H. Hemker

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Heparins: A Shift of Paradigm

H. Hemker, R. al Dieri, S. Béguin, 2019, Front. Med..

The limits of simulation of the clotting system

H C Hemker, P. Hemker, H. Hemker, 2006, Journal of thrombosis and haemostasis : JTH.

Adsorption Kinetics of Protein Mixtures A Tentative Explanation of the Vroman Effect

H. Hemker, G. Willems, W. Hermens, 1987 .

Analysis and simulation of biochemical systems

Benno Hess, H. C. Hemker, B. Hess, 1972 .

Calibrated Automated Thrombin Generation Measurement in Clotting Plasma

H. Coenraad Hemker, Thomas Lecompte, H. Hemker, 2003, Pathophysiology of Haemostasis and Thrombosis.

Peptide Bond Cleavages and Loss of Functional Activity during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C (*)

H. Hemker, G. Nicolaes, J. Rosing, 1995, The Journal of Biological Chemistry.

A Prothrombinase-based Assay for Detection of Resistance to Activated Protein C

H. Hemker, G. Nicolaes, R. van Oerle, 1996, Thrombosis and Haemostasis.

Low molecular weight activated protein C inhibitors as a potential treatment for hemophilic disorders.

H. Hemker, S. Béguin, P. Giesen, 2006, Journal of medicinal chemistry.

Thrombin generation, a function test of the haemostaticthrombotic system

H. Hemker, R. al Dieri, S. Béguin, 2006, Thrombosis and Haemostasis.

Phenotyping the Clotting System

H. Hemker, S. Béguin, P. Giesen, 2002, Thrombosis and Haemostasis.

Measurement of Thrombin Generation in Whole Blood - The Effect of Heparin and Aspirin

H. Hemker, S. Béguin, C. Hemker, 1994, Thrombosis and Haemostasis.

A rational approach to heparins.

H. Hemker, S. Béguin, 1992, Nouvelle revue francaise d'hematologie.

On the Relationship Between Molecular Mass and Anticoagulant Activity in a Low Molecular Weight Heparin (Enoxaparin)

E. Pacaud, H. Hemker, S. Béguin, 1992, Thrombosis and Haemostasis.

The Mode of Action of CY216 and CY222 in Plasma

H. Hemker, S. Béguin, J. Lormeau, 1992, Thrombosis and Haemostasis.

Determination of the levels of unfractionated and low-molecular-weight heparins in plasma: their effect on thrombin-mediated feedback reactions in vivo. Preliminary results after subcutaneous injection.

H. Hemker, S. Béguin, S. Wielders, 1991, Haemostasis.

Low Molecular Weight Heparin-Catalyzed Inactivation of Factor Xa and Thrombin by Antithrombin lll-Effect of Platelet Factor 4

H. Hemker, P. Schoen, Theo L indhout, 2022 .

The Mode of Action of CY 216 and CY 222 in Plasma

H. Hemker, J. C. L. rmeau, 2022 .

Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor

T. Barbui, H. Hemker, C. Maassen, 1990, The Lancet.

ORAL TREATMENT OF HÆMOPHILIA A BY GASTROINTESTINAL ABSORPTION OF FACTOR VIII ENTRAPPED IN LIPOSOMES

H. Hemker, W. Hermens, R. Zwaal, 1980, The Lancet.

Sex hormone-binding globulin and thrombin generation in women using hormonal contraception

H. Hemker, M. Alhenc-Gelas, J. Hugon-Rodin, 2017, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Can global assays make anticoagulation safer and more effective?

H. Hemker, 2016, Clinical advances in hematology & oncology : H&O.

Thrombin Generating Capacity and Phenotypic Association in ABO Blood Groups

H. Hemker, R. al Dieri, D. Huskens, 2015, PloS one.

The effect of fibrin(ogen) on thrombin generation and decay

H. Hemker, R. Wagenvoord, R. Kremers, 2014, Thrombosis and Haemostasis.

A new regulatory function of activated factor V: inhibition of the activation by tissue factor/factor VII(a) of factor X

H. Hemker, R. al Dieri, R. Wagenvoord, 2013, Journal of thrombosis and haemostasis : JTH.

Thrombin generation: what have we learned?

H. Hemker, R. al Dieri, B. de Laat, 2012, Blood reviews.

No effect of ethanol intake on thrombin generation parameters.

H. Hemker, R. al Dieri, M. Pieters, 2012, Thrombosis research.

Fluorogenic Peptide‐Based Substrates for Monitoring Thrombin Activity

H. Hemker, F. Rutjes, R. Wagenvoord, 2012, ChemMedChem.

Thrombin generation is extremely sensitive to preheating conditions

H. Hemker, E. De Smedt, 2011, Journal of thrombosis and haemostasis : JTH.

Thrombin generation assay using factor IXa as a trigger to quantify accurately factor VIII levels in haemophilia A

H. Hemker, R. van Oerle, Y. Dargaud, 2011, Journal of thrombosis and haemostasis : JTH.

Thrombin generation and plasma dilution.

H. Hemker, W. Chandler, M. Roshal, 2010, American journal of clinical pathology.

Evaluation of the procoagulant activity in the plasma of cancer patients using a thrombin generation assay.

H. Hemker, F. Corazza, D. Noubouossie, 2010, Thrombosis research.

High subretinal fluid procoagulant activity in rhegmatogenous retinal detachment.

A. Liem, H. Hemker, A. Kijlstra, 2010, Investigative ophthalmology & visual science.

Monitoring platelet dependent thrombin generation in mice.

H. Hemker, H. ten Cate, Y. Dargaud, 2010, Thrombosis research.

Thrombin generation in mesalazine refractory ulcerative colitis and the influence of low molecular weight heparin

H. Hemker, R. Wagenvoord, G. Dijkstra, 2007, Journal of Thrombosis and Thrombolysis.

Phenotyping the haemostatic system by thrombography--potential for the estimation of thrombotic risk.

H. Hemker, T. Lecompte, V. Regnault, 2004, Thrombosis research.

Initiating and potentiating role of platelets in tissue factor‐induced thrombin generation in the presence of plasma: subject‐dependent variation in thrombogram characteristics

H. Hemker, J. Heemskerk, P. Giesen, 2004, Journal of thrombosis and haemostasis : JTH.

Fibrin polymerization is crucial for thrombin generation in platelet‐rich plasma in a VWF–GPIb‐dependent process, defective in Bernard–Soulier syndrome

H. Hemker, R. al Dieri, S. Béguin, 2004, Journal of thrombosis and haemostasis : JTH.

Thrombin generation assays: accruing clinical relevance

H. Hemker, R. al Dieri, S. Béguin, 2004, Current opinion in hematology.

The Effect of Trace Amounts of Tissue Factor on Thrombin Generation in Platelet Rich Plasma, its Inhibition by Heparin

H. Hemker, S. Béguin, T. Lindhout, 1989, Thrombosis and Haemostasis.

Continuous Registration of Thrombin Generation in Plasma, Its Use for the Determination of the Thrombin Potential

H. Hemker, S. Béguin, S. Wielders, 1993, Thrombosis and Haemostasis.

Thrombin generation: An essential step in haemostasis and thrombosis

H. Hemker, 1994 .

The Influence of Fibrinogen and Fibrin on Thrombin Generation - Evidence for Feedback Activation of the Clotting System by Clot Bound Thrombin

H. Hemker, S. Béguin, R. Kumar, 1994, Thrombosis and Haemostasis.

Inhibition of platelet-mediated, tissue factor-induced thrombin generation by the mouse/human chimeric 7E3 antibody. Potential implications for the effect of c7E3 Fab treatment on acute thrombosis and "clinical restenosis".

H. Hemker, S. Béguin, B. Coller, 1996, The Journal of clinical investigation.

Oral contraceptives and venous thrombosis: different sensitivities to activated protein C in women using second‐ and third‐generation oral contraceptives

H. Hemker, G. Nicolaes, R. van Oerle, 1997, British journal of haematology.

The Routine Determination of the Endogenous Thrombin Potential, First Results in Different Forms of Hyper- and Hypocoagulability

V. Kakkar, H. Hemker, S. Béguin, 1997, Thrombosis and Haemostasis.

Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor.

