H. Wanibuchi

发表

Hormesis and dose-response-mediated mechanisms in carcinogenesis: evidence for a threshold in carcinogenicity of non-genotoxic carcinogens.

S. Fukushima, A. Kinoshita, R. Puatanachokchai, 2005, Carcinogenesis.

Enhancement of lung carcinogenesis by nonylphenol and genistein in a F344 rat multiorgan carcinogenesis model.

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Cancer letters.

Formation of 8-hydroxydeoxyguanosine and cell-cycle arrest in the rat liver via generation of oxidative stress by phenobarbital: association with expression profiles of p21(WAF1/Cip1), cyclin D1 and Ogg1.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2002, Carcinogenesis.

Organ-specific, carcinogen-induced increases in cell proliferation in p53-deficient mice.

S. Fukushima, H. Wanibuchi, Y. Okuno, 2000, Cancer research.

Activated Akt expression has significant correlation with EGFR and TGF-alpha expressions in stage I NSCLC.

T. Mukohara, S. Fukushima, H. Wanibuchi, 2004, Anticancer research.

Role of CYP2E1 in thioacetamide-induced mouse hepatotoxicity.

S. Fukushima, H. Wanibuchi, K. Morimura, 2008, Toxicology and applied pharmacology.

Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways.

S. Fukushima, H. Wanibuchi, M. Wei, 2013, Toxicology and applied pharmacology.

Twenty-One Proteins Up-Regulated in Human H-ras Oncogene Transgenic Rat Pancreas Cancers are Up-Regulated in Human Pancreas Cancer

M. Suzui, H. Wanibuchi, T. Sukata, 2013, Pancreas.

Inhibitory effect of Raphanobrassica on Helicobacter pylori-induced gastritis in Mongolian gerbils.

H. Wanibuchi, M. Wei, T. Toyoda, 2014, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Sensitive quantitative assay for point mutations in the rat H-ras gene based on single nucleotide primer extension.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2010, Experimental and therapeutic medicine.

Induction of DNA‐adducts and increase of 8‐hydroxy‐2‐deoxyguanosine, but no development of preneoplastic lesions in offspring liver with transplacental and trans‐breast milk exposure to 2‐amino‐3,8‐dimethylimidazo [4,5‐f]quinoxaline (MelQx) in rats

S. Fukushima, H. Wanibuchi, K. Morimura, 2004, Cancer science.

Lack of mutagenic and toxic effects of low dose potassium bromate on kidneys in the Big Blue rat.

S. Fukushima, H. Wanibuchi, M. Wei, 2008, Mutation research.

Enhancing risk of ethanol on MeIQx-induced rat hepatocarcinogenesis is accompanied with increased levels of cellular proliferation and oxidative stress.

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Cancer letters.

Cytokeratin 8/18 as a new marker of mouse liver preneoplastic lesions.

H. Wanibuchi, M. Wei, Masayo Inoue, 2010, Toxicology and applied pharmacology.

Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident.

S. Fukushima, H. Wanibuchi, K. Morimura, 2009, Carcinogenesis.

Percutaneous carbon dioxide treatment using a gas mist generator enhances the collateral blood flow in the ischemic hindlimb.

H. Wanibuchi, K. Miura, H. Iwao, 2015, Journal of atherosclerosis and thrombosis.

Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats

H. Wanibuchi, Anna Kakehashi, S. Hayashi, 2018, Archives of Toxicology.

A chronic toxicity study of diphenylarsinic acid in F344 rats in drinking water for 52 weeks.

H. Wanibuchi, Kenichiro Doi, Anna Kakehashi, 2017, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

mTOR Activation in Liver Tumors Is Associated with Metabolic Syndrome and Non-Alcoholic Steatohepatitis in Both Mouse Models and Humans

H. Wanibuchi, Anna Kakehashi, M. Fujioka, 2018, Cancers.

Different genetic alterations in rat forestomach tumors induced by genotoxic and non-genotoxic carcinogens.

M. Kaneko, S. Fukushima, H. Wanibuchi, 2002, Carcinogenesis.

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription

M. Oshimura, H. Wanibuchi, M. Osaki, 2019, bioRxiv.

PITX1 protein interacts with ZCCHC10 to regulate hTERT mRNA transcription

M. Oshimura, H. Wanibuchi, M. Osaki, 2016, bioRxiv.

Examination of in vivo mutagenicity of sodium arsenite and dimethylarsinic acid in gpt delta rats.

H. Wanibuchi, Kenichiro Doi, Anna Kakehashi, 2016, Journal of environmental sciences.

Induction of glutathione S-transferase placental form positive foci in liver and epithelial hyperplasia in urinary bladder, but no tumor development in male Fischer 344 rats treated with monomethylarsonic acid for 104 weeks.

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Toxicology and applied pharmacology.

Promotion by Sodium L‐Ascorbate in Rat Two‐stage Urinary Bladder Carcinogenesis is Dependent on the Interval of Administration

S. Fukushima, H. Wanibuchi, Shinji Yamamoto, 1999, Japanese journal of cancer research : Gann.

Long-term administration of excess zinc impairs learning and memory in aged mice.

H. Wanibuchi, Isao Teramoto, Kaoru Yoshida, 2019, The Journal of toxicological sciences.

SIRT2 knockdown increases basal autophagy and prevents postslippage death by abnormally prolonging the mitotic arrest that is induced by microtubule inhibitors

M. Oshimura, H. Wanibuchi, Yanze Li, 2014, The FEBS journal.

Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features.

S. Fukushima, H. Wanibuchi, K. Morimura, 1998, Cancer.

Modifying effects of 1,2-dichloropropane on N-nitrosobis(2-oxopropyl)amine-induced cholangiocarcinogenesis in male Syrian hamsters.

H. Wanibuchi, Masayuki Kanki, Anna Kakehashi, 2015, The Journal of toxicological sciences.

Effects of pioglitazone, a peroxisome proliferator-activated receptor gamma agonist, on the urine and urothelium of the rat.

Samuel M. Cohen, H. Wanibuchi, M. Wei, 2010, Toxicological sciences : an official journal of the Society of Toxicology.

Prevention of Urinary Bladder Cancer: The Interface Between Experimental and Human Studies.

S. Fukushima, H. Wanibuchi, 2000, Asian Pacific journal of cancer prevention : APJCP.

Dose-dependent induction of aberrant crypt foci in the colons but no neoplastic lesions in the livers of heterozygous p53-deficient mice treated with low dose 2-amino-3-methylimidazo [4,5-f]quinoline.

S. Fukushima, H. Wanibuchi, K. Morimura, 1999, Cancer letters.

Thallium and FDG uptake by atelectasis with bronchogenic carcinoma

M. Shakudo, H. Wanibuchi, J. Kawabe, 1999, Annals of nuclear medicine.

Two cases of maxillary cancer with a similar clinical course and imaging findings but markedly different levels of FDG uptake.

H. Wanibuchi, S. Higashiyama, J. Kawabe, 2005, Clinical nuclear medicine.

Two cases of chronic tonsillitis studied by FDG-PET

M. Shakudo, R. Yamada, H. Wanibuchi, 1999, Annals of nuclear medicine.

Lack of Inhibitory Effects of Coumaperine from Pepper on the Promotion Stage of Chemical Hepatocarcinogenesis in the Rat

S. Fukushima, H. Wanibuchi, K. Morimura, 2003 .

Food Restriction Inhibits the Growth of Intestinal Polyps in Multiple Intestinal Neoplasia Mouse

S. Hayashi, S. Fukushima, H. Wanibuchi, 2002, Japanese journal of cancer research : Gann.

Low-dose-dependent carcinogenic potential of 2-amino-3-methylimidazo[4,5-f]quinoline in the immunodeficient (SCID) mouse colon.

S. Fukushima, H. Wanibuchi, K. Morimura, 1999, Nutrition and cancer.

Alpha-benzene hexachloride exerts hormesis in preneoplastic lesion formation of rat hepatocarcinogenesis with the possible role for hepatic detoxifying enzymes.

S. Fukushima, A. Kinoshita, R. Puatanachokchai, 2006, Cancer letters.

Novel medium‐term carcinogenesis model for lung squamous cell carcinoma induced by N‐nitroso‐tris‐chloroethylurea in mice

H. Wanibuchi, M. Wei, S. Yamano, 2013, Cancer science.

Expression, intracellular localization, and mutation of EGFR in conjunctival squamous cell carcinoma and the association with prognosis and treatment

H. Wanibuchi, S. Honda, A. Azumi, 2020, PloS one.

Urinary Bladder Lesions after the Chernobyl Accident: Immunohistochemical Assessment of p53, Proliferating Cell Nuclear Antigen, Cyclin D1 and p21WAF1/Cip1

S. Fukushima, H. Wanibuchi, Shinji Yamamoto, 1999, Japanese journal of cancer research : Gann.

Carcinogenicity of dimethylarsinic acid in p53 heterozygous knockout and wild-type C57BL/6J mice.

