J. Millán

发表

HTS identification of compounds activating TNAP at an intermediate concentration of phosphate acceptor detected in luminescent assay

T. Chung, X. Chan, Brock T Brown, 2010 .

Role of Cytochrome c in Apoptosis: Increased Sensitivity to Tumor Necrosis Factor Alpha Is Associated with Respiratory Defects but Not with Lack of Cytochrome c Release

J. Millán, L. Boise, C. Moraes, 2007, Molecular and Cellular Biology.

Overlapping functions of bone sialoprotein and pyrophosphate regulators in directing cementogenesis.

J. Millán, M. Somerman, E. Chu, 2017, Bone.

Vascular calcification is dependent on plasma levels of pyrophosphate

J. Millán, W. C. O'Neill, S. Narisawa, 2014, Kidney international.

Extracellular pyrophosphate metabolism and calcification in vascular smooth muscle.

G. Dubyak, J. Millán, W. C. O'Neill, 2011, American journal of physiology. Heart and circulatory physiology.

Linked Deficiencies in Extracellular PPi and Osteopontin Mediate Pathologic Calcification Associated With Defective PC‐1 and ANK Expression

R. Terkeltaub, J. Millán, J. Goding, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Unique coexpression in osteoblasts of broadly expressed genes accounts for the spatial restriction of ECM mineralization to bone.

M. McKee, J. Millán, G. Karsenty, 2005, Genes & development.

Osteoconductivity and osteoinductivity of NanoFUSE® DBM

J. Millán, S. Narisawa, J. Kirk, 2012, Cell and Tissue Banking.

Identification of altered brain metabolites associated with TNAP activity in a mouse model of hypophosphatasia using untargeted NMR‐based metabolomics analysis

L. Nowak, C. Fonta, J. Millán, 2017, Journal of neurochemistry.

Tissue-nonspecific alkaline phosphatase deficiency causes abnormal craniofacial bone development in the Alpl(-/-) mouse model of infantile hypophosphatasia.

J. Millán, N. Hatch, Jin Liu, 2014 .

Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization

R. Terkeltaub, H. Anderson, J. Millán, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Alkaline Phosphatases

J. Millán, 2006, Purinergic Signalling.

Regenerative capacity in newts is not altered by repeated regeneration and ageing

J. Millán, P. Tsonis, G. Eguchi, 2011, Nature communications.

Alternative splicing of CREB and CREM mRNAs in an immortalized germ cell line.

J. Millán, M. Meistrich, B. Sanborn, 1997, Journal of andrology.

Disruption of the podosome adaptor protein TKS4 (SH3PXD2B) causes the skeletal dysplasia, eye, and cardiac abnormalities of Frank-Ter Haar Syndrome.

J. Veltman, P. Ruiz-Lozano, R. Hennekam, 2010, American journal of human genetics.

Osteopontin regulates dentin and alveolar bone development and mineralization.

J. Millán, M. Somerman, E. Chu, 2018, Bone.

Multisystemic functions of alkaline phosphatases.

J. Millán, D. Magne, R. Buchet, 2013, Methods in molecular biology.

Conditional Alpl Ablation Phenocopies Dental Defects of Hypophosphatasia

J. Millán, R. Sah, M. Somerman, 2017, Journal of dental research.

Bone Alkaline Phosphatase and Tartrate-Resistant Acid Phosphatase: Potential Co-regulators of Bone Mineralization

J. Millán, G. Andersson, S. Narisawa, 2017, Calcified Tissue International.

Immortalization of germ cells and somatic testicular cells using the SV40 large T antigen.

J. Millán, M. Hofmann, R. Hess, 1992, Experimental cell research.

Coamplification of DAD-R, SOX5, and EKI1 in human testicular seminomas, with specific overexpression of DAD-R, correlates with reduced levels of apoptosis and earlier clinical manifestation.

L. Looijenga, H. Stoop, J. Millán, 2002, Cancer research.

Successful gene therapy in utero for lethal murine hypophosphatasia.

J. Millán, M. Migita, T. Shimada, 2012, Human gene therapy.

PHOSPHO1 is a skeletal regulator of insulin resistance and obesity

J. Millán, K. Suchacki, C. Farquharson, 2020, BMC biology.

Refinement of placental alkaline phosphatase complexed with nitrophenyl

B. Stec, J. Millán, A. Cheltsov, 2011 .

Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.

B. Stec, J. Millán, A. Cheltsov, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Alkaline Phosphatase and Hypophosphatasia

J. Millán, M. Whyte, 2015, Calcified Tissue International.

Deficiency of the bone mineralization inhibitor NPP1 protects mice against obesity and diabetes

J. Millán, C. Farquharson, V. Macrae, 2014, Disease Models & Mechanisms.

Differential Expression of Alkaline Phosphatase and PHOSPHO1 in Bone from a Murine Model of Chronic Kidney Disease

J. Millán, C. Farquharson, L. Millán, 2021 .

Inhibition of tissue‐nonspecific alkaline phosphatase protects against medial arterial calcification and improves survival probability in the CKD‐MBD mouse model

J. Millán, A. Shimizu, S. Tsuruoka, 2020, The Journal of pathology.

Pathophysiological Role of Vascular Smooth Muscle Alkaline Phosphatase in Medial Artery Calcification

J. Millán, E. Sergienko, W. C. O'Neill, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Cloning and expression of the bovine intestinal alkaline phosphatase gene: biochemical characterization of the recombinant enzyme.

H. Weissig, J. Millán, M. Hoylaerts, 1993, The Biochemical journal.

Overexpression of tissue-nonspecific alkaline phosphatase (TNAP) in endothelial cells accelerates coronary artery disease in a mouse model of familial hypercholesterolemia

J. Millán, K. Margulies, A. Gerdes, 2017, PloS one.

Transgenic Overexpression of Tissue‐Nonspecific Alkaline Phosphatase (TNAP) in Vascular Endothelium Results in Generalized Arterial Calcification

J. Millán, Ilian A Radichev, A. Savinov, 2015, Journal of the American Heart Association.

The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells

J. Millán, C. Farquharson, V. Macrae, 2011, PloS one.

The functional role of soluble proteins acquired by extracellular vesicles

P. Ciancaglini, J. Millán, N. Rosato, 2022, Journal of extracellular biology.

DECREASED EXPRESSION OF COLD-INDUCIBLE RNA-BINDING PROTEIN (CIRP) IN MALE GERM CELLS AT ELEVATED TEMPERATURE

J. Millán, O. Yoshida, M. Fukumoto, 1999 .

Inhibition of vascular smooth muscle cell calcification by ATP analogues

J. Millán, V. Macrae, T. Arnett, 2019, Purinergic Signalling.

Inhibition of arterial medial calcification and bone mineralization by extracellular nucleotides: The same functional effect mediated by different cellular mechanisms

J. Millán, V. Macrae, T. Arnett, 2018, Journal of cellular physiology.

Tissue-Nonspecific Alkaline Phosphatase Acts Redundantly with PAP and NT5E to Generate Adenosine in the Dorsal Spinal Cord

R. Wightman, J. Millán, M. Zylka, 2013, The Journal of Neuroscience.

Mammalian glycophosphatidylinositol anchor transfer to proteins and posttransfer deacylation.

