C. Bonifer

发表

Inducible chromatin priming is associated with the establishment of immunological memory in T cells

Jason Piper, S. Ott, Sarah L Bevington, 2016, The EMBO journal.

Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

Jason Piper, S. Ott, P. Cauchy, 2013, Nucleic acids research.

Wellington-bootstrap: differential DNase-seq footprinting identifies cell-type determining transcription factors

Salam A. Assi, Jason Piper, S. Ott, 2015, BMC Genomics.

Chronic FLT3-ITD Signaling in Acute Myeloid Leukemia Is Connected to a Specific Chromatin Signature

Salam A. Assi, D. Westhead, Jason Piper, 2015, Cell reports.

Subtype-specific regulatory network rewiring in acute myeloid leukemia

Salam A. Assi, P. Cauchy, L. N. Gilding, 2018, Nature Genetics.

Prospective Isolation and Characterization of Genetically and Functionally Distinct AML Subclones.

E. Vellenga, A. Diepstra, C. Bonifer, 2018, Cancer cell.

Cooperative binding of AP-1 and TEAD4 modulates the balance between vascular smooth muscle and hemogenic cell fate

Salam A. Assi, V. Kouskoff, P. Cauchy, 2016, Development.

Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

Salam A. Assi, D. Tenen, M. Care, 2012, Leukemia.

Dissecting Clonal Heterogeneity in AML.

C. Bonifer, J. Schuringa, 2020, Cancer cell.

Dynamic Gene Regulatory Networks Drive Hematopoietic Specification and Differentiation

Salam A. Assi, B. Göttgens, A. Lilly, 2016, Developmental cell.

The chicken lysozyme chromatin domain contains a second, widely expressed gene.

A. Riggs, C. Bonifer, S. Chong, 2002, Nucleic acids research.

Modelling t(8;21) acute myeloid leukaemia ‐ What have we learned?

C. Bonifer, P. S. Chin, P. Chin, 2020, MedComm.

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

Cameron S. Osborne, Salam A. Assi, C. Osborne, 2019, Cell reports.

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction

Cameron S. Osborne, Salam A. Assi, C. Osborne, 2019, Cell reports.

Epigenetic consequences of AML1–ETO action at the human c‐FMS locus

G. Morgan, G. Follows, C. Bonifer, 2003, The EMBO journal.

c-FMS chromatin structure and expression in normal and leukaemic myelopoiesis

G. Morgan, G. Follows, C. Bonifer, 2005, Oncogene.

C/EBPβ Induces Chromatin Opening at a Cell-Type-Specific Enhancer

A. Plachetka, C. Bonifer, K. Klempnauer, 2008, Molecular and Cellular Biology.

Terminal Transferase-Dependent PCR (TDPCR) for In Vivo UV Photofootprinting of Vertebrate Cells

A. Riggs, C. Bonifer, J. Kontaraki, 2001, Science's STKE.

In vivo genomic footprinting using LM-PCR methods.

C. Bonifer, P. Cockerill, H. Tagoh, 2006, Methods in molecular biology.

Promoter CpG Island MagohB Methylation at the Association and Protection from DNA Required for RNA Polymerase II The Histone Methyltransferase KMT2B Is

A. Riggs, A. F. Stewart, C. Bonifer, 2014 .

The Histone Methyltransferase KMT2B Is Required for RNA Polymerase II Association and Protection from DNA Methylation at the MagohB CpG Island Promoter

A. Riggs, A. F. Stewart, C. Bonifer, 2013, Molecular and Cellular Biology.

The regulatory domain organization of eukaryotic genomes: implications for stable gene transfer.

A. E. Sippel, G. Kollias, F. Grosveld, 1992 .

Dynamic chromatin: The regulatory domain organization of eukaryotic gene loci

A. E. Sippel, H. Saueressig, C. Bonifer, 1991, Journal of cellular biochemistry.

Regulation of the Interleukin-7 Receptor α Promoter by the Ets Transcription Factors PU.1 and GA-binding Protein in Developing B Cells*

C. Bonifer, David A Hildeman, H. Tagoh, 2007, Journal of Biological Chemistry.

Cytokine and proinflammatory gene expression in classical Hodgkin lymphoma: its more than NF-κB!

