Hao Sun

发表

Structure‐based Drug Metabolism Predictions for Drug Design

Hao Sun, D. Scott, 2010, Chemical biology & drug design.

Inhibitor design for SARS coronavirus main protease based on "distorted key theory".

Kuo-Chen Chou, Hao Sun, Qi-Shi Du, 2007, Medicinal chemistry (Shariqah (United Arab Emirates)).

Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions

Hao Sun, J. Halpert, Santosh Kumar, 2009, Drug Metabolism and Disposition.

Sigma-1 Receptor Agonist TS-157 Improves Motor Functional Recovery by Promoting Neurite Outgrowth and pERK in Rats with Focal Cerebral Ischemia

Hao Sun, Jie Tang, Fan Yang, 2021, Molecules.

Using Crystal Structures of Drug‐Metabolizing Enzymes in Mechanism‐Based Modeling for Drug Design

Hao Sun, D. Scott, 2020 .

Bioavailability, Biotransformation, and Excretion of the Covalent Bruton Tyrosine Kinase Inhibitor Acalabrutinib in Rats, Dogs, and Humans

Hao Sun, J. G. Slatter, M. Sanghvi, 2018, Drug Metabolism and Disposition.

Metabolism and Disposition of [14C]BMS-690514 after Oral Administration to Rats, Rabbits, and Dogs

W. Humphreys, V. Roongta, Hao Sun, 2010, Drug Metabolism and Disposition.

Discovery of Selective Small Molecule Inhibitors of Monoacylglycerol Acyltransferase 3.

C. C. Jorgensen, Hao Sun, M. Boehm, 2015, Journal of medicinal chemistry.

Phase 1 study to evaluate the absorption, metabolism and excretion of the NAV1.7-selective sodium channel blocker BIIB074

M. Versavel, Lin Xu, Hao Sun, 2018 .

Synthesis of a Tweezer-like Bis(phenylthiapropoxy)calix[4]-arene as a Cation/π Enhanced Sensor for Ion-Selective Electrodes

Hao Sun, Qing-Shan Li, Xiwen He, 2010 .

Synthesis of a tweezer-like bis(arylthiaalkoxy)calix[4]arene as a cation sensor for ion-selective electrodes: an investigation of the influence of neighboring halogen atoms on cation selectivity.

Hao Sun, Xiwen He, Langxing Chen, 2003, Organic & biomolecular chemistry.

Novel bis(phenylselenoalkoxy)calix[4]arene molecular tweezer receptors as sensors for ion-selective electrodes

Hao Sun, Qing-Shan Li, Xiwen He, 2002 .

Development of Novel Alkoxyisoxazoles as Sigma-1 Receptor Antagonists with Antinociceptive Efficacy.

Hao Sun, Jie Tang, Fan Yang, 2016, Journal of medicinal chemistry.

Asymmetric synthesis of novel N-(1-phenyl-2,3-dihydroxypropyl)arachidonylamides and evaluation of their anti-inflammatory activity.

Hao Sun, Guigen Li, S. Burstein, 2013, Life sciences.

Discovery of N-cyclobutylaminoethoxyisoxazole derivatives as novel sigma-1 receptor ligands with neurite outgrowth efficacy in cells

Hao Sun, Jie Tang, Fan Yang, 2018, RSC advances.

Systematic and pairwise analysis of the effects of aromatic halogenation and trifluoromethyl substitution on human liver microsomal clearance.

Christopher E. Keefer, Hao Sun, D. Scott, 2011, Drug metabolism letters.

Metabolism of 4-Aminopiperidine Drugs by Cytochrome P450s: Molecular and Quantum Mechanical Insights into Drug Design

Hao Sun, D. Scott, 2011, ACS medicinal chemistry letters.

Synthesis and antioxidant activity of a series of novel 3-chalcone-substituted 1,4-dihydropyridine derivatives

Hao Sun, Longfei Jin, Chengxiang Shang, 2012 .

Dehydrogenation of the Indoline-Containing Drug, Indapamide, by CYP3A4: Correlation with in silico Predictions

Hao Sun, J. Halpert, Santosh Kumar, 2008 .

Phenoxo-O bridged dinuclear lanthanide complexes based on a multitooth Schiff base ligand: Structures, fluorescence properties and single-molecule magnet behavior

Hao Sun, Lina Wu, L. Yali, 2016 .

Structure and Photochemical Properties of r‐1, c‐2, t‐3, t‐4‐l, 3‐Bis [2‐ (5‐R‐benzoxazolyl) ] −2,4‐di (4‐R' ‐phenyl) cyclobutane

Hao Sun, Wenqin Zhang, Jun‐Peng Zhuang, 2010 .

Metabolic activation of a novel 3-substituted indole-containing TNF-alpha inhibitor: dehydrogenation and inactivation of CYP3A4.