J. Millán, S. Udenfriend, G. Parker, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Increased calcium uptake and improved trabecular bone properties in intestinal alkaline phosphatase knockout mice

A. Rigalli, J. Millán, L. R. Brun, 2018, Journal of Bone and Mineral Metabolism.

Monoclonal Antibodies against Tissue-Nonspecific Alkaline Phosphatase

L. Ärlestig, J. Millán, K. Nustad, 2002, Tumor Biology.

Placental and intestinal alkaline phosphatases are receptors for Aeromonas sobria hemolysin.

T. Hirayama, J. Moss, J. Millán, 2005, International journal of medical microbiology : IJMM.

In Vivo Overexpression of Tissue‐Nonspecific Alkaline Phosphatase Increases Skeletal Mineralization and Affects the Phosphorylation Status of Osteopontin

J. Millán, S. Narisawa, M. C. Yadav, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Identification of a selective inhibitor of murine intestinal alkaline phosphatase (ML260) by concurrent ultra-high throughput screening against human and mouse isozymes.

T. Chung, Brock T Brown, M. Hedrick, 2014, Bioorganic & medicinal chemistry letters.

Intestinal alkaline phosphatase has beneficial effects in mouse models of chronic colitis

S. Snapper, J. Millán, K. Kaliannan, 2010, Inflammatory bowel diseases.

Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy

A. Pitsillides, J. Millán, C. Farquharson, 2021, bioRxiv.

Genetic variants of placental alkaline phosphatase as detected by a monoclonal antibody

J. Millán, G. Beckman, T. Stigbrand, 2004, Human Genetics.

Mammalian Alkaline Phosphatases: From Biology to Applications in Medicine and Biotechnology

J. Millán, 2006 .

Mammalian Alkaline Phosphatases Are Allosteric Enzymes*

J. Millán, T. Manes, M. Hoylaerts, 1997, The Journal of Biological Chemistry.

Intestinal Alkaline Phosphatase Deficiency Leads to Lipopolysaccharide Desensitization and Faster Weight Gain

J. Millán, J. Mecsas, K. Guillemin, 2014, Infection and Immunity.

Gene Therapy Using Adeno‐Associated Virus Serotype 8 Encoding TNAP‐D10 Improves the Skeletal and Dentoalveolar Phenotypes in Alpl −/− Mice

J. Millán, K. Miyake, B. Foster, 2021, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Molecular cloning and sequence analysis of human placental alkaline phosphatase.

J. Millán, 1986, The Journal of biological chemistry.

CAT constructs with convenient sites for cloning and generating deletions.

J. Millán, T. Manes, P. Tsonis, 1988, Nucleic Acids Research.

Systemic inhibition of tissue-nonspecific alkaline phosphatase alters the brain-immune axis in experimental sepsis

W. Geldenhuys, J. Millán, S. Benkovic, 2019, Scientific Reports.

Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation

T. Diekwisch, J. Millán, C. Farquharson, 2017, Front. Physiol..

The effect of cholesterol on the reconstitution of alkaline phosphatase into liposomes.

P. Ciancaglini, J. Millán, A. M. Simão, 2010, Biophysical chemistry.

Two alkaline phosphatase genes are expressed during early development in the mouse embryo.

D. Rappolee, R. Pedersen, Z. Werb, 1990, Development.

CHAPTER 9 – Alkaline Phosphatases

J. Millán, 2006 .

Conserved Epitopes in Human and Mouse Tissue-Nonspecific Alkaline Phosphatase

J. Millán, D. Harmey, S. Narisawa, 2005, Tumor Biology.

Novel Inhibitors of Alkaline Phosphatase Suppress Vascular Smooth Muscle Cell Calcification

J. Millán, W. C. O'Neill, M. Hoylaerts, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Phosphate Groups in the Lipid A Moiety Determine the Effects of LPS on Hepatic Stellate Cells: A Role for LPS-Dephosphorylating Activity in Liver Fibrosis

D. Schuppan, J. Millán, R. Hodin, 2020, Cells.

Enzyme Replacement Therapy for Murine Hypophosphatasia

R. Terkeltaub, M. McKee, J. Millán, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Kinetic Characterization of Hypophosphatasia Mutations With Physiological Substrates

J. Millán, A. Kozlenkov, T. Manes, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Inhibition of alkaline phosphatase impairs dyslipidemia and protects mice from atherosclerosis.

C. Fonta, J. Millán, K. Zibara, 2022, Translational research : the journal of laboratory and clinical medicine.

Embryonic alkaline phosphatase is expressed at M-phase in the spermatogenic lineage of the mouse.

J. Millán, S. Narisawa, M. Hofmann, 1992, Development.

Epitopes of human testis-specific lactate dehydrogenase deduced from a cDNA sequence.

J. Millán, E. Goldberg, K. Levan, 1987, Proceedings of the National Academy of Sciences of the United States of America.

Alkaline phosphatases contribute to uterine receptivity, implantation, decidualization, and defense against bacterial endotoxin in hamsters.

W. Lei, J. Millán, B. Paria, 2013, Reproduction.

Osteoblast tissue-nonspecific alkaline phosphatase antagonizes and regulates PC-1.

R. Terkeltaub, J. Millán, J. Goding, 2000, American journal of physiology. Regulatory, integrative and comparative physiology.

A Role for Intestinal Alkaline Phosphatase in the Maintenance of Local Gut Immunity

J. Millán, E. Hohmann, H. S. Warren, 2010, Digestive Diseases and Sciences.

The critical role of membralin in postnatal motor neuron survival and disease

S. Lipton, N. Nakanishi, J. Millán, 2015, eLife.

Treatment with bone maturation and average lifespan of HPP model mice by AAV8-mediated neonatal gene therapy via single muscle injection

J. Millán, N. Miyake, T. Shimada, 2021, Molecular therapy. Methods & clinical development.

Heterogeneity in alkaline phosphatase isozyme expression in human testicular germ cell tumours: An enzyme‐/immunohistochemical and molecular analysis

L. Looijenga, J. Millán, T. Manes, 1999, The Journal of pathology.

Establishment of Meiotic Germ-Cell Lines and Their Use to Study Spermatogenesis In Vitro

H. Weissig, J. Millán, M. Hofmann, 1996 .

Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice

J. Millán, C. Farquharson, E. Milne, 2012, PloS one.

Pharmacological TNAP inhibition efficiently inhibits arterial media calcification in a warfarin rat model but deserves careful consideration of potential physiological bone formation/mineralization impairment.

J. Millán, A. Pinkerton, E. Neven, 2020, Bone.

Intestinal alkaline phosphatase inhibits the proinflammatory nucleotide uridine diphosphate.

J. Millán, K. Kaliannan, E. Hohmann, 2013, American journal of physiology. Gastrointestinal and liver physiology.

Intestinal alkaline phosphatase inhibits the proinflammatory

J. Millán, K. Kaliannan, E. Hohmann, 2013 .

Lipid composition modulates ATP hydrolysis and calcium phosphate mineral propagation by TNAP-harboring proteoliposomes.

P. Ciancaglini, J. Millán, N. Rosato, 2020, Archives of biochemistry and biophysics.

Biology of Human Alkaline Phosphatases with Special to Cancer Reference

W. Fishman, J. Millán, 1995 .

Inhibition of PHOSPHO1 activity results in impaired skeletal mineralization during limb development of the chick.

J. Millán, C. Farquharson, L. McTeir, 2010, Bone.

Comparison of mouse and human keratin 18: a component of intermediate filaments expressed prior to implantation.

J. Millán, R. Oshima, G. Ceceña, 1986, Differentiation; research in biological diversity.

Interactions between CD36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet.

