S. Heximer

发表

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

J. M. Wyss, J. Penninger, S. Heximer, 2003, The Journal of clinical investigation.

Rab Family Proteins Regulate the Endosomal Trafficking and Function of RGS4*

S. Heximer, Guillaume Bastin, 2013, The Journal of Biological Chemistry.

Tumor Necrosis Factor-&agr;–Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure

S. Heximer, D. Lidington, J. Kroetsch, 2012, Circulation.

Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model.

S. Nattel, J. Tardif, S. Heximer, 2013, Journal of the American College of Cardiology.

Early Stress Prevents the Potentiation of Muscarinic Excitation by Calcium Release in Adult Prefrontal Cortex

E. Lambe, S. Heximer, D. Suri, 2014, Biological Psychiatry.

Controlling Parasympathetic Regulation of Heart Rate: A Gatekeeper Role for RGS Proteins in the Sinoatrial Node

S. Heximer, Alexandra S Mighiu, A. Mighiu, 2012, Front. Physio..

Proximal Cerebral Arteries Develop Myogenic Responsiveness in Heart Failure via Tumor Necrosis Factor-&agr;–Dependent Activation of Sphingosine-1-Phosphate Signaling

R. Henkelman, S. Heximer, D. Lidington, 2012, Circulation.

A candidate hypertension gene: will SPON1 hold salt and water?

S. Heximer, M. Husain, 2007, Circulation research.

The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice

R. Seeley, D. Drucker, S. Heximer, 2017, Molecular metabolism.

RGS4-Deficiency Alters Intracellular Calcium and PKA-Mediated Control of Insulin Secretion in Glucose-Stimulated Beta Islets

S. Heximer, M. Wheeler, Guillaume Bastin, 2021, Biomedicines.

Mechanism of action of glucagon-like peptide-2 to increase IGF-I mRNA in intestinal subepithelial fibroblasts.

D. Storm, S. Heximer, A. Izzo, 2011, Endocrinology.

The effect of insulin to decrease neointimal growth after arterial injury is endothelial nitric oxide synthase-dependent.

I. G. Fantus, V. Dolinsky, V. Rao, 2015, Atherosclerosis.

Type VIII collagen mediates vessel wall remodeling after arterial injury and fibrous cap formation in atherosclerosis.

S. Heximer, R. Assoian, G. Hou, 2013, The American journal of pathology.

Catharanthine Dilates Small Mesenteric Arteries and Decreases Heart Rate and Cardiac Contractility by Inhibition of Voltage-Operated Calcium Channels on Vascular Smooth Muscle Cells and Cardiomyocytes

S. Heximer, P. Backx, S. Kanthan, 2013, The Journal of Pharmacology and Experimental Therapeutics.

B-Cell Deficiency Lowers Blood Pressure in Mice

C. Simmons, Michelle B. Chen, S. Heximer, 2019, Hypertension.

Tumor Necrosis Factor- (cid:1) –Mediated Downregulation of the Cystic Fibrosis Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Signaling in a Mouse Model of Heart Failure

S. Heximer, D. Lidington, J. Kroetsch, 2022 .

Metoprolol impairs resistance artery function in mice.

W. Beattie, C. Mazer, David F Wilson, 2011, Journal of applied physiology.

RGS Proteins: Swiss Army Knives in Seven-Transmembrane Domain Receptor Signaling Networks

S. Heximer, K. Blumer, 2007, Science's STKE.

Role of Sphingosine-1-Phosphate Phosphohydrolase 1 in the Regulation of Resistance Artery Tone

S. Spiegel, H. Bolz, S. Heximer, 2008, Circulation research.

Signaling in a Mouse Model of Heart Failure Transmembrane Conductance Regulator Drives Pathological Sphingosine-1-Phosphate Mediated Downregulation of the Cystic Fibrosis − α Tumor Necrosis Factor

S. Heximer, D. Lidington, J. Kroetsch, 2012 .

A "new twist" on RGS protein selectivity.

