C. Howe

发表

Nerve growth factor signaling, neuroprotection, and neural repair.

M. Sofroniew, C. Howe, W. Mobley, 2001, Annual review of neuroscience.

Modeling the signaling endosome hypothesis: Why a drive to the nucleus is better than a (random) walk

C. Howe, Charles L Howe, 2005, Theoretical Biology and Medical Modelling.

NGF Signals through TrkA to Increase Clathrin at the Plasma Membrane and Enhance Clathrin-Mediated Membrane Trafficking

F. Brodsky, C. Howe, W. Mobley, 2000, The Journal of Neuroscience.

Picornaviruses and cell death.

C. Howe, E. Buenz, 2006, Trends in microbiology.

Retrograde interferon‐gamma signaling induces major histocompatibility class I expression in human‐induced pluripotent stem cell‐derived neurons

C. Howe, B. Clarkson, Misha Patel, 2017, Annals of clinical and translational neurology.

Long-distance retrograde neurotrophic signaling

C. Howe, W. Mobley, 2005, Current Opinion in Neurobiology.

Automated identification of multiple seizure-related and interictal epileptiform event types in the EEG of mice

Armando Manduca, Hee-Sup Shin, Jee Hyun Choi, 2013, Scientific Reports.

TRAIL mediates liver injury by the innate immune system in the bile duct–ligated mouse

G. Gores, A. Kahraman, C. Howe, 2008, Hepatology.

Neuromyelitis Optica and Herpes Simplex Virus 2: A Viral Trigger for Aquaporin-4 Autoimmunity?

C. Lucchinetti, C. Howe, W. Tobin, 2018, The neurologist.

SUBCUTANEOUS IGF-1 IS NOT BENEFICIAL IN 2-YEAR ALS TRIAL

C. Howe, B. Horazdovsky, R. A. Bergstrom, 2009, Neurology.

Remyelination-Promoting DNA Aptamer Conjugate Myaptavin-3064 Binds to Adult Oligodendrocytes In Vitro

Aaron J. Johnson, Moses Rodriguez, C. Howe, 2020, Pharmaceuticals.

Teriflunomide shifts the astrocytic bioenergetic profile from oxidative metabolism to glycolysis and attenuates TNFα-induced inflammatory responses

C. Lucchinetti, C. Howe, B. Clarkson, 2022, Scientific Reports.

Molecular Mechanisms in the Genesis of Seizures and Epilepsy Associated With Viral Infection

W. Löscher, C. Howe, 2022, Frontiers in Molecular Neuroscience.

CD8+ T cells directed against a viral peptide contribute to loss of motor function by disrupting axonal transport in a viral model of fulminant demyelination

Aaron J. Johnson, Moses Rodriguez, D. Ure, 2007, Journal of Neuroimmunology.

Beta-methylamino-alanine (BMAA) injures hippocampal neurons in vivo.

C. Howe, E. Buenz, 2007, Neurotoxicology.

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain

C. Howe, Reghann G. LaFrance-Corey, Rhianna S. Sundsbak, 2012, Journal of Neuroinflammation.

Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons

C. Howe, B. Clarkson, R. Kahoud, 2017, Scientific Reports.

Nerve growth factor and the neurotrophic factor hypothesis

D. Holtzman, C. Howe, W. Mobley, 1996, Brain and Development.

Antiapoptotic signaling by a remyelination-promoting human antimyelin antibody

Moses Rodriguez, L. Pease, C. Howe, 2004, Neurobiology of Disease.

Human Monoclonal IgM Antibody Promotes CNS Myelin Repair Independent of Fc Function

Moses Rodriguez, L. Pease, C. Howe, 2003, Brain pathology.

A high‐throughput 3‐parameter flow cytometry‐based cell death assay

C. Howe, E. Buenz, P. Limburg, 2007, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes

C. Howe, Chandra Deb, 2009, Journal of Neuroimmunology.

Demyelinated Axons and Motor Function Are Protected by Genetic Deletion of Perforin in a Mouse Model of Multiple Sclerosis

Moses Rodriguez, C. Howe, Reghann G. LaFrance-Corey, 2009, Journal of neuropathology and experimental neurology.

Isolation of brain-infiltrating leukocytes.

C. Howe, Reghann G. LaFrance-Corey, 2011, Journal of visualized experiments : JoVE.

CD8+ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis

Moses Rodriguez, A. Windebank, C. Howe, 2010, PloS one.

Proteolipid Protein Gene Expression in Demyelination and Remyelination of the Central Nervous System: A Model for Multiple Sclerosis

Moses Rodriguez, C. Howe, N. Prayoonwiwat, 1994, Journal of neuropathology and experimental neurology.

