D. Graves

发表

Diabetes and Its Effect on Bone and Fracture Healing

Hongli Jiao, E. Xiao, D. Graves, 2015, Current Osteoporosis Reports.

TNF-α Mediates Diabetes-Enhanced Chondrocyte Apoptosis During Fracture Healing and Stimulates Chondrocyte Apoptosis Through FOXO1

Thomas A Einhorn, Louis C Gerstenfeld, Jody McLean, 2010, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

FOXO1 Functions as a Master Switch That Regulates Gene Expression Necessary for Tumor Necrosis Factor-induced Fibroblast Apoptosis*

D. Graves, M. Alikhani, Z. Alikhani, 2005, Journal of Biological Chemistry.

Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status

E. Xiao, D. Graves, E. Leys, 2017, Microbiome.

Antibody to Mac-1 or monocyte chemoattractant protein-1 inhibits monocyte recruitment and promotes tumor growth.

D. Graves, L. Zhang, T. Yoshimura, 1997, Journal of immunology.

Three-dimensional Reconstruction of Fracture Callus Morphogenesis

K. Jepsen, E. Krall, D. Graves, 2006, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Periodontal disease as a complication of diabetes mellitus

G. Taylor, D. Graves, I. Lamster, 2014 .

FOXO1 regulates VEGFA expression and promotes angiogenesis in healing wounds

D. Graves, Chenying Zhang, P. Coelho, 2018, The Journal of pathology.

Quantitative analysis of periodontal defects in a skull model by subtraction radiography using a digital imaging device.

D. Graves, D. Cochran, P. Nummikoski, 1996, The Journal of Periodontology.

FOXO1 plays an essential role in apoptosis of retinal pericytes

D. Graves, M. Alikhani, Sayon Roy, 2010, Molecular Vision.

Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin, and Orthodontic Tooth Movement)

D. Graves, R. Kayal, G. Garlet, 2015 .

15 – Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement)

D. Graves, R. Kayal, G. Garlet, 2011 .

The impact of diabetes on periodontal diseases.

D. Graves, Zhenjiang Ding, Ying-ming Yang, 2020, Periodontology 2000.

Chemokine expression is upregulated in chondrocytes in diabetic fracture healing.

Thomas A Einhorn, Chen Tian, D. Graves, 2013, Bone.

Foxo1 Inhibits Diabetic Mucosal Wound Healing but Enhances Healing of Normoglycemic Wounds

Bhaskar Ponugoti, D. Graves, Chenying Zhang, 2014, Diabetes.

Diminished Bone Formation During Diabetic Fracture Healing is Related to the Premature Resorption of Cartilage Associated With Increased Osteoclast Activity

D. Graves, S. Kakar, R. Kayal, 2007, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

TNF‐α in vivo stimulates apoptosis in fibroblasts through caspase‐8 activation and modulates the expression of pro‐apoptotic genes

D. Graves, M. Alikhani, Z. Alikhani, 2004, Journal of cellular physiology.

Mucosal Immunity and the FOXO1 Transcription Factors

D. Graves, T. Milovanova, 2019, Front. Immunol..

Cytokines that promote periodontal tissue destruction.

D. Graves, 2008, Journal of periodontology.

Study of the growth factor requirements of human bone-derived cells: a comparison with human fibroblasts.

D. Graves, J. Piché, 1989, Bone.

Interleukin-1 and tumor necrosis factor antagonists inhibit the progression of inflammatory cell infiltration toward alveolar bone in experimental periodontitis.

D. Graves, D. Cochran, S. Amar, 1998, Journal of periodontology.

Identification of monocyte chemotactic activity produced by malignant cells.

A. J. Valente, D. Graves, M. J. Williamson, 1989, Science.

Platelet-derived growth factor is not chemotactic for human peripheral blood monocytes.

Gary R. Grotendorst, A. J. Valente, D. Graves, 1989, Experimental cell research.

Cigarette Smoke Exposure Inhibits Osteoclast Apoptosis via the mtROS Pathway

J. Feng, D. Graves, S. Mei, 2021, Journal of dental research.

Expression of monocyte chemoattractant protein 1 mRNA in human idiopathic pulmonary fibrosis.

A. J. Valente, D. Graves, H. Antoniades, 1992, Proceedings of the National Academy of Sciences of the United States of America.

BMP2 is essential for post natal osteogenesis but not for recruitment of osteogenic stem cells.

D. Graves, T. Einhorn, L. Gerstenfeld, 2009, Bone.

Diabetes enhances mRNA levels of proapoptotic genes and caspase activity, which contribute to impaired healing.

D. Graves, Rongkun Liu, Y. Behl, 2006, Diabetes.

Apoptosis in Gingival Overgrowth Tissues

D. Graves, P. Trackman, A. Kantarcı, 2007, Journal of dental research.

Methotrexate promotes recovery of arthritis-induced alveolar bone loss and modifies the composition of the oral-gut microbiota.

G. Fernandes, D. Graves, F. Cunha, 2022, Anaerobe.

RANKL deletion in periodontal ligament and bone lining cells blocks orthodontic tooth movement

D. Graves, H. H. Jeon, Chia-Ying Yang, 2018, International Journal of Oral Science.

Diabetes Activates Periodontal Ligament Fibroblasts via NF-κB In Vivo

D. Graves, J. Feng, M. L. Albiero, 2018, Journal of dental research.

The enduring importance of animal modelsin understanding periodontal disease

D. Graves, R. Lamont, G. Hajishengallis, 2015, Virulence.

Diabetes alters the response to bacteria by enhancing fibroblast apoptosis.

