C. Newgard

C. Newgard, J. Jiménez-Chillarón, A. Gómez-Foix, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Glucose metabolism as a target of histone deacetylase inhibitors.

O. Ilkayeva, C. Newgard, J. Rathmell, 2009, Molecular endocrinology.

Metabolic Mechanisms of Muscle Insulin Resistance

C. Newgard, D. Muoio, J. An, 2008 .

MuRF2 regulates PPARγ1 activity to protect against diabetic cardiomyopathy and enhance weight gain induced by a high fat diet

C. Newgard, J. Schisler, Joseph A. Hill, 2015, Cardiovascular Diabetology.

Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.

F. Hu, D. Scholtens, O. Ilkayeva, 2018, The Journal of nutrition.

Stimulation of Human and Rat Islet β-Cell Proliferation with Retention of Function by the Homeodomain Transcription Factor Nkx6.1

C. Newgard, J. Schisler, R. Mirmira, 2008, Molecular and Cellular Biology.

Increasing fructose 2,6-bisphosphate overcomes hepatic insulin resistance of type 2 diabetes.

C. Newgard, Chaodong Wu, A. Lange, 2002, American journal of physiology. Endocrinology and metabolism.

Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway.

C. Newgard, J. McGarry, D. W. Foster, 1984, The Journal of biological chemistry.

PGC-1β in the Regulation of Hepatic Glucose and Energy Metabolism*

Jiandie D. Lin, Paul T. Tarr, P. Puigserver, 2003, Journal of Biological Chemistry.

Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells.

Jiandie D. Lin, Paul T. Tarr, B. Spiegelman, 2003, The Journal of biological chemistry.

PGC-1beta in the regulation of hepatic glucose and energy metabolism.

Jiandie D. Lin, Paul T. Tarr, P. Puigserver, 2003, The Journal of biological chemistry.

Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids.

J. H. Johnson, C. Newgard, R. Unger, 1995, The Journal of biological chemistry.

Marginal vitamin B-6 deficiency decreases plasma (n-3) and (n-6) PUFA concentrations in healthy men and women.

J. Gregory, C. Newgard, Y. Lamers, 2012, The Journal of nutrition.

Circulating long chain acylcarnitines and outcomes in diabetic heart failure: an HF-ACTION clinical trial substudy

W. Kraus, Svati H Shah, G. Felker, 2021, Cardiovascular Diabetology.

Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.

Robert V Farese, C. Newgard, M. Sajan, 2007, American journal of physiology. Endocrinology and metabolism.

Sildenafil Treatment in Heart Failure With Preserved Ejection Fraction: Targeted Metabolomic Profiling in the RELAX Trial

W. Kraus, K. Anstrom, Svati H Shah, 2017, JAMA cardiology.

Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.

Mahesh J. Patel, Svati H Shah, L. Svetkey, 2013, Omics : a journal of integrative biology.

Glucokinase gene transfer to skeletal muscle of diabetic Zucker fatty rats improves insulin-sensitive glucose uptake.

C. Newgard, J. Jiménez-Chillarón, A. Gómez-Foix, 2002, Metabolism: clinical and experimental.

A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation

L. G. Moss, C. Newgard, M. Arlotto, 2016, Molecular and Cellular Biology.

Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

Svati H Shah, C. Newgard, J. Bain, 2021, Molecular metabolism.

Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys

O. Ilkayeva, C. Newgard, D. McClain, 2019, Frontiers in neuroscience.

Branched-chain amino acids in disease

C. Newgard, P. White, 2019, Science.

Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure

Christoph D. Rau, Svati H Shah, X. Xiao, 2016, Circulation.

Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism

O. Ilkayeva, C. Newgard, A. Olson, 2016, Diabetes.

The metabolic phenotype of Prader-Willi syndrome (PWS) in childhood: heightened insulin sensitivity relative to body mass index.

S. Grambow, C. Newgard, M. Muehlbauer, 2010, The Journal of clinical endocrinology and metabolism.

Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins.

C. Kahn, B. Gibson, J. Meyer, 2019, Cell metabolism.

Critical Role of Type III Interferon in Controlling SARS-CoV-2 Infection in Human Intestinal Epithelial Cells

Michael E. Miller, Lindsay C. Page, Kevin S. Smith, 2020, Cell Reports.

Overexpression of Rat Long Chain Acyl-CoA Synthetase 1 Alters Fatty Acid Metabolism in Rat Primary Hepatocytes*

R. Coleman, C. Newgard, D. Mashek, 2006, Journal of Biological Chemistry.

Association of lipid profile biomarkers with breast cancer by molecular subtype: analysis of the MEND study

T. Akinyemiju, C. Newgard, M. Muehlbauer, 2022, Scientific reports.

Association of high-sensitivity C-reactive protein and odds of breast cancer by molecular subtype: analysis of the MEND study

T. Akinyemiju, D. Arnett, C. Newgard, 2021, Oncotarget.

An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans.

C. Newgard, J. Schisler, J. Bain, 2004, Diabetes.

Expression and glycogenic effect of glycogen-targeting protein phosphatase 1 regulatory subunit GL in cultured human muscle.

C. Lerin, C. Newgard, C. Garcı́a-Martı́nez, 2007, The Biochemical journal.

Protein synthesis. The perks of balancing glucose.

N. Sonenberg, C. Newgard, 2001, Science.

The Perks of Balancing Glucose

N. Sonenberg, C. Newgard, 2001, Science.

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose

Matthew J. Rardin, C. Kahn, B. Gibson, 2018, PloS one.

Multi-Omic Profiling Reveals the Opposing Forces of Excess Dietary Sugar and Fat on Liver Mitochondria Protein Acetylation and Succinylation

Matthew J. Rardin, C. Kahn, B. Gibson, 2018, bioRxiv.

Pathogenesis of A 2 b + Ketosis-Prone Diabetes

C. Newgard, C. Hampe, J. Bain, 2013 .

Pathogenesis of A−β+ Ketosis-Prone Diabetes

C. Newgard, C. Hampe, J. Bain, 2013, Diabetes.

Substrate Control of Insulin Release

C. Newgard, F. Matschinsky, 2011 .

Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function.

C. Newgard, R. Unger, Y. Lee, 1999, Diabetes.

Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism.

J. H. Johnson, C. Newgard, John H. Johnson, 1993, The Journal of biological chemistry.

De novo lipogenesis fuels adipocyte autophagosome membrane dynamics

O. Ilkayeva, C. Newgard, M. Czech, 2022, bioRxiv.

Muscle ring finger-3 protects against diabetic cardiomyopathy induced by a high fat diet

C. Newgard, J. Schisler, Joseph A. Hill, 2015, BMC Endocrine Disorders.

Metabolomic Quantitative Trait Loci (mQTL) Mapping Implicates the Ubiquitin Proteasome System in Cardiovascular Disease Pathogenesis

W. Kraus, Svati H Shah, S. Gregory, 2015, PLoS genetics.

Insulin Resistance Takes a Trip Through the ER

C. Newgard, D. Muoio, 2004, Science.

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling.

C. Kahn, T. N. Rao, O. Ilkayeva, 2018, The Journal of clinical investigation.

Divergent effects of glucose and fructose on hepatic lipogenesis and insulin signaling

C. Kahn, T. N. Rao, O. Ilkayeva, 2017, The Journal of clinical investigation.

Pancreatic islets and insulinoma cells express a novel isoform of group VIA phospholipase A2 (iPLA2 beta) that participates in glucose-stimulated insulin secretion and is not produced by alternate splicing of the iPLA2 beta transcript.

S. Zhang, C. Newgard, G. A. Grant, 2003, Biochemistry.

Perspectives in Diabetes While Tinkering With the P-Cell . . . Metabolic Regulatory Mechanisms and New Therapeutic Strategies American Diabetes Association Lilly Lecture , 2001

C. Newgard, 2022 .

Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.

K. Murray, C. Newgard, A. Hishiya, 2016, The American journal of pathology.

Differential Metabolic Effects of Adenovirus-mediated Glucokinase and Hexokinase I Overexpression in Rat Primary Hepatocytes*

C. Newgard, J. Guinovart, A. Gómez-Foix, 1996, The Journal of Biological Chemistry.

Suppression of beta cell energy metabolism and insulin release by PGC-1alpha.

P. Puigserver, B. Spiegelman, B. Lowell, 2003, Developmental cell.

Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model

M. Dewhirst, S. Pizzo, S. Freedland, 2017, The Prostate.

Metabolism: A is for adipokine

C. Newgard, D. Muoio, 2005, Nature.

Cellular Engineering for the Treatment of Metabolic Disorders: Prospects for Therapy in Diabetes

C. Newgard, 1992, Bio/Technology.

Altered distribution of adiponectin isoforms in children with Prader–Willi syndrome (PWS): association with insulin sensitivity and circulating satiety peptide hormones

S. Grambow, L. Svetkey, C. Newgard, 2007, Clinical endocrinology.

Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition.

