P. Barker

发表

New Views on the Misconstrued: Executioner Caspases and Their Diverse Non-apoptotic Roles

N. Unsain, P. Barker, Nicolás Unsain, 2015, Neuron.

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle development.

P. Barker, I. Thesleff, M. Mikkola, 2008, Human molecular genetics.

LGI1 Is a Nogo Receptor 1 Ligand that Antagonizes Myelin-Based Growth Inhibition

M. Pool, A. Fournier, P. Barker, 2010, The Journal of Neuroscience.

Critical Roles for the Netrin Receptor Deleted in Colorectal Cancer in Dopaminergic Neuronal Precursor Migration, Axon Guidance, and Axon Arborization

A. Sadikot, L. Trudeau, T. Kennedy, 2010, Neuroscience.

Nerve Growth Factor Signaling and Its Contribution to Pain

L. Arendt-Nielsen, P. Mantyh, P. Barker, 2020, Journal of pain research.

Cellular inhibitors of apoptosis cIAP1 and cIAP2 are required for innate immunity signaling by the pattern recognition receptors NOD1 and NOD2.

M. Bertrand, P. Barker, R. Korneluk, 2009, Immunity.

Apoptotic sensitivity of murine IAP-deficient cells.

M. Bertrand, T. Mak, C. Duckett, 2008, The Biochemical journal.

An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1

C. Duckett, P. Barker, N. Kenneth, 2012, The Biochemical journal.

A p75NTR Pivoting Paradigm Propels Perspicacity

P. Barker, 2009, Neuron.

S100B protein activates a RAGE‐dependent autocrine loop in astrocytes: implications for its role in the propagation of reactive gliosis

P. Barker, Maria Florencia Angelo, A. Villarreal, 2014, Journal of neurochemistry.

AEG3482 is an antiapoptotic compound that inhibits Jun kinase activity and cell death through induced expression of heat shock protein 70.

Stephen J. Morris, P. Barker, W. Ho, 2006, Chemistry & biology.

Photic injury promotes cleavage of p75NTR by TACE and nuclear trafficking of the p75 intracellular domain

R. Black, P. Barker, S. Frank, 2007, Molecular and Cellular Neuroscience.

Constitutive nuclear factor-kappa B activity is required for central neuron survival.

David S. Park, P. Barker, M. Russo, 2002, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Constitutive Nuclear Factor-κB Activity Is Required for Central Neuron Survival

David S. Park, P. Barker, M. Russo, 2002, The Journal of Neuroscience.

ASPP1/2 Regulate p53-Dependent Death of Retinal Ganglion Cells through PUMA and Fas/CD95 Activation In Vivo

A. Di Polo, E. Feinstein, N. Unsain, 2013, The Journal of Neuroscience.

Nuclear factor-kappaB induced by doxorubicin is deficient in phosphorylation and acetylation and represses nuclear factor-kappaB-dependent transcription in cancer cells.

P. Barker, W. Ho, K. Dickson, 2005, Cancer research.

Calpain-dependent truncated form of TrkB-FL increases in neurodegenerative processes

N. Unsain, P. Barker, D. Mascó, 2016, Molecular and Cellular Neuroscience.

Week in The Journal F Cellular / Molecular cAMP and a Retinal Clock

D. Hommer, D. Storm, M. Koenig, 2004 .

TTIP is a novel protein that interacts with the truncated T1 TrkB neurotrophin receptor.

P. Barker, D. Kryl, 2000, Biochemical and biophysical research communications.

CD95–CD95L: can the brain learn from the immune system?

B. Becher, J. Antel, P. Barker, 1998, Trends in Neurosciences.

Tissue-specific alternative splicing generates two isoforms of the trkA receptor.

E. Shooter, S. Meakin, P. Barker, 1993, The Journal of biological chemistry.

Generation of the truncated form of the nerve growth factor receptor by rat Schwann cells. Evidence for post-translational processing.