Hao Sun, Hao Sun, G. Yost, 2008, Chemical research in toxicology.

Biotransformation of steroidal saponins in sisal (Agave sisalana Perrine) to tigogenin by a newly isolated strain from a karst area of Guilin, China

Hao Sun, Yanchao Wang, Jinlong Zheng, 2014, Biotechnology, biotechnological equipment.

Effect of Structural Variation on Aldehyde Oxidase-Catalyzed Oxidation of Zoniporide

Hao Sun, D. Dalvie, Qiyue Hu, 2012, Drug Metabolism and Disposition.

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

Hao Sun, A. Kalgutkar, R. Obach, 2012, Journal of medicinal chemistry.

Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs

J. Warmus, Hao Sun, A. Vaz, 2018, PloS one.

Metabolism and Disposition of [14C]BMS-690514, an ErbB/Vascular Endothelial Growth Factor Receptor Inhibitor, after Oral Administration to Humans

W. Humphreys, V. Roongta, C. Harbison, 2010, Drug Metabolism and Disposition.

Single mutations change CYP2F3 from a dehydrogenase of 3-methylindole to an oxygenase.

Eric F. Johnson, Hao Sun, C. Reilly, 2008, Biochemistry.

Dehydrogenation of Indoline by Cytochrome P450 Enzymes: A Novel “Aromatase” Process

Hao Sun, P. Kulanthaivel, C. Reilly, 2007, Journal of Pharmacology and Experimental Therapeutics.

Impact of genetic polymorphisms of cytochrome P450 2 C (CYP2C) enzymes on the drug metabolism and design of antidiabetics.

Hao Sun, D. Scott, 2011, Chemico-biological interactions.

Determination of gibberellins in soybean using tertiary amine labeling and capillary electrophoresis coupled with electrochemiluminescence detection.

Hao Sun, Zaibin Hao, W. Luo, 2013, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Synthesis and Pharmacological Evaluation of σ2 Receptor Ligands Based on a 3‐Alkoxyisoxazole Scaffold: Potential Antitumor Effects against Osteosarcoma

Jian Luo, Hao Sun, Fan Yang, 2020, ChemMedChem.

Metabolism, Excretion, and Pharmacokinetics of ((3,3-Difluoropyrrolidin-1-yl)((2S,4S)-4-(4-(pyrimidin-2-yl)piperazin-1-yl)pyrrolidin-2-yl)methanone, a Dipeptidyl Peptidase Inhibitor, in Rat, Dog and Human

C. Prakash, Hao Sun, Tim F. Ryder, 2012, Drug Metabolism and Disposition.

Abstract 13: Structure elucidation, metabolism, and drug interaction potential of ACP-5862, an active, major, circulating metabolite of acalabrutinib

Hao Sun, J. G. Slatter, P. Pearson, 2019, Cancer Chemistry.

Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.

Daniel P. Walker, J. Bauman, A. Kalgutkar, 2010, Chemical research in toxicology.

Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.

L. Pustilnik, A. Stepan, R. Obach, 2011, Journal of medicinal chemistry.

Insights from modeling the 3D structure of H5N1 influenza virus neuraminidase and its binding interactions with ligands.

Kuo-Chen Chou, Dong-Qing Wei, Hao Sun, 2006, Biochemical and biophysical research communications.

Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism.

Hao Sun, 2012, Bioorganic & medicinal chemistry letters.

Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.

A. Kalgutkar, R. Obach, Hao Sun, 2012, Journal of medicinal chemistry.

Dirlotapide as a model substrate to refine structure-based drug design strategies on CYP3A4-catalyzed metabolism.

Hao Sun, A. Vaz, A. Bessire, 2012, Bioorganic & medicinal chemistry letters.

Excretion, Metabolism, and Pharmacokinetics of 1-(8-(2-Chlorophenyl)-9-(4-Chlorophenyl)-9H-Purin-6-yl)-4-(Ethylamino)Piperidine-4-Carboxamide, a Selective Cannabinoid Receptor Antagonist, in Healthy Male Volunteers

C. Prakash, Hao Sun, J. Liras, 2012, Drug Metabolism and Disposition.

Dehydrogenation of the Indoline-Containing Drug, Indapamide, by CYP3A4: Correlation with in silico Predictions

Hao Sun, J. Halpert, Santosh Kumar, 2008 .

Differences in CYP3A4 catalyzed bioactivation of 5-aminooxindole and 5-aminobenzsultam scaffolds in proline-rich tyrosine kinase 2 (PYK2) inhibitors: retrospective analysis by CYP3A4 molecular docking, quantum chemical calculations and glutathione adduct detection using linear ion trap/orbitrap mass

Daniel P. Walker, J. Bauman, A. Kalgutkar, 2009, Bioorganic & medicinal chemistry letters.