D. Witiak

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Modulation of carcinogenicity in 1,2,3,4-tetrahydro-7,12- dimethylbenz[a]anthracene (THDMBA) by fluorine substitution: crystal structures of the 5- and 6-fluoro regioisomers.

S. D. Black, P. Sharma, J. Gallucci, 1992, Carcinogenesis.

Potent antiplatelet effects of cyclic clofibric acid (CPIB) analogs on human platelets.

D. Witiak, K. Romstedt, S. Kim, 1989, Thrombosis research.

Comparative metabolism in vitro of a novel carcinogenic polycyclic aromatic hydrocarbon, 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene, and its two regioisomeric B-ring fluoro analogues.

S. D. Black, P. Sharma, S. J. Rinderle, 1992, Cancer research.

The crystal structure of (+)-d-tris(ethylenediamine)cobalt(III) nitrate

J. Clardy, D. Witiak, D. Martin, 1972 .

In vivo and in vitro peroxisome proliferation properties of selected clofibrate analogues in the rat. Structure-activity relationships.

D. Witiak, V. Tortorella, V. Kamanna, 1990, Biochemical pharmacology.

Disposition of clofibrate in the rat. Acute and chronic administration.

D. Witiak, J. Baldwin, D. Feller, 1980, Biochemical pharmacology.

Pharmacologic Effects of 4-Chlorophenol in Rats: Comparison to Clofibrate

D. Witiak, J. Hanson, H. A. Newman, 1989, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Cholesterol balance and fecal neutral steroid and bile acid excretion in normal men fed dietary fats of different fatty acid composition.

D. Witiak, W. Connor, D. B. Stone, 1969, The Journal of clinical investigation.

Beta-lapachone-mediated apoptosis in human promyelocytic leukemia (HL-60) and human prostate cancer cells: a p53-independent response.

G. Wilding, D. Witiak, D. Boothman, 1995, Cancer research.

Serum lipoprotein and apoprotein concentrations in 4-(4-chlorophenyl)-2-hydroxytetronic acid and clofibrate-treated cholesterol and cholic acid-fed rats

D. Witiak, V. Kamanna, H. A. Newman, 2006, Lipids.

Mouse skin tumor initiating activity of fluorinated derivatives of 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene.

P. Sharma, D. Witiak, J. DiGiovanni, 1992, Chemical research in toxicology.

Potent inhibitory activities of hydrophobic aci-reductones (2-hydroxytetronic acid analogs) against membrane and human low-density lipoprotein oxidation.

D. Witiak, A. Hopper, W. Weglicki, 1998, Biochemical pharmacology.

A Rapid Screening Test to Determine the Antioxidant Potencies of Natural and Synthetic Antioxidants.

W. Pryor, B. Tait, D. Witiak, 1993 .

Cytotoxicity, anchorage-independent growth, and DNA adduct formation in human neonatal fibroblasts by 1,2,3,4-tetrahydro-7,12-dimethylbenz(a)-anthracene (TH-DMBA), its six aryl fluoro regioisomers, and an exo methylene tautomer.

G. Milo, D. Witiak, H. Kumari, 1990, Teratogenesis, carcinogenesis, and mutagenesis.

Chapter 23. Calcium Antagonists

D. Witiak, W. Muir, R. Rahwan, 1981 .

Hypocholesterolemic agents. Compounds related to ethyl alpha-(4-chlorophenoxy)-alpha-methylpropionate.

D. Witiak, W. Connor, T. C. Ho, 1968, Journal of medicinal chemistry.

Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: I. Chow-fed animals

D. Witiak, J. Rice, H. A. Newman, 1981, Lipids.

Hypolipidemic effects of clofibrate and selected chroman analogs in fasted rats: II. High sucrose-fed animals

D. Witiak, J. Rice, H. A. Newman, 2006, Lipids.

Antilipidemic activity of 4-oxo-functionalized ethyl 6-chlorochroman-2-carboxylate analogs and a related tricyclic lactone in three rat models

D. Witiak, J. A. Minatelli, J. Baldwin, 2006, Lipids.

β -Lapachone-mediated Apoptosis in Human Promyelocytic Leukemia (HL-60) and Human Prostate Cancer Cells: A p53-independent Response 1

George, D. Witiak, D. Boothman, 2006 .

