J. Svaren

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A nucleosome precludes binding of the transcription factor Pho4 in vivo to a critical target site in the PHO5 promoter.

J. Schmitz, W. Hörz, U. Venter, 1994, The EMBO journal.

Schwann cell transcript biomarkers for hereditary neuropathy skin biopsies

J. Svaren, John J. Moran, Xingyao Wu, 2019, Annals of neurology.

SOX10 directly modulates ERBB3 transcription via an intronic neural crest enhancer

Stephen L. Johnson, A. McCallion, W. Pavan, 2011, BMC Developmental Biology.

In Silico Pooling of ChIP-seq Control Experiments

S. Keleş, J. Svaren, R. Srinivasan, 2014, PloS one.

Neurofilament light plasma concentration positively associates with age and negatively associates with weight and height in the dog

H. Zetterberg, J. Svaren, A. Heslegrave, 2020, Neuroscience Letters.

Direct Regulation of Myelin Protein Zero Expression by the Egr2 Transactivator*

J. Svaren, L. Wrabetz, S. Leblanc, 2006, Journal of Biological Chemistry.

Analysis of the competition between nucleosome formation and transcription factor binding.

R. Chalkley, J. Svaren, L. Sealy, 1994, The Journal of biological chemistry.

Active Gene Repression by the Egr2·NAB Complex during Peripheral Nerve Myelination*

J. Svaren, L. Wrabetz, R. Srinivasan, 2008, Journal of Biological Chemistry.

Response Gene 1-Deficient Mice Choriomeningitis Virus in Early Growth CD 8 T Cell Responses to Lymphocytic

J. Svaren, M. Suresh, J. Grayson, 2004 .

CD8 T Cell Responses to Lymphocytic Choriomeningitis Virus in Early Growth Response Gene 1-Deficient Mice1

J. Svaren, M. Suresh, J. Grayson, 2004, The Journal of Immunology.

Transcription factor early growth response‐1 induction mediates inflammatory gene expression and brain damage following transient focal ischemia

J. Svaren, R. Vemuganti, K. Tureyen, 2008, Journal of neurochemistry.

A methyl‐deficient diet modifies histone methylation and alters Igf2 and H19 repression in the prostate

R. Weindruch, J. Svaren, R. Srinivasan, 2008, The Prostate.

Bach2 Regulates Homeostasis of Foxp3+ Regulatory T Cells and Protects against Fatal Lung Disease in Mice

J. Svaren, E. Kim, M. Suresh, 2014, The Journal of Immunology.

Transmembrane protease serine 5: a novel Schwann cell plasma marker for CMT1A

J. Svaren, K. Call, John J. Moran, 2019, Annals of clinical and translational neurology.

Early Growth Response 1 (Egr1) Regulates Cholesterol Biosynthetic Gene Expression*

J. Svaren, A. Gillian-Daniel, Camila Lopez‐Anido, 2011, The Journal of Biological Chemistry.

mRNA expression of novel CGRP1 receptors and their activity-modifying proteins in hypoxic rat lung.

J. Svaren, I. Keith, X. Qing, 2001, American journal of physiology. Lung cellular and molecular physiology.

Myelin protein zero mutations and the unfolded protein response in Charcot Marie Tooth disease type 1B

J. Svaren, John J. Moran, Xingyao Wu, 2018, Annals of clinical and translational neurology.

Pmp22 Super-enhancer Deletion Causes Tomacula Formation and Conduction Block in Peripheral Nerves.

J. Svaren, John J. Moran, Jun Li, 2020, Human molecular genetics.

A Novel Pathway Links Oxidative Stress to Loss of Insulin Growth Factor-2 (IGF2) Imprinting through NF-κB Activation

J. Svaren, S. Miyamoto, D. Jarrard, 2014, PloS one.

Multivalent recognition of histone tails by the PHD fingers of CHD5.