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Carcinogenesis.

Urinary bladder carcinogenicity of dimethylarsinic acid in male F344 rats.

Wei Li, S. Fukushima, H. Wanibuchi, 1999, Carcinogenesis.

Promotion of Rat Hepatocarcinogenesis by Dimethylarsinic Acid: Association with Elevated Ornithine Decarboxylase Activity and Formation of 8‐Hydroxydeoxyguanosine in the Liver

S. Fukushima, H. Wanibuchi, Y. Yano, 1997, Japanese journal of cancer research : Gann.

Promoting effects of dimethylarsinic acid on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in rats.

S. Fukushima, H. Wanibuchi, S. Yamamoto, 1996, Carcinogenesis.

Evaluation of the Modifying Effect of Inhalation of Mainstream Cigarette Smoke on Mouse Bladder Carcinogenesis

H. Wanibuchi, M. Wei, S. Yamano, 2013, Journal of toxicologic pathology.

Dose‐dependence of promotion of 2‐amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline‐induced rat hepatocarcinogenesis by ethanol: Evidence for a threshold

S. Fukushima, A. Kinoshita, R. Puatanachokchai, 2005, Cancer science.

Clinical relevance of tertiary lymphoid structures in esophageal squamous cell carcinoma

H. Wanibuchi, Shugo Suzuki, M. Ohira, 2022, BMC cancer.

Canopy Homolog 2 as a Novel Molecular Target in Hepatocarcinogenesis

H. Wanibuchi, M. Shiota, Shugo Suzuki, 2021, Cancers.

Long-term treatment with L-isoleucine or L-leucine in AIN-93G diet has promoting effects on rat bladder carcinogenesis.

H. Wanibuchi, M. Wei, S. Yamano, 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Enhancement by estradiol 3-benzoate in thioacetamide-induced liver cirrhosis of rats.

A. Hagihara, S. Seki, S. Fukushima, 2005, Toxicological sciences : an official journal of the Society of Toxicology.

Urinary bladder lesions induced by persistent chronic low‐dose ionizing radiation

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2003, Cancer science.

FOXP3/CD8 ratio and CXCR4-positive regulatory T cells as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment

H. Wanibuchi, A. Azumi, M. Tagami, 2021 .

A chronic toxicity study of diphenylarsinic acid in the drinking water of C57BL/6J mice for 52 weeks

H. Wanibuchi, M. Fujioka, Takashi Yamaguchi, 2019, Journal of toxicologic pathology.

Cell Proliferation of Rat Bladder Urothelium Induced by Nicotine is Suppressed by the NADPH Oxidase Inhibitor, Apocynin.

Samuel M. Cohen, H. Wanibuchi, A. Naiki‐Ito, 2020, Toxicology letters.

Methionine Sulfoxide Stimulates Hepatocarcinogenesis in Non-alcoholic Steatohepatitis (NASH) Mouse: Possible Role of Free Radical-mediated DNA Methylation

H. Wanibuchi, T. Norimura, A. Ootsuyama, 2012 .

Cytokeratin 8/18 overexpression and complex formation as an indicator of GST-P positive foci transformation into hepatocellular carcinomas

S. Fukushima, H. Wanibuchi, M. Wei, 2009, Toxicology and Applied Pharmacology.

Metabolites of arsenobetaine in rats : does decomposition of arsenobetaine occur in mammals?

S. Fukushima, H. Wanibuchi, Y. Inoue, 2001 .

Urinary sulfur-containing metabolite produced by intestinal bacteria following oral administration of dimethylarsinic acid to rats.

S. Fukushima, H. Wanibuchi, Y. Inoue, 2003, Chemical research in toxicology.

Inhibitory effects of 1,3-diaminopropane, an ornithine decarboxylase inhibitor, on rat two-stage urinary bladder carcinogenesis initiated by N-butyl-N-(4-hydroxybutyl)nitrosamine.

S. Fukushima, H. Wanibuchi, K. Morimura, 2000, Carcinogenesis.

p53 and H‐ras Mutations and Microsatellite Instability in Renal Pelvic Carcinomas of NON/Shi Mice Treated with N‐Butyl‐N‐(4‐hydroxybutyl)‐nitrosamine: Different Genetic Alteration from Urinary Bladder Carcinoma

S. Fukushima, H. Wanibuchi, K. Morimura, 2001, Japanese journal of cancer research : Gann.

Infrequent involvement of microsatellite instability in urinary bladder carcinomas of the NON/Shi mouse treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

S. Fukushima, H. Wanibuchi, S. Yamamoto, 1998, Cancer letters.

S‐Methylcysteine and Cysteine Are Inhibitors of Induction of Glutathione S‐Transferase Placental Form‐positive Foci during Initiation and Promotion Phases of Rat Hepatocarcinogenesis

S. Fukushima, H. Wanibuchi, Y. Yano, 1997, Japanese journal of cancer research : Gann.

Elevation of 8-hydroxydeoxyguanosine and cell proliferation via generation of oxidative stress by organic arsenicals contributes to their carcinogenicity in the rat liver and bladder.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2007, Toxicology and applied pharmacology.

Promoting effects of monomethylarsonic acid, dimethylarsinic acid and trimethylarsine oxide on induction of rat liver preneoplastic glutathione S‐transferase placental form positive foci: A possible reactive oxygen species mechanism

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2002, International journal of cancer.

Lack of change in the levels of liver and kidney cytochrome P-450 isozymes in p53+/- knockout mice treated with N-butyl-N-(4-hydroxybutyl)nitrosamine.

S. Fukushima, H. Wanibuchi, A. Koide, 2001, Mutagenesis.

Inhibition of liver glutathione S-transferase placental form-positive foci development in the rat hepatocarcinogenesis by Porphyra tenera (Asakusa-nori).

S. Fukushima, H. Wanibuchi, S. Imaoka, 1999, Cancer letters.

No inhibitory effects of (-)-epigallocatechin gallate and lycopene on spontaneous hepatotumorigenesis in C3H/HeN mice.

T. Ishikawa, H. Wanibuchi, S. Mori, 2010, Fukushima journal of medical science.

Characteristic Upregulation of Glucose-Regulated Protein 78 in an Early Lesion Negative for Hitherto Established Cytochemical Markers in Rat Hepatocarcinogenesis

S. Fukushima, Masahiko Kushida, H. Wanibuchi, 2009, Journal of Toxicologic Pathology.

Hormesis in Carcinogenicity of Non-genotoxic Carcinogens

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2006 .

Hormesis in Chemical Carcinogenesis Threshold in Carcinogenicity of Environmental Carcinogens

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2006 .

Urinary excretion of arsenic metabolites after long-term oral administration of various arsenic compounds to rats.

S. Fukushima, H. Wanibuchi, Y. Inoue, 1998, Journal of toxicology and environmental health. Part A.

Elevation of urinary enzyme levels in rat bladder carcinogenesis.

S. Fukushima, H. Wanibuchi, E. Salim, 1999, Carcinogenesis.

Immunohistochemical and quantitative analysis of cellular and extracellular components of aortic atherosclerosis in WHHL rabbits.

H. Wanibuchi, M. Shiomi, T. Ito, 1994, Journal of atherosclerosis and thrombosis.

Is the Watanabe heritable hyperlipidemic rabbit a suitable experimental model for percutaneous transluminal coronary angioplasty in humans? A light microscopic, immunohistochemical and ultrastructural study.

A. Becker, H. Wanibuchi, K. Dingemans, 1993, Journal of the American College of Cardiology.

The response to percutaneous transluminal coronary angioplasty: An ultrastructural study of smooth muscle cells and endothelial cells.

A. Becker, H. Wanibuchi, K. Dingemans, 1992, Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology.

Oxidative Stress in the Carcinogenicity of Chemical Carcinogens

S. Fukushima, H. Wanibuchi, M. Wei, 2013, Cancers.

Effects of cessation of alcohol exposure on rat hepatocarcinogenesis.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2006, Asian Pacific journal of cancer prevention : APJCP.

Possible prevention by abieslactone of development of diethylnitrosamine-initiated GST-P positive foci in the rat liver.

S. Seki, S. Fukushima, H. Wanibuchi, 2001, Teratogenesis, carcinogenesis, and mutagenesis.

Dose-dependent inhibition of glutathione S-transferase placental form-positive hepatocellular foci induction in the rat by methyl propyl disulfide and propylene sulfide from garlic and onions.