Induction of DNA topoisomerase II-mediated DNA cleavage by beta-lapachone and related naphthoquinones.

A. Liu, L. Liu, L. Marton, 1997, Cancer research.

Aci-reductones enhance interleukin-2-induced lymphocyte cytotoxicity.

D. Witiak, P. Triozzi, J. Rinehart, 1993, International journal of immunopharmacology.

Reduction of chronic doxorubicin cardiotoxicity in beagle dogs by bis-morpholinomethyl derivative of razoxane (ICRF-159)

V. Ferrans, D. Witiak, E. Herman, 2004, Cancer Chemotherapy and Pharmacology.

Comparison of hypocholesterolemic activity for cyclic analogs of clofibrate in normolipemic rats.

D. Witiak, D. Feller, A. Goldberg, 1977, Atherosclerosis.

Cholesterol 7alpha-hydroxylase--evidence for a distinct hepatic microsomal enzyme system.

D. Witiak, D. Feller, W. Mellon, 1978, Biochemical pharmacology.

Inhibition of topoisomerase II by ICRF-193, the meso isomer of 2,3-bis(2,6-dioxopiperazin-4-yl)butane. Critical dependence on 2,3-butanediyl linker absolute configuration.

D. Witiak, R. Snapka, A. Blokhin, 1996, Biochemical pharmacology.

Differential effect of clofibrate on hepatic drug oxidation and cholesterol 7alpha-hydroxylation.

D. Witiak, D. Feller, A. Goldberg, 1976, Biochemical pharmacology.

Synthesis of ethyl 6-substituted-chroman- and -chromone-2-carboxylates. A comparative structure-activity study employing the 6-phenyl and phenoxy analogs in the triton hyperlipidemic rat model.

D. Witiak, H. A. Newman, R. Cavestri, 1975, Journal of medicinal chemistry.

Tumor-initiating activity of 4-fluoro-7,12-dimethylbenz[a]anthracene and 1,2,3,4-tetrahydro-7,12-dimethylbenz[a]anthracene in female SENCAR mice.

T. Slaga, D. Witiak, J. DiGiovanni, 1982, Carcinogenesis.

Biological properties of ICRF-159 and related bis(dioxopiperazine) compounds.

D. Witiak, E. Herman, K. Hellmann, 1982, Advances in pharmacology and chemotherapy.

Comparative kinetics of cytosine nucleosides. Influence of a 6-methyl substituent on degradation rates and pathways in aqueous buffers.

D. Witiak, R. Notari, A. Lin, 1972, Journal of medicinal chemistry.

Hypocholesterolemic and antiaggregatory properties of 2-hydroxytetronic acid redox analogues an their relationship to clofibric acid.

D. Witiak, D. Feller, S. Patel, 1982, Journal of medicinal chemistry.

Vilsmeier-Haack cyclizations. Synthesis of 2-substituted 3-dimethylamino-5-6-methylenedioxyindenes and the corresponding indanones

David R. Williams, D. Witiak, S. Kakodkar, 1974 .

Intracellular localization of the calcium antagonist propyl-methylenedioxyindene in cardiac tissue.

D. Witiak, J. Lynch, R. Rahwan, 1983, General pharmacology.

Effect of three calcium antagonists on platelet secretion and metabolism.

D. Witiak, R. Rahwan, G. Stewart, 1981, Biochemical pharmacology.

Diethyl (4baalpha,4calpha,9aalpha,9balpha)-3,6-dichlorocyclobuta[1,2-b:3,4-b']bisbenzofuran-9a,9b(4bH,4cH)-dicarboxylate: the cis,syn photodimer of ethyl 5-chlorobenzofuran-2-carboxylate, an analogue related to the antilipidemic drug clofibrate.