P. Cauchy, C. Bonifer, S. Kreher, 2015, Cytokine.

Two distinct auto-regulatory loops operate at the PU.1 locus in B cells and myeloid cells.

Salam A. Assi, Nicola K. Wilson, B. Göttgens, 2011, Blood.

University of Birmingham Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor binding

Salam A. Assi, M. Care, D. Westhead, 2012 .

Globin Gene Expression Is Reprogrammed in Chimeras Generated by Injecting Adult Hematopoietic Stem Cells into Mouse Blastocysts

Stefanie Sick, C. Bonifer, A. Müller, 1998, Cell.

RUNX1 positively regulates a cell adhesion and migration program in murine hemogenic endothelium prior to blood emergence.

Crispin J. Miller, V. Kouskoff, Yaoyong Li, 2014, Blood.

University of Birmingham Instructive role of MLL-fusion proteins revealed by a faithful model of t(4;11) proB acute lymphoblastic leukemia

Salam A. Assi, C. Bonifer, T. Imamura, 2016 .

Derepression of an endogenous long terminal repeat activates the CSF1R proto-oncogene in human lymphoma

Ralph Stadhouders, Michael Hummel, David F. Callen, 2010, Nature Medicine.

Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

Salam A. Assi, P. Cauchy, C. Bonifer, 2018, Leukemia.

In vitro differentiation of c-myb−/− ES cells reveals that the colony forming capacity of unilineage macrophage precursors and myeloid progenitor commitment are c-Myb independent

C. Bonifer, J. Frampton, M. Mucenski, 2000, Oncogene.

Developmental changes in the differentiation capacity of haematopoietic stem cells.

C. Bonifer, A. Müller, H. Geiger, 1998, Immunology today.

C/EBPα Activates Pre-existing and De Novo Macrophage Enhancers during Induced Pre-B Cell Transdifferentiation and Myelopoiesis

Denis Thieffry, Yang Shi, Miguel Beato, 2015, Stem cell reports.

Stem cell-specific epigenetic priming and B cell-specific transcriptional activation at the mouse Cd19 locus.

C. Bonifer, K. Walter, H. Tagoh, 2008, Blood.

Pharmacological inhibition of aberrant transcription factor complexes in inversion 16 acute myeloid leukemia.

C. Bonifer, D. Coleman, S. Potluri, 2018, Stem cell investigation.

University of Birmingham Subtype-specific regulatory network rewiring in acute myeloid leukemia

Salam A. Assi, L. N. Gilding, C. Bonifer, 2018 .

An extended set of PRDM1/BLIMP1 target genes links binding motif type to dynamic repression

M. Care, J. Bradford, D. Westhead, 2010, Nucleic acids research.

t(8;21) Acute Myeloid Leukemia as a Paradigm for the Understanding of Leukemogenesis at the Level of Gene Regulation and Chromatin Programming

C. Bonifer, O. Heidenreich, F. Barneh, 2020, Cells.

Why detailed model gene studies in higher eukaryotes are still necessary

C. Bonifer, 2013, Immunology.

Identification and interrogation of the gene regulatory network of CEBPA-double mutant acute myeloid leukemia

Salam A. Assi, C. Bonifer, P. Cockerill, 2022, Leukemia.

RUNX1/ETO blocks selectin-mediated adhesion via epigenetic silencing of PSGL-1

Salam A. Assi, C. Bonifer, R. Henschler, 2015, Oncogenesis.

Lineage-inappropriate PAX5 expression in t(8;21) acute myeloid leukemia requires signaling-mediated abrogation of polycomb repression.

So Yeon Kwon, C. Bonifer, Debleena Ray, 2013, Blood.

The replacement histone H2A.Z in a hyperacetylated form is a feature of active genes in the chicken

C. Bonifer, D. Tremethick, C. Crane-Robinson, 2005, Nucleic acids research.

Developmental activation of the lysozyme gene in chicken macrophage cells is linked to core histone acetylation at its enhancer elements

C. Bonifer, C. Crane-Robinson, A. Thorne, 2006, Nucleic acids research.

Rat antibodies as probes for the characterization of progesterone receptor A and B proteins from laying hen oviduct cytosol.

