P. Krogsgaard‐Larsen

发表

P. Krogsgaard‐Larsen, E. Falch, 1981, Molecular and Cellular Biochemistry.

Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs.

A. Schousboe, P. Krogsgaard‐Larsen, P. Wellendorph, 2017, Advances in neurobiology.

Synthesis and in vitro pharmacology at AMPA and kainate preferring glutamate receptors of 4-heteroarylmethylidene glutamate analogues.

P. Krogsgaard‐Larsen, A. Kristensen, D. Pickering, 2003, Bioorganic & medicinal chemistry.

Stereochemistry and molecular pharmacology of (S)-thio-ATPA, a new potent and selective GluR5 agonist.

P. Krogsgaard‐Larsen, K. Frydenvang, J. Egebjerg, 2001, European journal of pharmacology.

Structural Determinants for AMPA Agonist Activity of Aryl or Heteroaryl Substituted AMPA Analogues. Synthesis and Pharmacology

U. Sørensen, P. Krogsgaard‐Larsen, E. Falch, 2001, Archiv der Pharmazie.

Aryl and cycloalkyl analogues of AMPA: synthetic, pharmacological and stereochemical aspects.

P. Krogsgaard‐Larsen, E. Falch, B. Ebert, 1998, Bioorganic & medicinal chemistry.

Excitatory amino-acid receptor agonists. Synthesis and pharmacology of analogues of 2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1997 .

Excitatory amino acid receptor antagonists: resolution, absolute stereochemistry, and pharmacology of (S)- and (R)-2-amino-2-(5-tert-butyl-3-hydroxyisoxazol-4-yl)acetic acid (ATAA).

P. Krogsgaard‐Larsen, K. Frydenvang, U. Madsen, 1997, Chirality.

Bioisosterically modified dipeptide excitatory amino acid receptor antagonists containing 3-oxygenated isothiazole ring systems.

P. Krogsgaard‐Larsen, J. Jaroszewski, B. Frølund, 1997, Bioorganic & medicinal chemistry.

Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.

P. Krogsgaard‐Larsen, B. Bang-Andersen, U. Madsen, 1996, Journal of medicinal chemistry.

Excitatory amino acids. Synthesis of (RS)-2-amino-3-(5-cyclopropyl-3-hydroxyisoxazol-4-yl)propionic acid, a new potent and specific AMPA receptor agonist

P. Krogsgaard‐Larsen, E. Falch, B. Ebert, 1995 .

The non-depolarizing D-form of bromohomoibotenic acid enhances depolarizations evoked by the L-form or quisqualate.

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1993, European journal of pharmacology.

Excitatory amino acid receptor atagonists: synthesis and pharmacology of 3-(carboxymethoxy)isoxazoles derived from AMPA

P. Krogsgaard‐Larsen, T. B. Rasmussen, U. Madsen, 1993 .

Enzymatic resolution of AMPA by use of α-chymotrypsin

D. R. Curtis, P. Krogsgaard‐Larsen, U. Madsen, 1993 .

Synthesis and pharmacology of (RS)-2-amino-3-(3-hydroxy-5-trifluoromethyl-4-isoxazolyl)propionic acid, a potent AMPA receptor agonist

E. Wong, P. Krogsgaard‐Larsen, U. Madsen, 1992 .

Differential effects of nipecotic acid and 4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol on extracellular gamma-aminobutyrate levels in rat thalamus.

K. Kekesi, G. Juhász, A. Schousboe, 1997, European journal of pharmacology.

GABA uptake inhibitors: Possible use as anti-epileptic drugs

A. Schousboe, P. Krogsgaard‐Larsen, R. Harbaugh, 1990 .

Anticonvulsant activity of intracerebroventricularly administered glial GABA uptake inhibitors and other GABAmimetics in chemical seizure models

A. Schousboe, P. Krogsgaard‐Larsen, R. Harbaugh, 1989, Epilepsy Research.

GABA uptake inhibitors: relevance to antiepileptic drug research

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1987, Epilepsy Research.

Lack of a high affinity uptake system for the GABA agonists THIP and isoguvacine in neurons and astrocytes cultured from mouse brain

A. Schousboe, P. Krogsgaard‐Larsen, O. Larsson, 1985, Neurochemistry International.

Transport and Metabolism of 7‐Aminobutyric Acid in Neurons and Glia: Implications for Epilepsy

A. Schousboe, P. Krogsgaard‐Larsen, J. Wood, 1983, Epilepsia.

Binding sites for the glutamate-analogue [3H]AMPA in cultured rat brainstem and spinal cord

P. Krogsgaard‐Larsen, L. Hösli, E. Hösli, 1983, Brain Research.

Heterocyclic GABA analogues as new selective inhibitors of astroglial GABA transport

A. Schousboe, P. Krogsgaard‐Larsen, L. Hertz, 1981 .

Interactions between conformationally restricted GABA analogues and the astroglial GABA carrier

A. Schousboe, P. Krogsgaard‐Larsen, L. Hertz, 1980, Brain Research Bulletin.

Inhibition of the high-affinity, net uptake of GABA into cultured astrocytes by β-proline, nipecotic acid and other compounds

A. Schousboe, P. Krogsgaard‐Larsen, L. Hertz, 1978, Brain Research.

GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.

T. Liljefors, P. Krogsgaard‐Larsen, B. Frølund, 2006, Advances in pharmacology.

Specific GABA(A) agonists and partial agonists.

T. Liljefors, P. Krogsgaard‐Larsen, B. Frølund, 2002, Chemical record.

The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8-methyl analogue: synthesis, molecular pharmacology, and biostructural characterization.

Peter Naur, Hans Bräuner-Osborne, P. Naur, 2009, Journal of medicinal chemistry.

Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design

P. Krogsgaard‐Larsen, L. Bunch, 2009, Medicinal research reviews.

GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects.

P. Krogsgaard‐Larsen, B. Frølund, K. Frydenvang, 2000, Current pharmaceutical design.

GABAA receptor partial agonists and antagonists: structure, binding mode, and pharmacology.

U. Kristiansen, P. Krogsgaard‐Larsen, B. Frølund, 2015, Advances in pharmacology.

Effects of barbiturates on astrocytes

A. Schousboe, B. R. Sastry, P. Krogsgaard‐Larsen, 1979, Brain Research Bulletin.

Probing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres

P. Krogsgaard‐Larsen, B. Frølund, R. Bergmann, 2013, Neurochemical Research.

GABAB antagonists: resolution, absolute stereochemistry, and pharmacology of (R)- and (S)-phaclofen.

P. Krogsgaard‐Larsen, K. Frydenvang, G. Johnston, 1994, Chirality.

Sequence and expression pattern of a novel human orphan G-protein-coupled receptor, GPRC5B, a family C receptor with a short amino-terminal domain.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, P Krogsgaard-Larsen, 2000, Genomics.

Pharmacological characterization of homobaclofen on wild type and mutant GABA(B)1b receptors coexpressed with the GABA(B)2 receptor.

P. Krogsgaard‐Larsen, A. A. Jensen, H. Bräuner‐Osborne, 2001, European journal of pharmacology.

Synthesis and pharmacology of the baclofen homologues 5-amino-4-(4-chlorophenyl)pentanoic acid and the R- and S-enantiomers of 5-amino-3-(4-chlorophenyl)pentanoic acid.

P. Krogsgaard‐Larsen, B. Ebert, B. Nielsen, 1999, Journal of medicinal chemistry.

Pharmacological profile of gamma-aminobutyric acid (GABA) receptors of identified central neurones from Helix Aspersa

P. Krogsgaard‐Larsen, R. Walker, Á. Vehovszky, 1989 .

Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties.

D. Gloriam, P. Krogsgaard‐Larsen, A. A. Jensen, 2013, Journal of medicinal chemistry.

5-Substituted imidazole-4-acetic acid analogues: synthesis, modeling, and pharmacological characterization of a series of novel gamma-aminobutyric acid(C) receptor agonists.

T. Liljefors, U. Kristiansen, P. Krogsgaard‐Larsen, 2007, Journal of Medicinal Chemistry.

A novel route to 5-substituted 3-isoxazolols. Cyclization of N, O-DiBoc beta-keto hydroxamic acids synthesized via acyl Meldrum's acids.

U. Sørensen, P. Krogsgaard‐Larsen, E. Falch, 2000, The Journal of organic chemistry.

Synthesis and muscarinic receptor pharmacology of a series of 4,5,6,7-tetrahydroisothiazolo[4,5-c]pyridine bioisosteres of arecoline.

K. Bogeso, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 1999, Bioorganic & medicinal chemistry.

GABAB antagonists: Enantiopharmacology of 5‐amino‐4‐hydroxy‐2‐methylvaleric acid and X‐ray structure of the eutomer

U. Kristiansen, P. Krogsgaard‐Larsen, B. Frølund, 1995 .

Solid-phase synthesis and pharmacological evaluation of analogues of PhTX-12-A potent and selective nicotinic acetylcholine receptor antagonist.

P. Usherwood, P. Krogsgaard‐Larsen, J. Jaroszewski, 2002, Bioorganic & medicinal chemistry letters.

ACID CATALYZED DEHYDRATION OF ALDITOLS. PART I. D-GLUCITOL AND D-MANNITOL

P. Krogsgaard‐Larsen, H. Thøgersen, K. Bock, 1982 .

Novel 5-substituted 1-pyrazolol analogues of ibotenic acid: synthesis and pharmacology at glutamate receptors.

J. Kehler, P. Krogsgaard‐Larsen, R. Clausen, 2007, Bioorganic & medicinal chemistry.

Resolution, absolute stereochemistry, and pharmacology of the S-(+)- and R-(-)-isomers of the apparent partial AMPA receptor agonist (R,S)-2-amino-3-(3-hydroxy-5-phenylisoxazol-4-yl)propionic acid [(R,S)-APPA].

K. Bogeso, P. Krogsgaard‐Larsen, B. Ebert, 1994, Journal of medicinal chemistry.

Ibotenic acid analogues. Synthesis and biological and in vitro activity of conformationally restricted agonists at central excitatory amino acid receptors.

