C. Bouzat

发表

Mutation of the acetylcholine receptor α subunit causes a slow-channel myasthenic syndrome by enhancing agonist binding affinity

K. Ohno, A. Auerbach, S. Sine, 1995, Neuron.

Structural Basis of Activation of Cys-Loop Receptors: the Extracellular–Transmembrane Interface as a Coupling Region

C. Bouzat, Mariana Bartos, Jeremías Corradi, 2009, Molecular Neurobiology.

Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel

Steven M. Sine, Palmer Taylor, P. Taylor, 2004, Nature.

New insights into the structural bases of activation of Cys-loop receptors

C. Bouzat, 2012, Journal of Physiology-Paris.

Myogenic differentiation of the muscle clonal cell line BC3H-1 is accompanied by changes in its lipid composition

F. Barrantes, C. Bouzat, L. Politi, 1992, Lipids.

An intrinsic GABAergic system in human lymphocytes

C. Bouzat, L. Dionisio, M. J. D. Rosa, 2011, Neuropharmacology.

nAChR: nicotinic acetylcholine receptor ACh: acetylcholine pLGIC: pentameric ligand-gated ion channel Neo: neoflavonoid 5,7-dihydroxy-4-phenylcoumarin TMD: transmembrane domain ECD: extracellular domain Gen: genistein Que: quercetin 5-HI: 5-hydroxyindole PNU-120596: N-(5-Chloro-2,4-dimethoxyphenyl)-

C. Bouzat, I. Bermúdez, B. E. Nielsen, 2019 .

Flavonoids as positive allosteric modulators of α7 nicotinic receptors

C. Bouzat, I. Bermúdez, B. E. Nielsen, 2019, Neuropharmacology.

A Functional Interaction Between Y674-R685 Region of the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic Receptor

C. Bouzat, A. Mulholland, T. Gallagher, 2022, Molecular Neurobiology.

Loss of Choline Agonism in the Inner Ear Hair Cell Nicotinic Acetylcholine Receptor Linked to the α10 Subunit

C. Bouzat, M. Lipovsek, A. Elgoyhen, 2020, bioRxiv.

Corticosterone affects the differentiation of a neuronal cerebral cortex-derived cell line through modulation of the nicotinic acetylcholine receptor

F. Barrantes, C. Bouzat, C. J. Baier, 2014, Neuroscience.

Alpha 7 nicotinic acetylcholine receptor modulates lymphocyte activation.

C. Bouzat, E. Agriello, L. Dionisio, 2009, Life sciences.

A Conserved Arginine with Non-Conserved Function is a Key Determinant of Agonist Selectivity in Alpha7 Nicotinic Acetylcholine Receptors

R. Sessions, C. Bouzat, A. Mulholland, 2020, Biophysical Journal.

Molecular function of α7 nicotinic receptors as drug targets

C. Bouzat, M. C. Esandi, B. E. Nielsen, 2017, The Journal of physiology.

Molecular function of the novel α7β2 nicotinic receptor

C. Bouzat, I. Bermúdez, B. E. Nielsen, 2018, Cellular and Molecular Life Sciences.

Stoichiometry for activation of neuronal α7 nicotinic receptors

S. Sine, C. Bouzat, N. Andersen, 2013, Proceedings of the National Academy of Sciences.

Effects of long-chain fatty acids on the channel activity of the nicotinic acetylcholine receptor.

F. Barrantes, C. Bouzat, 1993, Receptors & channels.

Design, Synthesis and Functional Evaluation of a Novel Series of Phosphonate-functionalized 1,2,3-triazoles as Positive Allosteric Modulators of α7 Nicotinic Acetylcholine Receptors.

C. Bouzat, C. Vitale, B. E. Nielsen, 2020, ACS chemical neuroscience.

Molecular function of the novel α7β2 nicotinic receptor

C. Bouzat, I. Bermúdez, B. E. Nielsen, 2018, Cellular and Molecular Life Sciences.

Molecular mechanisms and binding site location for the noncompetitive antagonist crystal violet on nicotinic acetylcholine receptors.

J. Trudell, H. Arias, C. Bouzat, 2006, Biochemistry.

Iron(II) promoted direct synthesis of dibenzo[b,e]oxepin-11(6H)-one derivatives with biological activity. A short synthesis of doxepin

C. Bouzat, V. Martín, Jimena Scoccia, 2017 .

Changes in channel properties of acetylcholine receptors during the time course of thiol chemical modifications

F. Sigworth, F. Barrantes, C. Bouzat, 1991, Pflügers Archiv.

The nematode serotonin-gated chloride channel MOD-1: A novel target for anthelmintic therapy

C. Bouzat, J. Corradi, Noelia Rodriguez Araujo, 2022, The Journal of biological chemistry.

Tyrosine phosphorylation differentially fine-tunes ionotropic and metabotropic responses of human α7 nicotinic acetylcholine receptor

C. Bouzat, A. Bruzzone, M. C. Esandi, 2021, Cellular and Molecular Life Sciences.

Orthosteric and Allosteric Activation of Human 5-HT3A Receptors.