H. Hemker, S. Béguin, R. Kumar, 1999, Blood.

The Effect of DDAVP Infusion on Thrombin Generation in Platelet-rich Plasma of von Willebrand Type 1 and in Mild Haemophilia A Patients

H. Hemker, S. Béguin, K. Hamulýak, 2000, Thrombosis and Haemostasis.

The Role of Factor XI in Thrombin Generation Induced by Low Concentrations of Tissue Factor

H. Hemker, S. Béguin, A. Zivelin, 2001, Thrombosis and Haemostasis.

Will One Size of Anticoagulant Dosage Fit All?

H. Hemker, R. al Dieri, B. de Laat, 2013 .

The Anticoagulant and Nonanticoagulant Properties of Heparin

C. Reutelingsperger, H. Hemker, G. Nicolaes, 2020, Thrombosis and Haemostasis.

Purification and Properties of Staphylocoagulase

H. Hemker, A. Muller, B. M. Bas, 1975, Thrombosis and Haemostasis.

Clustering of lipid-bound annexin V may explain its anticoagulant effect.

H. Hemker, G. Willems, W. Hermens, 1992, The Journal of biological chemistry.

Annexin V inhibits the procoagulant activity of matrices of TNF-stimulated endothelium under blood flow conditions.

J. Sixma, C. Reutelingsperger, P. D. de Groot, 1994, Arteriosclerosis and thrombosis : a journal of vascular biology.

During coagulation, thrombin generation shifts from chemical to diffusional control

P. Hemker, H. Hemker, H. C. HEMKER, 2005, Journal of thrombosis and haemostasis : JTH.

The application of thrombin generation in real life clinical situations.

H. Hemker, 2015, Thrombosis research.

Mathematical and biological models of blood coagulation. A rebuttal

P. Hemker, H. Hemker, E. De Smedt, 2006, Journal of thrombosis and haemostasis : JTH.

Human Blood Coagulation

H. Hemker, J. Veltkamp, E. Loeliger, 1969, Boerhaave Series for Postgraduate Medical Education.

On the clot-promoting activity of human platelets in a one-stage prothrombinase assay.

H. Hemker, P. Comfurius, E. Bevers, 1982, Haemostasis.

Prothrombin conversion under flow conditions by prothrombinase assembled on adherent platelets

H. Hemker, J. Heemskerk, J. Briedé, 1997, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

The love of the artist for his model of thrombin generation

H. Hemker, S. Béguin, 2004, Journal of thrombosis and haemostasis : JTH.

Thrombin Generation and Atherothrombosis: What Does the Evidence Indicate?

H. Hemker, H. ten Cate, 2016, Journal of the American Heart Association.

Conjectures and Refutations on the Mode of Action of Heparins

H. Hemker, R. al Dieri, S. Béguin, 1999, Pathophysiology of Haemostasis and Thrombosis.

13 Thrombosis and Thrombin

H. Hemker, S. Béguin, 2007 .

The ionic contrast medium ioxaglate interferes with thrombin‐mediated feedback activation of factor V, factor VIII and platelets

H. Hemker, R. al Dieri, S. Béguin, 2003, Journal of thrombosis and haemostasis : JTH.

Mode of action of unfractionated and low molecular weight heparins on the generation of thrombin in plasma.

H. Hemker, S. Béguin, 1990, Haemostasis.

The mechanisms of thrombin formation

P. Devilee, H. Hemker, S. Béguin, 1989 .

The generation of thrombin in whole plasma. Biochemical possibilities and physiological realities.

H. Hemker, S. Béguin, 1985, Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie.

Inhibition of factor XIa by antithrombin III.

H. Hemker, G. Tans, H. Soons, 1987, Biochemistry.

The effect of platelets in the activation of human blood coagulation factor IX by factor XIa.

H. Hemker, G. Tans, H. Soons, 1986, Blood.

The effect of platelets in the activation of human blood coagulation factor IX by factor XIa

H. Hemker, G. Tans, H. Soons, 1986 .

factor VIII and factor V in thromboplastin-activated plasma In situ-generated thrombin is the only enzyme that effectively activates

H. Hemker, J. Pieters, T. Lindhout, 2011 .

In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma

H. Hemker, J. Pieters, T. Lindhout, 1989 .

Kinetics of thrombin-induced release and activation of platelet factor V.

D. Baruch, H. Hemker, T. Lindhout, 1986, European journal of biochemistry.

Assembly of the Intrinsic Factor X Activating Complex – Interactions between Factor IXa, Factor VIIIa and Phospholipid

H. Hemker, J. Rosing, J. Govers-Riemslag, 1985, Thrombosis and Haemostasis.

Activation of Bovine Factor IX By Bovine Factor XIa . Active Site Titration Of Factor IXa and Development of A spectro-Photometric assay for Factor IX

H. Hemker, J. Rosing, G. Tans, 1981 .

Pharmacokinetics and Pharmacodynamics of a Low Molecular Weight Heparin (Enoxaparin) after Subcutaneous Injection, Comparison with Unfractionated Heparin – A Three Way Cross Over Study in Human Volunteers

H. Hemker, S. Béguin, H. Caplain, 1994, Thrombosis and Haemostasis.

The Action of a Synthetic Pentasaccharide on Thrombin Generation in Whole Plasma

H. Hemker, S. Béguin, J. Choay, 1989, Thrombosis and Haemostasis.

Factor IXa Inhibition Contributes to the Heparin Effect

H. Hemker, S. Béguin, F. Dol, 1991, Thrombosis and Haemostasis.

Formation of Prothrombin Converting Activity

P. Hemker, H. Hemker, M. Esnouf, 1967, Nature.

Hypercoagulability resulting from opposite effects of lupus anticoagulants is associated strongly with thrombotic risk.

H. Hemker, P. Lacolley, T. Lecompte, 2007, Haematologica.

Kinetic aspects of the interaction of blood-clotting enzymes. II. The relation between clotting time and plasma concentration in prothrombin-time estimations.

H. Hemker, R. Altman, E. Loeliger, 1967, Thrombosis et diathesis haemorrhagica.

Low molecular weight heparin inhibits plasma thrombin generation via direct targeting of factor IXa: a rebuttal

H. Hemker, S. Béguin, 2013, Journal of thrombosis and haemostasis : JTH.

Inhibition of Prothrombinase by Antithrombin-Heparin at a Macroscopic Surface

H. Hemker, G. Willems, T. Lindhout, 1995, Thrombosis and Haemostasis.

Can the haemorrhagic component of heparin be identified? Or an attempt at clean thinking on a dirty drug.

V. Kakkar, H. Hemker, S. Béguin, 1996, Haemostasis.

The thrombin potential a Parameter to Assess the effect of antithrombotic drugs on thrombin generation

H. Hemker, S. Béguin, S. Wielders, 1990 .

Thrombin generation in low plasma volumes

H. Hemker, H. Kelchtermans, S. Bloemen, 2018, Thrombosis Journal.

The initiation phase – A review of old (clotting-) times

H. Hemker, C. Hemker, 2007, Thrombosis and Haemostasis.

The Effect of Fibrin Clots and Clot-Bound Thrombin on the Development of Platelet Procoagulant Activity

H. Hemker, S. Béguin, R. Kumar, 1995, Thrombosis and Haemostasis.

The mode of action of heparins in vitro and in vivo.

H. Hemker, S. Béguin, 1992, Advances in experimental medicine and biology.

Reaction Sequence of Blood Coagulation

H. Hemker, M. Kahn, 1967, Nature.

Effect of activated protein C on thrombin generation and on the thrombin potential in plasma of normal and APC‐resistant individuals

H. Hemker, G. Nicolaes, J. Rosing, 1997, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

The Consumption of Antithrombin III During Coagulation, Its Consequences for the Calculation of Prothrombinase Activity and the Standardisation of Heparin Activity

H. Hemker, S. Béguin, H. Kessels, 1992, Thrombosis and Haemostasis.

Evaluation of a coagulation assay determining the activity state of factor VII in plasma.

