J. Guan

发表

In vitro scratch assay: a convenient and inexpensive method for analysis of cell migration in vitro

C. Liang, Ann Y Park, J. Guan, 2007, Nature Protocols.

Autophagic lipid metabolism sustains mTORC1 activity in TSC-deficient neural stem cells

J. Guan, D. Plas, Chenran Wang, 2019, Nature Metabolism.

Tsc1 Regulates the Balance Between Osteoblast and Adipocyte Differentiation Through Autophagy/Notch1/β‐Catenin Cascade

J. Guan, Han Kyoung Choi, Hebao Yuan, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling.

J. Guan, Song Chen, Fei Liu, 2015, Cancer cell.

Hyperactivation of Mammalian Target of Rapamycin Complex 1 (mTORC1) Promotes Breast Cancer Progression through Enhancing Glucose Starvation-induced Autophagy and Akt Signaling*

Fei Liu, Yongqiang Chen, J. Guan, 2013, The Journal of Biological Chemistry.

Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways

J. Guan, B. Gan, Xu Peng, 2006, The Journal of cell biology.

Association of Focal Adhesion Kinase with Tuberous Sclerosis Complex 2 in the Regulation of S6 Kinase Activation and Cell Growth*

J. Guan, B. Gan, Y. Yoo, 2006, Journal of Biological Chemistry.

Using microfluidic channel networks to generate gradients for studying cell migration.

E. Bodenschatz, J. Guan, L. Song, 2005, Methods in molecular biology.

Guidelines for the use and interpretation of assays for monitoring autophagy

Robert Clarke, Hong Jiang, Hiroyuki Ishida, 2012 .

Biochemistry and biomechanics of cell motility.

Shu Chien, S. Chien, J. Guan, 2005, Annual review of biomedical engineering.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Interaction of Focal Adhesion Kinase with Cytoskeletal Protein Talin (*)

J. Parsons, J. Guan, J. Hildebrand, 1995, The Journal of Biological Chemistry.

Autophagy Regulates Craniofacial Bone Acquisition

Li Wang, Y. Mishina, J. Guan, 2019, Calcified Tissue International.

Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration*

C. Liang, J. Guan, Chenran Wang, 2009, The Journal of Biological Chemistry.

Regulation of focal adhesion-associated protein tyrosine kinase by both cellular adhesion and oncogenic transformation

D. Shalloway, J. Guan, 1992, Nature.

Association of Focal Adhesion Kinase with Grb7 and Its Role in Cell Migration*

J. Guan, D. Han, D. C. Han, 1999, The Journal of Biological Chemistry.

Breast Cancer: Multiple Subtypes within a Tumor?

J. Guan, S. Yeo, Jun-Lin Guan, 2017, Trends in cancer.

A Novel Role of the Actin-nucleating Arp2/3 Complex in the Regulation of RNA Polymerase II-dependent Transcription*

J. Guan, Y. Yoo, Xiaoyang Wu, 2007, Journal of Biological Chemistry.

MMTV-cre;Ccn6 knockout mice develop tumors recapitulating human metaplastic breast carcinomas

J. Guan, C. Kleer, T. Anwar, 2016, Oncogene.

FAK Promotes Osteoblast Progenitor Cell Proliferation and Differentiation by Enhancing Wnt Signaling

Li Wang, J. Guan, Hebao Yuan, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Neuronal Wiskott‐Aldrich syndrome protein regulates TGF‐β1‐mediated lung vascular permeability

S. Snapper, J. Guan, J. Pittet, 2016, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Neuronal Wiskott-Aldrich syndrome protein (N-WASP) is critical for formation of α-smooth muscle actin filaments during myofibroblast differentiation.

J. Guan, L. Reichardt, V. Thannickal, 2012, American journal of physiology. Lung cellular and molecular physiology.

Regulation of RNA-polymerase-II-dependent transcription by N-WASP and its nuclear-binding partners

J. Guan, Gang Liu, Y. Yoo, 2006, Nature Cell Biology.

Sumoylation Delimits KLF8 Transcriptional Activity Associated with the Cell Cycle Regulation*

Alison M. Urvalek, J. Guan, B. Gan, 2006, Journal of Biological Chemistry.

Cleavage of Focal Adhesion Kinase by Caspases during Apoptosis*

G. Rosen, J. Guan, K. Orth, 1997, The Journal of Biological Chemistry.

FIP200 Suppresses Immune Checkpoint Therapy Responses in Breast Cancers by Limiting AZI2/TBK1/IRF Signaling Independent of Its Canonical Autophagy Function

J. Guan, Michael A. Haas, S. Yeo, 2020, Cancer Research.

14‐3‐3 regulation of cell spreading and migration requires a functional amphipathic groove

J. Guan, L. G. Rodríguez, 2005, Journal of cellular physiology.

p62/SQSTM1 synergizes with autophagy for tumor growth in vivo

C. Croce, J. Guan, Chenran Wang, 2014, Genes & development.

Focal adhesion kinase in integrin-mediated signaling.

J. Guan, L. Cary, 1999, Frontiers in bioscience : a journal and virtual library.

Autophagy Induced by Calcium Phosphate Precipitates Involves Endoplasmic Reticulum Membranes in Autophagosome Biogenesis

X. Chen, Wentao Gao, J. Guan, 2012, PloS one.

FIP 200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells

S. Morrison, J. Guan, Fei Liu, 2010 .

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.

S. Morrison, J. Guan, Fei Liu, 2010, Blood.

Role of cell surface heparan sulfate proteoglycans in endothelial cell migration and mechanotransduction

Luke P. Lee, J. Guan, Song Li, 2005, Journal of cellular physiology.