S. Fukushima, H. Wanibuchi, Y. Yano, 1994, Cancer letters.

Cache Domain Containing 1 Is a Novel Marker of Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis

H. Wanibuchi, Shugo Suzuki, R. Wongpoomchai, 2021, Cancers.

Accumulation of 8-hydroxydeoxyguanosine, L-arginine and Glucose Metabolites by Liver Tumor Cells Are the Important Characteristic Features of Metabolic Syndrome and Non-Alcoholic Steatohepatitis-Associated Hepatocarcinogenesis

H. Wanibuchi, Shugo Suzuki, V. Stefanov, 2020, International journal of molecular sciences.

Revised rat multi-organ carcinogenesis bioassay for whole-body detection of chemopreventive agents: modifying potential of S-methylcysteine.

S. Fukushima, H. Wanibuchi, S. Kudoh, 2004, Cancer letters.

Suppression of chemical carcinogenesis by water-soluble organosulfur compounds.

S. Fukushima, H. Wanibuchi, M. Ogawa, 2001, The Journal of nutrition.

Inhibitory Effects of S‐Methylcysteine and Cysteine on the Promoting Potential of Sodium Phenobarbital on Rat Liver Carcinogenesis

S. Fukushima, H. Wanibuchi, Y. Yano, 2000, Japanese journal of cancer research : Gann.

Cancer prevention by organosulfur compounds from garlic and onion

S. Fukushima, H. Wanibuchi, N. Takada, 1997, Journal of cellular biochemistry. Supplement.

Di-n-butyl Phthalate is Toxic to the Male Reproductive System and Its Toxicity is Enhanced by Thioacetamide Induced Liver Injury

S. Hayashi, S. Fukushima, H. Wanibuchi, 2004 .

Progression of Hepatic Adenoma to Carcinoma in Ogg1 Mutant Mice Induced by Phenobarbital

S. Fukushima, H. Wanibuchi, M. Fujioka, 2017, Oxidative medicine and cellular longevity.

Enhanced Susceptibility of Ogg1 Mutant Mice to Multiorgan Carcinogenesis

H. Wanibuchi, M. Fujioka, Naomi Ishii, 2017, International journal of molecular sciences.

Carcinogenicity of dimethylarsinic acid in Ogg1‐deficient mice

T. Noda, S. Fukushima, A. Kinoshita, 2007, Cancer science.

Qualitative and Quantitative Assessments on Low-Dose Carcinogenicity of Genotoxic Hepatocarcinogens: Dose–Response for Key Events in Rat Hepatocarcinogenesis

S. Fukushima, H. Wanibuchi, M. Gi, 2016 .

Dimethylarsinic acid induces 8-hydroxy-2'-deoxyguanosine formation in the kidney of NCI-Black-Reiter rats.

S. Fukushima, H. Wanibuchi, C. Masuda, 2001, Cancer letters.

Lack of Promoting Potential of Dimethylarsinic Acid in the Kidney of Male NCI-Black Reiter Rats

S. Fukushima, H. Wanibuchi, Y. Konishi, 2000 .

Induction of tumors in the colon and liver of the immunodeficient (SCID) mouse by 2-amino-3-methylimidazo[4,5-f ]quinoline (IQ)-modulation by long-chain fatty acids.

S. Fukushima, H. Wanibuchi, K. Morimura, 2002, Carcinogenesis.

p53 Status in Multiple Human Urothelial Cancers: Assessment for Clonality by the Yeast p53 Functional Assay in Combination with p53 Immunohistochemistry

S. Fukushima, H. Wanibuchi, M. Tada, 2000, Japanese journal of cancer research : Gann.

Specific p53 gene mutations in urinary bladder epithelium after the Chernobyl accident.

S. Fukushima, H. Wanibuchi, K. Morimura, 1999, Cancer research.

Enhancement of urinary bladder carcinogenesis in nullizygous p53-deficient mice by N-butyl-N-(4-hydroxybutyl)nitrosamine.

S. Fukushima, H. Wanibuchi, E. Salim, 1999, Cancer Letters.

Diphenylarsinic acid exerts promotion effects on hepatobiliary carcinogenesis in a rat medium-term multiorgan carcinogenicity bioassay

H. Wanibuchi, S. Yamano, M. Fujioka, 2016, Journal of toxicologic pathology.

Enhanced Urinary Bladder, Liver and Colon Carcinogenesis in Zucker Diabetic Fatty Rats in a Multiorgan Carcinogenesis Bioassay: Evidence for Mechanisms Involving Activation of PI3K Signaling and Impairment of p53 on Urinary Bladder Carcinogenesis

H. Wanibuchi, M. Wei, M. Inaba, 2011, Journal of toxicologic pathology.

Post-initiation inhibition of MeIQx hepatocarcinogenesis in rats by cysteine.

S. Fukushima, H. Wanibuchi, K. Wakabayashi, 2003, Osaka city medical journal.

Lack of promoting effect due to oral administration of dimethylarsinic acid on rat lung carcinogenesis initiated with N-bis(2-hydroxypropyl)nitrosamine.

S. Fukushima, H. Wanibuchi, K. Morimura, 2002, Cancer letters.

Chemopreventive effects of S-methylcysteine on rat hepatocarcinogenesis induced by concurrent administration of sodium nitrite and morpholine.

S. Fukushima, H. Wanibuchi, K. Morimura, 2000, Cancer letters.

Chemopreventive Effects of Bovine Lactoferrin on N‐Butyl‐N‐(4‐ hydroxybutyl)nitrosamine‐induced Rat Bladder Carcinogenesis

S. Fukushima, H. Wanibuchi, C. Masuda, 2000, Japanese journal of cancer research : Gann.

Inhibition by Ginseng of 1,2-Dimethylhydrazine Induction of Aberrant Crypt Foci in the Rat Colon

S. Fukushima, H. Wanibuchi, M. Wei, 2000, Nutrition and cancer.

LOH and mutational analysis of p53 alleles in mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl) nitrosamine.

S. Fukushima, H. Wanibuchi, K. Morimura, 1999, Carcinogenesis.

High susceptibility of p53(+/-) knockout mice in N-butyl-N-(4-hydroxybutyl)nitrosamine urinary bladder carcinogenesis and lack of frequent mutation in residual allele.

S. Fukushima, H. Wanibuchi, A. Yoshitake, 1998, Cancer research.

Promotion of chemically induced rat esophageal tumorigenesis with post-initiation ethanol modification.

M. Kaneko, S. Fukushima, H. Wanibuchi, 2001, Teratogenesis, carcinogenesis, and mutagenesis.

AGR2 as a potential biomarker of human lung adenocarcinoma.

H. Wanibuchi, M. Wei, S. Suehiro, 2012, Osaka city medical journal.

Critical Role of Angiotensin II in Excess Salt-Induced Brain Oxidative Stress of Stroke-Prone Spontaneously Hypertensive Rats

H. Wanibuchi, H. Iwao, Y. Izumi, 2005, Stroke.

Detection of non-genotoxic hepatocarcinogens and prediction of their mechanism of action in rats using gene marker sets.

H. Wanibuchi, Masayuki Kanki, M. Fujioka, 2016, The Journal of toxicological sciences.

Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis

S. Fukushima, H. Wanibuchi, K. Morimura, 2008, International journal of cancer.

Mitochondrial prohibitins and septin 9 are implicated in the onset of rat hepatocarcinogenesis.

S. Fukushima, H. Wanibuchi, M. Wei, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

Significance of cyclin D1 overexpression in transitional cell carcinomas of the urinary bladder and its correlation with histopathologic features

S. Fukushima, H. Wanibuchi, K. Morimura, 1997, Cancer.

The carbonic anhydrase inhibitor acetazolamide inhibits urinary bladder cancers via suppression of β‐catenin signaling

H. Wanibuchi, Shugo Suzuki, J. Uchida, 2022, Cancer science.

OTUD1 deubiquitylase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

H. Wanibuchi, M. Shiota, H. Kosako, 2021 .

CD44 variant 9 is a potential biomarker of tumor initiating cells predicting survival outcome in hepatitis C virus‐positive patients with resected hepatocellular carcinoma

H. Saya, H. Wanibuchi, E. Sugihara, 2016, Cancer science.

Persistent elevation of lysophosphatidylcholine promotes radiation brain necrosis with microglial recruitment by P2RX4 activation

M. Setou, S. Miyatake, H. Wanibuchi, 2022, Scientific Reports.

OTUD1 deubiquitinase regulates NF-κB- and KEAP1-mediated inflammatory responses and reactive oxygen species-associated cell death pathways

H. Wanibuchi, H. Kosako, Hirotaka Takahashi, 2022, Cell Death & Disease.

Chapter 16 – Carcinogenicity of dimethylarsinic acid and relevant mechanisms

S. Fukushima, H. Wanibuchi, K. Morimura, 2003 .

Involvement of ubiquitination and sumoylation in bladder lesions induced by persistent long-term low dose ionizing radiation in humans.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2006, The Journal of urology.

