacizumab plus cisplatin‐based chemotherapy versus pemetrexed plus cisplatin treatment in East Asian non‐squamous non‐small cell lung cancer patients applying real‐life outcomes

Stefan Walzer, Myung-Ju Ahn, M. Ahn, 2011, Asia-Pacific journal of clinical oncology.

Efficacy of bevacizumab with cisplatin and gemcitabine in Asian patients with advanced or recurrent non‐squamous non‐small cell lung cancer who have not received prior chemotherapy: A substudy of the Avastin in Lung trial

S. Thongprasert, Chun-Ming Tsai, T. Hsia, 2011, Asia-Pacific journal of clinical oncology.

Cancer-associated fibroblasts regulate the plasticity of lung cancer stemness via paracrine signalling

Ker-Chau Li, Yih-Leong Chang, Shin-sheng Yuan, 2014, Nature Communications.

Genome-Wide Epigenetic Landscape of Lung Adenocarcinoma Links HOXB9 DNA Methylation to Intrinsic EGFR-TKI Resistance and Heterogeneous Responses

Ker-Chau Li, Sung-Liang Yu, G. Chang, 2021, JCO precision oncology.

Clustered genomic alterations in chromosome 7p dictate outcomes and targeted treatment responses of lung adenocarcinoma with EGFR-activating mutations.

Jeremy J. W. Chen, Ker-Chau Li, Y. Lai, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Primary Tumor Resection Is Associated with a Better Outcome among Advanced EGFR-Mutant Lung Adenocarcinoma Patients Receiving EGFR-TKI Treatment

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2020, Oncology.

A Randomized-Controlled Phase 2 Study of the MET Antibody Emibetuzumab in Combination with Erlotinib as First-line Treatment for EGFR-mutation Positive NSCLC Patients.

C. Schumann, N. Girard, G. Scagliotti, 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Intercalated Treatment Following Rebiopsy Is Associated with a Shorter Progression-Free Survival of Osimertinib Treatment

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2017, Cancer research and treatment : official journal of Korean Cancer Association.

Oncogenic miR-137 contributes to cisplatin resistance via repressing CASP3 in lung adenocarcinoma.

Jeremy J. W. Chen, Hsuan-Yu Chen, Sung-Liang Yu, 2016, American journal of cancer research.

Polymorphisms of MLH1 and MSH2 genes and the risk of lung cancer among never smokers.

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2011, Lung cancer.

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women.

X. Hua, Jianxin Shi, Y. Miyagi, 2019, Genomics.

MITF functions as a tumor suppressor in non-small cell lung cancer beyond the canonically oncogenic role

Jeremy J. W. Chen, Hsuan-Yu Chen, Sung-Liang Yu, 2020, Aging.

Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations

Ping Wang, Junjie Wu, Jian Su, 2016, Human molecular genetics.

Meta-analysis of genome-wide association studies identifies multiple lung cancer susceptibility loci in never-smoking Asian women.

Hongbing Shen, Chien-Jen Chen, N. Rothman, 2016, Human molecular genetics.

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for Thirteen Cancer Types.

Jian Su, Wen Tan, Paolo Vineis, 2015, Journal of the National Cancer Institute.

Analysis of Heritability and Shared Heritability Based on Genome-Wide Association Studies for 13 Cancer Types

Alison P. Klein, William Wheeler, Li Jin, 2015 .

The 5p15.33 Locus Is Associated with Risk of Lung Adenocarcinoma in Never-Smoking Females in Asia

Chung K. Chang, Hongbing Shen, N. Rothman, 2010, PLoS genetics.

Surgical-pathologic factors affect long-term outcomes in stage IB (pT2 N0 M0) non-small cell lung cancer: a heterogeneous disease.

G. Chang, Chung-Ping Hsu, Ming-Ching Lee, 2009, The Journal of thoracic and cardiovascular surgery.

A Polymorphism in the APE1 Gene Promoter is Associated with Lung Cancer Risk

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2009, Cancer Epidemiology Biomarkers & Prevention.