FAK-mediated src phosphorylation of endophilin A2 inhibits endocytosis of MT1-MMP and promotes ECM degradation.

J. Guan, B. Gan, Y. Yoo, 2005, Developmental cell.

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella

S. Akira, T. Noda, J. Guan, 2011, Molecular biology of the cell.

Cell biology. Integrins, rafts, Rac, and Rho.

J. Guan, 2004, Science.

Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation

Maxim N. Artyomov, D. Green, S. Akira, 2016, Cell Host & Microbe.

Quantitative analysis of interactive behavior of mitochondria and lysosomes using structured illumination microscopy.

J. Guan, Chenran Wang, Ruilin Guan, 2020, Biomaterials.

Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin

S. Akira, T. Haraguchi, J. Guan, 2013, The Journal of cell biology.

Molecular mechanisms of Streptococcus pneumoniae‐targeted autophagy via pneumolysin, Golgi‐resident Rab41, and Nedd4‐1‐mediated K63‐linked ubiquitination

H. Morita, A. Ryo, M. Ohnishi, 2018, Cellular microbiology.

Targeting Autophagy in Thyroid Cancer: EMT, Apoptosis, and Cancer Stem Cells

J. Guan, S. Yeo, Tammy M. Holm, 2022, Frontiers in Cell and Developmental Biology.

Compensatory Function of Pyk2 Protein in the Promotion of Focal Adhesion Kinase (FAK)-null Mammary Cancer Stem Cell Tumorigenicity and Metastatic Activity*

J. Guan, Huaping Fan, 2011, The Journal of Biological Chemistry.

Autophagy is dispensable for Kmt2a/Mll-Mllt3/Af9 AML maintenance and anti-leukemic effect of chloroquine

J. Guan, Yi Zheng, Song Chen, 2017, Autophagy.

Autophagy Differentially Regulates Distinct Breast Cancer Stem-like Cells in Murine Models via EGFR/Stat3 and Tgfβ/Smad Signaling.

J. Guan, S. Yeo, Song Chen, 2016, Cancer research.

Association of Grb7 with Phosphoinositides and Its Role in the Regulation of Cell Migration*

J. Guan, D. Han, Tang-Long Shen, 2002, The Journal of Biological Chemistry.

Super-resolution observation of lysosomal dynamics with fluorescent gold nanoparticles

J. Guan, Kangqiang Qiu, H. Chao, 2020, Theranostics.

AMPK Inhibits ULK1-Dependent Autophagosome Formation and Lysosomal Acidification via Distinct Mechanisms

J. Guan, E. Chan, L. Gallagher, 2018, Molecular and Cellular Biology.

Autophagy deficiency by hepatic FIP200 deletion uncouples steatosis from liver injury in NAFLD.

Jiandie D. Lin, J. Guan, Ji‐Xin Cheng, 2013, Molecular endocrinology.

The ALS-FTD-linked gene product, C9orf72, regulates neuronal morphogenesis via autophagy

Huilin Zhou, J. Guan, Song Chen, 2019, Autophagy.

TRIM27 cooperates with STK38L to inhibit ULK1‐mediated autophagy and promote tumorigenesis

J. Guan, Xu Dong Zhang, R. Thorne, 2022, The EMBO journal.

Distinct roles of autophagy-dependent and -independent functions of FIP200 revealed by generation and analysis of a mutant knock-in mouse model

J. Guan, Chenran Wang, S. Yeo, 2016, Genes & development.

Inactivation of FIP200 Leads to Inflammatory Skin Disorder, but Not Tumorigenesis, in Conditional Knock-out Mouse Models*

J. Guan, B. Gan, Huijun Wei, 2009, Journal of Biological Chemistry.

Nuclear Focal Adhesion Kinase Controls Vascular Smooth Muscle Cell Proliferation and Neointimal Hyperplasia Through GATA4-mediated Cyclin D1 Transcription.

T. Lincoln, J. Guan, S. Lim, 2019, Circulation research.

Direct homophilic interaction of LAMP2A with the two-domain architecture revealed by site-directed photo-crosslinks and steric hindrances in mammalian cells

S. Yokoyama, K. Sakamoto, J. Guan, 2021, Autophagy.

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor alpha 4 beta 1.

R. Hynes, J. Guan, 1990, Cell.

Role of Grb7 Targeting to Focal Contacts and Its Phosphorylation by Focal Adhesion Kinase in Regulation of Cell Migration*

J. Guan, D. Han, Tang-Long Shen, 2000, The Journal of Biological Chemistry.

Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore

J. Guan, Chenran Wang, Ruilin Guan, 2018, bioRxiv.

An EGFR/Src-dependent β4 integrin/FAK complex contributes to malignancy of breast cancer

I. Lai, J. Guan, J. Liou, 2015, Scientific Reports.

Supercritical fluid chromatography-mass spectrometry enables simultaneous measurement of all phosphoinositide regioisomers

J. Guan, H. Arai, N. Kono, 2022, Communications Chemistry.

Mapping ofthefunctional determinants oftheintegrin *,cytoplasmic domainbysite-directed mutagenesis

J. Guan, 1990 .

Expression of normal and mutant avian integrin subunits in rodent cells [published erratum appears in J Cell Biol 1989 Oct;109(4 Pt 1):1187]

R. Hynes, J. Guan, J. Solowska, 1989, The Journal of cell biology.

Effects of altered cytoplasmic domains on transport of the vesicular stomatitis virus glycoprotein are transferable to other proteins

J. Guan, H. Cao, J. Rose, 1988, Molecular and cellular biology.

Male germline recombination of a conditional allele by the widely used Dermo1‐cre (Twist2‐cre) transgene

Li Wang, Y. Mishina, J. Guan, 2017, Genesis.

