J. Brioni

发表

Muscimol injections in the medial septum impair spatial learning

J. D. McGaugh, I. Izquierdo, J. Brioni, 1990, Brain Research.

Pharmacological and molecular analysis of ATP-sensitive K(+) channels in the pig and human detrusor.

J. Sullivan, J. Brioni, S. Buckner, 2000, European journal of pharmacology.

Correlation between brain/plasma ratios and efficacy in neuropathic pain models of selective metabotropic glutamate receptor 1 antagonists.

Jill M. Wetter, J. Brioni, S. Baker, 2006, Bioorganic & medicinal chemistry letters.

Novel heterocyclic-substituted benzofuran histamine H3 receptor antagonists: in vitro properties, drug-likeness, and behavioral activity.

K. Browman, Jill M. Wetter, G. Diaz, 2007, Biochemical pharmacology.

A robust and high-capacity [(35)S]GTPgammaS binding assay for determining antagonist and inverse agonist pharmacological parameters of histamine H(3) receptor ligands.

J. Brioni, T. Esbenshade, M. Cowart, 2008, Assay and drug development technologies.

Pharmacology of human sulphonylurea receptor SUR1 and inward rectifier K+ channel Kir6.2 combination expressed in HEK‐293 cells

J. Sullivan, J. Brioni, C. Shieh, 2000, British journal of pharmacology.

Post-training administration of GABAergic antagonists enhances retention of aversively motivated tasks

J. D. McGaugh, J. Brioni, 2005, Psychopharmacology.

Benzodiazepine receptor mediation of the anxiolytic-like effect of (−)-nicotine in mice

J. Brioni, A. O'Neill, 1994, Pharmacology Biochemistry and Behavior.

(+/-)-Epibatidine elicits a diversity of in vitro and in vivo effects mediated by nicotinic acetylcholine receptors.

D. Donnelly-roberts, J. Sullivan, D. Anderson, 1994, The Journal of pharmacology and experimental therapeutics.

Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells.

J. Sullivan, J. Brioni, C. Shieh, 2001, The Journal of pharmacology and experimental therapeutics.

Discovery of histamine H 3 antagonists for the treatment of cognitive disorders and Alzheimer ’ s disease

J. Brioni, T. Esbenshade, M. Cowart, 2010 .

Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.

Jill M. Wetter, G. Diaz, J. Brioni, 2012, European journal of pharmacology.

Amnesia induced by short-term treatment with ethanol: Attenuation by pretest oxotremorine

J. D. McGaugh, I. Izquierdo, J. Brioni, 1989, Pharmacology Biochemistry and Behavior.

In-vivo histamine H3 receptor antagonism activates cellular signaling suggestive of symptomatic and disease modifying efficacy in Alzheimer’s disease

J. Brioni, R. Bitner, A. Nikkel, 2011, Neuropharmacology.

JPET Miniseries : H 3 Receptors Discovery of Histamine H 3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer ’ s Disease

J. Brioni, T. Esbenshade, M. Cowart, 2010 .

Pharmacological treatment of Alzheimer's disease : molecular and neurobiological foundations

J. Brioni, M. Decker, 1997 .

The novel calpain inhibitor A-705253 potently inhibits oligomeric beta-amyloid-induced dynamin 1 and tau cleavage in hippocampal neurons

J. Brioni, Adriana B Ferreira, R. Bitner, 2008, Neurochemistry International.

Clozapine attenuates the discriminative stimulus properties of (−)-nicotine

J. Brioni, M. Decker, A. O'Neill, 1994, Brain Research.

Novel isoxazoles which interact with brain cholinergic channel receptors have intrinsic cognitive enhancing and anxiolytic activities.

S. Arneric, J. Sullivan, D. Garvey, 1994, Journal of medicinal chemistry.

Characterization of the ATP-sensitive potassium channels (KATP) expressed in guinea pig bladder smooth muscle cells.

J. Sullivan, J. Brioni, C. Shieh, 1999, The Journal of pharmacology and experimental therapeutics.

Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channels

G. Dubé, J. Brioni, S. Baker, 2005, Pain.

Pharmacological and molecular characterization of ATP-sensitive K+ channels in the TE671 human medulloblastoma cell line.

