Tetsuya Yamamoto

发表

High Uric Acid Activates the ROS-AMPK Pathway, Impairs CD68 Expression and Inhibits OxLDL-Induced Foam-Cell Formation in a Human Monocytic Cell Line, THP-1

Bo-zhi Cai, Jiexiong Huang, Jidong Cheng, 2016, Cellular Physiology and Biochemistry.

AMP-Activated Protein Kinase Suppresses the In Vitro and In Vivo Proliferation of Hepatocellular Carcinoma

Youfeng Li, Xiaojun Tan, Jiexiong Huang, 2014, PloS one.

Sleep, cardiac autonomic function, and carotid atherosclerosis in patients with cardiovascular risks: HSCAA study.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2015, Atherosclerosis.

An Allopurinol-Controlled, Randomized, Double-Dummy, Double-Blind, Parallel Between-Group, Comparative Study of Febuxostat (TMX-67), a Non-Purine-Selective Inhibitor of Xanthine Oxidase, in Patients With Hyperuricemia Including Those With Gout in Japan: Phase 3 Clinical Study

H. Yamanaka, Toshitaka Nakamura, Tetsuya Yamamoto, 2011, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

Retroperitoneal ancient schwannoma presenting as an adrenal incidentaloma: CT and MR findings.

S. Hirota, Y. Moriwaki, Tetsuya Yamamoto, 2006, Magnetic resonance imaging.

Plasma levels of uridine correlate with blood pressure and indicators of myogenic purine degradation and insulin resistance in hypertensive patients.

I. Hisatome, Tetsuya Yamamoto, S. Sugihara, 2007, Circulation journal : official journal of the Japanese Circulation Society.

Partial HPRT Deficiency with a Novel Mutation of the HPRT Gene in Combination with Four Previously Reported Variants Associated with Hyperuricemia.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2015, Internal medicine.

Effect of inosine on the plasma concentration of uridine and purine bases.

Y. Moriwaki, Jidong Cheng, Tetsuya Yamamoto, 2002, Metabolism: clinical and experimental.

Febuxostat Therapy for Patients With Stage 3 CKD and Asymptomatic Hyperuricemia: A Randomized Trial.

S. Ito, Y. Ohashi, Tetsuya Yamamoto, 2018, American journal of kidney diseases : the official journal of the National Kidney Foundation.

Japanese Society of Gout and Uric & Nucleic Acids 2019 Guidelines for Management of Hyperuricemia and Gout 3rd edition

Y. Moriwaki, A. Taniguchi, I. Hisatome, 2020 .

Pharmacokinetic and Pharmacodynamic Analyses of Drug-Drug Interactions between Iguratimod and Warfarin.

Tetsuya Yamamoto, Keiichi Tanaka, M. Onoda, 2016, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

AGE/RAGE as a Mediator of Insulin Resistance or Metabolic Syndrome: Another Aspect of Metabolic Memory?

Tetsuya Yamamoto, H. Koyama, 2012 .

Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors – Hyogo Sleep Cardio-Autonomic Atherosclerosis study

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2017 .

A simple method of selecting gout patients for treatment with uricosuric agents, using spot urine and blood samples.

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 2002, The Journal of rheumatology.

Effects of febuxostat on serum urate level in Japanese hyperuricemia patients

Y. Moriwaki, A. Taniguchi, H. Yamanaka, 2015, Modern rheumatology.

Serum Urate Level is Independentlyassociated with Ca Level : Health Examination Findings

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2014 .

Expression of cyclooxygenase 2 and cytosolic phospholipase A2 in the liver tissue of patients with chronic hepatitis and liver cirrhosis

Jidong Cheng, Tetsuya Yamamoto, H. Imanishi, 2002 .

Receptor for Advanced Glycation End Products Regulates Adipocyte Hypertrophy and Insulin Sensitivity in Mice

S. Fukumoto, Tetsuya Yamamoto, Hiroshi Yamamoto, 2013, Diabetes.

Relationship Between Plasma Uridine and Insulin Resistance in Patients with Non-Insulin-Dependent Diabetes Mellitus

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2010, Nucleosides, nucleotides & nucleic acids.

Immunohistochemical localization of aldehyde and xanthine oxidase in rat tissues using polyclonal antibodies

Y. Moriwaki, Tetsuya Yamamoto, K. Higashino, 2005, Histochemistry and Cell Biology.

Increased Frequency of Metabolic Syndrome and Its Individual Metabolic Abnormalities in Japanese Patients With Primary Gout

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2010, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

Nonpharmacological Management of Gout and Hyperuricemia: Hints for Better Lifestyle

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2017, American journal of lifestyle medicine.

