Youhua Liu

发表

Tissue-type Plasminogen Activator Acts as a Cytokine That Triggers Intracellular Signal Transduction and Induces Matrix Metalloproteinase-9 Gene Expression*

Sakae Tanaka, S. L. Gonias, Kebin Hu, 2006, Journal of Biological Chemistry.

Hepatocyte Growth Factor Is a Downstream Effector that Mediates the Antifibrotic Action of Peroxisome Proliferator–Activated Receptor-γ Agonists

Kebin Hu, Youhua Liu, Yingjian Li, 2005 .

Hepatocyte Growth Factor Preserves Beta Cell Mass and Mitigates Hyperglycemia in Streptozotocin-induced Diabetic Mice*

Junwei Yang, Youhua Liu, Yingjian Li, 2003, Journal of Biological Chemistry.

Role of Bcl-xL induction in HGF-mediated renal epithelial cell survival after oxidant stress.

Junwei Yang, Youhua Liu, Jinglan Zhang, 2008, International journal of clinical and experimental pathology.

Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD.

Youhua Liu, Yingjian Li, Weichun He, 2012, Journal of the American Society of Nephrology : JASN.

Matrix Metalloproteinase-7 Is a Urinary Biomarker and Pathogenic Mediator of Kidney Fibrosis.

Youhua Liu, F. Hou, H. Fu, 2017, Journal of the American Society of Nephrology : JASN.

Cellular and molecular mechanisms of renal fibrosis

Youhua Liu, 2011, Nature Reviews Nephrology.

Numb contributes to renal fibrosis by promoting tubular epithelial cell cycle arrest at G2/M

Youhua Liu, F. Hou, Jing Nie, 2016, Oncotarget.

FTO regulates adipogenesis by controlling cell cycle progression via m6A-YTHDF2 dependent mechanism.

Youhua Liu, Fengqin Wang, Yizhen Wang, 2018, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Renal fibrosis: new insights into the pathogenesis and therapeutics.

Youhua Liu, Youhua Liu, 2006, Kidney international.

Long noncoding RNA lnc-TSI inhibits renal fibrogenesis by negatively regulating the TGF-β/Smad3 pathway

E. Song, Peng Wang, Youhua Liu, 2018, Science Translational Medicine.

Complement Component C5a Permits the Coexistence of Pathogenic Th17 Cells and Type I IFN in Lupus

Youhua Liu, L. Kane, M. Levesque, 2014, The Journal of Immunology.

Mutual antagonism of Wilms' tumor 1 and β-catenin dictates podocyte health and disease.

Youhua Liu, Yingjian Li, Weichun He, 2015, Journal of the American Society of Nephrology : JASN.

PINCH1 Is Transcriptional Regulator in Podocytes That Interacts with WT1 and Represses Podocalyxin Expression

Youhua Liu, Yingjian Li, Dan-ping Wang, 2011, PloS one.

Hepatocyte growth factor signaling ameliorates podocyte injury and proteinuria.

Youhua Liu, C. Dai, M. Saleem, 2010, Kidney international.

Renal expression of advanced oxidative protein products predicts progression of renal fibrosis in patients with IgA nephropathy

Zhenhai Zhang, Youhua Liu, F. Hou, 2014, Laboratory Investigation.

Smad ubiquitination regulatory factor-2 in the fibrotic kidney: regulation, target specificity, and functional implication.

Youhua Liu, Weichun He, R. Tan, 2008, American journal of physiology. Renal physiology.

Cell Phenotype-specific Down-regulation of Smad3 Involves Decreased Gene Activation as Well as Protein Degradation*

H. Schnaper, Youhua Liu, C. Runyan, 2007, Journal of Biological Chemistry.

Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling.

M. Kahn, Youhua Liu, Yingjian Li, 2015, Journal of the American Society of Nephrology : JASN.

Interferon-alpha activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes.

H. Cai, S. Strom, Youhua Liu, 2002, Gastroenterology.

The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

Youhua Liu, T. Miyata, P. Zhu, 2012, Kidney international.

Coordinated Regulation of Dimethylarginine Dimethylaminohydrolase-1 and Cationic Amino Acid Transporter-1 by Farnesoid X Receptor in Mouse Liver and Kidney and Its Implication in the Control of Blood Levels of Asymmetric Dimethylarginine

Youhua Liu, Ramalinga Kuruba, S. Poloyac, 2009, Journal of Pharmacology and Experimental Therapeutics.

mRNA m5C controls adipogenesis by promoting CDKN1A mRNA export and translation

X. Liao, Youhua Liu, Yizhen Wang, 2021, RNA biology.

m6A methylation modulates adipogenesis through JAK2-STAT3-C/EBPβ signaling.

Youhua Liu, Fengqin Wang, Yizhen Wang, 2019, Biochimica et biophysica acta. Gene regulatory mechanisms.

ZFP217 regulates adipogenesis by controlling mitotic clonal expansion in a METTL3-m6A dependent manner

Youhua Liu, Yizhen Wang, Xinxia Wang, 2019, RNA biology.

Sp1 regulates expression of MET, and ribozyme-induced down-regulation of MET in fibrosarcoma-derived human cells reduces or eliminates their tumorigenicity.

Youhua Liu, J. Laterra, R. Abounader, 2004, International journal of oncology.

Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling.

Youhua Liu, Xiaoyan Wen, Xiaoyue Tan, 2008, Journal of the American Society of Nephrology : JASN.

Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy.

Youhua Liu, Weichun He, Xiaoyue Tan, 2009, Kidney international.

Wnt/beta-catenin signaling promotes podocyte dysfunction and albuminuria.

D. Stolz, Youhua Liu, C. Dai, 2009, Journal of the American Society of Nephrology : JASN.

Blockade of Wnt/β-catenin signaling by paricalcitol ameliorates proteinuria and kidney injury.