H. Hemker, M. V. van Dam-Mieras, W. A. van Deijk, 1983, Haemostasis.

Global/integral assays in hemostasis diagnostics: promises, successes, problems and prospects

H. Hemker, M. Panteleev, 2015, Thrombosis Journal.

Thrombin Generation in a Reconstituted System: A Comment

H. Hemker, 2002, Thrombosis and Haemostasis.

Prothrombin conversion is accelerated in the antiphospholipid syndrome and insensitive to thrombomodulin.

P. D. de Groot, H. Hemker, S. Zuily, 2018, Blood advances.

The Effect of Subcutaneous Injection of Unfractionated and Low Molecular Weight Heparin on Thrombin Generation in Platelet Rich Plasma - A Study in Human Volunteers

H. Hemker, S. Béguin, R. Knebel, 1994, Thrombosis and Haemostasis.

Activation of human prothrombin by stoichiometric levels of staphylocoagulase.

H. Hemker, K. Mertens, H. Hendrix, 1983, The Journal of biological chemistry.

Feedback Mechanisms in Blood Coagulation and Their Inhibition by Heparins

H. Hemker, 1991 .

Prothrombin Activation by Prothrombinase in a Tubular Flow Reactor (*)

H. Hemker, G. Willems, T. Lindhout, 1995, The Journal of Biological Chemistry.

von Willebrand factor stimulates thrombin‐induced exposure of procoagulant phospholipids on the surface of fibrin‐adherent platelets

D. Baruch, H. Hemker, J. Heemskerk, 2003, Journal of thrombosis and haemostasis : JTH.

Endogenous thrombin potential

H. Hemker, S. Béguin, 1999 .

Treatment with a GPIIb/IIIa antagonist inhibits thrombin generation in platelet rich plasma from patients.

H. Hemker, S. Béguin, C. de Zwaan, 1998, Thrombosis and haemostasis.

Fibrin-dependent platelet procoagulant activity requires GPIb receptors and von Willebrand factor

H. Hemker, S. Béguin, B. Coller, 1999 .

Antithrombin III-dependent anti-prothrombinase activity of heparin and heparin fragments.

H. Hemker, G. Willems, P. Schoen, 1989, The Journal of biological chemistry.

Comment on the use of computational models to study the effect of apixaban and rivaroxaban on thrombin generation.

H. Hemker, R. Wagenvoord, R. Kremers, 2015, Thrombosis and haemostasis.

A Chromogenic Test to Determine the Procoagulant Phospholipids in Platelet-rich Plasma and Whole Blood

H. Hemker, R. Wagenvoord, H. Hendrix, 1994, Thrombosis and Haemostasis.

Calibrated automated thrombinography (CAT).

H. Hemker, 2005, Thrombosis research.

The Relative Importance of the Factors II, VII, IX and X for the Prothrombinase Activity in Plasma of Orally Anticoagulated Patients

H. Hemker, S. Béguin, M. Xi, 1989, Thrombosis and Haemostasis.

The Elevated Risk for Venous Thrombosis in Persons with Hyperhomocysteinemia Is not Reflected by the Endogenous Thrombin Potential

M. den Heijer, H. Hemker, S. Béguin, 1999, Thrombosis and Haemostasis.

Prevention of the influence of fibrin and alpha2-macroglobulin in the continuous measurement of the thrombin potential: implications for an endpoint determination of the optical density.

H. Hemker, S. Béguin, D. Rijkers, 1998, Thrombosis research.

Thrombin-induced Hyperactivity of Platelets of Young Stroke Patients

J. Lodder, H. Hemker, E. V. van Pampus, 2002, Thrombosis and Haemostasis.

The Ca2+-mobilizing potency of alpha-thrombin and thrombin-receptor-activating peptide on human platelets -- concentration and time effects of thrombin-induced Ca2+ signaling.

H. Hemker, J. Rosing, J. Heemskerk, 1997, European journal of biochemistry.

The Inhibition of Platelet Prothrornbinase Activifv bv Prostacyclin

H. Hemker, P. Comfurius, E. Bevers, 2007 .

The inhibition of platelet prothrombinase activity by prostacyclin.

H. Hemker, P. Comfurius, E. Bevers, 1984, Haemostasis.

Lipid phase transitions and procoagulant activity.

H. Hemker, P. Comfurius, G. Tans, 1979, European journal of biochemistry.

Contribution of the Platelet Factor V Content to Platelet Factor 3 Activity

H. Hemker, E. Bevers, R. Zwaal, 1980, British journal of haematology.

Interaction of coagulation factors

H. Hemker, 1975 .

Elements from in vitro studies that help understand the action of heparins.

H. Hemker, S. Béguin, A. Bendetowicz, 1991, Thrombosis research. Supplement.

Molecular Biology and Pathophysiology of APC Resistance : Current Insights and Clinical lmplications

H. Hemker, J. Rosing, G. Tans, 2022 .

A convenient synthesis of amino acid p-nitroanilides; synthons in the synthesis of protease substrates

H. Hemker, D. Rijkers, G. I. Tesser, 1995 .

An ionic contrast agent inhibits platelet-dependent thrombin generation and boosts the effect of abciximab.

H. Hemker, R. al Dieri, S. Béguin, 2001, Thrombosis and haemostasis.

Factor XI–Dependent Reciprocal Thrombin Generation Consolidates Blood Coagulation when Tissue Factor Is Not Available

H. Hemker, S. Béguin, T. Lindhout, 2004, Arteriosclerosis, thrombosis, and vascular biology.

Low molecular weight heparin-catalyzed inactivation of factor Xa and thrombin by antithrombin III--effect of platelet factor 4.

H. Hemker, P. Schoen, T. Lindhout, 1991, Thrombosis and haemostasis.

The technique of measuring thrombin generation with fluorogenic substrates: 1. Necessity of adequate calibration

H. Hemker, R. al Dieri, H. ten Cate, 2008, Thrombosis and Haemostasis.

Inhibition of blood coagulation factors by serine esterase inhibitors

H. Hemker, J. de Lange, J. D. De Lange, 1972, FEBS letters.

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

P. Hemker, H. Hemker, 1968, Thrombosis and Haemostasis.

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

H. Hemker, J. Veltkamp, E. Loeliger, 1968, Thrombosis and Haemostasis.

Control of long-term anticoagulant treatment.

H. Hemker, E. Loeliger, 1970, Lancet.

Quantitation of circulating fibrinogen breakdown products in intravascular clotting.

H. Hemker, A. Hensen, E. Loeliger, 1966, Thrombosis et diathesis haemorrhagica. Supplementum.

Nature of Prothrombin Biosynthesis : Preprothrombinæmia in Vitamin K-deficiency

H. Hemker, J. Veltkamp, A. Hensen, 1963, Nature.

Treatment of haemophilia B with purified Factor IX (PPSB).

H. Hemker, P. Bruning, J. Veltkamp, 1967, Folia medica Neerlandica.

The Biological Disappearance Rate of Prothrombin, Factors VII, IX and X from Plasma in Hypothyroidism, Hyperthyroidism, and During Fever

H. Hemker, E. Loeliger, M. Mattern, 1963, Thrombosis and Haemostasis.

Purification and characterization of a novel protein from bovine aorta that inhibits coagulation. Inhibition of the phospholipid-dependent factor-Xa-catalyzed prothrombin activation, through a high-affinity binding of the anticoagulant to the phospholipids.

H. Hemker, J. Kop, G. Hornstra, 1988, European journal of biochemistry.

Isolation and partial purification of a novel anticoagulant from arteries of human umbilical cord.

H. Hemker, G. Hornstra, C. Reutelingsperger, 1985, European journal of biochemistry.

A reduction of prothrombin conversion by cardiac surgery with cardiopulmonary bypass shifts the haemostatic balance towards bleeding

J. Maessen, H. Hemker, R. al Dieri, 2016, Thrombosis and Haemostasis.

The determination of prothrombin using synthetic chromogenic substrates; choice of a suitable activator.

H. Hemker, B. Kirchhof, C. Vermeer, 1978, Thrombosis research.

The influence of cadmium ions on the adsorption of prothrombin onto A1(OH)3 as a means to purify prothrombin.

P. Devilee, H. Hemker, B. M. Bas, 1975, Biochimica et biophysica acta.

Activation of a pro-enzyme by a stoichiometric reaction with another protein. The reaction between prothrombin and staphylocoagulase.

