J. Geiger

发表

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion

M. Stack, P. Friedl, Katarina Wolf, 2007, Nature Cell Biology.

Monitoring of clopidogrel action: comparison of methods.

J. Geiger, R. Schinzel, Lino Teichmann, 2005, Clinical chemistry.

A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation.

J. Timmer, T. Dandekar, J. Geiger, 2013, Molecular bioSystems.

Temporal quantitative phosphoproteomics of ADP stimulation reveals novel central nodes in platelet activation and inhibition.

Albert Sickmann, Christian Fufezan, Stepan Gambaryan, 2017, Blood.

A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways.

J. Geiger, R. Schinzel, U. Walter, 2010, Analytical biochemistry.

Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay

J. Geiger, S. Gambaryan, C. Schütz, 2013, Transfusion Medicine and Hemotherapy.

Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways.

Lennart Martens, Oliver Kohlbacher, Marc Vaudel, 2014, Blood.

Deciphering of ADP‐induced, phosphotyrosine‐dependent signaling networks in human platelets by Src‐homology 2 region (SH2)‐profiling

U. Walter, J. Geiger, A. Sickmann, 2013, Proteomics.

Defective nitrovasodilator-stimulated protein phosphorylation and calcium regulation in cGMP-dependent protein kinase-deficient human platelets of chronic myelocytic leukemia.

U. Walter, J. Geiger, H. Ullrich, 1993, The Journal of biological chemistry.

Anti-aggregatory drugs: I. Platelet receptor antagonists

J. Geiger, 1999 .

Inhibition of platelet function by cyclic nucleotides and cyclic nucleotide-dependent protein kinases

U. Walter, J. Geiger, C. Nolte, 1991 .

Thrombin stimulation of p38 MAP kinase in human platelets is mediated by ADP and thromboxane A2 and inhibited by cGMP/cGMP-dependent protein kinase.

U. Walter, J. Geiger, S. Gambaryan, 2007, Blood.

Thrombin stimulation of p 38 MAP kinase in human platelets is mediated by ADP and thromboxane A 2 and inhibited by cGMP / cGMP-dependent protein kinase

U. Walter, J. Geiger, S. Gambaryan, 2006 .

Platelet regulation by NO/cGMP signaling and NAD(P)H oxidase-generated ROS.

U. Walter, J. Geiger, S. Gambaryan, 2006, Blood cells, molecules & diseases.

Flow Cytometry Analysis of Intracellular VASP Phosphorylation for the Assessment of Activating and Inhibitory Signal Transduction Pathways in Human Platelets

U. Walter, J. Geiger, M. Eigenthaler, 1999, Thrombosis and Haemostasis.

Response: platelet transcriptome and proteome--relation rather than correlation.

U. Walter, J. Geiger, R. Zahedi, 2013, Blood.

Phosphatidylserine surface expression and integrin αIIbβ3 activity on thrombin/convulxin stimulated platelets/particles of different sizes

U. Walter, J. Geiger, S. Gambaryan, 2009, British journal of haematology.

Platelet NAD(P)H-oxidase-generated ROS production regulates alphaIIbbeta3-integrin activation independent of the NO/cGMP pathway.

U. Walter, J. Geiger, B. Nieswandt, 2005, Blood.

Platelet NAD(P)H-oxidase–generated ROS production regulates IIb 3-integrin activation independent of the NO/cGMP pathway

U. Walter, J. Geiger, B. Nieswandt, 2005 .

: advise in design and interpretation of platelet ROS experiments

U. Walter, J. Geiger, B. Nieswandt, 2005 .

Inhibition of platelet P2Y12 and alpha2A receptor signaling by cGMP-dependent protein kinase.

U. Walter, J. Geiger, P. Hönig-Liedl, 2002, Biochemical pharmacology.

The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways.

Lennart Martens, Marc Vaudel, Albert Sickmann, 2012, Blood.

Ligand specificity and ticlopidine effects distinguish three human platelet ADP receptors.