J. Brioni, M. Gopalakrishnan, L. Monteggia, 1999, European journal of pharmacology.

In vivo evaluation of the potency and bladder‐vascular selectivity of the ATP‐sensitive potassium channel openers (–)‐cromakalim, ZD6169 and WAY‐133537 in rats

J. Brioni, M. Gopalakrishnan, J. J. Lynch, 2003, BJU international.

(−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9-hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637): A Novel ATP-Sensitive Potassium Channel Opener Efficacious in Suppressing Urinary Bladder Contractions. II. In Vivo Characterization

J. Sullivan, M. Williams, J. Brioni, 2002, Journal of Pharmacology and Experimental Therapeutics.

Characterization and modulation of [125I]iberiotoxin-D19Y/Y36F binding in the guinea-pig urinary bladder.

J. Brioni, M. Gopalakrishnan, J. Sullivan, 2000, European journal of pharmacology.

A-350619: a novel activator of soluble guanylyl cyclase.

M. Nakane, J. Brioni, R. Moreland, 2003, Life sciences.

Neuronal nicotinic receptors : pharmacology and therapeutic opportunities

S. Arneric, J. Brioni, 1999 .

A-412997 is a selective dopamine D4 receptor agonist in rats

Jill M. Wetter, J. Brioni, R. Moreland, 2005, Pharmacology Biochemistry and Behavior.

Enhancement of apomorphine‐induced penile erection in the rat by a selective α1D‐adrenoceptor antagonist

J. Sullivan, J. Brioni, K. Andersson, 2002, British journal of pharmacology.

Minimization of potential hERG liability in histamine H3 receptor antagonists

K. Browman, G. Diaz, J. Brioni, 2008, Inflammation Research.

Fatty acid amide hydrolase inhibitors display broad selectivity and inhibit multiple carboxylesterases as off-targets

J. Brioni, A. Saraf, J. Rogers, 2007, Neuropharmacology.

A-412997, a selective dopamine D4 agonist, improves cognitive performance in rats

K. Browman, J. Brioni, M. Decker, 2005, Pharmacology Biochemistry and Behavior.

Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists.

M. Nakane, J. Brioni, R. Moreland, 2005, Bioorganic & medicinal chemistry.

2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist

D. Donnelly-roberts, Jill M. Wetter, M. Nakane, 2005, Neuropharmacology.

Synthesis and functional activity of (2-aryl-1-piperazinyl)-N-(3-methylphenyl)acetamides: selective dopamine D4 receptor agonists.

D. Donnelly-roberts, M. Nakane, J. Brioni, 2004, Bioorganic & medicinal chemistry.

Effects of ATP‐sensitive K+ channel openers and tolterodine on involuntary bladder contractions in a pig model of partial bladder outlet obstruction

J. Sullivan, J. Brioni, M. Gopalakrishnan, 2003, Neurourology and urodynamics.

In vitro studies on a class of quinoline containing histamine H3 antagonists.

G. Diaz, J. Brioni, Ruth L. Martin, 2010, Bioorganic & medicinal chemistry letters.

Pharmacological properties and pro-cognitive effects of ABT-288, a potent and selective histamine H 3 receptor antagonist

K. Browman, J. Sullivan, J. Brioni, 2012 .

Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats.

J. Brioni, S. Baker, R. Moreland, 2008, European journal of pharmacology.

Dopamine D2, but not D4, receptor agonists are emetogenic in ferrets

M. Nakane, J. Brioni, R. Moreland, 2005, Pharmacology Biochemistry and Behavior.

[3H] A-369508 ([2-[4-(2-cyanophenyl)-1-piperazinyl]-N-(3-methylphenyl) acetamide): an agonist radioligand selective for the dopamine D4 receptor.

J. Brioni, R. Moreland, R. Chang, 2004, European journal of pharmacology.

Cloning and characterization of the monkey histamine H3 receptor isoforms.

J. Brioni, G. Fox, T. Vortherms, 2008, European journal of pharmacology.

Synthesis and activity of 2-[4-(4-[3H]-2-cyanophenyl)piperazinyl]-N-(2,4,6-[3H]3-3-methylphenyl)acetamide: a selective dopamine D4 receptor agonist and radioligand.

