S. L. Le Grice

发表

Correlating SHAPE signatures with three-dimensional RNA structures.

B. Shapiro, E. Bindewald, M. Wendeler, 2011, RNA.

Functional interactions of nucleocapsid protein of feline immunodeficiency virus and cellular prion protein with the viral RNA.

S. L. Le Grice, M. Moscardini, M. Pistello, 2002, Journal of molecular biology.

The RNA Transport Element of the Murine musD Retrotransposon Requires Long-range Intramolecular Interactions for Function*

Katarzyna J Purzycka, K. Purzycka, M. Legiewicz, 2010, The Journal of Biological Chemistry.

Using pyrrolo-deoxycytosine to probe RNA/DNA hybrids containing the human immunodeficiency virus type-1 3' polypurine tract.

S. L. Le Grice, C. Dash, J. Rausch, 2004, Nucleic acids research.

RNA secondary structure prediction using high-throughput SHAPE.

Katarzyna J Purzycka, K. Purzycka, S. L. Le Grice, 2013, Journal of visualized experiments : JoVE.

Two-dimensional crystallization of histidine-tagged, HIV-1 reverse transcriptase promoted by a novel nickel-chelating lipid.

P. Brown, S. L. Le Grice, E. Kubalek, 1994, Journal of structural biology.

Viral Reverse Transcriptases Show Selective High Affinity Binding to DNA-DNA Primer-Templates that Resemble the Polypurine Tract

J. DeStefano, S. L. Le Grice, C. Dash, 2012, PloS one.

Characterization of (+) strand initiation and termination sequences located at the center of the equine infectious anemia virus genome.

M. Waring, S. L. Le Grice, L. Boone, 1999, Biochemistry.

Analogs of cyclic AMP that elicit the biochemically defined conformational change in catabolite gene activator protein (CAP) but do not stimulate binding to DNA.

R. Ebright, S. L. Le Grice, J. Krakow, 1985, Journal of molecular biology.

Subregions of a conserved part of the HIV gp41 transmembrane protein are differentially recognized by antibodies of infected individuals.

H. Bujard, U. Certa, R. Gentz, 1986, The EMBO journal.

Kinetic Analysis of Four HIV-1 Reverse Transcriptase Enzymes Mutated in the Primer Grip Region of p66

S. Thrall, R. Goody, S. L. Le Grice, 1997, The Journal of Biological Chemistry.

Development of Small Molecules with a Noncanonical Binding Mode to HIV-1 Trans Activation Response (TAR) RNA.

G. Varani, S. L. Le Grice, Joanna Sztuba-Solinska, 2016, Journal of medicinal chemistry.

Two Modes of HIV-1 Polypurine Tract Cleavage Are Affected by Introducing Locked Nucleic Acid Analogs into the (-) DNA Template*

S. L. Le Grice, C. Dash, H. Yi-Brunozzi, 2004, Journal of Biological Chemistry.

Mutating Conserved Residues in the Ribonuclease H Domain of Ty3 Reverse Transcriptase Affects Specialized Cleavage Events*

S. L. Le Grice, D. Lener, S. Budihas, 2002, The Journal of Biological Chemistry.

Hydroxylated Tropolones Inhibit Hepatitis B Virus Replication by Blocking Viral Ribonuclease H Activity

J. Tavis, S. L. Le Grice, Craig J. Thomas, 2014, Antimicrobial Agents and Chemotherapy.

Examining the Role of the HIV-1 Reverse Transcriptase p51 Subunit in Positioning and Hydrolysis of RNA/DNA Hybrids*

Wei Yang, S. L. Le Grice, Jennifer T. Miller, 2013, The Journal of Biological Chemistry.

Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

Wei Yang, S. L. Le Grice, Jennifer T. Miller, 2013, Nature Structural &Molecular Biology.

Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant

S. L. Le Grice, F. Fuller, S. Payne, 1993, Journal of virology.

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R

Patrick D. Dummer, C. Winkler, S. Hewitt, 2018, Communications Biology.

Synthetic α-Hydroxytropolones as Inhibitors of HIV Reverse Transcriptase Ribonuclease H Activity.

E. Gallicchio, S. L. Le Grice, J. Beutler, 2016, MedChemComm.

Probing anomalous structural features in polypurine tract-containing RNA-DNA hybrids with neomycin B.

Robert G. Brinson, Kevin B. Turner, S. L. Le Grice, 2009, Biochemistry.

3,7-Dihydroxytropolones Inhibit Initiation of Hepatitis B Virus Minus-Strand DNA Synthesis

E. Gallicchio, J. Tavis, S. L. Le Grice, 2020, Molecules.

What is the orientation of DNA polymerases on their templates?

S. Hughes, E. Arnold, S. L. Le Grice, 1996, Journal of virology.

Molecular recognition of HIV-1 RNAs with branched peptides.

S. L. Le Grice, W. Santos, Chringma Sherpa, 2019, Methods in enzymology.

Alanine-scanning Mutations in the “Primer Grip” of p66 HIV-1 Reverse Transcriptase Result in Selective Loss of RNA Priming Activity*

S. L. Le Grice, J. G. Levin, M. Ghosh, 1997, The Journal of Biological Chemistry.

Binding and kinetic properties of HIV‐1 reverse transcriptase markedly differ during initiation and elongation of reverse transcription.

C. Ehresmann, S. L. Le Grice, B. Ehresmann, 1996, The EMBO journal.

Broad anti-herpesviral activity of α-hydroxytropolones.