E. Widmaier, J. Millán, S. Narisawa, 2011, American journal of physiology. Regulatory, integrative and comparative physiology.

Interactions between CD 36 and global intestinal alkaline phosphatase in mouse small intestine and effects of high-fat diet

E. Widmaier, J. Millán, S. Narisawa, 2011 .

A novel phosphatase upregulated in Akp3 knockout mice.

J. Millán, K. Doctor, M. Hoylaerts, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Disruption of the murine intestinal alkaline phosphatase gene Akp3 impairs lipid transcytosis and induces visceral fat accumulation and hepatic steatosis.

J. Millán, Kayoko Tanaka, D. Alpers, 2007, American journal of physiology. Gastrointestinal and liver physiology.

Accelerated Fat Absorption in Intestinal Alkaline Phosphatase Knockout Mice

J. Millán, D. Alpers, S. Narisawa, 2003, Molecular and Cellular Biology.

Effects of disruption of the embryonic alkaline phosphatase gene on preimplantation development of the mouse

J. Millán, H. Dehghani, S. Narisawa, 2000, Developmental dynamics : an official publication of the American Association of Anatomists.

Oncodevelopmental alkaline phosphatases: in search for a function.

J. Millán, 1990, Progress in clinical and biological research.

Seminoma-derived Nagao isozyme is encoded by a germ-cell alkaline phosphatase gene.

J. Millán, T. Manes, 1988, Proceedings of the National Academy of Sciences of the United States of America.

Lipid microenvironment affects the ability of proteoliposomes harboring TNAP to induce mineralization without nucleators

P. Ciancaglini, J. Millán, M. Bottini, 2018, Journal of Bone and Mineral Metabolism.

Thermodynamic properties and characterization of proteoliposomes rich in microdomains carrying alkaline phosphatase.

P. Ciancaglini, J. Millán, A. M. Simão, 2011, Biophysical chemistry.

Correction: Altered Bone Development and an Increase in FGF-23 Expression in Enpp1−/− Mice

J. Millán, C. Farquharson, E. Milne, 2012, PLoS ONE.

Intestinal alkaline phosphatase prevents metabolic syndrome in mice

J. Millán, K. Kaliannan, E. Hohmann, 2013, Proceedings of the National Academy of Sciences.

A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis

J. Millán, Takaaki Shimohata, K. Miyamoto, 2018, Kidney and Blood Pressure Research.

Intestinal alkaline phosphatase promotes gut bacterial growth by reducing the concentration of luminal nucleotide triphosphates.

J. Millán, S. Robson, E. Hohmann, 2014, American journal of physiology. Gastrointestinal and liver physiology.

Three novel spermatogenesis‐specific zinc finger genes

H. Weissig, J. Millán, J. McCarrey, 2003, FEBS letters.

An active site mutant of human placental alkaline phosphatase with deficient enzymatic activity and preserved immunoreactivity.

J. Sowadski, J. Millán, S. Narisawa, 1990, Clinica chimica acta; international journal of clinical chemistry.

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing

J. Millán, C. Farquharson, P. Salmon, 2015, Bone.

Kinetic Analysis of Substrate Utilization by Native and TNAP-, NPP1-, or PHOSPHO1-Deficient Matrix Vesicles

P. Ciancaglini, J. Millán, C. Farquharson, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Functional Involvement of PHOSPHO1 in Matrix Vesicle–Mediated Skeletal Mineralization

J. Millán, C. Farquharson, D. Harmey, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Reference point indentation is not indicative of whole mouse bone measures of stress intensity fracture toughness

Jan L. Bruse, J. Millán, C. Farquharson, 2014, Bone.

Ablation of Osteopontin Improves the Skeletal Phenotype of Phospho1−/− Mice

J. Millán, C. Farquharson, M. Hoylaerts, 2014, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Homoarginine Supplementation Prevents Left Ventricular Dilatation and Preserves Systolic Function in a Model of Coronary Artery Disease

S. Bornstein, J. Millán, S. Bode-Böger, 2019, Journal of the American Heart Association.

The Role of Cytochrome c in Apoptosis: Increased Sensitivity to TNF-α is Associated with Respiratory Defects But Not with Lack of Cytochrome c Release.

J. Millán, L. Boise, C. Moraes, 2007 .

Testis-Specific Cytochrome c-Null Mice Produce Functional Sperm but Undergo Early Testicular Atrophy

John Calvin Reed, J. Millán, N. Hecht, 2002, Molecular and Cellular Biology.

Alkaline Phosphatase Knock‐Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

J. Millán, R. Weinstein, S. Coburn, 1999, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Establishment of mammalian testicular cell lines.

J. Millán, M. Hofmann, 1998, Methods in cell biology.

Allelic amino acid substitutions affect the conformation and immunoreactivity of germ-cell alkaline phosphatase phenotypes.

J. Millán, T. Manes, M. Hoylaerts, 1992, Clinical chemistry.

Site-directed mutagenesis and epitope-mapped monoclonal antibodies define a catalytically important conformational difference between human placental and germ cell alkaline phosphatase.

J. Millán, M. Hoylaerts, 1991, European journal of biochemistry.

Mineralization Profile of Annexin A6-Harbouring Proteoliposomes: Shedding Light on the Role of Annexin A6 on Matrix Vesicle-Mediated Mineralization

P. Ciancaglini, J. Millán, M. Bottini, 2022, International journal of molecular sciences.

Dual Role of the Trps1 Transcription Factor in Dentin Mineralization*

J. Millán, Brendan H. Lee, M. Bottini, 2014, The Journal of Biological Chemistry.

Locus determining the human sperm-specific lactate dehydrogenase, LDHC, is syntenic with LDHA.

S. Povey, J. Millán, Y. Edwards, 1987, Developmental genetics.

Hypophosphatasia - pathophysiology and treatment.

H. Plotkin, J. Millán, 2012, Actualizaciones en osteologia.

NPP1 and TNAP hydrolyze ATP synergistically during biomineralization.

P. Ciancaglini, J. Millán, M. Bottini, 2022, Purinergic signalling.

Ultrasensitive Diamond Microelectrode Application in the Detection of Ca2+ Transport by AnnexinA5-Containing Nanostructured Liposomes

P. Ciancaglini, A. Pasquarelli, J. Millán, 2022, Biosensors.

Phosphatidylserine-enriched monolayers controls calcium phosphate nucleation and growth: a physicochemical understanding of matrix vesicles mineralization

J. Millán, R. Buchet, S. Mebarek, 2021 .

Matrix vesicle biomimetics harboring Annexin A5 and alkaline phosphatase bind to the native collagen matrix produced by mineralizing vascular smooth muscle cells.

P. Ciancaglini, J. Millán, M. Hoylaerts, 2020, Biochimica et biophysica acta. General subjects.

Proteoliposomes with the ability to transport Ca(2+) into the vesicles and hydrolyze phosphosubstrates on their surface.

P. Ciancaglini, J. Millán, M. Hoylaerts, 2015, Archives of biochemistry and biophysics.

Effects of GPI-anchored TNAP on the dynamic structure of model membranes.

P. Ciancaglini, J. Millán, A. Costa-Filho, 2015, Physical chemistry chemical physics : PCCP.

Effects of pH on the Production of Phosphate and Pyrophosphate by Matrix Vesicles’ Biomimetics

P. Ciancaglini, J. Millán, M. Hoylaerts, 2013, Calcified Tissue International.

Proteoliposomes Harboring Alkaline Phosphatase and Nucleotide Pyrophosphatase as Matrix Vesicle Biomimetics

P. Ciancaglini, J. Millán, M. Hoylaerts, 2010, The Journal of Biological Chemistry.

Inorganic pyrophosphatase induces type I collagen in osteoblasts.