Jun Shen

S. Fukushima, H. Wanibuchi, M. Wei, 2004 .

2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) promotes mouse hepatocarcinogenesis by activating transforming growth factor-β and Wnt/β-catenin signaling pathways.

H. Wanibuchi, M. Wei, S. Yamano, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Tumor-associated MUC5AC stimulates in vivo tumorigenicity of human pancreatic cancer.

H. Wanibuchi, T. Sawada, K. Hirakawa, 2011, International journal of oncology.

Chemopreventive Action by Ethanol-extracted Brazilian Green Propolis on Post-initiation Phase of Inflammation-associated Rat Colon Tumorigenesis.

H. Wanibuchi, Kenichiro Doi, M. Fujioka, 2017, In vivo.

Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice

S. Fukushima, H. Wanibuchi, K. Morimura, 2000, Japanese journal of cancer research : Gann.

B cells in tertiary lymphoid structures are associated with favorable prognosis in gastric cancer.

H. Wanibuchi, K. Hirakawa, M. Ohira, 2017, The Journal of surgical research.

Chemopreventive Effects of Coumaperine from Pepper on the Initiation Stage of Chemical Hepatocarcinogenesis in the Rat

S. Hayashi, S. Fukushima, H. Wanibuchi, 2000, Japanese journal of cancer research : Gann.

MUC5AC protects pancreatic cancer cells from TRAIL-induced death pathways.

H. Wanibuchi, T. Sawada, K. Hirakawa, 2013, International journal of oncology.

Establishment and characterization of a human colonic mucinous carcinoma cell line with predominant goblet‐cell differentiation from liver metastasis

M. Tatematsu, S. Fukushima, H. Wanibuchi, 2005, Pathology international.

Evaluation of the toxicity of mastic gum with 13 weeks dietary administration to F344 rats.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2007, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats

S. Fukushima, H. Wanibuchi, T. Nohmi, 2018, Archives of Toxicology.

In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats

S. Fukushima, H. Wanibuchi, T. Nohmi, 2018, Archives of Toxicology.

Persistence of Liver Cirrhosis in Association with Proliferation of Nonparenchymal Cells and Altered Location of α-Smooth Muscle Actin-Positive Cells

S. Fukushima, H. Wanibuchi, K. Morimura, 2005, Toxicologic pathology.

Neovascularization in the Development of Epithelial Proliferative Lesions of the Rat Urinary Bladder: A Light Microscopic, Immunohistochemical and Ultrastructural Study

S. Fukushima, H. Wanibuchi, Shinji Yamamoto, 1997 .

Epithelial cell clusters of distal convoluted tubules in end-stage chronic glomerulonephritis.

H. Wanibuchi, M. Ueda, T. Fujimoto, 1990, The Tohoku journal of experimental medicine.

The Journal of Toxicological Sciences

H. Wanibuchi, M. Wei, Yiguo Jiang, 2012 .

Effects of pinocembrin on the initiation and promotion stages of rat hepatocarcinogenesis.

S. Fukushima, H. Wanibuchi, R. Wongpoomchai, 2012, Asian Pacific journal of cancer prevention : APJCP.

Expression of epidermal growth factor receptor (EGFR) and downstream-activated peptides in surgically excised non-small-cell lung cancer (NSCLC).

T. Mukohara, S. Fukushima, H. Wanibuchi, 2003, Lung cancer.

Steroid sulfatase promotes invasion through epithelial-mesenchymal transition and predicts the progression of bladder cancer

H. Wanibuchi, T. Nakatani, S. Tamada, 2018, Experimental and therapeutic medicine.

Ingestion of Hijiki seaweed and risk of arsenic poisoning

H. Wanibuchi, Y. Inoue, K. Yamanaka, 2006 .

Promotion of NCI-Black-Reiter male rat bladder carcinogenesis by dimethylarsinic acid an organic arsenic compound.

Wei Li, S. Fukushima, H. Wanibuchi, 1998, Cancer letters.

Microbial metabolite of dimethylarsinic acid is highly toxic and genotoxic.

S. Fukushima, H. Wanibuchi, Kaoru Yoshida, 2004, Toxicology and applied pharmacology.

Metabolism of dimethylarsinic acid in rats: production of unidentified metabolites in vivo

S. Fukushima, H. Wanibuchi, Y. Inoue, 2001 .

Liver tumorigenicity of trimethylarsine oxide in male Fischer 344 rats--association with oxidative DNA damage and enhanced cell proliferation.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2003, Carcinogenesis.

Carcinogenicity of dimethylarsinic acid in male F344 rats and genetic alterations in induced urinary bladder tumors.

S. Fukushima, H. Wanibuchi, K. Morimura, 2002, Carcinogenesis.

Enteric bacteria may play a role in mammalian arsenic metabolism

S. Fukushima, H. Wanibuchi, Kaoru Yoshida, 2001 .

Possible carcinogenic potential of dimethylarsinic acid as assessed in rat in vivo models: a review.

S. Fukushima, H. Wanibuchi, S. Yamamoto, 1997, Mutation research.

Methylation and Demethylation of Dimethylarsinic Acid in Rats Following Chronic Oral Exposure

S. Fukushima, H. Wanibuchi, Y. Inoue, 1996 .

Understanding arsenic carcinogenicity by the use of animal models.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2004, Toxicology and applied pharmacology.

Loss of Heterozygosity in (Lewis×F344)F1 Rat Urinary Bladder Tumors Induced with N‐Butyl‐N‐(4‐hydroxybutyl)nitrosamine Followed by Dimethylarsinic Acid or Sodium L‐Ascorbate

S. Fukushima, H. Wanibuchi, Shinji Yamamoto, 1999, Japanese journal of cancer research : Gann.

Differences of Promoting Activity and Loss of Heterozygosity Between Dimethylarsinic Acid and Sodium L-ascorbate in F1 Rat Urinary Bladder Carcinogenesis

S. Fukushima, H. Wanibuchi, Shinji Yamamoto, 1999 .

The Urinary Excretion of Arsenic Metabolites After a Single Oral Administration of Dimethylarsinic Acid to Rats

S. Fukushima, H. Wanibuchi, Kayo Yoshida, 1997, Archives of environmental contamination and toxicology.

Significant overexpression of metallothionein and cyclin D1 and apoptosis in the early process of rat urinary bladder carcinogenesis induced by treatment with N-butyl-N-(4-hydroxybutyl)nitrosamine or sodium L-ascorbate.

S. Fukushima, H. Wanibuchi, K. Suzuki, 2000, Carcinogenesis.

Cyclin D1 overexpression in rat two-stage bladder carcinogenesis and its relationship with oncogenes, tumor suppressor genes, and cell proliferation.

S. Fukushima, H. Wanibuchi, S. Yamamoto, 1997, Cancer research.

Modulation of Cytochrome P 450 Expression by Kojic Acid in Rats

S. Fukushima, H. Wanibuchi, J. Kang, 2015 .

Non-genotoxic mode of action and possible threshold for hepatocarcinogenicity of Kojic acid in F344 rats.

S. Fukushima, H. Wanibuchi, M. Wei, 2011, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Determination of trivalent methylated arsenicals in rat urine by liquid chromatography-inductively coupled plasma mass spectrometry after solvent extraction.

S. Fukushima, H. Wanibuchi, Kaoru Yoshida, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Effects of dietary cysteine and enteromicroorganisms on metabolism of arsenic

H. Wanibuchi, Kaoru Yoshida, G. Endo, 2004 .

Arsenic exposure and its health effects and risk of cancer in developing countries: micronutrients as host defence.

S. Fukushima, H. Wanibuchi, J. Anetor, 2007, Asian Pacific journal of cancer prevention : APJCP.

Dimethylarsinic acid (DMA) enhanced lung carcinogenesis via histone H3K9 modification in a transplacental mouse model

H. Wanibuchi, Shugo Suzuki, M. Fujioka, 2020, Archives of Toxicology.

Possible rare involvement of O6-methylguanine formation as a significant mutational factor in mouse urinary bladder carcinogenesis models.

S. Fukushima, T. Ishikawa, H. Wanibuchi, 1998, Teratogenesis, carcinogenesis, and mutagenesis.

A comparative study of the sub-chronic toxic effects of three organic arsenical compounds on the urothelium in F344 rats; gender-based differences in response.

S. Fukushima, A. Kinoshita, H. Wanibuchi, 2006, Toxicology and applied pharmacology.

A carcinogenicity study of diphenylarsinic acid in F344 rats in drinking water for 104 weeks.

H. Wanibuchi, Kenichiro Doi, M. Fujioka, 2017, The Journal of toxicological sciences.

Diphenylarsinic acid, a chemical warfare-related neurotoxicant, promotes liver carcinogenesis via activation of aryl hydrocarbon receptor signaling and consequent induction of oxidative DNA damage in rats.