S. L. Le Grice, L. Morrison, J. Baines, 2018, Veterinary microbiology.

Identification of specific HIV-1 reverse transcriptase contacts to the viral RNA:tRNA complex by mass spectrometry and a primary amine selective reagent

L. Pannell, S. L. Le Grice, Jennifer T. Miller, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Dissecting APOBEC3G Substrate Specificity by Nucleoside Analog Interference*

S. L. Le Grice, M. Goodman, J. Rausch, 2009, Journal of Biological Chemistry.

A capillary electrophoretic assay for ribonuclease H activity.

S. L. Le Grice, J. Mcmahon, R. Crouch, 2004, Analytical biochemistry.

A fluorescence-based high-throughput screening assay for inhibitors of human immunodeficiency virus-1 reverse transcriptase-associated ribonuclease H activity.

S. L. Le Grice, M. Parniak, J. Beutler, 2003, Analytical biochemistry.

Synthetic tRNALys,3 as the replication primer for the HIV-1HXB2 and HIV-1Mal genomes.

S. Scaringe, A. Khvorova, S. L. Le Grice, 2004, Nucleic acids research.

Solid-Phase Synthesis of 5'-O-β,γ-Methylenetriphosphate Derivatives of Nucleosides and Evaluation of Their Inhibitory Activity Against HIV-1 Reverse Transcriptase.

K. Parang, S. L. Le Grice, Y. Ahmadibeni, 2010, Tetrahedron letters.

Probing the Structures of Viral RNA Regulatory Elements with SHAPE and Related Methodologies

S. L. Le Grice, Joanna Sztuba-Solinska, J. Rausch, 2018, Front. Microbiol..

Examining Interactions of HIV-1 Reverse Transcriptase with Single-stranded Template Nucleotides by Nucleoside Analog Interference*

S. L. Le Grice, V. Prasad, T. Fisher, 2006, Journal of Biological Chemistry.

HIV‐1 RT‐associated ribonuclease H displays both endonuclease and 3′‐‐‐‐5′ exonuclease activity.

S. L. Le Grice, J. Mous, S. F. Grice, 1990, The EMBO journal.

An expanded model of replicating human immunodeficiency virus reverse transcriptase.

E. Arnold, S. L. Le Grice, C. Tantillo, 1995, Biochemistry.

Modulation of HIV-1 reverse transcriptase function in "selectively deleted" p66/p51 heterodimers.

S. L. Le Grice, P. Jacques, B. Wöhrl, 1994, The Journal of biological chemistry.

Analysis of the interactions of HIV1 replication primer tRNA(Lys,3) with nucleocapsid protein and reverse transcriptase.

S. L. Le Grice, J. Darlix, C. Barat, 1993, Journal of molecular biology.

Interaction of tRNA(Lys-3) with multiple forms of human immunodeficiency virus reverse transcriptase.

S. L. Le Grice, B. Wöhrl, N. J. Richter-Cook, 1992, The Journal of biological chemistry.

Reconstitution and properties of homologous and chimeric HIV-1.HIV-2 p66.p51 reverse transcriptase.

S. L. Le Grice, K. Frank, I. Sim, 1991, The Journal of biological chemistry.

A single 66-kilodalton polypeptide processed from the human immunodeficiency virus type 2 pol polyprotein in Escherichia coli displays reverse transcriptase activity

S. L. Le Grice, J. Mous, R. Zehnle, 1988, Journal of virology.

Purification and characterization of human immunodeficiency virus type 1 reverse transcriptase.

C. Cameron, S. Benkovic, S. L. Le Grice, 1995, Methods in enzymology.

Human Immunodeficiency Virus Type 2 Reverse Transcriptase Activity in Model Systems That Mimic Steps in Reverse Transcription

S. L. Le Grice, Jennifer T. Miller, A. Hizi, 2003, Journal of Virology.

Biosynthesis and analysis of a genetically engineered HIV-1 reverse transcriptase/endonuclease polyprotein in Escherichia coli.

S. L. Le Grice, A. Leuthardt, 1988, Gene.

Expression of biologically active human T-cell lymphotropic virus type III reverse transcriptase in Bacillus subtilis.

S. L. Le Grice, J. Mous, V. Beuck, 1987, Gene.

Reverse Transcription in the Saccharomyces cerevisiae Long-Terminal Repeat Retrotransposon Ty3

S. L. Le Grice, Jennifer T. Miller, J. Rausch, 2017, Viruses.

Active site and allosteric inhibitors of the ribonuclease H activity of HIV reverse transcriptase.

S. L. Le Grice, E. Tramontano, A. Corona, 2013, Future medicinal chemistry.

Examining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybrids

S. L. Le Grice, M. Götte, C. Dash, 2008, Nucleic acids research.

Exploiting structurally diverse nucleoside analogs as probes of reverse transcription complexes.

S. L. Le Grice, J. Rausch, 2007, Current HIV research.

Probing Contacts between the Ribonuclease H Domain of HIV-1 Reverse Transcriptase and Nucleic Acid by Site-specific Photocross-linking*

B. Sathyanarayana, S. L. Le Grice, Marion K. Bona, 2000, The Journal of Biological Chemistry.

Interaction of p55 Reverse Transcriptase from theSaccharomyces cerevisiae Retrotransposon Ty3 with Conformationally Distinct Nucleic Acid Duplexes*

S. L. Le Grice, Jennifer T. Miller, J. Rausch, 2000, The Journal of Biological Chemistry.

Footprint analysis of replicating murine leukemia virus reverse transcriptase.

A. Telesnitsky, W. Hendrickson, S. L. Le Grice, 1995, Science.

Insights into secondary and tertiary interactions of dengue virus RNA by SHAPE.