Fanconi anemia genes in lung adenocarcinoma- a pathway-wide study on cancer susceptibility

Chien-Jen Chen, Chen-Yang Shen, Chia-Ni Hsiung, 2016, Journal of Biomedical Science.

Association of an EGFR intron 1 SNP with never-smoking female lung adenocarcinoma patients.

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2009, Lung cancer.

Circulating interleukin‐6 level is a prognostic marker for survival in advanced nonsmall cell lung cancer patients treated with chemotherapy

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2013, International journal of cancer.

Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial.

J. Shih, L. Sequist, S. Ou, 2012, The Lancet. Oncology.

Shisa3 is associated with prolonged survival through promoting β-catenin degradation in lung cancer.

Jeremy J. W. Chen, Yih-Leong Chang, Shin-sheng Yuan, 2014, American journal of respiratory and critical care medicine.

Characteristics and Predictive Value of PD-L1 Status in Real-World Non–Small Cell Lung Cancer Patients

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2018, Journal of immunotherapy.

EGFR mutation analysis for prospective patient selection in AURA3 phase III trial of osimertinib versus platinum-pemetrexed in patients with EGFR T790M-positive advanced non-small-cell lung cancer.

Yi-long Wu, G. Chang, A. Delmonte, 2018, Lung cancer.

S‐1 plus cisplatin as first‐line treatment of patients with advanced non‐small cell lung cancer in Taiwan

Yuh-Min Chen, T. Hsia, G. Chang, 2019, Asia-Pacific journal of clinical oncology.

ASTRIS: a global real-world study of osimertinib in >3000 patients with EGFR T790M positive non-small-cell lung cancer.

Yi-long Wu, J. Rigas, Yuh-Min Chen, 2019, Future oncology.

An Observational Study on Treatment Outcomes in Patients With Stage III NSCLC in Taiwan: The KINDLE Study

J. Shih, Yuh-Min Chen, T. Hsia, 2022, JTO Clinical and Research Reports.

Primary Tumor Radiotherapy During EGFR-TKI Disease Control Improves Survival of Treatment Naïve Advanced EGFR-Mutant Lung Adenocarcinoma Patients

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2021, OncoTargets and therapy.

Impact of tumor disappearance ratio on the prognosis of lung adenocarcinoma ≤2 cm in size: A retrospective cohort study.

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2020, Journal of the Formosan Medical Association = Taiwan yi zhi.

Higher frequency but random distribution of EGFR mutation subtypes in familial lung cancer patients

Jeremy J. W. Chen, T. Hsia, Hsuan-Yu Chen, 2016, Oncotarget.

R331W Missense Mutation of Oncogene YAP1 Is a Germline Risk Allele for Lung Adenocarcinoma With Medical Actionability.

Jeremy J. W. Chen, Ker-Chau Li, Chien-Jen Chen, 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

The Motor Protein KIF14 Inhibits Tumor Growth and Cancer Metastasis in Lung Adenocarcinoma

Yih-Leong Chang, Chen‐Tu Wu, Hsuan-Yu Chen, 2013, PloS one.

Hybrid Pharmacophore- and Structure-Based Virtual Screening Pipeline to Identify Novel EGFR Inhibitors That Suppress Non-Small Cell Lung Cancer Cell Growth

Jeremy J. W. Chen, G. Chang, Yi-Hua Lai, 2022, International journal of molecular sciences.

Molecular mechanisms of ZD1839-induced G1-cell cycle arrest and apoptosis in human lung adenocarcinoma A549 cells.

G. Sheu, G. Chang, S. Hsu, 2004, Biochemical pharmacology.

Curcumin Induces EGFR Degradation in Lung Adenocarcinoma and Modulates p38 Activation in Intestine: The Versatile Adjuvant for Gefitinib Therapy

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2011, PloS one.

Claudin-1 is a metastasis suppressor and correlates with clinical outcome in lung adenocarcinoma.