D. Graves, Hongbin He, Rongkun Liu, 2004, Endocrinology.

Inflammation is More Persistent in Type 1 Diabetic Mice

E. Krall, D. Graves, G. Naguib, 2005, Journal of dental research.

Altered Fibroblast Proliferation and Apoptosis in Diabetic Gingival Wounds

D. Graves, T. Chino, T. Desta, 2010, Journal of dental research.

A role for advanced glycation end products in diminished bone healing in type 1 diabetes.

D. Graves, S. Amar, P. Trackman, 2003, Diabetes.

Tumor Necrosis Factor- (cid:1) Mediates Diabetes-Enhanced Apoptosis of Matrix-Producing Cells and Impairs Diabetic Healing

D. Graves, Rongkun Liu, Y. Behl, 2022 .

Diabetes prolongs the inflammatory response to a bacterial stimulus through cytokine dysregulation.

D. Graves, G. Naguib, H. Al-Mashat, 2004, The Journal of investigative dermatology.

The contribution of interleukin-1 and tumor necrosis factor to periodontal tissue destruction.

D. Graves, D. Cochran, 2003, Journal of periodontology.

Monocyte chemoattractant protein-1 regulates adhesion molecule expression and cytokine production in human monocytes.

D. Graves, G. Frendl, D. Beller, 1992, Journal of immunology.

Sustained, localized salicylic acid delivery enhances diabetic bone regeneration via prolonged mitigation of inflammation.

J. Fiorellini, D. Graves, K. Uhrich, 2016, Journal of biomedical materials research. Part A.

Immunization Enhances Inflammation and Tissue Destruction in Response to Porphyromonas gingivalis

D. Graves, S. Amar, M. Siqueira, 2006, Infection and Immunity.

The use of rodent models to investigate host-bacteria interactions related to periodontal diseases.

D. Graves, D. Fine, G. Hajishengallis, 2008, Journal of clinical periodontology.

Soluble antagonists to interleukin-1 (IL-1) and tumor necrosis factor (TNF) inhibits loss of tissue attachment in experimental periodontitis.

D. Graves, D. Cochran, Z. Schwartz, 2001, Journal of clinical periodontology.

Impaired wound healing in mouse models of diabetes is mediated by TNF-α dysregulation and associated with enhanced activation of forkhead box O1 (FOXO1)

D. Graves, M. Siqueira, M. Alikhani, 2010, Diabetologia.

Clinical application of a FOXO1 inhibitor improves connective tissue healing in a diabetic minipig model.

D. Graves, F. Alawi, M. Shin, 2021, American journal of translational research.

FOXO1 has a Dual Function to Promote Normal but Inhibit Diabetic Wound Healing

D. Graves, 2017 .

FOXO1 expression in keratinocytes promotes connective tissue healing

Bhaskar Ponugoti, D. Graves, Chenying Zhang, 2017, Scientific Reports.

FOXO1 deletion in keratinocytes improves diabetic wound healing through MMP9 regulation

D. Graves, Chenying Zhang, Fanxing Xu, 2017, Scientific Reports.

Abnormal Cell Repsonses and Role of TNF-α in Impaired Diabetic Wound Healing

D. Graves, Chenying Zhang, Fanxing Xu, 2015 .

Abnormal Cell Responses and Role of TNF-α in Impaired Diabetic Wound Healing

D. Graves, Chenying Zhang, Fanxing Xu, 2013, BioMed research international.

Mammalian Target of Rapamycin Complex 2 (mTORC2) Negatively Regulates Toll-like Receptor 4-mediated Inflammatory Response via FoxO1*

J. Suttles, D. Graves, Michael Martin, 2011, The Journal of Biological Chemistry.

Diabetes-enhanced tumor necrosis factor-alpha production promotes apoptosis and the loss of retinal microvascular cells in type 1 and type 2 models of diabetic retinopathy.

D. Graves, A. DiPiazza, Sayon Roy, 2008, American Journal of Pathology.

IL-1 Plays a Critical Role in Oral, But Not Dermal, Wound Healing

D. Graves, S. Amar, Shilpa Patel, 2001, The Journal of Immunology.

Healing is delayed in oral compared to dermal excisional wounds.

D. Graves, N. Nooh, 2003, Journal of periodontology.

Influence of diabetes on the exacerbation of an inflammatory response in cardiovascular tissue.

D. Graves, S. Amar, M. Raptis, 2004, Endocrinology.

Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.

D. Graves, L. Gerstenfeld, M. Alikhani, 2007, Bone.

Activation of the Acquired Immune Response Reduces Coupled Bone Formation in Response to a Periodontal Pathogen1

D. Graves, M. Siqueira, D. Faibish, 2008, The Journal of Immunology.

Bone Remodeling Under Pathological Conditions.

D. Graves, Yu Wang, W. Xiao, 2016, Frontiers of oral biology.

Periodontal Disease and Inflammation-Induced Bone Remodeling

J. Fiorellini, D. Graves, E. Rosenstein, 2013 .

Animal models to study host-bacteria interactions involved in periodontitis.