S. L. Le Grice, Joanna Sztuba-Solinska, 2014, Methods in molecular biology.

Synthesis of nucleoside 5'-O-alpha,beta-methylene-beta-triphosphates and evaluation of their potency towards inhibition of HIV-1 reverse transcriptase.

H. Agarwal, K. Parang, S. L. Le Grice, 2010, Organic & biomolecular chemistry.

HIV-1 reverse transcriptase interaction with model RNA-DNA duplexes.

S. L. Le Grice, I. Gorshkova, R. Crouch, 2001, Analytical biochemistry.

Madurahydroxylactone Derivatives as Dual Inhibitors of Human Immunodeficiency Virus Type 1 Integrase and RNase H

Y. Pommier, J. Mellors, S. L. Le Grice, 2007, Antimicrobial Agents and Chemotherapy.

Redesignation of the RNase D activity associated with retroviral reverse transcriptase as RNase H

S. Hughes, S. Goff, S. L. Le Grice, 1994, Journal of virology.

Selective inhibition of HIV-1 reverse transcriptase-associated ribonuclease H activity by hydroxylated tropolones

S. L. Le Grice, J. Mcmahon, I. Gorshkova, 2005, Nucleic acids research.

Attenuation of DNA replication by HIV-1 reverse transcriptase near the central termination sequence.

S. L. Le Grice, M. Barkley, A. Berdis, 2005, Biochemistry.

Interaction of Bacillus subtilis RNA polymerase with a chromosomal promoter.

S. L. Le Grice, A. Sonenshein, 1982, Journal of molecular biology.

Applying Thymine Isostere 2,4-Difluoro-5-Methylbenzene as a NMR Assignment Tool and Probe of Homopyrimidine/Homopurine Tract Structural Dynamics.

Robert G. Brinson, J. Kahn, S. L. Le Grice, 2016, Methods in enzymology.

Isolation by differential and zonal centrifugation of minicells segregated by Escherichia coli.

S. L. Le Grice, D. Jackson, G. R. Barker, 1979, Journal of general microbiology.

Examining Ty3 Polypurine Tract Structure and Function by Nucleoside Analog Interference*

S. L. Le Grice, C. Dash, J. Marino, 2006, Journal of Biological Chemistry.

New monoterpene glycosides and phenolic compounds from Distylium racemosum and their inhibitory activity against ribonuclease H.

S. L. Le Grice, J. Mcmahon, Jeong Ah Kim, 2011, Bioorganic & medicinal chemistry letters.

HIV-1 reverse transcriptase can simultaneously engage its DNA/RNA substrate at both DNA polymerase and RNase H active sites: implications for RNase H inhibition.

M. Wendeler, S. L. Le Grice, G. Beilhartz, 2009, Journal of molecular biology.

HIV-1 ribonuclease H inhibitory phenolic glycosides from Eugenia hyemalis.

S. L. Le Grice, J. Mcmahon, J. Beutler, 2008, Journal of natural products.

Evaluation of retroviral ribonuclease H activity.

S. L. Le Grice, J. Miller, J. Rausch, 2001, Methods in molecular biology.

Intrinsic DNA synthesis fidelity of xenotropic murine leukemia virus‐related virus reverse transcriptase

S. L. Le Grice, L. Menéndez-Arias, Yi Wang, 2012, The FEBS journal.

Multiple Sources of Contamination in Samples from Patients Reported to Have XMRV Infection

S. Hughes, J. Mellors, J. Coffin, 2012, PloS one.

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples

W. Linehan, C. Vocke, V. Pathak, 2011, Advances in virology.

Inhibition of multi-drug resistant HIV-1 reverse transcriptase by nucleoside β-triphosphates.

K. Parang, S. L. Le Grice, Y. Ahmadibeni, 2011, Bioorganic & medicinal chemistry letters.

Hydrolysis of RNA/DNA hybrids containing nonpolar pyrimidine isosteres defines regions essential for HIV type 1 polypurine tract selection

S. L. Le Grice, E. Kool, J. Rausch, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Nonpolar Thymine Isosteres in the Ty3 Polypurine Tract DNA Template Modulate Processing and Provide a Model for Its Recognition by Ty3 Reverse Transcriptase*

S. L. Le Grice, M. Kvaratskhelia, D. Lener, 2003, Journal of Biological Chemistry.

Characterization of the C-Terminal Nuclease Domain of Herpes Simplex Virus pUL15 as a Target of Nucleotidyltransferase Inhibitors.

L. Tang, S. L. Le Grice, J. Baines, 2016, Biochemistry.

SiRNA-Induced Mutation in HIV-1 Polypurine Tract Region and Its Influence on Viral Fitness

Kendall C. Krebs, Chuanwu Zhu, Yong Gao, 2015, PloS one.

Probing Retroviral and Retrotransposon Genome Structures: The “SHAPE” of Things to Come

S. L. Le Grice, Joanna Sztuba-Solinska, 2012, Molecular biology international.

Reverse transcriptase in motion: conformational dynamics of enzyme-substrate interactions.

S. Sarafianos, S. L. Le Grice, B. Marchand, 2010, Biochimica et biophysica acta.

Revisiting Plus-Strand DNA Synthesis in Retroviruses and Long Terminal Repeat Retrotransposons: Dynamics of Enzyme: Substrate Interactions

S. L. Le Grice, D. Fabris, J. Marino, 2009, Viruses.

SHAMS: combining chemical modification of RNA with mass spectrometry to examine polypurine tract-containing RNA/DNA hybrids.

Robert G. Brinson, Kevin B. Turner, S. L. Le Grice, 2009, RNA.