Pathogenic implications of cerebrospinal fluid barrier pathology in neuromyelitis optica

S. Weigand, J. Parisi, C. Lucchinetti, 2017, Acta Neuropathologica.

Functional deficiency in endogenous interleukin‐1 receptor antagonist in patients with febrile infection‐related epilepsy syndrome

C. Howe, B. Clarkson, Reghann G. LaFrance-Corey, 2019, Annals of neurology.

Febrile infection‐related epilepsy syndrome treated with anakinra

E. Wirrell, C. Howe, A. Vezzani, 2016, Annals of neurology.

Dendritic Cells Uptake and Retention in Mature Myeloid TREM-2 Mediated Signaling Induces Antigen

Moses Rodriguez, L. Pease, M. Colonna, 2017 .

TREM-2 Mediated Signaling Induces Antigen Uptake and Retention in Mature Myeloid Dendritic Cells1

Moses Rodriguez, L. Pease, M. Colonna, 2008, The Journal of Immunology.

Rejuvenation of the aged brain immune cell landscape in mice through p16-positive senescent cell clearance

Aaron J. Johnson, E. Thompson, J. Kachergus, 2022, Nature Communications.

Depolarization of PC12 cells induces neurite outgrowth and enhances nerve growth factor-induced neurite outgrowth in rats

C. Howe, 2003, Neuroscience Letters.

Coated Glass and Vicryl Microfibers as Artificial Axons

C. Howe, 2006, Cells Tissues Organs.

A randomized Phase I study of Atuna racemosa: a potential new anti-MRSA natural product extract.

B. Bauer, D. Wahner-Roedler, C. Howe, 2007, Journal of ethnopharmacology.

Insula and the Immune System: More than mere Co-existence?

B. Lundstrom, J. V. Van Gompel, C. Howe, 2022, Neuroscience Bulletin.

ISGylation is induced in neurons by demyelination driving ISG15-dependent microglial activation

C. Howe, B. Clarkson, K. David, 2022, Journal of Neuroinflammation.

Absence of perforin expression confers axonal protection despite demyelination

Moses Rodriguez, C. Howe, Jaimie D. Adelson, 2007, Neurobiology of Disease.

Peripheral blood mononuclear cell phenotype and function are maintained after overnight shipping of whole blood

C. Howe, Renee K. Johnson, J. Sagen, 2022, Scientific Reports.

NKG2D contributes to efficient clearance of picornavirus from the acutely infected murine brain

C. Howe, Chandra Deb, 2008, Journal of NeuroVirology.

Signaling endosome hypothesis: A cellular mechanism for long distance communication.

William C Mobley, C. Howe, W. Mobley, 2004, Journal of neurobiology.

Searching historical herbal texts for potential new drugs

H. E. Johnson, B. Bauer, C. Howe, 2006, BMJ : British Medical Journal.

Systemic evidence of acute seizure-associated elevation in serum neuronal injury biomarker in patients with temporal lobe epilepsy

G. Worrell, C. Howe, F. Khadjevand, 2019, Acta Epileptologica.

Systemic evidence of acute seizure-associated neuronal injury in patients with temporal lobe epilepsy

G. Worrell, C. Howe, F. Khadjevand, 2017, bioRxiv.

STAT4‐ and STAT6‐signaling molecules in a murine model of multiple sclerosis

Moses Rodriguez, L. Pease, C. Howe, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.

Chadwick M. Hales, J. Derisi, J. Cheville, 2020, JAMA neurology.

Aquaporin-4–binding autoantibodies in patients with neuromyelitis optica impair glutamate transport by down-regulating EAAT2

C. Lucchinetti, C. Howe, S. Roemer, 2008, The Journal of experimental medicine.

Preservation of antigen-specific responses in cryopreserved CD4+ and CD8+ T cells expanded with IL-2 and IL-7

C. Howe, B. Clarkson, Renee K. Johnson, 2022, Journal of translational autoimmunity.

Leucine Zipper 4 Autoantibody: A Novel Germ Cell Tumor and Paraneoplastic Biomarker

J. Cheville, B. Leibovich, B. Costello, 2021, Annals of neurology.

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

C. Howe, Reghann G. LaFrance-Corey, Kanish Mirchia, 2017, Journal of Neuroinflammation.

Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis

C. Lucchinetti, C. Howe, J. Wilkins, 2020, Aging.

Remyelination as Neuroprotection

Moses Rodriguez, C. Howe, 2005, Multiple Sclerosis As A Neuronal Disease.