Youhua Liu, C. Dai, Weichun He, 2011, Journal of the American Society of Nephrology : JASN.

Cannabinoid receptor type 2 promotes kidney fibrosis through orchestrating β-catenin signaling.

Youhua Liu, Lili Zhou, Nan Jia, 2020, Kidney international.

oxidative stress is mediated through the interplay Suppression of HGF receptor gene expression by

Youhua Liu, Xianghong Zhang, Xianghong Zhang, 2016 .

Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney.

Junwei Yang, Youhua Liu, Yingjian Li, 2003, American journal of physiology. Renal physiology.

Suppression of HGF receptor gene expression by oxidative stress is mediated through the interplay between Sp1 and Egr-1.

Youhua Liu, X. Zhang, Xianghong Zhang, 2003, American journal of physiology. Renal physiology.

hepatocyte growth factor is a downstream effector that mediates the antifibrotic action of peroxisome proliferator-activated receptor-gamma agonists.

Kebin Hu, Youhua Liu, Yingjian Li, 2006, Journal of the American Society of Nephrology : JASN.

Hepatocyte growth factor receptor signaling mediates the anti-fibrotic action of 9-cis-retinoic acid in glomerular mesangial cells.

Kebin Hu, Youhua Liu, Yingjian Li, 2005, The American journal of pathology.

Delayed administration of hepatocyte growth factor reduces renal fibrosis in obstructive nephropathy.

Junwei Yang, Youhua Liu, 2003, American journal of physiology. Renal physiology.

Inhibition of Proinflammatory RANTES Expression by TGF-β1 Is Mediated by Glycogen Synthase Kinase-3β-dependent β-Catenin Signaling*

Youhua Liu, Xiaoyan Wen, C. Dai, 2010, The Journal of Biological Chemistry.

Plasminogen Activator Inhibitor-1 Is a Transcriptional Target of the Canonical Pathway of Wnt/β-Catenin Signaling*

M. Kahn, Youhua Liu, Yingjian Li, 2010, The Journal of Biological Chemistry.

Hepatocyte growth factor gene therapy and angiotensin II blockade synergistically attenuate renal interstitial fibrosis in mice.

Junwei Yang, Youhua Liu, C. Dai, 2002, Journal of the American Society of Nephrology : JASN.

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis

Junwei Yang, Youhua Liu, Yingjian Li, 2003 .

Sonic hedgehog connects podocyte injury to mesangial activation and glomerulosclerosis.

D. Stolz, Yang Han, Youhua Liu, 2019, JCI insight.

Tenascin-C promotes acute kidney injury to chronic kidney disease progression by impairing tubular integrity via αvβ6 integrin signaling.

Youhua Liu, F. Hou, H. Fu, 2020, Kidney international.

Targeted inhibition of the type 2 cannabinoid receptor is a novel approach to reduce renal fibrosis.

X. Xie, Youhua Liu, Yuan Tian, 2018, Kidney international.

Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling.

Youhua Liu, Yingjian Li, R. Tan, 2013, Journal of the American Society of Nephrology : JASN.

Targeted inhibition of β-catenin/CBP signaling ameliorates renal interstitial fibrosis.

M. Kahn, Youhua Liu, Yingjian Li, 2011, Journal of the American Society of Nephrology : JASN.

Molecular basis of kidney disease

Youhua Liu, S. Bastacky, R. Tan, 2020, Essential Concepts in Molecular Pathology.

Potential role of active vitamin D in retarding the progression of chronic kidney disease.

D. de Zeeuw, Youhua Liu, L. Williams, 2006, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

Intravenous administration of hepatocyte growth factor gene ameliorates diabetic nephropathy in mice.

Junwei Yang, Youhua Liu, Yingjian Li, 2004, Journal of the American Society of Nephrology : JASN.

Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis

Youhua Liu, Yingjian Li, Xiaoyue Tan, 2007, The Journal of Steroid Biochemistry and Molecular Biology.

Wnt Signaling in Kidney Development and Disease.

Yongping Wang, Chengji J. Zhou, Youhua Liu, 2018, Progress in molecular biology and translational science.

A new model of diabetic nephropathy in C57BL/6 mice challenged with advanced oxidation protein products

Youhua Liu, Jian-wei Tian, Jiao Wan, 2018, Free radical biology & medicine.

Molecular basis of kidney disease

Youhua Liu, S. Bastacky, R. Tan, 2020, Essential Concepts in Molecular Pathology.

RANK- and c-Met-mediated signal network promotes prostate cancer metastatic colonization

Jayoung Kim, M. Freeman, Youhua Liu, 2014, Endocrine-related cancer.

Identification of matrix metalloproteinase-10 as a key mediator of podocyte injury and proteinuria.

Youhua Liu, F. Hou, Jing Nie, 2021, Kidney international.

Wnt/ -Catenin Signaling Promotes Renal Interstitial Fibrosis

Youhua Liu, Yingjian Li, C. Dai, 2009 .

Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis.

D. Stolz, Youhua Liu, Yingjian Li, 2009, Journal of the American Society of Nephrology : JASN.

Hepatocyte Growth Factor Exerts Its Anti-Inflammatory Action by Disrupting Nuclear Factor- B Signaling

G. Michalopoulos, Youhua Liu, Xiaoyan Wen, 2008 .

Epithelial-to-mesenchymal transition is a potential pathway leading to podocyte dysfunction and proteinuria.

Youhua Liu, Yingjian Li, Xiaoyan Wen, 2008, The American journal of pathology.

Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling.

G. Michalopoulos, Youhua Liu, Xiaoyan Wen, 2008, The American journal of pathology.

PINCH-1 promotes tubular epithelial-to-mesenchymal transition by interacting with integrin-linked kinase.

Youhua Liu, Yingjian Li, C. Dai, 2007, Journal of the American Society of Nephrology : JASN.

Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-γ inhibition of TGF-β1 action

G. Michalopoulos, Junwei Yang, Youhua Liu, 2006 .

Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.