Structural probing of the HIV-1 polypurine tract RNA:DNA hybrid using classic nucleic acid ligands

Robert G. Brinson, Kevin B. Turner, S. L. Le Grice, 2008, Nucleic acids research.

High-resolution NMR analysis of the conformations of native and base analog substituted retroviral and LTR-retrotransposon PPT primers.

Robert G. Brinson, S. L. Le Grice, J. Marino, 2008, Chemistry & biology.

Purine analog substitution of the HIV-1 polypurine tract primer defines regions controlling initiation of plus-strand DNA synthesis

S. L. Le Grice, J. Rausch, 2006, Nucleic acids research.

Investigating HIV-1 Polypurine Tract Geometry via Targeted Insertion of Abasic Lesions in the (–)-DNA Template and (+)-RNA Primer*

S. L. Le Grice, H. Yi-Brunozzi, 2005, Journal of Biological Chemistry.

'Binding, bending and bonding': polypurine tract-primed initiation of plus-strand DNA synthesis in human immunodeficiency virus.

S. L. Le Grice, J. Rausch, 2004, The international journal of biochemistry & cell biology.

Pre-existing Distortions in Nucleic Acid Structure Aid Polypurine Tract Selection by HIV-1 Reverse Transcriptase*

S. L. Le Grice, M. Kvaratskhelia, S. Budihas, 2002, The Journal of Biological Chemistry.

Altering the RNase H primer grip of human immunodeficiency virus reverse transcriptase modifies cleavage specificity.

S. Hughes, S. L. Le Grice, Jennifer T. Miller, 2002, Biochemistry.

Residues in the αH and αI Helices of the HIV-1 Reverse Transcriptase Thumb Subdomain Required for the Specificity of RNase H-catalyzed Removal of the Polypurine Tract Primer*

Samuel H. Wilson, T. Darden, T. Kunkel, 1999, The Journal of Biological Chemistry.

Substituting a Conserved Residue of the Ribonuclease H Domain Alters Substrate Hydrolysis by Retroviral Reverse Transcriptase*

S. L. Le Grice, J. Rausch, Stuart F. J. Le Grice, 1997, The Journal of Biological Chemistry.

N-Substituted Quinolinonyl Diketo Acid Derivatives as HIV Integrase Strand Transfer Inhibitors and Their Activity against RNase H Function of Reverse Transcriptase.

Y. Pommier, E. Novellino, S. L. Le Grice, 2015, Journal of medicinal chemistry.

Divalent cation modulation of the ribonuclease functions of human immunodeficiency virus reverse transcriptase.

C. Cameron, S. Benkovic, S. L. Le Grice, 1995, Biochemistry.

Rapid purification of homodimer and heterodimer HIV-1 reverse transcriptase by metal chelate affinity chromatography.

S. L. Le Grice, S. F. Grice, F. Grüninger-Leitch, 1990, European journal of biochemistry.

An Evolved RNA Recognition Motif That Suppresses HIV-1 Tat/TAR-Dependent Transcription.

S. L. Le Grice, I. Laird-Offringa, Brian R. McNaughton, 2016, ACS chemical biology.

Traceless Solid-Phase α-Hydroxytropolone Synthesis.

S. L. Le Grice, J. Beutler, Jennifer A. Wilson, 2016, MedChemComm.

Two distinct modes of metal ion binding in the nuclease active site of a viral DNA-packaging terminase: insight into the two-metal-ion catalytic mechanism

L. Tang, S. L. Le Grice, Haiyan Zhao, 2015, Nucleic acids research.

Scaffold hopping and optimisation of 3’,4’-dihydroxyphenyl- containing thienopyrimidinones: synthesis of quinazolinone derivatives as novel allosteric inhibitors of HIV-1 reverse transcriptase-associated ribonuclease H

P. Caboni, S. L. Le Grice, J. Beutler, 2020, Journal of enzyme inhibition and medicinal chemistry.

Synthesis and biological assessment of 3,7-dihydroxytropolones.

E. Gallicchio, J. Tavis, S. L. Le Grice, 2017, Organic & biomolecular chemistry.

Ribonuclease H/DNA Polymerase HIV-1 Reverse Transcriptase Dual Inhibitor: Mechanistic Studies on the Allosteric Mode of Action of Isatin-Based Compound RMNC6

S. L. Le Grice, L. Menéndez-Arias, E. Tramontano, 2016, PloS one.

Basic Quinolinonyl Diketo Acid Derivatives as Inhibitors of HIV Integrase and their Activity against RNase H Function of Reverse Transcriptase

Y. Pommier, E. Novellino, S. L. Le Grice, 2014, Journal of medicinal chemistry.

Exploiting drug-resistant enzymes as tools to identify thienopyrimidinone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

P. Caboni, S. L. Le Grice, J. Beutler, 2013, Journal of medicinal chemistry.

Synthesis, activity, and structural analysis of novel α-hydroxytropolone inhibitors of human immunodeficiency virus reverse transcriptase-associated ribonuclease H.

E. Arnold, S. L. Le Grice, D. Himmel, 2011, Journal of medicinal chemistry.

Vinylogous ureas as a novel class of inhibitors of reverse transcriptase-associated ribonuclease H activity.

M. Wendeler, S. L. Le Grice, Jennifer T. Miller, 2008, ACS chemical biology.

Sensitivity of the C-Terminal Nuclease Domain of Kaposi's Sarcoma-Associated Herpesvirus ORF29 to Two Classes of Active-Site Ligands

L. Tang, S. L. Le Grice, Jennifer T. Miller, 2018, Antimicrobial Agents and Chemotherapy.

HIV‐1 reverse transcriptase‐associated RNase H cleaves RNA/RNA in arrested complexes: implications for the mechanism by which RNase H discriminates between RNA/RNA and RNA/DNA.

