Brock T Brown

发表

HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay

T. Chung, X. Chan, Brock T Brown, 2010 .

Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.

R. Spreafico, John Calvin Reed, Brock T Brown, 2011, Chemistry and Biology.

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

T. Chung, Brock T Brown, M. Hedrick, 2014, Bioorganic & medicinal chemistry letters.

The regulation of feeding and metabolic rate and the prevention of murine cancer cachexia with a small-molecule melanocortin-4 receptor antagonist.

Brock T Brown, D. Marks, S. Hoare, 2005, Endocrinology.

Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation

John Calvin Reed, Brock T Brown, G. Roth, 2011, ACS medicinal chemistry letters.

Table 4, Probe and Analog Submissions to MLSMR (BioFocus DPI) for Gli-Sufu Antagonist ML340

Santhi Ganji, Ian Pass, Robert Ardecky, 2014 .

Small-molecule antagonists of Gli function

Tram A. Ngo, Jennifer K. T. Casabar, T. Chung, 2014 .

Functional Antagonists of EBI-2

M. Jackson, T. Chung, Brock T Brown, 2015 .

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding.

Brock T Brown, M. Hedrick, E. Sergienko, 2010, Biochemical and biophysical research communications.

Development of a Testing Funnel for Identification of Small-Molecule Modulators Targeting Secretin Receptors

Brock T Brown, E. Sergienko, L. Miller, 2020, SLAS discovery : advancing life sciences R & D.

High-Throughput Fluorescence Polarization Assay for Chemical Library Screening against Anti-Apoptotic Bcl-2 Family Member Bfl-1

John Calvin Reed, T. Chung, X. Chan, 2012, Journal of biomolecular screening.

Table 1, SAR results generated using analogue-by-catalogue (ABC)

Layton H. Smith, Thomas D.Y. Chung, Eduard Sergienko, 2010 .

Potent imidazole and triazole CB1 receptor antagonists related to SR141716.

Teresa Y. Phillips, Brock T Brown, B. Dyck, 2004, Bioorganic & medicinal chemistry letters.

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Brock T Brown, J. Millán, E. Sergienko, 2009, Bioorganic & medicinal chemistry letters.

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Brock T Brown, J. Millán, E. Sergienko, 2009, Journal of medicinal chemistry.

Identification and Characterization of Novel Tissue-Nonspecific Alkaline Phosphatase Inhibitors with Diverse Modes of Action

X. Chan, Brock T Brown, J. Millán, 2009, Journal of biomolecular screening.

Capzimin is a potent and specific inhibitor of proteasome isopeptidase Rpn11.

Seth M. Cohen, T. Chung, R. Deshaies, 2017, Nature chemical biology.

Discovery of small molecule positive allosteric modulators of the secretin receptor.

Brock T Brown, E. Sergienko, L. Miller, 2021, Biochemical pharmacology.

Single amino acid residue determinants of non-peptide antagonist binding to the corticotropin-releasing factor1 (CRF1) receptor.

S. Betz, Brock T Brown, D. Grigoriadis, 2006, Biochemical pharmacology.

Inhibition of Bfl-1 with N-aryl maleimides.

John Calvin Reed, J. Cashman, Brock T Brown, 2010, Bioorganic & medicinal chemistry letters.

Inhibition of Hematopoietic Protein Tyrosine Phosphatase Augments and Prolongs ERK1/2 and p38 Activation

T. Mustelin, T. Chung, Li Yang, 2012, ACS chemical biology.

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.

H. Freeze, Brock T Brown, M. Hedrick, 2011, Journal of medicinal chemistry.

Discovery and characterization of 2-aminobenzimidazole derivatives as selective NOD1 inhibitors.

R. Spreafico, John Calvin Reed, Brock T Brown, 2011, Chemistry & biology.

High Throughput Screening Assays for NOD1 Inhibitors - Probe 2

John Calvin Reed, T. Chung, Brock T Brown, 2010 .