Youhua Liu, Yingjian Li, Xiaoyue Tan, 2006, Journal of the American Society of Nephrology : JASN.

METTL3 inhibits BMSC adipogenic differentiation by targeting the JAK1/STAT5/C/EBPβ pathway via an m6A‐YTHDF2–dependent manner

Youhua Liu, Yizhen Wang, R. Wu, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease

Youhua Liu, Y. Liao, Lili Zhou, 2018, Scientific Reports.

Cellular Senescence in Kidney Fibrosis: Pathologic Significance and Therapeutic Strategies

Youhua Liu, Lili Zhou, Jie Xu, 2020, Frontiers in Pharmacology.

Sonic hedgehog selectively promotes lymphangiogenesis after kidney injury through noncanonical pathway.

Youhua Liu, Ying Yu, Dong Zhou, 2019, American journal of physiology. Renal physiology.

Tubular injury triggers podocyte dysfunction by β-catenin-driven release of MMP7.

D. Stolz, Youhua Liu, J. Ho, 2019, JCI insight.

The fibrogenic niche in kidney fibrosis: components and mechanisms

Youhua Liu, H. Fu, Li Li, 2022, Nature Reviews Nephrology.

A stimuli-responsive drug release nanoplatform for kidney-specific anti-fibrosis treatment.

Youhua Liu, T. Zeng, X. Geng, 2019, Biomaterials science.

Animal Models of Kidney Diseases

Youhua Liu, C. Dai, L. Kiss, 2008 .

Ageing, cellular senescence and chronic kidney disease: experimental evidence

Youhua Liu, Jie Xu, Huishi Tan, 2022, Current opinion in nephrology and hypertension.

Intensity of Macrophage Infiltration in Glomeruli Predicts Response to Immunosuppressive Therapy in Patients with IgA Nephropathy

Youhua Liu, F. Hou, D. Xie, 2021, Journal of the American Society of Nephrology : JASN.

The modulation of caveolin‐1 expression controls satellite cell activation during muscle repair

Youhua Liu, D. Volonté, Ferruccio Galbiati, 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

1,25-dihydroxyvitamin D3 inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression

Junwei Yang, Youhua Liu, Yingjian Li, 2005 .

AGE-LDL Activates Toll Like Receptor 4 Pathway and Promotes Inflammatory Cytokines Production in Renal Tubular Epithelial Cells

Youhua Liu, F. Hou, Jing Nie, 2013, International journal of biological sciences.

Follistatin-like 1 (FSTL1) interacts with Wnt ligands and Frizzled receptors to enhance Wnt/β-catenin signaling in obstructed kidneys in vivo

Youhua Liu, C. Dai, Guoxun Zheng, 2022, The Journal of biological chemistry.

IL-17 Receptor Signaling Negatively Regulates the Development of Tubulointerstitial Fibrosis in the Kidney

Youhua Liu, Bianca M. Coleman, R. Tan, 2018, Mediators of inflammation.

A renal-cerebral-peripheral sympathetic reflex mediates insulin resistance in chronic kidney disease

Youhua Liu, F. Hou, C. Wilcox, 2018, EBioMedicine.

m6A mRNA methylation controls autophagy and adipogenesis by targeting Atg5 and Atg7

Hailing Shi, Youhua Liu, Fengqin Wang, 2020, Autophagy.

FTO knockout in adipose tissue effectively alleviates hepatic steatosis partially via increasing the secretion of adipocyte-derived IL-6.

X. Liao, Youhua Liu, R. Wu, 2022, Gene.

Sympathetic Overactivity in CKD Disrupts Buffering of Neurotransmission by Endothelium-Derived Hyperpolarizing Factor and Enhances Vasoconstriction.

Youhua Liu, F. Hou, C. Wilcox, 2020, Journal of the American Society of Nephrology : JASN.

LRP5 and LRP6 in Wnt Signaling: Similarity and Divergence

Youhua Liu, Qian Ren, Jiongcheng Chen, 2021, Frontiers in Cell and Developmental Biology.

B7-1 mediates podocyte injury and glomerulosclerosis through communication with Hsp90ab1-LRP5-β-catenin pathway

Youhua Liu, F. Hou, Lili Zhou, 2022, Cell death and differentiation.

β-Cell-Specific Ablation of the Hepatocyte Growth Factor Receptor Results in Reduced Islet Size, Impaired Insulin Secretion, and Glucose Intolerance

S. Thorgeirsson, C. Huh, Youhua Liu, 2005 .

A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Youhua Liu, F. Hou, H. Fu, 2022, Nature Communications.

Klotho suppresses renal tubulo‐interstitial fibrosis by controlling basic fibroblast growth factor‐2 signalling

Youhua Liu, Jinghong Zhao, K. Sharma, 2014, The Journal of pathology.

Wnt/β-catenin signaling mediates both heart and kidney injury in type 2 cardiorenal syndrome.

Youhua Liu, Y. Liao, F. Hou, 2019, Kidney international.

Matrix metalloproteinase-10 protects against acute kidney injury by augmenting epidermal growth factor receptor signaling

Youhua Liu, Lili Zhou, Xiaoli Sun, 2021, Cell death & disease.

Wnt/&bgr;-catenin signaling and renin–angiotensin system in chronic kidney disease

Youhua Liu, Lili Zhou, 2016, Current opinion in nephrology and hypertension.

(Pro)renin Receptor Is an Amplifier of Wnt/β-Catenin Signaling in Kidney Injury and Fibrosis.

Youhua Liu, F. Hou, Lili Zhou, 2017, Journal of the American Society of Nephrology : JASN.

β‐catenin‐controlled tubular cell‐derived exosomes play a key role in fibroblast activation via the OPN‐CD44 axis

Youhua Liu, F. Hou, Lili Zhou, 2022, Journal of extracellular vesicles.