Sung-Liang Yu, Chung-Wu Lin, Yu-Chih Chao, 2009, American journal of respiratory and critical care medicine.

ALK variants, PD-L1 expression, and their association with outcomes in ALK-positive NSCLC patients

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2020, Scientific Reports.

Activity of gefitinib in advanced non-small-cell lung cancer with very poor performance status

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2004, Investigational New Drugs.

A Randomized Phase 2 Study Comparing the Combination of Ficlatuzumab and Gefitinib with Gefitinib Alone in Asian Patients with Advanced Stage Pulmonary Adenocarcinoma

Keunchil Park, T. Mok, E. Tan, 2016, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Rhodomycin A, a novel Src-targeted compound, can suppress lung cancer cell progression via modulating Src-related pathways

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2015, Oncotarget.

Real-world efficacy and safety of lorlatinib in treating advanced ALK-positive non–small cell lung cancer patients

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2021, Anti-cancer drugs.

The impact of different first-line EGFR-TKIs on the clinical outcome of sequential osimertinib treatment in advanced NSCLC with secondary T790M

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2021, Scientific Reports.

The relative importance of predictive factors for single first-generation EGFR-TKI use for more than 5 years in patients with advanced non-small cell lung cancer: Taiwan multicenter TIPS-5 study

T. Hsia, Sung-Liang Yu, G. Chang, 2021, Therapeutic advances in medical oncology.

Phase I results of S49076 plus gefitinib in patients with EGFR TKI-resistant non-small cell lung cancer harbouring MET/AXL dysregulation.

Keunchil Park, G. Curigliano, G. Chang, 2021, Lung cancer.

Safety, Efficacy and Pharmacokinetics of Almonertinib (HS-10296) in Pretreated Patients with EGFR-mutated Advanced NSCLC: a Multicenter, Open-label, Phase I Trial.

C. Chiu, T. Hsia, D. Camidge, 2020, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Integrative Omics Analysis Reveals Soluble Cadherin-3 as a Survival Predictor and an Early Monitoring Marker of EGFR Tyrosine Kinase Inhibitor Therapy in Lung Cancer

G. Chang, Jau-Song Yu, K. Chien, 2020, Clinical Cancer Research.

Genetic Modifiers of Progression‐Free Survival in Never‐Smoking Lung Adenocarcinoma Patients Treated with First‐Line Tyrosine Kinase Inhibitors

Jih-Hsiang Lee, Chien-Jen Chen, N. Rothman, 2017, American journal of respiratory and critical care medicine.

Predictive factors for EGFR-tyrosine kinase inhibitor retreatment in patients with EGFR-mutated non-small-cell lung cancer - A multicenter retrospective SEQUENCE study.

C. Tu, Yuh-Min Chen, T. Hsia, 2017, Lung cancer.

Impact of EGFR Mutation Detection Methods on the Efficacy of Erlotinib in Patients with Advanced EGFR-Wild Type Lung Adenocarcinoma

Yuh-Min Chen, Sung-Liang Yu, G. Chang, 2014, PloS one.

Prior EGFR tyrosine-kinase inhibitor therapy did not influence the efficacy of subsequent pemetrexed plus platinum in advanced chemonaïve patients with EGFR-mutant lung adenocarcinoma

Jeremy J. W. Chen, Hsuan-Yu Chen, Sung-Liang Yu, 2014, OncoTargets and therapy.

Clinical and Testing Protocols for the Analysis of Epidermal Growth Factor Receptor Mutations in East Asian Patients with Non-small Cell Lung Cancer: A Combined Clinical-Molecular Pathological Approach

Jie Yang, M. Salto‐Tellez, J. Shih, 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Survival outcome and predictors of gefitinib antitumor activity in East Asian chemonaive patients with advanced nonsmall cell lung cancer

J. Shih, Chiun Hsu, G. Chang, 2006, Cancer.

EGFR exon 19 in‐frame deletion and polymorphisms of DNA repair genes in never‐smoking female lung adenocarcinoma patients

Chen-Yang Shen, Yuh-Min Chen, C. Hsiung, 2013, International journal of cancer.