D. R. Curtis, P. Krogsgaard‐Larsen, E. Nielsen, 1984, Journal of medicinal chemistry.

(S)-2-Amino-3-(3-hydroxy-7,8-dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid, a potent and selective agonist at the GluR5 subtype of ionotropic glutamate receptors. Synthesis, modeling, and molecular pharmacology.

J. Greenwood, P. Krogsgaard‐Larsen, K. Hansen, 2003, Journal of medicinal chemistry.

Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.

J. Greenwood, P. Krogsgaard‐Larsen, R. Clausen, 2005, Journal of medicinal chemistry.

Ligands for Glutamate Receptors: Design and Therapeutic Prospects

P. Krogsgaard‐Larsen, U. Madsen, J. Egebjerg, 2000 .

Muscarinic agonists. Syntheses and structure-activity relationships of bicyclic isoxazole ester bioisosteres of norarecoline

K. Bogeso, P. Krogsgaard‐Larsen, H. Pedersen, 1995 .

The Molecular Structure of trans-Cyclooctene.

G. Schroll, C. Romming, P. Krogsgaard‐Larsen, 1975 .

Hydrogen bonds in the structure of BaC2C4.D2O

P. Krogsgaard‐Larsen, L. Niinistö, J. Sandström, 1992 .

Bioisosteric determinants for subtype selectivity of ligands for heteromeric GABA(A) receptors.

J. Kehler, P. Krogsgaard‐Larsen, M. Mortensen, 2001, Bioorganic & medicinal chemistry letters.

Betel nut constituents as inhibitors of gamma-aminobutyric acid uptake.

P. Krogsgaard‐Larsen, G. Johnston, A. Stephanson, 1975, Nature.

Recent advances in the medicinal chemistry of polyamine toxins.

P. Krogsgaard‐Larsen, J. Jaroszewski, K. Strømgaard, 2001, Mini reviews in medicinal chemistry.

GABA‐Mimetic Activity and Effects on Diazepam Binding of Aminosulphonic Acids Structurally Related to Piperidine‐4‐Sulphonic Acid

D. R. Curtis, P. Krogsgaard‐Larsen, E. Falch, 1985, Journal of neurochemistry.

The role of Arg(78) in the metabotropic glutamate receptor mGlu(1) for agonist binding and selectivity.

P. O'Hara, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 2000, European journal of pharmacology.

Synthesis and pharmacology of glutamate receptor ligands: new isothiazole analogues of ibotenic acid.

J. Kehler, P. Krogsgaard‐Larsen, K. Hansen, 2007, Organic & biomolecular chemistry.

Estimation of Reduction and Standard Potentials of Some Allyl and Substituted Alkyl Radicals.

P. Krogsgaard‐Larsen, K. Daasbjerg, J. Sandström, 1992 .

Direct oxidative cyanation of dibenzofuran

F. Radner, P. Krogsgaard‐Larsen, H. Siegbahn, 1992 .

Structure-activity relationship and pharmacology of gamma-aminobutyric acid (GABA) transport inhibitors.

A. Schousboe, P. Krogsgaard‐Larsen, B. Frølund, 2006, Advances in pharmacology.

GABA(A) receptor ligands and their therapeutic potentials.

T. Liljefors, U. Kristiansen, P. Krogsgaard‐Larsen, 2002, Current topics in medicinal chemistry.

A new highly selective metabotropic excitatory amino acid agonist: 2-amino-4-(3-hydroxy-5-methylisoxazol-4-yl)butyric acid.

S. Nakanishi, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 1996, Journal of medicinal chemistry.

Synthesis and biological activity of a GABAA agonist which has no effect on benzodiazepine binding and of structurally related glycine antagonists.

D. R. Curtis, P. Krogsgaard‐Larsen, E. Falch, 1987, Drug design and delivery.

Characterization of the Binding of the GABA Agonist [3H]Piperidine‐4‐Sulphonic Acid to Bovine Brain Synaptic Membranes

A. Snowman, R. Olsen, P. Krogsgaard‐Larsen, 1981, Journal of neurochemistry.

Studies on the action of GABA, muscimol and related compounds on Periplaneta and Limulus central neurons

P. Krogsgaard‐Larsen, R. Walker, C. Roberts, 1981 .

Functional Importance of the Ala116–Pro136 Region in the Calcium-sensing Receptor

M. Brann, P. O'Hara, P. Krogsgaard‐Larsen, 2000, The Journal of Biological Chemistry.

A new structural class of subtype-selective inhibitor of cloned excitatory amino acid transporter, EAAT2.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, B. Nielsen, 2000, European journal of pharmacology.

Characterization of a new AMPA receptor radioligand, [3H]2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid.

P. Krogsgaard‐Larsen, N. Diemer, U. Madsen, 1999, European journal of pharmacology.

Structural features of muscimol, a potent GABAA receptor agonist, crystal structure and quantum chemicalab initio calculations

T. Liljefors, P. Krogsgaard‐Larsen, P. Norrby, 1997 .

(−)‐(R)‐5,5‐Dimethylmorpholinyl‐2‐acetic Acid Ethyl Ester Hydrochloride, C10H20NO3+.Cl−

P. Krogsgaard‐Larsen, K. Frydenvang, S. Enna, 1997 .

Structure and pharmacology of 4,5,6,7-tetrahydroisothiazolo[5,4-c]pyridin-3-ol (Thio-THIP), an agonist/antagonist at GABAA receptors

J. Kemp, U. Kristiansen, P. Krogsgaard‐Larsen, 1997 .

Amplification by glycine of the anticonvulsant effect of THPO, a GABA uptake inhibitor.

A. Schousboe, P. Krogsgaard‐Larsen, N. Seiler, 1985, General pharmacology.

Differentiation of in vivo effects of AMPA and NMDA receptor ligands using drug discrimination methods and convulsant/anticonvulsant activity.

P. Krogsgaard‐Larsen, C. Sánchez, J. Arnt, 1995, European journal of pharmacology.

GABAA receptor agonists, partial agonists, and antagonists. Design and therapeutic prospects.

A. Schousboe, P. Krogsgaard‐Larsen, F. Jørgensen, 1994, Journal of medicinal chemistry.

Medicinal Chemistry of α‐Amino Acids

P. Krogsgaard‐Larsen, L. Bunch, 2011 .

Subtype selective kainic acid receptor agonists: Discovery and approaches to rational design

P. Krogsgaard‐Larsen, L. Bunch, 2009, Medicinal research reviews.

Effect of Homo‐β‐Proline and Other Heterocyclic GAB A Analogues on GABA Uptake in Neurons and Astroglial Cells and on GABA Receptor Binding

A. Schousboe, P. Krogsgaard‐Larsen, O. Larsson, 1981, Journal of neurochemistry.

Tissue Distribution, Metabolism, Anticonvulsant Efficacy, and Effect on Brain Amino Acid Levels of the Glia‐Selective γ‐Aminobutyric Acid Transport Inhibitor 4,5,6,7‐Tetrahydroisoxazolo[4,5‐c]pyridin‐3‐ol in Mice and Chicks

A. Schousboe, P. Krogsgaard‐Larsen, J. Wood, 1986, Journal of neurochemistry.

Variations in the kinetic pattern of astrocytic gamma-aminobutyric acid uptake when inhibited by different barbiturates.

A. Schousboe, P. Krogsgaard‐Larsen, L. Hertz, 1982, Biochemical pharmacology.

GABA receptor agonists: relationship between structure and biological activity in vivo and in vitro.

P. Krogsgaard‐Larsen, J. Arnt, 1979, Advances in experimental medicine and biology.

Effects of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazol (exo-THPO) and its N-substituted analogs on GABA transport in cultured neurons and astrocytes and by the four cloned mouse GABA transporters

A. Schousboe, P. Krogsgaard‐Larsen, B. Frølund, 2003, Neurochemistry International.

Inhibitors of gamma-aminobutyric acid transport as experimental tools and therapeutic agents.

P. Krogsgaard‐Larsen, E. Falch, B. Frølund, 1998, Methods in enzymology.

gamma-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects.

P. Krogsgaard‐Larsen, 1981, Journal of medicinal chemistry.

SYNTHESIS AND SYNTHETIC UTILITY OF 3-ISOXAZOLOLS

U. Sørensen, P. Krogsgaard‐Larsen, 2001 .

Comparative stereostructure-activity studies on GABAA and GABAB receptor sites and GABA uptake using rat brain membrane preparations.

P. Krogsgaard‐Larsen, E. Falch, H. Hjeds, 2006, Journal of neurochemistry.

Selective inhibitors of glial GABA uptake: synthesis, absolute stereochemistry, and pharmacology of the enantiomers of 3-hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole (exo-THPO) and analogues.

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1999, Journal of medicinal chemistry.

Kinetic Characterization of Inhibition of γ‐Aminobutyric Acid Uptake into Cultured Neurons and Astrocytes by 4,4‐Diphenyl‐3‐Butenyl Derivatives of Nipecotic Acid and Guvacine

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1988, Journal of neurochemistry.

Glycine Antagonists Structurally Related to 4,5,6,7‐Tetrahydroisoxazolo[5,4‐c]pyridin‐3‐ol Inhibit Binding of [3H]Strychnine to Rat Brain Membranes

P. Krogsgaard‐Larsen, C. Braestrup, M. Nielsen, 1986, Journal of neurochemistry.

Contrasting actions of philanthotoxin-343 and philanthotoxin-(12) on human muscle nicotinic acetylcholine receptors.

P. Usherwood, P. Krogsgaard‐Larsen, J. Jaroszewski, 2003, Molecular pharmacology.

Stereoselective effects of AMOA on non‐NMDA receptors expressed in Xenopus Oocytes

R. Miledi, A. Schousboe, P. Krogsgaard‐Larsen, 1992, Journal of neuroscience research.

GABA and Glutamate Receptor Ligands and their Therapeutic Potential in CNS Disorders

T. Liljefors, J. Greenwood, P. Krogsgaard‐Larsen, 2010 .

New synthesis of 3-chloroisoxazoles

G. Schlewer, P. Krogsgaard‐Larsen, 1985 .

Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.