Sonic hedgehog is a novel tubule-derived growth factor for interstitial fibroblasts after kidney injury.

Youhua Liu, Yingjian Li, F. Hou, 2014, Journal of the American Society of Nephrology : JASN.

Sonic hedgehog signaling mediates epithelial-mesenchymal communication and promotes renal fibrosis.

Youhua Liu, Weichun He, F. Hou, 2012, Journal of the American Society of Nephrology : JASN.

Sustained expression of naked plasmid DNA encoding hepatocyte growth factor in mice promotes liver and overall body growth

G. Michalopoulos, Junwei Yang, Youhua Liu, 2001, Hepatology.

Tenascin-C protects against acute kidney injury by recruiting Wnt ligands.

Youhua Liu, F. Hou, H. Fu, 2019, Kidney international.

Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.

D. Stolz, Youhua Liu, H. Fu, 2017, Journal of the American Society of Nephrology : JASN.

Keap1 hypomorphism protects against ischemic and obstructive kidney disease

Youhua Liu, D. Chartoumpekis, T. Kensler, 2016, Scientific Reports.

Estrogen sulfotransferase ablation sensitizes mice to sepsis

M. Huang, M. Jiang, Youhua Liu, 2015, Nature Communications.

Early activation of fibroblasts is required for kidney repair and regeneration after injury

Youhua Liu, S. Bastacky, H. Fu, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Signaling Crosstalk between Tubular Epithelial Cells and Interstitial Fibroblasts after Kidney Injury

Youhua Liu, R. Tan, Dong Zhou, 2016, Kidney Diseases.

Renal fibrosis in 2015: Understanding the mechanisms of kidney fibrosis

Youhua Liu, Dong Zhou, 2016, Nature Reviews Nephrology.

The link between mechanical stretch and glucose metabolism—a conceptual advance in understanding diabetic (and non diabetic?) renal disease

Youhua Liu, D. Zeeuw, L. Williams, 2007 .

Matrix metalloproteinase-7 protects against acute kidney injury by priming renal tubules for survival and regeneration.

Youhua Liu, F. Hou, H. Fu, 2019, Kidney international.

Wnt/β‐catenin/RAS signaling mediates age‐related renal fibrosis and is associated with mitochondrial dysfunction

Youhua Liu, F. Hou, Lili Zhou, 2019, Aging cell.

Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition.

Youhua Liu, R. Xiang, M. Xiong, 2012, American journal of physiology. Renal physiology.

mRNA m5C inhibits adipogenesis and promotes myogenesis by respectively facilitating YBX2 and SMO mRNA export in ALYREF-m5C manner

Youhua Liu, Yizhen Wang, Ying Yang, 2022, Cellular and Molecular Life Sciences.

Wnt/β-catenin links oxidative stress to podocyte injury and proteinuria.

Youhua Liu, F. Hou, Jing Nie, 2019, Kidney international.

Loss of Klotho in CKD Breaks One's Heart.

Youhua Liu, H. Fu, 2015, Journal of the American Society of Nephrology : JASN.

The fibrogenic niche in kidney fibrosis: components and mechanisms

Youhua Liu, H. Fu, Li Li, 2022, Nature Reviews Nephrology.

Matrix Metalloproteinase-10 in Kidney Injury Repair and Disease

Youhua Liu, Xiaoli Sun, 2022, International journal of molecular sciences.

Non-canonical Wnt/calcium signaling is protective against podocyte injury and glomerulosclerosis.

D. Stolz, Dong Zhou, Youhua Liu, 2022, Kidney international.

New insights into the role and mechanism of Wnt/β‐catenin signalling in kidney fibrosis

Youhua Liu, Yangyang Zuo, 2018, Nephrology.

Fibroblast-Specific β-Catenin Signaling Dictates the Outcome of AKI.

Youhua Liu, Jianhua Xing, H. Fu, 2018, Journal of the American Society of Nephrology : JASN.

Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor.

Junwei Yang, Youhua Liu, Yingjian Li, 2007, Journal of the American Society of Nephrology : JASN.

Canonical Wnt/β-catenin signaling mediates transforming growth factor-β1-driven podocyte injury and proteinuria.

Youhua Liu, Yingjian Li, C. Dai, 2011, Kidney international.

Theranostics A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells

Youhua Liu, F. Hou, Lili Zhou, 2022 .

Extracellular Superoxide Dismutase Protects against Proteinuric Kidney Disease.

Youhua Liu, T. Oury, Yingjian Li, 2015, Journal of the American Society of Nephrology : JASN.

Macrophage-derived TGF-β in renal fibrosis: not a macro-impact after all.

Youhua Liu, R. Tan, 2013, American journal of physiology. Renal physiology.

Tubular cell dedifferentiation and peritubular inflammation are coupled by the transcription regulator Id1 in renal fibrogenesis

Youhua Liu, Yingjian Li, Xiaoyan Wen, 2011, Kidney international.

Activation of Wnt/β‐catenin pathway during hepatocyte growth factor–induced hepatomegaly in mice

B. Cieply, K. Kaestner, Youhua Liu, 2006, Hepatology.

Metformin combats obesity by targeting FTO in an m6A-YTHDF2-dependent manner

Youhua Liu, Yizhen Wang, Xinxia Wang, 2022, Journal of drug targeting.

m6A methylation promotes white‐to‐beige fat transition by facilitating Hif1a translation

X. Liao, Youhua Liu, Yizhen Wang, 2021, EMBO reports.

Identification ofaCell-Type-Specif ic Transcriptional Repressor inthePromoter Region oftheMouseHepatocyte GrowthFactor Gene

Youhua Liu, 1994 .

Sustained Activation of Wnt/β-Catenin Signaling Drives AKI to CKD Progression.

Youhua Liu, F. Hou, H. Fu, 2016, Journal of the American Society of Nephrology : JASN.