Epidermal Growth Factor Receptor Mutation Status in Stage I Lung Adenocarcinoma with Different Image Patterns

Chien-Jen Chen, T. Chou, Yuh-Min Chen, 2011, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

The Association of Acquired T790M Mutation with Clinical Characteristics after Resistance to First-Line Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor in Lung Adenocarcinoma

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2018, Cancer research and treatment : official journal of Korean Cancer Association.

Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-cell lung cancer (FASTACT-2): a randomised, double-blind trial.

Li Zhang, Hongming Pan, Chong-Jen Yu, 2013, The Lancet. Oncology.

Retrospective study of erlotinib in patients with advanced squamous lung cancer.

Hsuan-Yu Chen, G. Chang, Tsung-Ying Yang, 2012, Lung cancer.

Paired-like homeodomain 2B contributes to tumour progression and anti-autophagy in human lung cancer.

Jeremy J. W. Chen, Hsuan-Yu Chen, Sung-Liang Yu, 2021, American journal of cancer research.

Sub-multiplicative interaction between polygenic risk score and household coal use in relation to lung adenocarcinoma among never-smoking women in Asia.

Jianxin Shi, Hongbing Shen, N. Rothman, 2020, Environment international.

Programmed Death Ligand 2 Gene Polymorphisms Are Associated With Lung Adenocarcinoma Risk in Female Never-Smokers

Yuh-Min Chen, C. Hsiung, S. Jiang, 2021, Frontiers in Oncology.

Impact of cooking oil fume exposure and fume extractor use on lung cancer risk in non-smoking Han Chinese women

Yuh-Min Chen, C. Hsiung, G. Chang, 2020, Scientific Reports.

Predicting Lung Cancer Occurrence in Never-Smoking Females in Asia: TNSF-SQ, a Prediction Model

N. Rothman, S. Chanock, N. Chatterjee, 2019, Cancer Epidemiology, Biomarkers & Prevention.

Genetic variants associated with longer telomere length are associated with increased lung cancer risk among never‐smoking women in Asia: a report from the female lung cancer consortium in Asia

B. Qian, Hongbing Shen, Chien-Jen Chen, 2015, International journal of cancer.

Risk factors for primary lung cancer among never smokers by gender in a matched case–control study

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2013, Cancer Causes & Control.

The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion

Jeremy J. W. Chen, Meng-Feng Tsai, Jeremy J W Chen, 2005, Oncogene.

A pilot clinical trial of vaccination with dendritic cells pulsed with autologous tumor cells derived from malignant pleural effusion in patients with late‐stage lung carcinoma

J. Whang‐Peng, G. Chang, Ko-Jiunn Liu, 2005, Cancer.

HLJ1 is a novel caspase-3 substrate and its expression enhances UV-induced apoptosis in non-small cell lung carcinoma

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2010, Nucleic acids research.

Genetic Polymorphism of XRCC1 Arg399Gln Is Associated With Survival in Non–Small-Cell Lung Cancer Patients Treated With Gemcitabine/Platinum

J. Shih, Yuh-Min Chen, G. Chang, 2012, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Tumor microenvironment-based screening repurposes drugs targeting cancer stem cells and cancer-associated fibroblasts

Jeremy J. W. Chen, Ker-Chau Li, Hsuan-Yu Chen, 2021, Theranostics.