C. Newgard, K. Bornfeldt, R. O’Doherty, 1999, American journal of physiology. Endocrinology and metabolism.

Sparing effect of leptin on liver glycogen stores in rats during the fed-to-fasted transition.

C. Newgard, K. Bornfeldt, R. O’Doherty, 1999, The American journal of physiology.

A tribute to Roger H. Unger (1924-2020).

C. Newgard, P. Scherer, 2020, The Journal of clinical investigation.

Reversing adipocyte differentiation: implications for treatment of obesity.

C. Newgard, R. Unger, Y. T. Zhou, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.

D. Mangelsdorf, C. Newgard, R. Unger, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Increased insulin sensitivity in mice lacking collectrin, a downstream target of HNF-1alpha.

C. Newgard, D. Muoio, Danhong Lu, 2009, Molecular endocrinology.

A Glucose-to-Gene Link

C. Newgard, J. Rathmell, 2009, Science.

The Repression of Hormone-activated PEPCK Gene Expression by Glucose Is Insulin-independent but Requires Glucose Metabolism*

C. Newgard, D. Scott, D. Granner, 1998, The Journal of Biological Chemistry.

Glucose Activates Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase) through Proline-rich Tyrosine Kinase-2 and the Glut1 Glucose Transporter*

M. Quon, C. Newgard, I. Dikic, 2000, The Journal of Biological Chemistry.

Diabetes: The good in fat

C. Newgard, D. Muoio, 2014, Nature.

John Denis McGarry, PhD: A Remembrance of a Master Metabolic Physiologist

C. Newgard, 2018, Diabetes Care.

Overexpression of the P46 (T1) Translocase Component of the Glucose-6-phosphatase Complex in Hepatocytes Impairs Glycogen Accumulation via Hydrolysis of Glucose 1-Phosphate*

C. Newgard, J. An, G. van de Werve, 2001, The Journal of Biological Chemistry.

Differential Effects of Overexpressed Glucokinase and Hexokinase I in Isolated Islets

C. Newgard, G. Bell, T. Becker, 1996, The Journal of Biological Chemistry.

Evidence for Suppression of Hepatic Glucose-6-Phosphatase with Carbohydrate Feeding

C. Newgard, J. McGarry, D. W. Foster, 1984, Diabetes.

Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats.

C. Newgard, J. McGarry, M. Kuwajima, 1984, The Journal of clinical investigation.

Adenovirus-mediated Overexpression of Liver 6-Phosphofructo-2-kinase/Fructose-2,6-bisphosphatase in Gluconeogenic Rat Hepatoma Cells

C. Newgard, A. Lange, T. Becker, 1995, The Journal of Biological Chemistry.

The glucose-phosphorylating capacity of liver as measured by three independent assays. Implications for the mechanism of hepatic glycogen synthesis.

C. Newgard, J. McGarry, M. Kuwajima, 1986, The Journal of biological chemistry.

Restoration of Hepatic Glucokinase Expression Corrects Hepatic Glucose Flux and Normalizes Plasma Glucose in Zucker Diabetic Fatty Rats

R. Printz, C. Newgard, M. Shiota, 2009, Diabetes.

Fasting-induced hepatic production of DHEA is regulated by PGC-1alpha, ERRalpha, and HNF4alpha.

M. Dwyer, L. Grasfeder, O. Ilkayeva, 2009, Molecular endocrinology.

Resistance to adenovirally induced hyperleptinemia in rats. Comparison of ventromedial hypothalamic lesions and mutated leptin receptors.

C. Newgard, M. G. Dube, S. Kalra, 1998, The Journal of clinical investigation.

Cholinergic Augmentation of Insulin Release Requires Ankyrin-B

C. Newgard, P. Berggren, J. Hoffman, 2010, Science Signaling.

Exercise-Induced Changes in Metabolic Intermediates, Hormones, and Inflammatory Markers Associated With Improvements in Insulin Sensitivity

W. Kraus, C. Newgard, C. Slentz, 2010, Diabetes Care.

Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production.

C. Newgard, R. Davis, V. V. Tran, 1998, The Journal of clinical investigation.

OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype.

C. Newgard, R. Unger, K. Koyama, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Regulation and function of the muscle glycogen-targeting subunit of protein phosphatase 1 (GM) in human muscle cells depends on the COOH-terminal region and glycogen content.

C. Newgard, M. Brady, C. Clark, 2003, Diabetes.

Regulation of Insulin Secretion From Novel Engineered Insulinoma Cell Lines

C. Newgard, K. Normington, K. Normington, 1997, Diabetes.

Mechanism of insulin Gene Regulation by the Pancreatic Transcription Factor Pdx-1

G. Weir, C. Newgard, J. Schisler, 2005, Journal of Biological Chemistry.

Metabolic Mechanisms and Diabetes Candidate Genes: Insights Gained from Genetic Engineering with Recombinant Adenoviruses

H. Berman, C. Newgard, R. Gasa, 2000 .

Glucokinase Overexpression Restores Glucose Utilization and Storage in Cultured Hepatocytes from Male Zucker Diabetic Fatty Rats*

C. Newgard, J. Guinovart, A. Barberà, 1999, The Journal of Biological Chemistry.

Metabolic Impact of Adenovirus-mediated Overexpression of the Glucose-6-phosphatase Catalytic Subunit in Hepatocytes*

C. Newgard, J. Guinovart, A. Lange, 1997, The Journal of Biological Chemistry.

Chronic Suppression of Acetyl-CoA Carboxylase 1 in β-Cells Impairs Insulin Secretion via Inhibition of Glucose Rather Than Lipid Metabolism*

O. Ilkayeva, C. Newgard, S. Ronnebaum, 2008, Journal of Biological Chemistry.

Lipoapoptosis in Beta-cells of Obese Prediabeticfa/fa Rats

C. Newgard, R. Unger, May-yun Wang, 1998, Journal of Biological Chemistry.

Engineering of glucose-stimulated insulin secretion and biosynthesis in non-islet cells.

J. H. Johnson, C. Newgard, John H. Johnson, 1992, Proceedings of the National Academy of Sciences of the United States of America.

The effect of a HFD on mitochondrial metabolism depends on nutritional state and mTORC1 activation

J. Brugarolas, O. Ilkayeva, C. Newgard, 2016 .

Cardiomyocyte glucagon receptor signaling modulates outcomes in mice with experimental myocardial infarction

D. Drucker, O. Ilkayeva, C. Newgard, 2014, Molecular metabolism.

Glucokinase and glucose transporter expression in liver and islets: implications for control of glucose homoeostasis.

C. Newgard, J. Milburn, S. Hughes, 1990, Biochemical Society transactions.

Regulation of beta-cell glucose transporter gene expression.

J. H. Johnson, C. Newgard, R. Unger, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Evidence that down-regulation of beta-cell glucose transporters in non-insulin-dependent diabetes may be the cause of diabetic hyperglycemia.

J. H. Johnson, L. Orci, C. Newgard, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage.

C. Newgard, J. Guinovart, A. Gómez-Foix, 1998, Diabetes.

1 Fenofibrate Induced Cardiac Fibrosis in Mice 2 Deficient in the Protein Quality Control Regulator , 3 CHIP 4

O. Ilkayeva, C. Newgard, C. Patterson, 2018 .

Adverse Effects of Fenofibrate in Mice Deficient in the Protein Quality Control Regulator, CHIP

O. Ilkayeva, C. Newgard, J. Schisler, 2018, Journal of cardiovascular development and disease.

Hepatic Overexpression of Glycerol-sn-3-phosphate Acyltransferase 1 in Rats Causes Insulin Resistance*

Shuli Wang, R. Coleman, G. Shulman, 2007, Journal of Biological Chemistry.

Recommendations for Improving Identification and Quantification in Non-Targeted, GC-MS-Based Metabolomic Profiling of Human Plasma

Svati H Shah, E. Hauser, C. Newgard, 2017, Metabolites.

A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.

C. Newgard, J. Schisler, J. An, 2012, Cell metabolism.

Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women.

W. Kraus, E. Ravussin, L. Redman, 2011, The Journal of clinical endocrinology and metabolism.

Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells.

C. Newgard, A. Karasik, R. Seijffers, 1999, Endocrinology.

Control of Voltage-gated Potassium Channel Kv2.2 Expression by Pyruvate-Isocitrate Cycling Regulates Glucose-stimulated Insulin Secretion*

M. Jensen, C. Newgard, Danhong Lu, 2013, The Journal of Biological Chemistry.

The polymorphic locus for glycogen storage disease VI (liver glycogen phosphorylase) maps to chromosome 14.

R. Fletterick, C. Newgard, R. Lebo, 1987, American journal of human genetics.

Postprandial Metabolite Profiles Reveal Differential Nutrient Handling After Bariatric Surgery Compared With Matched Caloric Restriction

C. Newgard, C. Khoo, M. Muehlbauer, 2014, Annals of surgery.

Plasma acylcarnitines are associated with pulmonary hypertension

W. Kraus, Svati H Shah, O. Ilkayeva, 2017, Pulmonary circulation.

Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis.