Wnt/β-catenin signaling and kidney fibrosis

Youhua Liu, R. Tan, Dong Zhou, 2014, Kidney international supplements.

Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice

P. Igarashi, Youhua Liu, Yingjian Li, 2012, Kidney international.

Tubule-Derived Wnts Are Required for Fibroblast Activation and Kidney Fibrosis.

Kecheng Zhang, Youhua Liu, S. Bastacky, 2017, Journal of the American Society of Nephrology : JASN.

Therapy for kidney fibrosis: is the Src kinase a potential target?

Youhua Liu, Dong Zhou, 2016, Kidney international.

Endothelin Receptor A Blockade Is an Ineffective Treatment for Adriamycin Nephropathy

Youhua Liu, R. Tan, Dong Zhou, 2013, PloS one.

Chronic kidney disease: Fibrosis and anaemia in CKD—two beasts, one ancestor

Youhua Liu, Liangxiang Xiao, 2013, Nature Reviews Nephrology.

Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication

Youhua Liu, Yingjian Li, R. Tan, 2013, Scientific Reports.

Inhibition of integrin-linked kinase blocks podocyte epithelial-mesenchymal transition and ameliorates proteinuria.

Youhua Liu, Yingjian Li, C. Dai, 2010, Kidney international.

Exogenous Wnt1 Prevents Acute Kidney Injury and Its Subsequent Progression to Chronic Kidney Disease

Youhua Liu, Liangxiang Xiao, Tian-Jun Guan, 2021, Frontiers in Physiology.

CXCR4 induces podocyte injury and proteinuria by activating β-catenin signaling

Youhua Liu, F. Hou, Dong Zhou, 2022, Theranostics.

Type I IFN in Lupus Coexistence of Pathogenic Th17 Cells and Complement Component C5a Permits the

Youhua Liu, L. Kane, M. Levesque, 2014 .

C-X-C Chemokine Receptor Type 4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury.

Youhua Liu, F. Hou, Lili Zhou, 2017, Antioxidants & redox signaling.

Wnt9a Promotes Renal Fibrosis by Accelerating Cellular Senescence in Tubular Epithelial Cells.

Li Yang, Youhua Liu, F. Hou, 2018, Journal of the American Society of Nephrology : JASN.

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

Youhua Liu, Lili Zhou, 2015, Nature Reviews Nephrology.

C‐X‐C motif chemokine receptor 4 aggravates renal fibrosis through activating JAK/STAT/GSK3β/β‐catenin pathway

Youhua Liu, F. Hou, Yanqiu Feng, 2020, Journal of cellular and molecular medicine.

Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair

Youhua Liu, F. Hou, Zhanmei Zhou, 2022, Nature Communications.

Cannabinoid receptor 2 plays a central role in renal tubular mitochondrial dysfunction and kidney ageing

Youhua Liu, Lili Zhou, P. Meng, 2021, Journal of cellular and molecular medicine.

Annexin A2 plays a key role in protecting against cisplatin-induced AKI through β-catenin/TFEB pathway

Youhua Liu, Lili Zhou, Qingyou Zhou, 2022, Cell Death Discovery.

1,25-dihydroxyvitamin D inhibits renal interstitial myofibroblast activation by inducing hepatocyte growth factor expression.

Junwei Yang, Youhua Liu, Yingjian Li, 2005, Kidney international.

studies, as noted above, have unraveled novel cellular and molecular insights into the lithium’s effects on renal tubular cells in AKI and in NDI. ACKNOWLEDGMENTS

Youhua Liu, R. Tan, 2014 .

Epithelial to mesenchymal transition in renal fibrogenesis: pathologic significance, molecular mechanism, and therapeutic intervention.

Youhua Liu, 2004, Journal of the American Society of Nephrology : JASN.

Downregulation of Smad transcriptional corepressors SnoN and Ski in the fibrotic kidney: an amplification mechanism for TGF-beta1 signaling.

Junwei Yang, Youhua Liu, Xianghong Zhang, 2003, Journal of the American Society of Nephrology : JASN.

Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation.

Youhua Liu, G. Michalopoulos, Youhua Liu, 2006, The American journal of pathology.

CHAPTER 32 – Hepatocyte growth factor and its receptor, MET

W. Mars, Youhua Liu, S. Monga, 2003 .

MiR-382 targeting of kallikrein 5 contributes to renal inner medullary interstitial fibrosis.

Y. Liu, Mingyu Liang, Youhua Liu, 2012, Physiological genomics.

Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells.

Junwei Yang, Youhua Liu, Xianghong Zhang, 2005, American journal of physiology. Renal physiology.

Interferon-α activates multiple STAT signals and down-regulates c-Met in primary human hepatocytes

H. Cai, S. Strom, Youhua Liu, 2002 .

MicroRNA-10 negatively regulates inflammation in diabetic kidney via targeting activation of NLRP3 inflammasome.

Youhua Liu, F. Hou, Minliang Yang, 2021, Molecular therapy : the journal of the American Society of Gene Therapy.

A dynamic reversible RNA N6‐methyladenosine modification: current status and perspectives

Youhua Liu, Yizhen Wang, Xinxia Wang, 2019, Journal of cellular physiology.

Essential role of integrin-linked kinase in podocyte biology: Bridging the integrin and slit diaphragm signaling.

D. Stolz, S. Dedhar, Youhua Liu, 2006, Journal of the American Society of Nephrology : JASN.

The hepatocyte growth factor/c-met pathway is a key determinant of the fibrotic kidney local microenvironment

Yanbao Yu, Yanjiao Zhou, Youhua Liu, 2021, iScience.

Hepatocyte growth factor in kidney fibrosis: therapeutic potential and mechanisms of action.

Youhua Liu, 2004, American journal of physiology. Renal physiology.

Transforming Growth Factor-β1 Potentiates Renal Tubular Epithelial Cell Death by a Mechanism Independent of Smad Signaling*

Junwei Yang, Youhua Liu, C. Dai, 2003, The Journal of Biological Chemistry.

