S. Meakin

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The nerve growth factor family of receptors

E. Shooter, S. Meakin, 1992, Trends in Neurosciences.

Quantitative Tissue Ph Measurement during Cerebral Ischemia Using Amine and Amide Concentration-Independent Detection (AACID) with MRI

Robert Bartha, R. Bartha, S. Meakin, 2014, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Imaging chemical exchange saturation transfer (CEST) effects following tumor‐selective acidification using lonidamine

R. Bartha, S. Meakin, Alex X. Li, 2015, NMR in biomedicine.

Topiramate induces acute intracellular acidification in glioblastoma

R. Bartha, S. Meakin, Alex X. Li, 2016, Journal of Neuro-Oncology.

Nerve growth factor activation of the TrkA receptor induces cell death, by macropinocytosis, in medulloblastoma Daoy cells

S. Meakin, J. MacDonald, Chunhui Li, 2010, Journal of neurochemistry.

Deletions in the Extracellular Domain of Rat TrkA Lead to an Altered Differentiative Phenotype in Neurotrophin Responsive Cells

S. Meakin, J. MacDonald, 1996, Molecular and Cellular Neuroscience.

Distinct human NUMB isoforms regulate differentiation vs. proliferation in the neuronal lineage.

H. Lipshitz, S. Meakin, A. Bashirullah, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Nerve Growth Factor Receptor TrkA, a New Receptor in Insulin Signaling Pathway in PC12 Cells*

M. White, S. Meakin, T. Geetha, 2013, The Journal of Biological Chemistry.

Ectopic expression of the TrkA receptor in adult dopaminergic mesencephalic neurons promotes retrograde axonal NGF transport and NGF-dependent neuroprotection

B. Melchior, S. Meakin, P. Brachet, 2003, Experimental Neurology.

Aging effects of vitamin C on a human lens protein produced in vitro

L. Tsui, S. Meakin, D. Garland, 1987, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Structural and evolutionary relationships among five members of the human gamma-crystallin gene family

L. Tsui, S. Meakin, M. Breitman, 1985 .

Structural and evolutionary relationships among five members of the human gamma-crystallin gene family

L. Tsui, S. Meakin, M. Breitman, 1985, Molecular and cellular biology.

Gamma-crystallins of the human eye lens: expression analysis of five members of the gene family

L. Tsui, S. Meakin, M. Breitman, 1987, Molecular and cellular biology.

The signaling adapters fibroblast growth factor receptor substrate 2 and 3 are activated by the thyroid TRK oncoproteins.

M. Pierotti, S. Meakin, A. Greco, 2003, Endocrinology.

Ras Guanine Nucleotide Releasing Factor 1 (RasGrf1) Enhancement of Trk Receptor-Mediated Neurite Outgrowth Requires Activation of Both H-Ras and Rac

S. Meakin, J. MacDonald, A. Talebian, 2012, Journal of Molecular Neuroscience.

In vivo Detection of a PARACEST Agent in Mouse Brain Tumors

R. Menon, J. Gati, R. Bartha, 2009 .

Brain pH Measurement Using AACID CEST MRI Incorporating the 2 ppm Amine Resonance

R. Bartha, S. Meakin, Mohammed Albatany, 2022, Tomography.

Nesca, a novel neuronal adapter protein, links the molecular motor kinesin with the pre‐synaptic membrane protein, syntaxin‐1, in hippocampal neurons

S. Meakin, J. MacDonald, T. Hryciw, 2012, Journal of neurochemistry.

Tissue-specific alternative splicing generates two isoforms of the trkA receptor.

E. Shooter, S. Meakin, P. Barker, 1993, The Journal of biological chemistry.

morphological but not cholinergic phenotypic differentiation in response to nerve growth factor

S. Meakin, R. Rylett, B. Kalisch, 2002 .

PC12nnr5 cells expressing TrkA receptors undergo morphological but not cholinergic phenotypic differentiation in response to nerve growth factor

S. Meakin, R. Rylett, B. Kalisch, 2002, Journal of neurochemistry.

A Novel Juxtamembrane Deletion in Rat TrkA Blocks Differentiative but Not Mitogenic Cell Signaling in Response to Nerve Growth Factor

S. Meakin, I. Macdonald, 1998, Journal of neurochemistry.

p75 Co-receptors Regulate Ligand-dependent and Ligand-independent Trk Receptor Activation, in Part by Altering Trk Docking Subdomains*

S. Meakin, H. Saragovi, P. Pérez, 2001, The Journal of Biological Chemistry.

Trypanosome trans-sialidase mediates neuroprotection against oxidative stress, serum/glucose deprivation, and hypoxia-induced neurite retraction in Trk-expressing PC12 cells.

R. Contreras, S. Meakin, M. Szewczuk, 2007, Glycobiology.

Trk receptor binding and neurotrophin/fibroblast growth factor (FGF)-dependent activation of the FGF receptor substrate (FRS)-3.