A. E. Sippel, C. Bonifer, A. Hecht, 1988, Biochimica et biophysica acta.

Protocol for the Generation of Definitive Hematopoietic Progenitors from Human Pluripotent Stem Cells

E. Stanley, C. Bonifer, A. Elefanty, 2020, STAR protocols.

Expression of RUNX1-ETO Rapidly Alters the Chromatin Landscape and Growth of Early Human Myeloid Precursor Cells

E. Stanley, C. Bonifer, A. Elefanty, 2020, Cell reports.

Long-distance chromatin mechanisms controlling tissue-specific gene locus activation.

C. Bonifer, 1999, Gene.

The Epigenetic Regulatory Machinery

C. Bonifer, P. Cockerill, 2014 .

The architecture of chicken chromosome territories changes during differentiation

Thomas Cremer, Constanze Bonifer, Christoph Cremer, 2004, BMC Cell Biology.

PLCG1 is required for AML1-ETO leukemia stem cell self-renewal.

Salam A. Assi, M. Mann, E. Stanley, 2021, Blood.

Thyroid hormone‐regulated enhancer blocking: cooperation of CTCF and thyroid hormone receptor

Victor V Lobanenkov, G. Filippova, C. Bonifer, 2003, The EMBO journal.

The LPS-Induced Transcriptional Upregulation of the Chicken Lysozyme Locus Involves CTCF Eviction and Noncoding RNA Transcription

C. Bonifer, P. Cockerill, P. Lefevre, 2008, Molecular cell.

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

F. Rosenbauer, D. Lenze, S. Heinz, 2011, Blood.

Lymphodepletion in the ApcMin/+ mouse model of intestinal tumorigenesis.

K. Maclennan, G. Cook, C. Bonifer, 2004, Blood.

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

Salam A. Assi, J. Allan, C. Bonifer, 2018, Cancer cell.

Identification of gene specific cis-regulatory elements during differentiation of mouse embryonic stem cells: An integrative approach using high-throughput datasets

Berthold Gottgens, Salam A. Assi, M S Vijayabaskar, 2019, PLoS Comput. Biol..

Chromatin priming of genes in development: Concepts, mechanisms and consequences.

C. Bonifer, P. Cockerill, 2017, Experimental hematology.

Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro.

A. Riggs, C. Bonifer, S. Chong, 2004, Blood.

Developmentally Regulated Recruitment of Transcription Factors and Chromatin Modification Activities to Chicken Lysozyme cis-Regulatory Elements In Vivo

Nicola K. Wilson, A. Riggs, N. Wilson, 2003, Molecular and Cellular Biology.

Chromatin programming by developmentally regulated transcription factors: lessons from the study of haematopoietic stem cell specification and differentiation

C. Bonifer, N. Obier, 2016, FEBS letters.

Chromatin fine structure profiles for a developmentally regulated gene: reorganization of the lysozyme locus before trans-activator binding and gene expression.

A. Riggs, C. Bonifer, J. Kontaraki, 2000, Genes & development.

Reduction in the resident intestinal myelomonocytic cell population occurs during ApcMin/+ mouse intestinal tumorigenesis

C. Bonifer, A. Markham, M. Hull, 2021, Oncology letters.

The RUNX1–PU.1 axis in the control of hematopoiesis

P. Cauchy, C. Bonifer, M. Imperato, 2015, International Journal of Hematology.

Stepwise activation of enhancer and promoter regions of the B cell commitment gene Pax5 in early lymphopoiesis.

M. Busslinger, C. Bonifer, H. Tagoh, 2009, Immunity.

Lymphodepletion in the Apc Min/+ mouse model of intestinal tumorigenesis Short title:Lymphodepletion in the Apc Min/+ mouse

K. Maclennan, G. Cook, C. Bonifer, 2013 .

Early chromatin unfolding by RUNX1: a molecular explanation for differential requirements during specification versus maintenance of the hematopoietic gene expression program.

V. Kouskoff, D. Tenen, A. Fisher, 2009, Blood.

The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis.

D. Hume, C. Bonifer, D. Hume, 2008, Frontiers in Bioscience.

Epigenetic mechanisms regulating normal and malignant haematopoiesis: new therapeutic targets for clinical medicine

C. Bonifer, D. Bowen, 2010, Expert Reviews in Molecular Medicine.

The transcriptional regulation of normal and malignant blood cell development

C. Bonifer, B. Edginton-White, 2021, The FEBS journal.

RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis

Salam A. Assi, B. Göttgens, V. Kouskoff, 2012, The EMBO journal.