K. Bogeso, P. Krogsgaard‐Larsen, B. Bang-Andersen, 1997, Journal of medicinal chemistry.

The role of carbon monosulfide in the electrochemical preparation of 4,5-bis(methylthio)-1,3-dithiole-2-thione

R. Ryhage, P. Krogsgaard‐Larsen, R. Isaksson, 1986 .

Ligands for the GABAA receptor complex

U. Kristiansen, P. Krogsgaard‐Larsen, B. Frølund, 2001 .

GABAA and GABAB receptor agonists, partial agonists, antagonists and modulators: design and therapeutic prospects

U. Kristiansen, P. Krogsgaard‐Larsen, K. Frydenvang, 1997 .

GABAA Receptor Agonists, Partial Agonists, and Antagonists

P. Krogsgaard‐Larsen, B. Frølund, B. Ebert, 1997 .

Role of GABAA and GABAB Receptors in Ca++ Homeostasis and Transmitter Release in Cerebellar Granule Neurons

A. Schousboe, P. Krogsgaard‐Larsen, J. Kardos, 1996 .

Ketobemidone, methadone and pethidine are non-competitive N-methyl-d-aspartate (NMDA) antagonists in the rat cortex and spinal cord

P. Krogsgaard‐Larsen, B. Ebert, S. Andersen, 1995, Neuroscience Letters.

Kainic acid neurotoxicity: in vivo test of two new non-N-methyl-d-aspartate receptor antagonists

P. Krogsgaard‐Larsen, N. Diemer, F. Johansen, 2004, Acta Neuropathologica.

Role of GABAB receptors in intracellular Ca2+ homeostasis and possible interaction between GABAA and GABAB receptors in regulation of transmitter release in cerebellar granule neurons

A. Schousboe, P. Krogsgaard‐Larsen, J. Kardos, 1994, Journal of neuroscience research.

A new class of GABA agonist

D. R. Curtis, P. Krogsgaard‐Larsen, D. Lodge, 1977, Nature.

DIHYDROMUSCIMOL, THIOMUSCIMOL AND RELATED HETEROCYCLIC COMPOUNDS AS GABA ANALOGUES

D. R. Curtis, P. Krogsgaard‐Larsen, D. Lodge, 1979, Journal of neurochemistry.

Dual y-Aminobutyric Acid Control of Prolactin Secretion in the Rat*

D. Cocchi, P. Krogsgaard‐Larsen, V. Locatelli, 1979 .

Prolactin-inhibiting activity of gamma-aminobutyric acid-mimetic drugs in the male rat

D. Cocchi, P. Krogsgaard‐Larsen, V. Locatelli, 1978, Brain Research.

Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study Part I: Brain glucose metabolism is increased after GABAA receptors activation

F. Mauguière, R. Peyron, L. Garcia-Larrea, 1994, Epilepsy Research.

Recent Advances in GABA Agonists, Antagonists and Uptake Inhibitors: Structure–Activity Relationships and Therapeutic Potential

P. Krogsgaard‐Larsen, E. Falch, F. Jørgensen, 1988 .

Heterocyclic analogues of GABA: chemistry, molecular pharmacology and therapeutic aspects.

P. Krogsgaard‐Larsen, E. Falch, H. Hjeds, 1985, Progress in medicinal chemistry.

Stereostructure-activity studies on agonists at the AMPA and kainate subtypes of ionotropic glutamate receptors.

J. Greenwood, P. Krogsgaard‐Larsen, K. Frydenvang, 2003, Chirality.

GABA synaptic mechanisms: Stereochemical and conformational requirements

P. Krogsgaard‐Larsen, 1988, Medicinal research reviews.

Structural, conformational, and stereochemical requirements of central excitatory amino acid receptors

P. Krogsgaard‐Larsen, J. J. Hansen, 1990, Medicinal research reviews.

γ‐Aminobutyric Acid and Glycine Neurotransmitter Transporters

G. Ecker, A. Schousboe, P. Krogsgaard‐Larsen, 2017 .

Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization.

Arne Schousboe, A. Schousboe, P. Krogsgaard‐Larsen, 2013, Journal of medicinal chemistry.

Synaptic and extrasynaptic GABA transporters as targets for anti‐epileptic drugs

A. Schousboe, P. Krogsgaard‐Larsen, R. Clausen, 2009, Journal of neurochemistry.

Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues.

Arne Schousboe, A. Schousboe, P. Krogsgaard‐Larsen, 2005, Bioorganic & medicinal chemistry.

Piperidine‐4‐sulphonic Acid, a New Specific GAB A Agonist

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1980, Journal of neurochemistry.

Ligands for glutamate receptors: design and therapeutic prospects.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 2000, Journal of medicinal chemistry.

Synthesis and crystal structure of two Copper(II) halide complexes with trans-1,2-cycloheptanediol

P. Krogsgaard‐Larsen, Y. Stenstrøm, R. Sillanpää, 1992 .

Design, synthesis, and biological evaluation of symmetrically and unsymmetrically substituted methoctramine-related polyamines as muscular nicotinic receptor noncompetitive antagonists.

P. Usherwood, V. Tumiatti, A. Minarini, 1999, Journal of medicinal chemistry.

A textbook of drug design and development

Tommy Liljefors, T. Liljefors, P. Krogsgaard‐Larsen, 1996 .

Synthesis and GABA uptake inhibitory properties of 6-aryl iminoxymethyl substituted nipecotic acids.

G. Schlewer, P. Krogsgaard‐Larsen, V. N’goka, 2004, European journal of medicinal chemistry.

Hydroxy- and amino-substituted piperidinecarboxylic acids as gamma-aminobutyric acid agonists and uptake inhibitors.

K. Schaumburg, P. Krogsgaard‐Larsen, E. Falch, 1982, Journal of medicinal chemistry.

Novel class of potent 4-arylalkyl substituted 3-isoxazolol GABA(A) antagonists: synthesis, pharmacology, and molecular modeling.

T. Liljefors, U. Kristiansen, P. Krogsgaard‐Larsen, 2002, Journal of medicinal chemistry.

Excitatory amino acid receptors : design of agonists and antagonists

P. Krogsgaard‐Larsen, J. J. Hansen, 1992 .

Synthesis of aryl- and heteroaryl-substituted 3-benzyloxyisothiazoles via Suzuki and Negishi cross-coupling reactions.

P. Krogsgaard‐Larsen, Birgitte H. Kaae, T. N. Johansen, 2004, The Journal of organic chemistry.

4-aryl-5-(4-piperidyl)-3-isoxazolol GABAA antagonists: synthesis, pharmacology, and structure-activity relationships.

J. Kehler, T. Liljefors, P. Krogsgaard‐Larsen, 2007, Journal of medicinal chemistry.

Intermolecular stereoselective alkenylation of chiral N-acylpyrrolidinium ions

P. Krogsgaard‐Larsen, Y. Stenstrøm, M. Thaning, 1992 .

Chemistry of 3-oxygenated isoxazoles. Formation and X-ray analysis of ethyl (RS)-6-tert-butyl-5-methyl-4-oxo-2,3-dihydro-4H-1,3-oxazine-2-carboxylate, an isoxazol-3(2H)-one rearrangement product

P. Krogsgaard‐Larsen, U. Madsen, L. Brehm, 1991 .

Friedel-Crafts Reactions. IV. The Use of Cyclic N-Formyl-2-Methoxyamines in Electrophilic Amidoalkylation of Aromatic Compounds.

P. Krogsgaard‐Larsen, H. Thøgersen, K. Nyberg, 1981 .

Analogues of the low-efficacy partial GABAA agonist 4-PIOL. Syntheses and in vitro pharmacological studies

P. Krogsgaard‐Larsen, B. Frølund, M. Amici, 1991 .

GABA agonists. Resolution, absolute stereochemistry, and enantioselectivity of (S)-(+)- and (R)-(-)-dihydromuscimol.

D. R. Curtis, P. Krogsgaard‐Larsen, E. Falch, 1985, Journal of medicinal chemistry.

Unambiguous synthesis of 1-methyl-3-hydroxypyrazoles

P. Krogsgaard‐Larsen, J. Ehrhardt, U. Madsen, 1998 .

Structural Analogues of GABA. Synthesis of 5-Aminomethyl-3-isothiazolol (Thiomuscimol).

P. Krogsgaard‐Larsen, T. Norberg, T. Anthonsen, 1976 .

Excitatory amino acids. Improved synthesis of ibotenic acid and X-ray analysis of an unexpected reaction product, (RS)-N-[2-(3-benzyloxyisoxazol-5-yl)-1-phenylethyl]-3-oxobutyramide

P. Krogsgaard‐Larsen, U. Madsen, L. Brehm, 1988 .

Regioselective lithiation and functionalization of 3-(benzyloxy)isothiazole: application to the synthesis of thioibotenic acid.

P. Krogsgaard‐Larsen, L. Bunch, U. Madsen, 2002, The Journal of organic chemistry.

SYNTHESIS OF 1-ACYL-3-PIPERIDONES AND RING EXPANSION OF METHYL 3-OXOPIPERIDINE-1-CARBOXYLATE WITH ETHYL DIAZOACETATE

P. Krogsgaard‐Larsen, T. Norberg, H. Hjeds, 1977 .

A convenient synthesis of 4-substituted 3-ethoxy-5-methylisoxazoles by palladium-catalyzed coupling reactions

P. Krogsgaard‐Larsen, T. N. Johansen, F. Sløk, 2001 .

Thermal and Photochemical Reactions of Aromatic Compounds in Trifluoroacetic Acid, Involving Carbocations and Radical Cations.

F. Radner, P. Krogsgaard‐Larsen, J. Pedersen, 1992 .

Syntheses of novel piperidin-4-ylphosphinic acid, and piperidin-4-ylphosphonic acid analogues of the inhibitory neurotransmitter 4-aminobutyric acid (GABA)

J. Kehler, P. Krogsgaard‐Larsen, B. Ebert, 1998 .

INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY NIPECOTIC ACID, VARIOUS ISOXAZOLES AND RELATED COMPOUNDS

P. Krogsgaard‐Larsen, G. Johnston, 1975, Journal of neurochemistry.

Organic Hydroxylamine Derivatives. XI. Structural Analogues of gamma-Aminobutyric Acid (GABA) of the Isoxazole Enol-betaine Type. Synthesis and the Crystal Structure of 3-Hydroxy-5-(3-aminopropyl)isoxazole Zwitterion.