Axons are injured by antigen-specific CD8+ T cells through a MHC class I- and granzyme B-dependent mechanism

C. Howe, William F. Schmalstieg, B. Sauer, 2013, Neurobiology of Disease.

Inflammatory cytokine-induced changes in neural network activity measured by waveform analysis of high-content calcium imaging in murine cortical neurons

C. Howe, B. Clarkson, R. Kahoud, 2017, Scientific Reports.

Neuropilin-1 modulates interferon-γ-stimulated signaling in brain microvascular endothelial cells

D. Mukhopadhyay, C. Lucchinetti, C. Howe, 2016, Journal of Cell Science.

Trafficking the NGF signal: implications for normal and degenerating neurons.

C. Howe, W. Mobley, J. Cooper, 2004, Progress in brain research.

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures.

C. Howe, Christopher L. German, Brian M. Sauer, 2011, Experimental cell research.

Disrupted spatial memory is a consequence of picornavirus infection

Moses Rodriguez, C. Howe, E. Buenz, 2006, Neurobiology of Disease.

Infusion of nerve growth factor (NGF) into kitten visual cortex increases immunoreactivity for NGF, NGF receptors, and choline acetyltransferase in basal forebrain without affecting ocular dominance plasticity or column development

M. Stryker, A. Antonini, D. C. Gillespie, 2001, Neuroscience.

Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection

C. Howe, E. Buenz, Reghann G. LaFrance-Corey, 2012, Scientific Reports.

Immunopathology and Infectious Diseases Apoptosis of Hippocampal Pyramidal Neurons Is Virus Independent in a Mouse Model of Acute Neurovirulent Picornavirus Infection

C. Howe, E. Buenz, Reghann G. LaFrance-Corey, 2010 .

IgM Natural Autoantibodies in Physiology and the Treatment of Disease.

Moses Rodriguez, C. Howe, T. Nayfeh, 2018, Methods in molecular biology.

Fueling the FIRES: Hemophagocytic lymphohistiocytosis in febrile infection‐related epilepsy syndrome

Elizabeth M. Wells, C. Howe, J. Carpenter, 2018, Epilepsia.

Gamma Interferon Is Critical for Neuronal Viral Clearance and Protection in a Susceptible Mouse Strain following Early Intracranial Theiler's Murine Encephalomyelitis Virus Infection

Moses Rodriguez, C. Howe, S. Nakane, 2003, Journal of Virology.

Human HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic Demyelination

Moses Rodriguez, L. Pease, C. Howe, 2008, Journal of Virology.

Immunological aspects of axon injury in multiple sclerosis.

C. Howe, 2008, Current topics in microbiology and immunology.

Erratum: Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC (The FASEB Journal (2006) 20, 13 (2408-2410) DOI: 10.1096/fj.06-6171fje)

Moses Rodriguez, L. Pease, C. Howe, 2010 .

Induction of a gene expression program in dendritic cells with a cross-linking IgM antibody to the co-stimulatory molecule B7-DC.

Moses Rodriguez, L. Pease, C. Howe, 2006, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inflammatory monocytes and microglia play independent roles in inflammatory ictogenesis

C. Howe, B. Clarkson, Reghann G. LaFrance-Corey, 2022, Journal of neuroinflammation.

Differential endocytic sorting of p75NTR and TrkA in response to NGF: a role for late endosomes in TrkA trafficking

P. Steiner, C. Howe, S. Saxena, 2005, Molecular and Cellular Neuroscience.

Therapeutic doses of cranial irradiation induce hippocampus-dependent cognitive deficits in young mice

C. Howe, C. Wetmore, P. Decker, 2011, Journal of Neuro-Oncology.

NGF Signaling from Clathrin-Coated Vesicles Evidence that Signaling Endosomes Serve as a Platform for the Ras-MAPK Pathway

C. Howe, W. Mobley, A. Rusnak, 2001, Neuron.

Preparation of biologically active subcellular fractions using the Balch homogenizer.

C. Howe, Christopher L. German, 2009, Analytical biochemistry.

Interleukin-6 Protects Anterior Horn Neurons from Lethal Virus-Induced Injury

Aaron J. Johnson, R. Ransohoff, Moses Rodriguez, 2003, The Journal of Neuroscience.