R. Terkeltaub, J. Millán, Kristen A. Johnson, 2010, Bone.

Arterial calcification in bone mineralization deficient mice

J. Millán, A. Lundquist, 2006 .

Cutaneous metabolism of vitamin B-6.

J. Millán, S. Coburn, A. Slominski, 2003, The Journal of investigative dermatology.

Knockout Mouse Models

J. Millán, 2006 .

Can insights into urodele limb regeneration be achieved with cell cultures and retroviruses?

J. Burns, J. Millán, P. Tsonis, 1996, The International journal of developmental biology.

Biology of human alkaline phosphatases with special reference to cancer.

W. Fishman, J. Millán, 1995, Critical reviews in clinical laboratory sciences.

Fluorescence evidence of annexin A6 translocation across membrane in model matrix vesicles during apatite formation

P. Ciancaglini, J. Millán, M. Bottini, 2022, Journal of Extracellular Biology.

Bispecific antibody-mediated lysis of placental and germ cell alkaline phosphatase targeted solid tumors in immunocompetent mice.

J. Millán, M. Hoylaerts, K. Smans, 1995, Cancer research.

Table 1, SAR results generated using analogue-by-catalogue (ABC)

Layton H. Smith, Thomas D.Y. Chung, Eduard Sergienko, 2010 .

Ectopic calcification in pseudoxanthoma elasticum responds to inhibition of tissue-nonspecific alkaline phosphatase

E. Chew, H. Dietz, W. Gahl, 2017, Science Translational Medicine.

Impaired calcification around matrix vesicles of growth plate and bone in alkaline phosphatase-deficient mice.

H. Anderson, J. Millán, N. Camacho, 2004, The American journal of pathology.

Dose response of bone-targeted enzyme replacement for murine hypophosphatasia.

J. Millán, R. Sah, M. Whyte, 2011, Bone.

Inactivation of two mouse alkaline phosphatase genes and establishment of a model of infantile hypophosphatasia

J. Millán, S. Narisawa, N. Fröhlander, 1997, Developmental dynamics : an official publication of the American Association of Anatomists.

Perspective on Dentoalveolar Manifestations Resulting From PHOSPHO1 Loss-of-Function: A Form of Pseudohypophosphatasia?

J. Millán, C. Farquharson, B. Foster, 2022, Frontiers in Dental Medicine.

Prevention of Lethal Murine Hypophosphatasia by Neonatal Ex Vivo Gene Therapy Using Lentivirally Transduced Bone Marrow Cells.

J. Millán, N. Miyake, T. Shimada, 2015, Human gene therapy.

PHOSPHO1 is essential for normal bone fracture healing

J. Millán, C. Farquharson, J. Li, 2018, Bone & joint research.

Extracellular matrix mineralization in periodontal tissues: Noncollagenous matrix proteins, enzymes, and relationship to hypophosphatasia and X-linked hypophosphatemia.

M. McKee, J. Millán, C. Chaussain, 2013, Periodontology 2000.

Central Role of Pyrophosphate in Acellular Cementum Formation

J. Millán, M. Somerman, B. Foster, 2012, PloS one.

Contribution of matrix vesicles and alkaline phosphatase to ectopic bone formation.

P. Ciancaglini, J. Millán, F. L. Camolezi, 2006, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Mammalian alkaline phosphatase catalysis requires active site structure stabilization via the N-terminal amino acid microenvironment.

J. Millán, M. Hoylaerts, S. Narisawa, 2006, Biochemistry.

Functional Characterization of Osteoblasts and Osteoclasts from Alkaline Phosphatase Knockout Mice

J. Millán, U. Lerner, S. Narisawa, 2000, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Genomic structure and comparison of mouse tissue-specific alkaline phosphatase genes.

J. Millán, T. Manes, C. Ziomek, 1990, Genomics.

Enzyme replacement prevents enamel defects in hypophosphatasia mice

J. Millán, R. Sah, M. Somerman, 2012, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Counter-regulatory phosphatases TNAP and NPP1 temporally regulate tooth root cementogenesis

J. Millán, M. Somerman, B. Foster, 2014, International Journal of Oral Science.

Neurodevelopmental alterations and seizures developed by mouse model of infantile hypophosphatasia are associated with purinergic signalling deregulation

Álvaro Sebastián‐Serrano, J. Millán, D. Henshall, 2016, Human molecular genetics.

Ablation of TNAP function compromises myelination and synaptogenesis in the mouse brain

László Négyessy, C. Fonta, J. Millán, 2012, Cell and Tissue Research.

Design and synthesis of selective inhibitors of placental alkaline phosphatase.

T. Chung, J. Cashman, J. Millán, 2010, Bioorganic & medicinal chemistry.

Gly429 is the major determinant of uncompetitive inhibition of human germ cell alkaline phosphatase by L-leucine.

J. Millán, C. Hummer, 1991, The Biochemical journal.

Investigation of quinoline-4-carboxylic acid as a highly potent scaffold for the development of alkaline phosphatase inhibitors: synthesis, SAR analysis and molecular modelling studies

J. Millán, J. Sévigny, J. Lecka, 2015 .

Design and synthesis of pyrazole derivatives as potent and selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Brock T Brown, J. Millán, E. Sergienko, 2009, Bioorganic & medicinal chemistry letters.

Characterization and use of an allotype-specific monoclonal antibody to placental alkaline phosphatase in the study of cancer-related phosphatase polymorphism.

W. Fishman, E. Ruoslahti, J. Millán, 1982, Cancer research.

Extracellular pyrophosphate metabolism and calcification in

G. Dubyak, J. Millán, Xiaonan H. Wang, 2011 .

Cholesterol regulates the incorporation and catalytic activity of tissue-nonspecific alkaline phosphatase in DPPC monolayers.

P. Ciancaglini, J. Millán, M. Bottini, 2019, Langmuir : the ACS journal of surfaces and colloids.

Is alkaline phosphatase biomimeticaly immobilized on titanium able to propagate the biomineralization process?

P. Ciancaglini, J. Millán, A. Ramos, 2019, Archives of biochemistry and biophysics.

Severe skeletal toxicity from protracted etidronate therapy for generalized arterial calcification of infancy

J. Millán, W. Mcalister, S. Mumm, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Polyphosphates inhibit extracellular matrix mineralization in MC3T3-E1 osteoblast cultures.

M. McKee, J. Millán, B. Hoac, 2013, Bone.

An Investigation of the Mineral in Ductile and Brittle Cortical Mouse Bone

A. Boyde, E. Saiz, J. Millán, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Functional Significance of Calcium Binding to Tissue-Nonspecific Alkaline Phosphatase

J. Millán, M. Hoylaerts, S. Narisawa, 2015, PloS one.

cDNA sequences from the alpha subunit of the fibronectin receptor predict a transmembrane domain and a short cytoplasmic peptide.

E. Ruoslahti, J. Millán, M. Pierschbacher, 1986, The Journal of biological chemistry.

Residues Determining the Binding Specificity of Uncompetitive Inhibitors to Tissue‐Nonspecific Alkaline Phosphatase

J. Millán, A. Kozlenkov, P. Cuniasse, 2004, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: an integrated model of the pathogenesis of mineralization disorders.