H. Gross, S. L. Le Grice, H. Heumann, 1995, The EMBO journal.

Nucleotide Excision Repair and Template-independent Addition by HIV-1 Reverse Transcriptase in the Presence of Nucleocapsid Protein*

A. Bibiłło, R. Gorelick, M. Wendeler, 2006, Journal of Biological Chemistry.

Inhibition of the initiation of HIV-1 reverse transcription by 3'-azido-3'-deoxythymidine. Comparison with elongation.

C. Ehresmann, S. L. Le Grice, B. Ehresmann, 2000, The Journal of biological chemistry.

Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates tryptophan-229 in template-primer utilization.

S. L. Le Grice, J. Darlix, M. Ottmann, 1994, The Journal of biological chemistry.

DNA binding proteins explore multiple local configurations during docking via rapid rebinding

S. L. Le Grice, E. Abbondanzieri, M. Ganji, 2016, Nucleic acids research.

Initiation complex dynamics direct the transitions between distinct phases of early HIV reverse transcription

X. Zhuang, S. L. Le Grice, Jennifer T. Miller, 2010, Nature Structural &Molecular Biology.

Functional roles of carboxylate residues comprising the DNA polymerase active site triad of Ty3 reverse transcriptase

George J. Klarmann, A. Bibiłło, G. Klarmann, 2005, Nucleic acids research.

Site- and subunit-specific incorporation of unnatural amino acids into HIV-1 reverse transcriptase.

G. Klarmann, S. L. Le Grice, S. Hecht, 2004, Protein expression and purification.

Direct and Indirect Contributions of RNA Secondary Structure Elements to the Initiation of HIV-1 Reverse Transcription*

C. Ehresmann, S. L. Le Grice, B. Ehresmann, 2002, The Journal of Biological Chemistry.

Characterization of Active Reverse Transcriptase and Nucleoprotein Complexes of the Yeast Retrotransposon Ty3 in Vitro *

S. L. Le Grice, D. Ficheux, C. Gabus, 1999, The Journal of Biological Chemistry.

Alternative modes of polymerization distinguish the subunits of equine infectious anemia virus reverse transcriptase.

S. L. Le Grice, P. Jacques, B. Wöhrl, 1994, The Journal of biological chemistry.

Domain structure of the human immunodeficiency virus reverse transcriptase.

S. L. Le Grice, H. Heumann, R. May, 1992, The EMBO journal.

Purification and characterization of recombinant equine infectious anemia virus reverse transcriptase

S. L. Le Grice, J. Darlix, G. Keith, 1991, Journal of virology.

Subunit‐selective mutagenesis indicates minimal polymerase activity in heterodimer‐associated p51 HIV‐1 reverse transcriptase.

T. Naas, S. L. Le Grice, S F Le Grice, 1991, The EMBO journal.

Interaction of HIV-1 reverse transcriptase with a synthetic form of its replication primer, tRNA(Lys,3).

S. L. Le Grice, J. Darlix, S. F. Grice, 1991, Nucleic acids research.

Interaction of retroviral reverse transcriptase with template-primer duplexes during replication.

E. Arts, S. L. Le Grice, 1998, Progress in nucleic acid research and molecular biology.

Specific initiation and switch to elongation of human immunodeficiency virus type 1 reverse transcription require the post‐transcriptional modifications of primer tRNA3Lys.

C. Ehresmann, C. Isel, S. L. Le Grice, 1996, The EMBO journal.

Identification of an inhibitor-binding site to HIV-1 integrase with affinity acetylation and mass spectrometry.

Robert Craigie, Sonja Hess, S. L. Le Grice, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Targeting the HIV RNA Genome: High-Hanging Fruit Only Needs a Longer Ladder

S. L. Le Grice, 2015, Current topics in microbiology and immunology.

Structural insights of the conserved “priming loop” of hepatitis B virus pre-genomic RNA

B. Shapiro, J. Ivanic, S. L. Le Grice, 2021, Journal of biomolecular structure & dynamics.

Effects of 3'-deoxynucleoside 5'-triphosphate concentrations on chain termination by nucleoside analogs during human immunodeficiency virus type 1 reverse transcription of minus-strand strong-stop DNA

M. Wainberg, E. Arts, S. L. Le Grice, 1996, Journal of virology.

Involvement of HIV-I Nucleocapsid Protein in the Recruitment of Reverse Transcriptase into Nucleoprotein Complexes Formedin Vitro*

B. Roques, S. L. Le Grice, J. Darlix, 1998, The Journal of Biological Chemistry.

Dynamics of the HIV-1 Reverse Transcription Complex during Initiation of DNA Synthesis*

C. Ehresmann, C. Isel, S. L. Le Grice, 2000, The Journal of Biological Chemistry.

Contacts between Reverse Transcriptase and the Primer Strand Govern the Transition from Initiation to Elongation of HIV-1 Reverse Transcription*

C. Ehresmann, S. L. Le Grice, B. Ehresmann, 1998, The Journal of Biological Chemistry.

Mutations in the Primer Grip of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Impair Proviral DNA Synthesis and Virion Maturation

C. Péchoux, S. L. Le Grice, J. Darlix, 1998, Journal of Virology.

Alterations to the primer grip of p66 HIV-1 reverse transcriptase and their consequences for template-primer utilization.