O. Ilkayeva, C. Newgard, Vinesh Vinayachandran, 2021, The Journal of clinical investigation.

Trefoil factor 3 stimulates human and rodent pancreatic islet beta-cell replication with retention of function.

C. Newgard, J. Schisler, R. Mirmira, 2008, Molecular endocrinology.

Pro- and Antiapoptotic Proteins Regulate Apoptosis but Do Not Protect Against Cytokine-Mediated Cytotoxicity in Rat Islets and β-Cell Lines

C. Newgard, P. Fueger, J. Collier, 2006, Diabetes.

Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non‐targeted metabolomics analysis

C. Newgard, B. Jensen, C. Patterson, 2017, British journal of pharmacology.

Adenovirus-mediated transfer of the muscle glycogen phosphorylase gene into hepatocytes confers altered regulation of glycogen metabolism.

C. Newgard, R. Gerard, A. Gómez-Foix, 1992, The Journal of biological chemistry.

Structural Relationships in Glycogen Phosphorylases a

R. Fletterick, P. Hwang, C. Newgard, 1986, Annals of the New York Academy of Sciences.

Developmental expression of glycogenolytic enzymes in rabbit tissues: possible relationship to fetal lung maturation.

R. Frenkel, C. Newgard, F. Martiniuk, 1991, Biochimica et biophysica acta.

Human brain glycogen phosphorylase. Cloning, sequence analysis, chromosomal mapping, tissue expression, and comparison with the human liver and muscle isozymes.

R. Fletterick, C. Newgard, D. Littman, 1988, The Journal of biological chemistry.

Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells.

C. Newgard, J. Milburn, S. Hughes, 1991, The Journal of biological chemistry.

Glucose 6-Phosphate Produced by Glucokinase, but Not Hexokinase I, Promotes the Activation of Hepatic Glycogen Synthase*

C. Newgard, J. Guinovart, R. O’Doherty, 1996, The Journal of Biological Chemistry.

Expression of the Transcription Factor STAT-1α in Insulinoma Cells Protects against Cytotoxic Effects of Multiple Cytokines*

C. Newgard, Guoxun Chen, G. Chen, 2001, The Journal of Biological Chemistry.

Pdx-1 Activates Islet α- and β-Cell Proliferation via a Mechanism Regulated by Transient Receptor Potential Cation Channels 3 and 6 and Extracellular Signal-Regulated Kinases 1 and 2

L. G. Moss, C. Newgard, J. Schisler, 2013, Molecular and Cellular Biology.

Adenovirus-mediated Expression of the Catalytic Subunit of Glucose-6-phosphatase in INS-1 Cells

C. Newgard, A. Lange, R. O’Doherty, 1997, The Journal of Biological Chemistry.

Engineering of Glycerol-stimulated Insulin Secretion in Islet Beta Cells

C. Newgard, J. McGarry, P. Antinozzi, 1997, The Journal of Biological Chemistry.

Normal Flux through ATP-Citrate Lyase or Fatty Acid Synthase Is Not Required for Glucose-stimulated Insulin Secretion*

C. Newgard, S. Ronnebaum, S. Burgess, 2007, Journal of Biological Chemistry.

Mitochondrial Metabolism Sets the Maximal Limit of Fuel-stimulated Insulin Secretion in a Model Pancreatic Beta Cell

C. Newgard, C. Wollheim, H. Ishihara, 2002, The Journal of Biological Chemistry.

Physiological mechanisms of sustained fumagillin-induced weight loss.

T. Hughes, J. Gordon, O. Ilkayeva, 2018, JCI insight.

Elevated hepatic fatty acid elongase‐5 (Elovl5) attenuates fatty liver in high fat diet induced obese mice

C. Newgard, J. Bain, R. Stevens, 2013 .

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo

C. Newgard, J. Schisler, J. Bain, 2016, Metabolomics.

The Role of Voltage-Gated Potassium Channels Kv2.1 and Kv2.2 in the Regulation of Insulin and Somatostatin Release from Pancreatic Islets

M. Jensen, C. Newgard, Yun-ping Zhou, 2013, The Journal of Pharmacology and Experimental Therapeutics.

Engineered cell lines for insulin replacement in diabetes: current status and future prospects

C. Newgard, K. Normington, H. Beltrandelrio, 1997, Diabetologia.

Molecular Engineering of Glucose-Regulated Insulin Secretion

C. Newgard, John H. Johnson, S. Ferber, 1994 .

Expression of reg/PSP, a pancreatic exocrine gene: relationship to changes in islet beta-cell mass.

C. Newgard, T. Alam, R. Unger, 1991, Molecular endocrinology.

Paradoxical activation of transcription factor SREBP1c and de novo lipogenesis by hepatocyte-selective ATP-citrate lyase depletion in obese mice

Lawrence M. Lifshitz, Xianlin Han, R. Friedline, 2022, The Journal of biological chemistry.

Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.

Philipp W. Raess, A. Attie, B. K. Presley, 2008, Molecular endocrinology.

STZ Transport and Cytotoxicity: Specific Enhancement in GLUT2-Expressing Cells

C. Newgard, John H. Johnson, W. Schnedl, 1994, Diabetes.

Autoantibodies to the GLUT-2 glucose transporter of beta cells in insulin-dependent diabetes mellitus of recent onset.

J. H. Johnson, C. Newgard, R. Unger, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Erratum: Underexpression of β cell high K(m) glucose transporters in noninsulin-dependent diabetes (Science (26 Oct. 1990) (546))

L. Orci, C. Newgard, R. Unger, 1990 .

Factors regulating islet regeneration in the post-insulinoma NEDH rat.

C. Newgard, R. Unger, C. Miyaura, 1992, Advances in experimental medicine and biology.

Cellular Engineering and Gene Therapy Strategies for Insulin Replacement in Diabetes

C. Newgard, 1994, Diabetes.

Nkx6.1 regulates islet β-cell proliferation via Nr4a1 and Nr4a3 nuclear receptors

L. G. Moss, M. Jensen, C. Newgard, 2014, Proceedings of the National Academy of Sciences.

GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.

J. H. Johnson, C. Newgard, T. Becker, 1994, The Journal of biological chemistry.

Heterogeneity of somatostatin like immunoreactivity (SLI) in extracts of porcine, canine and human pancreas.

C. Newgard, J. Holst, 1981, Acta endocrinologica.

Pancreatic -Cells in Obesity

C. Newgard, R. Unger, H. Hirose, 1995, The Journal of Biological Chemistry.

Increased Insulin Sensitivity in Mice Lacking Collectrin, a Downstream Target of HNF-1 (cid:1)

C. Newgard, D. Muoio, Danhong Lu, 2009 .

Functional Genomics of the -Cell: Short-Chain 3- Hydroxyacyl-Coenzyme A Dehydrogenase Regulates Insulin Secretion Independent of K Currents

K. Kaestner, C. Stoeckert, P. White, 2006 .

Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note.

Philipp W. Raess, A. Attie, B. K. Presley, 2010, Molecular endocrinology.

Effect of Heparin Administration on Metabolomic Profiles in Samples Obtained During Cardiac Catheterization

Michael P. Brunner, W. Kraus, C. Granger, 2011, Circulation. Cardiovascular genetics.

Metabolomic Profiling of the Effects of Dapagliflozin in Heart Failure With Reduced Ejection Fraction: DEFINE-HF

Svati H Shah, B. Scirica, S. Selvaraj, 2022, Circulation.

The role of AMPK and mTOR in nutrient sensing in pancreatic beta-cells.

M. Birnbaum, C. Newgard, L. Witters, 2007, The Journal of biological chemistry.

Lower brain-derived neurotrophic factor in patients with prader-willi syndrome compared to obese and lean control subjects.

C. Newgard, M. Muehlbauer, A. Haqq, 2010, The Journal of clinical endocrinology and metabolism.

Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes

C. Newgard, J. Bain, M. Muehlbauer, 2014, Metabolomics.

McNulty Microbiome of Gnotobiotic Mice and Monozygotic Twins The Impact of a Consortium of Fermented Milk Strains on the Gut

R. Knight, J. Faith, Tanya Yatsunenko, 2011 .

Tirzepatide induces a thermogenic-like amino acid signature in brown adipose tissue

V. Pirro, O. Ilkayeva, C. Newgard, 2022, Molecular metabolism.

Snare protein expression and adenoviral transfection of amphicrine AR42J.

C. Newgard, W. Trimble, L. Sheu, 1999, Biochemical and biophysical research communications.

Diminished Acyl-CoA Synthetase Isoform 4 Activity in INS 832/13 Cells Reduces Cellular Epoxyeicosatrienoic Acid Levels and Results in Impaired Glucose-stimulated Insulin Secretion*

R. Coleman, O. Ilkayeva, C. Newgard, 2013, The Journal of Biological Chemistry.

Metabolomic profile associated with insulin resistance and conversion to diabetes in the Insulin Resistance Atherosclerosis Study.