H. Wanibuchi, M. Wei, S. Yamano, 2013, Toxicology and applied pharmacology.

Evaluation of initiation activity of dimethylarsinic acid: Initiation potential of rat hepatocarcinogenesis

S. Fukushima, H. Wanibuchi, J. Kang, 2009 .

Genotoxicity of dimethylarsinous acid: high induction of tetraploids

S. Fukushima, H. Wanibuchi, Kaoru Yoshida, 2005 .

Oral administration of diphenylarsinic acid, a degradation product of chemical warfare agents, induces oxidative and nitrosative stress in cerebellar Purkinje cells.

H. Wanibuchi, S. Okada, M. Hoshino, 2007, Life sciences.

Lack of Promotion Effects of Sodium L-Ascorbate on Urinary Bladder Carcinogenesis in NCI-Black-Reiter (NBR) Male Rats Initiated with N-Butyl-N-(4-Hydroxybutyl) Nitrosamine

S. Fukushima, H. Wanibuchi, S. Uwagawa, 1997 .

Strain Differences in Sensitivity to the Promoting Effect of Sodium L‐Ascorbate in a Two‐stage Rat Urinary Bladder Carcinogenesis Model

S. Fukushima, H. Wanibuchi, A. Takashima, 1997, Japanese journal of cancer research : Gann.

SIGNIFICANT INDUCTION OF EPITHELIAL CELL PROLIFERATION IN THE URINARY BLADDERS OF NCI-BLACK-REITER MALE RATS BY N-BUTYL-N-(4-HYDROXYBUTYL) NITROSAMINE

S. Fukushima, H. Wanibuchi, A. Yoshitake, 1995 .

Expression of thrombospondin-1 in conjunctival squamous cell carcinoma is correlated to the Ki67 index and associated with progression-free survival

H. Wanibuchi, S. Honda, A. Azumi, 2021, Graefe's Archive for Clinical and Experimental Ophthalmology.

Prognostic significance of the MIB‐1 proliferation index for patients with squamous cell carcinoma of the esophagus

S. Fukushima, H. Wanibuchi, Tomoyuki Watanabe, 1995, Cancer.

A Comparative Study of Clinicopathological Features Between Simple Bone Cysts of the Calcaneus and the Long Bone

H. Wanibuchi, Hiroaki Nakamura, J. Takada, 2014, Foot & ankle international.

Possible tumor development from double positive foci for TGF‐alpha and GST‐P observed in early stages on rat hepatocarcinogenesis

Masanori Kato, S. Fukushima, H. Wanibuchi, 2006, Cancer science.

Pueraria mirifica Exerts Estrogenic Effects in the Mammary Gland and Uterus and Promotes Mammary Carcinogenesis in Donryu Rats

H. Wanibuchi, Midori Yoshida, Naomi Ishii, 2016, Toxins.

Characterization of Multinuclear Hepatocytes Induced in Rats by Mitemcinal (GM-611), an Erythromycin Derivative

S. Ōmura, S. Hayashi, H. Wanibuchi, 2008, Toxicologic pathology.

Myeloid-derived suppressor cells are essential partners for immune checkpoint inhibitors in the treatment of cisplatin-resistant bladder cancer.

H. Wanibuchi, T. Nakatani, S. Tamada, 2020, Cancer letters.

Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2.

H. Aburatani, M. Nakao, S. Yachida, 2019, Cell reports.

Serum AGR2 as an early diagnostic and postoperative prognostic biomarker of human lung adenocarcinoma.

H. Wanibuchi, M. Wei, S. Suehiro, 2011, Cancer biomarkers : section A of Disease markers.

Morphological Changes in Silver-stained Nucleolar Organizer Regions (AgNORs) Related to Proliferative Activity in Glutathione S-transferase Placental Form (GST-P) Positive Foci of Rat Liver

S. Fukushima, H. Wanibuchi, K. Morimura, 2000 .

Increased susceptibility to spontaneous lung cancer in mice lacking LIM‐domain only 7

J. Miyoshi, H. Wanibuchi, M. Wei, 2009, Cancer science.

Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line.

H. Wanibuchi, K. Miura, H. Iwao, 2013, International journal of oncology.

Establishment of neutralizing rat monoclonal antibodies for fibroblast growth factor-2.

Y. Ohkawa, H. Wanibuchi, K. Miura, 2014, Monoclonal antibodies in immunodiagnosis and immunotherapy.

Targeted Proteomics of Isolated Glomeruli from the Kidneys of Diabetic Rats: Sorbin and SH3 Domain Containing 2 Is a Novel Protein Associated with Diabetic Nephropathy

H. Wanibuchi, M. Wei, M. Inaba, 2011, Experimental diabetes research.

Altered Gene Expression in Rat Colonic Adenocarcinomas Induced in an Azoxymethane plus 2-Amino-1-Methyl-6-Phenylimidazo[4,5-b]- Pyridine Initiation-Promotion Model

A. Hagihara, S. Fukushima, H. Wanibuchi, 2008, Oncology.

Lack of large intestinal carcinogenicity of 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine at low doses in rats initiated with azoxymethane

S. Fukushima, H. Wanibuchi, K. Morimura, 2005, International journal of cancer.

Genetic instability and p53 mutations in metastatic foci of mouse urinary bladder carcinomas induced by N-butyl-N-(4-hydroxybutyl)nitrosamine.

M. Tatematsu, S. Fukushima, H. Wanibuchi, 1997, Carcinogenesis.

Integrative analyses of miRNA and proteomics identify potential biological pathways associated with onset of pulmonary fibrosis in the bleomycin rat model.

Masahiko Kushida, H. Wanibuchi, K. Sumida, 2015, Toxicology and applied pharmacology.

Tertiary lymphoid structures show infiltration of effective tumor‐resident T cells in gastric cancer

H. Wanibuchi, Shugo Suzuki, M. Ohira, 2021, Cancer science.

Reduced expression of the CDK inhibitor p27(KIP1) in rat two-stage bladder carcinogenesis and its association with expression profiles of p21(WAF1/Cip1) and p53.

S. Fukushima, H. Wanibuchi, S. Yamamoto, 1999, Carcinogenesis.

PIK3CA mutation as a distinctive genetic feature of non-small cell lung cancer with chronic obstructive pulmonary disease: A comprehensive mutational analysis from a multi-institutional cohort.

H. Saka, A. Kubo, H. Wanibuchi, 2017, Lung cancer.

Lack of a Dose‐response Relationship for Carcinogenicity in the Rat Liver with Low Doses of 2‐Amino‐3,8‐dimethylimidazo[4,5‐f]quinoxaline or N‐Nitrosodiethylamine

T. Tsukamoto, M. Tatematsu, S. Fukushima, 2002, Japanese journal of cancer research : Gann.

Lipid synthesis is promoted by hypoxic adipocyte-derived exosomes in 3T3-L1 cells.

H. Wanibuchi, M. Wei, H. Iwao, 2014, Biochemical and biophysical research communications.

Role of CYP2E1 in diethylnitrosamine-induced hepatocarcinogenesis in vivo.

S. Fukushima, H. Wanibuchi, K. Morimura, 2007, Cancer research.

Comparative Proteomics Analysis of Gastric Cancer Stem Cells

H. Wanibuchi, M. Yashiro, K. Hirakawa, 2014, PloS one.

Dammar resin, a non-mutagen, induces [corrected] oxidative stress and metabolic enzymes in the liver of gpt delta transgenic mouse which is different from a mutagen, 2-amino-3-methylimidazo[4,5-f]quinoline.

H. Wanibuchi, M. Wei, S. Yamano, 2012, Mutation research.

Lack of promoting effects of phenobarbital at low dose on diethylnitrosamine-induced hepatocarcinogenesis in TGF-alpha transgenic mice.

S. Fukushima, G. Merlino, R. Puatanachokchai, 2006, Asian Pacific journal of cancer prevention : APJCP.

Myristoylated alanine-rich C-kinase substrate as a prognostic biomarker in human primary lung squamous cell carcinoma.

H. Wanibuchi, M. Wei, S. Suehiro, 2013, Cancer biomarkers : section A of Disease markers.

Hypoxia-inducible factor-2 alpha up-regulates CD70 under hypoxia and enhances anchorage-independent growth and aggressiveness in cancer cells

H. Kato, L. Poellinger, H. Wanibuchi, 2018, Oncotarget.

Increased oxidative stress with gene alteration in urinary bladder urothelium after the Chernobyl accident

M. Kaneko, S. Fukushima, H. Wanibuchi, 2000, International journal of cancer.

Lack of Inhibitory Effects of an Anti-angiogenesis Drug, TNP-470, on Rat Urinary Bladder Papillomatosis Induced by Mechanical Stimulation

S. Fukushima, H. Wanibuchi, K. Morimura, 2002 .

Vascular endothelial growth factor mRNA levels as a biomarker for short‐term N‐butyl‐N‐(4‐hydroxybutyl) nitrosamine‐induced rat bladder carcinogenesis bioassay

S. Fukushima, H. Wanibuchi, S. Wakui, 2015, Journal of applied toxicology : JAT.

Chemopreventive effects of 13alpha,14alpha-epoxy-3beta-methoxyserratan-21beta-ol (PJJ-34), a serratane-type triterpenoid, in a rat multi-organ carcinogenesis bioassay.