Explorer The Function of the Conserved Regulatory Element within the Second Intron of the Mammalian Csf 1 r Locus

D. Hume, C. Bonifer, M. Bouhlel, 2017 .

The Function of the Conserved Regulatory Element within the Second Intron of the Mammalian Csf1r Locus

D. Hume, C. Bonifer, M. Bouhlel, 2013, PloS one.

NFATc1 releases BCL6‐dependent repression of CCR2 agonist expression in peritoneal macrophages from Saccharomyces cerevisiae infected mice

K. Knobeloch, A. Waisman, C. Bonifer, 2016, European journal of immunology.

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

Salam A. Assi, C. Bonifer, O. Heidenreich, 2021, Nature Communications.

RUNX1/RUNX1T1 controls alternative splicing in the t(8;21)-positive acute myeloid leukemia cells

C. Bonifer, O. Heidenreich, V. Grinev, 2019, bioRxiv.

activation at the mouse Cd19 locus specific transcriptional - specific epigenetic priming and B cell - Stem cell

C. Bonifer, K. Walter, H. Tagoh, 2013 .

Regulation of the PU.1 Gene by Sense and Functional Antisense RNAs Generated through the Same Chromatin Architecture.

F. Rosenbauer, D. Tenen, Tajhal Dayaram, 2006 .

Differential regulation of sense and antisense promoter activity at the Csf1R locus in B cells by the transcription factor PAX5.

Nicola K. Wilson, N. Wilson, S. Philipsen, 2011, Experimental hematology.

Aberrant expression of CD19 in AML with t(8;21) involves a poised chromatin structure and PAX5

G. Follows, C. Bonifer, P. Cockerill, 2010, Oncogene.

The mechanism of repression of the myeloid‐specific c‐fms gene by Pax5 during B lineage restriction

Nicola K. Wilson, N. Wilson, M. Busslinger, 2006, The EMBO journal.

The regulation of chromatin and DNA-methylation patterns in blood cell development.

C. Bonifer, H. Tagoh, P. Lefevre, 2006, Current topics in microbiology and immunology.

Aberrant Transcriptional Programming in Blood Cancers

C. Bonifer, P. Cockerill, A. Ptasinska, 2015 .

Reduced c-myb Expression Levels Affect Hematopoietic Development In Vitro

C. Bonifer, D. Clarke, Chen Jieping, 2007, International journal of hematology.

Developmental regulation of eukaryotic gene loci: which cis-regulatory information is required?

C. Bonifer, Constanze Bonifer, 2000, Trends in genetics : TIG.

The Role of the Ubiquitously Expressed Transcription Factor Sp1 in Tissue-specific Transcriptional Regulation and in Disease

C. Bonifer, L. O’Connor, J. Gilmour, 2016, The Yale journal of biology and medicine.

Differentiation-dependent Alterations in Histone Methylation and Chromatin Architecture at the Inducible Chicken Lysozyme Gene*

C. Bonifer, H. Tagoh, M. Hoogenkamp, 2005, Journal of Biological Chemistry.

microRNA expression Macrophage development from HSCs requires PU.1-coordinated

F. Rosenbauer, D. Lenze, S. Heinz, 2011 .

The Pu.1 Locus Is Differentially Regulated at the Level of Chromatin Structure and Noncoding Transcription by Alternate Mechanisms at Distinct Developmental Stages of Hematopoiesis

D. Tenen, C. Bonifer, P. Cockerill, 2007, Molecular and Cellular Biology.

Chromatin mechanisms regulating gene expression in health and disease.

C. Bonifer, P. Cockerill, 2011, Advances in experimental medicine and biology.

Lineage switching in MLL-AF 4 leukaemias 1 Epigenetic regulator genes direct lineage switching in MLL-AF 4 leukaemia 1

Salam A. Assi, J. Hehir-Kwa, Z. Kingsbury, 2021 .

Isoform-specific and signaling-dependent propagation of acute myeloid leukemia by Wilms tumor 1.

Salam A. Assi, S. Moriya, N. Seki, 2021, Cell reports.