J. Denu, J. Svaren, C. Musselman, 2012, Biochemistry.

Bi‐allelic mutations in EGR2 cause autosomal recessive demyelinating neuropathy by disrupting the EGR2‐NAB complex

J. Svaren, S. Pascual-Pascual, C. Espinós, 2020, European journal of neurology.

Yy1 as a molecular link between neuregulin and transcriptional modulation of peripheral myelination

J. Svaren, P. Casaccia, J. Dupree, 2010, Nature Neuroscience.

Search for mutations in the EGR2 corepressor proteins, NAB1 and NAB2, in human peripheral neuropathies

K. Venken, J. Svaren, E. Bellone, 2002, Neurogenetics.

Cell transplantation strategies for acquired and inherited disorders of peripheral myelin

J. Svaren, Kevin J. Kim, R. Baloh, 2018, Annals of clinical and translational neurology.

PMP22 antisense oligonucleotides reverse Charcot-Marie-Tooth disease type 1A features in rodent models

J. Svaren, S. Scherer, M. Scheideler, 2017, The Journal of clinical investigation.

Identification of equine P-selectin glycoprotein ligand-1 (CD162)

J. Svaren, B. Wagner, Jin Xu, 2004, Mammalian Genome.

Expression of immune response genes in the stifle joint of dogs with oligoarthritis and degenerative cranial cruciate ligament rupture.

S. Schaefer, P. Manley, J. Svaren, 2007, Veterinary immunology and immunopathology.

BACH2 in TRegs Limits the Number of Adipose Tissue Regulatory T Cells and Restrains Type 2 Immunity to Fungal Allergens

J. Svaren, Woojong Lee, M. Suresh, 2022, Journal of immunology research.

The molecular machinery of myelin gene transcription in Schwann cells

J. Svaren, D. Meijer, 2008, Glia.

Nab proteins are essential for peripheral nervous system myelination

R. Schmidt, J. Milbrandt, R. Nagarajan, 2005, Nature Neuroscience.

Genome-wide analysis of EGR2/SOX10 binding in myelinating peripheral nerve

Sunduz Keles, Guannan Sun, S. Keleş, 2012, Nucleic acids research.

YAP and TAZ control peripheral myelination and the expression of laminin receptors in Schwann cells

Ruogang Zhao, J. Wrana, A. Gregorieff, 2016, Nature Neuroscience.

Activation of luteinizing hormone beta gene by gonadotropin-releasing hormone requires the synergy of early growth response-1 and steroidogenic factor-1.

Y. Sadovsky, J. Svaren, C. Dorn, 1999, The Journal of biological chemistry.

Dynamic Regulation of Schwann Cell Enhancers after Peripheral Nerve Injury*

S. Keleş, J. Svaren, Guannan Sun, 2015, The Journal of Biological Chemistry.

Distal enhancers upstream of the Charcot-Marie-Tooth type 1A disease gene PMP22.

S. Keleş, J. Svaren, A. Antonellis, 2012, Human molecular genetics.

MYRF Is a Membrane-Associated Transcription Factor That Autoproteolytically Cleaves to Directly Activate Myelin Genes

B. Barres, M. Wegner, V. Perreau, 2013, PLoS biology.

Histones, nucleosomes and transcription.

J. Svaren, W. Hörz, W. Hörz, 1993, Current opinion in genetics & development.

Role of cell cycle regulator p19ARF in regulating T cell responses.

J. Svaren, M. Suresh, Xiaoyan Gao, 2002, Cellular immunology.

JUN Regulation of Injury-Induced Enhancers in Schwann Cells

J. Svaren, Raghu Ramesh, R. Awatramani, 2022, The Journal of Neuroscience.

Polycomb repression regulates Schwann cell proliferation and axon regeneration after nerve injury

J. Svaren, John J. Moran, Phu Duong, 2018, Glia.

Locus‐wide identification of Egr2/Krox20 regulatory targets in myelin genes

Sunduz Keles, Rakesh Nagarajan, Guannan Sun, 2010, Journal of neurochemistry.