26 – Purines in Beer

Y. Moriwaki, Tetsuya Yamamoto, 2009 .

Effects of sucrose on plasma concentrations and urinary excretion of purine bases.

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2007, Metabolism: clinical and experimental.

Effect of ethanol on metabolism of purine bases (hypoxanthine, xanthine, and uric acid).

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2005, Clinica chimica acta; international journal of clinical chemistry.

lipoprotein in patients with primary gout . Increased concentrations of serum Lp ( a )

Y. Moriwaki, Tetsuya Yamamoto, K. Higashino, 2004 .

Effects of exercise and grape juice ingestion in combination on plasma concentrations of purine bases and uridine.

Y. Moriwaki, Tetsuya Yamamoto, S. Nishiguchi, 2008, Clinica chimica acta; international journal of clinical chemistry.

Effect of exercise and beer on the plasma concentration and urinary excretion of purine bases.

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 2003, The Journal of rheumatology.

Relationship Between Exercise and Beer Ingestion in Regard to Metabolism

Tetsuya Yamamoto, 2009 .

Biochemistry of uridine in plasma.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2011, Clinica chimica acta; international journal of clinical chemistry.

Allopurinol improves cardiac dysfunction after ischemia-reperfusion via reduction of oxidative stress in isolated perfused rat hearts.

I. Hisatome, Tetsuya Yamamoto, Y. Kinugasa, 2003, Circulation journal : official journal of the Japanese Circulation Society.

Xanthine oxidoreductase activity is correlated with insulin resistance and subclinical inflammation in young humans.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2017, Metabolism: clinical and experimental.

Silencing TXNIP ameliorates high uric acid-induced insulin resistance via the IRS2/AKT and Nrf2/HO-1 pathways in macrophages

Jidong Cheng, Wanling Zhuang, Tetsuya Yamamoto, 2022, Free Radical Biology and Medicine.

RETRACTED: Effects of ethanol on monosodium urate crystal-induced inflammation.

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2008, Cytokine.

Plasma interleukin (IL)-18 (interferon-gamma-inducing factor) and other inflammatory cytokines in patients with gouty arthritis and monosodium urate monohydrate crystal-induced secretion of IL-18.

Y. Moriwaki, Tetsuya Yamamoto, H. Tsutsui, 2006, Cytokine.

Multicenter, Open-Label Study of Long-Term Administration of Febuxostat (TMX-67) in Japanese Patients With Hyperuricemia Including Gout

H. Yamanaka, Toshitaka Nakamura, Tetsuya Yamamoto, 2011, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

Placebo-controlled double-blind dose-response study of the non-purine-selective xanthine oxidase inhibitor febuxostat (TMX-67) in patients with hyperuricemia (including gout patients) in japan: late phase 2 clinical study.

H. Yamanaka, Toshitaka Nakamura, Tetsuya Yamamoto, 2011, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

An allopurinol-controlled, multicenter, randomized, open-label, parallel between-group, comparative study of febuxostat (TMX-67), a non-purine-selective inhibitor of xanthine oxidase, in patients with hyperuricemia including those with gout in Japan: phase 2 exploratory clinical study.

H. Yamanaka, Toshitaka Nakamura, Tetsuya Yamamoto, 2011, Journal of clinical rheumatology.

Novel inhibitory effects of dotinurad, a selective urate reabsorption inhibitor, on urate crystal-induced activation of NLRP3 inflammasomes in macrophages

I. Hisatome, Tetsuya Yamamoto, S. Sugihara, 2020 .

Contribution of TIR domain-containing adapter inducing IFN-beta-mediated IL-18 release to LPS-induced liver injury in mice.

S. Akira, J. Tschopp, Tetsuya Yamamoto, 2009, Journal of hepatology.

Effect of interferon-γ on purine catabolic and salvage enzyme activities in rats

Y. Moriwaki, Tetsuya Yamamoto, K. Higashino, 1999 .

Effect of beer on the plasma concentrations of uridine and purine bases.

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 2002, Metabolism: clinical and experimental.

Effect of TNF-α inhibition on urinary albumin excretion in experimental diabetic rats

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2007, Acta Diabetologica.

Effect of TNF-alpha inhibition on urinary albumin excretion in experimental diabetic rats.