S. Fukushima, H. Wanibuchi, M. Wei, 2010, Cancer letters.

Upregulation of fibroblast growth factor receptor 3 and epidermal growth factor receptors, in association with Raf‐1, in urothelial dysplasia and carcinoma in situ after the Chernobyl accident

S. Fukushima, H. Wanibuchi, K. Morimura, 2006, Cancer science.

Possible distinct molecular carcinogenic pathways for bladder cancer in Ukraine, before and after the Chernobyl disaster.

S. Fukushima, H. Wanibuchi, K. Morimura, 2004, Oncology reports.

Granular C3 Dermatosis.

T. Fujita, H. Wanibuchi, T. Nishino, 2016, Acta dermato-venereologica.

Inhibition of rat urinary bladder carcinogenesis by the antiangiogenic drug TNP-470.

S. Fukushima, H. Wanibuchi, K. Morimura, 2006, Asian Pacific journal of cancer prevention : APJCP.

Presence of a threshold for promoting effects of phenobarbital on diethylnitrosamine-induced hepatic foci in the rat.

H. Wanibuchi, S. Imaoka, Y. Funae, 1998, Carcinogenesis.

Ethanol-extracted propolis enhances BBN-initiated urinary bladder carcinogenesis via non-mutagenic mechanisms in rats.

H. Wanibuchi, Kenichiro Doi, S. Yamano, 2015, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Gene-modified embryonic stem cell test to characterize chemical risks

S. Fukushima, H. Wanibuchi, M. Hayashi, 2015, Environmental Science and Pollution Research.

Nephronectin Expression in Glomeruli of Renal Biopsy Specimens from Various Kidney Diseases: Nephronectin Is Expressed in the Mesangial Matrix Expansion of Diabetic Nephropathy

S. Fukumoto, H. Wanibuchi, M. Wei, 2013, Nephron Clinical Practice.

Role of Th-2 cytokines in the development of Barrett’s esophagus in rats

H. Wanibuchi, M. Wei, K. Tominaga, 2011, Journal of Gastroenterology.

White, but not Red, Ginseng Inhibits Progression of Intestinal Carcinogenesis in Rats.

M. Kaneko, S. Fukushima, H. Wanibuchi, 2002, Asian Pacific journal of cancer prevention : APJCP.

Alteration of Esophageal Microbiome by Antibiotic Treatment Does Not Affect Incidence of Rat Esophageal Adenocarcinoma

H. Wanibuchi, K. Tominaga, Toshio Watanabe, 2016, Digestive Diseases and Sciences.

Lack of Influence of Testicular Castration or Sialoadenectomy on Sodium L-Ascorbate Promotion of Urinary Bladder Carcinogenesis in Male F344 Rats

S. Fukushima, H. Wanibuchi, K. Morimura, 2003 .

Lack of modification of rat hepatocarcinogenesis by fernane-type triterpenoids, isolated from a Euphorbia genus.

S. Fukushima, H. Wanibuchi, K. Morimura, 2002, Teratogenesis, carcinogenesis, and mutagenesis.

FOXP3 and CXCR4-positive regulatory T cells in the tumor stroma as indicators of tumor immunity in the conjunctival squamous cell carcinoma microenvironment

H. Wanibuchi, A. Azumi, M. Tagami, 2022, PloS one.

Role of deltaNp63pos CD44vpos cells in the development of N‐nitroso‐tris‐chloroethylurea‐induced peripheral‐type mouse lung squamous cell carcinomas

H. Wanibuchi, S. Okada, Kenichiro Doi, 2016, Cancer science.

Determination of Hepatotoxicity and Its Underlying Metabolic Basis of 1,2-Dichloropropane in Male Syrian Hamsters and B6C3F1 Mice.

H. Wanibuchi, S. Yamano, M. Fujioka, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Potassium Bromate Enhances N-Ethyl-N-Hydroxyethylnitrosamine–Induced Kidney Carcinogenesis Only at High Doses in Wistar Rats: Indication of the Existence of an Enhancement Threshold

S. Fukushima, Masahiko Kushida, H. Wanibuchi, 2009, Toxicologic pathology.

Valerian Inhibits Rat Hepatocarcinogenesis by Activating GABA(A) Receptor-Mediated Signaling

S. Fukushima, H. Wanibuchi, K. Morimura, 2014, PloS one.

Significance of Cyclin D1 Overexpression in Transitional Cell Carcinomas of the Urinary Bladder and its Correlation with Histopathological Features

S. Fukushima, H. Wanibuchi, K. Morimura, 1997 .

Inhibition of Development of N, N′‐Dimethylhydrazine‐induced Rat Colonic Aberrant Crypt Foci by Pre, Post and Simultaneous Treatments with 24R,25‐Dihydroxyvitamin D3

S. Fukushima, H. Wanibuchi, K. Morimura, 1997, Japanese journal of cancer research : Gann.

Molecular cytogenetic identification of cyclin D1 gene amplification in a renal pelvic tumor attributed to phenacetin abuse

S. Fukushima, H. Wanibuchi, M. Hirose, 1999, Pathology international.

Lack of Hepatocarcinogenicity of Combinations of Low Doses of 2-amino-3, 8-dimethylimidazo[4,5- f ]quinoxaline and Diethylnitrosamine in Rats: Indication for the Existence of a Threshold for Genotoxic Carcinogens

S. Fukushima, H. Wanibuchi, M. Wei, 2012, Journal of toxicologic pathology.

Low‐dose carcinogenicity of 2‐amino‐3‐methylimidazo[4,5‐f ]quinoline in rats: Evidence for the existence of no‐effect levels and a mechanism involving p21Cip / WAF1

M. Tatematsu, S. Fukushima, H. Wanibuchi, 2011, Cancer science.

Thresholds for Genotoxic Carcinogens: Evidence from Mechanism‐Based Carcinogenicity Studies

S. Fukushima, H. Wanibuchi, M. Wei, 2010 .

Existence of a no effect level for MeIQx hepatocarcinogenicity on a background of thioacetamide‐induced liver damage in rats

S. Fukushima, H. Wanibuchi, K. Morimura, 2006, Cancer science.

Existence of No Hepatocarcinogenic Effect Levels of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline with or without Coadministration with Ethanol

S. Fukushima, H. Wanibuchi, K. Morimura, 2006, Toxicologic pathology.

Existence of no-observed effect levels for 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline on hepatic preneoplastic lesion development in BN rats.

S. Fukushima, R. Puatanachokchai, H. Wanibuchi, 2006, Cancer letters.

No-observed effect levels for carcinogenicity and for in vivo mutagenicity of a genotoxic carcinogen.

T. Ushijima, K. Takaoka, S. Fukushima, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Existence of a threshold for induction of aberrant crypt foci in the rat colon with low doses of 2-amino-1-methyl-6-phenolimidazo[4,5-b]pyridine.

T. Tsukamoto, M. Tatematsu, S. Fukushima, 2004, Toxicological sciences : an official journal of the Society of Toxicology.

Lack of initiation activity in rat liver of low doses of 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline.

T. Tsukamoto, M. Tatematsu, S. Fukushima, 2003, Cancer letters.

Establishment of a New Scirrhous Gastric Cancer Cell Line with FGFR2 Overexpression, OCUM-14

H. Wanibuchi, M. Yashiro, K. Hirakawa, 2019, Annals of Surgical Oncology.

Renal Pelvic Carcinoma Producing Granulocyte Colony-Stimulating Factor: Report of a Case

S. Fukushima, H. Wanibuchi, T. Yamane, 2001, Surgery Today.

Chemopreventive effects of a serratane-type triterpenoid, 3alpha-methoxyserrat-14-en-21beta-ol (PJ-1), against rat lung carcinogenesis.

S. Fukushima, H. Wanibuchi, R. Tanaka, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

L-Leucine and L-isoleucine enhance growth of BBN-induced urothelial tumors in the rat bladder by modulating expression of amino acid transporters and tumorigenesis-associated genes.

H. Wanibuchi, M. Wei, S. Yamano, 2013, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Quantitative analysis of mutagenicity and carcinogenicity of 2-amino-3-methylimidazo[4,5-f]quinoline in F344 gpt delta transgenic rats.