R. Terkeltaub, J. Millán, D. Harmey, 2004, The American journal of pathology.

PHOSPHO1 is essential for mechanically competent mineralization and the avoidance of spontaneous fractures.

Simon R. Goodyear, R. Aspden, J. Millán, 2010, Bone.

How To Build a Bone: PHOSPHO1, Biomineralization, and Beyond

J. Millán, C. Farquharson, K. Staines, 2019, JBMR plus.

Comparative analysis of cell surface antigens expressed by cell lines derived from human germ cell tumours

P. Stern, P. Andrews, L. Looijenga, 1996, International journal of cancer.

Genetic Complexity, Structure, and Characterization of Highly Active Bovine Intestinal Alkaline Phosphatases*

J. Millán, F. Lottspeich, T. Manes, 1998, The Journal of Biological Chemistry.

Acidosis Is a key regulator of osteoblast ecto‐nucleotidase pyrophosphatase/phosphodiesterase 1 (NPP1) expression and activity

J. Millán, T. Arnett, I. Orriss, 2015, Journal of cellular physiology.

Loss of Skeletal Mineralization by the Simultaneous Ablation of PHOSPHO1 and Alkaline Phosphatase Function: A Unified Model of the Mechanisms of Initiation of Skeletal Calcification

M. McKee, J. Millán, C. Farquharson, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Glycosylation differences contribute to distinct catalytic properties among bone alkaline phosphatase isoforms.

J. Millán, S. Narisawa, P. Magnusson, 2009, Bone.

Structure, substrate specificity and functional relatedness to other members of a large superfamily of enzymes

J. Millán, 2006 .

A robust transcriptional program in newts undergoing multiple events of lens regeneration throughout their lifespan

J. Millán, Konstantinos Sousounis, P. Tsonis, 2015, eLife.

Phenotypes of placental‐type alkaline phosphatase in seminoma sera as defined by monoclonal antibodies

J. Millán, P. Esposti, B. Wahrén, 1986, International journal of cancer.

Germ Cell Survival Through Carbohydrate-Mediated Interaction with Sertoli Cells

D. A. O’Brien, J. Millán, C. Ohyama, 2002, Science.

A possible new locus of alkaline phosphatase expressed in human testis

J. Millán, T. Stigbrand, A. Eriksson, 2004, Human Genetics.

Tumour and cellular localization by use of monoclonal and polyclonal antibodies to placental alkaline phosphatase.

J. Millán, B. Wahrén, T. Stigbrand, 1984, British Journal of Cancer.

Antigenic determinants of human placental and testicular placental-like alkaline phosphatases as mapped by monoclonal antibodies.

J. Millán, T. Stigbrand, Torgny Stigbrand, 1983, European journal of biochemistry.

Placental alkaline phosphatase as a tumor marker for seminoma.

W. Fishman, R. Vessella, P. Lange, 1982, Cancer research.

"Sandwich" enzyme immunoassay for placental alkaline phosphatase.

J. Millán, T. Stigbrand, 1981, Clinical chemistry.

Structural Evidence of Functional Divergence in Human Alkaline Phosphatases*

J. Millán, M. Le Du, 2002, The Journal of Biological Chemistry.

Alkaline phosphatase as a reporter of cancerous transformation.

J. Millán, 1992, Clinica chimica acta; international journal of clinical chemistry.

DNA polymorphism of alkaline phosphatase isozyme genes: linkage disequilibria between placental and germ-cell alkaline phosphatase alleles.

J. Millán, G. Beckman, L. Beckman, 1992, American journal of human genetics.

Structural comparisons of two allelic variants of human placental alkaline phosphatase.

H. Jörnvall, J. Millán, T. Stigbrand, 1985, International Journal of Biochemistry.

Highly sensitive solid-phase immunoenzymometric assay for placental and placental-like alkaline phosphatases with a monoclonal antibody and monodisperse polymer particles.

B. No̸rgaard-Pedersen, J. Millán, K. Nustad, 1985, Clinical chemistry.

The genetic basis of alkaline phosphatase isozyme expression.

W. Fishman, J. Millán, T. Stigbrand, 1982, Isozymes.

Structure, genomic DNA typing, and kinetic characterization of the D allozyme of placental alkaline phosphatase (PLAP/ALPP)

J. Millán, A. Kozlenkov, L. Beckman, 2002, Human mutation.

Isozyme profile and tissue-origin of alkaline phosphatases in mouse serum.

J. Millán, S. Narisawa, P. Magnusson, 2013, Bone.

Isozyme profileandtissue-origin ofalkaline phosphatases in mouseserum

J. Millán, S. Narisawa, P. Magnusson, 2013 .

Differences between the Placental and the Testicular Placental-Like Alkaline Phosphatase as Detected by Monoclonal Antibodies

J. Millán, T. Stigbrand, A. Jeppsson, 1984 .

A hidden antigenic determinant on membrane-bound human placental alkaline phosphatase.

W. Fishman, J. Millán, R. Jemmerson, 1987, Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine.

Monoclonal antibodies block the bromelain‐mediated release of human placental alkaline phosphatase from cultured cancer cells

W. Fishman, J. Millán, R. Jemmerson, 1985, FEBS letters.

The mechanism of placental alkaline phosphatase induction in vitro

T. Fukasawa, J. Millán, K. Hirano, 1989, Cell biochemistry and function.

Evidence for the expression of a primitive intestinal-like alkaline phosphatase in the intestinal 407 cell line.

J. Millán, K. Hirano, T. Stigbrand, 1988, Biochemical and biophysical research communications.

Developmental expression of alkaline phosphatase genes; reexpression in germ cell tumours and in vitro immortalized germ cells.

J. Millán, M. Hofmann, 1993, European urology.

Modifications in a flexible surface loop modulate the isozyme-specific properties of mammalian alkaline phosphatases.

J. Millán, M. Hoylaerts, M. Bossi, 1993, The Journal of biological chemistry.

Evaluation of a new, sensitive radioimmunoassay for placental alkaline phosphatase in pre- and post-operative sera from the Danish testicular cancer material.

B. No̸rgaard-Pedersen, J. Millán, K. Nustad, 1984, Progress in clinical and biological research.

What Can We Learn About the Neural Functions of TNAP from Studies on Other Organs and Tissues?

J. Millán, 2015, Sub-cellular biochemistry.

Stage‐specific expression of alkaline phosphatase during neural development in the mouse

J. Millán, Keiichi Watanabe, S. Narisawa, 1994, Developmental dynamics : an official publication of the American Association of Anatomists.

Intestinal alkaline phosphatase is a gut mucosal defense factor maintained by enteral nutrition

Kyle R. Eberlin, J. Millán, H. S. Warren, 2008, Proceedings of the National Academy of Sciences.

Promoter structure of the human intestinal alkaline phosphatase gene.

J. Millán, 1987, Nucleic acids research.

Effect of tissue non‐specific alkaline phosphatase in maintenance of structure of murine colon and stomach

R. Schmidt, J. Millán, M. Engle, 2000, Microscopy research and technique.

Tissue-nonspecific alkaline phosphatase is an anti-inflammatory nucleotidase.

C. Fonta, J. Millán, E. Matera, 2020, Bone.

Transgenic mice expressing the tumor marker germ cell alkaline phosphatase: an in vivo tumor model for human cancer antigens.

J. Millán, M. Hoylaerts, K. Smans, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Structural studies of human placental alkaline phosphatase in complex with functional ligands.