Nicholette D. Palmer, R. Bergman, N. Palmer, 2015, The Journal of clinical endocrinology and metabolism.

distinct glucose-responsive regions subunit of rat glucose-6-phosphatase contains two The promoter for the gene encoding the catalytic

J. Haycock, C. Newgard, D. Scott, 2007 .

Inflammatory mechanisms in diabetes: lessons from the beta-cell.

C. Newgard, R. Gasa, H. Hohmeier, 2003, International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.

BMI, RQ, Diabetes, and Sex Affect the Relationships Between Amino Acids and Clamp Measures of Insulin Action in Humans

Olga Ilkayeva, Christopher B. Newgard, O. Ilkayeva, 2014, Diabetes.

FoxA2, Nkx2.2, and PDX-1 Regulate Islet β-Cell-Specific mafA Expression through Conserved Sequences Located between Base Pairs −8118 and −7750 Upstream from the Transcription Start Site

L. Sussel, I. Artner, R. Stein, 2006, Molecular and Cellular Biology.

Type-2-Diabetes Alters CSF but Not Plasma Metabolomic and AD Risk Profiles in Vervet Monkeys

O. Ilkayeva, C. Newgard, D. McClain, 2019, bioRxiv.

Fatty Acid Oxidation and Insulin Action

C. Newgard, D. Muoio, 2008, Diabetes.

Gαz Negatively Regulates Insulin Secretion and Glucose Clearance*

P. Casey, C. Newgard, C. Bailey, 2008, Journal of Biological Chemistry.

Understanding of basic mechanisms of β-cell function and survival

M. Jensen, C. Newgard, Guoxun Chen, 2004, Cell Biochemistry and Biophysics.

Metabolic Profiles Predict Adverse Events Following Coronary Artery Bypass Grafting

W. Kraus, C. Granger, E. Hauser, 2012 .

13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS)

H. Mulder, M. Jensen, C. Newgard, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Overexpression of a Modified Human Malonyl-CoA Decarboxylase Blocks the Glucose-induced Increase in Malonyl-CoA Level but Has No Impact on Insulin Secretion in INS-1-derived (832/13) β-Cells*

H. Mulder, C. Newgard, Danhong Lu, 2001, The Journal of Biological Chemistry.

Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity.

C. Newgard, R. Gasa, V. V. Tran, 2000, Diabetes.

Molecular engineering of the pancreatic beta-cell.

C. Newgard, S. Ferber, H. Beltrandelrio, 1993, The Journal of laboratory and clinical medicine.

Glucose-stimulated Insulin Secretion and Results in Impaired Cellular Epoxyeicosatrienoic Acid Levels Activity in INS 832 / 13 Cells Reduces Diminished Acyl-CoA Synthetase Isoform 4 Lipids :

R. Coleman, O. Ilkayeva, C. Newgard, 2013 .

The liver--a potential new player in islet regeneration?

L. G. Moss, C. Newgard, 2009, Cell metabolism.

Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy.

Xian Chen, S. Hilsenbeck, B. O’Malley, 2012, Cell metabolism.

Regulation of mitochondrial morphology by APC/CCdh1-mediated control of Drp1 stability

O. Ilkayeva, C. Newgard, J. Rathmell, 2011, Molecular biology of the cell.

Exercise-induced changes in metabolic intermediates, hormones, and inflammatory markers associated with improvements in insulin sensitivity Short Title: Exercise Training-Induced Changes in Metabolites

C. Newgard, C. Slentz, K. Huffman, 2010 .

Association of a Peripheral Blood Metabolic Profile With Coronary Artery Disease and Risk of Subsequent Cardiovascular Events

Geoffrey S Ginsburg, Elizabeth R Hauser, William E Kraus, 2010, Circulation. Cardiovascular genetics.

Rat amylin: cloning and tissue-specific expression in pancreatic islets.

C. Newgard, K. Luskey, H. Okamoto, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Effect of Caloric Restriction with and without Exercise on Metabolic Intermediates in Nonobese Men and Women.

W. Kraus, E. Ravussin, L. Redman, 2011, Endocrinology.

Glucose down-regulates the expression of the peroxisome proliferator-activated receptor-alpha gene in the pancreatic beta -cell.

M. Prentki, C. Newgard, E. Roche, 2000, The Journal of biological chemistry.

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

David Millington, G. Shulman, G. Cline, 2004, Nature Medicine.

KLF15 controls brown adipose tissue transcriptional flexibility and metabolism in response to various energetic demands

O. Ilkayeva, C. Newgard, Vinesh Vinayachandran, 2022, iScience.

The PanK2 Genes of Mouse and Human Specify Proteins with DistinctSubcellular Locations

C. Rock, O. Ilkayeva, C. Newgard, 2007 .

The PanK 2 Genes of Mouse and Human Specify Proteins 1 with Distinct Subcellular Locations 2 3

C. Newgard, J. Bain, Yong-mei Zhang, 2007 .

Role of peroxisome proliferator-activated receptor alpha in disease of pancreatic beta cells.

C. Newgard, R. Unger, Y. Lee, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras.

C. Newgard, L. E. Noel, 1997, Biochemistry.

Islets for all?

C. Newgard, H. Hohmeier, 2005, Nature Biotechnology.

Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

M. Prentki, H. Mulder, C. Newgard, 2000, Diabetes.

Selection of Insulinoma Cell Lines With Resistance to Interleukin-1 - and

C. Newgard, Guoxun Chen, R. Gasa, 2000 .

Metabolic Profiling for Understanding of Diabetes and Obesity Mechanisms

C. Newgard, S. W. Stedman, 2006 .

Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

Christoph Handschin, Jiandie D. Lin, Bruce M. Spiegelman, 2005, Cell.

Liver receptor homolog‐1 is a critical determinant of methyl‐pool metabolism

J. Borén, D. Moore, C. Newgard, 2016, Hepatology.

Ildr1 gene deletion protects against diet-induced obesity and hyperglycemia

Dipendra K. Aryal, W. Wetsel, C. Newgard, 2022, PloS one.

Circadian Clock NAD+ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

J. Denu, N. Chandel, O. Ilkayeva, 2013, Science.

Bioenergetic Analysis of Peroxisome Proliferator-activated Receptor γ Coactivators 1α and 1β (PGC-1α and PGC-1β) in Muscle Cells*

Jiandie D. Lin, Paul T. Tarr, B. Spiegelman, 2003, Journal of Biological Chemistry.

Improvement in insulin resistance after gastric bypass surgery is correlated with a decline in plasma 2-hydroxybutyric acid.

L. Svetkey, O. Ilkayeva, C. Newgard, 2018, Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery.

Moderate dietary vitamin B-6 restriction raises plasma glycine and cystathionine concentrations while minimally affecting the rates of glycine turnover and glycine cleavage in healthy men and women.

J. Gregory, E. Quinlivan, C. Newgard, 2009, The Journal of nutrition.

Modeling the biochemical differences between rabbit muscle and human liver phosphorylase

R J Fletterick, S R Sprang, S. Sprang, 1987, Proteins.

Daily variation of serum acylcarnitines and amino acids

C. Pieper, C. Newgard, J. Bain, 2012, Metabolomics.

Non-targeted metabolomics of Brg1/Brm double-mutant cardiomyocytes reveals a novel role for SWI/SNF complexes in metabolic homeostasis

C. Newgard, J. Bain, M. Muehlbauer, 2015, Metabolomics.

Non-targeted metabolomics analysis of cardiac Muscle Ring Finger-1 (MuRF1), MuRF2, and MuRF3 in vivo reveals novel and redundant metabolic changes

C. Newgard, J. Bain, M. Muehlbauer, 2015, Metabolomics.

Use of recombinant adenovirus for metabolic engineering of mammalian cells.

C. Newgard, T. Alam, R. Gerard, 1994, Methods in cell biology.

Effects of Modulation of Glycerol Kinase Expression on Lipid and Carbohydrate Metabolism in Human Muscle Cells*

C. Newgard, A. Gómez-Foix, C. Lerín, 2002, The Journal of Biological Chemistry.

Adenovirus-mediated delivery into myocytes of muscle glycogen phosphorylase, the enzyme deficient in patients with glycogen-storage disease type V.

C. Newgard, J. Guinovart, R. Gerard, 1994, The Biochemical journal.

Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress

L. Boros, J. Chi, O. Ilkayeva, 2013, Cancer & metabolism.

Daily variation of serum acylcarnitines and amino acids

C. Newgard, J. Bain, R. Stevens, 2011, Metabolomics.

The family of glycogen phosphorylases: structure and function.

R. Fletterick, P. Hwang, C. Newgard, 1989, Critical reviews in biochemistry and molecular biology.

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

S. Levy, R. Stein, K. Vickers, 2017, Cell metabolism.

Metabolomic Analysis Reveals Extended Metabolic Consequences of Marginal Vitamin B-6 Deficiency in Healthy Human Subjects

Dean P. Jones, Tamer Kahveci, S. Ranka, 2013, PloS one.

Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia.