H. Hemker, A. Muller, B. M. Bas, 1975, Biochimica et biophysica acta.

A Convenient Synthesis of Amino Acid p-Nitroanilides; Synthons in the Synthesis of Protease Substrates.

H. Hemker, D. Rijkers, G. I. Tesser, 1996 .

Quantitation of enzyme release from infarcted heart muscle.

H. Hemker, W. Hermens, L. Hollaar, 1971, British heart journal.

Quantitation of infarct size in man by means of plasma enzyme levels.

H. Hemker, W. Hermens, L. Hollaar, 1975, British heart journal.

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

H. Hemker, H. ten Cate, R. Wagenvoord, 2017, PloS one.

ELLIPSOMETRIC STUDY OF PROTEIN FILM ON CHROMIUM

H. Hemker, W. Hermens, P. Cuypers, 1977 .

Factor Xa Cleavage of Tissue Factor Pathway Inhibitor Is Associated with Loss of Anticoagulant Activity

H. Hemker, G. Willems, C. Hemker, 1998, Thrombosis and Haemostasis.

Activation of Factor IX by Factor XIa - A Spectrophotometric Assay for Factor IX in Human Plasma

H. Hemker, J. Rosing, G. Tans, 1982, Thrombosis and Haemostasis.

The Calibrated Automated Thrombogram (CAT): a universal routine test for hyper- and hypocoagulability

S. Béguin, H. Hemker, S. Béguin, 2002, Pathophysiology of Haemostasis and Thrombosis.

Low paediatric thrombin generation is caused by an attenuation of prothrombin conversion

H. Hemker, P. Monagle, R. Wagenvoord, 2016, Thrombosis and Haemostasis.

Characterization of an autosomal dominant bleeding disorder caused by a thrombomodulin mutation.

H. Hemker, J. Scoazec, C. Négrier, 2015, Blood.

The Activity of Unfractionated Heparin and Low Molecular Weight Heparins in Rabbit Plasma – The Need for Using Absolute Anti-factor Xa and Antithrombin Activities

H. Hemker, S. Béguin, B. Boneu, 1997, Thrombosis and Haemostasis.

Draculin, the anticoagulant factor in vampire bat saliva, is a tight-binding, noncompetitive inhibitor of activated factor X.

H. Hemker, S. Béguin, R. Apitz-Castro, 1999, Biochimica et biophysica acta.

Continuous Flow and the Prothrombinase-Catalyzed Activation of Prothrombin

H. Hemker, G. Willems, P. Schoen, 1990, Thrombosis and Haemostasis.

Oral administration of Factor Vlll in lipid vesicles

H. Hemker, R. Zwaal, 1982 .

Activation of human factor V by meizothrombin.

H. Hemker, G. Nicolaes, A. V. van Zonneveld, 1994, The Journal of biological chemistry.

Human factor Va1 and factor Va2: properties in the procoagulant and anticoagulant pathways.

H. Hemker, G. Nicolaes, J. Rosing, 1997, Biochemistry.

Characterization of two forms of human factor Va with different cofactor activities.

H. Hemker, J. Rosing, G. Tans, 1993, The Journal of biological chemistry.

Factor Xa induces cytokine production and expression of adhesion molecules by human umbilical vein endothelial cells.

H. Hemker, W. Buurman, R. Wagenvoord, 1998, Journal of immunology.

Studies on blood coagulation factor V : II preparation and properties of an artificial factor V reagent by adsorption with Ba-stearat

H. Hemker, M. Kahn, 1970 .

Randomized, placebo‐controlled trial of low molecular weight heparin in active ulcerative colitis

E. Schoon, H. Hemker, A. De Jong, 2003, Inflammatory bowel diseases.

Plasma Fractions for the Treatment of Hemophilia Anticoagul ant Therapy : Stand ardization of Tests

H. Hemker, E. Loeliger, A. Pavlovsky, 2007 .

Laboratory monitoring of low‐molecular‐weight heparin therapy—part II

H. Hemker, R. al Dieri, S. Béguin, 2005, Journal of thrombosis and haemostasis : JTH.

Handbook of synthetic substrates : for the coagulation and fibrinolytic system

H. Hemker, M. V. Dam-Mieras, 1983 .

The effect of factor Va on lipid dynamics in mixed phospholipid vesicles as detected by steady-state and time-resolved fluorescence depolarization of diphenylhexatriene.

H. Hemker, A. Visser, T. Lindhout, 1987, European journal of biochemistry.

Heterogeneous biocatalysis in the generation of thrombin

H. Hemker, R. Zwaal, 1982 .

Temperature dependent transitions in several phospholipids measured by ellipsometry

H. Hemker, J. Kop, W. Hermens, 1980 .

The Role of Surfaces in the Mechanism of Blood Coagulation

H. Hemker, G. Tans, 1979 .

The effect of gamma-carboxyglutamate residues on the enzymatic properties of the activated blood clotting factor X. I. Activity towards synthetic substrates.

H. Hemker, B. Kop-Klaassen, M. Lindhout, 1978, Biochimica et biophysica acta.

A new method for the preparation of artificial factor II reagents from normal human and bovine plasma.

H. Hemker, C. Vermeer, B. Soute, 1977, Thrombosis research.

Handbook of hemophilia

H. Hemker, K. Brinkhous, 1975 .

Inhibition of thrombin-catalyzed reactions in blood coagulation and platelet activation by heparin fractions in the absence of antithrombin III.

D. Baruch, H. Hemker, R. Wagenvoord, 1986, Haemostasis.

Effect of heparin and low molecular weight heparins on thrombin-induced blood platelet activation in the absence of antithrombin III.

D. Baruch, H. Hemker, T. Lindhout, 1985, Thrombosis research.

Measurement of macrophage cellular procoagulant activity.

H. Hemker, M. V. van Dam-Mieras, A. Muller, 1985, Haemostasis.

Clotting factors secreted by monocytes and macrophages: analytical considerations.

H. Hemker, M. V. van Dam-Mieras, W. A. van Deijk, 1985, Thrombosis research.

Reevaluation of some properties of fibrinogen, purified from cord blood of normal newborns.

P. Devilee, H. Hemker, K. Hamulýak, 1983, Thrombosis research.

4 Anticoagulant Mechanism of Action of Low Molecular Weight Heparins

H. Hemker, T. Lindhout, 2007 .

A standard for low molecular weight heparin?

H. Hemker, 1989, Haemostasis.

[The Choay domain -- the structure responsible for the anticoagulant action of heparins].

H. Hemker, R. al Dieri, S. Béguin, 2003, Bulletin de l'Academie nationale de medecine.

Pharmacokinetic and Pharmacodynamic Characterization of a Medium-Molecular-Weight Heparin in Comparison with UFH and LMWH

H. Hemker, S. Alban, D. Welzel, 2002, Seminars in thrombosis and hemostasis.

Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a bleeding disorder.

H. Hemker, J. Rosing, H. Weiss, 1985, Blood.

The effect of phospholipids, calcium ions and protein S on rate constants of human factor Va inactivation by activated human protein C.

J. Griffin, H. Hemker, J. Rosing, 1992, European journal of biochemistry.

Molecular biology and pathophysiology of APC resistance: current insights and clinical implications.

H. Hemker, J. Rosing, G. Tans, 1998, Seminars in thrombosis and hemostasis.

Meizothrombin formation during factor Xa-catalyzed prothrombin activation. Formation in a purified system and in plasma.

H. Hemker, J. Rosing, G. Tans, 1991, The Journal of biological chemistry.

A double-blind trial of long-term anticoagulant treatment after myocardial infarction.

H. Hemker, F. Kroes, A. Hensen, 1967, Acta medica Scandinavica.

Second International Symposium Recent Pharmacological and Clinical Data

H. Hemker, S. Wielders, 2007 .

Free factor Xa is on the main pathway of thrombin generation in clotting plasma.

H. Hemker, S. Béguin, J. Choay, 1989, Biochimica et biophysica acta.

Comparison between the effect of pentosan polysulphate heparin and antithrombin III injections in antithrombin III deficient patients.

