K. Gardiner

发表

Self-Organizing Feature Maps Identify Proteins Critical to Learning in a Mouse Model of Down Syndrome

K. Cios, C. Higuera, K. Gardiner, 2015, PloS one.

The DNA sequence of human chromosome 21

M. Hattori, T. Takagi, Y. Sakaki, 2000, Nature.

The RNA moiety of ribonuclease P is the catalytic subunit of the enzyme

N. Pace, T. Marsh, S. Altman, 1983, Cell.

Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis.

K. Gardiner, M. Davisson, D. Slavov, 2002, Genomics.

Pharmacological approaches to improving cognitive function in Down syndrome: current status and considerations

K. Gardiner, Katheleen J Gardiner, 2014, Drug design, development and therapy.

Mouse models of Down syndrome: gene content and consequences

A. Dhanasekaran, K. Gardiner, Meenal Gupta, 2016, Mammalian Genome.

The cognitive phenotype of Down syndrome: Insights from intracellular network analysis

R. Iyengar, Avi Ma’ayan, K. Gardiner, 2006, NeuroRX.

Human genome organization.

K. Gardiner, 1995, Current opinion in genetics & development.

The cognitive phenotype of Down syndrome: Insights from intracellular network analysis

R. Iyengar, Avi Ma’ayan, K. Gardiner, 2006 .

A validation method for fuzzy clustering of gene expression data

K. Gardiner, Thanh Le, 2011 .

Mouse models of Down syndrome: how useful can they be? Comparison of the gene content of human chromosome 21 with orthologous mouse genomic regions.

Katheleen Gardiner, K. Gardiner, M. Davisson, 2003, Gene.

Genomic sequence analysis tools: a user's guide.

K. Gardiner, A. Fortna, K Gardiner, 2001, Trends in genetics : TIG.

Gene expression relevant to Down syndrome: problems and approaches.

K. Gardiner, F. Tassone, D. Slavov, 1999, Journal of neural transmission. Supplementum.

RCDA: a highly sensitive and specific alternatively spliced transcript assembly tool featuring upstream consecutive exon structures.

K. Gardiner, Xiaolu Sturgeon, 2012, Genomics.

Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia.

U. Jäger, K. Gardiner, R. Wieser, 2000, Biochemical and biophysical research communications.

Down Syndrome: Genes, Model Systems, and Progress towards Pharmacotherapies and Clinical Trials for Cognitive Deficits

K. Gardiner, J. Busciglio, G. Capone, 2013, Cytogenetic and Genome Research.

Molecular genetic characterization and comparative mapping of the humanPCP4 gene

K. Gardiner, R. Reeves, D. Cabin, 1996, Somatic cell and molecular genetics.

Pulsed field gel electrophoresis and investigations into mammalian genome organization.

K. Gardiner, 1990, Journal of cell science.

The structure of the human interferon alpha/beta receptor gene.

G. Lutfalla, K. Gardiner, G. Uzé, 1992, The Journal of biological chemistry.

A new member of the cytokine receptor gene family maps on chromosome 21 at less than 35 kb from IFNAR.

G. Lutfalla, K. Gardiner, G. Uzé, 1993, Genomics.

GART, SON, IFNAR, and CRF2-4 genes cluster on human Chromosome 21 and mouse Chromosome 16

Suzanne Cheng, G. Lutfalla, K. Gardiner, 2004, Mammalian Genome.

All Creatures Great and Small: New Approaches for Understanding Down Syndrome Genetics.

K. Gardiner, R. Reeves, Anna J. Moyer, 2020, Trends in genetics : TIG.

Transcribed sequences in the human genome to be held in San Francisco, November 7 and 8, 1992. Final report, September 1, 1992--August 31, 1993

K. Gardiner, 1993 .

DENSITY-BASED IMPUTATION METHOD FOR FUZZY CLUSTER ANALYSIS OF GENE EXPRESSION MICROARRAY DATA

T. Altman, K. Gardiner, Thanh Le, 2012 .

The compositional properties of human genes

G. Bernardi, D. Mouchiroud, C. Gautier, 1991, Journal of Molecular Evolution.

Report of the ninth international workshop on the identification of transcribed sequences

R. Mural, K. Gardiner, T. Werner, 2000, Cytogenetic and Genome Research.

Comparative analysis of the DRADA A-to-I RNA editing gene from mammals, pufferfish and zebrafish.