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2007, Acta diabetologica.

Elevated levels of interleukin-18 and tumor necrosis factor-alpha in serum of patients with type 2 diabetes mellitus: relationship with diabetic nephropathy.

Masafumi Koga, Y. Moriwaki, H. Okamura, 2003, Metabolism: clinical and experimental.

Uric acid inhibits HMGB1-TLR4-NF-κB signaling to alleviate oxygen-glucose deprivation/reoxygenation injury of microglia.

Jidong Cheng, I. Hisatome, Tetsuya Yamamoto, 2021, Biochemical and biophysical research communications.

Parameters for nutritional assessment in oral disease patients who received a elemental diet Elental® after the surgeries

Tetsuya Yamamoto, I. Kato, Jyusui Hirota, 1989 .

Effects of Oligonol®, an oligomerized polyphenol formulated from lychee fruit, on serum concentration and urinary excretion of uric acid

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2011 .

Effects of angiotensin II infusion on renal excretion of purine bases and oxypurinol.

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 2002, Metabolism: clinical and experimental.

Coexistent B-cell lymphoma and cutaneous T-cell lymphoma.

S. Hirota, Y. Moriwaki, Tetsuya Yamamoto, 2006, Internal medicine.

Expression of cyclooxygenase 2 and cytosolic phospholipase A(2) in the liver tissue of patients with chronic hepatitis and liver cirrhosis.

Jidong Cheng, Tetsuya Yamamoto, H. Imanishi, 2002, Hepatology research : the official journal of the Japan Society of Hepatology.

21-hydroxylase deficiency associated with male infertility: report of 2 cases with gene analyses.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2011, Internal medicine.

21-Hydroxylase Deficiency Presenting as an Adrenal Incidentaloma: Endocrinological Evaluation and Mutational Analysis

S. Hirota, Y. Moriwaki, Tetsuya Yamamoto, 2008 .

Effect of the angiotensin II receptor antagonist losartan on uric acid and oxypurine metabolism in healthy subjects.

I. Hisatome, Tetsuya Yamamoto, Y. Kinugasa, 2002, Internal medicine.

Immunohistochemical Demonstration of Adenosine Deaminase (ADA 1) in Human Tissues

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 2004 .

Autoimmune thyroid disease (Graves' disease and hashimoto's thyroiditis) in two patients with Crohn's disease: case reports and literature review.

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2005, Internal medicine.

Serum Cholinesterase Activities In Cases of Hypercholinesterasemia with isoenzymic Alteration

Tetsuya Yamamoto, K. Higashino, Y. Amuro, 2004 .

Tumor markers in pleural effusion diagnosis

Y. Moriwaki, T. Nakano, Tetsuya Yamamoto, 1988, Cancer.

Urinary excretion of pseudouridine in patients with hepatocellular carcinoma

Y. Moriwaki, T. Nakano, Tetsuya Yamamoto, 1986, Cancer.

Plasma concentrations and urinary excretion of purine bases (uric acid, hypoxanthine, and xanthine) and oxypurinol after rigorous exercise.

Y. Moriwaki, Y. Oku, Tetsuya Yamamoto, 2006, Metabolism: clinical and experimental.

Renal Excretions of Oxypurinol and Oxypurines — Effects of Pyrazinamide, Probenecid and Benzbromarone

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 1989 .

Relationship between plasma uridine and urinary urea excretion.

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2010, Metabolism: clinical and experimental.

Effect of octreotide acetate on the plasma concentration and urinary excretion of uridine and purine bases.

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 2002, Endocrine journal.

Effect of sauna bathing and beer ingestion on plasma concentrations of purine bases.

Y. Moriwaki, Jidong Cheng, Tetsuya Yamamoto, 2004, Metabolism: clinical and experimental.

Concomitant Cushing's Disease and Marked Hyperprolactinemia: Response to a Dopamine Receptor Agonist.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2016, Internal medicine.

High uric acid promotes dysfunction in pancreatic β cells by blocking IRS2/AKT signalling

Jidong Cheng, Tianliang Huang, Yaqiu Hu, 2020, Molecular and Cellular Endocrinology.

The effect of febuxostat to prevent a further reduction in renal function of patients with hyperuricemia who have never had gout and are complicated by chronic kidney disease stage 3: study protocol for a multicenter randomized controlled study

Tetsuya Yamamoto, Y. Tomino, Y. Shibagaki, 2014, Trials.