H. Hemker, S. Béguin, J. Goudemand, 1985, Thrombosis research.

Interaction of prothrombin with factor Va-phospholipid complexes.

H. Hemker, T. Lindhout, P. van de Waart, 1984, Biochemistry.

Interaction of bovine blood clotting factor Va and its subunits with phospholipid vesicles.

H. Hemker, H. Bruls, T. Lindhout, 1983, Biochemistry.

Blood cell membranes and haemostasis.

H. Hemker, R. Zwaal, 1982, Haemostasis.

Randomized, placebo-controlled trial of low molecular weight heparin in active ulcerative colitis.

E. Schoon, H. Hemker, A. De Jong, 2007, Inflammatory bowel diseases.

Low Molecular Weight Heparin Treatment in Steroid Refractory Ulcerative Colitis: Clinical Outcome and Influence on Mucosal Capillary Thrombi

E. Schoon, H. Hemker, J. Jansen, 2001, Scandinavian journal of gastroenterology. Supplement.

Half-life time and control frequency of vitamin K-dependent Coagulation factors. Theoretical considerations on the place of factor VII in the control of oral anticoagulation therapy.

H. Hemker, M. V. van Dam-Mieras, 1983, Haemostasis.

Regulation of Platelet Factor Va-dependent Thrombin Generation by Activated Protein C at the Surface of Collagen-adherent Platelets*

H. Hemker, G. Willems, J. Briedé, 2001, The Journal of Biological Chemistry.

Functional properties of factor Va subunits after proteolytic alterations by activated protein C.

H. Hemker, H. Bruls, T. Lindhout, 1984, Biochimica et biophysica acta.

Inhibition of Tissue Factor-Factor VIIa-catalyzed Factor X Activation by Factor Xa-Tissue Factor Pathway Inhibitor

H. Hemker, G. Willems, T. Lindhout, 1999, The Journal of Biological Chemistry.

Importance of factor-IX-dependent prothrombinase formation--the Josso pathway--in clotting plasma.

H. Hemker, S. Béguin, M. Xi, 1989, Haemostasis.

Activation of factor IX by factor XIa

H. Hemker, J. Rosing, G. Tans, 1982 .

Thrombosis and Haemostasis formerly Thrombosis et Diathesis Haemorrhagica founded

H. Hemker, J. Rosing, G. Tans, 2022 .

Kinetic aspects of the interaction of blood clotting enzymes

H. Hemker, A. Muller, H. C. Hrlrrcn, 2007 .

The interaction between prothrombin and staphylocoagulase

H. Hemker, A. Muller, B. M. Bas, 1975 .

Localization of the Inhibitory Site(s) of Pentosan Polysulphate in Blood Coagulation

C. Soria, H. Hemker, R. Wagenvoord, 1988, Thrombosis and Haemostasis.

The Role of Phospholipids and Factor Va in the Mechanism of Prothrombin Activation

H. Hemker, J. Rosing, J. Govers-Riemslag, 1979 .

Contact Activation in the Extrinsic Blood Clotting System

H. Hemker, R. Altman, 1967, Thrombosis and Haemostasis.

Effect of a thrombolytic agent (urokinase) on necrosis after acute myocardial infarction.

H. Hemker, W. Hermens, L. Hollaar, 1975, Recent advances in studies on cardiac structure and metabolism.

Contribution of Platelet-derived Factor Va to Thrombin Generation on Immobilized Collagen- and Fibrinogen-adherent Platelets

H. Hemker, J. Heemskerk, J. Briedé, 2001, Thrombosis and Haemostasis.

The activity state of factor VII in plasma: two pathways for the cold promoted activation of factor VII

P. Devilee, H. Hemker, A. Muller, 1986, British journal of haematology.

Heterogeneity in microparticle formation and exposure of anionic phospholipids at the plasma membrane of single adherent platelets.

H. Hemker, J. Heemskerk, J. Briedé, 1999, Biochimica et biophysica acta.

The influence of glycerol on the Ca flux in the isolated perfused rat heart

H. Hemker, H. Frank, 1976, Basic Research in Cardiology.

Anticoagulant mechanism of action of low molecular weight heparins

H. Hemker, T. Lindhout, 1992 .

Expression of biological activity of draculin, the anticoagulant factor from vampire bat saliva, is strictly dependent on the appropriate glycosylation of the native molecule.

H. Hemker, S. Béguin, R. Apitz-Castro, 1998, Biochimica et biophysica acta.

Purification and Partial Characterization of Draculin, the Anticoagulant Factor Present in the Saliva of Vampire Bats (Desmodus rotundus)

H. Hemker, S. Béguin, J. Holt, 1995, Thrombosis and Haemostasis.

Mode of action of heparin and related drugs.

H. Hemker, S. Béguin, 1991, Seminars in thrombosis and hemostasis.

Clot Promoting Effect of Platelet-Vessel wall Interaction

H. Hemker, G. Hornstra, 1979, Thrombosis and Haemostasis.

Development of a sensitive and rapid chromogenic factor IX assay for clinical use.

H. Hemker, R. Wagenvoord, H. Hendrix, 1990, Haemostasis.

An investigation of the coagulological potential of the venoms of some Central Asian snakes

H. Hemker, J. Rosing, G. Tans, 1993, Chemistry of Natural Compounds.

Prothrombin Contributes to the Assembly of the Factor Va-Factor Xa Complex at Phosphatidylserine-containing Phospholipid Membranes (*)

H. Hemker, G. Willems, T. Lindhout, 1995, The Journal of Biological Chemistry.

Procoagulant activities in venoms from central Asian snakes.

H. Hemker, J. Rosing, G. Tans, 1991, Toxicon : official journal of the International Society on Toxinology.

Title Page / Table of Contents / Preface

F. Sofi, R. Abbate, P. Morange, 2003, Pathophysiology of Haemostasis and Thrombosis.

The contribution of the various phosphorylating steps in the respiratory chain to the dinitrophenol-induced ATPase of rat-liver mitochondria.

H. Hemker, 1963, Biochimica et biophysica acta.

Development of a rapid and sensitive chromogenic heparin assay for clinical use.

H. Hemker, R. Wagenvoord, H. Hendrix, 1993, Haemostasis.

Mode of Action of Annexin V (Vascular Anticoagulant Alpha), a Protein Synthesized by the Vessel Wall

H. Hemker, C. Reutelingsperger, H. Andree, 1990 .

The Thrombogram in Rare Inherited Coagulation Disorders: Its Relation to Clinical Bleeding

Flora Peyvandi, H. Hemker, R. al Dieri, 2002, Thrombosis and Haemostasis.

Evaluation of thrombin generating capacity in plasma from patients with haemophilia A and B

H. Hemker, R. al Dieri, S. Béguin, 2005, Thrombosis and Haemostasis.

Kinetics of the inhibition of human factor Xa by full-length and truncated recombinant tissue factor pathway inhibitor.

H. Hemker, G. Willems, T. Lindhout, 1994, The Biochemical journal.

Effects of Protein S and Factor Xa on Peptide Bond Cleavages during Inactivation of Factor Va and Factor VaR506Q by Activated Protein C (*)

H. Hemker, G. Nicolaes, J. Rosing, 1995, The Journal of Biological Chemistry.

Spectrophotometric method for the assay of human blood coagulation factor VIII.

H. Hemker, M. V. van Dieijen-Visser, J. Franssen, 1987, Haemostasis.

Thrombin Generation in Plasma: Its Assessment Via the Endogenous Thrombin Potential

H C Hemker, H. Hemker, S. Béguin, 1995, Thrombosis and Haemostasis.

Activation of factor X and its regulation by tissue factor pathway inhibitor in small-diameter capillaries lined with human endothelial cells.

H. Hemker, P. Schoen, O. Nordfang, 1992, Blood.

Platelet membrane involvement in blood coagulation.

H. Hemker, J. Rosing, R. Zwaal, 1983, Blood cells.

Generation of prothrombin-converting activity and the exposure of phosphatidylserine at the outer surface of platelets.