Inhibition of podocyte FAK protects against proteinuria and foot process effacement.

S. Hatakeyama, J. Guan, Zhiheng Yu, 2010, Journal of the American Society of Nephrology : JASN.

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

J. Guan, S. Lim, Xiao Lei Chen, 2008, The Journal of cell biology.

Cardiac developmental defects and eccentric right ventricular hypertrophy in cardiomyocyte focal adhesion kinase (FAK) conditional knockout mice

S. Chien, Ann Y Park, J. Guan, 2008, Proceedings of the National Academy of Sciences.

FIP200 restricts RNA virus infection by facilitating RIG-I activation

J. Guan, J. Ritchey, Shitao Li, 2021, Communications Biology.

Role of focal adhesion kinase in signaling by the extracellular matrix.

J. Guan, J. Zhao, J. Zhao, 2000, Progress in molecular and subcellular biology.

Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities.

J. Guan, M. Bonini, S. Predescu, 2013, American journal of physiology. Lung cellular and molecular physiology.

Suppression of Pyk2 Kinase and Cellular Activities by Fip200

H. Ueda, J. Guan, C. Zheng, 2000, The Journal of cell biology.

Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization

A. Ryo, M. Ohnishi, J. Guan, 2020, Communications Biology.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Pro-tumorigenic function of autophagy in mammary oncogenesis

J. Guan, Huijun Wei, 2012, Autophagy.

p27Kip1 and Cyclin D1 Are Necessary for Focal Adhesion Kinase Regulation of Cell Cycle Progression in Glioblastoma Cells Propagated in Vitro and in Vivo in the Scid Mouse Brain*

J. Guan, Q. Ding, M. Nelson, 2005, Journal of Biological Chemistry.

Autophagy mediated lipid catabolism facilitates glioma progression to overcome bioenergetic crisis

J. Guan, D. Plas, Chenran Wang, 2021, British Journal of Cancer.

Suppression of Pyk 2 Kinase and Cellular Activities by FIP 200

H. Ueda, J. Guan, C. Zheng, 2000 .

Cell Death | Autophagy in Fungi and Mammals

D. Klionsky, J. Guan, Sarah C. Stainbrook, 2021, Encyclopedia of Biological Chemistry III.

Retroviral expression of alternatively spliced forms of rat fibronectin

R. Hynes, J. Guan, J. E. Trevithick, 1990, The Journal of cell biology.

Transcriptional activation of cyclin D1 promoter by FAK contributes to cell cycle progression.

J. Guan, J. Zhao, R. Pestell, 2001, Molecular biology of the cell.

Title Compensatory role for Pyk 2 during angiogenesis in adult mice lacking endothelial cell

J. Guan, S. Lim, Xiao Lei Chen, 2008 .

Invited Review Integrin-mediated signal transduction pathways

J. Guan, D. C. Han, L. Cary, 2011 .

Requirement of Phosphatidylinositol 3-Kinase in Focal Adhesion Kinase-promoted Cell Migration*

J. Guan, Hong-Chen Chen, L. Cary, 1999, The Journal of Biological Chemistry.

Regulation of focal adhesion kinase by a novel protein inhibitor FIP200.

Hiroki Ueda, Jihe Zhao, H. Ueda, 2002, Molecular biology of the cell.

Role of FIP200 in inflammatory processes beyond its canonical autophagy function.

J. Guan, Chenran Wang, S. Yeo, 2020, Biochemical Society transactions.

Differential Regulation of Pyk2 and Focal Adhesion Kinase (FAK)

J. Guan, A. Akbay, Chunmei Guo, 1998, The Journal of Biological Chemistry.

Quantitative Analysis of Interactive Behavior of Mitochondria and Lysosomes Using Structured Illumination Microscopy

J. Guan, Chenran Wang, J. Diao, 2018, bioRxiv.

Kindlin-2 Tyrosine Phosphorylation and Interaction with Src Serve as a Regulatable Switch in the Integrin Outside-in Signaling Circuit*

J. Guan, G. Xiao, Y. Tu, 2014, The Journal of Biological Chemistry.

Impaired autophagy in macrophages promotes inflammatory eye disease

R. Xavier, S. Akira, J. Guan, 2016, Autophagy.

Integrin-mediated signal transduction pathways.

J. Guan, D. C. Han, L. Cary, 1999, Histology and histopathology.

Detection of focal adhesion kinase activation at membrane microdomains by fluorescence resonance energy transfer.

S. Chien, J. Guan, D. Schlaepfer, 2011, Nature communications.

Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts

J. Guan, Tang-Long Shen, 2001, FEBS letters.

Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain

H. Kung, J. Guan, Y. Qiu, 2001, Nature Cell Biology.

Transformation and pp60v-src autophosphorylation correlate with SHC-GRB2 complex formation in rat and chicken cells expressing host-range and kinase-active, transformation-defective alleles of v-src.

J. Guan, K. M. Woods Ignatoski, M. Verderame, 1995, Molecular biology of the cell.

Glycosylation allows cell-surface transport of an anchored secretory protein

J. Guan, C. Machamer, J. Rose, 1985, Cell.

Analysis of FAK‐associated signaling pathways in the regulation of cell cycle progression

J. Guan, D. Han, Jihe Zhao, 2000, FEBS letters.

Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival

N. Alon, E. White, J. Debnath, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer.

J. Guan, Song Chen, 2013, Cancer discovery.

Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells

T. Takebe, J. Guan, Yuncong Chen, 2021, Nature Communications.

Role of Calcium, the Actin Skeleton, and Lipid Structures in Signaling and Cell Motility

J. Guan, 2015 .

Focal adhesion kinase and Src phosphorylations in HGF-induced proliferation and invasion of human cholangiocarcinoma cell line, HuCCA-1.