C. Romming, P. Krogsgaard‐Larsen, B. Mannervik, 1974 .

Organic Hydroxylamine Derivatives. XII. Structural Analogues of gamma-Aminobutyric Acid (GABA) of the Isoxazole Enol-betaine Type. Synthesis of Some 3-Hydroxy-5-(1-aminoalkyl)isoxazole Zwitterions.

S. Christensen, P. Krogsgaard‐Larsen, B. Mannervik, 1974 .

Organic hydroxylamine derivatives. X. Structural analogues of gamma-aminobutyric acid (GABA) of the isoxazole enol-betaine type. Synthesis of 5,6,7,8-tetrahydro-4H-isoxazolo (4,5-D) azepin-3-ol zwitterion and 4,5,6,7-tetrahydroisoxazole (4,5-c) pyridin-3-ol zwitterion.

P. Krogsgaard‐Larsen, H. Hjeds, 1974, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry.

Organic hydroxylamine derivatives. IX. Structural analogues of GABA of the isoxazole enol-betaine type. Improved synthesis and the crystal structure of 3-hydroxy-5-(2-aminoethyl)isoxazole zwitterion (homomuscimol).

P. Krogsgaard‐Larsen, L. Brehm, H. Hjeds, 1974, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry.

Organic hydroxylamine derivatives. VII. Isoxazolin-5-ones. An investigation of a reaction sequence previously stated to give 3-hydroxyisoxazoles.

P. Krogsgaard‐Larsen, H. Hjeds, S. B. Christensen, 1973, Acta chemica Scandinavica.

Unprecedented migration of N-alkoxycarbonyl groups in protected pyroglutaminol.

P. Krogsgaard‐Larsen, L. Bunch, P. Norrby, 2001, Organic letters.

Excitatory amino acid receptor ligands: resolution, absolute stereochemistry, and enantiopharmacology of 2-amino-3-(4-butyl-3-hydroxyisoxazol-5-yl)propionic acid.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 1998, Journal of medicinal chemistry.

Syntheses and GABA receptor binding properties of 4-amino-1-, 2-, and 3-hydroxybutylphosphinic acids

J. Kehler, P. Krogsgaard‐Larsen, B. Ebert, 1999 .

Preparations of deuterium labelled guvacine and isoguvacine

S. Christensen, P. Krogsgaard‐Larsen, 1980 .

Partial agonists for brain GABA/benzodiazepine receptor complex

P. Krogsgaard‐Larsen, E. Falch, C. Braestrup, 1979, Nature.

STRUCTURE‐ACTIVITY STUDIES ON THE INHIBITION OF GABA BINDING TO RAT BRAIN MEMBRANES BY MUSCIMOL AND RELATED COMPOUNDS

P. Krogsgaard‐Larsen, G. Johnston, 1978, Journal of neurochemistry.

GABA Agonists and Uptake Inhibitors of Restricted Conformations: Structure-Activity Relations

P. Krogsgaard‐Larsen, 1978 .

The synthesis of 12-crown-3 ligands carrying ligating side-arms

P. Krogsgaard‐Larsen, J. Pedersen, W. Voigt, 1992 .

Mixed cyano-gilman cuprates: Advances in Conjugate addition to α, β-unsaturated pyroglutaminol

P. Krogsgaard‐Larsen, L. Bunch, U. Madsen, 2004 .

Mixed Cyano-Gilman Cuprates — Advances in Conjugate Addition to α,β-Unsaturated Pyroglutaminol.

P. Krogsgaard‐Larsen, L. Bunch, U. Madsen, 2002 .

Neuronal nicotinic acetylcholine receptors: structural revelations, target identifications, and therapeutic inspirations.

T. Liljefors, P. Krogsgaard‐Larsen, B. Frølund, 2005, Journal of medicinal chemistry.

High resolution electron microscopy and X-ray powder diffraction studies of Sr2Nb5O9

S. Wold, P. Krogsgaard‐Larsen, G. Svensson, 1990 .

Intermolecular effects on the geometry of [PtCl4]2-. X-ray diffraction studies of aqueous H2PtCl4 and crystalline (NH4)2PtCl4

Å. Oskarsson, P. Krogsgaard‐Larsen, J. Pedersen, 1992 .

Structure-activity relationships in the development of excitatory amino acid receptor agonists and competitive antagonists.

J. Watkins, P. Krogsgaard‐Larsen, T. Honoré, 1990, Trends in pharmacological sciences.

Addition--Elimination Equilibrium between Three-Coordinate Pt(0) and Five-Coordinate Pt(II) Species.

P. Krogsgaard‐Larsen, J. Pedersen, F. Ruffo, 1992 .

13C NMR chemical shifts and ring conformations of 2-hydroxy-1,3,2-dioxaborolane and 2-hydroxy-1,3,2-dioxaborinane and their methyl derivatives

P. Krogsgaard‐Larsen, K. Pihlaja, K. Rossi, 1985 .

Chemistry of gem-Dihalocyclopropanes. Part 21. An Example of Competition Between 1,3-Insertion and the Vinylcyclopropylidene/Cyclopentenylidene Rearrangement.

R. Ryhage, P. Krogsgaard‐Larsen, R. Isaksson, 1986 .

The molecular structure of monomeric CdCI2 at 805 K determined by gas electron diffraction

P. Krogsgaard‐Larsen, E. Sletten, A. Haaland, 1992 .

Activation of single heteromeric GABAA receptor ion channels by full and partial agonists

U. Kristiansen, P. Krogsgaard‐Larsen, T. Smart, 2004, The Journal of physiology.

Carbamoylcholine homologs: synthesis and pharmacology at nicotinic acetylcholine receptors.

P. Krogsgaard‐Larsen, E. Falch, I. Mikkelsen, 2004, European journal of pharmacology.

GABA agonists and uptake inhibitors. Synthesis, absolute stereochemistry, and enantioselectivity of (R)-(-)- and (S)-(+)-homo-beta-proline.

P. Krogsgaard‐Larsen, L. Brehm, L. Nielsen, 1990, Journal of medicinal chemistry.

The Binding of the GAB A Agonist [3H]THIP to Rat Brain Synaptic Membranes

P. Krogsgaard‐Larsen, E. Falch, 1982, Journal of neurochemistry.

Natural products and drug development : proceedings of the Alfred Benzon Symposium 20 held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen 7-11 August 1983

Povl Krogsgaard-Larsen, S. Brøgger Christensen, Helmer Kofod, 1984 .

The Crystal Structure of Chlorobis(diethyldithiocarbamato)-4-ethoxyphenyltellurium(IV) Hemidioxane Solvate, [TeCl(Et2NCS2)2(EtOPh)].0.5C4H8O2.

S. Wold, P. Krogsgaard‐Larsen, D. Beattie, 1990 .

A Radioimmunoassay for Ovalbumin.

M. Kulomaa, P. Krogsgaard‐Larsen, V. Parker, 1981 .

The Crystal and Molecular Structure of Lead(II) Nitrate : 18-Crown-6.

A. K. Vasudevan, I. Sylte, M. Drew, 1992 .

Synthesis of Mono- and Sesqui-terpenoids. XXI. Synthesis and Absolute Configuration of (E)-3-Formyl-(2,6,6-trimethyl-2-cyclohexenyl)-3-pentenal, a Sesquiterpenoid from a Marine Alga, Caulerpa ashmeadii.

P. Krogsgaard‐Larsen, K. Mori, J. Pedersen, 1992 .

Microwave Spectrum of Oxiranemethanol (Glycidol), the Assignment of a Second Hydrogen-Bonded Conformer and Conformational Composition in the Gas Phase and in Solution.

P. Krogsgaard‐Larsen, Y. Stenstrøm, H. Møllendal, 1992 .

Neuroactive polyamine wasp toxins: nuclear magnetic resonance spectroscopic analysis of the protolytic properties of philanthotoxin-343.

P. Krogsgaard‐Larsen, J. Jaroszewski, B. Frølund, 1996, Journal of medicinal chemistry.

Studies on the Possible Effects of Adsorption on the Product Distribution of Organic Electrode Reactions. II. Stereochemistry of the Anodic Acetoxylation of 1-t-Butylacenaphthene.

P. Krogsgaard‐Larsen, S. Svensson, L. Eberson, 1972 .

Potent 4-arylalkyl-substituted 3-isothiazolol GABA(A) competitive/noncompetitive antagonists: synthesis and pharmacology.

T. Liljefors, P. Krogsgaard‐Larsen, B. Frølund, 2006, Journal of medicinal chemistry.

Analogues of neuroactive polyamine wasp toxins that lack inner basic sites exhibit enhanced antagonism toward a muscle-type mammalian nicotinic acetylcholine receptor.

P. Usherwood, P. Krogsgaard‐Larsen, J. Jaroszewski, 1999, Journal of medicinal chemistry.

Design of excitatory amino acid receptor agonists, partial agonists and antagonists: ibotenic acid as a key lead structure

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 1996 .