D. Donnelly-roberts, M. Nakane, J. Brioni, 2004, Bioorganic & medicinal chemistry letters.

Characterization of a novel ATP‐sensitive K+ channel opener, A‐251179, on urinary bladder relaxation and cystometric parameters

J. Brioni, C. Shieh, Y. Kurachi, 2007, British journal of pharmacology.

Pharmacological Properties and Procognitive Effects of ABT-288, a Potent and Selective Histamine H3 Receptor Antagonist

Min Zhang, Min Zhang, K. Browman, 2012, Journal of Pharmacology and Experimental Therapeutics.

Use of the H3 receptor antagonist radioligand [3H]‐A‐349821 to reveal in vivo receptor occupancy of cognition enhancing H3 receptor antagonists

K. Browman, J. Brioni, J. Bauch, 2009, British journal of pharmacology.

Modulation of the discriminative stimulus properties of (−)‐nicotine by diazepam and ethanol

J. Brioni, David J. B. Kim, Jorge D. Brioni, 1995 .

Pharmacological evaluation of an in vivo model of vestibular dysfunction in the rat.

J. Brioni, J. Sullivan, A. O'Neill, 1998, Methods and findings in experimental and clinical pharmacology.

Histaminergic ligands attenuate barrel rotation in rats following unilateral labyrinthectomy.

J. Brioni, A. Hancock, J. Sullivan, 1998, Methods and findings in experimental and clinical pharmacology.

Pretest β-endorphin and epinephrine, but not oxotremorine, reverse retrograde interference of a conditioned emotional response in mice

I. Izquierdo, J. Brioni, N. Barcik, 1989, Pharmacology Biochemistry and Behavior.

A clinical review of inhalation anesthesia with sevoflurane: from early research to emerging topics

B. Bein, J. Brioni, R. Ahmed, 2017, Journal of Anesthesia.

Discovery of 3-methyl-N-(1-oxy-3',4',5',6'-tetrahydro-2'H-[2,4'-bipyridine]-1'-ylmethyl)benzamide (ABT-670), an orally bioavailable dopamine D4 agonist for the treatment of erectile dysfunction.

D. Donnelly-roberts, Jill M. Wetter, G. Gintant, 2006, Journal of medicinal chemistry.

Structure-activity relationship of triazafluorenone derivatives as potent and selective mGluR1 antagonists.

Meena Patel, M. Nakane, J. Brioni, 2005, Journal of medicinal chemistry.

Synthesis and evaluation of benzothiazole-based analogues as novel, potent, and selective fatty acid amide hydrolase inhibitors.

Scott P. Brown, S. Muchmore, J. Brioni, 2009, Journal of medicinal chemistry.

Role of GABA during the multiple consolidation of memory

J. Brioni, 1993 .

Post-training systemic and intra-amygdala administration of the GABA-B agonist baclofen impairs retention.

J. D. McGaugh, J. Brioni, C. Castellano, 1989, Behavioral and neural biology.

Involvement of the amygdala GABAergic system in the modulation of memory storage

J. D. McGaugh, J. Brioni, A. Nagahara, 1989, Brain Research.

Spatial learning in rats exposed to acute ethanol intoxication on gestational day 8

J. Brioni, M. Arolfo, M. Virgolini, 1996, Pharmacology Biochemistry and Behavior.

Uninjured Rats Dynamic Range Neurons in CFA-Treated and Selective TRPV1 Receptor Antagonist, on Wide Systemic and Site-Specific Effects of A-425619, a

J. Brioni, A. Swensen, Lance Lee, 2015 .

Synthesis and Structure−Activity Relationships of a Novel Series of 2,3,5,6,7,9-Hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide KATP Channel Openers: Discovery of (−)-(9S)-9-(3-Bromo-4-fluorophenyl)-2,3,5,6,7,9- hexahydrothieno[3,2-b]quinolin-8(4H)-one 1,1-Dioxide (A-278637), a Potent KATP Open

J. Sullivan, R. Henry, J. Brioni, 2004 .

Rotationally constrained 2,4-diamino-5,6-disubstituted pyrimidines: a new class of histamine H4 receptor antagonists with improved druglikeness and in vivo efficacy in pain and inflammation models.

Jill M. Wetter, M. McPherson, J. Sullivan, 2008, Journal of medicinal chemistry.