R. A. Murphy, P. Barker, F. Miller, 1991, The Journal of biological chemistry.

Extended Ceramide Exposure Activates the trkA Receptor by Increasing Receptor Homodimer Formation

P. Barker, I. MacPhee, Ian J. MacPhee, 1999, Journal of neurochemistry.

Tumor Necrosis Factor-α Triggers Mucus Production in Airway Epithelium through an IκB Kinase β-dependent Mechanism*

P. Barker, C. Fraser, J. Gutiérrez-Ramos, 2005, Journal of Biological Chemistry.

The Atypical Protein Kinase C-interacting Protein p62 Is a Scaffold for NF-κB Activation by Nerve Growth Factor*

P. Barker, M. Diaz-Meco, J. Moscat, 2001, The Journal of Biological Chemistry.

Observations on the function of nuclear factor kappa B (NF-κB) in the survival of adult primary sensory neurons after nerve injury

G. Michael, P. Barker, C. Magoulas, 2009, Molecular and Cellular Neuroscience.

Apoptosis Induced by p75NTR Overexpression Requires Jun Kinase-Dependent Phosphorylation of Bad

Esther B. E. Becker, P. Barker, A. Bonni, 2003, The Journal of Neuroscience.

Blocking nerve growth factor binding to the p75 neurotrophin receptor on sympathetic neurons transiently reduces trkA activation but does not affect neuronal survival

P. Barker, D. Belliveau, C. Lachance, 1997, Neuroscience.

The carboxyl terminus of nerve growth factor is required for biological activity.

E. Shooter, U. Suter, P. Barker, 1993, The Journal of biological chemistry.

TRAF6‐dependent NF‐kB transcriptional activity during mouse development

P. Barker, A. Bhakar, K. Dickson, 2004, Developmental dynamics : an official publication of the American Association of Anatomists.

Proneurotrophins Require Endocytosis and Intracellular Proteolysis to Induce TrkA Activation*

P. Barker, K. Neet, C. Céni, 2008, Journal of Biological Chemistry.

Multiple Sclerosis: Fas Signaling in Oligodendrocyte Cell Death

J. Antel, P. Barker, C. Raine, 1996, The Journal of experimental medicine.

cIAP2 supports viability of mice lacking cIAP1 and XIAP

M. Bertrand, P. Barker, Kristen N Heard, 2015, The EMBO journal.

cIAP 2 supports viability of mice lacking cIAP 1 and XIAP

M. Bertrand, P. Barker, Kristen N Heard, 2015 .

Stress‐induced expression of the p75 neurotrophin receptor is regulated by O‐GlcNAcylation of the Sp1 transcription factor

P. Barker, R. Kommaddi, K. Dickson, 2011, Journal of neurochemistry.

NRAGE, A Novel MAGE Protein, Interacts with the p75 Neurotrophin Receptor and Facilitates Nerve Growth Factor–Dependent Apoptosis

Philippe P Roux, P. Barker, A. Bhakar, 2000, Neuron.

An improved method for the isolation of rat cardiac sarcoplasmic reticulum

P. Barker, A. Belcastro, J. Gilchrist, 1988, Molecular and Cellular Biochemistry.

Retrograde signaling by the neurotrophins follows a well-worn trk

P. McPherson, P. Barker, N. K. Hussain, 2002, Trends in Neurosciences.

Getting RIP’d Stunts Your Growth

P. Barker, C. Céni, 2005, Neuron.

p75 Neurotrophin Receptor Expression Is Induced in Apoptotic Neurons After Seizure

Philippe P Roux, T. Kennedy, P. Barker, 1999, The Journal of Neuroscience.

Regulation of a Truncated Form of Tropomyosin-Related Kinase B (TrkB) by Hsa-miR-185* in Frontal Cortex of Suicide Completers

P. Barker, G. Turecki, N. Mechawar, 2012, PloS one.

K252a and CEP1347 Are Neuroprotective Compounds That Inhibit Mixed-lineage Kinase-3 and Induce Activation of Akt and ERK*

Philippe P Roux, P. Barker, S. Morris, 2002, The Journal of Biological Chemistry.