Glutamate receptors and new glutamate agonists

P. Krogsgaard‐Larsen, T. Honoré, 1983 .

Excitatory Amino Acids: Studies on the Biochemical and Chemical Stability of Ibotenic Acid and Related Compounds

A. Schousboe, P. Krogsgaard‐Larsen, E. Nielsen, 1985, Journal of neurochemistry.

INHIBITION OF THE UPTAKE OF GABA AND RELATED AMINO ACIDS IN RAT BRAIN SLICES BY THE OPTICAL ISOMERS OF NIPECOTIC ACID

P. Krogsgaard‐Larsen, G. Johnston, B. Twitchin, 1976, Journal of neurochemistry.

SYNTHESES AND STRUCTURE‐ACTIVITY STUDIES OF ANALOGS OF Γ‐AMINOBUTYRIC ACID (GABA)

P. Krogsgaard‐Larsen, T. Honoré, H. Hjeds, 1979 .

STRUCTURE AND BIOLOGICAL ACTIVITY OF A SERIES OF CONFORMATIONALLY RESTRICTED ANALOGUES OF GABA

D. R. Curtis, P. Krogsgaard‐Larsen, G. Johnston, 1975, Journal of neurochemistry.

Betel nut constituents as inhibitors of γ-aminobutyric acid uptake

P. Krogsgaard‐Larsen, G. Johnston, A. Stephanson, 1975, Nature.

Inhibitors of the GABA uptake systems

P. Krogsgaard‐Larsen, 1980, Molecular and Cellular Biochemistry.

Base-catalyzed rearrangement of 6-bromo-3,6-dideoxy-aldohexono-1,4-lactones

R. Ryhage, P. Krogsgaard‐Larsen, K. Einarsson, 1986 .

Syntheses of Some Cyclic Amino Acids Structurally Related to the GABA Analogue Homo-beta-Proline.

P. Krogsgaard‐Larsen, P. Jacobsen, H. Hjeds, 1982 .

The Agonist-binding Domain of the Calcium-sensing Receptor Is Located at the Amino-terminal Domain*

P. O'Hara, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 1999, The Journal of Biological Chemistry.

Resolution, absolute stereochemistry, and enantiopharmacology of the GluR1-4 and GluR5 antagonist 2-amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid.

P. Krogsgaard‐Larsen, U. Madsen, J. Egebjerg, 1999, Chirality.

Textbook of drug design and discovery

Tommy Liljefors, T. Liljefors, P. Krogsgaard‐Larsen, 2016 .

New leads and targets in drug research : proceedings of the Alfred Benzon Symposium 33 held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen, 1-5 September 1991

S. Christensen, P. Krogsgaard‐Larsen, H. Kofod, 1992 .

Naturally-occurring excitatory amino acids as neurotoxins and leads in drug design.

P. Krogsgaard‐Larsen, J. J. Hansen, 1992, Toxicology letters.

The Anion Radical-Proton Donor Complex Mechanism of the Electrohydrodimerization of Diethyl Fumarate in N,N-Dimethylformamide.

P. Krogsgaard‐Larsen, V. Parker, A. Rane, 1981 .

Ibotenic acid and thioibotenic acid: a remarkable difference in activity at group III metabotropic glutamate receptors.

J. Greenwood, P. Krogsgaard‐Larsen, C. Sánchez, 2004, European journal of pharmacology.

Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.

D. R. Curtis, P. Krogsgaard‐Larsen, N. Diemer, 1991, Journal of medicinal chemistry.

Novel Glutamate Receptor Antagonists Selectively Protect Against Kainic Acid Neurotoxicity in Cultured Cerebral Cortex Neurons

A. Schousboe, P. Krogsgaard‐Larsen, A. Frandsen, 1990, Journal of neurochemistry.

New class of glutamate agonist structurally related to ibotenic acid

D. R. Curtis, P. Krogsgaard‐Larsen, D. Lodge, 1980, Nature.

Functional partial agonism at cloned human muscarinic acetylcholine receptors.

M. Brann, P. Krogsgaard‐Larsen, E. Falch, 1996, European journal of pharmacology.

(8E)-10-Hydroxydec-8-enoic Acid: its Isolation from Injured Fruit Bodies of Cantharellus tubaeformic and Synthetic Preparation.

P. Krogsgaard‐Larsen, H. Anke, O. Sterner, 1992 .

MUSCIMOL, A PSYCHOACTIVE CONSTITUENT OF AMANITA MUSCARIA, AS A MEDICINAL CHEMICAL MODEL STRUCTURE

K. Schaumburg, P. Krogsgaard‐Larsen, L. Brehm, 1982 .

Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: synthesis, modelling and molecular pharmacology.

J. Greenwood, P. Krogsgaard‐Larsen, B. Frølund, 2005, Bioorganic & medicinal chemistry.

Pharmacological and functional characterization of excitatory amino acid mediated cytotoxicity in cerebral cortical neurons

A. Schousboe, P. Krogsgaard‐Larsen, A. Frandsen, 1992, Cell Biology and Toxicology.

Pharmacology of AMPA/kainate receptors

P. Krogsgaard‐Larsen, U. Madsen, T. Stensbøl, 2001 .

Ionotropic excitatory amino acid receptor ligands. Synthesis and pharmacology of a new amino acid AMPA antagonist.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, U. Madsen, 2000, European journal of medicinal chemistry.

Pharmacology and toxicology of ATOA, an AMPA receptor antagonist and a partial agonist at GluR5 receptors

A. Schousboe, P. Krogsgaard‐Larsen, P. Wahl, 1998, Neuropharmacology.

Antagonist properties of a phosphono isoxazole amino acid at glutamate R1-4 (R,S)-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid receptor subtypes.

P. Krogsgaard‐Larsen, S. Traynelis, P. Wahl, 1998, Molecular pharmacology.

Synthesis and pharmacology of highly selective carboxy and phosphono isoxazole amino acid AMPA receptor antagonists.

P. Krogsgaard‐Larsen, B. Bang-Andersen, U. Madsen, 1996, Journal of medicinal chemistry.

Modulation of AMPA receptor function in relation to glutamatergic abnormalities in Alzheimer's disease.

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1994, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

GABA and glutamate receptors as therapeutic targets in neurodegenerative disorders.

P. Krogsgaard‐Larsen, 1992, Pharmacology & toxicology.

Excitatory amino acid receptors: Multiplicity and ligand specificity of the NMDA and AMPA receptor subtypes

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1992 .

Novel Class of Amino Acid Antagonists at Non‐N‐methyl‐D‐aspartic Acid Excitatory Amino Acid Receptors. Synthesis, in vitro and in vivo Pharmacology, and Neuroprotection.

D. R. Curtis, P. Krogsgaard‐Larsen, N. Diemer, 1991 .

Excitatory Amino Acid Induced Cytotoxicity in Cultured Neurons: Role of Intracellular Ca++ Homeostasis

A. Schousboe, P. Krogsgaard‐Larsen, P. Wahl, 1991 .

Neuromodulatory actions of glutamate, GABA and taurine: regulatory role of astrocytes.

A. Schousboe, P. Krogsgaard‐Larsen, A. Frandsen, 1991, Advances in experimental medicine and biology.

An anti-traditional interpretation of the LFER mechanistic message

S. Wold, P. Krogsgaard‐Larsen, E. Sletten, 1992 .

The role of meta and para Benzene derivatives in the evaluation of substituent effects : a multivariate data analysis

Otto Exner, Svante Wold, S. Wold, 1992 .

Partial GABAA receptor agonists. Synthesis and in vitro pharmacology of a series of nonannulated analogs of 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol.

U. Kristiansen, P. Krogsgaard‐Larsen, E. Falch, 1995, Journal of medicinal chemistry.

The selective activation of the glutamate receptor GluR5 by ATPA is controlled by serine 741.

T. Liljefors, P. Krogsgaard‐Larsen, J. Egebjerg, 2003, Molecular pharmacology.

Dual gamma-aminobutyric acid control of prolactin secretion in the rat.

D. Cocchi, P. Krogsgaard‐Larsen, V. Locatelli, 1979, Endocrinology.

Marine Alkaloids. 11. Flustramide B and Flustrarine B from the Marine Bryozoan Flustra foliacea. Synthesis of Flustrarine B.

R. Ryhage, P. Krogsgaard‐Larsen, C. Christophersen, 1986 .

Pharmacological profile of a novel class of muscarinic acetylcholine receptor agonists.

P. Krogsgaard‐Larsen, E. Falch, J. Larsen, 1986, European journal of pharmacology.

THIP, a specific and clinically active GABA agonist

P. Krogsgaard‐Larsen, 1984, Neuropharmacology.

Differences in agonist/antagonist binding affinity and receptor transduction using recombinant human gamma-aminobutyric acid type A receptors.

R. Mckernan, P. Krogsgaard‐Larsen, B. Ebert, 1997, Molecular pharmacology.

Different characteristics of AMPA receptor agonists acting at AMPA receptors expressed in Xenopus oocytes.

A. Schousboe, P. Krogsgaard‐Larsen, P. Wahl, 1996, European journal of pharmacology.

First Demonstration of a Functional Role for Central Nervous System Betaine/γ-Aminobutyric Acid Transporter (mGAT2) Based on Synergistic Anticonvulsant Action among Inhibitors of mGAT1 and mGAT2

Scott Slough, Arne Schousboe, A. Schousboe, 2005, Journal of Pharmacology and Experimental Therapeutics.

Correlation between Anticonvulsant Activity and Inhibitory Action on Glial γ-Aminobutyric Acid Uptake of the Highly Selective Mouse γ-Aminobutyric Acid Transporter 1 Inhibitor 3-Hydroxy-4-amino-4,5,6,7-tetrahydro-1,2-benzisoxazole and ItsN-Alkylated Analogs

Arne Schousboe, A. Schousboe, P. Krogsgaard‐Larsen, 2002, Journal of Pharmacology and Experimental Therapeutics.

Resolution, absolute stereochemistry and molecular pharmacology of the enantiomers of ATPA.

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1999, European journal of pharmacology.

Structure-activity relationships of selective GABA uptake inhibitors.

Arne Schousboe, A. Schousboe, J. Greenwood, 2006, Current topics in medicinal chemistry.

Action of bicyclic isoxazole GABA analogues on GABA transporters and its relation to anticonvulsant activity.

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1999, European journal of pharmacology.

NMDA receptor agonists derived from ibotenic acid. Preparation, neuroexcitation and neurotoxicity.

P. Krogsgaard‐Larsen, J. Ferkany, U. Madsen, 1990, European journal of pharmacology.

AMPA receptor agonists: resolution, configurational assignment, and pharmacology of (+)-(S)- and (-)-(R)-2-amino-3-[3-hydroxy-5-(2-pyridyl)-isoxazol-4-yl]-propionic acid (2-Py-AMPA).