S. Fukushima, H. Wanibuchi, Y. Totsuka, 2019, Mutagenesis.

Lack of Urinary Bladder Carcinogenicity of Sodium L-Ascorbate in Human c-Ha-ras Proto-Oncogene Transgenic Rats

S. Fukushima, H. Wanibuchi, K. Morimura, 2005, Toxicologic pathology.

Complexin-2 (CPLX2) as a potential prognostic biomarker in human lung high grade neuroendocrine tumors.

H. Wanibuchi, M. Wei, N. Izumi, 2013, Cancer biomarkers : section A of Disease markers.

Development of Medium-Term Bioassays for Detection of Chemopreventive Agents

S. Fukushima, H. Wanibuchi, Satoru Takahashi, 1997 .

Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis.

S. Fukushima, H. Wanibuchi, K. Morimura, 2007, Oncology reports.

Paraneoplastic Ma Antigen–Like 1 as a Potential Prognostic Biomarker in Human Pancreatic Ductal Adenocarcinoma

K. Wakasa, H. Wanibuchi, M. Wei, 2015, Pancreas.

Inhibition by ginseng of colon carcinogenesis in rats.

Wei Li, S. Fukushima, H. Wanibuchi, 2001, Journal of Korean medical science.

Threshold in Carcinogenicity of Genotoxic Carcinogens

S. Fukushima, H. Wanibuchi, M. Wei, 2014 .

Possible Involvement of Adaptation Mechanisms in the Achievement of an Ineffective Dose Range for the Carcinogenicity of Genotoxic Carcinogens

S. Fukushima, H. Wanibuchi, Y. Konishi, 2008 .

Value of GST-P Positive Preneoplastic Hepatic Foci in Dose-Response Studies of Hepatocarcinogenesis: Evidence for Practical Thresholds with Both Genotoxic and Nongenotoxic Carcinogens. A Review of Recent Work

Hiroyuki Tsuda, Malcolm A Moore, Masae Tatematsu, 2003, Toxicologic pathology.

An autopsy report of graft-versus-host disease (GVHD) following blood transfusion.

S. Fukushima, H. Wanibuchi, C. Masuda, 1999, Osaka city medical journal.

Accelerated glomerulosclerosis in alloxan-induced diabetic rabbits with anti-glomerular basement membrane nephritis.

H. Wanibuchi, M. Ueda, T. Fujimoto, 1991, Tohoku journal of experimental medicine.

Granular C 3 Dermatosis

T. Fujita, H. Wanibuchi, T. Nishino, 2016 .

[Sibling cases of nephritis resembling membranoproliferative glomerulonephritis].

S. Fukumoto, H. Wanibuchi, M. Emoto, 2002, Nihon Jinzo Gakkai shi.

Lack of potential of low dose N-nitrosodimethylamine to induce preneoplastic lesions, glutathione S-transferase placental form-positive foci, in rat liver.

T. Tsukamoto, M. Tatematsu, S. Fukushima, 2005, Cancer letters.

Role of oxidative DNA damage caused by carbon tetrachloride-induced liver injury -- enhancement of MeIQ-induced glutathione S-transferase placental form-positive foci in rats.

S. Seki, S. Fukushima, H. Wanibuchi, 2002, Cancer letters.

Differences in susceptibility to N‐butyl‐N‐(4‐hydroxybutyl)nitrosamine‐induced urinary bladder carcinogenesis between SD/gShi rats with spontaneous hypospermatogenesis and SD/cShi rats with spontaneous hydronephrosis

S. Fukushima, H. Wanibuchi, K. Tatematsu, 2005, Cancer science.

Detailed low‐dose study of 1,1‐b™IS(p‐chlorophenyl)‐2,2,2‐ trichloroethane carcinogenesis suggests the possibility of a hormetic effect

S. Fukushima, H. Wanibuchi, T. Nishikawa, 2002, International journal of cancer.

Hormonally active doses of isoflavone aglycones promote mammary and endometrial carcinogenesis and alter the molecular tumor environment in Donryu rats.

S. Fukushima, H. Wanibuchi, M. Wei, 2012, Toxicological sciences : an official journal of the Society of Toxicology.

Promoting Effect of Sodium L-Ascorbate on N-Butyl-N-(4-hydroxybutyl)nitrosamine-induced Renal Pelvic Carcinogenesis in SD/cShi Rats of Both Sexes

S. Fukushima, H. Wanibuchi, T. Maruyama, 2003 .

Significance of overexpression of metallothionein in mouse urinary bladder focal lesions induced by treatment with N‐butyl‐N‐(4‐hydroxybutyl)‐nitrosamine

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Cancer science.

Tumor-associated MUC 5 AC stimulates in vivo tumorigenicity of human pancreatic cancer

H. Wanibuchi, T. Sawada, K. Hirakawa, 2022 .

Surf4 modulates STIM1-dependent calcium entry.

T. Kinashi, Y. Ohkawa, H. Wanibuchi, 2012, Biochemical and biophysical research communications.

Carcinogenic Potential of 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) in Severe Combined Immunodeficient (SCID) Mice

K. Takaoka, S. Fukushima, H. Wanibuchi, 2004 .

Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats

H. Wanibuchi, Shugo Suzuki, M. Suda, 2019, Archives of Toxicology.

Testicular toxicity of DEHP, but not DEHA, is elevated under conditions of thioacetamide-induced liver damage.

S. Fukushima, H. Wanibuchi, K. Morimura, 2006, Reproductive toxicology.

A case report of inflammatory pseudotumor of the urinary bladder.

S. Fukushima, H. Wanibuchi, Y. Yamada, 1995, Osaka city medical journal.

Genotoxicity and subacute toxicity studies of a new astaxanthin-containing Phaffia rhodozyma extract.

Masanori Kato, H. Wanibuchi, M. Wei, 2014, The Journal of toxicological sciences.

Role of γ-H2AX as a biomarker for detection of bladder carcinogens in F344 rats

H. Wanibuchi, A. Naiki‐Ito, Satoru Takahashi, 2020, Journal of toxicologic pathology.

Comprehensive analysis of DNA adducts (DNA adductome analysis) in the liver of rats treated with 1,4-dioxane

S. Fukushima, H. Wanibuchi, H. Nakagama, 2020, Proceedings of the Japan Academy. Series B, Physical and biological sciences.

Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport

A. Miyazawa, H. Wanibuchi, T. Nagai, 2017, Scientific Reports.

Prognostic value of the frequency of vascular invasion in stage I non-small cell lung cancer

H. Wanibuchi, S. Okada, N. Izumi, 2016, General Thoracic and Cardiovascular Surgery.

Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis.

H. Wanibuchi, M. Wei, M. Inaba, 2012, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Ndel1 suppresses ciliogenesis in proliferating cells by regulating the trichoplein–Aurora A pathway

M. Inagaki, H. Wanibuchi, H. Goto, 2016, The Journal of cell biology.

Proteome Characteristics of Non-Alcoholic Steatohepatitis Liver Tissue and Associated Hepatocellular Carcinomas

H. Wanibuchi, N. Kawada, H. Fujii, 2017, International journal of molecular sciences.

DDX39 acts as a suppressor of invasion for bladder cancer

H. Wanibuchi, M. Wei, T. Nakatani, 2012, Cancer science.

o-Toluidine metabolism and effects in the urinary bladder of humanized-liver mice.

H. Suemizu, H. Wanibuchi, Shugo Suzuki, 2023, Toxicology.

Evidence of a Threshold-Effect for 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline Liver Carcinogenicity in F344/DuCrj Rats

S. Fukushima, H. Wanibuchi, K. Morimura, 2008, Toxicologic pathology.

Aberrant expression of E‐cadherin and β‐catenin in association with transforming growth factor‐β1 in urinary bladder lesions in humans after the Chernobyl accident

S. Fukushima, H. Wanibuchi, K. Morimura, 2006, Cancer science.

Presence of a no-observed effect level for enhancing effects of development of the α-isomer of benzene hexachloride (α-BHC) on diethylnitrosamine-initiated hepatic foci in rats

S. Fukushima, H. Wanibuchi, M. Wei, 2001 .

Lack of carcinogenicity of enzymatically modified isoquercitrin in F344/DuCrj rats.

M. Kaneko, S. Fukushima, H. Wanibuchi, 2004, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Anti‐PD‐L1 treatment enhances antitumor effect of everolimus in a mouse model of renal cell carcinoma

H. Wanibuchi, T. Nakatani, S. Yamano, 2016, Cancer science.

Lack of Inhibition of BBN-induced Bladder Carcinogenesis in C57BL/6 Mice by Intravesical Instillation of KRN 7000

S. Fukushima, H. Wanibuchi, K. Morimura, 2003 .

Low dose DDT inhibition of hepatocarcinogenesis initiated by diethylnitrosamine in male rats: possible mechanisms.