Blocking gephyrin phosphorylation or microglia BDNF signaling prevents synapse loss and reduces infarct volume after ischemia

Steven A. Brown, M. Vaas, P. Barker, 2020, bioRxiv.

p75 Neurotrophin Receptor Cleavage by α- and γ-Secretases Is Required for Neurotrophin-mediated Proliferation of Brain Tumor-initiating Cells*

G. Gibney, P. Barker, M. K. Cooper, 2014, The Journal of Biological Chemistry.

Tumor-initiating Cells Neurotrophin-mediated Proliferation of-Secretases Is Required for γ and-α p 75 Neurotrophin Receptor Cleavage by Neurobiology :

G. Gibney, P. Barker, M. K. Cooper, 2014 .

cIAP1 and cIAP2 facilitate cancer cell survival by functioning as E3 ligases that promote RIP1 ubiquitination.

M. Bertrand, P. Barker, W. Ho, 2008, Molecular cell.

Detection of brain-derived neurotrophic factor-like activity in fibroblasts and Schwann cells: Inhibition by antibodies to NGF

R. A. Murphy, P. Barker, F. Miller, 1991, Neuron.

De novo mutations in the gene encoding the synaptic scaffolding protein SHANK3 in patients ascertained for schizophrenia

Marie-Pierre Dubé, Christian Néri, Marie-Odile Krebs, 2010, Proceedings of the National Academy of Sciences.

Whither proBDNF?

P. Barker, 2009, Nature Neuroscience.

Excitotoxic Death of Retinal Neurons In Vivo Occurs via a Non-Cell-Autonomous Mechanism

A. Di Polo, P. Barker, D. Bowie, 2009, The Journal of Neuroscience.

p75NTR-dependent Rac1 activation requires receptor cleavage and activation of an NRAGE and NEDD9 signaling cascade

P. Barker, Amir H Salehi, M. Zeinieh, 2015, Journal of Cell Science.

The p75 neurotrophin receptor: multiple interactors and numerous functions.

P. Barker, B. Carter, J. J. Gentry, 2004, Progress in brain research.

Neurotrophins in the regulation of cellular survival and death.

N. Unsain, P. Barker, M. Zeinieh, 2014, Handbook of experimental pharmacology.

Vasculature Guides Migrating Neuronal Precursors in the Adult Mammalian Forebrain via Brain-Derived Neurotrophic Factor Signaling

A. Parent, C. Gravel, M. Götz, 2009, The Journal of Neuroscience.

Neurotrophin signaling through the p75 neurotrophin receptor

Philippe P Roux, P. Barker, 2002, Progress in Neurobiology.

Interaction and Antagonistic Roles of NF-κB and Hes6 in the Regulation of Cortical Neurogenesis

P. Barker, R. Slack, R. Lo, 2013, Molecular and Cellular Biology.

Stabilization of p73 by Nuclear IκB Kinase-α Mediates Cisplatin-induced Apoptosis*

A. Nakagawara, P. Barker, T. Ozaki, 2007, Journal of Biological Chemistry.

The epilepsy gene LGI1 encodes a secreted glycoprotein that binds to the cell surface.

P. Barker, V. Herranz-Pérez, J. Pérez-Tur, 2006, Human molecular genetics.

XIAP regulates caspase activity in degenerating axons.