P. Krogsgaard‐Larsen, E. Falch, B. Ebert, 1997, Chirality.

Detecting Protein–Protein Interactions in Living Cells: Development of a Bioluminescence Resonance Energy Transfer Assay to Evaluate the PSD-95/NMDA Receptor Interaction

P. Krogsgaard‐Larsen, J. L. Hansen, A. Kristensen, 2009, Neurochemical Research.

Rational design, synthesis, and pharmacological evaluation of 2-azanorbornane-3-exo,5-endo-dicarboxylic acid: a novel conformationally restricted glutamic acid analogue.

T. Liljefors, J. Greenwood, P. Krogsgaard‐Larsen, 2003, The Journal of organic chemistry.

The Binding of [3H]AMPA, a Structural Analogue of Glutamic Acid, to Rat Brain Membranes

P. Krogsgaard‐Larsen, T. Honoré, J. Lauridsen, 1982, Journal of neurochemistry.

Solid-phase synthesis of polyamine toxin analogues: potent and selective antagonists of Ca2+-permeable AMPA receptors.

P. Krogsgaard‐Larsen, J. Jaroszewski, K. Strømgaard, 2002, Journal of medicinal chemistry.

Solid-phase synthesis and biological evaluation of a combinatorial library of philanthotoxin analogues.

P. Usherwood, P. Krogsgaard‐Larsen, J. Jaroszewski, 2000, Journal of medicinal chemistry.

A novel class of conformationally restricted heterocyclic muscarinic agonists.

E Falch, P. Krogsgaard‐Larsen, E. Falch, 1986, Journal of medicinal chemistry.

Nitration of reactive aromatics via electron transfer. V: On the reaction between nitrogen dioxide and the radical cation hexafluorophosphates of some methyl-substituted naphthalenes

F. Radner, R. Ryhage, P. Krogsgaard‐Larsen, 1986 .

Cloning and characterization of a human orphan family C G-protein coupled receptor GPRC5D.

P. Krogsgaard‐Larsen, B. Brodin, H. Bräuner‐Osborne, 2001, Biochimica et biophysica acta.

Relative disposition of the GABA agonists THIP and muscimol in the brain of the rat

A. Guidotti, P. Krogsgaard‐Larsen, F. Moroni, 1982, The Journal of pharmacy and pharmacology.

Activity of novel 4-PIOL analogues at human α1β2γ2S GABAA receptors—correlation with hydrophobicity

T. Liljefors, P. Krogsgaard‐Larsen, B. Frølund, 2002 .

2-Amino-3-(3-hydroxy-1,2,5-thiadiazol-4-yl)propionic acid: resolution, absolute stereochemistry and enantiopharmacology at glutamate receptors.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, K. Frydenvang, 2002, Bioorganic & medicinal chemistry.

Molecular pharmacology of homologues of ibotenic acid at cloned metabotropic glutamic acid receptors.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, B. Nielsen, 1998, European journal of pharmacology.

In vivo changes in the GABA content of nerve endings (synaptosomes) induced by inhibitors of GABA uptake

A. Schousboe, P. Krogsgaard‐Larsen, J. Wood, 1980, Neuropharmacology.

High‐Affinity Uptake of (RS)‐Nipecotic Acid in Astrocytes Cultured from Mouse Brain. Comparison with GABA Transport

A. Schousboe, P. Krogsgaard‐Larsen, O. Larsson, 1980, Journal of neurochemistry.

Synthesis and structure-activity studies on excitatory amino acids structurally related to ibotenic acid.

D. R. Curtis, P. Krogsgaard‐Larsen, L. Brehm, 1985, Journal of medicinal chemistry.

Flash photolysis studies of highly hindered diarylcarbenes. Optical absorption spectrum and reaction kinetics of 2,2',4,4'6,6'-hexachlorodiphenylcarbene

P. Krogsgaard‐Larsen, R. Leung-Toung, J. Pedersen, 1992 .

Synthesis and Crystallography of 1,2,3,4,6,7-Hexachloronaphthalene and 1,2,3,5,6,7-Hexachloronaphthalene.

P. Krogsgaard‐Larsen, A. Bergman, E. Jakobsson, 1992 .

Electron Transfer Reactions. III. The Application of Derivative Cyclic Voltammetry for the Determination of Rate Constants and alpha Values for Heterogeneous Electron Transfer Processes: the Reduction of Organic Anions.

C. Romming, P. Krogsgaard‐Larsen, Haijiang Wang, 1992 .

Inhibition of the betaine-GABA transporter (mGAT2/BGT-1) modulates spontaneous electrographic bursting in the medial entorhinal cortex (mEC)

A. Schousboe, P. Krogsgaard‐Larsen, K. Wilcox, 2008, Epilepsy Research.

Molecular pharmacology of gamma-aminobutyric acid type A receptor agonists and partial agonists in oocytes injected with different alpha, beta, and gamma receptor subunit combinations.

J. Kemp, P. Whiting, P. Krogsgaard‐Larsen, 1994, Molecular pharmacology.

A novel selective γ-aminobutyric acid transport inhibitor demonstrates a functional role for GABA transporter subtype GAT2/BGT-1 in the CNS

Arne Schousboe, H. Steve White, A. Schousboe, 2006, Neurochemistry International.

Glutamate and gaba receptors and transporters : structure,function and pharmacology

A. Schousboe, P. Krogsgaard‐Larsen, J. Egebjerg, 2001 .

[3H]ATPA: a high affinity ligand for GluR5 kainate receptors

P. Skolnick, P. Krogsgaard‐Larsen, D. Bleakman, 1999, Neuropharmacology.

Synthesis and receptor binding affinity of new selective GluR5 ligands.

T. H. Johansen, P. Krogsgaard‐Larsen, L. Bunch, 2001, Bioorganic & medicinal chemistry.

Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPO

A. Schousboe, P. Krogsgaard‐Larsen, J. Wood, 1983, Neuropharmacology.

The action of conformationally restricted analogues of GABA onLimulus andHelix central neurones

P. Krogsgaard‐Larsen, R. Walker, V. A. James, 1978, Experientia.

The actions of ibotenate, homoibotenate analogues and AMPA on central neurons of Hirudo, Limulus and Helix

P. Krogsgaard‐Larsen, R. Walker, E. Nielsen, 1982 .

Amplification by glycine of the effect of the GABA transport inhibitor THPO on synaptosomal GABA level

A. Schousboe, P. Krogsgaard‐Larsen, J. Wood, 1988, Neurochemical Research.

Characterization of the uptake of GABA, nipecotic acid and cis-4-OH-nipecotic acid in cultured neurons and astrocytes

A. Schousboe, P. Krogsgaard‐Larsen, O. Larsson, 1985, Neurochemistry International.

Heterocyclic GABA analogues as selective inhibitors of astroglial GABA uptake.

A. Schousboe, P. Krogsgaard‐Larsen, L. Hertz, 1981, Advances in biochemical psychopharmacology.

INHIBITORS OF GABA UPTAKE. SYNTHESES AND PROTON NMR SPECTROSCOPIC INVESTIGATIONS OF GUVACINE, (3RS,4SR)-4-HYDROXYPIPERIDINE-3-CARBOXYLIC ACID, AND RELATED COMPOUNDS

K. Schaumburg, P. Krogsgaard‐Larsen, K. Thyssen, 1978 .

Muscimol Analogues. II. Synthesis of Some Bicyclic 3-Isoxazolol Zwitterions.

G. Schroll, P. Krogsgaard‐Larsen, H. Hope, 1977 .

STRUCTURAL ANALOGS OF GABA. A NEW CONVENIENT SYNTHESIS OF MUSCIMOL

S. Christensen, P. Krogsgaard‐Larsen, J. Vialle, 1976 .

Isoxazole amino-acids as glutamic acid agonists. Synthesis of some analogues and homologues of ibotenic acid.

P. Krogsgaard‐Larsen, J. J. Hansen, 1980, Journal of the Chemical Society. Perkin transactions 1.

Modification of the philanthotoxin-343 polyamine moiety results in different structure-activity profiles at muscle nicotinic ACh, NMDA and AMPA receptors

P. Usherwood, P. Krogsgaard‐Larsen, J. Jaroszewski, 2003, Neuropharmacology.

Muscimol, a psychoactive constituent of Amanita muscaria, as a medicinal chemical model structure.

K. Schaumburg, P. Krogsgaard‐Larsen, L. Brehm, 1981, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry.

Solid phase synthesis and biological evaluation of enantiomerically pure wasp toxin analogues PhTX-343 and PhTX-12.

P. Usherwood, P. Krogsgaard‐Larsen, J. Jaroszewski, 2000, Chirality.

GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnotic.

T. Liljefors, P. Krogsgaard‐Larsen, B. Frølund, 2004, Biochemical pharmacology.

Syntheses and GABA uptake properties of 6-ether- and 6-enol ether-substituted nipecotic acids.

C. Bissantz, G. Schlewer, P. Krogsgaard‐Larsen, 2004, European journal of medicinal chemistry.

Algal carotenoids. XXXVIII: Structural assignments of geometrical isomers of fucoxanthin

P. Krogsgaard‐Larsen, S. Liaaen-Jensen, J. Sandström, 1992 .

Inhibition of gamma-aminobutyric acid release by gamma-aminobutyric acid agonist drugs. Pharmacology of the gamma-aminobutyric acid autoreceptor.

P. Krogsgaard‐Larsen, R. Cantrill, M. Brennan, 1981, Molecular pharmacology.

Carbamoylcholine homologs: novel and potent agonists at neuronal nicotinic acetylcholine receptors.

P. Krogsgaard‐Larsen, E. Falch, I. Mikkelsen, 2003, Molecular pharmacology.

Phosphinic, phosphonic and seleninic acid bioisosteres of isonipecotic acid as novel and selective GABAC receptor antagonists

J. Kehler, P. Krogsgaard‐Larsen, B. Frølund, 2003, Neurochemistry International.

Functional importance of the Ala(116)-Pro(136) region in the calcium-sensing receptor. Constitutive activity and inverse agonism in a family C G-protein-coupled receptor.

