M. Hedrick

发表

HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay

T. Chung, X. Chan, Brock T Brown, 2010 .

A simple, high-resolution method for establishing DNA binding affinity and sequence selectivity.

D. Boger, M. Hedrick, B. Fink, 2001, Journal of the American Chemical Society.

High-Throughput Screening for Norepinephrine Transporter Inhibitors Using the FLIPRTetra

M. Hedrick, D. Disepio, Ryan Wagstaff, 2007, Journal of biomolecular screening.

Exceptionally potent inhibitors of fatty acid amide hydrolase: the enzyme responsible for degradation of endogenous oleamide and anandamide.

D. Boger, B. Cravatt, M. Hedrick, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Behavioral evidence for the interaction of oleamide with multiple neurotransmitter systems.

D. Boger, M. Hedrick, K. Rice, 2001, The Journal of pharmacology and experimental therapeutics.

α-Keto heterocycle inhibitors of fatty acid amide hydrolase: carbonyl group modification and α-substitution

D. Boger, M. Hedrick, H. Miyauchi, 2001 .

β-Arrestin-Biased Allosteric Modulator of NTSR1 Selectively Attenuates Addictive Behaviors

W. Wetsel, M. Caron, A. Badea, 2020, Cell.

Establishment of substituent effects in the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

D. Boger, M. Hedrick, F. Stauffer, 2003, Bioorganic & medicinal chemistry.

Discovery of 4-oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate (ML221) as a functional antagonist of the apelin (APJ) receptor.

T. Chung, M. Hedrick, E. Sergienko, 2012, Bioorganic & medicinal chemistry letters.

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

T. Chung, Brock T Brown, M. Hedrick, 2014, Bioorganic & medicinal chemistry letters.

Table 1, Listing of all Assays and AIDs for this project

Susanne Heynen-Genel, Shenghua Shi, Thomas D.Y. Chung, 2010 .

Assessment of solution-phase positional scanning libraries based on distamycin A for the discovery of new DNA binding agents.

D. Boger, M. Hedrick, B. Fink, 2000, Bioorganic & medicinal chemistry.

α‐Keto Heterocycle Inhibitors of Fatty Acid Amide Hydrolase: Carbonyl Group Modification and α‐Substitution.

D. Boger, M. Hedrick, H. Miyauchi, 2001 .

High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding.

Brock T Brown, M. Hedrick, E. Sergienko, 2010, Biochemical and biophysical research communications.

Screening for Selective Ligands for GPR55 - Antagonists

M. Caron, T. Chung, M. Hedrick, 2011 .

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway.

D. Boger, I. Wilson, S. Benkovic, 2002, Bioorganic & medicinal chemistry.

Substituent effects within the DNA binding subunit of CBI analogues of the duocarmycins and CC-1065.

D. Boger, M. Hedrick, F. Stauffer, 2001, Bioorganic & medicinal chemistry letters.

Identification and Characterization of Novel Human Glucose-6-Phosphate Dehydrogenase Inhibitors

S. Rahlfs, K. Becker, M. Hedrick, 2013, Journal of biomolecular screening.

N‐Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

T. Chung, M. Hedrick, Benjamin Neuenswander, 2016, ChemMedChem.

Synthesis, chemical properties, and biological evaluation of CC-1065 and duocarmycin analogues incorporating the 5-methoxycarbonyl-1,2,9,9a-tetrahydrocyclopropa.

D. Boger, M. Hedrick, T. V. Hughes, 2001, The Journal of organic chemistry.

Total synthesis of ningalin B utilizing a heterocyclic azadiene Diels-Alder reaction and discovery of a new class of potent multidrug resistant (MDR) reversal agents.

D. Boger, M. Hedrick, Q. Jin, 2000, The Journal of organic chemistry.

Multidrug resistance reversal activity of key ningalin analogues.

D. Boger, M. Hedrick, I. Hwang, 2003, Bioorganic & medicinal chemistry letters.

Total Synthesis of Distamycin A and 2640 Analogues: A Solution-Phase Combinatorial Approach to the Discovery of New, Bioactive DNA Binding Agents and Development of a Rapid, High-Throughput Screen for Determining Relative DNA Binding Affinity or DNA Binding Sequence Selectivity

Michael Hedrick, Dale L. Boger, D. Boger, 2000 .

Discovery of a Plasmodium falciparum glucose-6-phosphate dehydrogenase 6-phosphogluconolactonase inhibitor (R,Z)-N-((1-ethylpyrrolidin-2-yl)methyl)-2-(2-fluorobenzylidene)-3-oxo-3,4-dihydro-2H-benzo[b][1,4]thiazine-6-carboxamide (ML276) that reduces parasite growth in vitro.

Stefan Vasile, Eigo Suyama, Michael Vicchiarelli, 2012, Journal of medicinal chemistry.

Total syntheses of thiocoraline and BE-22179 and assessment of their DNA binding and biological properties.

D. Boger, M. Hedrick, W. Tse, 2001, Journal of the American Chemical Society.

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase.

J. H. Shim, D. Boger, S. Benkovic, 2000, Bioorganic & medicinal chemistry.

Discovery of a potent, selective, and efficacious class of reversible alpha-ketoheterocycle inhibitors of fatty acid amide hydrolase effective as analgesics.