D. Graves, C. Rossa, K. Wada, 2012, Frontiers of oral biology.

Inflammation and Uncoupling as Mechanisms of Periodontal Bone Loss

D. Graves, D. Cochran, J. Li, 2011, Journal of dental research.

Periodontal disease: bacterial virulence factors, host response and impact on systemic health.

D. Graves, C. Genco, Yanling Jiang, 2000, Current opinion in infectious diseases.

Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss.

Louis C Gerstenfeld, D. Graves, L. Gerstenfeld, 2004, Endocrinology.

Monocyte recruitment and expression of monocyte chemoattractant protein-1 are developmentally regulated in remodeling bone in the mouse.

D. Graves, S. Marks, S. Volejnikova, 1997, The American journal of pathology.

Diabetes Enhances Periodontal Bone Loss through Enhanced Resorption and Diminished Bone Formation

D. Graves, N. Krothapalli, Q. Luan, 2006, Journal of dental research.

Role of NOD2 and RIP2 in host–microbe interactions with Gram-negative bacteria: insights from the periodontal disease model

D. Graves, D. Zamboni, L. C. Spolidorio, 2016, Innate immunity.

IMMUNOPATHOLOGY AND INFECTIOUS DISEASES FOXO 1 Deletion Reduces Dendritic Cell Function and Enhances Susceptibility to Periodontitis

D. Graves, Yingying Wu, Yu Wang, 2018 .

Clopidogrel Enhances Mesenchymal Stem Cell Proliferation Following Periodontitis

D. Graves, R. Pignolo, L. C. Spolidorio, 2015, Journal of dental research.

Clopidogrel enhances periodontal repair in rats through decreased inflammation.

D. Graves, L. C. Spolidorio, C. Rossa, 2014, Journal of clinical periodontology.

Locally delivered salicylic acid from a poly(anhydride-ester): impact on diabetic bone regeneration.

J. Fiorellini, D. Graves, K. Uhrich, 2013, Journal of controlled release : official journal of the Controlled Release Society.

A.actinomycetemcomitans-induced periodontal disease promotes systemic and local responses in rat periodontium.

Y. Li, D. Graves, D. Fine, 2012, Journal of clinical periodontology.

Inhibition of Experimental Periodontitis by a Topical Boron-based Antimicrobial

D. Graves, T. Uchihashi, J. Plattner, 2008, Journal of dental research.

Apoptotic Effects of LPS on Fibroblasts are Indirectly Mediated through TNFR1

D. Graves, M. Alikhani, Z. Alikhani, 2004, Journal of dental research.

Inflammation and tissue loss caused by periodontal pathogens is reduced by interleukin-1 antagonists.

D. Graves, S. Amar, A. J. Delima, 2002, The Journal of infectious diseases.

Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing.

D. Graves, S. Kakar, T. Einhorn, 2005, Bone.

Tumor necrosis factor alpha (TNF-α) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing

D. Graves, S. Kakar, T. Einhorn, 2005 .

Contribution of Interleukin-11 and Prostaglandin(s) in Lipopolysaccharide-Induced Bone Resorption In Vivo

D. Graves, S. Amar, L. Shapira, 2002, Infection and Immunity.

Interleukin-1 and Tumor Necrosis Factor Activities Partially Account for Calvarial Bone Resorption Induced by Local Injection of Lipopolysaccharide

D. Graves, S. Amar, C. Chiang, 1999, Infection and Immunity.

NF‐κB Has a Direct Role in Inhibiting Bmp‐ and Wnt‐Induced Matrix Protein Expression

D. Graves, Cun-Yu Wang, Hancheng Guan, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The potential role of chemokines and inflammatory cytokines in periodontal disease progression.

D. Graves, 1999, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Short- and Long-Term Effects of IL-1 and TNF Antagonists on Periodontal Wound Healing1

D. Graves, S. Amar, Xuemei Zhang, 2004, The Journal of Immunology.

Initial characterization of the carbohydrate structure of MCP-1.

A. J. Valente, L. Tabak, D. Graves, 1991, Biochemical and biophysical research communications.

Expression of monocyte chemoattractant protein-1 in delayed type hypersensitivity reactions in the skin.

D. Graves, R. Barnhill, X. Yu, 1994, Laboratory investigation; a journal of technical methods and pathology.

Elevated expression of monocyte chemoattractant protein 1 by vascular smooth muscle cells in hypercholesterolemic primates.

A. J. Valente, G. Sonenshein, D. Graves, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Regulated expression of monocyte chemoattractant protein-1 in normal human osteoblastic cells.

S. Williams, D. Graves, D. Cochran, 1992, American Journal of Physiology.

Purification of a monocyte chemotactic factor secreted by nonhuman primate vascular cells in culture.

A. J. Valente, D. Graves, C. J. Schwartz, 1988, Biochemistry.

Expression of monocyte chemoattractant protein 1 in human osteoblastic cells stimulated by proinflammatory mediators

A. J. Valente, D. Graves, J. Lorenzo, 1994, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Fibroblasts, mononuclear phagocytes, and endothelial cells express monocyte chemoattractant protein-1 (MCP-1) in inflamed human gingiva.

D. Graves, X. Yu, Xiaohui Yu, 1995, Journal of periodontology.

Impact of Diabetes on Fracture Healing

D. Graves, Jazia A. Alblowi, Sheldon S. Lin, 2011 .

Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation.