M. Brann, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 2000, The Journal of biological chemistry.

The orthosteric GABAA receptor ligand Thio‐4‐PIOL displays distinctly different functional properties at synaptic and extrasynaptic receptors

U. Kristiansen, N. O. Dalby, J. Cryan, 2013, British journal of pharmacology.

Design, synthesis and pharmacology of model compounds for indirect elucidation of the topography of AMPA receptor sites

P. Krogsgaard‐Larsen, B. Frølund, U. Madsen, 1993 .

Novel 1-hydroxyazole bioisosteres of glutamic acid. Synthesis, protolytic properties, and pharmacology.

J. Greenwood, P. Krogsgaard‐Larsen, S. Morel, 2002, Journal of Medicinal Chemistry.

Crystal and Molecular Structure of 2,3-Dichloro-4,5-dimethoxy-1-(2,3,4-trichloro-6-methoxyphenoxy)benzene: a Derivative of the Oxidative Coupling Product of 4,5,6-Trichloroguaiacol.

P. Krogsgaard‐Larsen, E. Sletten, J. Sandström, 1992 .

Selective GABA Transporter Inhibitors Tiagabine and EF1502 Exhibit Mechanistic Differences in Their Ability to Modulate the Ataxia and Anticonvulsant Action of the Extrasynaptic GABAA Receptor Agonist Gaboxadol

A. Schousboe, P. Krogsgaard‐Larsen, H. White, 2011, Journal of Pharmacology and Experimental Therapeutics.

Heterocyclic muscarinic agonists. Synthesis and biological activity of some bicyclic sulfonium arecoline bioisosteres.

E Falch, E Meier, P. Krogsgaard‐Larsen, 1988, Journal of medicinal chemistry.

Molecular pharmacology of 4-substituted glutamic acid analogues at ionotropic and metabotropic excitatory amino acid receptors.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, T. Stensbøl, 1997, European journal of pharmacology.

GABA‐A agonists and GABA uptake inhibitors: Structure‐activity relationships

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1990 .

.gamma.-Aminobutyric acid agonists, antagonists, and uptake inhibitors. Design and therapeutic aspects

P. Krogsgaard‐Larsen, 1982 .

A novel class of potent 3-isoxazolol GABA(A) antagonists: design, synthesis, and pharmacology.

T. Liljefors, U. Kristiansen, P. Krogsgaard‐Larsen, 2000, Journal of medicinal chemistry.

EFFECTS OF GABA ANALOGUES OF RESTRICTED CONFORMATION ON GABA TRANSPORT IN ASTROCYTES AND BRAIN CORTEX SLICES AND ON GABA RECEPTOR BINDING

A. Schousboe, P. Krogsgaard‐Larsen, L. Hertz, 1979, Journal of neurochemistry.

Probing the Orthosteric Binding Site of GABAA Receptors with Heterocyclic GABA Carboxylic Acid Bioisosteres

P. Krogsgaard‐Larsen, B. Frølund, R. Bergmann, 2014, Neurochemical Research.

Design and synthesis of a new series of 4-alkylated 3-isoxazolol GABAA antagonists

T. Liljefors, U. Kristiansen, P. Krogsgaard‐Larsen, 2003 .

Characterization of the GABAA Receptor Recognition Site Through Ligand Design and Pharmacophore Modeling

T. Liljefors, P. Krogsgaard‐Larsen, B. Frølund, 2004 .

P. Krogsgaard‐Larsen, B. Frølund, B. Ebert, 2003, Bioorganic & medicinal chemistry.

Synthesis, theoretical and structural analyses, and enantiopharmacology of 3-carboxy homologs of AMPA.

J. Greenwood, P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, 2004, Chirality.

Towards rational design of AMPA receptor ligands: An integrated medicinal, computational, biostructural and molecular pharmacological approach

J. Greenwood, P. Krogsgaard‐Larsen, J. Kastrup, 2002 .

Anticonvulsant activity of the gamma-aminobutyric acid uptake inhibitor N-4,4-diphenyl-3-butenyl-4,5,6,7-tetrahydroisoxazolo[4,5-c]pyridin-3-ol .

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1993, European journal of pharmacology.

J. Scheel-Krüger, P. Krogsgaard‐Larsen, J. Arnt, 1979, The Journal of pharmacy and pharmacology.

Pharmacological studies of interactions between benzodiazepines and GABA receptors

P. Krogsgaard‐Larsen, J. Arnt, 1980, Brain Research Bulletin.

A stereochemical anomaly: the cyclised (R)-AMPA analogue (R)-3-hydroxy-4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridine-5-carboxylic acid [(R)-5-HPCA] resembles (S)-AMPA at glutamate receptors.

T. Liljefors, J. Greenwood, P. Krogsgaard‐Larsen, 2004, Organic & biomolecular chemistry.

Synthesis of Some 4-Aminoalkyl-5-methyl-3-isoxazolols Structurally Related to Muscimol and gamma-Aminobutyric Acid (GABA).

J. Møller, P. Krogsgaard‐Larsen, J. Vialle, 1976 .

Evidence for a single glutamate receptor of the ionotropic kainate/quisqualate type.

J. Henley, P. Krogsgaard‐Larsen, E. Barnard, 1989, The New biologist.

Resolution, configurational assignment, and enantiopharmacology at glutamate receptors of 2-amino-3-(3-carboxy-5-methyl-4-isoxazolyl)propionic acid (ACPA) and demethyl-ACPA.

P. Krogsgaard‐Larsen, K. Frydenvang, U. Madsen, 2001, Chirality.

GABA and benzodiazepine receptors. Studies on their localization in the hippocampus and their interaction with central dopamine neurons in the rat brain.

K. Fuxe, L. Agnati, P. Krogsgaard‐Larsen, 1981, Advances in biochemical psychopharmacology.

The structure of muscimol, a GABA analogue of restricted conformation.

P. Krogsgaard‐Larsen, L. Brehm, H. Hjeds, 1972, Acta chemica Scandinavica.

Stereospecific GABAB Receptor Antagonism

U. Kristiansen, P. Krogsgaard‐Larsen, B. Frølund, 1996 .

Scientific social responsibility: a call to arms.

Flemming Besenbacher, F. Besenbacher, P. Krogsgaard‐Larsen, 2011, Angewandte Chemie.

The AMPA receptor binding site: focus on agonists and competitive antagonists.

P. Krogsgaard‐Larsen, U. Madsen, T. Stensbøl, 2002, Current pharmaceutical design.

Selective Inhibitors of Glial GABA Uptake: Synthesis, Absolute Stereochemistry, and Pharmacology of the Enantiomers of 3‐Hydroxy‐4‐amino‐4,5,6,7‐tetrahydro‐1,2‐benzisoxazole (exo‐THPO) and Analogues.

P. Krogsgaard‐Larsen, 2000 .

Anticonvulsant activity of the glial GABA uptake inhibitor, THAO, in chemical seizures.

A. Schousboe, P. Krogsgaard‐Larsen, R. Harbaugh, 1989, European journal of pharmacology.

GABA Uptake Inhibitors: Kinetics and Molecular Pharmacology

A. Schousboe, P. Krogsgaard‐Larsen, E. Falch, 1991 .

Anticonvulsant activity of GABA uptake inhibitors and their prodrugs following central or systemic administration.

B. Meldrum, M. Croucher, P. Krogsgaard‐Larsen, 1983, European journal of pharmacology.

Identification of a novel NMDA receptor in rat cerebellum.

E. Wong, P. Krogsgaard‐Larsen, B. Ebert, 1991, European journal of pharmacology.

New methods for the introduction of substitutents into thiazoles

P. Krogsgaard‐Larsen, Y. Stenstrøm, S. Grundvig, 1992 .

Probing α4βδ GABAA Receptor Heterogeneity: Differential Regional Effects of a Functionally Selective α4β1δ/α4β3δ Receptor Agonist on Tonic and Phasic Inhibition in Rat Brain

N. O. Dalby, P. Krogsgaard‐Larsen, B. Frølund, 2014, The Journal of Neuroscience.

Interaction of CPCCOEt with a chimeric mGlu1b and calcium sensing receptor.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, A. Jensen, 1999, Neuroreport.

Glutamate and aspartate agonists structurally related to ibotenic acid

P. Krogsgaard‐Larsen, T. Honoré, J. J. Hansen, 1981, Molecular and Cellular Biochemistry.

Deuterium labelling of the GABA agonists THIP, piperidine‐4‐sulphonic acid and the gaba uptake inhibitor THPO

P. Krogsgaard‐Larsen, E. Falch, J. S. Johansen, 1982 .

A tetrazolyl-substituted subtype-selective AMPA receptor agonist.

J. Greenwood, P. Krogsgaard‐Larsen, J. Kastrup, 2007, Journal of medicinal chemistry.

Baclofen-induced, calcium-dependent stimulation of in vivo release ofd-[3H]aspartate from rat hippocampus monitored by intracerebral microdialysis

A. Schousboe, P. Krogsgaard‐Larsen, N. Diemer, 1989, Neurochemical Research.

Gaba-neuro-transmitters : pharmacochemical, biochemical, and pharmacological aspects : proceedings of the Alfred Benzon Symposium 12 held at the premises of the Royal Danish Academy of Sciences and Letters, Copenhagen 21-25 May 1978

J. Scheel-Krüger, P. Krogsgaard‐Larsen, H. Kofod, 1979 .

Studies involving avermectin and the 4-aminobutyric acid (GABA) receptor of Ascaris suum muscle†

P. Krogsgaard‐Larsen, L. Holden-Dye, R. Walker, 1988 .

Sleep promoting effect of a putative glial gamma-aminobutyric acid uptake blocker applied in the thalamus of cats.

G. Juhász, A. Schousboe, Z. Emri, 1991, European journal of pharmacology.

Pharmacology of (S)‐homoquisqualic acid and (S)‐2‐amino‐5‐phosphonopentanoic acid [(S)‐AP5] at cloned metabotropic glutamate receptors

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, Povl Krogsgaard‐Larsen, 1998, British journal of pharmacology.