D. Witiak, J. Baldwin, H. A. Newman, 1978, Journal of medicinal chemistry.

HYPOCHOLESTEROLEMIC AND ANTIAGGREGATORY PROPERTIES OF 2-HYDROXYTETRONIC ACID REDOX ANALOGS AND THEIR RELATIONSHIP TO CLOFIBRIC ACID

D. Witiak, D. Feller, Suman T. Patel, 1982 .

Dioxopiperazines: chemistry and biology.

D. Witiak, Y. Wei, Y. Wei, 1990, Progress in drug research. Fortschritte der Arzneimittelforschung. Progres des recherches pharmaceutiques.

Inhibitory action of -(4-chlorophenoxy)- -methylpropionic acid analogs on cholesterol biosynthesis and lipolysis in vitro.

D. Witiak, D. Feller, R. Hackney, 1971, Journal of medicinal chemistry.

SYNTHESIS OF ETHYL 6-SUBSTITUTED-CHROMAN- AND -CHROMONE-2-CARBOXYLATES. COMPARATIVE STRUCTURE-ACTIVITY STUDY EMPLOYING THE 6-PHENYL AND PHENOXY ANALOGS IN THE TRITON HYPERLIPIDEMIC RAT MODEL

D. Witiak, H. A. Newman, R. Cavestri, 1976 .

Synthesis and pharmacological evaluation of a clofibrate-related tricyclic spirolactone, 5-chloro-4',5-dihydrospiro[benzofuran-2(3H),3'(2'H)-furan]-2'-one.

D. Witiak, J. Baldwin, H. A. Newman, 1978, Journal of medicinal chemistry.

Comparative antilipidemic effects of various ethyl 5-substituted benzofuran-, 2,3-dihydrobenzofuran-, and 3(2H)-benzofuranone-2-carboxylate analogs of clofibrate in a triton hyperlipidemic rat model

D. Witiak, H. A. Newman, W. Loh, 1976, Lipids.

Synthetic approaches to 4-spiro-2-hydroxytetronic acids

D. Witiak, A. Tehim, 1987 .

A rapid screening test to determine the antioxidant potencies of natural and synthetic antioxidants

W. Pryor, B. Tait, D. Witiak, 1993 .

6-Chlorochroman-2-carboxylic acids. Synthesis and biological evaluation as antagonists for cholesterol biosynthesis and lipolysis in vitro.

D. Witiak, D. Feller, E. S. Stratford, 1971, Journal of medicinal chemistry.

Synthesis of All Distinct α-Methyl-Substituted Isomers of Amino Bis(2,2′-Ethanoic Acid) Diethyl Ester and Ethylene Diamine Tetraacetic Acid Tetraethyl Ester Scaffolds

D. Witiak, S. Insaf, 2000 .

Stereoselective syntheses of the trans-decahydroquinoline-5-carboxylic acid epimers. Diastereomeric zwitterionic probes of gamma-aminobutyric acid related biological properties in vitro and in vivo.

R. Patch, D. Witiak, S. Enna, 1986, Journal of medicinal chemistry.

Synthesis and antimetastatic properties of steroeoisomeric trycylic bis(dioxopiperazine) analogues in a B16 melanoma model.

D. Witiak, B. Zwilling, B. K. Trivedi, 1981, Journal of medicinal chemistry.

Syntheses and proton NMR conformational analyses of diastereomeric 4,4'-(4,5-dihydroxy-1,2-cyclohexanediyl)bis(2,6-piperazinedione)s and a synthetically related tricyclic octahydro-2,2-dimethyl-6-oxo-1,3-dioxolo[4,5-g]quinoxaline-5,8-diacetic acid ester

D. Witiak, Yong-Heng Wei, 1991 .

Mono and bis(bioreductive) alkylating agents: synthesis and antitumor activities in a B16 melanoma model.