J. Millán, A. Ménez, E. Stura, 2005, Journal of molecular biology.

A putative functional domain of human placental alkaline phosphatase predicted from sequence comparisons.

J. Millán, P. Tsonis, W. Argraves, 1988, The Biochemical journal.

Soluble Ecto-5′-nucleotidase (5′-NT), Alkaline Phosphatase, and Adenosine Deaminase (ADA1) Activities in Neonatal Blood Favor Elevated Extracellular Adenosine*

O. Levy, J. Millán, A. Usheva, 2013, The Journal of Biological Chemistry.

Matrix vesicles from chondrocytes and osteoblasts: Their biogenesis, properties, functions and biomimetic models.

P. Ciancaglini, N. Volkmann, D. Hanein, 2018, Biochimica et biophysica acta. General subjects.

Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease

Álvaro Sebastián‐Serrano, J. Ávila, J. Millán, 2014, Computational and structural biotechnology journal.

Catalytic Signature of a Heat-Stable, Chimeric Human Alkaline Phosphatase with Therapeutic Potential

P. Ciancaglini, J. Millán, M. Hoylaerts, 2014, PloS one.

Function Assignment to Conserved Residues in Mammalian Alkaline Phosphatases*

J. Millán, A. Kozlenkov, T. Manes, 2002, The Journal of Biological Chemistry.

Tissue‐nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures

H. Weissig, J. Millán, F. Binette, 1995, Developmental dynamics : an official publication of the American Association of Anatomists.

Molecular mechanism of uncompetitive inhibition of human placental and germ-cell alkaline phosphatase.

J. Millán, T. Manes, M. Hoylaerts, 1992, The Biochemical journal.

Assay Format as a Critical Success Factor for Identification of Novel Inhibitor Chemotypes of Tissue-Nonspecific Alkaline Phosphatase from High-Throughput Screening

T. Chung, J. Millán, E. Sergienko, 2010, Molecules.

PstI restriction fragment length polymorphism of the human intestinal alkaline phosphatase gene.

J. Millán, G. Beckman, L. Beckman, 1994, Human heredity.

A new PstI restriction fragment length polymorphism (RFLP) of placental alkaline phosphatase. RFLP haplotypes and correlation with electrophoretic types.

J. Millán, G. Beckman, L. Beckman, 1991, Human heredity.

Correlation between RsaI restriction fragment length polymorphism and electrophoretic types of human placental alkaline phosphatase.

J. Millán, G. Beckman, L. Beckman, 1989, Human heredity.

Mitochondrial TNAP controls thermogenesis by hydrolysis of phosphocreatine

B. Spiegelman, Mark P. Jedrychowski, J. Millán, 2021, Nature.

Enzyme-replacement therapy in life-threatening hypophosphatasia.

Nick Bishop, José Luis Millán, Matthew Downs, 2012, The New England journal of medicine.

Elevated Skeletal Osteopontin Levels Contribute to the Hypophosphatasia Phenotype in Akp2−/− Mice

R. Terkeltaub, J. Millán, N. Camacho, 2006, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Sustained osteomalacia of long bones despite major improvement in other hypophosphatasia-related mineral deficits in tissue nonspecific alkaline phosphatase/nucleotide pyrophosphatase phosphodiesterase 1 double-deficient mice.

R. Terkeltaub, H. Anderson, J. Millán, 2005, The American journal of pathology.

Inhibition of Tissue-Nonspecific Alkaline Phosphatase Attenuates Ectopic Mineralization in the Abcc6-/- Mouse Model of PXE but Not in the Enpp1 Mutant Mouse Models of GACI.

J. Sundberg, J. Uitto, J. Millán, 2019, The Journal of investigative dermatology.

Discovery of 5-((5-chloro-2-methoxyphenyl)sulfonamido)nicotinamide (SBI-425), a potent and orally bioavailable tissue-nonspecific alkaline phosphatase (TNAP) inhibitor.

M. Jackson, J. Millán, E. Sergienko, 2018, Bioorganic & medicinal chemistry letters.

Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP).

Brock T Brown, J. Millán, E. Sergienko, 2009, Journal of medicinal chemistry.

Identification and Characterization of Novel Tissue-Nonspecific Alkaline Phosphatase Inhibitors with Diverse Modes of Action

X. Chan, Brock T Brown, J. Millán, 2009, Journal of biomolecular screening.

The Role of Phosphatases in the Initiation of Skeletal Mineralization

J. Millán, 2012, Calcified Tissue International.

Exonic splicing signals impose constraints upon the evolution of enzymatic activity

K. Vlahovicek, J. Millán, M. Baralle, 2014, Nucleic acids research.

Hypophosphatasia (adult form): quantitation of serum alkaline phosphatase isoenzyme activity in a large kindred.

W. Fishman, J. Millán, L. Avioli, 1980, Clinical chemistry.

Intestinal alkaline phosphatase preserves the normal homeostasis of gut microbiota

J. Millán, E. Hohmann, H. S. Warren, 2010, Gut.

A Novel Approach to Maintain Gut Mucosal Integrity Using an Oral Enzyme Supplement

J. Millán, K. Kaliannan, P. Fagenholz, 2014, Annals of surgery.

TNAP upregulation is a critical factor in Tauopathies and its blockade ameliorates neurotoxicity and increases life-expectancy

Álvaro Sebastián‐Serrano, J. Ávila, J. Millán, 2022, Neurobiology of Disease.

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

B. Stec, J. Millán, N. Cosford, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Sequence Motifs Specifying Homing and Metastasis to Bone

J. Millán, 1999 .

Localization of human tumor xenografts by 125I-labelled monoclonal and polyclonal antibodies to placental alkaline phosphatase.

J. Millán, B. Wahrén, T. Stigbrand, 1984, Progress in clinical and biological research.

Design, synthesis and evaluation of benzoisothiazolones as selective inhibitors of PHOSPHO1.

J. Millán, E. Sergienko, N. Cosford, 2014, Bioorganic & medicinal chemistry letters.

Bone‐Targeted Alkaline Phosphatase

J. Millán, 2013 .

Phosphatase Modulators

J. Millán, 2013, Methods in Molecular Biology.

High-throughput screening of tissue-nonspecific alkaline phosphatase for identification of effectors with diverse modes of action

J. Millán, E. Sergienko, 2010, Nature Protocols.

Shedding Light on the Role of Na,K-ATPase as a Phosphatase during Matrix-Vesicle-Mediated Mineralization

P. Ciancaglini, J. Millán, M. Fiore, 2022, International journal of molecular sciences.

Three-dimensional cell-laden collagen scaffolds: From biochemistry to bone bioengineering.

P. Ciancaglini, J. Millán, M. Bottini, 2021, Journal of biomedical materials research. Part B, Applied biomaterials.

Localization of Annexin A6 in Matrix Vesicles During Physiological Mineralization

P. Ciancaglini, J. Millán, N. Rosato, 2020, International journal of molecular sciences.

Biophysical aspects of biomineralization

P. Ciancaglini, J. Millán, M. Hoylaerts, 2017, Biophysical Reviews.

Placental Alkaline Phosphatase

J. Millán, S. Narisawa, 1992 .

Comparison of mouse and human keratin 18: A component of intermediate filaments expressed prior to implantation

J. Millán, R. Oshima, G. Ceceña, 1986 .

Oncodevelopmental expression and structure of alkaline phosphatase genes.