H. Hemker, P. Comfurius, E. Bevers, 1982, European journal of biochemistry.

The Mode of Action of Heparin in Plasma

H. Hemker, S. Béguin, T. Lindhout, 1988, Thrombosis and Haemostasis.

The adsorption of prothrombin to phospholipid monolayers quantitated by ellipsometry.

H. Hemker, J. Kop, W. Hermens, 1984, The Journal of biological chemistry.

The role of phospholipid and factor VIIIa in the activation of bovine factor X.

H. Hemker, J. Rosing, G. Tans, 1981, The Journal of biological chemistry.

The role of phospholipids and factor Va in the prothrombinase complex.

H C Hemker, J Rosing, H. Hemker, 1980, The Journal of biological chemistry.

An inhibitor of clot formation in cord plasma.

H. Hemker, B. Kirchhof, A. Muller, 1979, Thrombosis research.

Heparin-like inhibitor of blood coagulation in normal newborn

H. Hemker, A. Muller, J. M. Doorm, 1977, Nature.

Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers.

H C Hemker, H. Hemker, G. Willems, 1990, The Journal of biological chemistry.

Proposal for standardized preanalytical and analytical conditions for measuring thrombin generation in hemophilia: communication from the SSC of the ISTH

H. Hemker, C. Négrier, A. Wolberg, 2017, Journal of thrombosis and haemostasis : JTH.

The pathways of blood coagulation

H. C. Hemker, H. Hemker, 1967 .

Treatment of haemophilia A with purified factor 8 obtained from human plasma by cryoprecipitation.

H. Hemker, J. Veltkamp, E. Loeliger, 1967, Folia medica Neerlandica.

Feedback mechanisms in coagulation.

H C Hemker, H. Hemker, H Kessels, 1991, Haemostasis.

Functional properties of human factor Va lacking the Asp683-Arg709 domain of the heavy chain.

H. Hemker, J. Rosing, R. Ebberink, 1994, The Journal of biological chemistry.

Analysis of thrombin generation in plasma.

H C Hemker, H. Hemker, G. Willems, 1994, Computers in biology and medicine.

Molecular interaction and transport limitation in macromolecular binding to surfaces

P. Hemker, H. Hemker, W. Hermens, 2018, bioRxiv.

Inhibition of adenosine triphosphatase and respiration of rat-liver mitochondria by dinitrophenols

H. Hemker, 1964 .

Partial purification of bovine liver vitamin K‐dependent carboxylase by immunospecific adsorption onto antifactor X

H. Hemker, C. Vermeer, A. J. Slotboom, 1981, FEBS letters.

The role of gamma-carboxyglutamyl residues in the positive cooperative binding of Ca2+ to blood coagulation factor X.

H. Hemker, M. Lindhout, 1978, Biochimica et biophysica acta.

In vitro prothrombin synthesis from a purified precursor protein. II. Partial purification of bovine carboxylase.

H. Hemker, C. Vermeer, B. Soute, 1978, Biochimica et biophysica acta.

Purification and properties of the phenprocoumon-induced decarboxyfactor X from bovine plasma. A comparison to normal factor X.

H. Hemker, J. Kop, B. Kop-Klaassen, 1978, Biochimica et biophysica acta.

In vitro prothrombin synthesis from a purified precursor protein. I. Development of a bovine liver cell-free system.

H. Hemker, C. Vermeer, J. Govers-Riemslag, 1976, Biochimica et biophysica acta.

Additional Evidence for the Existence of a Precursor Molecule of the Prothrombin Complex in Oral Anticoagulation

H. Hemker, J. Veltkamp, E. Loeliger, 1971, Thrombosis and Haemostasis.

Two Types of Prothrombin in Vitamin K Deficiency

H. Hemker, E. Loeliger, A. Muller, 1970, Thrombosis and Haemostasis.

VITAMIN-K DEFICIENCY IN THE NEWBORN

H. Hemker, J. M. Doorm, 1977, The Lancet.

The mechanism of action of oral anticoagulants and its consequences for the practice of oral anticoagulation.

H. Hemker, H. Frank, 1985, Haemostasis.

CRYOPRECIPITATES IN CLASSICAL HÆMOPHILIA

H. Hemker, J. Veltkamp, E. Loeliger, 1967 .

Synthesis of peptide p-nitroanilides mimicking fibrinogen- and hirudin-binding to thrombin. Design of slow reacting thrombin substrates.

H. Hemker, D. Rijkers, G. I. Tesser, 2009, International journal of peptide and protein research.

Design and synthesis of thrombin substrates with modified kinetic parameters.

H. Hemker, D. Rijkers, G. I. Tesser, 1995, Thrombosis research.

A century of heparin: past, present and future

H. Hemker, H. Hemker, 2016, Journal of thrombosis and haemostasis : JTH.

Binding of vascular anticoagulant a(VAC)a to Planar Phospholipid Bilayers

H. Hemker, W. Hermens, R. Hauptmann, 1990 .

A comparison between vitamin K-dependent carboxylase from normal and warfarin-treated cows.

H. Hemker, C. Vermeer, B. Soute, 1982, Biochimica et biophysica acta.

The action of Echis carinatus venom on the blood coagulation system. Demonstration of an activator of factor X.

P. Devilee, H. Hemker, M. V. van Dam-Mieras, 1984, Thrombosis research.

Purification and characterization of multisquamase, the prothrombin activator present in Echis multisquamatus venom.

H. Hemker, J. Rosing, J. Govers-Riemslag, 1997, Thrombosis research.

Activation of decarboxyfactor X by a protein from Russell's viper venom. Purification and partial characterization of activated decarboxyfactor X.

H. Hemker, B. Kop-Klaassen, M. Lindhout, 1978, Biochimica et biophysica acta.

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

H. Hemker, O. Soehnlein, G. Nicolaes, 2014, Blood.

Identification of phospholipid as an essential part of bovine vitamin K-dependent carboxylase.

H. Hemker, C. Vermeer, B. Soute, 1981, The Journal of biological chemistry.

In vitro prothrombin synthesis from a purified precursor protein. III. Preparation of an acid-soluble substrate for vitamin K-dependent carboxylase by limited proteolysis of bovine descarboxyprothrombin.

H. Hemker, C. Vermeer, H. Lijnen, 1981, Biochimica et biophysica acta.

Inhibition of enzymes by Atebrin.

H. Hemker, W. Huelsmann, 1960, Biochimica et biophysica acta.

A non-linear reaction scheme of blood coagulation

H. C. Hemker, A.C.W. Swart, H. Hemker, 1974 .

Platelets in Thrombotic and Non-thrombotic Disorders: Platelet procoagulant activities: the amplification loops between platelets and the plasmatic clotting system

H. Hemker, 2002 .

In situ-generated thrombin is the only enzyme that effectively activates factor VIII and factor V in thromboplastin-activated plasma.

H. Hemker, J. Pieters, T. Lindhout, 1989, Blood.

The Adsorption of Coagulation Factors onto Phospholipids

P. Devilee, H. Hemker, M. Kahn, 1970, Thrombosis and Haemostasis.

Ratios of anti‐factor Xa to antithrombin activities of heparins as determined in recalcified human plasma

H. Hemker, P. Schoen, Theo Lindhoux, 1992, British journal of haematology.

BLOOD COAGULATION FACTORS AT PHOSPHOLIPID SURFACES

H. Hemker, C. Vermeer, M. J. Lindhout, 1977 .

Kinetics of the formation of the factor X activating enzyme of the blood coagulation system.

H. Hemker, K. Váradi, 1976, Thrombosis research.

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

H. Hemker, A. Muller, 1968, Thrombosis and Haemostasis.

Handbook of Synthetic Substrates

H. Hemker, 1983, Springer Netherlands.

H. The Kinetics of Enzyme Cascade Systems General kinetics of enzyme cascades

P. W. Hemker, H. C. Hemker, givenName surName, 1969, Proceedings of the Royal Society of London. Series B. Biological Sciences.

Physiologie de la coagulation

H. Hemker, M. Kahn, 1976 .

The Biological Half-Time of Hageman Factor

H. Hemker, J. Veltkamp, E. Loeliger, 1965, Thrombosis and Haemostasis.

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

H. Hemker, C. Vermeer, J. Govers-Riemslag, 1977, Thrombosis and Haemostasis.

Demonstration of three proteins induced by vitamin K absence (PIVKAs)

H. Hemker, P. Reekers, M. Lindhout, 1973 .

Use of chromogenic peptide substrates in the determination of clotting factors II, VII, IX and X in normal plasma and in plasma of patients treated with oral anticoagulants.