J. Guan, V. Leardkamolkarn, U. Pongchairerk, 2005, World journal of gastroenterology.

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.

D. Birnbaum, G. Dontu, M. Wicha, 2010, The Journal of clinical investigation.

Autophagy in Fungi and Mammals

D. Klionsky, J. Guan, Jiefei Geng, 2004 .

Regulation of RB1CC1/FIP200 stability and autophagy function by CREBBP-mediated acetylation in an intrinsically disordered region

J. Guan, Michael A. Haas, Fuchun Yang, 2022, Autophagy.

An ER-targeted "reserve-release" fluorogen for topological quantification of reticulophagy.

J. Guan, Yuncong Chen, Kangqiang Qiu, 2022, Biomaterials.

Light-activated mitochondrial fission through optogenetic control of mitochondria-lysosome contacts

J. Guan, Kangqiang Qiu, J. Diao, 2022, Nature Communications.

Mammary Epithelial-specific Deletion of the Focal Adhesion Kinase Gene Leads to Severe Lobulo-Alveolar Hypoplasia and Secretory Immaturity of the Murine Mammary Gland*

J. Guan, B. Gan, Huijun Wei, 2007, Journal of Biological Chemistry.

Mapping of the functional determinants of the integrin beta 1 cytoplasmic domain by site-directed mutagenesis.

R. Hynes, J. Guan, E. Marcantonio, 1990, Cell regulation.

Integrin Receptor Signaling Pathways

J. Guan, Heinz R. Reiske, 2002 .

Residues within the First Subdomain of the FERM-like Domain in Focal Adhesion Kinase Are Important in Its Regulation*

J. Guan, Lee Ann Cohen, 2005, Journal of Biological Chemistry.

The association of focal adhesion kinase with a 200-kDa protein that is tyrosine phosphorylated in response to platelet-derived growth factor.

J. Guan, H. C. Chen, H. Chen, 1996, European journal of biochemistry.

Wound-healing assay.

J. Guan, Jun-Lin Guan, Xiaoyang Wu, 2005, Methods in molecular biology.

Association of focal adhesion kinase with its potential substrate phosphatidylinositol 3-kinase.

J. Guan, Hong-Chen Chen, H. C. Chen, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Direct interaction of v-Src with the focal adhesion kinase mediated by the Src SH2 domain.

S. J. Taylor, D. Shalloway, J. Guan, 1994, Molecular biology of the cell.

An MBoC Favorite: Fibronectin/integrin interaction induces tyrosine phosphorylation of a 120-kDa protein

R. Hynes, J. Guan, J. E. Trevithick, 1991, Molecular biology of the cell.

Simultaneous Zn2+ tracking in multiple organelles using super-resolution morphology-correlated organelle identification in living cells

T. Takebe, J. Guan, Zijian Guo, 2021, Nature Communications.

Focal adhesion kinase and its signaling pathways in cell migration and angiogenesis.

J. Guan, Jun-Lin Guan, Xiaofeng Zhao, 2011, Advanced drug delivery reviews.

Autophagy proteins control goblet cell function by potentiating reactive oxygen species production

Hiroyuki Miyoshi, Shizuo Akira, S. Akira, 2013, The EMBO journal.

Autophagy inhibition re-sensitizes pulse stimulation-selected paclitaxel-resistant triple negative breast cancer cells to chemotherapy-induced apoptosis

J. Guan, Chenran Wang, Michael A. Haas, 2015, Breast Cancer Research and Treatment.

LC3‐association with the parasitophorous vacuole membrane of Plasmodium berghei liver stages follows a noncanonical autophagy pathway

J. Guan, V. Heussler, Shahid M. Khan, 2017, Cellular microbiology.

Focal adhesion kinase in integrin signaling.

J. Guan, J L Guan, Jun-Lin Guan, 1997, Matrix biology : journal of the International Society for Matrix Biology.

Identification of FIP200 interaction with the TSC1–TSC2 complex and its role in regulation of cell size control

K. Guan, J. Guan, B. Gan, 2005, The Journal of cell biology.

Analysis of the calcium-dependent regulation of proline-rich tyrosine kinase 2 by gonadotropin-releasing hormone.

K. H. Allen, J. Guan, A. Navratil, 2008, Molecular endocrinology.

Regulation of the Cell Cycle by Focal Adhesion Kinase

J. Guan, Jihe Zhao, Heinz R. Reiske, 1998, The Journal of cell biology.

Toward a genetic analysis of cell-matrix adhesion.

R. Hynes, J. Guan, E. L. George, 1992, Cold Spring Harbor symposia on quantitative biology.

Lymphoid cells recognize an alternatively spliced segment of fibronectin via the integrin receptor α 4 β 1

Richard O. Hynes, R. Hynes, J. Guan, 1990, Cell.

Signal transduction by focal adhesion kinase in cancer

Jihe Zhao, J. Guan, Jun-Lin Guan, 2009, Cancer and Metastasis Reviews.

FAK signaling in Cancer-Associated Fibroblasts promotes breast cancer cell migration and metastasis by exosomal miRNAs-mediated intercellular communication

J. Guan, S. Yeo, M. Hao, 2020, Oncogene.

Focal Adhesion Kinase Activates Stat1 in Integrin-mediated Cell Migration and Adhesion*

Xin-Yuan Fu, J. Guan, M. Kitagawa, 2001, The Journal of Biological Chemistry.