J Am Soc Nephrol 14: 1254–1271, 2003 Urokinase Receptor Deficiency Accelerates Renal Fibrosis in Obstructive Nephropathy

P. Carmeliet, C. Alpers, Youhua Liu, 2022 .

Transforming growth factor-β (TGF-β) activates cytosolic phospholipase A2α (cPLA2α)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated-γ (PPAR-γ)/Smad signaling pathways in human liver cancer cells. A NOVEL MECHANISM FOR SUBVERSION OF TGF-β-INDUCED MITOINHIBITION.

J. Shelhamer, Youhua Liu, A. Demetris, 2004, The Journal of Biological Chemistry.

Transforming Growth Factor-β (TGF-β) Activates Cytosolic Phospholipase A2α (cPLA2α)-mediated Prostaglandin E2 (PGE)2/EP1 and Peroxisome Proliferator-activated Receptor-γ (PPAR-γ)/Smad Signaling Pathways in Human Liver Cancer Cells

J. Shelhamer, Youhua Liu, A. Demetris, 2004, Journal of Biological Chemistry.

New insights into epithelial-mesenchymal transition in kidney fibrosis.

Youhua Liu, 2010, Journal of the American Society of Nephrology : JASN.

Wnt/beta-catenin signaling promotes renal interstitial fibrosis.

Youhua Liu, C. Dai, Weichun He, 2009, Journal of the American Society of Nephrology : JASN.

Transcriptional Regulation of the Hepatocyte Growth Factor Gene by the Nuclear Receptors Chicken Ovalbumin Upstream Promoter Transcription Factor and Estrogen Receptor*

A. Bell, Youhua Liu, R. Zarnegar, 1997, The Journal of Biological Chemistry.

Modulation of hepatocyte growth factor gene expression by estrogen in mouse ovary

Youhua Liu, R. Zarnegar, Lin Lin, 1994, Molecular and Cellular Endocrinology.

Myofibroblast in Kidney Fibrosis: Origin, Activation, and Regulation.

Youhua Liu, R. Tan, Q. Yuan, 2019, Advances in experimental medicine and biology.

Hepatocyte growth factor promotes renal epithelial cell survival by dual mechanisms.

Youhua Liu, 1999, American journal of physiology. Renal physiology.

Sonic hedgehog signaling in kidney fibrosis: a master communicator

Youhua Liu, R. Tan, Dong Zhou, 2016, Science China Life Sciences.

Author Correction: A Klotho-derived peptide protects against kidney fibrosis by targeting TGF-β signaling

Youhua Liu, F. Hou, H. Fu, 2022, Nature Communications.

Hepatocyte growth factor suppresses renal interstitial myofibroblast activation and intercepts Smad signal transduction.

Junwei Yang, Youhua Liu, C. Dai, 2003, The American journal of pathology.

Role for integrin-linked kinase in mediating tubular epithelial to mesenchymal transition and renal interstitial fibrogenesis.

Junwei Yang, Youhua Liu, C. Dai, 2003, The Journal of clinical investigation.

Disruption of tissue-type plasminogen activator gene in mice reduces renal interstitial fibrosis in obstructive nephropathy.

Junwei Yang, W. Mars, Youhua Liu, 2002, The Journal of clinical investigation.

Blockage of tubular epithelial to myofibroblast transition by hepatocyte growth factor prevents renal interstitial fibrosis.

Junwei Yang, Youhua Liu, 2002, Journal of the American Society of Nephrology : JASN.

GQ5 Hinders Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-β-Induced Smad3 Phosphorylation.

Youhua Liu, F. Hou, Jing Nie, 2015, Journal of the American Society of Nephrology : JASN.

tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis.

Ling Lin, Kebin Hu, W. Mars, 2008, Journal of the American Society of Nephrology : JASN.

Tissue-type plasminogen activator promotes murine myofibroblast activation through LDL receptor-related protein 1-mediated integrin signaling.

Kebin Hu, W. Mars, Youhua Liu, 2007, The Journal of clinical investigation.

Tubule-derived exosomes play a central role in fibroblast activation and kidney fibrosis.

Youhua Liu, F. Hou, Lili Zhou, 2019, Kidney international.

tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling.

W. Mars, Youhua Liu, Hongmei Shen, 2010, The American journal of pathology.

Role of 1 Integrin/Focal Adhesion Kinase Signaling

W. Mars, Youhua Liu, Hongmei Shen, 2010 .

Single injection of naked plasmid encoding hepatocyte growth factor prevents cell death and ameliorates acute renal failure in mice.

Junwei Yang, Youhua Liu, C. Dai, 2002, Journal of the American Society of Nephrology : JASN.

High Fat Diet Induces Kidney Injury via Stimulating Wnt/β-Catenin Signaling

Youhua Liu, Hui Zhuo, Chen Yu, 2022, Frontiers in Medicine.

Hepatocyte growth factor antagonizes the profibrotic action of TGF-beta1 in mesangial cells by stabilizing Smad transcriptional corepressor TGIF.

Youhua Liu, C. Dai, 2004, Journal of the American Society of Nephrology : JASN.

Contrast-Enhanced Ultrasound for Assessing Renal Perfusion Impairment and Predicting Acute Kidney Injury to Chronic Kidney Disease Progression.

Li Yang, Youhua Liu, F. Hou, 2017, Antioxidants & redox signaling.

Albumin overload activates intrarenal renin–angiotensin system through protein kinase C and NADPH oxidase-dependent pathway

Youhua Liu, F. Hou, Jing Nie, 2011, Journal of hypertension.

Wnt/β-catenin signaling in kidney injury and repair: a double-edged sword

Youhua Liu, H. Fu, R. Tan, 2015, Laboratory Investigation.

Matrix metalloproteinases in kidney homeostasis and diseases.