C. Newgard, R. O’Doherty, D. Lehman, 1999, Diabetes.

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

Olga Ilkayeva, O. Ilkayeva, C. Newgard, 2008, Cell metabolism.

Differential expression and regulation of the glucokinase gene in liver and islets of Langerhans.

C. Ucla, C. Newgard, T. Nouspikel, 1989, Proceedings of the National Academy of Sciences of the United States of America.

The Impact of a Consortium of Fermented Milk Strains on the Gut Microbiome of Gnotobiotic Mice and Monozygotic Twins

Bernard Henrissat, Rob Knight, Dan Knights, 2011, Science Translational Medicine.

Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis.

C. Rock, O. Ilkayeva, C. Newgard, 2007, Chemistry & biology.

Mechanisms controlling pancreatic islet cell function in insulin secretion

C. Newgard, Jonathan E. Campbell, 2021, Nature Reviews Molecular Cell Biology.

Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites1

Matthew S. Cook, C. Newgard, J. Gooding, 2015, Biology of reproduction.

Sialylated Milk Oligosaccharides Promote Microbiota-Dependent Growth in Models of Infant Undernutrition

Michael J. Barratt, J. Gordon, M. Talcott, 2016, Cell.

Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children

Michael J. Barratt, A. Osterman, B. Henrissat, 2016, Science.

The Gut Microbiota Modulates Energy Metabolism in the Hibernating Brown Bear Ursus arctos.

Ole Fröbert, Jonas Kindberg, Felix Sommer, 2016, Cell reports.

Dissecting the in Vivo Metabolic Potential of Two Human Gut Acetogens

J. Faith, J. Gordon, C. Newgard, 2010, The Journal of Biological Chemistry.

Peroxisome Proliferator-activated Receptor-γ Co-activator 1α-mediated Metabolic Remodeling of Skeletal Myocytes Mimics Exercise Training and Reverses Lipid-induced Mitochondrial Inefficiency*

Ping Li, Olga Ilkayeva, O. Ilkayeva, 2005, Journal of Biological Chemistry.

Ubiquitin Fold Modifier 1 (UFM1) and Its Target UFBP1 Protect Pancreatic Beta Cells from ER Stress-Induced Apoptosis

M. Granvik, M. Igoillo-Esteve, M. Cnop, 2011, PloS one.

Metabolomics and Metabolic Diseases: Where Do We Stand?

C. Newgard, Christopher B Newgard, 2017, Cell metabolism.

Association of Lipid Profile Biomarkers with Breast Cancer by Molecular Subtype: analysis of the Mechanisms for Established and Novel Risk Factors for Breast Cancer in Women of African Descent (MEND) study

T. Akinyemiju, D. Arnett, C. Newgard, 2021 .

Sr Proteins in Microrna/mrna Biogenesis

B. Hogan, C. Newgard, Jun Zhu, 2022 .

Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing

C. Newgard, D. Muoio, M. Arlotto, 2018, Nucleic acids research.

A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase Regulates Glucose-stimulated Insulin Secretion*

M. Jensen, O. Ilkayeva, C. Newgard, 2006, Journal of Biological Chemistry.

Metabolomics applied to the pancreatic islet.

Jessica R Gooding, M. Jensen, C. Newgard, 2016, Archives of biochemistry and biophysics.

Getting biological about the genetics of diabetes

A. Attie, C. Newgard, Christopher B Newgard, 2010, Nature Medicine.

Metabolic cycling in control of glucose-stimulated insulin secretion.

M. Jensen, C. Newgard, S. Ronnebaum, 2008, American journal of physiology. Endocrinology and metabolism.

Novel Insulinoma Cell Lines Produced by Iterative Engineering of GLUT2, Glucokinase, and Human Insulin Expression

P. Halban, C. Newgard, S. Ferber, 1997, Diabetes.

BCAA Supplementation in Mice with Diet-Induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis.

O. Ilkayeva, C. Newgard, B. Kahn, 2021, Endocrinology.

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

Matthew J. Rardin, Eric Verdin, Bradford W. Gibson, 2013, Cell metabolism.

Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High-Fat Diet

C. Newgard, M. Muehlbauer, L. Makowski, 2011, Obesity.

Metabolomic profiling identifies complex lipid species and amino acid analogues associated with response to weight loss interventions

Nathan A. Bihlmeyer, Neha J. Pagidipati, W. Kraus, 2021, PloS one.

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

Robert V Farese, M. Laakso, F. Alt, 2011, Molecular cell.

SIRT 3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

Robert V Farese, M. Laakso, F. Alt, 2011 .

Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

Guillaume Adelmant, Bruce M. Spiegelman, Jerry Donovan, 2001, Nature.

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation.

J. Locasale, O. Ilkayeva, C. Newgard, 2015, The Journal of clinical investigation.

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

R. Goldberg, C. Newgard, J. Bain, 2019, Scientific Reports.

C. Newgard, D. Muoio, 2006, Annual review of biochemistry.

Suppression of β Cell Energy Metabolism and Insulin Release by PGC-1α

P. Puigserver, B. Spiegelman, B. Lowell, 2003 .

Metabolism in Mice Gut Microbiota from Twins Discordant for Obesity Modulate

Muehlbauer, J. Clemente, L. Ursell, 2013 .

Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression.

C. Newgard, R. Unger, May-yun Wang, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Effects of HIV Infection on the Metabolic and Hormonal Status of Children with Severe Acute Malnutrition

J. Bartlett, C. Newgard, J. Bain, 2014, PloS one.

HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism

M. Dewhirst, D. Kirsch, T. Delaney, 2015, Radiation research.

Sirt3 Regulates Fatty Acid Oxidation via Reversible Enzyme Deacetylation Hhs Public Access Supplementary Material

Robert V Farese, F. Alt, C. Kahn, 2022 .

TRB3 Links the E3 Ubiquitin Ligase COP1 to Lipid Metabolism

J. Yates, R. Evans, Sherry L. Niessen, 2006, Science.

Metabolic coupling factors in pancreatic beta-cell signal transduction.

C. Newgard, J. McGarry, C. Newgard, 1995, Annual review of biochemistry.

Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease

P. Saha, B. O’Malley, D. Moore, 2008, Science.

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

M. Lindholm, E. Ortlund, Nicole R. Gay, 2023, bioRxiv.

Integrated metabolomics and genomics: systems approaches to biomarkers and mechanisms of cardiovascular disease.

C. Newgard, Svati H. Shah, S. Shah, 2015, Circulation. Cardiovascular genetics.

Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance.

Matthew J. Rardin, C. Kahn, B. Emanuelli, 2012, Cell metabolism.

Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation.

C. Newgard, R. Unger, Y. Lee, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Branched-chain amino acid levels are associated with improvement in insulin resistance with weight loss

Bryan C. Batch, S. Nelson, J. Hollis, 2012, Diabetologia.

From dietary glucose to liver glycogen: the full circle round.

C. Newgard, J. McGarry, J. Katz, 1987, Annual review of nutrition.

Proteomic Profiling Reveals Adaptive Responses to Surgical Myocardial Ischemia–Reperfusion in Hibernating Arctic Ground Squirrels Compared to Rats

M. A. Moseley, M. Podgoreanu, C. Newgard, 2016, Anesthesiology.

Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass*

P. Casey, C. Newgard, J. B. Moss, 2012, The Journal of Biological Chemistry.

SIRT 3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

Robert V Farese, F. Alt, C. Kahn, 2010 .

Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL.

E. Ravussin, J. Finlayson, L. Mandarino, 2010, Cell metabolism.

Mig-6 Plays a Critical Role in the Regulation of Cholesterol Homeostasis and Bile Acid Synthesis

L. D. White, Jae Hee Lee, O. Ilkayeva, 2012, PloS one.

Severe acute malnutrition in childhood: hormonal and metabolic status at presentation, response to treatment, and predictors of mortality.

J. Bartlett, C. Newgard, J. Bain, 2014, The Journal of clinical endocrinology and metabolism.

The Mitochondrial Citrate/Isocitrate Carrier Plays a Regulatory Role in Glucose-stimulated Insulin Secretion*

M. Jensen, O. Ilkayeva, C. Newgard, 2006, Journal of Biological Chemistry.

The STEDMAN project: biophysical, biochemical and metabolic effects of a behavioral weight loss intervention during weight loss, maintenance, and regain.

L. Svetkey, O. Ilkayeva, C. Newgard, 2009, Omics : a journal of integrative biology.

NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding

G. Barish, N. Chandel, O. Ilkayeva, 2021, Nature Metabolism.

Efficacy of metformin and fermentable fiber combination therapy in adolescents with severe obesity and insulin resistance: study protocol for a double-blind randomized controlled trial

H. Tun, Arya M. Sharma, J. Walter, 2021, Trials.

Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity

A. Lusis, M. Vohl, O. Ilkayeva, 2022, medRxiv.

Metabolomic Signatures and Metabolic Complications in Childhood Obesity

C. Newgard, P. G. Balikcioglu, 2018 .

Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short‐term high‐fat overfeeding

A. Vaag, C. Newgard, R. Ribel‐Madsen, 2016, Physiological reports.

Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism.