Transcription factors vs nucleosomes: regulation of the PHO5 promoter in yeast.

J. Svaren, W Hörz, J Svaren, 1997, Trends in biochemical sciences.

H3K27 demethylases are dispensable for activation of Polycomb-regulated injury response genes in peripheral nerve

J. Svaren, John J. Moran, Raghu Ramesh, 2021, The Journal of biological chemistry.

Developmental Regulation of MicroRNA Expression in Schwann Cells

J. Svaren, R. Srinivasan, Camila Lopez‐Anido, 2011, Molecular and Cellular Biology.

Regulation of gene expression by nucleosomes.

J. Svaren, W. Hörz, 1996, Current opinion in genetics & development.

Modulation of Schwann cell homeostasis by the BAP1 deubiquitinase

J. Svaren, Raghu Ramesh, Phu Duong, 2023, Glia.

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

T. Gordon, R. Mirsky, J. Svaren, 2020, bioRxiv.

Neuregulin 1 type III improves peripheral nerve myelination in a mouse model of congenital hypomyelinating neuropathy.

K. Nave, J. Svaren, L. Wrabetz, 2018, Human molecular genetics.

Regulation of Peripheral Nerve Myelin Maintenance by Gene Repression through Polycomb Repressive Complex 2

S. Orkin, J. Svaren, R. Srinivasan, 2015, The Journal of Neuroscience.

Genome-Edited Cell Lines for High-Throughput Screening.

James Inglese, J. Svaren, John J. Moran, 2018, Methods in molecular biology.

Epigenetic Control of Schwann Cells

J. Svaren, Ki H. Ma, 2018, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

Epigenomic Regulation of Schwann Cell Reprogramming in Peripheral Nerve Injury

J. Svaren, Holly A Hung, Ki H. Ma, 2016, The Journal of Neuroscience.

EGR2 Mutations in Inherited Neuropathies Dominant-Negatively Inhibit Myelin Gene Expression

M. Watson, J. Milbrandt, R. Nagarajan, 2001, Neuron.

MicroRNA and transcriptional crosstalk in myelinating glia

J. Svaren, 2014, Neurochemistry International.

Aging and cancer-related loss of insulin-like growth factor 2 imprinting in the mouse and human prostate.

R. Weindruch, J. Svaren, R. Srinivasan, 2008, Cancer research.

Egr2-dependent microRNA-138 is dispensable for peripheral nerve myelination

J. Svaren, R. Awatramani, Hsin-Pin Lin, 2018, Scientific Reports.

Differential requirement for Lck during primary and memory CD8+ T cell responses

J. Svaren, R. Zamoyska, M. Suresh, 2006, Proceedings of the National Academy of Sciences.

Novel mutants of NAB corepressors enhance activation by Egr transactivators

J. Milbrandt, J. Svaren, T. Golda, 1998, The EMBO journal.

Regulating PMP22 expression as a dosage sensitive neuropathy gene

J. Svaren, M. Shy, H. Pantera, 2020, Brain Research.

Variation in SIPA1L2 is correlated with phenotype modification in Charcot– Marie– Tooth disease type 1A

F. Baas, S. Züchner, G. Beecham, 2019, Annals of neurology.

Charcot-Marie-Tooth disease

J. Svaren, Phu Duong, 2019, Chromatin Signaling and Neurological Disorders.

Regulation of the neuropathy-associated Pmp22 gene by a distal super-enhancer

A. Dutra, J. Svaren, John J. Moran, 2018, Human molecular genetics.

Tead1 regulates the expression of Peripheral Myelin Protein 22 during Schwann cell development.