Emerging Pharmacologic Approaches for the Treatment of Lower Urinary Tract Disorders

J. Sullivan, J. Brioni, R. Moreland, 2004, Journal of Pharmacology and Experimental Therapeutics.

TREATMENT OF LOWER URINARY TRACT DISORDERS

J. Sullivan, J. Brioni, R. Moreland, 2004 .

Nitric oxide independent activation of guanylate cyclase by YC-1 causes erectile responses in the rat.

J. Brioni, K. Andersson, J. Sullivan, 2002, The Journal of urology.

Activators of soluble guanylate cyclase for the treatment of male erectile dysfunction

M. Nakane, J. Brioni, R. Moreland, 2002, International Journal of Impotence Research.

Erysodine, a competitive antagonist at neuronal nicotinic acetylcholine receptors.

D. Donnelly-roberts, J. Sullivan, D. Anderson, 1995, European journal of pharmacology.

Preclinical Pharmacology of ABT‐418: A Prototypical Cholinergic Channel Activator for the Potential Treatment of Alzheimer's Disease

A. D. Rodrigues, D. Donnelly-roberts, S. Arneric, 1995 .

Diversity of neuronal nicotinic acetylcholine receptors: lessons from behavior and implications for CNS therapeutics.

S. Arneric, J. Brioni, M. Decker, 1995, Life sciences.

ABT-089 [2-methyl-3-(2-(S)-pyrrolidinylmethoxy)pyridine dihydrochloride]: II. A novel cholinergic channel modulator with effects on cognitive performance in rats and monkeys.

W. J. Jackson, S. Arneric, J. Buccafusco, 1997, The Journal of pharmacology and experimental therapeutics.

Structure-activity studies on 2-methyl-3-(2(S)-pyrrolidinylmethoxy) pyridine (ABT-089): an orally bioavailable 3-pyridyl ether nicotinic acetylcholine receptor ligand with cognition-enhancing properties.

A. D. Rodrigues, D. Donnelly-roberts, S. Arneric, 1997, Journal of medicinal chemistry.

The pharmacology of (-)-nicotine and novel cholinergic channel modulators.

S. Arneric, J. Sullivan, J. Brioni, 1997, Advances in pharmacology.

Effects of intraseptal infusion of muscimol on inhibitory avoidance and spatial learning: Differential effects of pretraining and posttraining administration

J. Brioni, A. Nagahara, J. McGaugh, 1992, Psychobiology.

Structure-activity studies on a series of a 2-aminopyrimidine-containing histamine H4 receptor ligands.

Jill M. Wetter, U. Warrior, M. McPherson, 2008, Journal of medicinal chemistry.

Acrylamide analog as a novel nitric oxide-independent soluble guanylyl cyclase activator.

M. Nakane, J. Brioni, R. Moreland, 2006, Journal of pharmacological sciences.

J. Sullivan, R. Chess-Williams, M. Williams, 2002, Journal of Pharmacology and Experimental Therapeutics.

Molecular characterization of human SUR2-containing K(ATP) channels.

Murali Gopalakrishnan, Paul E. Kroeger, R. Simmer, 2000, Gene.

ATP-sensitive potassium channels regulate in vivo dopamine release in rat striatum.

J. Brioni, J. Sullivan, D. X. Zhu, 1999, Japanese journal of pharmacology.

Antidepressant-Like Effect of D2/3 Receptor-, but not D4 Receptor-Activation in the Rat Forced Swim Test

J. Brioni, M. Decker, G. Fox, 2005, Neuropsychopharmacology.

Comparison of alpha 1-adrenoceptor agonists in canine urethral pressure profilometry and abdominal leak point pressure models.

J. Brioni, A. Hancock, D. Gauvin, 2001, The Journal of urology.

Antagonism of Supraspinal Histamine H3 Receptors Modulates Spinal Neuronal Activity in Neuropathic Rats

J. Brioni, S. McGaraughty, K. Chu, 2012, Journal of Pharmacology and Experimental Therapeutics.

H4 receptor antagonism exhibits anti-nociceptive effects in inflammatory and neuropathic pain models in rats

Jill M. Wetter, J. Brioni, S. Baker, 2010, Pharmacology Biochemistry and Behavior.