D. Witiak, S. Ananthan, V. Verhoef, 1989, Journal of medicinal chemistry.

A study of steric and electronic factors governing the position of biofunctionalization of the benz(a)anthracene nucleus: Metabolism in vitro of fluoro- and methyl-substituted analogs

Y. M. Sheikh, D. Witiak, R. Hart, 1981 .

Inhibitors of Cyclooxygenase and 5-Lipoxygenase

D. Witiak, Padmaja Mantri, 1994, Current Medicinal Chemistry.

Carbinolamines and related structures--potential alkylating metabolites of clinically active anticancer drugs.

D. Witiak, A. Soloway, R. J. Brumbaugh, 1983, Journal of theoretical biology.

Effects of pure capsaicinoids (capsaicin and dihydrocapsaicin) on plasma lipid and lipoprotein concentrations of turkey poults.

D. Witiak, J. A. Negulesco, H. A. Newman, 1987, Atherosclerosis.

Comparative metabolism and DNA binding of 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog.

D. Witiak, F. Daniel, S. D'Ambrosio, 1979, Cancer letters.

Effect of high-speed rolling on herpes simplex virus detection and replication

D. Witiak, J. Hughes, C. T. Mavromoustakis, 1988, Journal of clinical microbiology.

Effect of rolling on foci development and viral replication for herpes simplex virus (HSV).

D. Witiak, J. Hughes, C. T. Mavromoustakis, 1988, Journal of virological methods.

Antiviral activity of antilipidemic compounds on herpes simplex virus type 1

D. Witiak, V. Hamparian, J. Hughes, 1980, Antimicrobial Agents and Chemotherapy.

DNA repair in Syrian hamster embryo cells treated with 7,12-dimethylbenz[a]anthracene and its weakly carcinogenic 5-fluoro analog.

D. Witiak, F. Daniel, S. D'Ambrosio, 1979, Cancer letters.

Study of trans-cyclopropylbis (diketopiperazine) and chelating agents related to ICRF 159. Cytotoxicity, mutagenicity, and effects on scheduled and unscheduled DNA synthesis.

D. Witiak, H. Lee, R. Hart, 1977, Journal of medicinal chemistry.

Inhibition of low density lipoprotein oxidation by thyronines and probucol.

D. Witiak, H. A. Newman, D. Feller, 1993, Biochemical pharmacology.

Pyrazole product ratio analysis of the reaction of diazomethane with methyl cis- and trans-beta-chloroacrylates.

D. Witiak, B. Sinha, 1970, The Journal of organic chemistry.

Inhibitors and stimulators of cholesterolgenesis enzymes. A structure-activity study in vitro of amino and selected N-containing analogs of 5 -cholestane-3 ,5 ,6 -triol.

D. Witiak, M. Ritter, M. Dempsey, 1971, Journal of medicinal chemistry.

Synthesis and P-388 antitumor properties of the four diastereomeric 1-hydroxy-3,4-diaminocyclohexane-Cl2PtII complexes.

J. Gallucci, D. Witiak, Y. Wei, 1989, Journal of medicinal chemistry.

Absorption, Distribution, Metabolism, and Elimination of Antihistamines

D. Witiak, N. Lewis, 1978 .

Pharmacological evaluation of new calcium antagonists: 2-substituted 3-dimethylamino-5,6-methylenedioxyindenes.

D. Witiak, R. Rahwan, M. Faust, 1977, The Journal of pharmacology and experimental therapeutics.

A convenient synthesis of ethyl‐14C‐isocyanate

D. Witiak, F. D. Cazer, 1975 .

Biological significance of serum albumin binding parameters determined in vitro for clofibrate-related hypolipemic drugs: use of 2-(4'-hydroxybenzeneazo)benzoic acid to mirror L-thyroxine binding to and displacement from serum albumins.