J. Millán, 1988, Anticancer research.

The Role of Phosphatases in the Initiation of Skeletal Mineralization

J. Millán, 2013, Calcified Tissue International.

Prolonged Survival and Phenotypic Correction of Akp2−/− Hypophosphatasia Mice by Lentiviral Gene Therapy

J. Millán, T. Shimada, T. Maeda, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Dental defects in the primary dentition associated with hypophosphatasia from biallelic ALPL mutations.

L. Suva, J. Millán, D. Gaddy, 2020, Bone.

Protein Structure and Functional Domains

J. Millán, 2006 .

Ethnic differences in enzyme and DNA polymorphisms of human tissue-specific alkaline phosphatases.

J. Millán, G. Beckman, C. Sikström, 1994, Human heredity.

Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro.

J. Millán, T. Dokland, E. Beniash, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Immortalized germ cells undergo meiosis in vitro.

J. Millán, M. Hofmann, R. Hess, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Refinement of the differentiated phenotype of the spermatogenic cell line GC-2spd(ts)

J. Millán, M. Hofmann, S. Coonrod, 1996, Biology of reproduction.

A HAPLOID AND A DIPLOID CELL CYCLE COEXIST IN AN IN VITRO IMMORTALIZED SPERMATOGENIC CELL LINE

J. Millán, M. Hofmann, D. Abramian, 1995 .

A haploid and a diploid cell coexist in an in vitro immortalized spermatogenic cell line.

J. Millán, M. Hofmann, D. Abramian, 1995, Developmental genetics.

Genomic structure and promoter activity of the human testis lactate dehydrogenase gene.

J. Millán, M. Hofmann, E. Goldberg, 1993, Biology of reproduction.

Abundance of repetitive sequence elements in the mouse testis-specific lactate dehydrogenase-C gene.

J. Millán, S. Narisawa, E. Goldberg, 2003, Journal of andrology.

Accelerated Aging and Clearance of Host Anti-inflammatory Enzymes by Discrete Pathogens Fuels Sepsis.

V. Nizet, J. Marth, J. Millán, 2018, Cell host & microbe.

Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor.

J. Millán, D. Lawrence, D. Loskutoff, 1986, Proceedings of the National Academy of Sciences of the United States of America.

VHY, a Novel Myristoylated Testis-restricted Dual Specificity Protein Phosphatase Related to VHX*

A. Alonso, T. Mustelin, H. Huynh, 2004, Journal of Biological Chemistry.

Alkaline phosphatases as reporters of developmental and cancerous events.

J. Millán, N. Fröhlander, 1991, In vivo.

Enzyme replacement for craniofacial skeletal defects and craniosynostosis in murine hypophosphatasia.

J. Millán, A. Caron, M. C. Yadav, 2015, Bone.

Hydrolysis of 2′3′-cGAMP by ENPP1 and design of non-hydrolyzable analogs

T. Mitchison, J. Millán, Lingyin Li, 2014, Nature chemical biology.

Gene Therapy Using Recombinant AAV Type 8 Vector Encoding TNAP‐D10 Improves the Skeletal Phenotypes in Murine Models of Osteomalacia

J. Millán, C. Farquharson, K. Miyake, 2022, JBMR plus.

Molecular characterisation of the Hyp deletion and an improved assay for its detection.

J. Millán, G. Pilarowski, C. Sheen, 2012, Bone.

Treatment of hypophosphatasia by muscle-directed expression of bone-targeted alkaline phosphatase via self-complementary AAV8 vector

J. Millán, N. Miyake, T. Shimada, 2016, Molecular therapy. Methods & clinical development.

Rescue of severe infantile hypophosphatasia mice by AAV-mediated sustained expression of soluble alkaline phosphatase.

J. Millán, N. Miyake, T. Shimada, 2011, Human gene therapy.

Molecular diagnosis of hypophosphatasia and differential diagnosis by targeted Next Generation Sequencing.

J. Millán, J. Roume, J. Salles, 2015, Molecular genetics and metabolism.

PHOSPHO 1 IS ESSENTIAL FOR NORMAL BONE FRACTURE HEALING

J. Millán, M. Murshed, R. Hamdy, 2016 .

Expression of N-cadherin and alkaline phosphatase in chick limb bud mesenchymal cells: regulation by 1,25-dihydroxyvitamin D3 or TGF-beta 1.

J. Millán, P. Tsonis, K. Del Rio-Tsonis, 1994, Experimental cell research.

Topographic analysis by atomic force microscopy of proteoliposomes matrix vesicle mimetics harboring TNAP and AnxA5.

P. Ciancaglini, J. Millán, L. Bagatolli, 2017, Biochimica et biophysica acta. Biomembranes.

Effect of the presence of cholesterol in the interfacial microenvironment on the modulation of the alkaline phosphatase activity during in vitro mineralization.

P. Ciancaglini, J. Millán, M. Hoylaerts, 2017, Colloids and surfaces. B, Biointerfaces.

Osteoconductivity and osteoinductivity of NanoFUSE® DBM

J. Millán, S. Narisawa, J. Kirk, 2013, Cell and Tissue Banking.

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

J. Millán, C. Farquharson, C. Lewis, 2018, Blood.

Corrigendum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

T. Mitchison, J. Millán, Lingyin Li, 2015, Nature chemical biology.

Mineralisation of collagen rich soft tissues and osteocyte lacunae in Enpp1−/− mice

A. Boyde, J. Millán, V. Macrae, 2014, Bone.

Proteoliposomes in nanobiotechnology

M. Colhone, P. Ciancaglini, J. Millán, 2012, Biophysical Reviews.

Pendant-drop method coupled to ultraviolet-visible spectroscopy: A useful tool to investigate interfacial phenomena.

P. Ciancaglini, J. Millán, A. Ramos, 2016, Colloids and surfaces. A, Physicochemical and engineering aspects.

PAR2 regulates regeneration, transdifferentiation, and death

J. Millán, F. Levine, E. Hao, 2016, Cell Death & Disease.

A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

J. Millán, C. Farquharson, V. Macrae, 2013, Molecular and Cellular Endocrinology.

Genetic and pharmacologic modulation of cementogenesis via pyrophosphate regulators.

J. Millán, D. Braddock, M. Somerman, 2020, Bone.

Weighing the Evidence for the Roles of Plasma Versus Local Pyrophosphate in Ectopic Calcification Disorders

J. Uitto, J. Millán, Qiaoli Li, 2023, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Chronic Kidney Disease-Induced Arterial Media Calcification in Rats Prevented by Tissue Non-Specific Alkaline Phosphatase Substrate Supplementation Rather Than Inhibition of the Enzyme

J. Millán, A. Pinkerton, E. Neven, 2021, Pharmaceutics.

Visualization of Mineral‐Targeted Alkaline Phosphatase Binding to Sites of Calcification In Vivo

J. Millán, M. Bottini, S. Narisawa, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Skeletal Mineralization Deficits and Impaired Biogenesis and Function of Chondrocyte‐Derived Matrix Vesicles in Phospho1–/– and Phospho1/Pit1 Double‐Knockout Mice

B. Fadeel, J. Millán, C. Farquharson, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Improvement of the skeletal and dental hypophosphatasia phenotype in Alpl-/- mice by administration of soluble (non-targeted) chimeric alkaline phosphatase.

J. Millán, M. Somerman, B. Foster, 2015, Bone.

Sex-dependent, zinc-induced dephosphorylation of phospholamban by tissue-nonspecific alkaline phosphatase in the cardiac sarcomere.