Localization of histamine H4 receptors in the central nervous system of human and rat

J. Brioni, R. Bitner, G. Hsieh, 2009, Brain Research.

Role of central and peripheral mGluR5 receptors in post-operative pain in rats

J. Brioni, M. Decker, R. Moreland, 2005, Pain.

Retrograde memory enhancement by diazepam: its relation to anterograde amnesia, and some clinical implications

I. Izquierdo, L. Cahill, J. Brioni, 2004, Psychopharmacology.

Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems

Jill M. Wetter, J. Brioni, M. Decker, 2010, Brain Research.

The biochemical and neurologic basis for the treatment of male erectile dysfunction.

M. Nakane, J. Brioni, R. Moreland, 2001, The Journal of pharmacology and experimental therapeutics.

Nicotinic receptor agonists exhibit anxiolytic-like effects on the elevated plus-maze test.

J. Brioni, M. Decker, A. O'Neill, 1993, European journal of pharmacology.

and Alzheimer's disease

J. Brioni, Jorge D. Brioni, Tim A. Esbenshade, 2010 .

Influence of Separate and Combined Septal and Amygdala Lesions on Memory, Acoustic Startle, Anxiety, and Locomotor Activity in Rats

J. Brioni, M. Decker, P. Curzon, 1995, Neurobiology of Learning and Memory.

Cholinergic channel activators: novel opportunities for the treatment of CNS disorders.

D. Donnelly-roberts, S. Arneric, J. Sullivan, 1995, Proceedings of the Western Pharmacology Society.

K-ATP opener-mediated attenuation of spontaneous bladder contractions in ligature-intact, partial bladder outlet obstructed rats.

J. Sullivan, J. Brioni, J. J. Lynch, 2003, Life sciences.

(S)-3-methyl-5-(1-methyl-2-pyrrolidinyl)isoxazole (ABT 418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: II. In vivo characterization.

J. Sullivan, J. L. Raszkiewicz, J. Brioni, 1994, The Journal of pharmacology and experimental therapeutics.

ABT-418: discriminative stimulus properties and effect on ventral tegmental cell activity

S. Arneric, J. Brioni, M. Decker, 1995, Psychopharmacology.

Diaryldiamines with dual inhibition of the histamine H(3) receptor and the norepinephrine transporter and the efficacy of 4-(3-(methylamino)-1-phenylpropyl)-6-(2-(pyrrolidin-1-yl)ethoxy)naphthalen-1-ol in pain.

Jill M. Wetter, J. Brioni, P. Honore, 2010, Journal of medicinal chemistry.

Picrotoxin enhances latent extinction of conditioned fear.

J. D. McGaugh, J. Brioni, C. Castellano, 1990, Behavioral neuroscience.

Functional Characterization of the Novel Neuronal Nicotinic Acetylcholine Receptor Ligand GTS-21 In Vitro and In Vivo

W. J. Jackson, D. Donnelly-roberts, S. Arneric, 1997, Pharmacology Biochemistry and Behavior.

Involvement of the amygdaloid complex in neuromodulatory influences on memory storage

J. D. McGaugh, L. Cahill, J. Brioni, 1990, Neuroscience & Biobehavioral Reviews.

Effect of intraventricular injections of dihydro-beta-erythroidine (DH,β E) on spatial memory in the rat

J. Brioni, M. Decker, P. Curzon, 1996, Brain Research.

Effects of ABT-418, a novel cholinergic channel ligand, on place learning in septal-lesioned rats.

S. Arneric, J. Brioni, M. Decker, 1994, European journal of pharmacology.

Discovery of Histamine H3 Antagonists for the Treatment of Cognitive Disorders and Alzheimer's Disease

J. Brioni, Tiffany Runyan Garrison, Jorge D Brioni, 2011, Journal of Pharmacology and Experimental Therapeutics.

Dopamine D4 receptors and the regulation of penile erection

J. Brioni, R. Moreland, 2006 .

Activation of dopamine D4 receptors by ABT-724 induces penile erection in rats.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Proceedings of the National Academy of Sciences of the United States of America.

A cell-based microarrayed compound screening format for identifying agonists of G-protein-coupled receptors.

D. Donnelly-roberts, J. Kofron, U. Warrior, 2003, Analytical biochemistry.

Diazepam impairs place learning in the Morris water maze.