C. Bouzat, J. Corradi, C. Fabiani, 2020, Biophysical journal.

A New Antagonist of Caenorhabditis elegans Glutamate-Activated Chloride Channels With Anthelmintic Activity

C. Bouzat, D. Gerbino, M. B. Faraoni, 2020, Frontiers in Neuroscience.

Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity

C. Bouzat, Guillermina Hernando, Ornella Turani, 2019, PLoS neglected tropical diseases.

Exploring the positive allosteric modulation of human α7 nicotinic receptors from a single-channel perspective

H. Arias, C. Bouzat, D. Feuerbach, 2016, Neuropharmacology.

Unraveling Mechanisms Underlying Partial Agonism in 5-HT3A Receptors

C. Bouzat, J. Corradi, 2014, The Journal of Neuroscience.

Caenorhabditis elegans Neuromuscular Junction: GABA Receptors and Ivermectin Action

C. Bouzat, Guillermina Hernando, 2014, PloS one.

Contribution of Subunits to Caenorhabditis elegans Levamisole-Sensitive Nicotinic Receptor Function

C. Bouzat, D. Rayes, Guillermina Hernando, 2012, Molecular Pharmacology.

Single-channel kinetic analysis for activation and desensitization of homomeric 5-HT(3)A receptors.

C. Bouzat, J. Corradi, Fernanda Gumilar, 2009, Biophysical journal.

The Interface between Extracellular and Transmembrane Domains of Homomeric Cys-Loop Receptors Governs Open-Channel Lifetime and Rate of Desensitization

S. Sine, C. Bouzat, J. Corradi, 2008, The Journal of Neuroscience.

Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptor.

S. Sine, C. Bouzat, Fernanda Gumilar, 2002, Biophysical journal.

Low arsenic concentrations impair memory in rat offpring exposed during pregnancy and lactation: Role of &agr;7 nicotinic receptor, glutamate and oxidative stress

C. Bouzat, L. Giannuzzi, C. Gallegos, 2018, Neurotoxicology.

Molecular mechanisms and binding site locations for noncompetitive antagonists of nicotinic acetylcholine receptors.

H. Arias, C. Bouzat, Pankaj Bhumireddy, 2006, The international journal of biochemistry & cell biology.

Tricyclic antidepressants inhibit homomeric Cys-loop receptors by acting at different conformational states.

C. Bouzat, Fernanda Gumilar, 2008, European journal of pharmacology.

Nongenomic effects of steroids on the nicotinic acetylcholine receptor.

F. Barrantes, S. Antollini, C. Bouzat, 2000, Kidney international.

Structural basis of the different gating kinetics of fetal and adult acetylcholine receptors

S. Sine, C. Bouzat, N. Bren, 1994, Neuron.

5-HT3 Receptor Brain-Type B-Subunits are Differentially Expressed in Heterologous Systems

C. Bouzat, A. J. Thompson, K. Price, 2015, ACS chemical neuroscience.

Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells*

C. Bouzat, Nicolás I Torres, N. Zwirner, 2016, The Journal of Biological Chemistry.

Mechanism of calcium potentiation of the α7 nicotinic acetylcholine receptor

S. Sine, C. Bouzat, Kathiresan Natarajan, 2020, The Journal of general physiology.

Activation of Caenorhabditis elegans Levamisole-Sensitive and Mammalian Nicotinic Receptors by the Antiparasitic Bephenium

C. Bouzat, J. Corradi, Guillermina Hernando, 2018, Molecular Pharmacology.

A human-specific, truncated α7 nicotinic receptor subunit assembles with full-length α7 and forms functional receptors with different stoichiometries

C. Bouzat, A. Bruzzone, M. C. Esandi, 2018, The Journal of Biological Chemistry.

Neurotransmitter GABA Activates Muscle but Not α7 Nicotinic Receptors

C. Bouzat, L. Dionisio, M. C. Esandi, 2015, Molecular Pharmacology.

Single-Channel and Structural Foundations of Neuronal α7 Acetylcholine Receptor Potentiation

S. Sine, C. Bouzat, Corrie J. B. daCosta, 2011, The Journal of Neuroscience.

Stoichiometry of the α9α10 Nicotinic Cholinergic Receptor

C. Bouzat, A. Elgoyhen, P. Plazas, 2005, The Journal of Neuroscience.

Functional Relationships between Agonist Binding Sites and Coupling Regions of Homomeric Cys-Loop Receptors

S. Sine, C. Bouzat, N. Andersen, 2011, The Journal of Neuroscience.

Relationship between α7 nAChR and apoptosis in human lymphocytes

C. Bouzat, A. Garelli, D. Rayes, 2005, Journal of Neuroimmunology.

Relationship between alpha 7 nAChR and apoptosis in human lymphocytes.