S. Heximer, 2013, Structure.

RGS4 controls Gαi3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes

S. Heximer, Guillaume Bastin, Alex L. C. Tam, 2020, Journal of Cell Science.

Mechanisms Governing Subcellular Localization and Function of Human RGS2*

S. Heximer, K. Blumer, H. Lim, 2001, The Journal of Biological Chemistry.

Alternative Translation Initiation of Human Regulators of G-Protein Signaling-2 Yields a Set of Functionally Distinct Proteins

C. Dessauer, S. Heximer, K. Blumer, 2007, Molecular Pharmacology.

G Protein-Coupled Receptor Signaling and Sphingosine-1-Phosphate Play a Phylogenetically Conserved Role in Endocrine Pancreas Morphogenesis (cid:1)

S. Heximer, D. Beis, A. Gavalas, 2011 .

Regulator of G protein signaling 5 protects against cardiac hypertrophy and fibrosis during biomechanical stress of pressure overload

S. Heximer, Q. Tang, Chengwei He, 2010, Proceedings of the National Academy of Sciences.

Unique Hydrophobic Extension of the RGS2 Amphipathic Helix Domain Imparts Increased Plasma Membrane Binding and Function Relative to Other RGS R4/B Subfamily Members*

S. Heximer, R. Natesh, J. Hepler, 2007, Journal of Biological Chemistry.

Amino-terminal Cysteine Residues Differentially Influence RGS4 Protein Plasma Membrane Targeting, Intracellular Trafficking, and Function*

S. Heximer, Guillaume Bastin, K. Dissanayake, 2012, The Journal of Biological Chemistry.

Myocardial Infarction Induces Cardiac Fibroblast Transformation within Injured and Noninjured Regions of the Mouse Heart.

B. Hinz, A. Gramolini, S. Heximer, 2021, Journal of proteome research.

A "stealth" approach to inhibition of lymphocyte activation by oligonucleotide complementary to the putative G0/G1 switch regulatory gene G0S30/EGR1/NGFI-A.

S. Heximer, D. Forsdyke, A. Cristillo, 1996, DNA and cell biology.

Genetic evidence for the requirement of adenylyl cyclase 1 in synaptic scaling of forebrain cortical neurons

M. Zhuo, S. Heximer, Hansen Wang, 2007, The European journal of neuroscience.

Enhanced proliferation and altered calcium handling in RGS2-deficient vascular smooth muscle cells

S. Heximer, Hangjun Zhang, A. Momen, 2014, Journal of receptor and signal transduction research.

c-Myb–Dependent Inositol 1,4,5-Trisphosphate Receptor Type-1 Expression in Vascular Smooth Muscle Cells

S. Heximer, M. Husain, T. Afroze, 2007, Arteriosclerosis, thrombosis, and vascular biology.

G Protein Selectivity Is a Determinant of RGS2 Function*

S. Heximer, K. Blumer, J. Hepler, 1999, The Journal of Biological Chemistry.

Iron Overload Decreases CaV1.3-Dependent L-Type Ca2+ Currents Leading to Bradycardia, Altered Electrical Conduction, and Atrial Fibrillation

S. Heximer, J. Striessnig, R. Rose, 2011, Circulation. Arrhythmia and electrophysiology.

A human gene encoding a putative basic helix-loop-helix phosphoprotein whose mRNA increases rapidly in cycloheximide-treated blood mononuclear cells.

S. Heximer, D. Siderovski, D. Forsdyke, 1994, DNA and cell biology.

A human putative lymphocyte G0/G1 switch gene homologous to a rodent gene encoding a zinc-binding potential transcription factor.

S. Heximer, D. Forsdyke, 1993, DNA and cell biology.

Cyclosporin A inhibits early mRNA expression of G0/G1 switch gene 2 (G0S2) in cultured human blood mononuclear cells.

S. Heximer, D. Forsdyke, A. Cristillo, 1997, DNA and cell biology.

Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells.

S. Heximer, D. Forsdyke, A. Cristillo, 1997, DNA and cell biology.

Sequence analysis and expression in cultured lymphocytes of the human FOSB gene (G0S3).