The Relationship Between Air Pollution and Lung Cancer in Nonsmokers in Taiwan

Sung-Liang Yu, G. Chang, Tsung-Ying Yang, 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Characteristics of young lung cancer: Analysis of Taiwan's nationwide lung cancer registry focusing on epidermal growth factor receptor mutation and smoking status

T. Chou, C. Chiu, Chun-Ming Tsai, 2016, Oncotarget.

An Observational Study of Acquired EGFR T790M-Dependent Resistance to EGFR-TKI Treatment in Lung Adenocarcinoma Patients in Taiwan

J. Shih, T. Hsia, G. Chang, 2020, Frontiers in Oncology.

Phase III study of gemcitabine and cisplatin with or without aprinocarsen, a protein kinase C-alpha antisense oligonucleotide, in patients with advanced-stage non-small-cell lung cancer.

José Miguel Reyes, Jean-Yves Douillard, Michael Lahn, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Long-Term Survival Effect of the Interval between Postoperative Chemotherapy and Radiotherapy in Patients with Completely Resected Pathological N2 Non-Small-Cell Lung Cancer

G. Chang, H. Ku, T. Liu, 2021, Cancers.

Recalibrating Risk Prediction Models by Synthesizing Data Sources: Adapting the Lung Cancer PLCO Model for Taiwan

N. Rothman, Yuh-Min Chen, C. Hsiung, 2022, Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.

EGFR-activating mutations, DNA copy number abundance of ErbB family, and prognosis in lung adenocarcinoma

Ker-Chau Li, Hsuan-Yu Chen, Sung-Liang Yu, 2016, Oncotarget.

Risk factors for primary lung cancer among never smokers by gender in a matched case–control study

Yuh-Min Chen, C. Hsiung, G. Chang, 2012, Cancer Causes & Control.

Local Metastases Along the Tract of Needle: A Rare Complication of Vertebroplasty in Treating Spinal Metastases

G. Chang, H. Hsu, Tu-Sheng Lee, 2007, Spine.

Antiplatelet agents and anticoagulants increased the bleeding risk of bedside percutaneous dilational tracheostomy in critically ill patients.

G. Chang, M. Chan, Bor-Jen Lee, 2020, Journal of the Formosan Medical Association = Taiwan yi zhi.

EGFR over-expression in non-small cell lung cancers harboring EGFR mutations is associated with marked down-regulation of CD82.

S. Tsai, G. Chang, Shiu-Feng Huang, 2015, Biochimica et biophysica acta.

Tumor and Stem Cell Biology Cancer Research Tumor Suppressor HLJ 1 Binds and Functionally Alters Nucleophosmin via Activating Enhancer Binding Protein 2 α Complex Formation

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2010 .

Osimertinib for pretreated EGFR Thr790Met-positive advanced non-small-cell lung cancer (AURA2): a multicentre, open-label, single-arm, phase 2 study.

T. Mitsudomi, F. Shepherd, L. Crinò, 2016, The Lancet. Oncology.

Anti-alpha-enolase autoantibodies are down-regulated in advanced cancer patients.

G. Chang, Yu-Chung Wu, Hsien-Chih Lin, 2010, Japanese journal of clinical oncology.

Interactive effect of cigarette smoking with human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) polymorphisms on the risk of lung cancer: a case-control study in Taiwan.

Ming-Shyan Huang, Chin-Fu Hsiao, Chin-Hao Chang, 2009, American journal of epidemiology.

Original Contribution Interactive Effect of Cigarette Smoking With Human 8-Oxoguanine DNA N-Glycosylase 1 (hOGG1) Polymorphisms on the Risk of Lung Cancer: A Case-Control Study in Taiwan

Chien-Jen Chen, Yuh-Min Chen, G. Chang, 2009 .

Association of TNF-α polymorphism with susceptibility to and severity of non-small cell lung cancer

Wei Chen, Ming-Chih Chou, M. Chou, 2006 .

RAGE acts as an oncogenic role and promotes the metastasis of human lung cancer

G. Chang, Tsung-Ying Yang, C. Teng, 2020, Cell Death & Disease.

EGFR L858R Mutation and Polymorphisms of Genes Related to Estrogen Biosynthesis and Metabolism in Never-Smoking Female Lung Adenocarcinoma Patients

Chen-Yang Shen, Yuh-Min Chen, C. Hsiung, 2011, Clinical Cancer Research.