D. Witiak, A. Hopper, T. Sokoloski, 1974, Journal of pharmaceutical sciences.

Differential effects of benzodioxane, chroman and dihydrobenzofuran analogs of clofibrate in a triton hyperlipemic rat model

D. Witiak, H. A. Newman, William P. Hellman, 1973, Lipids.

Characteristics of benzo[a]pyrene and A-ring reduced 7,12-dimethyl benz[a]anthracene induced neoplastic transformation of human cells in vitro.

G. Milo, D. Witiak, F. D. Cazer, 1981, Cancer letters.

Comparison of the protective effect of ICRF-187 and structurally related analogues against acute daunorubicin toxicity in Syrian golden hamsters.

V. Ferrans, D. Witiak, E. Herman, 1985, Research communications in chemical pathology and pharmacology.

Design, combinatorial chemical synthesis and in vitro characterization of novel urea based gelatinase inhibitors.

J. Houtman, D. Witiak, P. Bertics, 1999, Bioorganic & medicinal chemistry letters.

Nuclear Magnetic Resonance. Influence of Substituents on the Long-Range Spin-Spin Coupling Constant between Benzylic and Ring Protons in the Orcinol Series

D. Witiak, Youlin Lin, Dhun Patel, 1967 .

Effects of clofibrate and 6-substituted chroman analogs on human platelet function: mechanism of inhibitory action.

D. Witiak, H. A. Newman, D. Feller, 1981, Biochemical pharmacology.

Potentiating effects of clofibrate on prostaglandin-dependent and -independent pathways of human platelet activation: evidence for involvement of cyclic AMP.

D. Witiak, R. Fertel, H. A. Newman, 1982, Biochemical pharmacology.

A comparative study of dimethylhydrazine regioisomers and the methylazoxymethanol metabolite of 1,1- and 1,2-dimethylhydrazine in relation to transformation in human fibroblasts.

G. Milo, D. Witiak, S. D'Ambrosio, 1985, Cancer letters.

Differential effects of benzodioxane, chroman, and dihydrobenzofuran analogs of clofibrate on various parameters of hepatic drug metabolism.

D. Witiak, N. Lewis, D. Feller, 1974, Journal of medicinal chemistry.

STUDY OF TRANS-CYCLOPROPYLBIS(DIKETOPIPERAZINE) AND CHELATING AGENTS RELATED TO ICRF 159. CYTOTOXICITY, MUTAGENICITY, AND EFFECTS ON SCHEDULED AND UNSCHEDULED DNA SYNTHESIS

D. Witiak, Hee-Joo Lee, R. Hart, 1977 .

Influence of Clofibrate (Ethyl-4-Chlorophenoxyisobutyrate) on Hepatic Drug Metabolism in Male Rats 1

D. Witiak, N. Lewis, D. Feller, 1974, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

Effects of 2‐Substituted 3‐Dimethylamino‐5,6‐Methylenedioxyindenes on Calcium‐Induced Arrhythmias

D. Witiak, J. Lynch, R. Rahwan, 1981, Journal of cardiovascular pharmacology.

Synthesis and antimetastatic properties of stereoisomeric tricyclic bis(dioxopiperazines) in the Lewis lung carcinoma model.

D. Witiak, R. V. Nair, F. Schmid, 1985, Journal of medicinal chemistry.

The role of calcium antagonism in the therapeutic action of drugs.

D. Witiak, R. Rahwan, M. F. Piascik, 1979, Canadian journal of physiology and pharmacology.

aci-Reductones: Drug design, enantioselective syntheses and biological activities within lipid membranes

D. Witiak, A. Hopper, A. Blokhin, 1997 .

Differential eudismic ratios in the antagonism of human platelet function by phenoxy- and thiophenoxyacetic acids.

D. Witiak, F. Loiodice, V. Tortorella, 1996, Farmaco.

Dissociation of hypolipidemic and antiplatelet actions from adverse myotonic effects of clofibric acid related enantiomers.

D. Witiak, F. Loiodice, V. Tortorella, 1987, Journal of medicinal chemistry.