K. Gardiner, D. Slavov, T. Crnogorac-Jurcevic, 2000, Gene.

Analysis of chromosome 21 yeast artificial chromosome (YAC) clones.

K. Gardiner, F. Tassone, S. Cheng, 1992, American journal of human genetics.

Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions

K. Gardiner, Xiaolu Sturgeon, Katheleen J. Gardiner, 2011, Mammalian Genome.

Down syndrome and the genes of human chromosome 21: current knowledge and future potentials

M. Dierssen, K. Gardiner, R. Reeves, 2008, Cytogenetic and Genome Research.

Molecular basis of pharmacotherapies for cognition in Down syndrome.

K. Gardiner, 2010, Trends in pharmacological sciences.

Machine Learning Methods Predict Locomotor Response to MK-801 in Mouse Models of Down Syndrome

Cao D. Nguyen, Krzysztof J Cios, K. Cios, 2011, Journal of neurogenetics.

Memory and Learning--Using Mouse to Model Neurobiological and Behavioural Aspects of Down Syndrome and Assess Pharmacotherapeutics.

K. Gardiner, 2009 .

Pathways to cognitive deficits in Down syndrome.

K. Gardiner, Thanh Le, Xiaolu Sturgeon, 2012, Progress in brain research.

Preserving protein profiles in tissue samples: Differing outcomes with and without heat stabilization

K. Gardiner, M. Ahmed, 2011, Journal of Neuroscience Methods.

cDNA selection from 10 Mb of chromosome 21 DNA: efficiency in transcriptional mapping and reflections of genome organization.

K. Gardiner, F. Tassone, H. Burkin, 1995, Human molecular genetics.

The effects of incorporation of bromodeoxyuridine into mammalian DNA on the migration patterns of DNA fragments subjected to pulsed-field gel electrophoresis after X irradiation or cutting with a restriction enzyme.

W. Dewey, K. Gardiner, Y. Zhu, 1994, Radiation research.

A fuzzy clustering method using Genetic Algorithm and Fuzzy Subtractive Clustering

T. Altman, K. Gardiner, Thanh Le, 2012 .

A search for genes from the dark band regions of human chromosome 21.

S. Weissman, K. Gardiner, F. Tassone, 1995, Genomics.

Report of the ninth international workshop on the molecular biology of human chromosome 21 and Down syndrome

K. Gardiner, M. Davisson, Alberto C. S. Costa, 2001, Cytogenetic and Genome Research.

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

John M. Maris, Katheleen Gardiner, John H. Bushweller, 1999, Nature Genetics.

A machine learning approach for gene expression analysis and applications

Tom Altman, Thanh Le, Katheleen Gardiner, 2013 .

Nrf2 stabilization prevents critical oxidative damage in Down syndrome cells

D. Chialvo, S. Cannas, K. Gardiner, 2018, Aging cell.

Transcriptional Dysregulation in Down Syndrome: Predictions for Altered Protein Complex Stoichiometries and Post-translational Modifications, and Consequences for Learning/Behavior Genes ELK, CREB, and the Estrogen and Glucocorticoid Receptors

K. Gardiner, 2006, Behavior genetics.

A-to-I editing of the 5HT2C receptor and behaviour.

K. Gardiner, Yunzhi Du, 2006, Briefings in functional genomics & proteomics.

The co‐occurrence of Down syndrome and autism spectrum disorder: is it because of additional genetic variations?

T. Shaikh, S. Hepburn, K. Gardiner, 2017, Prenatal diagnosis.

The co-occurrence of Down syndrome and autism spectrum disorder : is it due to additional genetic variations ? Running head : Genetic variation in co-occurring Down syndrome and ASD

T. Shaikh, S. Hepburn, K. Gardiner, 2016 .

Mutant U5A cells are complemented by an interferon‐alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster.

G. Stark, J. Reboul, G. Lutfalla, 1995, The EMBO journal.

Juxta-centromeric region of human chromosome 21 is enriched for pseudogenes and gene fragments.