Richard D. Smith, W. Qian, O. Ilkayeva, 2014, Cell metabolism.

Sequence analysis of the cDNA encoding human liver glycogen phosphorylase reveals tissue-specific codon usage.

R. Fletterick, P. Hwang, C. Newgard, 1986, Proceedings of the National Academy of Sciences of the United States of America.

De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics

O. Ilkayeva, C. Newgard, M. Czech, 2023, Nature Communications.

MED13-dependent signaling from the heart confers leanness by enhancing metabolism in adipose tissue and liver

Chad E. Grueter, A. Bookout, E. Olson, 2014, EMBO molecular medicine.

Metabolomic Profiling Reveals Mitochondrial-Derived Lipid Biomarkers That Drive Obesity-Associated Inflammation

Melissa A. Troester, Thomas M. O'Connell, Michael J. Muehlbauer, 2012, PloS one.

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

P. McNamara, C. Newgard, S. Stephens, 2019, bioRxiv.

Coordinated Regulatory Variation Associated with Gestational Hyperglycemia Regulates Expression of the Novel Hexokinase HKDC1

Christopher D. Brown, Timothy E. Reddy, D. Scholtens, 2014, Nature Communications.

The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance.

Robert V Farese, R. Zechner, C. Newgard, 2012, Cell metabolism.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

P. MacDonald, X. Dai, M. Jensen, 2017, Diabetes.

Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion

D. Glower, J. Mathew, M. Podgoreanu, 2009, Circulation.

Rapid and Weight-Independent Improvement of Glucose Tolerance Induced by a Peptide Designed to Elicit Apoptosis in Adipose Tissue Endothelium

S. Woods, R. Seeley, M. Medvedovic, 2012, Diabetes.

Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion

M. Prentki, C. Newgard, J. McGarry, 1998, The Journal of Biological Chemistry.

Glucose Down-regulates the Expression of the Peroxisome Proliferator-activated Receptor-α Gene in the Pancreatic β-Cell*

M. Prentki, C. Newgard, E. Roche, 2000, The Journal of Biological Chemistry.

Reductive TCA cycle metabolism fuels glutamine- and glucose-stimulated insulin secretion.

M. Jensen, C. Newgard, Guo-Fang Zhang, 2020, Cell metabolism.

Silencing of Cytosolic or Mitochondrial Isoforms of Malic Enzyme Has No Effect on Glucose-stimulated Insulin Secretion from Rodent Islets*

D. Macneil, M. Jensen, O. Ilkayeva, 2008, Journal of Biological Chemistry.

Effect of Roux-en-Y Gastric Bypass and Laparoscopic Adjustable Gastric Banding on Branched-Chain Amino Acid Metabolism

S. Klein, O. Ilkayeva, C. Newgard, 2013, Diabetes.

Near-roadway air pollution exposure and altered fatty acid oxidation among adolescents and young adults - The interplay with obesity.

L. Chatzi, K. Berhane, E. Hauser, 2019, Environment international.

Metabolomic Profiling for the Identification of Novel Biomarkers and Mechanisms Related to Common Cardiovascular Diseases: Form and Function

William E. Kraus, Christopher B. Newgard, W. Kraus, 2012, Circulation.

Effects of Tirzepatide, a Dual GIP and GLP-1 RA, on Lipid and Metabolite Profiles in Subjects with Type 2 Diabetes.

V. Pirro, K. Duffin, C. Newgard, 2021, The Journal of clinical endocrinology and metabolism.

Metabolomics applied to islet nutrient sensing mechanisms

P. MacDonald, M. Ferdaoussi, X. Dai, 2017, Diabetes, obesity & metabolism.

Relationships Between Circulating Metabolic Intermediates and Insulin Action in Overweight to Obese, Inactive Men and Women

William E. Kraus, James R. Bain, Kim M. Huffman, 2009, Diabetes Care.

Plasma acylcarnitines are associated with physical performance in elderly men.

H. Cohen, W. Kraus, C. Pieper, 2011, The journals of gerontology. Series A, Biological sciences and medical sciences.

Hepatic mTORC1 Opposes Impaired Insulin Action to Control Mitochondrial Metabolism in Obesity.

J. Brugarolas, O. Ilkayeva, C. Newgard, 2016, Cell reports.

Direct antidiabetic effect of leptin through triglyceride depletion of tissues.

C. Newgard, Guoxun Chen, R. Unger, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Respiratory Capacity and Reserve Predict Cell Sensitivity to Mitochondria Inhibitors: Mechanism-Based Markers to Identify Metformin-Responsive Cancers

P. Casey, C. Newgard, W. Zhu, 2019, Molecular Cancer Therapeutics.

The ubiquitin ligase MuRF1 regulates PPARα activity in the heart by enhancing nuclear export via monoubiquitination

D. Lalush, C. Newgard, J. Schisler, 2015, Molecular and Cellular Endocrinology.

A futile metabolic cycle activated in adipocytes by antidiabetic agents

M. Lazar, M. Jensen, C. Newgard, 2002, Nature Medicine.

Muscle-Liver Trafficking of BCAA-Derived Nitrogen Underlies Obesity-Related Glycine Depletion.

Scott B. Crown, W. Kraus, O. Ilkayeva, 2020, Cell reports.

Maternal BMI and Glycemia Impact the Fetal Metabolome

D. Scholtens, O. Ilkayeva, C. Newgard, 2017, Diabetes Care.

Role of peroxisome proliferator-activated receptor α in disease of pancreatic β cells

C. Newgard, R. Unger, May-yun Wang, 1998 .

Basic Science for Clinicians Metabolomic Profiling for the Identification of Novel Biomarkers and Mechanisms Related to Common Cardiovascular Diseases Form and Function

William E. Kraus, Christopher B. Newgard, W. Kraus, 2012 .

Metabolomic Profiling Reveals a Role for Caspase-2 in Lipoapoptosis*

O. Ilkayeva, C. Newgard, S. Kornbluth, 2013, The Journal of Biological Chemistry.

Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver.

Robert V Farese, A. Hevener, C. Newgard, 2007, Cell metabolism.

Branched chain amino acids are novel biomarkers for discrimination of metabolic wellness.

Bryan C. Batch, L. Newby, L. Appel, 2013, Metabolism: clinical and experimental.

Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.

Raffi Bekeredjian, R. Shohet, C. Newgard, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Metabolomic profiling identifies complex lipid species associated with response to weight loss interventions

Nathan A. Bihlmeyer, Neha J. Pagidipati, W. Kraus, 2020, bioRxiv.

Metabolomic Profiling Identifies Novel Circulating Biomarkers of Mitochondrial Dysfunction Differentially Elevated in Heart Failure With Preserved Versus Reduced Ejection Fraction: Evidence for Shared Metabolic Impairments in Clinical Heart Failure

Jacob P. Kelly, W. Kraus, G. Felker, 2016, Journal of the American Heart Association.

Cardiovascular Metabolomics

Scott B. Crown, C. Newgard, Guo-Fang Zhang, 2018, Circulation research.

Baseline metabolomic profiles predict cardiovascular events in patients at risk for coronary artery disease.

W. Kraus, R. Califf, C. Granger, 2012, American heart journal.

Insulin Resistance and Altered Systemic Glucose Metabolism in Mice Lacking Nur77

Laurent Vergnes, Peter Tontonoz, Matthew J. Watt, 2009, Diabetes.

Caloric Restriction Alters the Metabolic Response to a Mixed-Meal: Results from a Randomized, Controlled Trial

W. Kraus, E. Ravussin, L. Redman, 2012, PloS one.

Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic β-Cells.

Jing Li, A. Attie, C. Newgard, 2015, Molecular endocrinology.

Fundamental metabolic differences between hepatocytes and islet beta-cells revealed by glucokinase overexpression.

H. Berman, C. Newgard, C. B. Newgard, 1998, Biochemistry.

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data

William L. Lowe, Robert Stevens, Denise M. Scholtens, 2017, BMC Bioinformatics.

Adenovirus‐Mediated Leptin Expression Normalises Hypertension Associated with Diet‐Induced Obesity

C. Newgard, J. An, W. Zhang, 2010, Journal of neuroendocrinology.

Beta-cell specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.

Brett S. Peterson, C. Newgard, S. Stephens, 2020, American journal of physiology. Endocrinology and metabolism.

Neuropeptide Y Gene Polymorphisms Confer Risk of Early-Onset Atherosclerosis

W. Kraus, G. Ginsburg, C. Granger, 2009, PLoS genetics.

The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.

P. B. Jensen, G. Weir, C. Newgard, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Metabolomic and genetic associations with insulin resistance in pregnancy

D. Scholtens, M. Hayes, O. Ilkayeva, 2020, Diabetologia.

Association of Life-Course Educational Attainment and Breast Cancer Grade in the MEND Study

T. Akinyemiju, C. Newgard, A. Ojo, 2021, Annals of global health.

The Pediatric Obesity Microbiome and Metabolism Study (POMMS): Methods, Baseline Data, and Early Insights

H. Dressman, O. Ilkayeva, C. Newgard, 2021, Obesity.

Branched-chain amino acids alter neurobehavioral function in rats.