S. L. Le Grice, J. Darlix, D. Rodgers, 1996, Biochemistry.

Mutations M184V and Y115F in HIV-1 Reverse Transcriptase Discriminate against “Nucleotide-competing Reverse Transcriptase Inhibitors”*

S. L. Le Grice, D. Jochmans, E. Tchesnokov, 2008, Journal of Biological Chemistry.

Human Immunodeficiency Virus Reverse Transcriptase: 25 Years of Research, Drug Discovery, and Promise*

S. L. Le Grice, 2012, The Journal of Biological Chemistry.

Analysis of HIV-1 replication block due to substitutions at F61 residue of reverse transcriptase reveals additional defects involving the RNase H function

S. L. Le Grice, V. Prasad, C. Dash, 2006, Nucleic acids research.

Interaction of the Ty3 Reverse Transcriptase Thumb Subdomain with Template-Primer*

A. Bibiłło, S. L. Le Grice, D. Lener, 2005, Journal of Biological Chemistry.

A novel cell-free protein synthesis system.

Dominic Esposito, J. Hartley, D. Esposito, 2004, Journal of biotechnology.

Structure-Activity Analysis of Vinylogous Urea Inhibitors of Human Immunodeficiency Virus-Encoded Ribonuclease H

X. Zhuang, M. Wendeler, S. L. Le Grice, 2010, Antimicrobial Agents and Chemotherapy.

Role of the Reverse Transcriptase, Nucleocapsid Protein, and Template Structure in the Two-step Transfer Mechanism in Retroviral Recombination*

B. Roques, R. Gorelick, S. L. Le Grice, 2003, Journal of Biological Chemistry.

Processing protease and reverse transcriptase from human immunodeficiency virus type I polyprotein in Escherichia coli

S. L. Le Grice, J. Mous, E. Heimer, 1988, Journal of virology.

Combining asymmetric 13C-labeling and isotopic filter/edit NOESY: a novel strategy for rapid and logical RNA resonance assignment

Bruce A. Johnson, S. L. Le Grice, Regan M. LeBlanc, 2017, Nucleic acids research.

Mutating a conserved motif of the HIV-1 reverse transcriptase palm subdomain alters primer utilization.

S. L. Le Grice, J. G. Levin, M. Ghosh, 1997, Biochemistry.

Point mutations in conserved amino acid residues within the C‐terminal domain of HIV‐1 reverse transcriptase specifically repress RNase H function

S. L. Le Grice, F. Cromme, F. Grüninger-Leitch, 1989, FEBS letters.

Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1.

D. Spector, S. L. Le Grice, Michael J. Yonkunas, 2019, ACS chemical biology.

The Exonuclease Activity of Herpes Simplex Virus 1 UL12 Is Required for Production of Viral DNA That Can Be Packaged To Produce Infectious Virus

R. Szczepaniak, S. L. Le Grice, S. Weller, 2017, Journal of Virology.

Global transcription in pluripotent embryonic stem cells.

Daniel J. Hoeppner, T. Misteli, K. Buetow, 2008, Cell stem cell.

Determinants of Genomic RNA Encapsidation in the Saccharomyces cerevisiae Long Terminal Repeat Retrotransposons Ty1 and Ty3

Katarzyna J Purzycka, Katarzyna Pachulska-Wieczorek, S. L. Le Grice, 2016, Viruses.

Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry

S. L. Le Grice, Jennifer T. Miller, E. Nowak, 2014, Nature Structural & Molecular Biology.

Ty3 reverse transcriptase complexed with an RNA-DNA hybrid shows structural and functional asymmetry

S. L. Le Grice, Jennifer T. Miller, E. Nowak, 2014, Nature Structural &Molecular Biology.

Ty3 reverse transcriptase complexed with an RNA/DNA hybrid shows structural and functional asymmetry

S. L. Le Grice, Jennifer T. Miller, E. Nowak, 2013, Retrovirology.

Interplay of primary sequence, position and secondary RNA structure determines alternative splicing of LMNA in a pre-mature aging syndrome.

T. Misteli, S. L. Le Grice, Asaf Shilo, 2019, Nucleic acids research.

Interplay of primary sequence and RNA secondary structure in determining 5′ splice site choice

T. Misteli, S. L. Le Grice, Asaf Shilo, 2018 .

Gammaretrovirus mRNA expression is mediated by a novel, bipartite post-transcriptional regulatory element

S. L. Le Grice, J. Bear, B. Felber, 2014, Nucleic acids research.

Structural and functional properties of the HIV-1 RNA-tRNA(Lys)3 primer complex annealed by the nucleocapsid protein: comparison with the heat-annealed complex.

M. Wainberg, C. Ehresmann, B. Roques, 2002, RNA.

Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication

S. L. Le Grice, Jennifer T. Miller, R. Clubb, 2015, Journal of Virology.

Mutations in the Primer Grip Region of HIV Reverse Transcriptase Can Increase Replication Fidelity*

S. L. Le Grice, R. Bambara, M. Wisniewski, 1999, The Journal of Biological Chemistry.

Comparison of the human immunodeficiency virus type 1 and 2 proteases by hybrid gene construction and trans-complementation.

S. L. Le Grice, J. Mous, J. Mills, 1989, The Journal of biological chemistry.

Active site mutagenesis of the AIDS virus protease and its alleviation by trans complementation.

S. L. Le Grice, J. Mous, J. Mills, 1988, The EMBO journal.

Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time

K. Anastos, S. L. Le Grice, D. Rekosh, 2019, Journal of Virology.

Evolution of the HIV-1 RRE during natural infection reveals key nucleotide changes that correlate with altered structure and increased activity over time

K. Anastos, S. L. Le Grice, D. Rekosh, 2018 .

Discovery of a Branched Peptide That Recognizes the Rev Response Element (RRE) RNA and Blocks HIV-1 Replication.