Molecular characterization of LC3-associated phagocytosis reveals distinct roles for Rubicon, NOX2 and autophagy proteins

D. Green, J. Guan, R. Orchard, 2015, Nature Cell Biology.

Recognition of RNA N6-methyladenosine by IGF2BP Proteins Enhances mRNA Stability and Translation

Stefan Hüttelmaier, Miao Sun, Chuan He, 2018, Nature Cell Biology.

FIP200, an essential component of mammalian autophagy is indispensible for fetal hematopoiesis

Fei Liu, J. Guan, Fei Liu, 2011, Autophagy.

Nutrient-dependent mTORC1 association with the ULK1-Atg13-FIP200 complex required for autophagy.

J. Guan, T. Natsume, S. Iemura, 2009, Molecular biology of the cell.

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

J. Guan, T. Natsume, S. Iemura, 2008, The Journal of cell biology.

Suppression of autophagy by FIP200 deletion inhibits mammary tumorigenesis.

J. Guan, B. Gan, Huijun Wei, 2011, Genes & development.

Autophagy in stem cells

J. Menéndez, J. Guan, E. Wolvetang, 2013, Autophagy.

Streptococcus pneumoniae triggers hierarchical autophagy through reprogramming of LAPosome-like vesicles via NDP52-delocalization

A. Ryo, M. Ohnishi, J. Guan, 2020, Communications Biology.

FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors

J. Guan, S. Yeo, Ming Luo, 2020, Breast Cancer Research.

Phosphorylation of Tyrosine 397 in Focal Adhesion Kinase Is Required for Binding Phosphatidylinositol 3-Kinase*

J. Guan, H. Isoda, Hong-Chen Chen, 1996, The Journal of Biological Chemistry.

Role of Focal Adhesion Kinase Ser-732 Phosphorylation in Centrosome Function during Mitosis*

S. Chien, Ann Y Park, J. Guan, 2009, Journal of Biological Chemistry.

Blocking tumor growth by targeting autophagy and SQSTM1 in vivo

J. Guan, Huijun Wei, 2015, Autophagy.

Publisher Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Hailing Shi, Chuan He, Jianjun Chen, 2020, Nature Cell Biology.

Single-cell RNA-sequencing reveals distinct patterns of cell state heterogeneity in mouse models of breast cancer

L. Lu, J. Guan, S. Yeo, 2020, eLife.

Single-Cell Transcriptomic Analysis of Mammary Tumors Reveals Distinct Patterns of Hierarchical and Subtype Heterogeneity

J. Guan, T. Okamoto, Xiaoting Zhu, 2019, SSRN Electronic Journal.

Autophagy Is Required for Maturation of Surfactant-Containing Lamellar Bodies in the Lung and Swim Bladder.

Y. Miki, M. Murakami, A. Aiba, 2020, Cell reports.

Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation

S. Goldstein, Yongqiang Chen, J. Guan, 2013, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Gang Xiao, Gang Huang, Miao Sun, 2019, Nature.

Suppression of FIP200 and autophagy by tumor-derived lactate promotes naïve T cell apoptosis and affects tumor immunity

J. Guan, You-Wen He, Wei Wang, 2017, Science Immunology.

Inhibition of Integrin-mediated Cell Adhesion but Not Directional Cell Migration Requires Catalytic Activity of EphB3 Receptor Tyrosine Kinase

J. Guan, E. Pasquale, H. Miao, 2005, Journal of Biological Chemistry.

Identification of p130Cas as a Mediator of Focal Adhesion Kinase–promoted Cell Migration

S. Hanks, J. Guan, D. Han, 1998, The Journal of cell biology.

Tyrosine Phosphorylation of Growth Factor Receptor-bound Protein-7 by Focal Adhesion Kinase in the Regulation of Cell Migration, Proliferation, and Tumorigenesis*

J. Guan, Ling Huang, Chun-Hua Hsu, 2009, The Journal of Biological Chemistry.

The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions

J. Guan, D. Han, Tang-Long Shen, 2001, Oncogene.

Melanoma chondroitin sulphate proteoglycan regulates cell spreading through Cdc42, Ack-1 and p130cas

L. Lim, P. Keely, J. Guan, 1999, Nature Cell Biology.

Focal Adhesion Kinase Regulation of N-WASP Subcellular Localization and Function*

T. Takenawa, J. Guan, S. Suetsugu, 2004, Journal of Biological Chemistry.

Deletion of autophagy inducer RB1CC1 results in degeneration of the retinal pigment epithelium

S. Mitter, D. Klionsky, M. Boulton, 2015, Autophagy.

Focal adhesion kinase: a prominent determinant in breast cancer initiation, progression and metastasis.