D. Graves, L. Gerstenfeld, Huafei Lu, 2003, Endocrinology.

Effect of Obesity or Metabolic Syndrome and Diabetes on Osseointegration of Dental Implants in a Miniature Swine Model: A Pilot Study.

B. Pippenger, H. V. van Beusekom, D. Graves, 2018, Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons.

Comparison of Effects of the Bisphosphonate Alendronate Versus the RANKL Inhibitor Denosumab on Murine Fracture Healing

Thomas A Einhorn, Elise F Morgan, Louis C Gerstenfeld, 2009, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Fracture healing as a post‐natal developmental process: Molecular, spatial, and temporal aspects of its regulation

Thomas A Einhorn, Louis C Gerstenfeld, D. Graves, 2003, Journal of cellular biochemistry.

FOXO1 modulates osteoblast differentiation.

E. Moran, D. Graves, M. Siqueira, 2011, Bone.

Interleukin-1 Receptor Signaling Mediates Atherosclerosis Associated With Bacterial Exposure and/or a High-Fat Diet in a Murine Apolipoprotein E Heterozygote Model: Pharmacotherapeutic Implications

R. Levine, E. Messas, D. Graves, 2004, Circulation.

Moloney murine leukemia virus long terminal repeat activates monocyte chemotactic protein‐1 protein expression and chemotactic activity

D. Faller, D. Graves, S. Choi, 1997, Journal of cellular physiology.

Monocyte chemoattractant protein 1 and interleukin-8 production in mononuclear cells stimulated by oral microorganisms

D. Graves, H. Cheng, S. Levitz, 1996, Infection and Immunity.

Cultured primate aortic smooth muscle cells express both the PDGF‐‐A and PDGF‐B genes but do not secrete mitogenic activity or dimeric platelet‐derived growth factor protein

A. J. Valente, D. Graves, C. J. Schwartz, 1988, Journal of cellular physiology.

Cells with osteoblastic phenotypes can be explanted from human gingiva and periodontal ligament.

D. Graves, D. Carnes, C. L. Maeder, 1997, Journal of periodontology.

Interleukin‐1 modulates phosphorylation of proteins in human osteoblastic cells

D. Graves, Yu-Ling Yeh, Yung‐Ming Kang, 1995, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

IFT80 Is Required for Fracture Healing Through Controlling the Regulation of TGF‐β Signaling in Chondrocyte Differentiation and Function

Mohammed A. Alharbi, D. Graves, Shuying Yang, 2020, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Mice Lacking Monocyte Chemoattractant Protein 1 Have Enhanced Susceptibility to an Interstitial Polymicrobial Infection Due to Impaired Monocyte Recruitment

F. C. Gibson, D. Graves, F. Gibson, 2002, Infection and Immunity.

Interleukin-1 Receptor Signaling Rather than That of Tumor Necrosis Factor Is Critical in Protecting the Host from the Severe Consequences of a Polymicrobe Anaerobic Infection

D. Graves, C. Douville, Yanling Jiang, 2000, Infection and Immunity.

Interleukin-1 and tumor necrosis factor receptor signaling is not required for bacteria-induced osteoclastogenesis and bone loss but is essential for protecting the host from a mixed anaerobic infection.

D. Graves, M. Hertzberg, Yanling Jiang, 1999, The American journal of pathology.

Monocyte-Macrophage Participation in Atherogenesis: Inflammatory Components of Pathogenesis

A. J. Valente, D. Graves, M. Rozek, 1986, Seminars in thrombosis and hemostasis.

Osteoclast Formation and Activity FOXO1 Mediates RANKL-Induced

Tian, D. Graves, Yongwon Choi, 2015 .

Clinical, radiographic and biochemical assessment of IL-1/TNF-alpha antagonist inhibition of bone loss in experimental periodontitis.

D. Graves, D. Cochran, T. Oates, 2002, Journal of Clinical Periodontology.

Inflammation-associated lysyl oxidase protein expression in vivo, and modulation by FGF-2 plus IGF-1

D. Graves, D. Carnes, P. Trackman, 1998, Histochemistry and Cell Biology.

Non-canonical Wnt4 prevents skeletal aging and inflammation by inhibiting NF-κB

D. Graves, N. Park, Cun-Yu Wang, 2014, Nature Network Boston.

Wnt 4 signaling prevents skeletal aging and inflammation by inhibiting nuclear factor-B

D. Graves, N. Park, Cun-Yu Wang, 2015 .

Non-canonical Wnt4 prevents skeletal aging and inflammation by inhibiting NF-κB

D. Graves, N. Park, Cun-Yu Wang, 2014, Nature Medicine.

Osteoblast lineage cells and periodontal ligament fibroblasts regulate orthodontic tooth movement that is dependent on Nuclear Factor-kappa B (NF-kB) activation.

D. Graves, M. Shin, H. H. Jeon, 2021, The Angle orthodontist.

The pattern of monocyte recruitment in tumors is modulated by MCP-1 expression and influences the rate of tumor growth.

D. Graves, L. Zhang, H. Cheng, 1997, Laboratory investigation; a journal of technical methods and pathology.

Impact of the host response and osteoblast lineage cells on periodontal disease

D. Graves, Michael Zhou, 2022, Frontiers in Immunology.

Human osteoblasts synthesize and respond to platelet-derived growth factor.

D. Graves, L. Zhang, D. Carnes, 1991, The American journal of physiology.

MCP-1-stimulated monocyte attachment to laminin is mediated by beta 2-integrins.