A. Frankel, S. L. Le Grice, W. Santos, 2018, Journal of medicinal chemistry.

The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication

S. L. Le Grice, D. Rekosh, M. Hammarskjold, 2015, Nucleic acids research.

Role of Post-transcriptional Modifications of Primer tRNALys,3 in the Fidelity and Efficacy of Plus Strand DNA Transfer during HIV-1 Reverse Transcription*

S. L. Le Grice, J. Darlix, S. Auxilien, 1999, The Journal of Biological Chemistry.

Effects of tRNA 3 Lys aminoacylation on the initiation of HIV-1 reverse transcription.

C. Ehresmann, S. L. Le Grice, B. Ehresmann, 2003, Biochimie.

A dimeric lactone from Ardisia japonica with inhibitory activity for HIV-1 and HIV-2 ribonuclease H.

S. L. Le Grice, J. Mcmahon, K. Bae, 2007, Journal of natural products.

Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors*

A. Engelman, S. L. Le Grice, Y. Koh, 2012, The Journal of Biological Chemistry.

Adeno-associated viral vector mediated expression of broadly-neutralizing antibodies against HIV - hitting a fast-moving target.

S. L. Le Grice, Chringma Sherpa, 2020, Current HIV research.

Characterizing the Latent HIV-1 Reservoir in Patients with Viremia Suppressed on cART: Progress, Challenges, and Opportunities

S. L. Le Grice, J. Rausch, Stuart F.J. Le Grice, 2019, Current HIV research.

Identification of Biologically Active, HIV TAR RNA-Binding Small Molecules Using Small Molecule Microarrays

S. L. Le Grice, Joanna Sztuba-Solinska, Peter C. Gareiss, 2014, Journal of the American Chemical Society.

Recent Advances in Targeting the HIV-1 Tat/TAR Complex.

S. L. Le Grice, Fardokht A. Abulwerdi, 2017, Current pharmaceutical design.

Efficient utilization of Escherichia coli transcriptional signals in Bacillus subtilis.

H. Bujard, R. Gentz, S. L. Le Grice, 1985, Journal of molecular biology.

Structural basis for the specificity of the initiation of HIV‐1 reverse transcription

E. Westhof, C. Ehresmann, C. Isel, 1999, The EMBO journal.

Binding of RNA polymerase and the catabolite gene activator protein within the cat promoter in Escherichia coli.

S. L. Le Grice, H. Matzura, 1981, Journal of molecular biology.

Regulated promoter for high-level expression of heterologous genes in Bacillus subtilis.

S. L. Le Grice, 1990, Methods in enzymology.

"In the beginning": initiation of minus strand DNA synthesis in retroviruses and LTR-containing retrotransposons.

S. L. Le Grice, 2003, Biochemistry.

A cis-acting element in retroviral genomic RNA links Gag-Pol ribosomal frameshifting to selective viral RNA encapsidation.

Katarzyna J Purzycka, Yong Gao, E. Arts, 2013, Cell host & microbe.

Nuclease footprinting of human immunodeficiency virus reverse transcriptase/tRNA(Lys-3) complexes.

S. L. Le Grice, B. Ehresmann, G. Keith, 1993, The Journal of biological chemistry.

Mutating a Region of HIV-1 Reverse Transcriptase Implicated in tRNALys-3 Binding and the Consequences for (−)-Strand DNA Synthesis*

E. Arts, S. L. Le Grice, Jennifer T. Miller, 1998, The Journal of Biological Chemistry.

Ty3 Integrase Is Required for Initiation of Reverse Transcription

S. L. Le Grice, J. Darlix, N. Beliakova-Bethell, 2002, Journal of Virology.

Hydroxyl radical footprint analysis of human immunodeficiency virus reverse transcriptase-template.primer complexes.

S. L. Le Grice, H. Heumann, W. Metzger, 1993, Proceedings of the National Academy of Sciences of the United States of America.

High prevalence of serum antibodies to equine infectious anemia virus reverse transcriptase.

S. L. Le Grice, C. Issel, R. Montelaro, 1993, AIDS research and human retroviruses.

Mutagenesis of Human Immunodeficiency Virus Reverse Transcriptase p51 Subunit Defines Residues Contributing to Vinylogous Urea Inhibition of Ribonuclease H Activity*

S. Hughes, S. L. Le Grice, Jennifer T. Miller, 2011, The Journal of Biological Chemistry.

Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein.

C. Cameron, S. Benkovic, S. L. Le Grice, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Immunodeficiency Virus Type 2 pol Polyprotein in Escherichia coli

S. L. Le Grice, J. Mous, R. Zehnle, 2022 .

A Novel Interaction of tRNALys,3 with the Feline Immunodeficiency Virus RNA Genome Governs Initiation of Minus Strand DNA Synthesis*

S. L. Le Grice, Jennifer T. Miller, B. Ehresmann, 2001, The Journal of Biological Chemistry.

Fluorimetric analysis of recombinant p15 HIV-1 ribonuclease H.

S. L. Le Grice, R. Kalayjian, N. Cirino, 1993, The Journal of biological chemistry.

Influence of RNA structural elements on Ty1 retrotransposition

Jef D. Boeke, Katarzyna J Purzycka, J. Boeke, 2013, Mobile genetic elements.

Kaposi's sarcoma-associated herpesvirus polyadenylated nuclear RNA: a structural scaffold for nuclear, cytoplasmic and viral proteins

S. L. Le Grice, Jennifer T. Miller, Joanna Sztuba-Solinska, 2017, Nucleic acids research.

In vitro evidence for the interaction of tRNA(3)(Lys) with U3 during the first strand transfer of HIV-1 reverse transcription.