J. Guan, Ming Luo, 2010, Cancer letters.

Elevated p62/SQSTM1 determines the fate of autophagy-deficient neural stem cells by increasing superoxide

E. White, J. Guan, H. Virgin, 2016, The Journal of cell biology.

FIP200 is required for maintenance and differentiation of postnatal neural stem cells

J. Guan, Chenran Wang, Yuan Zhu, 2013, Nature Neuroscience.

EphB1 Associates with Grb7 and Regulates Cell Migration*

J. Guan, D. Han, H. Miao, 2002, The Journal of Biological Chemistry.

PYK2 Is Involved in Premalignant Acinar Cell Reprogramming and Pancreatic Ductal Adenocarcinoma Maintenance by Phosphorylating β-CateninY654

J. Guan, Jing Hu, E. Chu, 2019, Cellular and molecular gastroenterology and hepatology.

Transformation andpp6Ov-src Autophosphorylation Correlate withSHC-GRB2Complex Formation inRat andChicken Cells Expressing Host-Range andKinase- active, Transformation-defective Alleles ofv-src

J. Guan, 1995 .

Biglycan Promotes Cancer Stem Cell Properties, NFκB Signaling and Metastatic Potential in Breast Cancer Cells

J. Guan, Michael A. Haas, S. Yeo, 2022, Cancers.

Function of Focal Adhesion Kinase Scaffolding to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activities in Vivo*

J. Guan, Shaogang Sun, Ming Luo, 2012, The Journal of Biological Chemistry.

Integrin signaling through FAK in the regulation of mammary stem cells and breast cancer

J. Guan, 2010, IUBMB life.

Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction

J. Guan, Jun-Lin Guan, Lee Ann Cooper, 2003, Molecular and Cellular Biology.

FIP200, a key signaling node to coordinately regulate various cellular processes.

J. Guan, B. Gan, 2008, Cellular signalling.

Grb7 in intracellular signaling and its role in cell regulation.

J. Guan, Tang-Long Shen, 2004, Frontiers in bioscience : a journal and virtual library.

Signal transduction in cell-matrix interactions.

J. Guan, H. Chen, Jun-Lin Guan, 1996, International review of cytology.

Autophagy blockade limits HER2+ breast cancer tumorigenesis by perturbing HER2 trafficking and promoting release via small extracellular vesicles.

J. Guan, S. Yeo, Xiaoting Zhang, 2021, Developmental Cell.

Improved efficacy of mitochondrial disrupting agents upon inhibition of autophagy in a mouse model of BRCA1-deficient breast cancer

J. Guan, Chenran Wang, Michael A. Haas, 2018, Autophagy.

Hierarchical heterogeneity in mammary tumors and its regulation by autophagy

J. Guan, S. Yeo, 2016, Autophagy.

Role of focal adhesion kinase in integrin signaling.

J. Guan, Jun-Lin Guan, J. Guan, 1997, The international journal of biochemistry & cell biology.

Transient inhibition of the ERK pathway prevents cerebellar developmental defects and improves long-term motor functions in murine models of neurofibromatosis type 1

Y. Wang, J. Guan, Chenran Wang, 2014, eLife.

Autophagic adaptation to oxidative stress alters peritoneal residential macrophage survival and ovarian cancer metastasis

J. Liu, J. Guan, W. Zou, 2020, JCI insight.

Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice.

H. Ueda, J. Guan, Xu Peng, 2004, Cardiovascular research.

Downregulation of FIP200 Induces Apoptosis of Glioblastoma Cells and Microvascular Endothelial Cells by Enhancing Pyk2 Activity

R. Weil, Ping Huang, R. Prayson, 2011, PloS one.

FAK Promotes Early Osteoprogenitor Cell Proliferation by Enhancing mTORC1 Signaling

Li Wang, J. Guan, Han Kyoung Choi, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Visualizing and Manipulating Focal Adhesion Kinase Regulation in Live Cells*

Sivaraj Sivaramakrishnan, J. Guan, Michael Ritt, 2013, The Journal of Biological Chemistry.

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

Ann Y Park, J. Guan, Shaogang Sun, 2010, The Journal of cell biology.

Focal adhesion kinase: protein interactions and cellular functions.

J. Guan, S. Abbi, 2002, Histology and histopathology.

Functional cooperation between co-amplified genes promotes aggressive phenotypes of HER2-positive breast cancer

J. Guan, S. Yeo, Xiaoting Zhang, 2021, Cell reports.

Suppression of Autophagy by FIP200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents

J. Guan, Heekyong R. Bae, 2011, Molecular Cancer Research.

DNA Damage and Cellular Stress Responses Suppression of Autophagy by FIP 200 Deletion Impairs DNA Damage Repair and Increases Cell Death upon Treatments with Anticancer Agents

J. Guan, Heekyong R. Bae, 2011 .

VEGF-induced vascular permeability is mediated by FAK.

J. Guan, S. Lim, D. Schlaepfer, 2012, Developmental cell.

miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/β-Catenin Axis

Zuoren Yu, J. Guan, Z. Shao, 2018, Theranostics.

miR-200 c / 141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK 1 / β-Catenin Axis

Zuoren Yu, J. Guan, Z. Shao, 2018 .

Nck-2 interacts with focal adhesion kinase and modulates cell motility.

J. Guan, Yun Hua, Y. Tu, 2002, International Journal of Biochemistry and Cell Biology.

Cool-1 functions as an essential regulatory node for EGFreceptor- and Src-mediated cell growth

Dan Baird, J. Guan, Xu Peng, 2006, Nature Cell Biology.

Snail1 controls epithelial–mesenchymal lineage commitment in focal adhesion kinase–null embryonic cells

S. Weiss, Ann Y Park, J. Guan, 2011, The Journal of cell biology.

TYROSINE PHOSPHORYLATION OF COFILIN AT Y68 BY V-SRC LEADS TO ITS DEGRADATION THROUGH UBIQUITIN-PROTEASOME PATHWAY

J. Guan, Chenran Wang, Y. Yoo, 2009, Oncogene.

Mechanisms of focal adhesion kinase regulation.

J. Guan, Lee Ann Cohen, 2005, Current cancer drug targets.

Mechanism of cell cycle regulation by FIP200 in human breast cancer cells.

