Satish K. Dhingra

发表

Structure and Drug Resistance of the Plasmodium falciparum Transporter PfCRT

Yong Zi Tan, P. Roepe, D. Fidock, 2019, Nature.

Structure and Drug Resistance of the Plasmodium Falciparum Transporter PfCRT

Bridget Carragher, Clinton S. Potter, David A. Fidock, 2020 .

Preclinical Antimalarial Combination Studies: The Case of M5717, a P. falciparum 1 Elongation Factor 2 Inhibitor and Pyronaridine, a Hemozoin Formation Inhibitor

D. Fidock, Satish K. Dhingra, B. Jonat, 2020 .

Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor

D. Fidock, Satish K. Dhingra, B. Jonat, 2020, Antimicrobial Agents and Chemotherapy.

Evolution of Fitness Cost-Neutral Mutant PfCRT Conferring P. falciparum 4-Aminoquinoline Drug Resistance Is Accompanied by Altered Parasite Metabolism and Digestive Vacuole Physiology

M. Llinás, T. Egan, Jill M Combrinck, 2016, PLoS pathogens.

A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine

E. Winzeler, T. Egan, Jill M Combrinck, 2017, mBio.

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

S. Dalal, M. Llinás, M. Klemba, 2018, Scientific Reports.

Evidence for the early emergence of piperaquine-resistant Plasmodium falciparum malaria and modeling strategies to mitigate resistance

M. Eppstein, P. Roepe, D. Fidock, 2022, PLoS pathogens.

Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter

G. Johnston, Adele M. Lehane, D. Fidock, 2015, Molecular microbiology.

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

D. Fidock, L. Ross, Satish K. Dhingra, 2018, Nature Communications.

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

D. Fidock, Satish K. Dhingra, Jennifer Small-Saunders, 2019, mBio.

Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies

Adele M. Lehane, Rowena E. Martin, D. Fidock, 2016, Nature Communications.

Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt

D. Wirth, D. Fidock, S. Volkman, 2015, Proceedings of the National Academy of Sciences.

P. falciparum K13 mutations present varying degrees of artemisinin resistance and reduced fitness in African parasites

P. Rosenthal, D. Fidock, L. Ross, 2021, bioRxiv.

Plasmodium falciparum K13 mutations in Africa and Asia impact artemisinin resistance and parasite fitness

D. Fidock, L. Ross, F. Nosten, 2021, eLife.

Plasmodium falciparum K13 mutations in Africa and Asia present varying degrees of artemisinin resistance and an elevated fitness cost in African parasites

P. Rosenthal, D. Fidock, L. Ross, 2021, bioRxiv.

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

D. Fidock, L. Ross, P. Sinnis, 2023, bioRxiv.

Plasmodium falciparum resistance to piperaquine driven by PfCRT.

D. Fidock, Satish K. Dhingra, D. Ménard, 2019, The Lancet. Infectious diseases.

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.

Pradipsinh K Rathod, Xiaoyi Deng, P. Rathod, 2018, ACS infectious diseases.

Integrative Genetic Manipulation of Plasmodium cynomolgi Reveals Multidrug Resistance-1 Y976F Associated With Increased In Vitro Susceptibility to Mefloquine

D. Kyle, D. Fidock, L. Rénia, 2022, The Journal of infectious diseases.

Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study

J. McCarthy, D. Fidock, Akash Khandelwal, 2021, The Lancet. Infectious diseases.

Single-Particle Cryo-EM Structure of Plasmodium falciparum Chloroquine Resistance Transporter (PfCRT) 7G8 Isoform

Yong Zi Tan, P. Roepe, D. Fidock, 2019 .

Causal chemoprophylactic activity of cabamiquine against Plasmodium falciparum in a controlled human malaria infection: a randomised, double-blind, placebo-controlled study in the Netherlands.

D. Fidock, Akash Khandelwal, Satish K. Dhingra, 2023, Lancet. Infectious Diseases (Print).

Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter

G. Johnston, Adele M. Lehane, D. Fidock, 2015, Molecular microbiology.

Mapping the genomic landscape of multidrug resistance in Plasmodium falciparum and its impact on parasite fitness

D. Fidock, P. Sinnis, Jonathan Kim, 2023, Science advances.