S. Dixon, S. Meakin, J. MacDonald, 2006, Biochimica et biophysica acta.

Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis

S. Meakin, J. Verdi, C. Kubu, 2001, Mechanisms of Development.

Gene expression pattern Developmental expression patterns of the signaling adapters FRS-2 and FRS-3 during early embryogenesis

S. Meakin, J. Verdi, C. Kubu, 2001 .

The Signaling Adapter, FRS2, Facilitates Neuronal Branching in Primary Cortical Neurons via Both Grb2- and Shp2-Dependent Mechanisms

S. Meakin, Li Zhou, A. Talebian, 2014, Journal of Molecular Neuroscience.

A rabbit lens epithelial cell line supports expression of an exogenous crystallin gene characteristic of lens fiber cell differentiation.

L. Tsui, S. Meakin, M. Breitman, 1989, Experimental eye research.

A Kinase Insert Isoform of Rat TrkA Supports Nerve Growth Factor‐Dependent Cell Survival but Not Neurite Outgrowth

S. Meakin, J. MacDonald, E. Gryz, 1997, Journal of neurochemistry.

Chapter 7 Central mechanisms for autonomic dysreflexia after spinal cord injury

S. Meakin, Denis Gris, L. Weaver, 2002 .

Neutralizing intraspinal nerve growth factor with a trkA-IgG fusion protein blocks the development of autonomic dysreflexia in a clip-compression model of spinal cord injury.

S. Meakin, J. MacDonald, L. Weaver, 2002, Journal of neurotrauma.

Tyrosine kinase activity coupled to the high-affinity nerve growth factor-receptor complex.

E. Shooter, S. Meakin, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Relationship between proteins encoded by three human gamma-crystallin genes and distinct polypeptides in the eye lens

L. Tsui, S. Meakin, T. Hohman, 1987, Molecular and cellular biology.

Central mechanisms for autonomic dysreflexia after spinal cord injury.

S. Meakin, Denis Gris, L. Weaver, 2002, Progress in Brain Research.

TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1

S. Meakin, A. Talebian, Kim Robinson-Brookes, 2018, Journal of Molecular Neuroscience.

Activity-dependent interaction of the intracellular domain of rat TrkA with intermediate filament proteins, the β-6 proteasomal subunit, Ras-GRF1, and the p162 subunit of eIF3

S. Meakin, J. MacDonald, J. Verdi, 1999, Journal of Molecular Neuroscience.

Neurotrophin-dependent Tyrosine Phosphorylation of Ras Guanine-releasing Factor 1 and Associated Neurite Outgrowth Is Dependent on the HIKE Domain of TrkA*

R. Buchsbaum, S. Meakin, J. MacDonald, 2005, Journal of Biological Chemistry.

Nerve growth factor increases connexin43 phosphorylation and gap junctional intercellular communication

S. Meakin, A. M. Johnson, W. Rushlow, 2005, Journal of neuroscience research.

The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA

S. Meakin, J. MacDonald, J. Verdi, 1999, The Journal of Biological Chemistry.

Genomic organization and comparative sequence analysis of the mouse and human FRS2, FRS3 genes

S. Meakin, Li Zhou, J. Verdi, 2003, Molecular Biology Reports.

The nerve growth factor family of receptors

E. Shooter, S. Meakin, 1992, Trends in Neurosciences.

Direct Binding of the Signaling Adapter Protein Grb2 to the Activation Loop Tyrosines on the Nerve Growth Factor Receptor Tyrosine Kinase, TrkA*

S. Meakin, J. MacDonald, J. Verdi, 2000, The Journal of Biological Chemistry.

Molecular investigations on the high-affinity nerve growth factor receptor

E. Shooter, S. Meakin, 1991, Neuron.

Unravelling the Mechanism of TrkA-Induced Cell Death by Macropinocytosis in Medulloblastoma Daoy Cells

S. Michnick, S. Meakin, J. MacDonald, 2016, Molecular and Cellular Biology.

Role and expression of FRS2 and FRS3 in prostate cancer

S. Meakin, V. Gnanapragasam, T. Valencia, 2011, BMC Cancer.

ShcA regulates neurite outgrowth stimulated by neural cell adhesion molecule but not by fibroblast growth factor 2: evidence for a distinct fibroblast growth factor receptor response to neural cell adhesion molecule activation

V. Berezin, E. Bock, A. Hinsby, 2004, Journal of neurochemistry.

Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human neuroblastoma cell line, SY5Y

S. Meakin, E. Gryz, 2003, Oncogene.

Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-independent cell survival and neuronal differentiation

S. Meakin, E. Gryz, 2000, Oncogene.

Neutralizing Intraspinal Nerve Growth Factor Blocks Autonomic Dysreflexia Caused By Spinal Cord Injury

A. Krassioukov, S. Meakin, L. Weaver, 1999, The Journal of Neuroscience.

ShcB and ShcC Activation by the Trk Family of Receptor Tyrosine Kinases*

Hui-yu Liu, S. Meakin, 2002, The Journal of Biological Chemistry.

Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla

R. Bartha, S. Meakin, Alex X. Li, 2017, Journal of Neuro-Oncology.

Nesca, a novel adapter, translocates to the nuclear envelope and regulates neurotrophin-induced neurite outgrowth

S. Meakin, J. MacDonald, C. Kubu, 2004, The Journal of cell biology.

Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms

R. Bartha, S. Meakin, Mohammed Albatany, 2019, Journal of Neuro-Oncology.

Human Tumorous Imaginal Disc 1 (TID1) Associates with Trk Receptor Tyrosine Kinases and Regulates Neurite Outgrowth in nnr5-TrkA Cells*

Hui-yu Liu, S. Meakin, J. MacDonald, 2005, Journal of Biological Chemistry.

A differential role of extracellular signal-regulated kinase in stimulated PC12 pheochromocytoma cell movement.

S. Meakin, V. Morris, W. Ho, 2001, Experimental cell research.

Signaling adaptor ShcD suppresses extracellular signal-regulated kinase (Erk) phosphorylation distal to the Ret and Trk neurotrophic receptors

S. Meakin, Kévin Jacquet, Nicolas Bisson, 2017, The Journal of Biological Chemistry.

Trypanosome trans-sialidase targets TrkA tyrosine kinase receptor and induces receptor internalization and activation.

R. Contreras, S. Meakin, M. Szewczuk, 2004, Glycobiology.

Cyclic phosphatidic acid elicits neurotrophin‐like actions in embryonic hippocampal neurons

Y. Fujiwara, S. Meakin, G. Tigyi, 2003, Journal of neurochemistry.

The fibroblast growth factor receptor substrate 3 adapter is a developmentally regulated microtubule‐associated protein expressed in migrating and differentiated neurons

S. Meakin, J. MacDonald, S. Pasternak, 2010, Journal of neurochemistry.

Assignment of human gamma crystallin multigene family to chromosome 2

L. Tsui, H. Willard, S. Meakin, 1985, Somatic cell and molecular genetics.

The mammalian neuronal network consists of billions of neurons that form multiple connections to generate an interconnected circuit directing all aspects of life. The basis of these connections is the synapse where chemical information

S. Meakin, 2012 .

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

S. Meakin, S. Cregan, S. Pasternak, 2015, Molecular Brain.

In vivo detection of MRI‐PARACEST agents in mouse brain tumors at 9.4 T

Ravi S. Menon, J. Gati, R. Bartha, 2011, Magnetic resonance in medicine.

TrkB Regulates N-Methyl-D-Aspartate Receptor Signaling by Uncoupling and Recruiting the Brain-Specific Guanine Nucleotide Exchange Factor, RasGrf1

S. Meakin, A. Talebian, Kim Robinson-Brookes, 2018, Journal of Molecular Neuroscience.

Subpopulations of rat B2(+) neuroblasts exhibit differential neurotrophin responsiveness during sympathetic development.

S. Meakin, D. Goldhawk, J. Verdi, 2000, Developmental biology.

Ras Guanine Nucleotide Releasing Factor 1 (RasGrf1) Enhancement of Trk Receptor-Mediated Neurite Outgrowth Requires Activation of Both H-Ras and Rac

S. Meakin, J. MacDonald, A. Talebian, 2012, Journal of Molecular Neuroscience.

The rat trk protooncogene product exhibits properties characteristic of the slow nerve growth factor receptor.

E. Shooter, U. Suter, S. Meakin, 1992, Proceedings of the National Academy of Sciences of the United States of America.

In vivo detection of acute intracellular acidification in glioblastoma multiforme following a single dose of cariporide

R. Bartha, S. Meakin, Alex X. Li, 2018, International Journal of Clinical Oncology.

The Signaling Adapter, FRS2, Facilitates Neuronal Branching in Primary Cortical Neurons via Both Grb2- and Shp2-Dependent Mechanisms

S. Meakin, Li Zhou, A. Talebian, 2015, Journal of Molecular Neuroscience.

The Monocarboxylate transporter inhibitor Quercetin induces intracellular acidification in a mouse model of Glioblastoma Multiforme: in-vivo detection using magnetic resonance imaging

R. Bartha, S. Meakin, Mohammed Albatany, 2018, Investigational New Drugs.

Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes

S. Meakin, S. Cregan, S. Pasternak, 2015, Molecular Brain.

Isolation of transcriptionally regulated sequences associated with neuronal and non-neuronal cell interactions.

E. Shooter, U. Suter, S. Meakin, 1992, Progress in brain research.

Brain tumor acidification using drugs simultaneously targeting multiple pH regulatory mechanisms

R. Bartha, S. Meakin, Mohammed Albatany, 2019, Journal of Neuro-Oncology.