J. Brioni, M. Arolfo, 1991, Behavioral and neural biology.

Association of Catsper1 or -2 with Cav3.3 Leads to Suppression of T-type Calcium Channel Activity*

J. Sullivan, J. Brioni, A. Saraf, 2006, Journal of Biological Chemistry.

Decreased reactivity to the anticonflict effect of diazepam in perinatally undernourished rats

J. Brioni, O. Orsingher, N. Córdoba, 1989, Behavioural Brain Research.

Operant behavior and reactivity to the anticonflict effect of diazepam in perinatally undernourished rats

J. Brioni, O. Orsingher, 1988, Physiology & Behavior.

ABT-866, a novel α1A-adrenoceptor agonist with antagonist properties at the α1B- and α1D-adrenoceptor subtypes

J. Sullivan, M. Williams, J. Brioni, 2002 .

Central Mechanisms Regulating Penile Erection in Conscious Rats: The Dopaminergic Systems Related to the Proerectile Effect of Apomorphine

D. Donnelly-roberts, J. Sullivan, J. Brioni, 2004, Journal of Pharmacology and Experimental Therapeutics.

Pharmacological properties of A-204176, a novel and selective alpha1A adrenergic agonist, in in vitro and in vivo models of urethral function.

J. Brioni, M. Williams, D. Gauvin, 2001, Life sciences.

A-315456: a selective α1D-adrenoceptor antagonist with minimal dopamine D2 and 5-HT1A receptor affinity

J. Sullivan, M. Nakane, J. Brioni, 2001 .

Perinatal protein deprivation enhances the anticonflict effect measured after chronic ethanol administration in adult rats.

J. Brioni, O. Orsingher, G. Cuadra, 1992, The Journal of nutrition.

Effects of selective dopamine receptor subtype agonists on cardiac contractility and regional haemodynamics in rats

J. Segreti, J. Brioni, R. Moreland, 2004, Clinical and experimental pharmacology & physiology.

YC-1 potentiates the nitric oxide/cyclic GMP pathway in corpus cavernosum and facilitates penile erection in rats.

J. Sullivan, J. Brioni, R. Moreland, 2003, European journal of pharmacology.

N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine.

J. Sullivan, M. Nakane, M. Williams, 2002, Journal of medicinal chemistry.

Efficient synthesis of the α1D adrenoceptor antagonist A-315456

J. Brioni, S. Buckner, A. Daza, 2003 .

Retention enhancement by pre-test beta-endorphin and oxotremorine and its reversal by scopolamine.

I. Izquierdo, J. Brioni, 1988, Behavioral and neural biology.

Amino acid-derived piperidides as novel CCKB ligands with anxiolytic-like properties

J. Brioni, M. Holladay, M. Stashko, 1995 .

Dopamine D4 receptor signaling in the rat paraventricular hypothalamic nucleus: Evidence of natural coupling involving immediate early gene induction and mitogen activated protein kinase phosphorylation

S. Otte, J. Brioni, M. Decker, 2006, Neuropharmacology.

Discovery of histamine H 3 antagonists for the treatment of cognitive disorders and Alzheimer ’ s disease

J. Brioni, T. Esbenshade, M. Cowart, 2010 .

Nicotinic receptor agonists facilitate retention of avoidance training: participation of dopaminergic mechanisms.

S. Arneric, J. Brioni, Stephen P. Arneric, 1993, Behavioral and neural biology.

cis-4-(Piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine (A-987306), a new histamine H4R antagonist that blocks pain responses against carrageenan-induced hyperalgesia.

Jill M. Wetter, J. Brioni, P. Chandran, 2008, Journal of medicinal chemistry.

Spatial memory impairment induced by lesion of the mesohippocampal dopaminergic system in the rat

J. Brioni, A. Gasbarri, A. Sulli, 1996, Neuroscience.

Potential treatment of Alzheimer disease using cholinergic channel activators (ChCAs) with cognitive enhancement, anxiolytic-like, and cytoprotective properties.

D. Donnelly-roberts, S. Arneric, J. Sullivan, 1995, Alzheimer disease and associated disorders.

Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Journal of medicinal chemistry.

Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.

D. Donnelly-roberts, J. Sullivan, M. Nakane, 2004, Journal of medicinal chemistry.

Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring.