Sporadic Pseudohypoparathyroidism Type Ib With TSH Resistance: Identification of Methylation Defects Within the GNAS Gene

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2007 .

Direct evidence of autosomal recessive inheritance of Arg24 to termination codon in purine nucleoside phosphorylase gene in a family with a severe combined immunodeficiency patient

Y. Moriwaki, Tetsuya Yamamoto, Y. Sasaki, 1998, Human Genetics.

Insulin autoimmune syndrome in a patient with ANCA-associated glomerulonephritis

Y. Moriwaki, Tetsuya Yamamoto, T. Nakanishi, 2008, Diabetes, metabolic syndrome and obesity : targets and therapy.

High Uric Acid Induces Insulin Resistance in Cardiomyocytes In Vitro and In Vivo

Jidong Cheng, Yuzhang Zhu, Tianliang Huang, 2016, PloS one.

Human leukocyte antigen genotypes and antibody profiles associated with familial pemphigus in Japanese

Tetsuya Yamamoto, W. Fujimoto, Y. Aoyama, 2011, The Journal of dermatology.

Anaplastic thyroid carcinoma accompanied by uncontrollable eosinophilia.

S. Hirota, Y. Moriwaki, Tetsuya Yamamoto, 2015, Internal medicine.

Stepwise dose increase of febuxostat is comparable with colchicine prophylaxis for the prevention of gout flares during the initial phase of urate-lowering therapy: results from FORTUNE-1, a prospective, multicentre randomised study

A. Taniguchi, H. Yamanaka, Tetsuya Yamamoto, 2017, Annals of the rheumatic diseases.

Serum Macro TSH Level is Associated with Sleep Quality in Patients with Cardiovascular Risks – HSCAA Study

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2017, Scientific Reports.

A novel point mutation associated with alkaptonuria

Tetsuya Yamamoto, H. Imanishi, Weidong Liu, 1998, Clinical Genetics.

A Case of Subclinical Central Diabetes Insipidus Unmasked by Pregnancy

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2006 .

Associations of Sleep Quality and Awake Physical Activity with Fluctuations in Nocturnal Blood Pressure in Patients with Cardiovascular Risk Factors

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2016, PloS one.

Plasma leptin level is associated with cardiac autonomic dysfunction in patients with type 2 diabetes: HSCAA study

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2015, Cardiovascular Diabetology.

Urate-lowering therapy for CKD patients with asymptomatic hyperuricemia without proteinuria elucidated by attribute-based research in the FEATHER Study

Y. Moriwaki, S. Ito, H. Yamanaka, 2022, Scientific Reports.

Uric acid induces oxidative stress and growth inhibition by activating adenosine monophosphate-activated protein kinase and extracellular signal-regulated kinase signal pathways in pancreatic β cells

Bo-zhi Cai, Youfeng Li, Jidong Cheng, 2013, Molecular and Cellular Endocrinology.

Allopurinol Reduces Neointimal Hyperplasia in the Carotid Artery Ligation Model in Spontaneously Hypertensive Rats

I. Hisatome, Tetsuya Yamamoto, S. Sugihara, 2006, Hypertension Research.

Effects of topiroxostat on the serum urate levels and urinary albumin excretion in hyperuricemic stage 3 chronic kidney disease patients with or without gout

I. Hisatome, Tetsuya Yamamoto, T. Hosoya, 2014, Clinical and Experimental Nephrology.

Immunohistochemical Localization of Xanthine Oxidase in Human Tissues

Y. Moriwaki, Tetsuya Yamamoto, K. Higashino, 1996 .

Yogurt containing Lactobacillus gasseri PA-3 alleviates increases in serum uric acid concentration induced by purine ingestion: a randomized, double-blind, placebo-controlled study

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2018, GOUT AND NUCLEIC ACID METABOLISM.

High uric acid directly inhibits insulin signalling and induces insulin resistance.

Jidong Cheng, Chaohuan Luo, Zhi Li, 2014, Biochemical and biophysical research communications.

Plasma leptin concentration is associated with fatigue severity in patients with cardiovascular risk factors – HSCAA study

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2016, Psychoneuroendocrinology.

Plasma Brain-Derived Neurotrophic Factor and Reverse Dipping Pattern of Nocturnal Blood Pressure in Patients with Cardiovascular Risk Factors

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2014, PloS one.

