Amy D. Fung

发表

Structure of the Respiratory Syncytial Virus Polymerase Complex

J. McLellan, Morgan S. A. Gilman, C. Liu, 2019, Cell.

Small-molecule inhibition of TNF-alpha.

A. Whitty, J. Eldredge, Amy D. Fung, 2005, Science.

Small-Molecule Inhibition of TNF-α

Jun Wang, Adrian Whitty, Alexey Lugovskoy, 2005, Science.

Discovery of an Aurora kinase inhibitor through site-specific dynamic combinatorial chemistry.

Daniel A Erlanson, Amy D. Fung, D. Erlanson, 2008, Bioorganic & medicinal chemistry letters.

Discovery of N-[4-[6-tert-butyl-5-methoxy-8-(6-methoxy-2-oxo-1H-pyridin-3-yl)-3-quinolyl]phenyl]methanesulfonamide (RG7109), a potent inhibitor of the hepatitis C virus NS5B polymerase.

D. Davis, A. Railkar, Amy D. Fung, 2014, Journal of medicinal chemistry.

Discovery of a novel series of potent non-nucleoside inhibitors of hepatitis C virus NS5B.

Amy D. Fung, S. Harris, S. Le Pogam, 2013, Journal of medicinal chemistry.

2-Aminobenzimidazoles as potent Aurora kinase inhibitors.

Amy D. Fung, T. O'Brien, W. Flanagan, 2009, Bioorganic & medicinal chemistry letters.

Water-soluble prodrugs of an Aurora kinase inhibitor.

Amy D. Fung, R. Mcdowell, J. Jacobs, 2009, Bioorganic & medicinal chemistry letters.

951 SILIBININ INHIBITS HCV REPLICATION IN VITRO

Amy D. Fung, P. Ferenci, N. Cammack, 2009 .

Discovery of 4'-chloromethyl-2'-deoxy-3',5'-di-O-isobutyryl-2'-fluorocytidine (ALS-8176), a first-in-class RSV polymerase inhibitor for treatment of human respiratory syncytial virus infection.

Amy D. Fung, Zhinan Jin, Qingling Zhang, 2015, Journal of medicinal chemistry.

Efficiency of Incorporation and Chain Termination Determines the Inhibition Potency of 2′-Modified Nucleotide Analogs against Hepatitis C Virus Polymerase

Amy D. Fung, Zhinan Jin, J. Deval, 2014, Antimicrobial Agents and Chemotherapy.

Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.

Amy D. Fung, Zhinan Jin, J. Deval, 2020, Journal of medicinal chemistry.

Synthesis and Anti-HCV Activities of 4'-Fluoro-2'-Substituted Uridine Triphosphates and Nucleotide Prodrugs: Discovery of 4'-Fluoro-2'- C-methyluridine 5'-Phosphoramidate Prodrug (AL-335) for the Treatment of Hepatitis C Infection.

Amy D. Fung, Zhinan Jin, Qingling Zhang, 2019, Journal of medicinal chemistry.

Molecular Basis for the Selective Inhibition of Respiratory Syncytial Virus RNA Polymerase by 2'-Fluoro-4'-Chloromethyl-Cytidine Triphosphate

Amy D. Fung, Zhinan Jin, Qingling Zhang, 2015, PLoS pathogens.

Biochemical Effect of Resistance Mutations against Synergistic Inhibitors of RSV RNA Polymerase

Amy D. Fung, Paul C Jordan, Jiazi Meng, 2016, PloS one.

Discovery of a potent and selective aurora kinase inhibitor.

Wang Shen, Amy D. Fung, Joni W. Lam, 2008, Bioorganic & medicinal chemistry letters.

A Conserved Domain of Schizosaccharomyces pombe dfp1+ Is Uniquely Required for Chromosome Stability following Alkylation Damage during S Phase

Grant W. Brown, J. Ou, Amy D. Fung, 2002, Molecular and Cellular Biology.

Small molecule inhibition of the TNF family cytokine CD40 ligand through a subunit fracture mechanism.

Fang Qian, Adrian Whitty, Lihong Sun, 2011, ACS chemical biology.

Cyclic amide bioisosterism: strategic application to the design and synthesis of HCV NS5B polymerase inhibitors.

Amy D. Fung, N. Arora, S. Harris, 2010, Bioorganic & medicinal chemistry letters.