S. Boyle, K. Gardiner, S. Gimenez, 1999, Gene.

Gene-dosage effects in Down syndrome and trisomic mouse models

K. Gardiner, 2004, Genome Biology.

Base composition and gene distribution: critical patterns in mammalian genome organization.

K. Gardiner, K Gardiner, Katheleen Gardiner, 1996, Trends in genetics : TIG.

A compositional map of human chromosome 21.

G. Bernardi, K. Gardiner, B. Aissani, 1990, The EMBO journal.

Partial physical map of human chromosome 21

D. Patterson, K. Gardiner, H. Drabkin, 1988, Somatic cell and molecular genetics.

Identification of Transcribed Sequences

Katheleen Gardiner, K. Gardiner, U. Hochgeschwender, 1994, Springer US.

Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

P. De Camilli, S. Antonarakis, O. Arancio, 2008, Proceedings of the National Academy of Sciences.

Mouse ascites DNA methylase: characterisation of size, proteolytic breakdown and nucleotide recognition.

K. Gardiner, R. Burdon, R. Adams, 1986, Biochimica et biophysica acta.

Leukemia breakpoint region in 3q21 is gene rich.

Y. Pekarsky, S. Schnittger, K. Gardiner, 1997, Gene.

Clonability and gene distribution on human chromosome 21: reflections of junk DNA content?

K. Gardiner, 1997, Gene.

The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21.

J. Rossier, Y. Pekarsky, K. Gardiner, 1995, Genomics.

Ts65Dn – localization of the translocation breakpoint and trisomic gene content in a mouse model for Down syndrome

K. Gardiner, M. Davisson, L. Bechtel, 2001, Cytogenetic and Genome Research.

Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions.

J. Korenberg, D. Patterson, K. Gardiner, 1990, The EMBO journal.

Down syndrome and Alzheimer's disease: Common pathways, common goals

M. Carrillo, A. Granholm, M. Krams, 2015, Alzheimer's & Dementia.

Comparative genomic analysis of the interferon/interleukin-10 receptor gene cluster.

J. Reboul, G. Lutfalla, K. Gardiner, 1999, Genome research.

Analysis of pufferfish homologues of the AT-rich human APP gene.

K. Gardiner, F. Tassone, L. Villard, 1998, Gene.

Full-sized HERV-K (HML-2) human endogenous retroviral LTR sequences on human chromosome 21: map locations and evolutionary history.

I. Mamedov, Y. Lebedev, K. Gardiner, 2001, Gene.

A-to-I pre-mRNA editing of the serotonin 2C receptor: comparisons among inbred mouse strains.

Katheleen Gardiner, Karen Kafadar, K. Kafadar, 2006, Gene.

A Hidden Markov Model for Predicting protein Interfaces

Krzysztof J. Cios, Cao D. Nguyen, Katheleen J. Gardiner, 2007, J. Bioinform. Comput. Biol..

Protein Profiles Associated With Context Fear Conditioning and Their Modulation by Memantine*

A. Dhanasekaran, K. Gardiner, Suhong Tong, 2014, Molecular & Cellular Proteomics.

Protein profiles in Tc1 mice implicate novel pathway perturbations in the Down syndrome brain

A. Dhanasekaran, K. Gardiner, V. Tybulewicz, 2013, Human molecular genetics.

Protein Dynamics Associated with Failed and Rescued Learning in the Ts65Dn Mouse Model of Down Syndrome

A. Ranjitha Dhanasekaran, A. Dhanasekaran, K. Gardiner, 2015, PloS one.

Genetic analysis of Down syndrome-associated heart defects in mice

Li Zhang, Antonio Baldini, N. Nowak, 2011, Human Genetics.

Down Syndrome: From Understanding the Neurobiology to Therapy

Stylianos E. Antonarakis, Yann Herault, Katheleen Gardiner, 2010, The Journal of Neuroscience.

The sequence of human chromosome 21 and implications for research into Down syndrome

K. Gardiner, M. Davisson, 2000, Genome Biology.

The proteins of human chromosome 21

K. Gardiner, A. C. Costa, 2006, American journal of medical genetics. Part C, Seminars in medical genetics.

Loss of correlations among proteins in brains of the Ts65Dn mouse model of down syndrome.