F. Luscinskas, D. Graves, Y. Jiang, 1994, The American journal of physiology.

The potential role of platelet-derived growth factor as an autocrine or paracrine factor for human bone cells.

A. J. Valente, D. Graves, G. Mundy, 1989, Connective tissue research.

NOD1 in the modulation of host–microbe interactions and inflammatory bone resorption in the periodontal disease model

D. Graves, F. Curylofo-Zotti, D. Zamboni, 2016, Immunology.

PDGF-α Receptor Subunit Expression Down-regulated by IL-1β in Human Periodontal Ligament Cells

D. Graves, D. Cochran, S. Clinton, 1998 .

Pro‐inflammatory cytokines downregulate platelet derived growth factor‐α receptor gene expression in human osteoblastic cells

D. Graves, D. Carnes, Jing-feng Xie, 1996, Journal of cellular physiology.

Receptor binding of PDGF‐AA and PDGF‐BB, and the modulation of PDGF receptors by TGF‐β, in human periodontal ligament cells

D. Graves, D. Cochran, J. Xie, 1995, Journal of cellular physiology.

Effects of platelet-derived growth factor isoforms on calcium release from neonatal mouse calvariae.

D. Graves, D. Cochran, S. Lynch, 1993, Bone.

High-affinity binding of PDGF-AA and PDGF-BB to normal human osteoblastic cells and modulation by interleukin-1.

S. Williams, D. Graves, H. Antoniades, 1991, The American journal of physiology.

The Role of Forkhead Box 1 (FOXO1) in the Immune System: Dendritic Cells, T Cells, B Cells, and Hematopoietic Stem Cells.

D. Graves, C. Rossa, A. A. Cabrera-Ortega, 2017, Critical reviews in immunology.

Targeting the succinate receptor effectively inhibits periodontitis

Xin Li, D. Saxena, D. Graves, 2022, Cell reports.

IL-1 down-regulates platelet-derived growth factor-alpha receptor gene expression at the transcriptional level in human osteoblastic cells.

D. Graves, J. Xie, J. Stroumza, 1994, Journal of Immunology.

Post-translational modification of a monocyte-specific chemoattractant synthesized by glioma, osteosarcoma, and vascular smooth muscle cells.

A. J. Valente, D. Graves, M. J. Williamson, 1990, The Journal of biological chemistry.

Pulse application of platelet‐derived growth factor enhances formation of a mineralizing matrix while continuous application is inhibitory

D. Graves, S. Hsieh, Sung-Chih Hsieh, 1998, Journal of cellular biochemistry.

Quantification and localization of platelet-derived growth factor in gingiva of periodontitis patients.

D. Graves, C. Takiya, E. Feres-Filho, 2003, Journal of periodontology.

Fibroblast apoptosis induced by Porphyromonas gingivalis is stimulated by a gingipain and caspase‐independent pathway that involves apoptosis‐inducing factor

D. Graves, T. Desta, 2007, Cellular microbiology.

FOXO1 Promotes Wound Healing Through the Upregulation of TGF[beta]1 and Prevention of Oxidative Stress

Bhaskar Ponugoti, D. Graves, Fanxing Xu, 2013 .

FOXO1 Regulates Bacteria-Induced Neutrophil Activity

D. Graves, Liang Song, Chanyi Lu, 2017, Front. Immunol..

Fluoxetine treatment increases trabecular bone formation in mice

R. Müller, T. Kohler, D. Graves, 2007, Journal of cellular biochemistry.

Expression of Osteoprotegerin, Receptor Activator of NF‐κB Ligand (Osteoprotegerin Ligand) and Related Proinflammatory Cytokines During Fracture Healing

T A Einhorn, D. Graves, T. Einhorn, 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Developmentally regulated monocyte recruitment and bone resorption are modulated by functional deletion of the monocytic chemoattractant protein-1 gene.

D. Graves, F. Alsulaimani, Y. Ding, 2002, Bone.

Tumor Necrosis Factor Modulates Apoptosis of Monocytes in Areas of Developmentally Regulated Bone Remodeling

D. Graves, S. Volejnikova, S. Marks,, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The expression of monocyte chemoattractant protein-1 and other chemokines by osteoblasts.

A. J. Valente, D. Graves, Yanling Jiang, 1999, Frontiers in bioscience : a journal and virtual library.

Monocyte chemoattractant protein-1 expression and monocyte recruitment in osseous inflammation in the mouse.

C. Y. Wang, D. Graves, Cun-Yu Wang, 1995, Endocrinology.

IL-1 and TNF antagonists inhibit the inflammatory response and bone loss in experimental periodontitis.

D. Graves, D. Cochran, S. Amar, 1998, Journal of immunology.

Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism

D. Graves, R. Pignolo, R. Kayal, 2015, Diabetologia.

Molecular Mechanisms Controlling Bone Formation during Fracture Healing and Distraction Osteogenesis

D. Graves, T. Einhorn, L. Gerstenfeld, 2008, Journal of dental research.

Rapid and long-term effects of PTH(1-34) on growth plate chondrocytes are mediated through two different pathways in a cell-maturation-dependent manner.

D. Graves, B. Boyan, D. Dean, 1997, Bone.

Interaction of oral bacteria with gingival epithelial cell multilayers.