H. Hemker, J. Rosing, M. V. van Dieijen-Visser, 1982, Haemostasis.

Control of anticoagulant therapy with a chromogenic substrate.

H. Hemker, B. Kirchhof, C. Vermeer, 1979, Haemostasis.

THE PROLONGATION OF THE THROMBOTEST CLOTTING TIME IN NEWBORNS

P. Devilee, H. Hemker, K. Hamulýak, 1988, Thrombosis and Haemostasis.

HEPARIN-LIKE INHIBITOR, NOT VITAMIN-K DEFICIENCY, IN THE NEWBORN

H. Hemker, A. Muller, J. M. Doorm, 1977, The Lancet.

A Method for Measuring Activated Factor VIII in Plasma

H. Hemker, S. Béguin, R. Wagenvoord, 1991, Thrombosis and Haemostasis.

Inhibition of activated factors II, VII, IX, and X by synthetic organic compounds directed against the active-site seryl residue.

J. A. van der Woerd-de Lange, H. Hemker, M. V. van Dam-Mieras, 1981, Haemostasis.

Chromogenic Factor IX Assay for Clinical Use

H. Hemker, R. Wagenvoord, H. Hendrix, 2022 .

Thrombin generation and inactivation in the presence of antithrombin III and heparin.

D. Baruch, H. Hemker, P. Schoen, 1986, Biochemistry.

A Computer Assisted Method to Obtain the Prothrombin Activation Velocity in Whole Plasma Independent of Thrombin Decay Processes

H. Hemker, S. Béguin, G. Willems, 1986, Thrombosis and Haemostasis.

Determination of low molecular weight heparin in clinical laboratory.

H. Hemker, M. Beunis, M. van De Ruit, 1984, Haemostasis.

The ex Vivo Correlate of the Antithrombotic Action of Heparin

H. Hemker, S. Béguin, J. Pieters, 1989, Annals of the New York Academy of Sciences.

The Inactivation of Factor VIII in Vitro

H. Hemker, J. Stibbe, S. Creveld, 1972, Thrombosis and Haemostasis.

Paratopic interaction, a mechanism in the generation of structure bound enzymatic activity

H. Hemker, H. Frank, 1977, Experientia.

Factor Va-factor Xa interaction. Effects of phospholipid vesicles of varying composition.

H C Hemker, J Rosing, H. Hemker, 1982, Biochemistry.

The role of blood clotting factor V in the conversion of prothrombin and a decarboxy prothrombin into thrombin.

H. Hemker, J. Kop, C. Vermeer, 1978, Biochimica et biophysica acta.

The kinetic behaviour of active sites present in a structured environment

H. Hemker, H. Frank, 1978 .

Prothrombin and related coagulation factors

H. Hemker, J. Veltkamp, 1975 .

Demonstration of three anomalous plasma proteins induced by a vitamin K antagonist.

H. Hemker, P. Reekers, B. Kop-Klaassen, 1973, Biochimica et biophysica acta.

Studies on Blood Coagulation Factor V

H. Hemker, M. Kahn, 1972, Thrombosis and Haemostasis.

Studies on blood coagulation factor V. VI. The inactivation of factor V and prothrombinase.

H. Hemker, M. Kahn, 1972, Thrombosis et diathesis haemorrhagica.

Studies on Blood Coagulation Factor V

H. Hemker, M. Kahn, 1969, Thrombosis and Haemostasis.

Artificial Reagents for Factor VII and Factor X, a Computer Programme for Obtaining Reference Tables for One-Stage Determinations in the Extrinsic System

H. Hemker, A. Swart, A. Alink, 1972, Thrombosis and Haemostasis.

Filipin as a Tool for the Study of Blood Coagulation Reactions

H. Hemker, L. Kraan, P. M. van der Plas, 1972, Thrombosis and Haemostasis.

Development of a simple chromogenic factor VIII assay for clinical use.

H. Hemker, R. Wagenvoord, H. Hendrix, 1989, Haemostasis.

Studies on blood coagulation factor V : III kinetics of the estimation of factor V

H. Hemker, M. Kahn, 1970 .

Enzyme Kinetic Evaluation of Coagulation Systems

H. Hemker, 1969 .

The placental transport of [3H] vitamin K1 in rats

H. Hemker, K. Hamulýak, C. Vermeer, 1987, British journal of haematology.

Lack of PIVKA effect in the abnormal factor X (factor X Friuli) coagulation disorder.

H. Hemker, A. Girolami, A. Muller, 1972, Haemostasis.

Behaviour of Factors II, VII, IX and X in Bleeding Complications During Long-Term Treatment with Coumarin

H. Hemker, A. Hensen, E. Loeliger, 1963, Thrombosis and Haemostasis.

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

P. Hemker, H. Hemker, E. Loeliger, 1965, Thrombosis and Haemostasis.

Autoactivation of human blood coagulation factor XII on dextran derivatives of different molecular weight.

H. Hemker, J. Nigretto, G. Tans, 1992, Thrombosis research.

Quantitation in Cardiology

P. Hugenholtz, H. Hemker, J. .. Bemmel, 1971, Boerhaave Series for Postgraduate Medical Education.

Topological and kinetic aspects of phospholipids in blood coagulation

Robert F. A. Zwaal, J. Rosing, Guido Tans, 1980 .

The Haemophiliac in the Eighties

R. Abbate, G. Gensini, H. Hemker, 1982 .

Dinitrophenol-induced ATPase of rat-liver mitochondria.

H. Hemker, W. Hulsmann, 1961, Biochimica et biophysica acta.

On the procoagulant activity of platelets stimulated by collagen and thrombin.

H. Hemker, P. Comfurius, E. Bevers, 1984, Thrombosis Research.

Circulating active von Willebrand factor levels are increased in chronic kidney disease and end-stage renal disease

H. Hemker, R. van Horssen, D. Huskens, 2019, Clinical kidney journal.

The Adsorption of Blood Coagulation Factors II, VII, IX and X from Human Plasma to Aluminium Hydroxide

H. Hemker, A. Swart, B. H. Klaassen, 1972, Thrombosis and Haemostasis.

Surface exclusion and molecular mobility may explain Vroman effects in protein adsorption.

H. Hemker, G. Willems, W. Hermens, 1991, Journal of biomaterials science. Polymer edition.

The adsorption of prothrombin to phosphatidylserine multilayers quantitated by ellipsometry.

H C Hemker, H. Hemker, J. Kop, 1983, The Journal of biological chemistry.

Ellipsometry as a tool to study protein films at liquid-solid interfaces.

H C Hemker, H. Hemker, W. Hermens, 1978, Analytical biochemistry.

Standard and Method Independent Units for Heparin Anticoagulant Activities

H. Hemker, S. Béguin, 1993, Thrombosis and Haemostasis.

Monitoring of unbound protein in vesicle suspensions with off-null ellipsometry.

H. Hemker, G. Willems, W. Hermens, 1993, Biochimica et biophysica acta.

The inhibition of blood coagulation by heparins of different molecular weight is caused by a common functional motif—the C‐domain

H. Hemker, R. al Dieri, S. Béguin, 2003, Journal of thrombosis and haemostasis : JTH.

Thrombin–Fibrin(ogen) Interactions, Host Defense and Risk of Thrombosis

H. Hemker, H. ten Cate, Y. Henskens, 2021, International journal of molecular sciences.

Simultaneous measurement of thrombin generation and fibrin formation in whole blood under flow conditions

H. Hemker, M. Lancé, D. Huskens, 2016, Thrombosis and Haemostasis.

Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

H. Hemker, J. Rosing, J. Govers-Riemslag, 1998, Biochemistry.

Separation of blood coagulation factors II, VII, IX and X by gel filtration in the presence of dextran blue.

H. Hemker, A. Swart, 1970, Biochimica et biophysica acta.

Whole-blood thrombin generation monitored with a calibrated automated thrombogram-based assay.