J. Guan, B. Gan, Xu Peng, 2005, Cancer research.

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

R. Flavell, Ann Y Park, J. Guan, 2005, The Journal of cell biology.

Conversion of a secretory protein into a transmembrane protein results in its transport to the golgi complex but not to the cell surface

J. Guan, J. Rose, 1984, Cell.

Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore.

Zhiqi Tian, Jiajie Diao, Hui Chao, 2018, Small.

Super-Resolution Tracking of Mitochondrial Dynamics with An Iridium(III) Luminophore

J. Guan, Chenran Wang, Ruilin Guan, 2018, bioRxiv.

Stimulation of phosphatidylinositol 3'-kinase association with foca adhesion kinase by platelet-derived growth factor.

J. Guan, H. Chen, 1994, The Journal of biological chemistry.

Identification of a novel interaction between integrin β1 and 14-3-3β

J. Guan, D. Han, L. G. Rodríguez, 2001, Oncogene.

Autophagy gene FIP200 in neural progenitors non–cell autonomously controls differentiation by regulating microglia

J. Guan, Chenran Wang, Michael A. Haas, 2017, The Journal of cell biology.

Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionally

Zhike Lu, Chuan He, Juan Du, 2019, Nature.

Osteopontin mediates tumorigenic transformation of a preneoplastic murine cell line by suppressing anoikis: An Arg‐Gly‐Asp‐dependent‐focal adhesion kinase‐caspase‐8 axis

J. Guan, E. Oh, Y. Hsieh, 2015, Molecular carcinogenesis.

Distinct FAK activities determine progenitor and mammary stem cell characteristics.

M. Wicha, J. Guan, Song Chen, 2013, Cancer research.

Mammary epithelial-specific ablation of the focal adhesion kinase suppresses mammary tumorigenesis by affecting mammary cancer stem/progenitor cells.

M. Wicha, J. Guan, Chenran Wang, 2009, Cancer research.

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

Luke A. Torre-Healy, B. Calhoun, J. Guan, 2018, Nature Communications.

HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling

J. Guan, E. Lower, R. Karns, 2017, Oncotarget.

Activation of the Cdc42-associated Tyrosine Kinase-2 (ACK-2) by Cell Adhesion via Integrin β1 *

J. Guan, R. Cerione, Wannian Yang, 1999, The Journal of Biological Chemistry.

Interaction of N-WASP with hnRNPK and Its Role in Filopodia Formation and Cell Spreading*

J. Guan, Rong Li, Y. Yoo, 2006, Journal of Biological Chemistry.

Stimulation of cell migration by overexpression of focal adhesion kinase and its association with Src and Fyn.

J. Guan, L. Cary, J. Chang, 1996, Journal of cell science.

Integrin-Mediated Fibroblast Adhesion Strength: Role of the β1 Subunit

D. Hammer, J. Guan, K. Ward, 1993 .

Focal adhesion kinase: from in vitro studies to functional analyses in vivo.

J. Guan, Xu Peng, 2011, Current protein & peptide science.

Targeted therapy for mTORC1-driven tumours through HDAC inhibition by exploiting innate vulnerability of mTORC1 hyper-activation

J. Guan, Chenran Wang, Michael A. Haas, 2020, British Journal of Cancer.

Activation of FAK and Src are receptor-proximal events required for netrin signaling

Kyonsoo Hong, Seung-Hee Lee, Y. Rao, 2004, Nature Neuroscience.

Author Correction: Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation

Hailing Shi, Chuan He, Jianjun Chen, 2018, Nature Cell Biology.

Nuclear FAK and its kinase activity regulate VEGFR2 transcription in angiogenesis of adult mice

J. Guan, Shaogang Sun, Hsin-jung Wu, 2018, Scientific Reports.

Integrins, Rafts, Rac, and Rho

J. Guan, 2004, Science.

Inhibition of autophagy mitigates cell migration and invasion in thyroid cancer.

J. Guan, Tammy M. Holm, Kanakaraju Manupati, 2021, Surgery.

Cell migration : developmental methods and protocols

J. Guan, Jun-Lin Guan, 2005 .

HGFL-mediated RON signaling supports breast cancer stem cell phenotypes via activation of non-canonical β-catenin signaling

J. Guan, E. Lower, R. Karns, 2017, Oncotarget.

A Tyrosine-phosphorylated Protein That Binds to an Important Regulatory Region on the Cool Family of p21-activated Kinase-binding Proteins*

J. Guan, R. Premont, S. Bagrodia, 1999, The Journal of Biological Chemistry.

Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage

A. Jegga, J. Guan, Kai Huang, 2020, Redox biology.

Non-canonical function of FIP200 is required for neural stem cell maintenance and differentiation by limiting TBK1 activation and p62 aggregate formation

J. Guan, Chenran Wang, Michael A. Haas, 2021, Scientific Reports.

Prefused lysosomes cluster on autophagosomes regulated by VAMP8

R. Pfuetzner, A. Brunger, J. Guan, 2020, Cell Death & Disease.

Selective Autophagy of Mitochondria on a Ubiquitin-Endoplasmic-Reticulum Platform

J. Guan, H. Vihinen, E. Jokitalo, 2019, Developmental cell.

Deletion of Cdc42 Enhances ADAM17-Mediated Vascular Endothelial Growth Factor Receptor 2 Shedding and Impairs Vascular Endothelial Cell Survival and Vasculogenesis

Shenyuan L. Zhang, J. Guan, Yixin Jin, 2013, Molecular and Cellular Biology.

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

Shaoying Lu, Jihye Seong, Jie Sun, 2013, Proceedings of the National Academy of Sciences.