E. Levin, O. Ilkayeva, C. Newgard, 2013, American journal of physiology. Endocrinology and metabolism.

Evidence for a Role of Glucose-induced Translocation of Glucokinase in the Control of Hepatic Glycogen Synthesis*

C. Newgard, J. Guinovart, L. Agius, 1996, The Journal of Biological Chemistry.

Metabolic Syndrome and Risk of Breast Cancer by Molecular Subtype: Analysis of the MEND Study

T. Akinyemiju, C. Newgard, M. Muehlbauer, 2021, Clinical breast cancer.

Cord Blood Metabolomics: Association With Newborn Anthropometrics and C-Peptide Across Ancestries.

D. Scholtens, O. Ilkayeva, C. Newgard, 2019, The Journal of clinical endocrinology and metabolism.

Recent Progress in Metabolic Signaling Pathways Regulating Aging and Life Span

C. Newgard, J. Pessin, 2014, The journals of gerontology. Series A, Biological sciences and medical sciences.

An engineered liver glycogen phosphorylase with AMP allosteric activation.

R. Fletterick, C. Newgard, M. Browner, 1991, The Journal of biological chemistry.

The high Km glucose transporter of islets of Langerhans is functionally similar to the low affinity transporter of liver and has an identical primary sequence.

J. H. Johnson, H. Lodish, C. Newgard, 1990, The Journal of biological chemistry.

Stimulus/secretion coupling factors in glucose-stimulated insulin secretion: insights gained from a multidisciplinary approach.

M. Jensen, C. Newgard, Danhong Lu, 2002, Diabetes.

While tinkering with the beta-cell...metabolic regulatory mechanisms and new therapeutic strategies: American Diabetes Association Lilly Lecture, 2001.

C. Newgard, Christopher B Newgard, 2002, Diabetes.

Targeted Metabolomics Demonstrates Distinct and Overlapping Maternal Metabolites Associated With BMI, Glucose, and Insulin Sensitivity During Pregnancy Across Four Ancestry Groups

D. Scholtens, O. Ilkayeva, C. Newgard, 2017, Diabetes Care.

Metabolites and diabetes remission after weight loss

Nathan A. Bihlmeyer, B. Wolfe, O. Ilkayeva, 2021, Nutrition & Diabetes.

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.

P. MacDonald, M. Ferdaoussi, X. Dai, 2015, Cell reports.

Metabolic Networks and Metabolites Underlie Associations Between Maternal Glucose During Pregnancy and Newborn Size at Birth

William L. Lowe, Denise M. Scholtens, James R. Bain, 2016, Diabetes.

High heritability of metabolomic profiles in families burdened with premature cardiovascular disease

Geoffrey S Ginsburg, Elizabeth R Hauser, William E Kraus, 2009, Molecular systems biology.

Gut microbiome contributions to altered metabolism in a pig model of undernutrition

Michael J. Barratt, B. Henrissat, J. Gordon, 2021, Proceedings of the National Academy of Sciences.

Maternal Metabolites Associated with Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism.

D. Scholtens, O. Ilkayeva, C. Newgard, 2021, The Journal of clinical endocrinology and metabolism.

Overexpression of G11alpha and isoforms of phospholipase C in islet beta-cells reveals a lack of correlation between inositol phosphate accumulation and insulin secretion.

C. Newgard, R. Gasa, T. Wilkie, 1999, Diabetes.

Biochemical Mechanism of Lipid-induced Impairment of Glucose-stimulated Insulin Secretion and Reversal with a Malate Analogue*

H. Mulder, M. Jensen, C. Newgard, 2004, Journal of Biological Chemistry.

The Study of the Effects of Diet on Metabolism and Nutrition (STEDMAN) weight loss project: Rationale and design.

L. Svetkey, C. Newgard, C. Slentz, 2005, Contemporary clinical trials.

Analysis of the protein products encoded by variant glucokinase transcripts via expression in bacteria

C. Newgard, P. Iynedjian, A. Sestak, 1991, FEBS letters.

Plasma acylcarnitine profiling indicates increased fatty acid oxidation relative to tricarboxylic acid cycle capacity in young, healthy low birth weight men

A. Vaag, C. Newgard, R. Ribel‐Madsen, 2016, Physiological reports.

Maternal metabolites during pregnancy are associated with newborn outcomes and hyperinsulinaemia across ancestries

D. Scholtens, F. T. E. Group, O. Ilkayeva, 2018, Diabetologia.

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

Denise M. Scholtens, James R. Bain, Anna C. Reisetter, 2017, Diabetologia.

Pe ~ spectives in Diabetes Organizing Glucose Disposal Emerging Roles of the Glycogen Targeting Subunits of Protein Phosphatase-1

C. Newgard, M. Brady, R. O’Doherty, 2006 .

Perspectives in Diabetes Organizing Glucose Disposal Emerging Roles of the Glycogen Targeting Subunits of Protein Phosphatase-1

C. Newgard, A. Saltiel, M. Brady, 2000 .

Mutant IDH and non-mutant chondrosarcomas display distinct cellular metabolomes

B. Alman, J. Wunder, O. Ilkayeva, 2021, Cancer & metabolism.

Analysis of serum metabolic profiles in women with endometrial cancer and controls in a population-based case-control study.

Jolanta Lissowska, Montserrat Garcia-Closas, Marc J Gunter, 2012, The Journal of clinical endocrinology and metabolism.

musclegene transcription in denervated skeletal Regulation of glucose transporters GLUT-4 and

C. Gomez, R. Bassel-Duby, C. Newgard, 2015 .

SRC-2 Coactivator Deficiency Decreases Functional Reserve in Response to Pressure Overload of Mouse Heart

Xian Chen, M. Entman, B. O’Malley, 2012, PloS one.

Paradoxical activation of SREBP1c and de novo lipogenesis by hepatocyte-selective ACLY depletion in obese mice

Lawrence M. Lifshitz, Xianlin Han, R. Friedline, 2022, bioRxiv.

The promoter for the gene encoding the catalytic subunit of rat glucose-6-phosphatase contains two distinct glucose-responsive regions.

J. Haycock, C. Newgard, D. Scott, 2007, American journal of physiology. Endocrinology and metabolism.

Glucose-6-phosphatase Overexpression Lowers Glucose 6-Phosphate and Inhibits Glycogen Synthesis and Glycolysis in Hepatocytes without Affecting Glucokinase Translocation

C. Newgard, A. Lange, L. Agius, 1999, The Journal of Biological Chemistry.

Kruppel-like factor 15 is required for the cardiac adaptive response to fasting

O. Ilkayeva, C. Newgard, L. Fan, 2018, PloS one.

Peripheral blood metabolite profiles associated with new onset atrial fibrillation

C. Granger, C. Newgard, K. Pieper, 2019, American heart journal.

Validation of the association between a branched chain amino acid metabolite profile and extremes of coronary artery disease in patients referred for cardiac catheterization.

W. Kraus, C. Granger, E. Hauser, 2014, Atherosclerosis.

Comprehensive Metabolic Analysis for Understanding of Disease Mechanisms

O. Ilkayeva, C. Newgard, J. Bain, 2009 .

The coactivator SRC-1 is an essential coordinator of hepatic glucose production.

P. Saha, B. O’Malley, Jianming Xu, 2010, Cell metabolism.

Metabolic profiles predict adverse events after coronary artery bypass grafting.

W. Kraus, C. Granger, E. Hauser, 2012, The Journal of thoracic and cardiovascular surgery.

Loss of CHIP Expression Perturbs Glucose Homeostasis and Leads to Type II Diabetes through Defects in Microtubule Polymerization and Glucose Transporter Localization

C. Newgard, J. Schisler, Holly McDonough, 2016, bioRxiv.

Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism.

S. Hilsenbeck, A. Means, O. Ilkayeva, 2016, Molecular endocrinology.

Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse.

A. Means, C. Newgard, M. Muehlbauer, 2012, Molecular endocrinology.

Somatostatin-like immunoactivity and biological activity is present in Tetrahymena pyriformis, a ciliated protozoan.

J. Shiloach, D. Leroith, C. Newgard, 1982, Endocrinology.

Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.

H. Cohen, W. Kraus, E. Ravussin, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

expression in rat skeletal muscles Muscle contractile activity regulates Sirt3 protein

Matthew J. Rardin, Alexander S. Banks, C. Kahn, 2015 .

Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program

O. Ilkayeva, C. Newgard, M. Czech, 2023, Cell reports.

Mechanisms controlling pancreatic islet cell function in insulin secretion

C. Newgard, Jonathan E. Campbell, 2021, Nature Reviews Molecular Cell Biology.

phosphatase contains two distinct glucose-responsive regions

J. Haycock, C. Newgard, D. Scott, 2006 .

Organizing glucose disposal: emerging roles of the glycogen targeting subunits of protein phosphatase-1.