K. Gardiner, M. Davisson, M. Ellison, 2012, Journal of proteome research.

Evolutionary breakpoints on human chromosome 21.

K. Gardiner, M. Davisson, D. Slavov, 2001, Genomics.

Human chromosome 21-derived miRNAs are overexpressed in down syndrome brains and hearts.

Thomas D. Schmittgen, Jinmai Jiang, G. Nuovo, 2008, Biochemical and biophysical research communications.

Saturation identification of coding sequences in genomic DNA.

K. Gardiner, 1999, Methods in enzymology.

YAC clones targeting gene-rich regions of human Chromosome 3

Y. Pekarsky, K. Gardiner, S. Cheng, 1994, Mammalian Genome.

Identification and characterization of mouse homologue of human Nnp-I gene localized in 21q22.3

K. Gardiner, D. Slavov, A. Rynditch, 2000 .

Report of the eighth international workshop on the identification of transcribed sequences

R. Mural, K. Gardiner, T. Werner, 1999, Cytogenetic and Genome Research.

Structures, sequence characteristics, and synteny relationships of the transcription factor E4TF1, the splicing factor U2AF35 and the cystathionine beta synthetase genes from Fugu rubripes.

K. Gardiner, F. Tassone, L. Villard, 1999, Gene.

Dinucleotide repeat polymorphism at the D21S65 locus.

G. Rouleau, K. Gardiner, F. Tassone, 1992, Human molecular genetics.

The GABAAα5-selective Modulator, RO4938581, Rescues Protein Anomalies in the Ts65Dn Mouse Model of Down Syndrome

K. Gardiner, C. Martínez-Cué, N. Rueda, 2017, Neuroscience.

Molecular analysis and breakpoint definition of a set of human chromosome 21 somatic cell hybrids

D. Patterson, K. Gardiner, A. Joetham, 1995, Somatic cell and molecular genetics.

Pulsed field gel electrophoresis.

K. Gardiner, 1991, Analytical chemistry.

Cloning of breakpoints in 3q21 associated with hematologic malignancy.

Y. Pekarsky, E. Zabarovsky, K. Gardiner, 1995, Cancer genetics and cytogenetics.

Towards a Transcriptional Map of Human Chromosome 21

S. Weissman, K. Gardiner, F. Hisama, 1994 .

Measurement of radiation-induced DNA double-strand breaks by pulsed-field gel electrophoresis.

W. Dewey, K. Gardiner, R. Johnson, 1990, Radiation research.

Human chromosome 21/Down syndrome gene function and pathway database.

Cao D. Nguyen, K. Cios, K. Gardiner, 2005, Gene.

Building protein interaction maps for Down's syndrome.

K. Gardiner, M. Davisson, L. Crnic, 2004, Briefings in functional genomics & proteomics.

Activation of a novel gene in 3q21 and identification of intergenic fusion transcripts with ecotropic viral insertion site I in leukemia.

Y. Pekarsky, K. Gardiner, R. Wieser, 1997, Cancer research.

Age exacerbates abnormal protein expression in a mouse model of Down syndrome

K. Gardiner, M. Davisson, Suhong Tong, 2017, Neurobiology of Aging.

Alternative splicing of mammalian Intersectin 1: domain associations and tissue specificities.

K. Gardiner, A. Fortna, A. Rynditch, 2004, Genomics.

Report of the seventh international workshop on human chromosome 21 mapping 1997

K. Gardiner, M. Yaspo, 1995, Cytogenetic and Genome Research.

Altered Protein Profiles During Epileptogenesis in the Pilocarpine Mouse Model of Temporal Lobe Epilepsy

K. Gardiner, A. Brooks-Kayal, A. Carrel, 2021, Frontiers in Neurology.

The RNA component of the Bacillus subtilis RNase P. Sequence, activity, and partial secondary structure.