S. Fukushima, Masahiko Kushida, H. Wanibuchi, 2005, Toxicology and applied pharmacology.

Post-natal treatment by a blood-brain-barrier permeable calpain inhibitor, SNJ1945 rescued defective function in lissencephaly

Makoto Sato, T. Miyakawa, A. Wynshaw-Boris, 2013, Scientific Reports.

Acetoaceto-o-Toluidide Enhances Cellular Proliferative Activity in the Urinary Bladder of Rats.

H. Wanibuchi, A. Takeuchi, M. Fujioka, 2019, Toxicological sciences : an official journal of the Society of Toxicology.

Carbonic anhydrase 2 is a novel invasion‐associated factor in urinary bladder cancers

H. Wanibuchi, T. Nakatani, S. Yamano, 2017, Cancer science.

Roles of Leucine and Isoleucine in Experimental Models of Bladder Carcinogenesis

H. Wanibuchi, M. Gi, 2015 .

Isoleucine, Leucine and Their Role in Experimental Models of Bladder Carcinogenesis

H. Wanibuchi, M. Wei, S. Yamano, 2015 .

Evaluation of the Subchronic Toxicity of Dietary Administered Equisetum arvense in F344 Rats

H. Wanibuchi, M. Wei, Naomi Ishii, 2010, Journal of toxicologic pathology.

Chemopreventive effect of 24R,25-dihydroxyvitamin D(3) in N, N'-dimethylhydrazine-induced rat colon carcinogenesis.

S. Fukushima, H. Wanibuchi, E. Salim, 2000, Carcinogenesis.

Enhancement of preneoplastic lesion yield by Chios Mastic Gum in a rat liver medium-term carcinogenesis bioassay.

H. Wanibuchi, M. Wei, Masayo Inoue, 2009, Toxicology and applied pharmacology.

Are there thresholds for carcinogens carcinogenicity

S. Fukushima, H. Wanibuchi, M. Wei, 2008 .

Phenobarbital at low dose exerts hormesis in rat hepatocarcinogenesis by reducing oxidative DNA damage, altering cell proliferation, apoptosis and gene expression.

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Carcinogenesis.

N-acetylcysteine and S-methylcysteine inhibit MeIQx rat hepatocarcinogenesis in the post-initiation stage.

S. Hayashi, S. Fukushima, H. Wanibuchi, 2006, Carcinogenesis.

Squamous Cell Carcinoma Forestomach, Rat

S. Fukushima, H. Wanibuchi, M. Hirose, 1997 .

Irradiation plus myeloid-derived suppressor cell-targeted therapy for overcoming treatment resistance in immunologically cold urothelial carcinoma

H. Wanibuchi, J. Uchida, Minoru Kato, 2023, British Journal of Cancer.

Assessment of cell cycle-related elements p53, p21WAF1/Cip1, cyclin D1 and PCNA in a mixed transitional cell carcinoma and adenocarcinoma of the renal pelvis: a case report.

S. Fukushima, H. Wanibuchi, C. Masuda, 1998, Japanese journal of clinical oncology.

Current and emerging challenges in toxicopathology: carcinogenic threshold of phenobarbital and proof of arsenic carcinogenicity using rat medium-term bioassays for carcinogens.

S. Fukushima, H. Wanibuchi, K. Morimura, 2005, Toxicology and applied pharmacology.

Lack of inhibitory effects of the Ju-myo protein on development of glutathione S-transferase placental form-positive foci in the male F344 rat liver.

S. Fukushima, H. Wanibuchi, Y. Yano, 1999, The Journal of toxicological sciences.

Susceptibility of Four F1 Hybrids of Male Rats to the Promoting Effects of Sodium L-ascorbate in Two-Stage Urinary Bladder Carcinogenesis

S. Fukushima, R. Puatanachokchai, H. Wanibuchi, 2006 .

Absence of β-catenin Mutations in Mouse Hepatoblastomas Induced by N, N-dimethylformamide

S. Fukushima, H. Wanibuchi, K. Morimura, 2004 .

Existence of a Threshold for the Genotoxic Carcinogens: Evidence from Mechanism-based Carcinogenicity Studies

S. Fukushima, H. Wanibuchi, M. Wei, 2009 .

Ethanol-Extracted Brazilian Propolis Exerts Protective Effects on Tumorigenesis in Wistar Hannover Rats

H. Wanibuchi, Kenichiro Doi, M. Fujioka, 2016, PloS one.

Hsc70 Contributes to Cancer Cell Survival by Preventing Rab1A Degradation under Stress Conditions

Y. Ohkawa, H. Wanibuchi, K. Miura, 2014, PloS one.

Long-term survival after resection for small cell carcinoma of the esophagus.

H. Maeta, S. Yachida, H. Usuki, 2001, The Annals of thoracic surgery.

Toxicity vs. beneficial effects of phytoestrogens

S. Fukushima, H. Wanibuchi, K. Morimura, 2003 .

Epithelial cell proliferation in the digestive tract induced by space restriction and water-immersion stress.

S. Fukushima, H. Wanibuchi, A. Nishikawa, 1998, Cancer letters.

Deficiency of CHAMP1, a gene related to intellectual disability, causes impaired neuronal development and a mild behavioural phenotype

T. Abe, K. Kinoshita, T. Miyakawa, 2022, Brain communications.

Preventive Effects of Spirogyra neglecta and a Polysaccharide Extract against Dextran Sodium Sulfate Induced Colitis in Mice.

H. Wanibuchi, R. Wongpoomchai, Naomi Ishii, 2016, Asian Pacific journal of cancer prevention : APJCP.

Rat monoclonal antibody specific for septin 9.

H. Wanibuchi, M. Azuma, E. Okazaki, 2010, Hybridoma.

Chronic dietary toxicity and carcinogenicity studies of dammar resin in F344 rats

H. Wanibuchi, S. Hayashi, S. Yamano, 2018, Archives of Toxicology.

JTE‐522, a selective cyclooxygenase‐2 inhibitor, inhibits induction but not growth and invasion of 1,2‐dimethylhydrazine‐induced tubular adenocarcinomas of colon in rats

S. Fukushima, H. Wanibuchi, K. Morimura, 2005, International journal of cancer.

Chemopreventive effect of JTE-522, a selective cyclooxygenase-2 inhibitor, on 1, 2-dimethylhydrazine-induced rat colon carcinogenesis.

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Cancer letters.

Qualitative and quantitative approaches in the dose-response assessment of genotoxic carcinogens.

S. Fukushima, H. Wanibuchi, M. Matsumoto, 2016, Mutagenesis.

Absence of β-Catenin Alteration in Hepatic Tumors Induced by p-Nitroanisole in Crj:BDF1 Mice

S. Fukushima, Masahiko Kushida, H. Wanibuchi, 2006, Toxicologic pathology.

Recent Insights into the Biomarkers, Molecular Targets and Mechanisms of Non-Alcoholic Steatohepatitis-Driven Hepatocarcinogenesis

H. Wanibuchi, A. Kakehashi, Shugo Suzuki, 2023, Cancers.

Establishment of a 5-fluorouracil-resistant triple-negative breast cancer cell line.

H. Wanibuchi, K. Miura, H. Iwao, 2013, International journal of oncology.

Weak enhancing effects of simultaneous ethanol administration on chemically induced rat esophageal tumorigenesis.

M. Kaneko, H. Wanibuchi, K. Morimura, 2002, Oncology reports.

Urinary bladder carcinogenesis induced by chronic exposure to persistent low-dose ionizing radiation after Chernobyl accident.

S. Fukushima, H. Wanibuchi, K. Morimura, 2009, Carcinogenesis.

Elevated oxidative stress and DNA damage and repair levels in urinary bladder carcinomas associated with schistosomiasis

S. Fukushima, H. Wanibuchi, K. Morimura, 2008, International Journal of Cancer.

No inhibition of urinary bladder carcinogenesis in rats with intravesical instillation of alpha-galactosylceramide.

S. Fukushima, H. Wanibuchi, K. Morimura, 2003, Asian Pacific journal of cancer prevention : APJCP.

ER membrane protein complex 1 interacts with STIM1 and regulates store-operated Ca2+ entry.

H. Wanibuchi, Y. Baba, M. Shiota, 2021, Journal of biochemistry.

Potassium Bromate Enhances N-Ethyl-N-Hydroxyethylnitrosamine–Induced Kidney Carcinogenesis Only at High Doses in Wistar Rats: Indication of the Existence of an Enhancement Threshold

S. Fukushima, Masahiko Kushida, H. Wanibuchi, 2009, Toxicologic pathology (Print).

Concentration dependent promoting effects of sodium L-ascorbate with the same total dose in a rat two-stage urinary bladder carcinogenesis.

S. Fukushima, H. Wanibuchi, K. Morimura, 1999, Cancer letters.