Y. Wang, B. Palmer, J. Millán, 2014, American journal of physiology. Heart and circulatory physiology.

A distinctive patchy osteomalacia characterises Phospho1‐deficient mice

A. Boyde, A. Pitsillides, J. Millán, 2017, Journal of anatomy.

A distinctive patchy osteomalacia characterises Phospho1‐deficient mice

A. Boyde, A. Pitsillides, J. Millán, 2017, Journal of Anatomy.

Increased PHOSPHO1 and alkaline phosphatase expression during the anabolic bone response to intermittent parathyroid hormone delivery

A. Pitsillides, J. Millán, C. Farquharson, 2022, Cell biochemistry and function.

Alkaline Phosphatase and Hypophosphatasia

J. Millán, M. Whyte, 2015, Calcified Tissue International.

Langmuir monolayers and proteoliposomes as models of matrix vesicles involved in biomineralization

P. Ciancaglini, J. Millán, M. Bottini, 2021, Biophysical Reviews.

Quantitative atomic force microscopy provides new insight into matrix vesicle mineralization.

S. Esener, P. Ciancaglini, J. Millán, 2019, Archives of biochemistry and biophysics.

Proteoliposomes in nanobiotechnology

M. Colhone, P. Ciancaglini, J. Millán, 2012, Biophysical Reviews.

Proteoliposomes as matrix vesicles' biomimetics to study the initiation of skeletal mineralization.

P. Ciancaglini, J. Millán, M. C. Yadav, 2010, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

Upregulation of IGF2 expression during vascular calcification.

J. Millán, C. Farquharson, Dongxing Zhu, 2014, Journal of molecular endocrinology.

Effects of etidronate on the Enpp1−/− mouse model of generalized arterial calcification of infancy

J. Millán, V. Macrae, K. Staines, 2015, International journal of molecular medicine.

Tissue-nonspecific Alkaline Phosphatase Blockade Ameliorates Behavioural Deficits and Life-expectancy on Tauopathies

Álvaro Sebastián‐Serrano, J. Ávila, J. Millán, 2020 .

Erratum: Hydrolysis of 2'3'-cGAMP by ENPP1 and design of nonhydrolyzable analogs.

T. Mitchison, J. Millán, Lingyin Li, 2015, Nature chemical biology.

TNAP In The Brain: Functions In Neurotransmission

L. Nowak, László Négyessy, C. Fonta, 2012 .

Hypomineralisation drives joint instability and osteoarthritis in mice

A. Pitsillides, J. Millán, C. Farquharson, 2016 .

The immortalized mouse germ cell lines GC-1spg and GC-2spd as a model for mitochondrial differentiation during meiosis.

J. Millán, G. Wennemuth, A. Meinhardt, 1997, Advances in experimental medicine and biology.

The Role of PHOSPHO1 in the Initiation of Skeletal Calcification

Nicholas Michael Hedrick, T. Chung, J. Rascon, 2010 .

Ablation of TNAP function compromises myelination and synaptogenesis in the mouse brain

László Négyessy, C. Fonta, J. Millán, 2012, Cell and Tissue Research.

Mechanical and biocompatible characterization of a cross-linked collagen-hyaluronic acid wound dressing

J. Millán, S. Narisawa, J. Kirk, 2013, Biomatter.

Conversion of secretory proteins into membrane proteins by fusing with a glycosylphosphatidylinositol anchor signal of alkaline phosphatase.

J. Millán, Y. Misumi, N. Takami, 1994, The Biochemical journal.

Effects of pH on the Production of Phosphate and Pyrophosphate by Matrix Vesicles’ Biomimetics

P. Ciancaglini, J. Millán, M. Hoylaerts, 2013, Calcified Tissue International.

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.

J. Millán, C. Farquharson, D. Harmey, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Evidence that pyrophosphate acts as an extracellular signalling molecule to exert direct functional effects in primary cultures of osteoblasts and osteoclasts.

J. Millán, T. Arnett, I. Orriss, 2023, Bone.

Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification.

J. Millán, W. C. O'Neill, S. Narisawa, 2008, Kidney international.

Prenatal enzyme replacement therapy for Akp2−/− mice with lethal hypophosphatasia

A. Okamoto, J. Millán, A. Umezawa, 2021, Regenerative therapy.

Intravesicular Phosphatase PHOSPHO1 Function in Enamel Mineralization and Prism Formation

J. Wingfield, T. Diekwisch, J. Pérez, 2017, Front. Physiol..

Enzyme Replacement Therapy Prevents Dental Defects in a Model of Hypophosphatasia

Jeffrey J. Gray, David L. Masica, J. J. Gray, 2011, Journal of dental research.

Tissue-nonspecific Alkaline Phosphatase Regulates Purinergic Transmission in the Central Nervous System During Development and Disease

J. Ávila, J. Millán, M. Miras-Portugal, 2014, Computational and structural biotechnology journal.

Tissue-nonspecific alkaline phosphatase participates in the establishment and growth of feather germs in embryonic chick skin cultures.

H. Weissig, J. Millán, F. Binette, 1995 .

Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization.

J. Millán, C. Farquharson, D. Harmey, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A protective role for FGF-23 in local defence against disrupted arterial wall integrity?

J. Millán, C. Farquharson, V. Macrae, 2013, Molecular and Cellular Endocrinology.

A Role of Intestinal Alkaline Phosphatase 3 (Akp3) in Inorganic Phosphate Homeostasis

J. Millán, K. Miyamoto, S. Narisawa, 2018, Kidney and Blood Pressure Research.

Enhanced phosphocholine metabolism is essential for terminal erythropoiesis.

J. Millán, C. Farquharson, C. Lewis, 2018, Blood.

Accelerated Fat Absorption in Intestinal Alkaline Phosphatase Knockout Mice

J. Millán, D. Alpers, S. Narisawa, 2003, Molecular and Cellular Biology.

The Appearance and Modulation of Osteocyte Marker Expression during Calcification of Vascular Smooth Muscle Cells

J. Millán, C. Farquharson, V. Macrae, 2011, PloS one.

A distinctive patchy osteomalacia characterises Phospho1‐deficient mice

A. Boyde, A. Pitsillides, J. Millán, 2017, Journal of anatomy.

PHOSPHO1 is essential for normal bone fracture healing

J. Millán, M. Murshed, R. Hamdy, 2016, Bone & joint research.

Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification

B. Stec, J. Millán, N. Cosford, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro.

J. Millán, T. Dokland, E. Beniash, 2016, Matrix biology : journal of the International Society for Matrix Biology.

Dentoalveolar Alterations in an Adenine‐Induced Chronic Kidney Disease Mouse Model

J. Millán, E. Chu, B. Foster, 2023, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

US 005707833 A 11 ) Patent Number : 5 , 707833 45 Date of Patent : Jan . 13 , 1998

J. Millán, 2017 .

Enzyme-replacement therapy in life-threatening hypophosphatasia.

J. Millán, N. Bishop, C. Greenberg, 2012, The New England journal of medicine.

Upregulation of alkaline phosphatase and pyrophosphate hydrolysis: potential mechanism for uremic vascular calcification.

J. Millán, S. Narisawa, K. Lomashvili, 2008, Kidney international.

Tissue-nonspecific alkaline phosphatase deficiency causes abnormal craniofacial bone development in the Alpl(-/-) mouse model of infantile hypophosphatasia.

J. Millán, N. Hatch, Jin Liu, 2014, Bone.

S1670 A Potential Role for Intestinal Alkaline Phosphatase in Colonic Inflammation

J. Millán, R. Hodin, A. Bhan, 2009 .