J. Svaren, A. Antonellis, John J. Moran, 2016, Human molecular genetics.

Genome Editing-Enabled HTS Assays Expand Drug Target Pathways for Charcot–Marie–Tooth Disease

R. Guha, James Inglese, Yolanda Santiago, 2014, ACS chemical biology.

Specification of Macroglia by Transcription Factors: Schwann Cells

J. Svaren, D. Meijer, 2013 .

Neurokinin-B Transcription in Erythroid Cells

Jeffery L. Miller, J. Svaren, E. Bresnick, 2004, Journal of Biological Chemistry.

A Novel Activation Function for NAB Proteins in EGR-dependent Transcription of the Luteinizing Hormone β Gene*

J. Milbrandt, J. Svaren, B. Sevetson, 2000, The Journal of Biological Chemistry.

Functional consequences of mutations in the early growth response 2 gene (EGR2) correlate with severity of human myelinopathies.

J. Lupski, J. Milbrandt, J. Svaren, 1999, Human molecular genetics.

Nab1, a Corepressor of NGFI-A (Egr-1), Contains an Active Transcriptional Repression Domain

J. Milbrandt, J. Svaren, D. Zimonjic, 1998, Molecular and Cellular Biology.

NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli

J. Milbrandt, J. Svaren, D. Zimonjic, 1996, Molecular and cellular biology.

SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2.

J. Svaren, A. Antonellis, E. Fogarty, 2016, Human molecular genetics.

Major transcriptional regulators of the myelination process : Oct 6 / Scip , Krox 20 / Egr 2 and Sox 10

J. Svaren, D. Meijer, 2010 .

Differential regulation of NAB corepressor genes in Schwann cells

J. Svaren, T. Ezashi, R. Srinivasan, 2007, BMC Molecular Biology.

Interactions of Sox10 and Egr2 in myelin gene regulation.

R. Nagarajan, Li-Wei Chang, J. Svaren, 2007, Neuron glia biology.

Neuropathy-Associated Egr2 Mutants Disrupt Cooperative Activation of Myelin Protein Zero by Egr2 and Sox10

J. Svaren, S. Leblanc, R. Ward, 2007, Molecular and Cellular Biology.

In vivo detection of Egr2 binding to target genes during peripheral nerve myelination

J. Svaren, A. Roopra, L. Wrabetz, 2006, Journal of neurochemistry.

NAB2 Represses Transcription by Interacting with the CHD4 Subunit of the Nucleosome Remodeling and Deacetylase (NuRD) Complex*

Joshua Mayer, J. Svaren, R. Srinivasan, 2006, Journal of Biological Chemistry.

Regulation of cholesterol/lipid biosynthetic genes by Egr2/Krox20 during peripheral nerve myelination

J. Svaren, L. Wrabetz, R. Srinivasan, 2005, Journal of neurochemistry.

The Ddx20/DP103 Dead Box Protein Represses Transcriptional Activation by Egr2/Krox-20*

J. Svaren, A. L. Gillian, 2004, Journal of Biological Chemistry.

Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation

G. Crawford, Lingyun Song, A. Prasad, 2016, BMC Genomics.

Differential Sox10 genomic occupancy in myelinating glia

S. Keleş, J. Svaren, B. Emery, 2015, Glia.

Haplotype-specific modulation of a SOX10/CREB response element at the Charcot-Marie-Tooth disease type 4C locus SH3TC2.

F. Baas, S. Züchner, G. Beecham, 2014, Human molecular genetics.

SOX10 regulates expression of the SH3-domain kinase binding protein 1 (Sh3kbp1) locus in Schwann cells via an alternative promoter

Seneca L. Bessling, A. McCallion, J. Svaren, 2012, Molecular and Cellular Neuroscience.

Adeno-associated virus gene therapy to the rescue for Charcot-Marie-Tooth disease type 4J.

J. Svaren, 2021, The Journal of clinical investigation.

Revisiting the pathogenic mechanism of the GJB1 5’ UTR c.-103C > T mutation causing CMTX1

J. Svaren, G. Nicholson, B. Grosz, 2021, neurogenetics.

The Nab2 and Stat6 genes share a common transcription termination region.