N. Pace, G. Olsen, C. Reich, 1986, The Journal of biological chemistry.

A-toI editing of the 5 HT 2 C receptor and behaviour

K. Gardiner, Yunzhi Du, 2006 .

Discovering relational knowledge from two disjoint sets of literatures using inductive Logic Programming

Krzysztof J. Cios, Tom Altman, Supphachai Thaicharoen, 2009, 2009 IEEE Symposium on Computational Intelligence and Data Mining.

RPPAware: A software suite to preprocess, analyze and visualize reverse phase protein array data

Katheleen J. Gardiner, A. Ranjitha Dhanasekaran, A. Dhanasekaran, 2018, J. Bioinform. Comput. Biol..

Changing Paradigms in Down Syndrome: The First International Conference of the Trisomy 21 Research Society

M. Dierssen, J. Delabar, K. Gardiner, 2016, Molecular Syndromology.

Protein annotation from protein interaction networks and Gene Ontology

Krzysztof J. Cios, Cao D. Nguyen, Katheleen J. Gardiner, 2011, J. Biomed. Informatics.

Prediction of Protein Functions from Protein Interaction Networks: A Naïve Bayes Approach

Krzysztof J. Cios, Duong Nguyen, Cao D. Nguyen, 2008, PRICAI.

Sex differences in protein expression in the mouse brain and their perturbations in a model of Down syndrome

A. Dhanasekaran, K. Gardiner, Suhong Tong, 2015, Biology of Sex Differences.

Abnormal Protein Profiles in Hippocampus of Mouse Models of Down Syndrome: Similarities with Alzheimers Disease

A. Dhanasekaran, K. Gardiner, M. Ahmed, 2014 .

Comparative analysis of the RED1 and RED2 A-to-I RNA editing genes from mammals, pufferfish and zebrafish.

K. Gardiner, D. Slavov, M. Clark, 2000, Gene.

Phylogenetic comparison of the pre-mRNA adenosine deaminase ADAR2 genes and transcripts: conservation and diversity in editing site sequence and alternative splicing patterns.

K. Gardiner, D. Slavov, Katheleen Gardiner, 2002, Gene.

Map location, genomic organization and expression patterns of the human RED1 RNA editase

K. Gardiner, F. Tassone, L. Villard, 1997, Somatic cell and molecular genetics.

Predicting pathway perturbations in Down syndrome.

K. Gardiner, 2003, Journal of neural transmission. Supplementum.

CLusFCM: an Algorithm for Predicting protein Functions Using homologies and protein Interactions

Krzysztof J. Cios, Michael Mannino, Cao D. Nguyen, 2008, J. Bioinform. Comput. Biol..

High density transcriptional mapping of chromosome 21 by hybridization selection

K. Gardiner, F. Tassone, H. Wade, 1994 .

Editing of the serotonin 2C receptor pre-mRNA: Effects of the Morris Water Maze.

K. Gardiner, M. Davisson, Katheleen J Gardiner, 2007, Gene.

Expression of trisomic proteins in Down syndrome model systems.

K. Gardiner, M. Ahmed, D. Dubach, 2013, Gene.

Alternative splicing of intersectin 1 gene pre-mRNA: expression of transcriptional isoforms

K. Gardiner, A. Rynditch, L. Tsyba, 2004 .

Criteria for gene identification and features of genome organization: analysis of 6.5 Mb of DNA sequence from human chromosome 21.

Y. Sakaki, A. Rosenthal, N. Shimizu, 2000, Gene.

Isolation of a yeast artificial chromosome spanning the 8;21 translocation breakpoint t(8;21)(q22;q22.3) in acute myelogenous leukemia.

J. Rowley, M. L. Le Beau, D. Patterson, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Age exacerbates abnormal protein expression in a mouse model of Down syndrome

K. Gardiner, M. Davisson, Suhong Tong, 2017, Neurobiology of Aging.

The sequence of human chromosome 21 and implications for research into Down syndrome

K. Gardiner, M. Davisson, 2000, Genome Biology.

RNase P of Bacillus subtilis has a RNA component.

N. Pace, K. Gardiner, 1980, The Journal of biological chemistry.

Ion dependence of the Bacillus subtilis RNase P reaction.

N. Pace, T. Marsh, K. Gardiner, 1985, The Journal of biological chemistry.