N. Unsain, P. Barker, Kristen Parker, 2013, Cell reports.

The nerve growth factor receptor: a multicomponent system that mediates the actions of the neurotrophin family of proteins

R. A. Murphy, P. Barker, 1992, Molecular and Cellular Biochemistry.

The p75 Neurotrophin Receptor Can Induce Autophagy and Death of Cerebellar Purkinje Neurons

T. Laessig, K. Heidenreich, P. Barker, 2004, The Journal of Neuroscience.

p75NTR: A study in contrasts

P. Barker, 1998, Cell Death and Differentiation.

The p75 Neurotrophin Receptor (p75NTR) Alters Tumor Necrosis Factor-mediated NF-κB Activity under Physiological Conditions, but Direct p75NTR-mediated NF-κB Activation Requires Cell Stress*

Philippe P Roux, P. Barker, A. Bhakar, 1999, The Journal of Biological Chemistry.

Brain-derived Neurotrophic Factor Binding to the p75 Neurotrophin Receptor Reduces TrkA Signaling While Increasing Serine Phosphorylation in the TrkA Intracellular Domain*

P. Barker, Ian J. MacPhee, 1997, The Journal of Biological Chemistry.

The Interaction Between the Two Receptors for NGF, p75LNTR and TrkA

E. Shooter, P. Barker, 1995 .

p75 Neurotrophin Receptor Expression on Adult Human Oligodendrocytes: Signaling without Cell Death in Response to NGF

P. Barker, A. Bhakar, U. Ladiwala, 1998, The Journal of Neuroscience.

p75 nerve growth factor receptor modulates p140trkA kinase activity, but not ligand internalization, in PC12 cells

E. Shooter, P. Barker, P. Kahle, 1994, Journal of neuroscience research.

Disruption of NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells

E. Shooter, P. Barker, 1994, Neuron.

Wengen, the Sole Tumour Necrosis Factor Receptor in Drosophila, Collaborates with Moesin to Control Photoreceptor Axon Targeting during Development

W. Ruan, J. Desbarats, N. Unsain, 2013, PloS one.

Nuclear Factor κB Signaling Regulates Neuronal Morphology and Cocaine Reward

E. Nestler, J. Neumaier, R. Neve, 2009, The Journal of Neuroscience.

Characterization of the c-Jun N-Terminal Kinase-BimEL Signaling Pathway in Neuronal Apoptosis

Esther B. E. Becker, P. Barker, A. Bonni, 2004, The Journal of Neuroscience.

NRAGE, a p75 Neurotrophin Receptor-interacting Protein, Induces Caspase Activation and Cell Death through a JNK-dependent Mitochondrial Pathway*

P. Barker, S. Xanthoudakis, Amir H Salehi, 2002, The Journal of Biological Chemistry.

NRAGE, a p75NTR adaptor protein, is required for developmental apoptosis in vivo

M. Bertrand, P. Barker, H. Nguyen, 2008, Cell Death and Differentiation.

Expression analysis of a novel p75NTR signaling protein, which regulates cell cycle progression and apoptosis

P. Barker, D. Goldhawk, J. Verdi, 2002, Mechanisms of Development.

Co-expression of the P75 neurotrophin receptor and neurotrophin receptor-interacting melanoma antigen homolog in the mature rat brain

U. Greferath, P. Barker, G. Barrett, 2005, Neuroscience.

The MAGE proteins: Emerging roles in cell cycle progression, apoptosis, and neurogenetic disease

P. Barker, Amir H Salehi, Philip A. Barker, 2002, Journal of neuroscience research.

Mutations in the calcium-related gene IL1RAPL1 are associated with autism.

E. Fombonne, S. Aradhya, M. Dubé, 2008, Human molecular genetics.

Protein Kinase A Activation Promotes Plasma Membrane Insertion of DCC from an Intracellular Pool: A Novel Mechanism Regulating Commissural Axon Extension

Philippe P Roux, N. Tritsch, T. Kennedy, 2004, The Journal of Neuroscience.