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells

Shu Chien, S. Usami, S. Chien, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Selective MAP1LC3C (LC3C) autophagy requires noncanonical regulators and the C-terminal peptide

N. Talbot, J. Guan, D. Plas, 2021, The Journal of cell biology.

Selective MAP1LC3C (LC3C) autophagy requires noncanonical initiation regulators and the paralog-specific C-terminal peptide

N. Talbot, J. Guan, D. Plas, 2021, bioRxiv.

The autophagy-inducing kinases, ULK1 and ULK2, regulate axon guidance in the developing mouse forebrain via a noncanonical pathway

D. Green, J. Guan, Mao Yang, 2018, Autophagy.

Spatial Interplay between PIASy and FIP200 in the Regulation of Signal Transduction and Transcriptional Activity

A. Dejean, H. Urlaub, J. Guan, 2008, Molecular and Cellular Biology.

To move or not: how a cell responds (Review).

J. Guan, R. Christopher, 2000, International journal of molecular medicine.

Drosophila Fip200 is an essential regulator of autophagy that attenuates both growth and aging

John Calvin Reed, Myungjin Kim, J. Guan, 2013, Autophagy.

Enhanced autophagy in Becn1F121A/F121A knockin mice counteracts aging-related neural stem cell exhaustion and dysfunction

J. Guan, Chenran Wang, Michael A. Haas, 2021, Autophagy.

Autophagy promotes growth of tumors with high mutational burden by inhibiting a T-cell immune response

Chang S. Chan, E. White, J. Rabinowitz, 2020, Nature Cancer.

Differential stimulation of proline-rich tyrosine kinase 2 and mitogen-activated protein kinase by sphingosine 1-phosphate.

J. Guan, C. Zheng, I. Martìn‐padura, 1998, European journal of biochemistry.

Autophagy inhibition prevents lymphatic malformation progression to lymphangiosarcoma by decreasing osteopontin and Stat3 signaling

J. Guan, Fuchun Yang, Shaogang Sun, 2023, Nature Communications.

Erratum to: Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice

J. Guan, Yixin Jin, Xu Peng, 2013, Protein & Cell.

Inactivation of focal adhesion kinase in cardiomyocytes promotes eccentric cardiac hypertrophy and fibrosis in mice.

J. Guan, K. Chien, Guangju Ji, 2005, The Journal of clinical investigation.

Heterogeneity Within Molecular Subtypes of Breast Cancer.

J. Guan, S. Yeo, Tammy M. Holm, 2021, American journal of physiology. Cell physiology.

An autophagy-independent role for LC3 in equine arteritis virus replication

J. Guan, P. Rottier, Iryna Monastyrska, 2013, Autophagy.

Cx26 drives self-renewal in triple-negative breast cancer via interaction with NANOG and focal adhesion kinase

Ofer Reizes, Luke A. Torre-Healy, B. Calhoun, 2018, Nature Communications.

Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules.

J. Guan, Daniel S Rhoads, Jun-Lin Guan, 2007, Experimental cell research.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

FAK activates AKT-mTOR signaling to promote the growth and progression of MMTV-Wnt1-driven basal-like mammary tumors

J. Guan, S. Yeo, Ming Luo, 2020, Breast Cancer Research.

Regulation of Integrin β1 Recycling to Lipid Rafts by Rab1a to Promote Cell Migration*

K. Guan, J. Guan, Eunjung Kim, 2010, The Journal of Biological Chemistry.

Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression.

B. Chen, S. Chien, J. Guan, 2003, Molecular cell.

FAK–MAPK‐dependent adhesion disassembly downstream of L1 contributes to semaphorin3A‐induced collapse

M. Tessier-Lavigne, A. Yaron, J. Guan, 2008, The EMBO journal.

Advanced imaging techniques for tracking drug dynamics at the subcellular level.

R. Chen, J. Guan, Kangqiang Qiu, 2023, Advanced drug delivery reviews.

Inactivation of Cdc42 in embryonic brain results in hydrocephalus with ependymal cell defects in mice

J. Guan, Yixin Jin, Xu Peng, 2013, Protein & Cell.

Activation of Endogenous FAK via Expression of Its Amino Terminal Domain in Xenopus Embryos

J. Guan, Daniel S Rhoads, P. Skourides, 2012, PloS one.

The Nonreceptor Tyrosine Kinase ACK2, a Specific Target for Cdc42 and a Negative Regulator of Cell Growth and Focal Adhesion Complexes*

J. Guan, R. Cerione, Wannian Yang, 2001, The Journal of Biological Chemistry.

Neural Crest‐Specific TSC1 Deletion in Mice Leads to Sclerotic Craniofacial Bone Lesion

Li Wang, M. Giovannini, J. Guan, 2015, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Autophagy inhibition perturbs ERBB2 trafficking and abolishes tumorigenesis in ERBB2-driven breast cancer

J. Guan, S. Yeo, M. Hao, 2021, Autophagy.

Abstract 4386: Regulation of FIP200 by Her2 and its role in Her2-driven mammary tumors

J. Guan, Ming Hao, 2018, Molecular and Cellular Biology / Genetics.

A membrane-anchored form but not the secretory form of human chorionic gonadotropin-alpha chain acquires polylactosaminoglycan.

J. Guan, J. Rose, M. Fukuda, 1988, The Journal of biological chemistry.

Cell-surface expression of a membrane-anchored form of the human chorionic gonadotropin alpha subunit.

J. Guan, J. Rose, H. Cao, 1988, The Journal of biological chemistry.

FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells.

S. Morrison, J. Guan, Fei Liu, 2010, Blood.

CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.

D. Birnbaum, G. Dontu, M. Wicha, 2010, The Journal of clinical investigation.