D. Gilbert, N. Jenkins, J. Milbrandt, 1997, Genomics.

A Loss of Insulin-like Growth Factor-2 Imprinting Is Modulated by CCCTC-binding Factor Down-regulation at Senescence in Human Epithelial Cells*

J. Svaren, S. Schwarze, Vivian X. Fu, 2004, Journal of Biological Chemistry.

EGR1 Target Genes in Prostate Carcinoma Cells Identified by Microarray Analysis*

Mark A. Watson, M. Watson, J. Milbrandt, 2000, The Journal of Biological Chemistry.

Functional Dissection of the Oct6 Schwann Cell Enhancer Reveals an Essential Role for Dimeric Sox10 Binding

W. Mandemakers, F. Grosveld, J. Svaren, 2011, The Journal of Neuroscience.

Induction of Myelin Protein Zero by Early Growth Response 2 through Upstream and Intragenic Elements*

J. Svaren, S. Jang, 2009, The Journal of Biological Chemistry.

Requirements for Chromatin Modulation and Transcription Activation by the Pho4 Acidic Activation Domain

S. Martin, J. Svaren, C. Goding, 1998, Molecular and Cellular Biology.

Impaired prostate tumorigenesis in Egr1-deficient mice

P. Humphrey, W. Catalona, Sheng-Kwei Song, 2001, Nature Medicine.

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers

S. Keleş, Y. Yu, Jian-Hua Luo, 2020, Clinical Epigenetics.

The homeodomain protein Pho2 and the basic-helix-loop-helix protein Pho4 bind DNA cooperatively at the yeast PHO5 promoter.

M. Münsterkötter, J. Svaren, W Hörz, 1996, Nucleic acids research.

The transactivation domain of Pho4 is required for nucleosome disruption at the PHO5 promoter.

J. Schmitz, J. Svaren, W. Hörz, 1994, The EMBO journal.

The Nucleosome Remodeling and Deacetylase Chromatin Remodeling (NuRD) Complex Is Required for Peripheral Nerve Myelination

J. Svaren, R. Kohnken, Holly A Hung, 2012, The Journal of Neuroscience.

The Transcriptional Corepressor NAB2 Inhibits NGF-induced Differentiation of PC12 Cells

J. Milbrandt, J. Svaren, N. Davidson, 1998, The Journal of cell biology.

Use of real-time reverse transcriptase polymerase chain reaction assay and cell culture methods for detection of swine influenza A viruses.

J. Svaren, A. Karasin, C. Olsen, 2005, American journal of veterinary research.

differentiative stimuli. Krox20, is induced by proliferative and NAB2, a corepressor of NGFI-A (Egr-1) and

J. Milbrandt, J. Svaren, D. Zimonjic, 2013 .

Dual specificity phosphatase 15 regulates Erk activation in Schwann cells

J. Svaren, M. Weider, Katharina N Muth, 2017, Journal of neurochemistry.

Genome-Edited Coincidence and PMP22-HiBiT Fusion Reporter Cell Lines Enable an Artifact-Suppressive Quantitative High-Throughput Screening Strategy for PMP22 Gene-Dosage Disorder Drug Discovery.

A. Dutra, James Inglese, J. Svaren, 2021, ACS pharmacology & translational science.

Regulation of the PMP22 Gene through an Intronic Enhancer

R. Nagarajan, Li-Wei Chang, J. Svaren, 2011, The Journal of Neuroscience.

The transcriptional corepressor NAB2 blocks Egr-1-mediated growth factor activation and angiogenesis.