C. Newgard, A. Saltiel, M. Brady, 2000, Diabetes.

Cell lines derived from pancreatic islets

C. Newgard, H. Hohmeier, 2004, Molecular and Cellular Endocrinology.

Delayed apoptosis allows islet β-cells to implement an autophagic mechanism to promote cell survival

Brett S. Peterson, C. Newgard, S. Stephens, 2017, PloS one.

Correction: Genetic Networks of Liver Metabolism Revealed by Integration of Metabolic and Transcriptional Profiling

B. Yandell, C. Kendziorski, E. C. Neto, 2008, PLoS Genetics.

Improving human β-cell maturation in vitro

C. Newgard, J. An, H. Hohmeier, 2019, Nature Cell Biology.

Mixture model normalization for non-targeted gas chromatography/mass spectrometry metabolomics data

D. Scholtens, O. Ilkayeva, C. Newgard, 2017, BMC Bioinformatics.

Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions[S]

B. Stoll, D. Burrin, C. Newgard, 2016, Journal of Lipid Research.

Research resource: tissue- and pathway-specific metabolomic profiles of the steroid receptor coactivator (SRC) family.

S. Hilsenbeck, B. O’Malley, Jianming Xu, 2013, Molecular endocrinology.

Glucose-stimulated insulin secretion in cell lines

C. Newgard, L. Cassidy, 1994 .

OR07-1 Cord Blood Metabolomics: Association with Newborn Anthropometrics and C-Peptide across Ancestries

D. Scholtens, O. Ilkayeva, C. Newgard, 2019, Journal of the Endocrine Society.

The control strength of glucokinase in hepatocytes: A predictor of metabolic defects in maturity onset diabetes of the young, type 2

C. Newgard, L. Agius, S. Aiston, 2000 .

Human amylin proteotoxicity impairs protein biosynthesis, and alters major cellular signaling pathways in the heart, brain and liver of humanized diabetic rat model in vivo

C. Newgard, J. Schisler, J. Bain, 2016, Metabolomics.

Ghrelin concentrations in Prader–Willi syndrome (PWS) infants and children: changes during development

S. Grambow, L. Svetkey, C. Newgard, 2008, Clinical endocrinology.

Disrupted Maturation of the Microbiota and Metabolome among Extremely Preterm Infants with Postnatal Growth Failure

R. Goldberg, C. Newgard, J. Bain, 2019, Scientific Reports.

Peptide-mediated targeting of the islets of Langerhans.

Stephen Albert Johnston, C. Newgard, S. Johnston, 2005, Diabetes.

Prevotella copri -linked effects of a therapeutic food for malnutrition

Daniel M. Webber, Michael J. Barratt, A. Osterman, 2023 .

Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells

P. McNamara, C. Newgard, Danhong Lu, 2020, PloS one.

HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism

T. Kepler, R. McLendon, H. Liao, 2016, The Journal of Immunology.

Functional Genomics of the (cid:1) -Cell: Short-Chain 3-Hydroxyacyl-Coenzyme A Dehydrogenase Regulates Insulin Secretion Independent of K (cid:2) Currents

K. Kaestner, P. White, C. Newgard, 2007 .

Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis.

B. O’Malley, Jianming Xu, C. Newgard, 2014, Molecular endocrinology.

Maternal and Paternal Exercise Induce Distinct Metabolite Signatures in Offspring Tissues.

O. Ilkayeva, C. Newgard, L. Goodyear, 2022, Diabetes.

Metabolomic Profiling Reveals Distinct Patterns of Myocardial Substrate Use in Humans With Coronary Artery Disease or Left Ventricular Dysfunction During Surgical Ischemia/Reperfusion

D. Glower, J. Mathew, M. Podgoreanu, 2009, Circulation.

A VGF-derived peptide attenuates development of type 2 diabetes via enhancement of islet β-cell survival and function.

C. Newgard, J. Schisler, J. An, 2012, Cell metabolism.

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

S. Levy, R. Stein, K. Vickers, 2017, Cell metabolism.

Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

P. MacDonald, X. Dai, M. Jensen, 2017, Diabetes.

Physiological mechanisms of sustained fumagillin-induced weight loss.

T. Hughes, J. Gordon, O. Ilkayeva, 2018, JCI Insight.

Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance.

O. Ilkayeva, C. Newgard, J. Bain, 2008, Cell metabolism.

Race and sex differences in small-molecule metabolites and metabolic hormones in overweight and obese adults.

Bryan C. Batch, L. Svetkey, C. Newgard, 2013, Omics : a journal of integrative biology.

Prior Dietary Practices and Connections to a Human Gut Microbial Metacommunity Alter Responses to Diet Interventions.

A. Heath, J. Gordon, O. Ilkayeva, 2017, Cell host & microbe.

SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome.

Robert V Farese, M. Laakso, F. Alt, 2011, Molecular cell.

SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks.

Matthew J. Rardin, M. Jacobson, B. Gibson, 2013, Cell metabolism.

Temporal dynamics of liver mitochondrial protein acetylation and succinylation and metabolites due to high fat diet and/or excess glucose or fructose

Matthew J. Rardin, E. Verdin, O. Ilkayeva, 2018, PloS one.

Obesity and lipid stress inhibit carnitine acetyltransferase activity[S]

O. Ilkayeva, C. Newgard, D. Muoio, 2014, Journal of Lipid Research.

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

T. Hastie, A. Raja, S. Sealfon, 2020, Cell.

Overexpression of pre-pro-cholecystokinin stimulates beta-cell proliferation in mouse and human islets with retention of islet function.

Philipp W. Raess, A. Attie, C. Newgard, 2008, Molecular endocrinology.

Liver receptor homolog‐1 is a critical determinant of methyl‐pool metabolism

Jennifer L Mamrosh, J. Borén, D. Moore, 2016, Hepatology.

SIRT3 regulates fatty acid oxidation via reversible enzyme deacetylation

Robert V Farese, F. Alt, C. Kahn, 2009, Nature.

Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions[S]

B. Stoll, D. Burrin, C. Newgard, 2016, Journal of Lipid Research.

regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation.

E. Verdin, O. Ilkayeva, C. Newgard, 2016 .

Plasma amino acid levels are elevated in young, healthy low birth weight men exposed to short‐term high‐fat overfeeding

A. Vaag, C. Newgard, R. Ribel‐Madsen, 2016, Physiological reports.

Deletion of GαZ Protein Protects against Diet-induced Glucose Intolerance via Expansion of β-Cell Mass*

P. Casey, C. Newgard, J. B. Moss, 2012, The Journal of Biological Chemistry.

Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation

B. Alman, J. Wunder, C. Newgard, 2023, Cell reports.

Dietary Patterns among Asian Indians Living in the United States Have Distinct Metabolomic Profiles That Are Associated with Cardiometabolic Risk.

D. Scholtens, O. Ilkayeva, C. Newgard, 2018, The Journal of nutrition.

Adenylosuccinate Is an Insulin Secretagogue Derived from Glucose-Induced Purine Metabolism.

P. MacDonald, M. Ferdaoussi, X. Dai, 2015, Cell reports.

Research Resource: Roles for Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CaMKK2) in Systems Metabolism.

S. Hilsenbeck, A. Means, O. Ilkayeva, 2016, Molecular endocrinology.

Transcriptional activation of the Myc gene by glucose in β-cells requires a ChREBP-dependent 3-D chromatin interaction between the Myc and Pvt1 genes

Peng Wang, C. Newgard, Pili Zhang, 2023, Molecular metabolism.

Improving human β-cell maturation in vitro

C. Newgard, J. An, H. Hohmeier, 2019, Nature Cell Biology.

Annals of the New York Academy of Sciences Application of Combined Omics Platforms to Accelerate Biomedical Discovery in Diabesity

D. Accili, C. Burant, G. Ronnett, 2022 .

Circulating metabolic profile in idiopathic pulmonary fibrosis: data from the IPF-PRO Registry

C. Newgard, T. Leonard, A. Namen, 2024, Respiratory research.

Prevotella copri and microbiota members mediate the beneficial effects of a therapeutic food for malnutrition

A. Osterman, C. Lebrilla, C. Newgard, 2024, Nature microbiology.

Prevotella copri-related effects of a therapeutic food for malnutrition

A. Osterman, C. Lebrilla, C. Newgard, 2023, bioRxiv.

APOL1-mediated monovalent cation transport contributes to APOL1-mediated podocytopathy in kidney disease

C. Newgard, M. Muehlbauer, D. Muoio, 2024, The Journal of clinical investigation.

Metabolite signature of diabetes remission in individuals with obesity undergoing weight loss interventions

C. Newgard, L. Kwee, B. Laferrère, 2023, Obesity.

Metabolomic and genetic architecture of gestational diabetes subtypes.

C. Newgard, J. Bain, M. Muehlbauer, 2024, Diabetologia.