Youhua Liu, R. Tan, 2012, American journal of physiology. Renal physiology.

Insulin-like growth factor 2 mRNA-binding protein 3 promotes kidney injury by regulating β-catenin signaling

Youhua Liu, F. Hou, H. Fu, 2022, JCI insight.

The Many Faces of Matrix Metalloproteinase-7 in Kidney Diseases

Youhua Liu, R. Tan, Zhao Liu, 2020, Biomolecules.

Fibrillin-1–enriched microenvironment drives endothelial injury and vascular rarefaction in chronic kidney disease

Youhua Liu, F. Hou, H. Fu, 2021, Science Advances.

Wnt/β-catenin regulates blood pressure and kidney injury in rats.

Youhua Liu, F. Hou, H. Fu, 2019, Biochimica et biophysica acta. Molecular basis of disease.

Curcumin prevents obesity by targeting TRAF4‐induced ubiquitylation in m6A‐dependent manner

X. Liao, Youhua Liu, Yizhen Wang, 2021, EMBO reports.

Role of miRNA-671-5p in Mediating Wnt/β-Catenin-Triggered Podocyte Injury

Youhua Liu, Lili Zhou, Xiao-yan Bai, 2022, Frontiers in Pharmacology.

DHA alleviates diet-induced skeletal muscle fiber remodeling via FTO/m6A/DDIT4/PGC1α signaling

Youhua Liu, Yizhen Wang, R. Wu, 2022, BMC biology.

Adipocytes initiates an adipose-cerebral-peripheral sympathetic reflex to induce insulin resistance during high fat feeding.

Youhua Liu, F. Hou, C. Wilcox, 2019, Clinical science.

The Upstream Regulatory Regions of the Hepatocyte Growth Factor Gene Promoter Are Essential for Its Expression in Transgenic Mice*

A. Bell, Youhua Liu, R. Zarnegar, 1998, The Journal of Biological Chemistry.

An essential role for Wnt/β-catenin signaling in mediating hypertensive heart disease

Youhua Liu, Y. Liao, Lili Zhou, 2018, Scientific Reports.

Opposite Action of Peroxisome Proliferator-activated Receptor-γ in Regulating Renal Inflammation

Youhua Liu, Xiaoyan Wen, Yingjian Li, 2010, The Journal of Biological Chemistry.

m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner

Youhua Liu, Fengqin Wang, Yizhen Wang, 2019, Cell Death & Disease.

A New Criterion for Pediatric AKI Based on the Reference Change Value of Serum Creatinine.

H. Xia, Youhua Liu, W. Zhou, 2018, Journal of the American Society of Nephrology : JASN.

Klotho Ameliorates Kidney Injury and Fibrosis and Normalizes Blood Pressure by Targeting the Renin-Angiotensin System.

Youhua Liu, F. Hou, R. Tan, 2015, The American journal of pathology.

Tubular epithelial cell dedifferentiation is driven by the helix-loop-helix transcriptional inhibitor Id1.

S. Dedhar, Jian-Hua Luo, Junwei Yang, 2007, Journal of the American Society of Nephrology : JASN.

Identification of the estrogen sensitive marker in human endometrial carcinoma RL95-2 cells

Youhua Liu, C. Teng, 1994, Molecular and Cellular Endocrinology.

A novel mechanism by which hepatocyte growth factor blocks tubular epithelial to mesenchymal transition.

Junwei Yang, Youhua Liu, C. Dai, 2004, Journal of the American Society of Nephrology : JASN.

Advanced oxidation protein products: a causative link between oxidative stress and podocyte depletion.

Youhua Liu, 2009, Kidney international.

Urinary Matrix Metalloproteinase-7 Predicts Severe AKI and Poor Outcomes after Cardiac Surgery.

Youhua Liu, F. Hou, Chunbo Chen, 2017, Journal of the American Society of Nephrology : JASN.

Klotho-derived peptide 6 ameliorates diabetic kidney disease by targeting Wnt/β-catenin signaling.

Youhua Liu, F. Hou, H. Fu, 2022, Kidney international.

Reno-Cerebral Reflex Activates the Renin-Angiotensin System, Promoting Oxidative Stress and Renal Damage After Ischemia-Reperfusion Injury.

Youhua Liu, F. Hou, C. Wilcox, 2017, Antioxidants & redox signaling.

A kidney-brain neural circuit drives progressive kidney damage and heart failure

Youhua Liu, F. Hou, C. Wilcox, 2023, Signal transduction and targeted therapy.

Hepatocyte growth factor and the kidney

Youhua Liu, 2002, Current opinion in nephrology and hypertension.

Sequential Wnt Agonist Then Antagonist Treatment Accelerates Tissue Repair and Minimizes Fibrosis

Sui Huang, Youhua Liu, Jianhua Xing, 2018, iScience.

Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury

Youhua Liu, R. Tan, Dong Zhou, 2013, Kidney international.

Novel actions of tissue-type plasminogen activator in chronic kidney disease.

Kebin Hu, W. Mars, Youhua Liu, 2008, Frontiers in bioscience : a journal and virtual library.

New insights into the pathogenesis and therapeutics of kidney fibrosis

Youhua Liu, F. Hou, 2014, Kidney international supplements.

lncRNA lnc-TSI Inhibits Metastasis of Clear Cell Renal Cell Carcinoma by Suppressing TGF-β-Induced Epithelial-Mesenchymal Transition

Peng Wang, Youhua Liu, F. Hou, 2020, Molecular therapy. Nucleic acids.

m6A methylation controls pluripotency of porcine induced pluripotent stem cells by targeting SOCS3/JAK2/STAT3 pathway in a YTHDF1/YTHDF2-orchestrated manner

Youhua Liu, Fengqin Wang, Yizhen Wang, 2019, Cell Death & Disease.