U. Walter, J. Geiger, P. Schanzenbächer, 1998, European journal of pharmacology.

Regulation of calcium mobilization and entry in human platelets by endothelium-derived factors.

U. Walter, J. Geiger, C. Nolte, 1994, The American journal of physiology.

Role of cyclic nucleotide-dependent protein kinases and their common substrate VASP in the regulation of human platelets.

U. Walter, J. Geiger, M. Reinhard, 1993, Advances in experimental medicine and biology.

Specific impairment of human platelet P2Y(AC) ADP receptor-mediated signaling by the antiplatelet drug clopidogrel.

U. Walter, J. Geiger, J. Herbert, 1999, Arteriosclerosis, thrombosis, and vascular biology.

Quantification of cAMP and cGMP analogs in intact cells: pitfalls in enzyme immunoassays for cyclic nucleotides

J. Geiger, H. Genieser, F. Schwede, 2011, Naunyn-Schmiedeberg's Archives of Pharmacology.

The cGMP-dependent protein kinase-gene, protein, and function

U. Walter, S. Lohmann, J. Geiger, 2004, Neurochemical Research.

Time-resolved in silico modeling of fine-tuned cAMP signaling in platelets: feedback loops, titrated phosphorylations and pharmacological modulation

Thomas Dandekar, Marcus T. Dittrich, Jörg Geiger, 2011, BMC Systems Biology.

Megakaryocyte hyperplasia and enhanced agonist-induced platelet activation in vasodilator-stimulated phosphoprotein knockout mice.

K. Knobeloch, U. Walter, J. Geiger, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Inhibitors of platelet signal transduction as anti-aggregatory drugs

J. Geiger, 2001, Expert opinion on investigational drugs.

Role of cGMP and cGMP-dependent protein kinase in nitrovasodilator inhibition of agonist-evoked calcium elevation in human platelets.

U. Walter, J. Geiger, S. Sage, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Properties and regulation of human platelet cation channels.

U. Walter, J. Geiger, 1993, EXS.

Potent inhibition of human platelets by cGMP analogs independent of cGMP-dependent protein kinase.

U. Walter, J. Geiger, S. Gambaryan, 2004, Blood.

Human cyclic GMP-dependent protein kinase I beta overexpression increases phosphorylation of an endogenous focal contact-associated vasodilator-stimulated phosphoprotein without altering the thrombin-evoked calcium response.

U. Walter, S. Lohmann, J. Geiger, 1994, Molecular pharmacology.

Identification of organic dyes by direct analysis in real time-time of flight mass spectrometry

J. Geiger, C. Deroo, R. Armitage, 2012 .

Platelet-vessel wall interactions, focal adhesions, and the mechanism of action of endothelial factors.

U. Walter, J. Geiger, R. Silber, 1995, Agents and actions. Supplements.

Dynamical modelling of prostaglandin signalling in platelets reveals individual receptor contributions and feedback properties.

J. Timmer, T. Dandekar, J. Geiger, 2013, Molecular bioSystems.

Quantification of cAMP and cGMP analogs in intact cells: pitfals in enzyme immunoassays for cyclic nucleotides

J. Geiger, H. Genieser, F. Schwede, 2011, BMC Pharmacology.

A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling.

Jens Timmer, Thomas Dandekar, Hariharan Subramanian, 2014, Molecular bioSystems.

The good, the bad, the ugly: Validating the mass spectrometric analysis of modified peptides

Albert Sickmann, René Peiman Zahedi, Jörg Geiger, 2011, Proteomics.

Deciphering of ADP‐induced, phosphotyrosine‐dependent signaling networks in human platelets by Src‐homology 2 region (SH2)‐profiling

U. Walter, J. Geiger, A. Sickmann, 2013, Proteomics.

A protein phosphorylation-based assay for screening and monitoring of drugs modulating cyclic nucleotide pathways.

J. Geiger, R. Schinzel, U. Walter, 2010, Analytical biochemistry.