D. Graves, R. Lamont, D. Hagerty, 2011, Molecular oral microbiology.

Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility

D. Graves, C. Rossa, Y. Wu, 2016, Journal of dental research.

Review of osteoimmunology and the host response in endodontic and periodontal lesions

D. Graves, G. Garlet, Gustavo P. Garlet, 2011, Journal of oral microbiology.

Diabetes-enhanced Inflammation and Apoptosis—Impact on Periodontal Pathology

D. Graves, M. Alikhani, P. Trackman, 2006, Journal of dental research.

Chemokines, a family of chemotactic cytokines.

D. Graves, Yanling Jiang, Y. Jiang, 1995, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

FOXO1 Mediates RANKL-Induced Osteoclast Formation and Activity

D. Graves, Yongwon Choi, H. H. Jeon, 2015, The Journal of Immunology.

The use of biologic response modifiers in human clinical trials.

D. Graves, 1997, Annals of periodontology.

Periodontal regeneration with polypeptide growth factors.

D. Graves, D. Cochran, David L. Cochran, 1994, Current opinion in periodontology.

FOXO1 promotes wound healing through the up-regulation of TGF-β1 and prevention of oxidative stress

Bhaskar Ponugoti, D. Graves, Chenying Zhang, 2013, The Journal of cell biology.

P. gingivalis and E. coli lipopolysaccharides exhibit different systemic but similar local induction of inflammatory markers.

D. Graves, R. Darveau, Rongkun Liu, 2008, Journal of periodontology.

Porphyromonas gingivalis and E . coli Lipopolysaccharide Exhibit Different Systemic but Similar Local Induction of Inflammatory Markers

D. Graves, R. Darveau, Rongkun Liu, 2018 .

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D. Graves, D. Cochran, 1990 .

Diabetes and oral disease: implications for health professionals

W. Knowler, P. Papapanou, G. Taylor, 2012, Annals of the New York Academy of Sciences.

The function of dendritic cells in modulating the host response

D. Graves, L. Song, L. Guo, 2018, Molecular oral microbiology.

Oral microbial dysbiosis linked to worsened periodontal condition in rheumatoid arthritis patients

E. Xiao, D. Graves, F. Cunha, 2018, Scientific Reports.

Diabetes Enhances IL-17 Expression and Alters the Oral Microbiome to Increase Its Pathogenicity.

K. Bittinger, D. Graves, Yingying Wu, 2017, Cell host & microbe.

Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status

E. Xiao, D. Graves, E. Leys, 2017, Microbiome.

FOXO Transcription Factors: Their Clinical Significance and Regulation

D. Graves, Yanmin Zhou, Yu Wang, 2014, BioMed research international.

P. gingivalis Modulates Keratinocytes through FOXO Transcription Factors

D. Graves, D. Kinane, M. Benakanakere, 2013, PloS one.

Role of Forkhead Transcription Factors in Diabetes-Induced Oxidative Stress

Bhaskar Ponugoti, D. Graves, G. Dong, 2012, International Journal of Experimental Diabetes Research.

FOXO1 Plays an Important Role in Enhanced Microvascular Cell Apoptosis and Microvascular Cell Loss in Type 1 and Type 2 Diabetic Rats

D. Graves, Sayon Roy, Y. Behl, 2009, Diabetes.

FOXO1 Plays an Important Role in Enhanced Microvascular Cell Apoptosis and Microvascular Cell Loss in Type 1 and Type 2 Diabetic Rats

D. Graves, Sayon Roy, Y. Behl, 2009, Diabetes.

Diabetes mellitus related bone metabolism and periodontal disease

E. Xiao, D. Graves, Yingying Wu, 2015, International Journal of Oral Science.

Tumor Necrosis Factor Modulates Fibroblast Apoptosis, PMN Recruitment, and Osteoclast Formation in Response to P. gingivalis Infection

D. Graves, G. Naguib, Y. Jiang, 2001, Journal of dental research.

Periodontal pathogens stimulate CC-chemokine production by mononuclear and bone-derived cells.

D. Graves, Y. Jiang, 1999, Journal of periodontology.

Bacterial infection increases periodontal bone loss in diabetic rats through enhanced apoptosis.

D. Graves, D. Fine, Jun Kang, 2013, The American journal of pathology.

FOXO1 Deletion Reverses the Effect of Diabetic-Induced Impaired Fracture Healing

Mohammed A. Alharbi, Hongli Jiao, D. Graves, 2018, Diabetes.

Lipid peroxidation is associated with the severity of periodontal disease and local inflammatory markers in patients with type 2 diabetes.

D. Graves, C. Rossa Junior, A. Bastos, 2012, Journal of Clinical Endocrinology and Metabolism.

NF-κB perturbation reveals unique immunomodulatory functions in Prx1+ fibroblasts that promote development of atopic dermatitis

D. Graves, F. Alawi, S. Millar, 2022, Science Translational Medicine.

Monocyte chemoattractant protein-1 induces monocyte recruitment that is associated with an increase in numbers of osteoblasts.

D. Graves, D. Carnes, L. Posner, 1997, Bone.

Protein-1 Gene Transcription -Stimulated Monocyte Chemoattractant γ A Complex Element Regulates IFN-

A. J. Valente, D. Graves, H. Abboud, 2013 .

A complex element regulates IFN-gamma-stimulated monocyte chemoattractant protein-1 gene transcription.