Two Cases of Insulinoma Complicated With Adrenal Tumor: Adrenocorticotropic Hormone-Independent Cushing Syndrome and Nonfunctioning Adenoma

Y. Moriwaki, Tetsuya Yamamoto, J. Fujimoto, 2009 .

Oxidized low-density lipoprotein autoantibodies in patients with primary gout: effect of urate-lowering therapy.

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2004, Clinica chimica acta; international journal of clinical chemistry.

Autophagy protects against high uric acid-induced hepatic insulin resistance

Jidong Cheng, Tetsuya Yamamoto, H. Koyama, 2022, Molecular and Cellular Endocrinology.

High uric acid induces liver fat accumulation via ROS/JNK/AP-1 signaling.

Jidong Cheng, I. Hisatome, Tetsuya Yamamoto, 2021, American journal of physiology. Endocrinology and metabolism.

Autoimmune hepatitis or hepatic involvement in SLE?

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 1987, Gastroenterologia Japonica.

Placebo-controlled, double-blind study of the non-purine-selective xanthine oxidase inhibitor Febuxostat (TMX-67) in patients with hyperuricemia including those with gout in Japan: phase 3 clinical study.

H. Yamanaka, Toshitaka Nakamura, Tetsuya Yamamoto, 2011, Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.

‘Pseudohypouricosuria’ in Alcaptonuria: Homogentisic Acid Interference in the Measurement of Urinary Uric Acid with the Uricase — Peroxidase Reaction

Y. Moriwaki, Tetsuya Yamamoto, K. Higashino, 1999, Annals of clinical biochemistry.

Identification of a new point mutation in hypoxanthine phosphoribosyl transferase responsible for hyperuricemia in a female patient.

Y. Moriwaki, Jidong Cheng, Tetsuya Yamamoto, 2004, Metabolism: clinical and experimental.

Relationship between serum allantoin and urate in healthy subjects and effects of benzbromarone in gout patients.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2012, International journal of clinical pharmacology and therapeutics.

Metformin ameliorates high uric acid-induced insulin resistance in skeletal muscle cells

Jidong Cheng, Chaohuan Luo, Liangli Hong, 2017, Molecular and Cellular Endocrinology.

Identification of a new point mutation in the human molybdenum cofactor sulferase gene that is responsible for xanthinuria type II.

Y. Moriwaki, Jidong Cheng, Tetsuya Yamamoto, 2003, Metabolism: clinical and experimental.

Identification of a new point mutation in the human xanthine dehydrogenase gene responsible for a case of classical type I xanthinuria

Y. Moriwaki, Tetsuya Yamamoto, T. Hada, 2001, Human Genetics.

Acute Effects of Oral Tofisopam on Plasma Concentration and Urinary Excretion of Uric Acid and Oxypurinol "Preliminary Communication".

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2015, Current clinical pharmacology.

Comparative localization of aldehyde oxidase and xanthine oxidoreductase activity in rat tissues

Y. Moriwaki, Tetsuya Yamamoto, K. Higashino, 1998, The Histochemical Journal.

Enzymatic Histochemical Localization of Aldehyde Oxidase in Rat Liver by the Tetrazolium Method

Y. Moriwaki, Tetsuya Yamamoto, K. Higashino, 1997 .

Zonal Distribution of Allopurinol-Oxidizing Enzymes in Rat Liver

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 1998 .

53 – Effects of Beer Ingestion on Body Purine Bases

Y. Moriwaki, Tetsuya Yamamoto, 2009 .

[Definition and classification of hyperuricemia].

Tetsuya Yamamoto, 2008, Nihon rinsho. Japanese journal of clinical medicine.

Plasma brain-derived neurotrophic factor concentration is a predictor of chronic kidney disease in patients with cardiovascular risk factors – Hyogo Sleep Cardio-Autonomic Atherosclerosis study

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2017, PloS one.

Partial HPRT Deficiency with a Novel Mutation of the HPRT Gene in Combination with Four Previously Reported Variants Associated with Hyperuricemia.

Y. Moriwaki, Tetsuya Yamamoto, H. Koyama, 2015, Internal medicine.

Tumor markers in pleural effusion diagnosis

Y. Moriwaki, T. Nakano, Tetsuya Yamamoto, 1988, Cancer.

Compound heterozygous mutation of aquaporin 2 gene in woman patient with congenital nephrogenic diabetes insipidus.

Y. Moriwaki, Tetsuya Yamamoto, Sumio Takahashi, 2009, Internal medicine.