Nancy Smith

发表

Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells.

P. Neufer, P. MacDonald, A. Gloyn, 2015, The Journal of clinical investigation.

Chronic insulin infusion induces reversible glucose intolerance in lean rats yet ameliorates glucose intolerance in obese rats.

P. MacDonald, C. Soltys, P. Light, 2017, Biochimica et biophysica acta. General subjects.

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

P. MacDonald, A. Gloyn, M. Ferdaoussi, 2022, bioRxiv.

Impacts of the COVID-19 pandemic on a human research islet program

P. MacDonald, Nancy Smith, A. Spigelman, 2021, bioRxiv.

A role for PKD1 in insulin secretion downstream of P2Y1 receptor activation in mouse and human islets

P. MacDonald, M. Ferdaoussi, Nancy Smith, 2019, Physiological reports.

A genome-wide CRISPR screen identifies CALCOCO2 as a regulator of beta cell function influencing type 2 diabetes risk

P. MacDonald, A. Gloyn, Seung K. Kim, 2022, Nature Genetics.

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

P. MacDonald, M. Ferdaoussi, X. Dai, 2017, Scientific Reports.

Heterogenous impairment of α-cell function in type 2 diabetes is linked to cell maturation state

Robert C. Jones, S. Quake, P. MacDonald, 2021, bioRxiv.

Interleukin-1 signaling contributes to acute islet compensation.

P. MacDonald, M. Ferdaoussi, X. Dai, 2016, JCI insight.

β-cell responses to high fat feeding: A role and mechanism for redox sensing by SENP1

P. MacDonald, M. Ferdaoussi, X. Dai, 2023, bioRxiv.

β-Cell Knockout of SENP1 Reduces Responses to Incretins and Worsens Oral Glucose Tolerance in High-Fat Diet–Fed Mice

P. MacDonald, M. Ferdaoussi, Nancy Smith, 2021, Diabetes.

β-cell SENP1 facilitates responsiveness to incretins and limits oral glucose intolerance in high fat fed mice

P. MacDonald, M. Ferdaoussi, Nancy Smith, 2020, bioRxiv.

Improved glucose tolerance with DPPIV inhibition requires β‐cell SENP1 amplification of glucose‐stimulated insulin secretion

P. MacDonald, M. Ferdaoussi, X. Dai, 2020, Physiological reports.

Heterogenous impairment of α cell function in type 2 diabetes is linked to cell maturation state.

Robert C. Jones, S. Quake, K. Kaestner, 2022, Cell metabolism.

Interleukin-1 signaling contributes to acute islet compensation.

P. MacDonald, M. Ferdaoussi, X. Dai, 2016, JCI insight.

SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

P. MacDonald, M. Ferdaoussi, X. Dai, 2017, Scientific Reports.

A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding

M. Ferdaoussi, X. Dai, Nancy Smith, 2024, Nature communications.