EGFR L 858 R Mutation and Polymorphisms of Genes related to Estrogen Biosynthesis and Metabolism in Never-smoking Female Lung Adenocarcinoma Patients

Chien-Jen Chen, Chen-Yang Shen, Yuh-Min Chen, 2011 .

Nivolumab safety and efficacy in advanced, platinum-resistant, non-small cell lung cancer, radical radiotherapy-ineligible patients: A phase II study in Taiwan.

C. Chiu, Yuh-Min Chen, T. Hsia, 2020, Journal of the Formosan Medical Association = Taiwan yi zhi.

Exercise experiences in patients with metastatic lung cancer: A qualitative approach

G. Chang, Y. Lai, Yun-Hsiang Lee, 2020, PloS one.

Alteration of autoantibodies against p53 in Taiwanese lung cancer patients undergoing chemotherapy.

G. Chang, C. Shih, Yao-Ling Lee, 2004, Clinica chimica acta; international journal of clinical chemistry.

Predilection of contralateral upper lung metastasis in upper lobe lung adenocarcinoma patients.

Jeremy J. W. Chen, Hsuan-Yu Chen, Sung-Liang Yu, 2016, Journal of thoracic disease.

Predictive Factors of Gefitinib Antitumor Activity in East Asian Advanced Non-small Cell Lung Cancer Patients

J. Shih, C. Chiu, R. Perng, 2006, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Mutational monitoring of EGFR T790M in cfDNA for clinical outcome prediction in EGFR-mutant lung adenocarcinoma

Sung-Liang Yu, G. Chang, Pan‐Chyr Yang, 2018, PloS one.

Clinical patterns among invasive pulmonary aspergillosis patients with and without recent intensive immunosuppressive therapy.

G. Chang, C. Chiang, C. L. Wu, 2001, Journal of the Formosan Medical Association = Taiwan yi zhi.

Hormone replacement therapy and lung cancer risk in Chinese

Chien-Jen Chen, R. Perng, C. Hsiung, 2007, Cancer.

Revisit of 1997 TNM staging system--survival analysis of 1112 lung cancer patients in Taiwan.

Jen-Jyh Lee, C. Chiu, Yuh-Min Chen, 2007, Japanese journal of clinical oncology.

Inhibition of Alternative Cancer Cell Metabolism of EGFR Mutated Non-Small Cell Lung Cancer Serves as a Potential Therapeutic Strategy

G. Chang, Hui-Wen Chang, Chung-Yu Huang, 2020, Cancers.

The Clinical Outcomes of Different First-Line EGFR-TKIs Plus Bevacizumab in Advanced EGFR-Mutant Lung Adenocarcinoma

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2021, Cancer research and treatment.

Phosphatase of regenerating liver-3 inhibits invasiveness and proliferation in non-small cell lung cancer by regulating the epithelial-mesenchymal transition

Jeremy J. W. Chen, Sung-Liang Yu, G. Chang, 2016, Oncotarget.

FAM198B Is Associated with Prolonged Survival and Inhibits Metastasis in Lung Adenocarcinoma via Blockage of ERK-Mediated MMP-1 Expression

Hsuan-Yu Chen, Sung-Liang Yu, G. Chang, 2017, Clinical Cancer Research.

Genome-wide association study of lung adenocarcinoma in East Asia and comparison with a European population

L. Kiemeney, Y. Miyagi, B. Qian, 2023, Nature communications.

Pharmacophore-based virtual screening for the identification of the novel Src inhibitor SJG-136 against lung cancer cell growth and motility.

Jeremy J. W. Chen, G. Chang, Chun-Chi Liu, 2020, American journal of cancer research.