Identification of common and distinct epigenetic re-programming properties of Core-Binding Factor (CBF) Fusion Proteins

P. Cauchy, C. Bonifer, P. Cockerill, 2016 .

cis-Regulatory Remodeling of the SCL Locus during Vertebrate Evolution

B. Göttgens, A. Green, G. Follows, 2010, Molecular and Cellular Biology.

Repeat element-driven activation of proto-oncogenes in human malignancies

C. Bonifer, B. Lamprecht, S. Mathas, 2010, Cell cycle.

The Inducible Tissue-Specific Expression of the Human IL-3/GM-CSF Locus Is Controlled by a Complex Array of Developmentally Regulated Enhancers

A. Bert, A. West, E. Bertrand, 2012, The Journal of Immunology.

PU.1 expression is modulated by the balance of functional sense and antisense RNAs regulated by a shared cis-regulatory element.

F. Rosenbauer, D. Tenen, Tajhal Dayaram, 2008, Genes & development.

GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment.

Nicola K. Wilson, B. Göttgens, N. Wilson, 2012, Blood.

Epigenetic silencing of the c‐fms locus during B‐lymphopoiesis occurs in discrete steps and is reversible

Nicola K. Wilson, N. Wilson, D. Hume, 2004, The EMBO journal.

PAP-LMPCR: an improved, sequence-selective method for the in vivo analysis of transcription factor occupancy and chromatin fine structure.

A. Riggs, C. Bonifer, Richard M. Ingram, 2011, Methods in molecular biology.

How transcription factors program chromatin--lessons from studies of the regulation of myeloid-specific genes.

C. Bonifer, H. Tagoh, M. Hoogenkamp, 2008, Seminars in immunology.

A Two-Step, PU.1-Dependent Mechanism for Developmentally Regulated Chromatin Remodeling and Transcription of the c-fms Gene

Nicola K. Wilson, N. Wilson, Harinder Singh, 2006, Molecular and Cellular Biology.

Epigenetic Plasticity of Hematopoietic Cells

Constanze Bonifer, C. Bonifer, 2005, Cell cycle.

Rapid, solid-phase based automated analysis of chromatin structure and transcription factor occupancy in living eukaryotic cells

A. Riggs, C. Bonifer, H. Tagoh, 2005, Nucleic acids research.

Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci.

G. Morgan, G. Follows, C. Bonifer, 2003, Nucleic acids research.

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells.

A. Riggs, D. Hume, C. Bonifer, 2002, Genes & development.

A highly conserved c‐fms gene intronic element controls macrophage‐specific and regulated expression

S. R. Himes, D. Hume, C. Bonifer, 2001, Journal of leukocyte biology.

A Functional Chromatin Domain Does Not Resist X Chromosome Inactivation: Silencing of cLys Correlates with Methylation of a Dual Promoter-Replication Origin

A. Riggs, C. Bonifer, S. Chong, 2002, Molecular and Cellular Biology.

Chromatin regulation by RUNX1.

C. Bonifer, M. Hoogenkamp, Monika Lichtinger, 2010, Blood cells, molecules & diseases.

The Chicken Lysozyme Locus as a Paradigm for the Complex Developmental Regulation of Eukaryotic Gene Loci*

C. Bonifer, M. C. Huber, C. Bonifer, 1997, The Journal of Biological Chemistry.

Role of Positive and Negative Cis-regulatory Elements in the Transcriptional Activation of the Lysozyme Locus in Developing Macrophages of Transgenic Mice*

Constanze Bonifer, H. Kohler, C. Bonifer, 1997, The Journal of Biological Chemistry.

Chromatin domains constitute regulatory units for the control of eukaryotic genes.

A. E. Sippel, H. Saueressig, C. Bonifer, 1993, Cold Spring Harbor symposia on quantitative biology.

Identification of CCND2 As a RUNX1/ETO Target Required for Leukaemic Propagation

C. Bonifer, O. Heidenreich, H. Blair, 2016 .

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

Salam A. Assi, D. Tenen, D. Westhead, 2014, Cell reports.

Runx1 Structure and Function in Blood Cell Development.

V. Kouskoff, C. Bonifer, G. Lacaud, 2017, Advances in experimental medicine and biology.

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

N. Wilson, Y. Okuno, D. Tenen, 2011, The EMBO journal.

Paracrine cyclooxygenase-2 activity by macrophages drives colorectal adenoma progression in the ApcMin/+ mouse model of intestinal tumorigenesis

C. Bonifer, E. Cartwright, A. Markham, 2017, Scientific Reports.

Instructive Role of MLL-Fusion Proteins Revealed by a Model of t(4;11) Pro-B Acute Lymphoblastic Leukemia.