A. J. Valente, D. Graves, H. Abboud, 1998, Journal of immunology.

Expression of monocyte chemotactic protein-1 in human melanoma in vivo.

D. Graves, H. Antoniades, T. Galanopoulos, 1992, The American journal of pathology.

Effect of Bacteria on the Wound Healing Behavior of Oral Epithelial Cells

Bhaskar Ponugoti, D. Graves, Fanxing Xu, 2014, PloS one.

FOXO1 differentially regulates both normal and diabetic wound healing

Bhaskar Ponugoti, D. Graves, Chenying Zhang, 2015, The Journal of cell biology.

Evidence that diabetes mellitus aggravates periodontal diseases and modifies the response to an oral pathogen in animal models.

D. Graves, Rongkun Liu, H. Al-Mashat, 2004, Compendium of continuing education in dentistry.

FOXO1, TGF-β Regulation and Wound Healing

D. Graves, Gabrielle S. Graves, Angelika Batres, 2014, International journal of molecular sciences.

Biologically active mediators: platelet-derived growth factor, monocyte chemoattractant protein-1, and transforming growth factor-beta.

D. Graves, D. Cochran, 1991, Current opinion in dentistry.

Lipopolysaccharides Indirectly Stimulate Apoptosis and Global Induction of Apoptotic Genes in Fibroblasts*

D. Graves, M. Alikhani, Z. Alikhani, 2003, Journal of Biological Chemistry.

Characterization of monocyte chemotactic protein-1 binding to human monocytes.

A. J. Valente, D. Graves, M. Rozek, 1991, Biochemical and biophysical research communications.

Diabetic complications and dysregulated innate immunity.

D. Graves, R. Kayal, 2008, Frontiers in bioscience : a journal and virtual library.

FOXO1 Regulates Dendritic Cell Activity through ICAM-1 and CCR7

D. Graves, Fanxing Xu, Yongwon Choi, 2015, The Journal of Immunology.

Diabetes-enhanced inflammation and apoptosis: impact on periodontal pathosis.

D. Graves, T. Oates, Rongkun Liu, 2007, Periodontology 2000.

Monocyte chemotactic proteins from human tumor cells.

A. J. Valente, D. Graves, A. Valente, 1991, Biochemical pharmacology.

Expression of monocyte chemoattractant protein 1 in human inflamed gingival tissues

D. Graves, H. Antoniades, X. Yu, 1993, Infection and immunity.

The transcription factor ST18 regulates proapoptotic and proinflammatory gene expression in fibroblasts

D. Graves, M. Siqueira, M. Alikhani, 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Oral mucosal breaks trigger anti-citrullinated bacterial and human protein antibody responses in rheumatoid arthritis

Austin D. Swafford, O. Troyanskaya, J. Fak, 2023, Science Translational Medicine.

Diabetes-Induced NF-κB Dysregulation in Skeletal Stem Cells Prevents Resolution of Inflammation

D. Graves, Kang I Ko, Chider Chen, 2019, Diabetes.

Osteoblast Lineage Cells Play an Essential Role in Periodontal Bone Loss Through Activation of Nuclear Factor-Kappa B

D. Graves, Cun-Yu Wang, Bo Yu, 2015, Scientific Reports.

Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption.

T A Einhorn, D. Graves, T. Einhorn, 2003, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Diabetes Impairs Fracture Healing Through Disruption Of Cilia Formation In Osteoblasts.

D. Graves, Shuying Yang, Min Liu, 2021, Bone.

Diabetic Wound Healing in Soft and Hard Oral Tissues.

D. Graves, A. Sculean, Kang I Ko, 2021, Translational research : the journal of laboratory and clinical medicine.

TNFα contributes to diabetes impaired angiogenesis in fracture healing.

D. Graves, R. Kayal, T. Einhorn, 2017, Bone.

Gene Expression Dynamics during Diabetic Periodontitis

D. Graves, F. Alawi, J. Galicia, 2012, Journal of dental research.

Diabetes aggravates periodontitis by limiting repair through enhanced inflammation

D. Graves, F. Alawi, H. Patel, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Aggregatibacter actinomycetemcomitans Infection Enhances Apoptosis In Vivo through a Caspase-3-Dependent Mechanism in Experimental Periodontitis

Y. Li, D. Graves, D. Fine, 2012, Infection and Immunity.

Diabetes and increased lipid peroxidation are associated with systemic inflammation even in well-controlled patients.

N. Câmara, D. Graves, S. C. T. Corbi, 2016, Journal of diabetes and its complications.

High levels of tumor necrosis factor-alpha contribute to accelerated loss of cartilage in diabetic fracture healing.

Thomas A Einhorn, Jody McLean, D. Graves, 2009, The American journal of pathology.

Advanced Glycation End Products Enhance Expression of Pro-apoptotic Genes and Stimulate Fibroblast Apoptosis through Cytoplasmic and Mitochondrial Pathways*

D. Graves, M. Alikhani, Z. Alikhani, 2005, Journal of Biological Chemistry.

Cytokine Profiling of Macrophages Exposed to Porphyromonas gingivalis, Its Lipopolysaccharide, or Its FimA Protein

D. Graves, S. Amar, M. Fenton, 2005, Infection and Immunity.

Cellular and Molecular Aspects of Bone Remodeling.

Yu Wang, D. Graves, Dana T Graves, 2016, Frontiers of oral biology.