J. Brioni, T. Esbenshade, M. Cowart, 2010, Bioorganic & medicinal chemistry letters.

Perinatal undernutritiom alters hypothermic responses to different central agonists in recovered adult rats

J. Brioni, O. Orsingher, 1987, Neuropharmacology.

Reactivity of amphetamine in perinatally undernourished rats: Behavioral and neurochemical correlates

J. Brioni, O. Orsingher, E. Keller, 1986, Pharmacology Biochemistry and Behavior.

Perinatal undernutrition alters different pharmacological effects of ethanol in adult recovered rats.

J. Brioni, L. A. Pavcovich, O. Orsingher, 1990, Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia.

Linopirdine (DuP996) facilitates the retention of avoidance training and improves performance of septal-lesioned rats in the water maze

S. Arneric, J. Brioni, M. Decker, 1993, Pharmacology Biochemistry and Behavior.

Nicotine cue: lack of effect of the α7 nicotinic receptor antagonist methyllycaconitine

J. Brioni, A. O'Neill, David J. B. Kim, 1996 .

Histological and Behavioral Protection by (−)-Nicotine against Quinolinic Acid-Induced Neurodegeneration in the Hippocampus

J. Brioni, S. Morgan, A. O'Neill, 1998, Neurobiology of Learning and Memory.

Antidepressant-like effect of D(2/3) receptor-, but not D(4) receptor-activation in the rat forced swim test.

J. Brioni, M. Decker, G. Fox, 2005, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

Molecular characterization of human SUR2-containing K(ATP) channels.

M Gopalakrishnan, R. Simmer, J. Sullivan, 2000, Gene.

Rapid hit to lead evaluation of pyrazolo[3,4-d]pyrimidin-4-one as selective and orally bioavailable mGluR1 antagonists.

J. Brioni, R. Moreland, P. Honore, 2007, Bioorganic & medicinal chemistry letters.

The effect of flumazenil on acquisition, retention, and retrieval of spatial information.

I. Izquierdo, J. Medina, J. Brioni, 1991, Behavioral and neural biology.

Isoform dependent differences in histamine H3 receptor constitutive activity revealed by human H3(445) and H3(365) receptors.

J. Brioni, A. Hancock, T. Esbenshade, 2007 .

Effect of flumazenil on the memory‐enhancing properties of (−)‐nicotine in rodents

J. Brioni, A. O'Neill, 1994 .

Effect of intraventricular injections of dihydro-beta-erythroidine (DH beta E) on spatial memory in the rat.

J. Brioni, M. Decker, P. Curzon, 1996, Brain research.

Anxiolytic-like effects of the novel cholinergic channel activator ABT-418.

S. Arneric, J. Brioni, M. Decker, 1994, The Journal of pharmacology and experimental therapeutics.

Nicotine cue: lack of effect of the alpha 7 nicotinic receptor antagonist methyllycaconitine.

J. Brioni, A. O'Neill, D. J. Kim, 1996, European journal of pharmacology.

ABT‐089 [2‐methyl‐3‐(2‐(s)‐pyrrolidinylmethoxy) pyridine dihydrochloride]: Discriminative stimulus properties and electrophysiological actions

S. Arneric, J. Brioni, M. Decker, 1997 .

ABT-418: A Novel Cholinergic Channel Activator (ChCA) for the Potential Treatment of Alzheimer’s Disease

A. D. Rodrigues, S. Arneric, J. Sullivan, 1994 .

ABT — 418, a Novel Nicotinic Agonist

A. D. Rodrigues, W. J. Jackson, Y. Martin, 1994 .

Antinociceptive effects of histamine H3 receptor antagonist in the preclinical models of pain in rats and the involvement of central noradrenergic systems

Jill M. Wetter, J. Brioni, M. Decker, 2010, Brain Research.

Pharmacological characterization of A-960656, a histamine H₃ receptor antagonist with efficacy in animal models of osteoarthritis and neuropathic pain.

Jill M. Wetter, G. Diaz, J. Brioni, 2012, European journal of pharmacology.

Assessment of the abuse liability of ABT-288, a novel histamine H3 receptor antagonist

K. Browman, J. Brioni, J. J. Lynch, 2013, Psychopharmacology.

Pharmacological Properties and Procognitive Effects of ABT-288, a Potent and Selective Histamine H3 Receptor Antagonist

Min Zhang, K. Browman, J. Sullivan, 2012, Journal of Pharmacology and Experimental Therapeutics.

Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist.

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