Salam A. Assi, C. Bonifer, T. Imamura, 2016, Cancer cell.

PAP-LMPCR for improved, allele-specific footprinting and automated chromatin fine structure analysis

A. Riggs, C. Bonifer, M. Hoogenkamp, 2008, Nucleic acids research.

promoter by multiple Sp1 binding sites Regulation of the human endothelial cell protein C receptor gene

C. Bonifer, P. Cockerill, James B. Rance, 2013 .

Regulation of the human endothelial cell protein C receptor gene promoter by multiple Sp1 binding sites.

G. Follows, C. Bonifer, P. Cockerill, 2003, Blood.

The Oncogenic Transcript ion Factor RUNX 1 / ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation Graphical

Salam A. Assi, J. Allan, C. Bonifer, 2018 .

UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO

Salam A. Assi, C. Bloomfield, N. Nassar, 2016, Leukemia.

Lymphoma Global long terminal repeat activation participates in establishing the unique gene expression programme of classical Hodgkin lymphoma

Salam A. Assi, P. Cauchy, C. Bonifer, 2018 .

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma

R. Siebert, G. Lenz, B. Dörken, 2014, Proceedings of the National Academy of Sciences.

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.

Salam A. Assi, M. Weirauch, B. Aronow, 2017, Blood.

Robust hematopoietic specification requires the ubiquitous Sp1 and Sp3 transcription factors

S. Philipsen, C. Bonifer, J. Cazier, 2019, Epigenetics & Chromatin.

Epigenetic regulator genes direct lineage switching in MLL-AF4 leukaemia

Salam A. Assi, J. Hehir-Kwa, Z. Kingsbury, 2021, bioRxiv.

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.

D. Tenen, V. Lefebvre, D. Scadden, 2013, Cancer cell.

C/EBPα overrides epigenetic reprogramming by oncogenic transcription factors in acute myeloid leukemia.

Salam A. Assi, C. Bonifer, P. Cockerill, 2018, Blood advances.

Sox4 Is aK ey Oncogenic Target in C/EBPa Mutant Acute Myeloid Leukemia

D. Tenen, D. Scadden, Hong Zhang, 2013 .

Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers

Mazhar Adli, J. A. Pulikkan, K. Janes, 2016, EBioMedicine.

A crucial role for the ubiquitously expressed transcription factor Sp1 at early stages of hematopoietic specification

Salam A. Assi, D. Westhead, S. Philipsen, 2014, Development.

Tissue‐specific Locus Control: Structure and Function

C. Bonifer, 2007 .

Runx proteins regulate Foxp3 expression

A. Fisher, C. Bonifer, S. Hadjur, 2009, The Journal of experimental medicine.

Herpesvirus saimiri-based gene delivery vectors maintain heterologous expression throughout mouse embryonic stem cell differentiation in vitro

C. Bonifer, A. Whitehouse, S. Kinsey, 2000, Gene Therapy.

A FOXO1-induced oncogenic network defines the AML1-ETO pre-leukemic program Running title: FOXO1 is an oncogenic mediator in AML1-ETO leukemia Scientific category: Myeloid Neoplasia

M. Weirauch, B. Aronow, Jingsong Zhang, 2017 .

Developmental-stage-dependent transcriptional response to leukaemic oncogene expression

Salam A. Assi, K. Regha, C. Bonifer, 2015, Nature Communications.

The leukemia-associated RUNX1/ETO oncoprotein confers a mutator phenotype

Salam A. Assi, J. Allan, C. Bonifer, 2015, Leukemia.

Transcription Factor PU.1 Controls Transcription Start Site Positioning and Alternative TLR4 Promoter Usage*

M. Rehli, M. Hornef, C. Bonifer, 2007, Journal of Biological Chemistry.

Characterization of RNA aptamers that disrupt the RUNX1–CBFβ/DNA complex

Stuart E. Knowling, C. Bonifer, D. Bunka, 2009, Nucleic Acids Research.

Leukemic stem cells hijack lineage inappropriate signalling pathways to promote their growth

Salam A. Assi, C. Bonifer, P. Cockerill, 2023, bioRxiv.

Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

K. Regha, C. Bonifer, P. Keane, 2020, Life Science Alliance.

Subtype-specific regulatory network rewiring in acute myeloid leukemia

Salam A. Assi, P. Cauchy, L. N. Gilding, 2018, Nature Genetics.

RUNX1/ETO and mutant KIT both contribute to programming the transcriptional and chromatin landscape in t(8;21) AML.

Salam A. Assi, C. Bonifer, P. Cockerill, 2020, Experimental hematology.

RUNX1-ETO induction rapidly alters chromatin landscape and growth of a specific sub-population of hESC-derived myeloid precursor cells by interfering with RUNX1 regulation

E. Stanley, C. Bonifer, A. Elefanty, 2019, bioRxiv.

Rewiring of the Transcription Factor Network in Acute Myeloid Leukemia

C. Bonifer, P. Cockerill, S. A. Assi, 2019, Cancer informatics.

C/EBPβ Induces Chromatin Opening at a Cell-Type-Specific Enhancer

A. Plachetka, C. Bonifer, K. Klempnauer, 2008, Molecular and Cellular Biology.

Identification of factors mediating the developmental regulation of the early acting -3.9 kb chicken lysozyme enhancer element.

C. Bonifer, P. Lefevre, J. Kontaraki, 2001, Nucleic acids research.

Standing at odds: mutated RAS and hematopoietic stem cells

C. Bonifer, Monica Nafria, 2019, Haematologica.

RUNX1-ETO and RUNX1-EVI1 Differentially Reprogram the Chromatin Landscape in t(8;21) and t(3;21) AML

Salam A. Assi, P. Cauchy, C. Bonifer, 2017, Cell reports.

RUNX 1-ETO and RUNX 1E VI 1 Differentially Reprogram the Chromatin Landscape in t ( 8 ; 21 ) and t ( 3 ; 21 ) AML Graphical

P. Cauchy, C. Bonifer, P. Cockerill, 2022 .

Identification and characterization of enhancer elements controlling cell type-specific and signalling dependent chromatin programming during hematopoietic development

C. Bonifer, B. Edginton-White, Alexander Maytum, 2023, Stem cell investigation.

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

Salam A. Assi, C. Bonifer, P. Cockerill, 2023, bioRxiv.

RUNX1-EVI1 disrupts lineage determination and the cell cycle by interfering with RUNX1 and EVI1 driven gene regulatory networks

C. Bonifer, P. Keane, S. Kellaway, 2020, Haematologica.

Delineating MEIS1 cis-regulatory elements active in hematopoietic cells

B. Göttgens, M. Hirst, M. Bilenky, 2014, Leukemia.

Chromatin Structure Profiling Identifies Crucial Regulators of Tumor Maintenance.

C. Bonifer, P. Cockerill, 2015, Trends in cancer.

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML that Regulates Differentiation Block and Self-Renewal

Salam A. Assi, D. Tenen, D. Westhead, 2014, Cell reports.

Chronic growth factor receptor signaling and lineage inappropriate gene expression in AML: The polycomb connection

So Yeon Kwon, C. Bonifer, Debleena Ray, 2013, Cell cycle.

Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association

Salam A. Assi, E. Stanley, L. Bullinger, 2023 .

Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells.

A. Riggs, D. Hume, C. Bonifer, 2002, Genes & development.

The architecture of chicken chromosome territories changes during differentiation

T. Cremer, C. Cremer, C. Bonifer, 2004, BMC Cell Biology.

Localization of cyclooxygenase-2 in human sporadic colorectal adenomas.

C. Bonifer, E. Cartwright, A. Windsor, 2000, The American journal of pathology.

Molecular basis of haematological disease caused by inherited or acquired RUNX1 mutations.

C. Bonifer, P. Cockerill, M. Raghavan, 2022, Experimental hematology.

C. Bonifer, A. Markham, N. Scott, 2022 .

A heterozygous CEBPA mutation disrupting the bZIP domain causes MDS disease progression

Turki M. Sobahy, C. Bonifer, E. Barragán, 2023, bioRxiv.

Subtype-specific regulatory network rewiring in acute myeloid 1 leukemia 2

Salam A. Assi, L. N. Gilding, C. Bonifer, 2018 .