M. Braddock, J. Milbrandt, J. Svaren, 2001, Biochemical and biophysical research communications.

[8] In Vivo Analysis of nucleosome structure and transcription factor binding in Saccharomyces cerevisiae

U. Venter, J. Svaren, W. Hörz, 1995 .

Cbl-b Regulates Antigen-Induced TCR Down-Regulation and IFN-γ Production by Effector CD8 T Cells without Affecting Functional Avidity1

J. Svaren, M. Suresh, S. Nanjappa, 2007, The Journal of Immunology.

Functional Avidity Effector CD8 T Cells without Affecting Production by g Down-Regulation and IFN-Cbl-b Regulates Antigen-Induced TCR

J. Svaren, M. Suresh, S. Nanjappa, 2007 .

MicroRNAs as Biomarkers of Charcot-Marie-Tooth Disease Type 1A

J. Svaren, K. Call, Xingyao Wu, 2021, Neurology.

The Transcriptional Corepressor NAB 2 Inhibits NGF-induced Differentiation of PC 12 Cells

J. Milbrandt, J. Svaren, N. Davidson, 1998 .

ACTL6a coordinates axonal caliber recognition and myelination in the peripheral nerve

G. Crabtree, J. Svaren, John J. Moran, 2022, iScience.

Comparison of Nucleosome Remodeling by the Yeast Transcription Factor Pho4 and the Glucocorticoid Receptor*

Florian Then Bergh, J. Svaren, F. Bergh, 2000, The Journal of Biological Chemistry.

Identification of drug modulators targeting gene-dosage disease CMT1A.

James Inglese, J. Svaren, R. Macarthur, 2012, ACS chemical biology.

Modulation of monocyte signaling and pore formation in response to agonists of the nucleotide receptor P2X7

J. Svaren, P. Bertics, M. Suresh, 2002, Journal of leukocyte biology.

A mutation in the Tubb4a gene leads to microtubule accumulation with hypomyelination and demyelination

I. Duncan, J. Svaren, John J. Moran, 2017, Annals of neurology.

HDAC-mediated Deacetylation of NF-κB is Critical for Schwann cell Myelination

K. Nave, E. Olson, J. Svaren, 2011, Nature Neuroscience.

Epigenetic susceptibility factors for prostate cancer with aging

J. Svaren, D. Jarrard, S. Bhusari, 2013, The Prostate.

Associations Between Early Life Stress and Gene Methylation in Children

S. Pollak, J. Svaren, Sarah E. Romens, 2014, Child development.

Regulation of Memory CD8 T-Cell Differentiation by Cyclin-Dependent Kinase Inhibitor p27Kip1

J. Svaren, R. Srinivasan, M. Suresh, 2010, Molecular and Cellular Biology.

A novel mouse model of CMT1B identifies hyperglycosylation as a new pathogenetic mechanism

J. Svaren, A. Schenone, L. Nobbio, 2022, Human molecular genetics.

Neuregulin 1 type III reduces severity in a mouse model of Congenital Hypomyelinating Neuropathy

K. Nave, J. Svaren, L. Wrabetz, 2018, bioRxiv.

Role of cell cycle regulator E2F1 in regulating CD8 T cell responses during acute and chronic viral infection.

J. Svaren, M. Suresh, K. Tewari, 2004, Virology.

Modifier Gene Candidates in Charcot-Marie-Tooth Disease Type 1A: A Case-Only Genome-Wide Association Study

F. Baas, S. Züchner, G. Beecham, 2019, Journal of neuromuscular diseases.

A mutation in the canine gene encoding folliculin‐interacting protein 2 (FNIP2) associated with a unique disruption in spinal cord myelination

T. Pemberton, P. Patel, I. Duncan, 2014, Glia.

CTCF loss mediates unique DNA hypermethylation landscapes in human cancers

S. Keleş, Y. Yu, Jian-Hua Luo, 2020, Clinical Epigenetics.

Stringent comparative sequence analysis reveals SOX10 as a putative inhibitor of glial cell differentiation

J. Mullikin, G. Crawford, Lingyun Song, 2016, BMC Genomics.

Epigenomic reprogramming in peripheral nerve injury

J. Svaren, Ki H. Ma, 2016, Neural regeneration research.