Jun Chen

发表

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.

Hui Xu, Tianbo Li, A. Rohou, 2019 .

TRPA1 modulation by piperidine carboxamides suggests an evolutionarily conserved binding site and gating mechanism

M. Klein, M. Volgraf, V. Carnevale, 2019, Proceedings of the National Academy of Sciences.

Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions

J. DeVoss, S. Warming, Tianbo Li, 2017, Nature Communications.

Mechanism of methanesulfonanilide block of the HERG potassium channel

Jun Chen, S. John, C. Michael, 2000 .

An impedance-based cell contraction assay using human primary smooth muscle cells and fibroblasts.

Jun Chen, T. Chernov-Rogan, Daniel D. Bravo, 2018, Journal of pharmacological and toxicological methods.

A Retrospective Look at the Impact of Binding Site Environment on the Optimization of TRPA1 Antagonists.

M. Volgraf, Jun Chen, S. Shields, 2021, ACS medicinal chemistry letters.

Voltage-Gated Sodium Channels in Drug Discovery

Tianbo Li, Jun Chen, 2018, Ion Channels in Health and Sickness.

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Alexis Rohou, Christopher P. Arthur, Jun Chen, 2019, Cell.

Cryo-EM reveals an unprecedented binding site for NaV1.7 inhibitors enabling rational design of potent hybrid inhibitors

M. Volgraf, A. Rohou, C. Arthur, 2022, bioRxiv.

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain.

D. Sutherlin, Jun Chen, D. Hackos, 2019, Journal of medicinal chemistry.

Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin

Hui Xu, Tianbo Li, A. Rohou, 2019, Cell.

TRPA1 as a drug target—promise and challenges

Jun Chen, D. Hackos, 2015, Naunyn-Schmiedeberg's Archives of Pharmacology.

A Non-covalent Ligand Reveals Biased Agonism of the TRPA1 Ion Channel

M. Volgraf, Tianbo Li, A. Rohou, 2020, Neuron.

Tetrahydrofuran-Based Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonists: Ligand-Based Discovery, Activity in a Rodent Asthma Model, and Mechanism-of-Action via Cryogenic Electron Microscopy.

M. Volgraf, A. Rohou, Jun Chen, 2021, Journal of medicinal chemistry.

High-throughput electrophysiological assays for voltage gated ion channels using SyncroPatch 768PE

Tianbo Li, Jun Chen, Gang Lu, 2017, PloS one.

The GluN2B subunit represents a major functional determinant of NMDA receptors in human induced pluripotent stem cell-derived cortical neurons.

Jun Chen, Yanmei Lu, M. Alaoui-Ismaili, 2018, Stem cell research.

Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310.

D. Sutherlin, Jun Chen, D. Hackos, 2021, Journal of medicinal chemistry.

A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment

Simon S. Gao, J. Elstrott, M. Volgraf, 2021, The Journal of experimental medicine.

Discovery of a Potent (4 R,5 S)-4-Fluoro-5-methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 Antagonist and Its Methylene Phosphate Prodrug Guided by Molecular Modeling.

C. Brotherton-Pleiss, M. Volgraf, Jun Chen, 2018, Journal of medicinal chemistry.

α-Aryl pyrrolidine sulfonamides as TRPA1 antagonists.

Jun Chen, D. Hackos, J. Lyssikatos, 2016, Bioorganic & medicinal chemistry letters.

Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors

D. Sutherlin, Tianbo Li, Jun Chen, 2018, Proceedings of the National Academy of Sciences.

Role of High‐Throughput Electrophysiology in Drug Discovery

Chang Liu, Tianbo Li, Jun Chen, 2019, Current protocols in pharmacology.

Conservation and divergence in NaChBac and NaV1.7 pharmacology reveals novel drug interaction mechanisms

Tianbo Li, Jun Chen, Jonathan R. Silva, 2020, Scientific Reports.

An efficient and scalable data analysis solution for automated electrophysiology platforms.

Tianbo Li, Jun Chen, Stephan Steigele, 2021, SLAS discovery : advancing life sciences R & D.