The Oncogenic Transcription Factor RUNX1/ETO Corrupts Cell Cycle Regulation to Drive Leukemic Transformation

Cameron S. Osborne, Salam A. Assi, J. Allan, 2019, Cancer cell.

The hematopoietic master regulator RUNX1 reshapes the epigenetic landscape at the onset of hematopoiesis

Salam A. Assi, B. Göttgens, V. Kouskoff, 2013, Epigenetics & Chromatin.

An in vitro differentiation system for the examination of transgene activation in mouse macrophages.

A. E. Sippel, M. Wiles, C. Bonifer, 1994, DNA and Cell Biology.

Rachel promoter by multiple Sp 1 binding sites Regulation of the human endothelial cell protein C receptor gene

G. Follows, C. Bonifer, P. Cockerill, 2003 .

A new type of transcriptional reprogramming by an IRF4 mutation in lymphoma

Salam A. Assi, U. Pannicke, K. Schwarz, 2022, bioRxiv.

Evolution of gene regulation as revealed by differential regulation of the chicken lysozyme transgene and the endogenous mouse lysozyme gene in mouse macrophages.

A. E. Sippel, C. Bonifer, F. Bosch, 1994, European journal of biochemistry.

Runx proteins regulate Foxp3 expression

A. Fisher, C. Bonifer, S. Hadjur, 2009, The Journal of experimental medicine.

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program.

Salam A. Assi, M. Weirauch, B. Aronow, 2017, Blood.

Identification of a Dynamic Core Transcriptional Network in t(8;21) AML Regulating Differentiation Block and Self-Renewal

Salam A. Assi, D. Tenen, D. Westhead, 2014 .

Sox4 is a key oncogenic target in C/EBPα mutant acute myeloid leukemia.

D. Tenen, V. Lefebvre, D. Scadden, 2013, Cancer Cell.

University of Birmingham UBASH3B/Sts-1-CBL axis regulates myeloid proliferation in human preleukemia induced by AML1-ETO

Salam A. Assi, C. Bloomfield, C. Bonifer, 2015 .

Macrophage development from HSCs requires PU.1-coordinated microRNA expression.

F. Rosenbauer, D. Lenze, S. Heinz, 2011, Blood.

The Transcriptome Heterogeneity of MLL-Fusion ALL Is Driven By Fusion Partners Via Distinct Chromatin Binding

C. Bonifer, T. Milne, J. Mulloy, 2016 .

RUNX1 regulates the CD34 gene in haematopoietic stem cells by mediating interactions with a distal regulatory element

Nicola K. Wilson, Y. Okuno, D. Tenen, 2011, The EMBO journal.

The Co-operation of RUNX1 with LDB1, CDK9 and BRD4 Drives Transcription Factor Complex Relocation During Haematopoietic Specification

Salam A. Assi, C. Bonifer, N. Obier, 2018, Scientific Reports.

Chromatin priming of genes in development: Concepts, mechanisms and consequences.

C. Bonifer, P. Cockerill, 2017, Experimental hematology.

Epigenetic regulator genes direct lineage switching in MLL/AF4 leukemia

Salam A. Assi, J. Hehir-Kwa, Z. Kingsbury, 2022, Blood.

Wellington: a novel method for the accurate identification of digital genomic footprints from DNase-seq data

Jason Piper, S. Ott, P. Cauchy, 2014, Nucleic Acids Research.

University of Birmingham Rewiring of the transcription factor network in acute myeloid leukemia

C. Bonifer, P. Cockerill, 2019 .

Transcriptional reprogramming by mutated IRF4 in lymphoma

Salam A. Assi, U. Pannicke, W. Wasserman, 2023, Nature communications.

Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth

Salam A. Assi, C. Bonifer, P. Cockerill, 2024, Nature communications.

Gene regulatory network analysis predicts cooperating transcription factor regulons required for FLT3-ITD+ AML growth

Salam A. Assi, C. Bonifer, P. Cockerill, 2023, Cell reports.

Chromatin priming elements direct tissue-specific gene activity before hematopoietic specification

C. Bonifer, P. Cockerill, J. Cazier, 2023, Life Science Alliance.

University of Birmingham Developmental activation of the lysozyme gene in chicken macrophage cells is linked to core histone acetylation at its enhancer elements

C. Bonifer, C. Crane-Robinson, A. Thorne, 2006 .