Glutamate receptor ligands: synthesis, stereochemistry, and enantiopharmacology of methylated 2-aminoadipic acid analogs.

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, K. Frydenvang, 2002, Chirality.

Resolution, configurational assignment, and enantiopharmacology of 2-amino-3-[3-hydroxy-5-(2-methyl-2H- tetrazol-5-yl)isoxazol-4-yl]propionic acid, a potent GluR3- and GluR4-preferring AMPA receptor agonist.

P. Krogsgaard‐Larsen, B. Bang-Andersen, K. Frydenvang, 2000, Chirality.

Ibotenic acid analogues. Synthesis, molecular flexibility, and in vitro activity of agonists and antagonists at central glutamic acid receptors.

P. Krogsgaard‐Larsen, T. Honoré, J. Lauridsen, 1985, Journal of medicinal chemistry.

IBOTENIC ACID ANALOGS. SYNTHESIS, MOLECULAR FLEXIBILITY, AND IN VITRO ACTIVITY OF AGONISTS AND ANTAGONISTS AT CENTRAL GLUTAMIC ACID RECEPTORS

P. Krogsgaard‐Larsen, T. Honoré, J. Lauridsen, 1985 .

Structural characteristics of isoxazol-3-ol and isothiazol-3-ol, carboxy group bioisosteres examined by X-ray crystallography and ab initio calculations

T. Liljefors, P. Krogsgaard‐Larsen, J. Jaroszewski, 1997 .

Isoxazol-5(4H)-ones. X-Ray crystal structures of a 4-hydroxyisoxazol-5(4H)-one and a [4,4′-biisoxazole]-5(4H),5′(4′H)-dione formed by oxygen oxidation of 3-tert-butyl-4-methylisoxazol-5(4H)-one

P. Krogsgaard‐Larsen, L. Brehm, J. S. Johansen, 1992 .

Proton Magnetic Resonance Analysis of Ring-substituted 2-Chloro-1,3,2-dioxaphosphorinanes.

P. Krogsgaard‐Larsen, S. Svensson, K. Bergesen, 1972 .

Equilibrium binding characteristics of [3H]thiomuscimol

P. Krogsgaard‐Larsen, N. Diemer, B. Frølund, 1999, Neurochemistry International.

N-methyl-D-aspartic acid receptor agonists: resolution, absolute stereochemistry, and pharmacology of the enantiomers of 2-amino-2-(3-hydroxy-5-methyl-4-isoxazolyl)acetic acid.

P. Krogsgaard‐Larsen, K. Frydenvang, U. Madsen, 1996, Journal of medicinal chemistry.

Excitatory amino acid receptor ligands. Synthesis and biological activity of 3-isoxazolol amino acids structurally related to homoibotenic acid.

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1992, Journal of medicinal chemistry.

Excitatory amino acid agonists. Enzymic resolution, X-ray structure, and enantioselective activities of (R)- and (S)-bromohomoibotenic acid.

D. R. Curtis, P. Krogsgaard‐Larsen, B. Nielsen, 1989, Journal of medicinal chemistry.

Enzymic resolution and binding to rat brain membranes of the glutamic acid agonist alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid.

P. Krogsgaard‐Larsen, E. Nielsen, J. J. Hansen, 1983, Journal of medicinal chemistry.

Molecular pharmacology of the AMPA agonist, (S)-2-amino-3-(3-hydroxy-5-phenyl-4-isoxazolyl)propionic acid [(S)-APPA] and the AMPA antagonist, (R)-APPA

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1994, Neurochemistry International.

Functional pharmacology of cloned heterodimeric GABAB receptors expressed in mammalian cells

P. Krogsgaard‐Larsen, H. Bräuner‐Osborne, Povl Krogsgaard‐Larsen, 1999, British journal of pharmacology.

Neuronal Nicotinic Acetylcholine Receptors: Structural Revelations, Target Identifications, and Therapeutic Inspirations

T. Liljefors, P. Krogsgaard‐Larsen, A. Jensen, 2005 .

Esters of isoguvacine as potential prodrugs.

P. Krogsgaard‐Larsen, E. Falch, A. N. Christensen, 1981, Journal of medicinal chemistry.

Autoradiographic localization of binding sites for the γ-aminobutyric acid analogues 4,5,6,7-tetrahydroisoxazolo[5,4-c]pyridin-3-ol (THIP)isoguvacine and baclofen on cultured neurons of rat cerebellum and spinal cord

P. Krogsgaard‐Larsen, L. Hösli, E. Hösli, 1985, Neuroscience Letters.

Chemistry and pharmacology of the GABA agonists THIP (Gaboxadol) and isoguvacine

P. Krogsgaard‐Larsen, E. Falch, V. Christensen, 1984 .

Chapter 5. GABA Agonists and Antagonists

P. Krogsgaard‐Larsen, P. Krogsgaard-Larsen, A. V. Christensen, 1980 .

Medicinal chemistry education: what is needed and where is it going?

P. Krogsgaard‐Larsen, H. Timmerman, D. Triggle, 2005 .

Demonstration of glutamic acid decarboxylase, and GABA receptor and uptake sites in the cerebellum: Combined tmmunocytochemistry and autoradiography

J. Wu, S. Palay, V. Chan‐Palay, 1979, Brain Research Bulletin.

THIP, isoguvacine, isoguvacine oxide, and related GABA agonists.

K. Bogeso, P. Krogsgaard‐Larsen, T. Aaes-Jørgensen, 1981, Advances in biochemical psychopharmacology.

Hydroxylated Analogues of 5‐Aminovaleric Acid as 4‐Aminobutyric AcidB Receptor Antagonists: Stereostructure‐Activity Relationships

U. Kristiansen, P. Krogsgaard‐Larsen, E. Falch, 1992, Journal of neurochemistry.

Pharmacodynamic effects and possible therapeutic uses of THIP, a specific GABA-agonist

P. Krogsgaard‐Larsen, O. Svendsen, A. V. Christensen, 1982, Pharmaceutisch Weekblad.

D. Gloriam, P. Krogsgaard‐Larsen, N. Plath, 2013, Journal of medicinal chemistry.

Proinflammatory Cytokines and Sphingolipids at the Crossroad between Nociceptors and the Immune System

H. Kehlet, P. Krogsgaard‐Larsen, A. Svejgaard, 2011 .

Photolysis of 1,2,3-thiadiazole. Formation of thiirene by secondary photolysis of thioketene

P. Krogsgaard‐Larsen, J. Pedersen, B. Larsen, 1992 .

Excitatory amino acid receptor ligands: asymmetric synthesis, absolute stereochemistry and pharmacology of (R)- and (S)-homoibotenic acid.

P. Krogsgaard‐Larsen, U. Madsen, B. Ebert, 1995, Bioorganic & medicinal chemistry.

GABA receptors on the somatic muscle cells of the parasitic nematode, Ascaris suum: stereoselectivity indicates similarity to a GABAA‐type agonist recognition site

P. Krogsgaard‐Larsen, L. Holden-Dye, R. Walker, 1989, British journal of pharmacology.

Biostructural and pharmacological studies of bicyclic analogues of the 3-isoxazolol glutamate receptor agonist ibotenic acid.

J. Greenwood, P. Krogsgaard‐Larsen, J. Kastrup, 2010, Journal of medicinal chemistry.

Glycine Antagonists Structurally Related to Muscimol, THIP, or Isoguvacine

D. R. Curtis, P. Krogsgaard‐Larsen, H. Hjeds, 1982, Journal of neurochemistry.

Piperidinyl-3-phosphinic acids as novel uptake inhibitors of the neurotransmitter gamma-aminobutyric acid (GABA).

J. Kehler, P. Krogsgaard‐Larsen, T. Stensbøl, 1999, Bioorganic & medicinal chemistry letters.

Synthesis and receptor binding of 5‐amino[3H]2methyl‐3‐isothiazolol ([3H]thiomuscimol), a specific GABAa agonist photoaffinity label

P. Krogsgaard‐Larsen, B. Frølund, B. Ebert, 1995 .

Electrophysiological studies of the GABAA receptor ligand, 4‐PIOL, on cultured hippocampal neurones

U. Kristiansen, J. Lambert, P. Krogsgaard‐Larsen, 1991, British journal of pharmacology.

Deuterium labelling of the GABA agonist thiomuscimol

P. Krogsgaard‐Larsen, P. Jacobsen, 1984 .

GABA agonists and potential antagonists related to muscimol

P. Krogsgaard‐Larsen, J. Arnt, 1979, Brain Research.

Synthesis and pharmacology of seleninic acid analogues of the inhibitory neurotransmitter gamma-aminobutyric acid.

J. Kehler, P. Krogsgaard‐Larsen, N. Stuhr-Hansen, 2000, Organic letters.

GABAA agonists: resolution and pharmacology of (+)- and (-)-isoguvacine oxide.

P. Krogsgaard‐Larsen, B. Frølund, L. Jeppesen, 1995, Chirality.

Muscimol Analogues Injected into Substantia Nigra: A Valuable New In Vivo Model for GABA-Ergic Drugs

P. Krogsgaard‐Larsen, J. Arnt, H. Hjeds, 1978 .

Thiomuscimol, a new photoaffinity label for the GABAA receptor.

P. Krogsgaard‐Larsen, B. Ebert, M. Witt, 1995, European journal of pharmacology.

GABA autoreceptors: structure-activity relationships for agonists.

P. Krogsgaard‐Larsen, R. Cantrill, M. Brennan, 1981, Advances in biochemical psychopharmacology.

Effects of GABAA receptors activation on brain glucose metabolism in normal subjects and temporal lobe epilepsy (TLE) patients. A positron emission tomography (PET) study Part II: The focal hypometabolism is reactive to GABAA agonist administration in TLE

F. Mauguière, R. Peyron, L. Garcia-Larrea, 1994, Epilepsy Research.

AMPA receptor agonists: synthesis, protolytic properties, and pharmacology of 3-isothiazolol bioisosteres of glutamic acid.

P. Krogsgaard‐Larsen, J. Jaroszewski, B. Frølund, 1997, Journal of medicinal chemistry.