S. Heximer, D. Forsdyke, A. Cristillo, 1996, DNA and cell biology.

Constitutive smooth muscle tumour necrosis factor regulates microvascular myogenic responsiveness and systemic blood pressure

S. Heximer, S. Offermanns, D. Lidington, 2017, Nature Communications.

Priming of hypoxia-inducible factor by neuronal nitric oxide synthase is essential for adaptive responses to severe anemia

R. Henkelman, C. Mazer, S. Heximer, 2011, Proceedings of the National Academy of Sciences.

The normal copy of the G0S19-3-associated, CpG island-containing, upstream sequence is downstream of G0S19-2/MIP1alpha in association with a TRE17 oncogene.

S. Heximer, D. Forsdyke, L. Russell, 1998, DNA and cell biology.

Genetic Deletion of Regulator of G-protein Signaling 4 (rgs4) Rescues a Subset of Fragile X Related Phenotypes in the Fmr1 Knockout Mouse Keywords: Autism Fragile X Syndrome Gaba B Regulator of G Protein Signaling 4 G-protein Coupled Receptor

D. Kooy, S. Heximer, D. Hampson, 2022 .

Increased GABAB Receptor-Mediated Signaling Reduces the Susceptibility of Fragile X Knockout Mice to Audiogenic Seizures

David R. Hampson, S. Heximer, D. Hampson, 2009, Molecular Pharmacology.

Resveratrol Inhibits Neointimal Growth after Arterial Injury in High-Fat-Fed Rodents: The Roles of SIRT1 and AMPK

V. Dolinsky, S. Heximer, M. McBurney, 2020, Journal of Vascular Research.

The primary benefits of angiotensin-converting enzyme inhibition on cardiac remodeling occur during sleep time in murine pressure overload hypertrophy.

Rachel D. Vanderlaan, S. Heximer, N. Khaper, 2011, Journal of the American College of Cardiology.

CFTR Therapeutics Normalize Cerebral Perfusion Deficits in Mouse Models of Heart Failure and Subarachnoid Hemorrhage

S. Heximer, D. Lidington, J. Kroetsch, 2019, JACC. Basic to translational science.

Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

Attila Kovacs, Kendall J Blumer, Dean Y. Li, 2003, The Journal of clinical investigation.

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

R. Karas, S. Heximer, K. Kaltenbronn, 2003, Nature Medicine.

Origin‐specific epigenetic program correlates with vascular bed‐specific differences in Rgs5 expression

S. Heximer, S. Tirgari, Hangjun Zhang, 2012, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression and processing of G0/G1 switch gene 24 (G0S24/TIS11/TTP/NUP475) RNA in cultured human blood mononuclear cells.

S. Heximer, D. Forsdyke, A. Cristillo, 1998, DNA and cell biology.

Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition

A. Gramolini, S. Heximer, R. Mecham, 2021, Matrix biology plus.

Nanoscale reorganization of sarcoplasmic reticulum in pressure-overload cardiac hypertrophy visualized by dSTORM

C. Simmons, A. Gramolini, S. Heximer, 2019, Scientific Reports.

RGS2/G0S8 is a selective inhibitor of Gqα function

S. Heximer, K. Blumer, J. Hepler, 1997 .

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

J. Penninger, S. Heximer, R. Knutsen, 2003, The Journal of clinical investigation.

Deficiency of Natriuretic Peptide Receptor 2 Promotes Bicuspid Aortic Valves, Aortic Valve Disease, Left Ventricular Dysfunction, and Ascending Aortic Dilatations in Mice

R. Henkelman, C. Simmons, S. Heximer, 2017, Circulation research.

The RGS2 Gene Product from a Candidate Hypertension Allele Shows Decreased Plasma Membrane Association and Inhibition of Gq

S. Heximer, S. Tirgari, S. Gu, 2008, Molecular Pharmacology.

RGS4 Regulates Parasympathetic Signaling and Heart Rate Control in the Sinoatrial Node

S. Heximer, S. Bolz, Hangjun Zhang, 2008, Circulation Research.

β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids

S. Heximer, D. Siderovski, R. Leigh, 2011, Proceedings of the National Academy of Sciences.

Intracellular regulation of heterotrimeric G-protein signaling in normal and diseased tissues of the cardiovascular system

S. Heximer, 2012 .

Intracellular regulation of heterotrimeric G-protein signaling modulates vascular smooth muscle cell contraction.