Asian Subgroup Analysis of the Randomized Phase 3 CROWN Study of First-Line Lorlatinib Versus Crizotinib in Advanced ALK-Positive NSCLC

C. Chiu, Dong-Wan Kim, G. Chang, 2023, JTO clinical and research reports.

Transformations First Into Squamous-Cell Carcinoma and Later Into Sarcomatoid Carcinoma After Acquired Resistance to Osimertinib in a Patient With EGFR-Mutant Lung Adenocarcinoma: Case Report.

G. Chang, Po-Hsin Lee, 2020, Clinical lung cancer.

A Polymorphism in the APE 1 Gene Promoter is Associated with Lung Cancer Risk

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2008 .

Impact of cooking oil fume exposure and fume extractor use on lung cancer risk in non-smoking Han Chinese women

Chien-Jen Chen, Yuh-Min Chen, C. Hsiung, 2020, Scientific Reports.

Evaluation of combination treatment with DS-1205c, an AXL kinase inhibitor, and osimertinib in metastatic or unresectable EGFR-mutant non-small cell lung cancer: results from a multicenter, open-label phase 1 study

Jie Yang, C. Chiu, T. Hsia, 2023, Investigational New Drugs.

PCN10 COST-EFFCTIVENESS ANALYSIS OF ERLOTINIB COMPARED WITH DOCETAXEL AND PEMETREXED FOR SECOND-LINE TREATMENT OF ADVANCED NON-SMALL CELL LUNG CANCER (NSCLC) IN TAIWAN

T. Hsia, G. Chang, W. Su, 2007 .

Anti-α-enolase is a prognostic marker in postoperative lung cancer patients

G. Chang, P. Chu, Ko-Jiunn Liu, 2015, Oncotarget.

OA02.03 The Third Generation EGFR Inhibitor (EGFR-TKI) HS-10296 in Advanced NSCLC Patients with Resistance to First Generation EGFR-TKI

J. Fang, T. Hsia, J. Chen, 2019, Journal of Thoracic Oncology.

ANA positivity and complement level in pleural fluid are potential diagnostic markers in discriminating lupus pleuritis from pleural effusion of other aetiologies

Jeremy J. W. Chen, G. Chang, Tsung-Ying Yang, 2021, Lupus Science & Medicine.

Whole exome sequencing and MicroRNA profiling of lung adenocarcinoma identified risk prediction features for tumors at stage I and its substages.

Shin-sheng Yuan, Hsuan-Yu Chen, Sung-Liang Yu, 2023, Lung cancer.

Second-line pemetrexed treatment in Taiwanese patients with advanced nonsmall cell lung cancer: an open-label single-arm study.

T. Hsia, G. Chang, R. Abdulnabi, 2013, Journal of the Formosan Medical Association = Taiwan yi zhi.

SPANXA suppresses EMT by inhibiting c-JUN/SNAI2 signaling in lung adenocarcinoma

Hsuan-Yu Chen, Sung-Liang Yu, G. Chang, 2016, Oncotarget.

EGFR polymorphisms, hormone replacement therapy and lung adenocarcinoma risk: analysis from a genome-wide association study in never-smoking women.

Yuh-Min Chen, C. Hsiung, G. Chang, 2013, Carcinogenesis.

Hepatitis B flare during osimertinib targeted therapy in a lung cancer patient with a resolved hepatitis B virus infection.

G. Chang, Teng‐Yu Lee, Po-Hsin Lee, 2020, European journal of cancer.

Divergent epidermal growth factor receptor mutation patterns between smokers and non-smokers with lung adenocarcinoma.

G. Chang, Tsung-Ying Yang, Kun-Chieh Chen, 2015, Lung cancer.

Imputation and subset-based association analysis across different cancer types identifies multiple independent risk loci in the TERT-CLPTM1L region on chromosome 5p15.33.

David M. Thomas, Krista A. Zanetti, Geoffrey S. Tobias, 2014, Human molecular genetics.

Elevated Expression of Lumican in Lung Cancer Cells Promotes Bone Metastasis through an Autocrine Regulatory Mechanism

G. Chang, P. Chu, Ko-Jiunn Liu, 2020, Cancers.