Yongneng Zhang

发表

High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1

Bo-zhi Cai, Jiexiong Huang, Jidong Cheng, 2016, Cellular Physiology and Biochemistry.

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

Youfeng Li, Xiaojun Tan, Jiexiong Huang, 2014, PloS one.

A Phase-2 NIH-sponsored Randomized Clinical Trial of Rituximab in Scleroderma-associated Pulmonary Arterial Hypertension Did Not Reach Significance for Its Endpoints: End of Story? Not So Fast!

Yongneng Zhang, E. Michelakis, 2021, American journal of respiratory and critical care medicine.

SNPs for Genes Encoding the Mitochondrial Proteins Sirtuin3 and Uncoupling Protein 2 Are Associated With Disease Severity, Type 2 Diabetes, and Outcomes in Patients With Pulmonary Arterial Hypertension and This Is Recapitulated in a New Mouse Model Lacking Both Genes

Yongneng Zhang, Aristeidis E. Boukouris, Sotirios D. Zervopoulos, 2021, Journal of the American Heart Association.

TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure

J. Dyck, Yongneng Zhang, K. Gopal, 2022, Science Translational Medicine.

A reversible metabolic stress-sensitive regulation of CRMP2A orchestrates EMT/stemness and increases metastatic potential in cancer.

Yongneng Zhang, Aristeidis E. Boukouris, Sotirios D. Zervopoulos, 2022, Cell reports.

FoxO1 inhibition alleviates type 2 diabetes-related diastolic dysfunction by increasing myocardial pyruvate dehydrogenase activity.

Yongneng Zhang, K. Gopal, F. Eaton, 2021, Cell reports.

Metformin inhibits estrogen‐dependent endometrial cancer cell growth by activating the AMPK–FOXO1 signal pathway

Bo-zhi Cai, Jiexiong Huang, Jidong Cheng, 2016, Cancer science.

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

Bo-zhi Cai, Youfeng Li, Jidong Cheng, 2013, Molecular and Cellular Endocrinology.

High uric acid directly inhibits insulin signalling and induces insulin resistance.

Jidong Cheng, Chaohuan Luo, Zhi Li, 2014, Biochemical and biophysical research communications.

p53‐Mediated Repression of the PGC1A (PPARG Coactivator 1α) and APLNR (Apelin Receptor) Signaling Pathways Limits Fatty Acid Oxidation Energetics: Implications for Cardio‐oncology

Yongneng Zhang, G. Lopaschuk, Aristeidis E. Boukouris, 2020, Journal of the American Heart Association.

Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity

Yongneng Zhang, K. Gopal, Aristeidis E. Boukouris, 2019, Science Translational Medicine.

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.

Robert C. Jones, S. Quake, K. Kaestner, 2022, Cell metabolism.

Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells

Jidong Cheng, Chaohuan Luo, Liangli Hong, 2017, Molecular and Cellular Endocrinology.

Changing cell fate in the wall of pulmonary arteries

Yongneng Zhang, E. Michelakis, 2022, Science Translational Medicine.