S. Heximer, Guillaume Bastin, 2011, Archives of biochemistry and biophysics.

RGS proteins: identifying new GAPs in the understanding of blood pressure regulation and cardiovascular function.

S. Heximer, Carlo Cifelli, Sean Wang, 2009, Clinical science.

RGS2/G0S8 is a selective inhibitor of Gqalpha function.

S. Heximer, K. Blumer, J. Hepler, 1997, Proceedings of the National Academy of Sciences of the United States of America.

G Protein-Coupled Receptor Signaling and Sphingosine-1-Phosphate Play a Phylogenetically Conserved Role in Endocrine Pancreas Morphogenesis

S. Heximer, D. Beis, A. Gavalas, 2011, Molecular and Cellular Biology.

Hypertension‐evoked RhoA activity in vascular smooth muscle cells requires RGS5

T. Wieland, M. Hecker, S. Heximer, 2017, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

G-protein signaling participates in the development of diabetic cardiomyopathy.

S. Heximer, K. Kaltenbronn, Anthony J. Muslin, 2004, Diabetes.

Experimental Subarachnoid Hemorrhage Drives Catecholamine-Dependent Cardiac and Peripheral Microvascular Dysfunction

S. Heximer, D. Lidington, J. Kroetsch, 2020, Frontiers in Physiology.

Resveratrol inhibits neointimal formation after arterial injury through an endothelial nitric oxide synthase-dependent mechanism.

V. Dolinsky, J. Dyck, S. Heximer, 2012, Atherosclerosis.

RGS2-mediated regulation of Gqalpha.

S. Heximer, 2004, Methods in enzymology.

Kv4.3-Encoded Fast Transient Outward Current Is Presented in Kv4.2 Knockout Mouse Cardiomyocytes

Kyoung-Han Kim, C. Hui, S. Heximer, 2015, PloS one.

Defining the mechanisms by which palmitoylation regulates the localization and function of RGS4

S. Heximer, Guillaume Bastin, K. Dissanayake, 2010 .

The RGS2 Gene Product from a Candidate Hypertension Allele Shows Decreased Plasma Membrane Association and Inhibition of Gq

S. Heximer, S. Tirgari, S. Gu, 2008, Molecular Pharmacology.

L‐Tryptophan ethyl ester dilates small mesenteric arteries by inhibition of voltage‐operated calcium channels in smooth muscle

S. Heximer, J. Kroetsch, Guillaume Bastin, 2012, British journal of pharmacology.

Genetic deletion of regulator of G-protein signaling 4 (RGS4) rescues a subset of fragile X related phenotypes in the FMR1 knockout mouse

D. Kooy, S. Heximer, D. Hampson, 2011, Molecular and Cellular Neuroscience.

Role of Sphingosine-1-Phosphate Phosphohydrolase 1 in the Regulation of Resistance Artery Tone

S. Spiegel, H. Bolz, S. Heximer, 2008, Circulation research.

Iron Overload Decreases CaV1.3-Dependent L-Type Ca2+ Currents Leading to Bradycardia, Altered Electrical Conduction, and Atrial Fibrillation

S. Heximer, J. Striessnig, R. Rose, 2011, Circulation. Arrhythmia and electrophysiology.

Chronic Iron-overload Causes Sinus Bradycardia By Altering Electrical Activity In Sinoatrial Node Myocytes

S. Heximer, R. Rose, P. Backx, 2009 .

Defining Transcriptomic Heterogeneity between Left and Right Ventricle-Derived Cardiac Fibroblasts

S. Heximer, Dylan Langburt, Haisam Shah, 2024, Cells.

Gαi3-Dependent Inhibition of JNK Activity on Intracellular Membranes

S. Heximer, Guillaume Bastin, Jin Yang, 2015, Front. Bioeng. Biotechnol..

Disrupting circadian control of peripheral myogenic reactivity mitigates cardiac injury following myocardial infarction

J. Hanchard, S. Heximer, D. Lidington, 2022, Cardiovascular research.