Role of Fas and Treg Cells in Fracture Healing as Characterized in the Fas-Deficient (lpr) Mouse Model of Lupus†

D. Graves, S. Kakar, T. Einhorn, 2014, Journal of Bone and Mineral Research.

Depletion of the diabetic gut microbiota resistance enhances stem cells therapy in type 1 diabetes mellitus

D. Graves, Yan Shi, Xuliang Deng, 2020, Theranostics.

Establishment of oral bacterial communities in germ‐free mice and the influence of recipient age

D. Graves, C. Westwater, W. Xiao, 2018, Molecular oral microbiology.

Impact of Diabetes on Periodontal Disease

E. Xiao, D. Graves, Yingying Wu, 2016 .

Keratinocyte Function in Normal and Diabetic Wounds and Modulation by FOXO1

D. Graves, Yulan Wang, 2020, Journal of diabetes research.

Endodontic pathogens stimulate monocyte chemoattractant protein-1 and interleukin-8 in mononuclear cells.

D. Graves, H. Schilder, Y. Jiang, 1998, Journal of endodontics.

Deletion of FOXO1 in chondrocytes rescues the effect of diabetes on mechanical strength in fracture healing.

Mohammed A. Alharbi, D. Graves, Yongjian Lu, 2019, Bone.

Salicylic Acid Polymers in Periodontal Tissue Healing

Yue Cao, D. Graves, P. Coelho, 2020 .

Mechanical Regulation of Oral Epithelial Barrier Function

D. Graves, Yoontaek Kim, Anthony P. Kotula, 2023, Bioengineering.

Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment.

Thomas A Einhorn, D. Graves, R. Kayal, 2009, Bone.

Osteoimmunology in Periodontitis and Orthodontic Tooth Movement

D. Graves, J. Ni, H. H. Jeon, 2023, Current Osteoporosis Reports.

FOXO1 differentially regulates both normal and diabetic wound healing

Bhaskar Ponugoti, D. Graves, Chenying Zhang, 2015, Journal of Cell Biology.

FOXO1 differentially regulates both normal and diabetic wound healing

Bhaskar Ponugoti, D. Graves, Chenying Zhang, 2015, The Journal of cell biology.

Chondrocytes Promote Vascularization in Fracture Healing Through a FOXO1‐Dependent Mechanism

Mohammed A. Alharbi, D. Graves, Chanyi Lu, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Temporal expression of PDGF receptors and PDGF regulatory effects on osteoblastic cells in mineralizing cultures.

D. Graves, S. Hsieh, X. Yu, 1997, The American journal of physiology.

Advanced glycation end products induce apoptosis in fibroblasts through activation of ROS, MAP kinases, and the FOXO1 transcription factor.

D. Graves, M. Alikhani, P. Trackman, 2007, American journal of physiology. Cell physiology.

The Interrelationship Between Diabetes, IL-17 and Bone Loss

D. Graves, X. Pei, Zhen Huang, 2020, Current Osteoporosis Reports.

Spinal cord injury causes rapid osteoclastic resorption and growth plate abnormalities in growing rats (SCI-induced bone loss in growing rats)

R. Müller, T. Kohler, D. Graves, 2008, Osteoporosis International.

MCP-1-stimulated monocytes preferentially utilize beta 2-integrins to migrate on laminin and fibronectin.

F. Luscinskas, D. Graves, Y. Jiang, 1995, The American journal of physiology.

Osteocytes play an important role in experimental periodontitis in healthy and diabetic mice through expression of RANKL

D. Graves, J. D. Corrêa, Yang Yang, 2018, Journal of clinical periodontology.

Role of Primary Cilia in Bone and Cartilage

D. Graves, S. Yang, Z. Chinipardaz, 2021, Journal of dental research.

IL-1 and transforming growth factor-beta inhibit platelet-derived growth factor-AA binding to osteoblastic cells by reducing platelet-derived growth factor-alpha receptor expression.

D. Graves, Y. Yeh, M. Chaibi, 1993, Journal of immunology.

Leukocyte adhesion molecules.

D. Graves, Yanling Jiang, Y. Jiang, 1997, Critical reviews in oral biology and medicine : an official publication of the American Association of Oral Biologists.

FOXO1 expression in chondrocytes modulates cartilage production and removal in fracture healing.

Mohammed A. Alharbi, Hongli Jiao, D. Graves, 2021, Bone.

Effects of local insulin delivery on subperiosteal angiogenesis and mineralized tissue formation during fracture healing

D. Graves, J. Benevenia, Sheldon S. Lin, 2013, Journal of Orthopaedic Research.

Distinct fibroblast progenitor subpopulation expedites regenerative mucosal healing by immunomodulation

D. Graves, Rahul Debnath, J. Korostoff, 2022, The Journal of experimental medicine.

The Oral Microbiota Is Modified by Systemic Diseases

D. Graves, J. D. Corrêa, T. Silva, 2018, Journal of dental research.

FOXO 1 deletion in chondrocytes rescues diabetes-impaired fracture healing by restoring angiogenesis and reducing apoptosis

Mohammed A. Alharbi, D. Graves, 2023, Frontiers in endocrinology.

Interleukin-1 and Tumor Necrosis Factor Activities Partially Account for Calvarial Bone Resorption Induced by Local Injection of Lipopolysaccharide

D. Graves, S. Amar, C. Chiang, 1999, Infection and Immunity.