A new LKB1 activator, piericidin analogue S14, retards renal fibrosis through promoting autophagy and mitochondrial homeostasis in renal tubular epithelial cells

Youhua Liu, F. Hou, Xuefeng Zhou, 2022, Theranostics.

Kindlin-2 mediates activation of TGF-β/Smad signaling and renal fibrosis.

Youhua Liu, F. Hou, Jing Nie, 2013, Journal of the American Society of Nephrology : JASN.

Renal Fibrosis in Obstructive Nephropathy by Selectively Inhibiting TGF-b – Induced Smad 3 Phosphorylation

Youhua Liu, F. Hou, Jing Nie, 2014 .

Activation of Constitutive Androstane Receptor Ameliorates Renal Ischemia-Reperfusion–Induced Kidney and Liver Injury

T. Nolin, Youhua Liu, W. Xie, 2018, Molecular Pharmacology.

Trade-off between Quick Repair and Complete Resolution Complicates Recovery from Kidney Injury

Sui Huang, Youhua Liu, Jianhua Xing, 2018, 1810.03687.

Sonic hedgehog signaling in kidney fibrosis: a master communicator

Youhua Liu, R. Tan, Dong Zhou, 2016, Science China Life Sciences.

Inhibition of Estrogen Sulfotransferase (SULT1E1/EST) Ameliorates Ischemic Acute Kidney Injury in Mice.

Dong Zhou, Youhua Liu, You-Jin Choi, 2020, Journal of the American Society of Nephrology : JASN.

MicroRNA‐466o‐3p mediates β‐catenin‐induced podocyte injury by targeting Wilms tumor 1

Youhua Liu, Lili Zhou, Xiaowen Chen, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation.

Junwei Yang, Youhua Liu, Jinglan Zhang, 2006, Journal of the American Society of Nephrology : JASN.

Limonin, a natural ERK2 agonist, protects against ischemic acute kidney injury

Dong Zhou, Youhua Liu, F. Hou, 2023, International journal of biological sciences.

Modulation of c-MET proto-oncogene (HGF receptor) mRNA abundance by cytokines and hormones: evidence for rapid decay of the 8 kb c-MET transcript.

L. Lin, Youhua Liu, R. Zarnegar, 1994, Oncogene.

Dissection of key events in tubular epithelial to myofibroblast transition and its implications in renal interstitial fibrosis.

Junwei Yang, Youhua Liu, J. Yang, 2001, The American journal of pathology.

Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-activated receptor-gamma (PPAR-gamma)/Smad signaling pathways in human liver cancer cells. A novel mechanism for subversion of TGF-beta-i

J. Shelhamer, Youhua Liu, Tong Wu, 2004, Journal of Biological Chemistry.

Controlling Trade-Off Between Acute Injury Repair and Chronic Fibrosis with Biphasic Wnt-agonist/antagonist Treatment

Sui Huang, Youhua Liu, Jianhua Xing, 2018 .

New insights into epithelial-mesenchymal transition in kidney fibrosis.

Youhua Liu, 2010, Journal of the American Society of Nephrology : JASN.

tPA is a potent mitogen for renal interstitial fibroblasts: role of beta1 integrin/focal adhesion kinase signaling.

W. Mars, Youhua Liu, Hongmei Shen, 2010, The American journal of pathology.

Molecular basis for the cell type specific induction of SnoN expression by hepatocyte growth factor.

Junwei Yang, Youhua Liu, R. Tan, 2007, Journal of the American Society of Nephrology : JASN.

Wnt/β-catenin signalling and podocyte dysfunction in proteinuric kidney disease

Youhua Liu, Lili Zhou, 2015, Nature Reviews Nephrology.

Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling.

Youhua Liu, Xiaoyan Wen, Xiaoyue Tan, 2008, Journal of the American Society of Nephrology : JASN.

(Pro)renin Receptor Is an Amplifier of Wnt/β-Catenin Signaling in Kidney Injury and Fibrosis.

Youhua Liu, F. Hou, Lili Zhou, 2017, Journal of the American Society of Nephrology : JASN.

Macrophage promotes fibroblast activation and kidney fibrosis by assembling a vitronectin-enriched microenvironment

Youhua Liu, F. Hou, Haili Zhu, 2023, Theranostics.

Arrestin(g) podocyte injury with endothelin antagonism.

Youhua Liu, R. Tan, 2014, Journal of the American Society of Nephrology : JASN.

C-X-C Chemokine Receptor Type 4 Plays a Crucial Role in Mediating Oxidative Stress-Induced Podocyte Injury.

Youhua Liu, F. Hou, Lili Zhou, 2017, Antioxidants & redox signaling.

Urinary Matrix Metalloproteinase 7 and Prediction of IgA Nephropathy Progression.

Youhua Liu, Hong Zhang, F. Hou, 2020, American journal of kidney diseases : the official journal of the National Kidney Foundation.

The receptor of advanced glycation end products plays a central role in advanced oxidation protein products-induced podocyte apoptosis.

Youhua Liu, T. Miyata, P. Zhu, 2012, Kidney international.

Youhua Liu, Ramalinga Kuruba, S. Poloyac, 2009, Journal of Pharmacology and Experimental Therapeutics.

Loss of Klotho in CKD Breaks One's Heart.

Youhua Liu, H. Fu, 2015, Journal of the American Society of Nephrology : JASN.

Pentraxin 3 plays a key role in tubular cell senescence and renal fibrosis through inducing β-catenin signaling.

Youhua Liu, F. Hou, Lili Zhou, 2023, Biochimica et biophysica acta. Molecular basis of disease.

Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.

D. Stolz, Youhua Liu, H. Fu, 2017, Journal of the American Society of Nephrology : JASN.

Beta-cell-specific ablation of the hepatocyte growth factor receptor results in reduced islet size, impaired insulin secretion, and glucose intolerance.

S. Thorgeirsson, C. Huh, Youhua Liu, 2005, The American journal of pathology.