C. Bouzat, A. Garelli, D. Rayes, 2005, Journal of neuroimmunology.

Alterations in the memory of rat offspring exposed to low levels of fluoride during gestation and lactation: Involvement of the α7 nicotinic receptor and oxidative stress.

C. Bouzat, L. Cancela, M. C. Esandi, 2018, Reproductive toxicology.

Diazepam treatment reduces inflammatory cells and mediators in the central nervous system of rats with experimental autoimmune encephalomyelitis

C. Bouzat, G. A. Roth, S. Zanetti, 2017, Journal of Neuroimmunology.

Number and Locations of Agonist Binding Sites Required to Activate Homomeric Cys-Loop Receptors

S. Sine, C. Bouzat, D. Rayes, 2009, The Journal of Neuroscience.

Understanding the Bases of Function and Modulation of α7 Nicotinic Receptors: Implications for Drug Discovery

C. Bouzat, Cecilia Bouzat, Jeremías Corradi, 2016, Molecular Pharmacology.

The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms

J. Dilger, C. Bouzat, G. Spitzmaul, 2009, British journal of pharmacology.

A Functional Interaction Between the SARS-CoV-2 Spike Protein and the Human α7 Nicotinic Receptor

C. Bouzat, A. Mulholland, T. Gallagher, 2021 .

A conserved arginine with non‐conserved function is a key determinant of agonist selectivity in α7 nicotinic ACh receptors

R. Sessions, C. Bouzat, A. Mulholland, 2021, British journal of pharmacology.

Molecular Modulation of Human α7 Nicotinic Receptor by Amyloid-β Peptides

S. Antollini, C. Bouzat, Matías Lasala, 2019, Front. Cell. Neurosci..

The nicotinic acetylcholine receptor as a molecular machine for neuromuscular transmission

C. Bouzat, N. Mukhtasimova, 2018, Current Opinion in Physiology.

Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.

H. Arias, C. Bouzat, R. Moaddel, 2009, Biochemistry.

Mechanistic contributions of residues in the M1 transmembrane domain of the nicotinic receptor to channel gating

C. Bouzat, G. Spitzmaul, J. Corradi, 2004, Molecular membrane biology.

Inherited and experimentally induced changes in gating kinetics of muscle nicotinic acetylcholine receptor

F. Barrantes, C. Bouzat, 1999, Journal of Molecular Neuroscience.

Assigning functions to residues in the acetylcholine receptor channel region (review).

F. Barrantes, C. Bouzat, Francisco J. Barrantes, 1997, Molecular membrane biology.

Modulation of Muscle Nicotinic Acetylcholine Receptors by the Glucocorticoid Hydrocortisone

F. Barrantes, C. Bouzat, 1996, The Journal of Biological Chemistry.

New mutations in acetylcholine receptor subunit genes reveal heterogeneity in the slow-channel congenital myasthenic syndrome.

K. Ohno, S. Sine, C. Bouzat, 1996, Human molecular genetics.

An ER‐resident membrane protein complex regulates nicotinic acetylcholine receptor subunit composition at the synapse

H. Hutter, J. Liewald, A. Gottschalk, 2009, The EMBO journal.

Activation and modulation of the nicotinic receptor

H. Arias, C. Bouzat, 2010, Journal of Pediatric Biochemistry.

Congenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunit.

K. Ohno, S. Sine, C. Bouzat, 1995, Proceedings of the National Academy of Sciences of the United States of America.

End‐plate acetylcholine receptor deficiency due to nonsense mutations in the ε subunit

R. Griggs, K. Ohno, S. Sine, 1996 .

Differential Contribution of Subunit Interfaces to α9α10 Nicotinic Acetylcholine Receptor Function

C. Bouzat, N. Millar, JasKiran K. Gill-Thind, 2017, Molecular Pharmacology.

Differential pharmacological activity of JN403 between α7 and muscle nicotinic acetylcholine receptors.

H. Arias, C. Bouzat, D. Feuerbach, 2013, Biochemistry.

Heterologous retinal cultured neurons and cell adhesion molecules induce clustering of acetylcholine receptors and polynucleation in mouse muscle BC3H‐1 clonal cell line

F. Barrantes, C. Bouzat, L. Politi, 1996, Journal of neuroscience research.

End-plate acetylcholine receptor deficiency due to nonsense mutations in the epsilon subunit.