Identification of genetic variants of LGI1 and RTN4R (NgR1) linked to schizophrenia that are defective in NgR1–LGI1 signaling

G. Rouleau, P. Barker, A. Ambalavanan, 2016, Molecular genetics & genomic medicine.

Developmental Axon Degeneration Requires TRPV1-Dependent Ca2+ Influx

N. Unsain, P. Barker, J. Gibon, 2019, eNeuro.

Ligand-Dependent Cleavage of the P75 Neurotrophin Receptor Is Necessary for NRIF Nuclear Translocation and Apoptosis in Sympathetic Neurons

P. Barker, B. Hempstead, M. Chao, 2006, Neuron.

Neurotrophins and Proneurotrophins: Focus on Synaptic Activity and Plasticity in the Brain

P. Barker, J. Gibon, 2017, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis

P. Barker, Andrew Gloster, F. Miller, 1997, The Journal of Neuroscience.

TRPC channels underlie cholinergic plateau potentials and persistent activity in entorhinal cortex

A. Alonso, Zizhen Zhang, P. Séguéla, 2011, Hippocampus.

Soluble Adenylyl Cyclase Is Not Required for Axon Guidance to Netrin-1

T. Kennedy, P. Barker, M. Conti, 2008, The Journal of Neuroscience.

Towards the PET radiotracer for p75 neurotrophin receptor: [(11)C]LM11A-24 shows biological activity in vitro, but unfavorable ex vivo and in vivo profile.

P. Séguéla, P. Rosa-Neto, P. Barker, 2016, Bioorganic & medicinal chemistry.

p75NTR Is Positively Promiscuous Novel Partners and New Insights

P. Barker, 2004, Neuron.

LRRK2 localizes to endosomes and interacts with clathrin‐light chains to limit Rac1 activation

W. Ruan, P. McPherson, P. Barker, 2015, EMBO reports.

LRRK 2 localizes to endosomes and interacts with clathrin-light chains to limit Rac 1 activation

W. Ruan, P. McPherson, P. Barker, 2014 .

The p75 Neurotrophin Receptor Activates Akt (Protein Kinase B) through a Phosphatidylinositol 3-Kinase-dependent Pathway*

Philippe P Roux, T. Kennedy, P. Barker, 2001, The Journal of Biological Chemistry.

Soluble Tumor Necrosis Factor Alpha Promotes Retinal Ganglion Cell Death in Glaucoma via Calcium-Permeable AMPA Receptor Activation

A. Di Polo, N. Unsain, P. Barker, 2015, The Journal of Neuroscience.

Tumor necrosis factor-alpha triggers mucus production in airway epithelium through an IkappaB kinase beta-dependent mechanism.

P. Barker, C. Fraser, J. Gutiérrez-Ramos, 2005, The Journal of biological chemistry.

Something old, something new: BDNF-induced neuron survival requires TRPC channel function

W. Sossin, P. Barker, 2007, Nature Neuroscience.

High Salt Intake Increases Blood Pressure via BDNF-Mediated Downregulation of KCC2 and Impaired Baroreflex Inhibition of Vasopressin Neurons

P. Barker, C. Bourque, D. Voisin, 2015, Neuron.

Eiger-induced cell death relies on Rac1-dependent endocytosis

W. Ruan, P. Barker, k-I Kara, 2016, Cell Death and Disease.

NGF-Dependent and BDNF-Dependent DRG Sensory Neurons Deploy Distinct Degenerative Signaling Mechanisms

P. Barker, J. Gibon, A. de Léon, 2020, eNeuro.

Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

P. Séguéla, P. Barker, J. Gibon, 2016, Molecular Brain.

p75 neurotrophin receptor reduces ligand‐induced Trk receptor ubiquitination and delays Trk receptor internalization and degradation

P. Barker, D. Auld, C. Céni, 2005, EMBO reports.

Collapsin Response Mediator Protein 4 (CRMP4) Facilitates Wallerian Degeneration and Axon Regeneration following Sciatic Nerve Injury

A. Fournier, C. Deppmann, N. Unsain, 2020, eNeuro.

ProNGF induces TNFα-dependent death of retinal ganglion cells through a p75NTR non-cell-autonomous signaling pathway

M. Bertrand, O. de Backer, D. Stellwagen, 2010, Proceedings of the National Academy of Sciences.

High Affinity Not in the Vicinity?