C. Ehresmann, B. Roques, S. L. Le Grice, 2000, Nucleic acids research.

Advances in RNA structure determination.

B. Shapiro, S. L. Le Grice, 2016, Methods.

Mass Spectrometric Analysis of the HIV-1 Integrase-Pyridoxal 5′-Phosphate Complex Reveals a New Binding Site for a Nucleotide Inhibitor*

V. Pathak, S. L. Le Grice, M. Nicklaus, 2005, Journal of Biological Chemistry.

Molecular recognition of a branched peptide with HIV-1 Rev Response Element (RRE) RNA.

S. L. Le Grice, W. Santos, Chringma Sherpa, 2019, Bioorganic & medicinal chemistry.

HIV-1 Transmission by Dendritic Cell-specific ICAM-3-grabbing Nonintegrin (DC-SIGN) Is Regulated by Determinants in the Carbohydrate Recognition Domain That Are Absent in Liver/Lymph Node-SIGN (L-SIGN)*

S. L. Le Grice, V. KewalRamani, J. Rausch, 2009, The Journal of Biological Chemistry.

In-gel probing of individual RNA conformers within a mixed population reveals a dimerization structural switch in the HIV-1 leader

S. L. Le Grice, A. Lever, Liam J. Prestwood, 2013, Nucleic acids research.

SHAPE analysis of the FIV Leader RNA reveals a structural switch potentially controlling viral packaging and genome dimerization

M. Legiewicz, S. L. Le Grice, S. J. Tanner, 2011, Nucleic acids research.

Sesquiterpenoid tropolone glycosides from Liriosma ovata.

Jun Ma, S. L. Le Grice, J. Beutler, 2015, Journal of natural products.

Resistance to RevM10 inhibition reflects a conformational switch in the HIV-1 Rev response element

Kevin B. Turner, M. Legiewicz, S. L. Le Grice, 2008, Proceedings of the National Academy of Sciences.

APOL1 risk allele RNA contributes to renal toxicity by activating protein kinase R

Patrick D. Dummer, C. Winkler, S. Hewitt, 2018, Communications Biology.

The xenotropic murine leukemia virus-related retrovirus debate continues at first international workshop

R. Silverman, C. Boucher, S. L. Le Grice, 2010, Retrovirology.

Ty3 reverse transcriptase complexed with an RNA/DNA hybrid shows structural and functional asymmetry

S. L. Le Grice, Jennifer T. Miller, E. Nowak, 2013, Retrovirology.

Structural analysis of monomeric retroviral reverse transcriptase in complex with an RNA/DNA hybrid

J. Bujnicki, D. Svergun, S. L. Le Grice, 2013, Nucleic acids research.

A ribose sugar conformational switch in the LTR-retrotransposon Ty3 polypurine tract-containing RNA/DNA hybrid.

S. L. Le Grice, J. Marino, D. Lener, 2005, Journal of the American Chemical Society.

Mutations in the ribonuclease H active site of HIV-RT reveal a role for this site in stabilizing enzyme-primer-template binding.

J. DeStefano, S. L. Le Grice, J. Rausch, 2002, Biochemistry.

Mutating P2 and P1 residues at cleavage junctions in the HIV‐1 pol polyprotein Effects on hydrolysis by HIV‐1 proteinase

J. Kay, L. H. Phylip, S. L. Le Grice, 1991, FEBS letters.

HIV Rev Assembly on the Rev Response Element (RRE): A Structural Perspective

S. L. Le Grice, Stuart F. J. Le Grice, J. Rausch, 2015, Viruses.

Discovery of Small Molecules Targeting the Frameshifting Element RNA in SARS-CoV-2 Viral Genome.

A. Ferré-D’Amaré, S. L. Le Grice, Christopher P Jones, 2023, ACS medicinal chemistry letters.

HIV Genetic Diversity - Superpower of a Formidable Virus.

S. L. Le Grice, Chringma Sherpa, J. Rausch, 2020, Current HIV research.

Identifying and Characterizing a Functional HIV-1 Reverse Transcriptase-binding Site on Integrase*

M. Zhang, S. L. Le Grice, Jennifer T. Miller, 2009, Journal of Biological Chemistry.

The “complex” RNA post-transcriptional element of a “simple” retrovirus

Katarzyna J Purzycka, S. L. Le Grice, B. Felber, 2015, Mobile Genetic Elements.

Restoration of tRNA3Lys-primed(-)-strand DNA synthesis to an HIV-1 reverse transcriptase mutant with extended tRNAs. Implications for retroviral replication.

E. Arts, S. L. Le Grice, B. Ehresmann, 1996, The Journal of biological chemistry.

Primer selection by HIV-1 reverse transcriptase on RNA-tRNA(3Lys) and DNA-tRNA(3Lys) hybrids.

C. Ehresmann, S. L. Le Grice, M. Yusupov, 1996, Journal of molecular biology.

Structural complexity of Dengue virus untranslated regions: cis-acting RNA motifs and pseudoknot interactions modulating functionality of the viral genome

B. Shapiro, S. L. Le Grice, Joanna Sztuba-Solinska, 2013, Nucleic acids research.

Investigating the "steric gate" of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by targeted insertion of unnatural amino acids.

G. Klarmann, S. L. Le Grice, S. Hecht, 2007, Biochemistry.

Localisation of the transcription initiation site of the chloramphenicol resistance gene on plasmid pAC184

S. L. Le Grice, H. Matzura, 1980, FEBS letters.

Human Immunodeficiency Virus Reverse Transcriptase: 25 Years of Research, Drug Discovery, and Promise*

S. L. Le Grice, S. F. Grice, 2012, The Journal of Biological Chemistry.