D. Boger, W. L. Jorgensen, O. Acevedo, 2005, Journal of medicinal chemistry.

A new class of highly cytotoxic diketopiperazines.

D. Boger, M. Hedrick, B. Fink, 2000, Bioorganic & medicinal chemistry letters.

Parallel synthesis and evaluation of 132 (+)-1,2,9,9a-tetrahydrocyclopropa[c]benz[e]indol-4-one (CBI) analogues of CC-1065 and the duocarmycins defining the contribution of the DNA-binding domain.

D. Boger, M. Hedrick, B. Fink, 2001, The Journal of organic chemistry.

Evidence That the DNA Endonuclease ARTEMIS also Has Intrinsic 5′-Exonuclease Activity*

K. Schwarz, M. Lieber, M. Hedrick, 2014, The Journal of Biological Chemistry.

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

D. Boger, I. Wilson, S. Benkovic, 2003, Bioorganic & medicinal chemistry.

ML314: A Biased Neurotensin Receptor Ligand for Methamphetamine Abuse.

R. Rodriguiz, W. Wetsel, M. Caron, 2016, ACS chemical biology.

Discovery of ML314, a Brain Penetrant Non-Peptidic β-Arrestin Biased Agonist of the Neurotensin NTR1 Receptor.

M. Caron, T. Chung, M. Hedrick, 2013, ACS medicinal chemistry letters.

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase.

D. Boger, I. Wilson, S. Benkovic, 2003, Bioorganic & medicinal chemistry.

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid.

Stephen J Benkovic, Yan Zhang, Ali Tavassoli, 2003, Biochemistry.

Design, synthesis, and biological evaluation of fluoronitrophenyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase.

J. H. Shim, D. Boger, S. Benkovic, 2000, Bioorganic & medicinal chemistry letters.

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

M. Caron, T. Chung, M. Hedrick, 2012, ACS chemical neuroscience.

Small Molecules Targeting the Mitochondrial Permeability Transition

M. Jackson, T. Chung, D. Bourdette, 2015 .

Combination treatment of the oral CHK1 inhibitor, SRA737 and low dose gemcitabine, enhances the effect of PD-L1 blockade by modulating the immune microenvironment in small cell lung cancer.

Jing Wang, L. Byers, M. Hedrick, 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

Discovery of Sulfonamidebenzamides as Selective Apoptotic CHOP Pathway Activators of the Unfolded Protein Response

Jennifer E. Golden, T. Chung, R. Kaufman, 2014, ACS medicinal chemistry letters.

Functional Agonists of the Apelin (APJ) Receptor

T. Chung, M. Hedrick, E. Sergienko, 2013 .

High-Throughput Screening for Small-Molecule Inhibitors of Plasmodium falciparum Glucose-6-Phosphate Dehydrogenase 6-Phosphogluconolactonase

S. Rahlfs, K. Becker, M. Hedrick, 2012, Journal of biomolecular screening.

Diabetes reversal by inhibition of the low molecular weight tyrosine phosphatase

R. Liddington, N. Bottini, T. Mustelin, 2017, Nature chemical biology.

Potent, selective, and orally available benzoisothiazolone phosphomannose isomerase inhibitors as probes for congenital disorder of glycosylation Ia.

H. Freeze, Brock T Brown, M. Hedrick, 2011, Journal of medicinal chemistry.

Brain-penetrating 2-aminobenzimidazole H(1)-antihistamines for the treatment of insomnia.

Siobhan Malany, Michael Hedrick, Jenny Wen, 2009, Bioorganic & medicinal chemistry letters.

An Optimized Dihydrodibenzothiazepine Lead Compound (SBI-0797750) as a Potent and Selective Inhibitor of Plasmodium falciparum and P. vivax Glucose 6-Phosphate Dehydrogenase 6-Phosphogluconolactonase

S. Rahlfs, T. Chung, M. Hedrick, 2022, Antimicrobial agents and chemotherapy.

Discovery of b-Arrestin Biased, Orally Bioavailable and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators.

M. Jackson, M. Caron, T. Chung, 2019, Journal of medicinal chemistry.

Discovery of Orally Bioavailable Purine-Based Inhibitors of the Low-Molecular-Weight Protein Tyrosine Phosphatase.

M. Jackson, Z. J. Holmes, N. Bottini, 2021, Journal of medicinal chemistry.

Development and use of a high-throughput screen to identify novel modulators of the corticotropin releasing factor binding protein

A. Bonci, D. Sheffler, M. Hedrick, 2022, SLAS discovery : advancing life sciences R & D.

A New Class of Highly Cytotoxic Diketopiperazines

D. Boger, M. Hedrick, B. Fink, 2000 .

Probing the CXCR6/CXCL16 Axis: Targeting Prevention of Prostate Cancer Metastasis

R. Taichman, T. Chung, M. Hedrick, 2014 .

N‐Phenylbenzamides as Potent Inhibitors of the Mitochondrial Permeability Transition Pore

T. Chung, M. Hedrick, Benjamin Neuenswander, 2016, ChemMedChem.

Polytherapie avec des anticorps anti-cd73

M. Hedrick, R. Altura, Ed Hilt, 2017 .