R. Griggs, K. Ohno, S. Sine, 1996, Annals of neurology.

Molecular mechanisms of inhibition of nicotinic acetylcholine receptors by tricyclic antidepressants

H. Arias, C. Bouzat, G. Spitzmaul, 2003, Neuropharmacology.

Nicotinic Receptor Fourth Transmembrane Domain: Hydrogen Bonding by Conserved Threonine Contributes to Channel Gating Kinetics

F. Barrantes, S. Sine, C. Bouzat, 2000 .

Nicotinic acetylcholine receptors at the single‐channel level

S. Sine, C. Bouzat, Steven M Sine, 2018, British journal of pharmacology.

A Cys-loop Mutation in the Caenorhabditis elegans Nicotinic Receptor Subunit UNC-63 Impairs but Does Not Abolish Channel Function*

Andrew K. Jones, S. Buckingham, D. Sattelle, 2010, The Journal of Biological Chemistry.

Subunit-selective role of the M3 transmembrane domain of the nicotinic acetylcholine receptor in channel gating.

C. Bouzat, M. J. De Rosa, J. Corradi, 2008, Biochimica et biophysica acta.

Key roles of hydrophobic rings of TM2 in gating of the α9α10 nicotinic cholinergic receptor

C. Bouzat, M. Verbitsky, N. Weisstaub, 2005 .

Regulation of nicotinic acetylcholine receptors by post-translational modifications.

C. Bouzat, Juan Facundo Chrestia, Guillermina Hernando, 2023, Pharmacological research.

Hydrocortisone and 11-desoxycortisone modify acetylcholine receptor channel gating.

F. Barrantes, C. Bouzat, 1993, Neuroreport.

Acetylcholine receptor channel properties are modified by benzyl alcohol.

F. Barrantes, C. Bouzat, 1991, Neuroreport.

GABAA receptor plasticity in Jurkat T cells.

C. Bouzat, L. Dionisio, M. C. Esandi, 2013, Biochimie.

A novel mechanism of modulation of 5-HT₃A receptors by hydrocortisone.

C. Bouzat, N. Andersen, J. Corradi, 2011, Biophysical journal.

Role of pairwise interactions between M1 and M2 domains of the nicotinic receptor in channel gating.

C. Bouzat, M. Costabel, G. Spitzmaul, 2007, Biophysical journal.

Nicotinic receptor M3 transmembrane domain: position 8' contributes to channel gating.

C. Bouzat, G. Spitzmaul, D. Rayes, 2002, Molecular pharmacology.

Nicotinic Receptor Fourth Transmembrane Domain

F. Barrantes, S. Sine, C. Bouzat, 2000, The Journal of general physiology.

The noncompetitive inhibitor quinacrine modifies the desensitization kinetics of muscle acetylcholine receptors.

J. Dilger, C. Bouzat, G. Spitzmaul, 2001, Molecular pharmacology.

Ephedrine blocks wild‐type and long‐lived mutant acetylcholine receptor channels

C. Bouzat, 1996, Neuroreport.

Molecular Basis of the Differential Sensitivity of Nematode and Mammalian Muscle to the Anthelmintic Agent Levamisole*

C. Bouzat, D. Rayes, M. J. De Rosa, 2004, Journal of Biological Chemistry.

Mutations at lipid-exposed residues of the acetylcholine receptor affect its gating kinetics.

F. Barrantes, C. Bouzat, A. M. Roccamo, 1998, Molecular pharmacology.

Single-Channel Kinetic Analysis of Chimeric α7–5HT3A Receptors

S. Sine, C. Bouzat, G. Spitzmaul, 2005, Molecular Pharmacology.

Effects of static magnetic fields on nicotinic cholinergic receptor function

Walter Rubén Cravero, C. Bouzat, W. Cravero, 2011, Bioelectromagnetics.

Steroids differentially inhibit the nicotinic acetylcholine receptor

F. Barrantes, C. Bouzat, I. Garbus, 2001, Neuroreport.

Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator.

P. Biggin, C. Bouzat, Franco Viscarra, 2023, ACS chemical neuroscience.

The diverse family of Cys-loop receptors in Caenorhabditis elegans: insights from electrophysiological studies

C. Bouzat, Noelia Rodriguez Araujo, Guillermina Hernando, 2023, Biophysical Reviews.

The anthelmintic pyrantel acts as a low efficacious agonist and an open-channel blocker of mammalian acetylcholine receptors

C. Bouzat, G. Spitzmaul, D. Rayes, 2001, Neuropharmacology.

New Multitarget Molecules Derived from Caffeine as Potentiators of the Cholinergic System.

S. Antollini, C. Bouzat, M. Costabel, 2024, ACS chemical neuroscience.

Key roles of hydrophobic rings of TM2 in gating of the alpha9alpha10 nicotinic cholinergic receptor.

C. Bouzat, M. Verbitsky, N. Weisstaub, 2005, British journal of pharmacology.

Activation of Single Nicotinic Receptor Channels from Caenorhabditis elegans Muscle

C. Bouzat, M. Flamini, D. Rayes, 2007, Molecular Pharmacology.