Influenza vaccine and Guillain-Barré syndrome: making informed decisions

C. Howe, G. Poland, Caroline M. Poland, 2013, The Lancet.

NFκB signaling drives pro-granulocytic astroglial responses to neuromyelitis optica patient IgG

C. Lucchinetti, C. Howe, Yong Guo, 2015, Journal of Neuroinflammation.

Neuromyelitis optica IgG stimulates an immunological response in rat astrocyte cultures

C. Lucchinetti, C. Howe, Reghann G. LaFrance-Corey, 2014, Glia.

Citrullinated myelin induces microglial TNFα and inhibits endogenous repair in the cuprizone model of demyelination

C. Howe, Ethan M. Grund, Miranda M Standiford, 2021, Journal of neuroinflammation.

Review and standard operating procedures for collection of biospecimens and analysis of biomarkers in new onset refractory status epilepticus

E. Aronica, I. Helbig, N. Gaspard, 2023, Epilepsia.

Drug‐resistant seizures associated with hyperinflammatory monocytes in FIRES

C. Howe, R. Farias-Moeller, Renee K. Johnson, 2023, Annals of clinical and translational neurology.

A signaling endosome hypothesis to explain NGF actions: potential implications for neurodegeneration.

C. Howe, W. Mobley, M. Grimes, 1996, Cold Spring Harbor symposia on quantitative biology.

Methods for intratumoral microdialysis probe targeting and validation in murine brain tumor models

J. Sarkaria, C. Howe, W. Elmquist, 2021, Journal of Neuroscience Methods.

Failed retrograde transport of NGF in a mouse model of Down's syndrome: Reversal of cholinergic neurodegenerative phenotypes following NGF infusion

Ahmad Salehi, Jonathan D. Cooper, Charles J. Epstein, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Neuronal CCL2 expression drives inflammatory monocyte infiltration into the brain during acute virus infection

C. Howe, Reghann G. LaFrance-Corey, Kanish Mirchia, 2017, bioRxiv.

Microdialysis and microperfusion electrodes in neurologic disease monitoring

A. Kouzani, G. Worrell, K. Bennet, 2021, Fluids and barriers of the CNS.

Activated microglia stimulate transcriptional changes in primary oligodendrocytes via IL-1β

Moses Rodriguez, C. Howe, S. Mayoral, 2006, Neurobiology of Disease.

Tumor Necrosis Factor α is Reparative via TNFR1 in the Hippocampus and via TNFR2 in the Striatum after Virus‐Induced Encephalitis

S. Macura, Moses Rodriguez, C. Howe, 2009, Brain pathology.

G9a Modulates Lipid Metabolism in CD4 T cells to Regulate Intestinal Inflammation.

T. Smyrk, C. Howe, Michelle M. Gonzalez, 2022, Gastroenterology.

Neuroprotection mediated by inhibition of calpain during acute viral encephalitis

C. Howe, J. Reid, E. Buenz, 2016, Scientific Reports.

Differences in the surface binding and endocytosis of neurotrophins by p75NTR

C. Howe, S. Saxena, J. Weis, 2004, Molecular and Cellular Neuroscience.

Septin‐5 and ‐7‐IgGs: Neurologic, Serologic, and Pathophysiologic Characteristics

C. Howe, M. Wilson, B. Clarkson, 2022, Annals of neurology.

Neuromyelitis optica unique area postrema lesions

S. Weigand, J. Parisi, B. Weinshenker, 2011, Neurology.

Inflammatory changes in the central nervous system are associated with behavioral impairment in Plasmodium berghei (strain ANKA)-infected mice.

C. Howe, M. Teixeira, A. Teixeira, 2010, Experimental parasitology.

Intrathecal Dexamethasone in Febrile Infection-Related Epilepsy Syndrome: A Case Report.

C. Howe, K. Maloney, R. Farias-Moeller, 2023, Neurology. Clinical practice.

Encephalomyelitis Virus Infection Intracranial Theiler ' s Murine Susceptible Mouse Strain following Early Viral Clearance and Protection in a Gamma Interferon Is Critical for Neuronal

Moses Rodriguez, C. Howe, C. Stuart-harris, 2003 .

Inflammatory monocytes damage the hippocampus during acute picornavirus infection of the brain

C. Howe, Rhianna S. Sundsbak, Stephanie J. LaFrance, 2012, Journal of Neuroinflammation.

Human HLA-DR Transgenes Protect Mice from Fatal Virus-Induced Encephalomyelitis and Chronic Demyelination

Moses Rodriguez, L. Pease, C. Howe, 2008, Journal of Virology.

Isolation of brain-infiltrating leukocytes.

C. Howe, Reghann Lafrance-Corey, 2011, Journal of visualized experiments : JoVE.

Growth factor treatment of demyelinating disease: at last, a leap into the light.

R. Ransohoff, Moses Rodriguez, C. Howe, 2002, Trends in immunology.

Functional characterization of mouse spinal cord infiltrating CD8+ lymphocytes

C. Howe, Chandra Deb, 2009, Journal of Neuroimmunology.

The STAT3 beacon: IL-6 recurrently activates STAT 3 from endosomal structures.

C. Howe, Christopher L. German, B. Sauer, 2011, Experimental cell research.