P. Barker, Philip A Barker, 2007, Neuron.

The Nogo Receptor Ligand LGI1 Regulates Synapse Number and Synaptic Activity in Hippocampal and Cortical Neurons

P. Séguéla, K. Murai, P. Barker, 2018, eNeuro.

HBpF-proBDNF: A New Tool for the Analysis of Pro-Brain Derived Neurotrophic Factor Receptor Signaling and Cell Biology

P. Séguéla, P. Barker, J. Gibon, 2016, PloS one.

Trk‐dependent ADAM17 activation facilitates neurotrophin survival signaling

P. Barker, Rhalena A. Thomas, C. Céni, 2011, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

A Pro-Apoptotic Fragment of the p75 Neurotrophin Receptor Is Expressed in p75NTRExonIV Null Mice

P. Barker, E. Vereker, K. Dickson, 2004, The Journal of Neuroscience.

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling

P. McPherson, P. Barker, B. Ritter, 2010, Journal of Cell Science.

Hypo-Osmolar Stress Induces p75NTR Expression by Activating Sp1-Dependent Transcription

P. Barker, Kristy Favell, K. Dickson, 2007, The Journal of Neuroscience.

Increased Expression and Association of p75NTR and Nrage During Light-Induced Photoreceptor Cell Death

P. Barker, R. Roque, A. Brun‐Zinkernagel, 2002 .

Remodeling of the Actin/Spectrin Membrane-associated Periodic Skeleton, Growth Cone Collapse and F-Actin Decrease during Axonal Degeneration

N. Unsain, P. Barker, A. Cáceres, 2018, Scientific Reports.

The low affinity neurotrophin receptor, p75LNTR, is palmitoylated by thioester formation through cysteine 279.

E. Shooter, P. Barker, T. P. Misko, 1994, The Journal of biological chemistry.

Subcellular Localization of Full-Length and Truncated Trk Receptor Isoforms in Polarized Neurons and Epithelial Cells

E. Castrén, P. Barker, A. Haapasalo, 1999, The Journal of Neuroscience.

PITA, a pre-bilaterian p75NTR, is the evolutionary ancestor of TNF receptors

W. Sossin, P. Barker, J. Gibon, 2021, bioRxiv.

proBDNF and p75NTR Control Excitability and Persistent Firing of Cortical Pyramidal Neurons

P. Séguéla, V. Kaartinen, N. Unsain, 2015, The Journal of Neuroscience.

Production and isolation of axons from sensory neurons for biochemical analysis using porous filters.

N. Unsain, P. Barker, Kristen N Heard, 2014, Journal of visualized experiments : JoVE.

Stabilization of p73 by nuclear IkappaB kinase-alpha mediates cisplatin-induced apoptosis.

A. Nakagawara, P. Barker, T. Ozaki, 2007, Journal of Biological Chemistry.

Mitochondrial Reactive Oxygen Species Mediate Activation of TRPV1 and Calcium Entry Following Peripheral Sensory Axotomy

P. Barker, J. Gibon, Bradley Kievit, 2022, Frontiers in Molecular Neuroscience.

Isolation and characterization of a glycosylated form of beta nerve growth factor in mouse submandibular glands.

R. Campenot, R. A. Murphy, P. Barker, 1989, The Journal of biological chemistry.

Opposing presynaptic roles of BDNF and ProBDNF in the regulation of persistent activity in the entorhinal cortex

P. Séguéla, P. Barker, J. Gibon, 2016, Molecular Brain.

Production and isolation of axons from sensory neurons for biochemical analysis using porous filters.

P. Barker, Kristen N Heard, J. M. Higgins, 2014, Journal of visualized experiments : JoVE.