H. Hemker, Y. Dargaud, M. Ninivaggi, 2012, Clinical chemistry.

Studies on the mechanism of the vitamin K-dependent carboxylation reaction. Carboxylation without the concurrent formation of vitamin K 2,3-epoxide.

H. Hemker, C. Vermeer, R. Fokkens, 1982, The Journal of biological chemistry.

Pharmacological aspects of vitamin K1. A clinical and experimental study in man.

H. Hemker, J. van der Meer, E. Loeliger, 1968, Thrombosis et diathesis haemorrhagica. Supplementum.

Data management in thrombin generation.

H. Hemker, R. Kremers, 2013, Thrombosis research.

Factor IX concentrate : Preparation by a simple method and clinical use

H. Hemker, A. Swart, P. Bruning, 1970 .

Heparin neutralization during collection and processing of blood inhibited by pyridoxal 5'-phosphate.

H. Hemker, M. Beunis, M. van De Ruit, 1984, Haemostasis.

Automated determination of heparin with chromogenic substrates.

H. Hemker, M. Beunis, M. van De Ruit, 1984, Haemostasis.

Laboratory Control of Oral Anticoagulants

H. Hemker, J. Veltkamp, E. Loeliger, 1970, Thrombosis and Haemostasis.

The mode of action of dinitrophenols on the different phosphorylating steps

H. Hemker, 1964 .

Reconstitution and lipid requirements of porcine tissue thromboplastin.

H. Hemker, L. van Deenen, G. Wijngaards, 1977, Biochimica et biophysica acta.

Determination of tissue thromboplastin activity.

H. Hemker, G. Wijngaards, 1977, Haemostasis.

Large inter-individual variation of the pharmacodynamic effect of anticoagulant drugs on thrombin generation

H. Hemker, S. Bloemen, R. A. Dieri, 2013, Haematologica.

Production of thrombin as a probe for mixing of phospholipids in membranes on solid supports.

H. Hemker, W. Hermens, P. Giesen, 1995, Biochimica et biophysica acta.

[Thrombosis and thrombin].

H. Hemker, S. Béguin, 1992, Annales pharmaceutiques francaises.

The Mode of Action of Low Molecular Weight Heparin Preparation (PK10169) and Two of its Major Components on Thrombin Generation in Plasma

H. Hemker, S. Béguin, T. Lindhout, 1989, Thrombosis and Haemostasis.

THE ACTION OF HEPARIN IN PLASMA

H. Hemker, 1987 .

Interindividual variation in relationships between plasma heparin concentration and the results of five heparin assays.

H. Hemker, M. Beunis, M. van De Ruit, 1982, Clinica chimica acta; international journal of clinical chemistry.

Mode of action of enoxaparin in plasma.

H. Hemker, S. Béguin, 1990, Acta chirurgica Scandinavica. Supplementum.

Critical Perceptions on Problem-based Learning

H. Hemker, 2001, European Review.

Protein C activation by an activator purified from the venom of Agkistrodon halys halys

H. Hemker, R. Bertina, J. Rosing, 1993, Blood Coagulation and Fibrinolysis.

Membrane-mediated assembly of the prothrombinase complex.

H. Hemker, G. Willems, W. Hermens, 1991, The Journal of biological chemistry.

Thrombin generation: biochemical possibilities and clinical reality.

H. Hemker, C. Hemker, 2015, Blood.

Vitamin K-dependent carboxylase: the carboxylation of exogenous substrates in different systems.

H. Hemker, C. Vermeer, B. Soute, 1985, Biochimica et biophysica acta.

Role of accessory components in the activation of vitamin K-dependent coagulation factors.

H. Hemker, J. Rosing, R. Zwaal, 1986, Haemostasis.

The Activity of Heparin in the Presence and Absence of Ca2+ Ions; why the Anti-Xa Activity of LMW Heparins Is about two Times Overestimated

H. Hemker, S. Béguin, 1993, Thrombosis and Haemostasis.

Simulation model for thrombin generation in plasma.

H C Hemker, H. Hemker, G. Willems, 1991, Haemostasis.

The biochemistry of blood coagulation

H. Hemker, 1982 .

Lipid solubility as a factor influencing the activity of uncoupling phenols.

H. Hemker, 1962, Biochimica et biophysica acta.

Kinetic Aspects of the Interaction of Blood Clotting Enzymes

H. Hemker, J. Kop, G. Willems, 1979, Thrombosis and Haemostasis.

Editorial Note reduction of infarct size: discrepancies between experimental work and clinical application

H. Hemker, W. Hermens, 1983 .

Inhibition of factor IXa and factor Xa by antithrombin III/heparin during factor X activation.

H. Hemker, J. Pieters, G. Willems, 1988, The Journal of biological chemistry.

Adsorption Kinetics of Protein Mixtures A Tentative Explanation of the Vroman Effect

H. Hemker, G. Willems, W. Hermens, 1987, Annals of the New York Academy of Sciences.

Good Mathematical Practice: Simulation of the Hemostatic-Thrombotic Mechanism, a Powerful Tool but One That Must Be Used with Circumspection

H. Hemker, F. Ataullakhanov, 2006, Pathophysiology of Haemostasis and Thrombosis.

Isolation and purification of proteins induced by vitamin K absence

H. Hemker, P. Reekers, 1974 .

The synthesis of prothrombin from its precursor protein.

H. Hemker, C. Vermeer, B. Soute, 1978, Bibliotheca haematologica.

The carboxylation of prothrombin precursors in a bovine liver cell-free system

H. Hemker, C. Vermeer, M. Metz, 1980 .

Computer evaluation of reference curves for the estimation of extrinsic coagulation factors.

H L Frank, V Dreessen, H C Hemker, 1978, Computers in biology and medicine.

The estimation of activated human blood coagulation factor VII

H. Hemker, A. Muller, R. Gonggrijp, 1922 .

vitro and improves survival in sepsis Nonanticoagulant heparin prevents histone-mediated cytotoxicity in

C. Reutelingsperger, H. Hemker, O. Soehnlein, 2014 .

The adsorption of prothrombin to phosphatidylserine multilayers quantitated by ellipsometry.

H. Hemker, J. Kop, W. Hermens, 1983, The Journal of biological chemistry.

Pathophysiological and Clinical Aspects of Venous and Arterial Thrombosis

H. Hemker, S. Levy‐toledano, 1999, Pathophysiology of Haemostasis and Thrombosis.

Linear diffusion of thrombin and factor Xa along the heparin molecule explains the effects of extended heparin chain lengths.

H. Hemker, R. al Dieri, S. Béguin, 2008, Thrombosis research.

Prothrombinase is protected from inactivation by tissue factor pathway inhibitor: competition between prothrombin and inhibitor.

H. Hemker, G. Willems, T. Wun, 1997, The Biochemical journal.

Protein C activation by an activator purified from the venom of Agkistrodon halys halys

H. Hemker, R. Bertina, J. Rosing, 1993, Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis.

Activation of Coagulation and Fibrinolysis during Maximal Physical Exercise

P. Devilee, H. Hemker, E. Brommer, 1984 .

In memory of François Josso. Why do hemophiliacs bleed?

H. Hemker, 2009, Scandinavian journal of haematology. Supplementum.

Purification of blood coagulation factors II, VII, IX and X from bovine citrated plasma.

H. Hemker, P. Reekers, 1972, Haemostasis.

Improvements of the method for the preparation of an artificial prothrombin reagent.

H. Hemker, C. Vermeer, B. Soute, 1978, Thrombosis Research.

The Evaluation of the Two-Stage Prothrombin Assay

P. Hemker, P. Devilee, H. Hemker, 1971, Thrombosis and Haemostasis.

Discrepancies between the one- and two-stage prothrombin estimations in purified prothrombin preparations

H. Hemker, A. Muller, 1975 .

Artificial Reagents for Factor VII and Factor X, a Computer Programme for Obtaining Reference Tables for One-Stage Determinations in the Extrinsic System

H. Hemker, A. Swart, A. Alink, 1972, Thrombosis and Haemostasis.

Contact Activation in the Extrinsic Blood Clotting System

H. Hemker, R. Altman, 1967, Thrombosis and Haemostasis.