K. Blumer

发表

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

J. M. Wyss, J. Penninger, S. Heximer, 2003, The Journal of clinical investigation.

Mot3, a Zn finger transcription factor that modulates gene expression and attenuates mating pheromone signaling in Saccharomyces cerevisiae.

K. Blumer, A. Grishin, M. Rothenberg, 1998, Genetics.

The p21-activated Protein Kinase-related Kinase Cla4 Is a Coincidence Detector of Signaling by Cdc42 and Phosphatidylinositol 4-Phosphate*

Kendall J Blumer, K. Blumer, M. Lemmon, 2004, Journal of Biological Chemistry.

G-protein-coupled receptors function as oligomers in vivo

K. Blumer, M. C. Overton, Mark C. Overton, 2000, Current Biology.

Oligomerization of G-Protein-Coupled Receptors: Lessons from the Yeast Saccharomyces cerevisiae

K. Blumer, M. C. Overton, Sharon L Chinault, 2005, Eukaryotic Cell.

Pak-Family Kinases Regulate Cell and Actin Polarization Throughout the Cell Cycle of Saccharomyces cerevisiae

K. Blumer, S. Holly, 1999, Journal of Cell Biology.

Phage fl mRNA processing in Escherichia coli: search for the upstream products of endonuclease cleavage, requirement for the product of the altered mRNA stability (ams) locus.

K. Blumer, D. Steege, R. Kokoska, 1990, Biochimie.

An Allosteric Regulator of R7-RGS Proteins Influences Light-Evoked Activity and Glutamatergic Waves in the Inner Retina

K. Blumer, A. Kolesnikov, D. Kerschensteiner, 2013, PloS one.

Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

G. Bowman, K. Blumer, Sukrit Singh, 2018 .

Autonomic nervous system and blood pressure regulation in RGS 2-deficient mice

A. Diedrich, J. Tank, R. Plehm, 2005 .

Functional Expression of Mammalian Receptors and G-Proteins in Yeast

K. Blumer, 1993 .

Targeting nucleotide exchange to inhibit constitutively active G protein α subunits in cancer cells

J. Cooper, K. Kaltenbronn, K. Blumer, 2018, Science Signaling.

A WASp-binding type II phosphatidylinositol 4-kinase required for actin polymerization-driven endosome motility

G. Carman, K. Blumer, G. Han, 2005, The Journal of cell biology.

Up-Regulation of Regulator of G Protein Signaling 4 Expression in a Model of Neuropathic Pain and Insensitivity to Morphine

M. Rhee, K. Blumer, M. Scheideler, 2003, Journal of Pharmacology and Experimental Therapeutics.

Upregulation of RGS4 expression in a model of neuropathic pain and insensitivity to morphine

M. Rhee, K. Blumer, M. Scheideler, 2002 .

A Syntaxin Homolog Encoded by VAM3 Mediates Down-regulation of a Yeast G Protein-coupled Receptor*

K. Blumer, C. Stefan, 1999, The Journal of Biological Chemistry.

Mechanism of RGS4, a GTPase-activating Protein for G Protein α Subunits*

K. Blumer, M. C. Overton, Sreesha P. Srinivasa, 1998, The Journal of Biological Chemistry.

RGS4 reduces contractile dysfunction and hypertrophic gene induction in Galpha q overexpressing mice.

G. Dorn, Anthony J. Muslin, K. Blumer, 2001, Journal of molecular and cellular cardiology.

RGS4 inhibits G-protein signaling in cardiomyocytes.

Anthony J. Muslin, K. Blumer, P. Tamirisa, 1999, Circulation.

Use of fluorescence resonance energy transfer to analyze oligomerization of G-protein-coupled receptors expressed in yeast.

K. Blumer, M. C. Overton, 2002, Methods.

Macrophage secretion of miR-106b-5p causes renin-dependent hypertension

R. Knutsen, R. Mecham, K. Blumer, 2020, Nature Communications.

Expression of GTPase-deficient Giα2 Results in Translocation of Cytoplasmic RGS4 to the Plasma Membrane*

Dennis Brown, K. Blumer, K. Druey, 1998, The Journal of Biological Chemistry.

A Mechanism Regulating G Protein-coupled Receptor Signaling That Requires Cycles of Protein Palmitoylation and Depalmitoylation* ♦

Brent R. Martin, K. Blumer, S. Mennerick, 2014, The Journal of Biological Chemistry.

RGS2 is a primary terminator of β₂-adrenergic receptor-mediated G(i) signaling.

D. Kass, E. Lakatta, Xianhua Wang, 2011, Journal of molecular and cellular cardiology.

RGS family members: GTPase-activating proteins for heterotrimeric G-protein alpha-subunits.

K. Blumer, K. Druey, J. Kehrl, 1996, Nature.

Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae.

K. Blumer, M. Linder, Sreesha P. Srinivasa, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Hypotension Due to Kir6.1 Gain‐of‐Function in Vascular Smooth Muscle

Anlong Li, R. Knutsen, R. Mecham, 2013, Journal of the American Heart Association.

Depalmitoylation Requires Cycles of Protein Palmitoylation Protein-coupled Receptor Signaling That A Mechanism Regulating G Signal Transduction :

Brent R. Martin, K. Blumer, S. Mennerick, 2014 .

GIRK channel modulation by assembly with allosterically regulated RGS proteins

K. Kaltenbronn, K. Blumer, S. Mennerick, 2012, Proceedings of the National Academy of Sciences.

Gi/o Signaling and the Palmitoyltransferase DHHC2 Regulate Palmitate Cycling and Shuttling of RGS7 Family-binding Protein*

K. Blumer, M. Linder, Lixia Jia, 2011, The Journal of Biological Chemistry.

RGS3 and RGS4 are GTPase activating proteins in the heart.

J. Rottman, Anthony J. Muslin, K. Blumer, 1998, Journal of molecular and cellular cardiology.

The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization.

K. Blumer, C. Stefan, 1994, Molecular and cellular biology.

The third cytoplasmic loop of a yeast G-protein-coupled receptor controls pathway activation, ligand discrimination, and receptor internalization

K. Blumer, C. Stefan, 1994 .

A WASp Homolog Powers Actin Polymerization-Dependent Motility of Endosomes In Vivo

K. Blumer, C. Stefan, F. S. Chang, 2003, Current Biology.

C5a Receptor Oligomerization FLUORESCENCE RESONANCE ENERGY TRANSFER STUDIES OF A HUMAN G PROTEIN-COUPLED RECEPTOR EXPRESSED IN YEAST*

K. Blumer, T. Baranski, M. C. Overton, 2003 .

The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain.

J. Thorner, K. Blumer, W. Courchesne, 1988, Cell.

Control of adaptation to mating pheromone by G protein beta subunits of Saccharomyces cerevisiae.

K. Blumer, J. Weiner, A. Grishin, 1994, Genetics.

Translational control of phage f1 gene expression by differential activities of the gene V, VII, IX and VIII initiation sites.

K. Blumer, D. Steege, M. R. Ivey, 1987, Journal of molecular biology.

Genetic ablation of calcium-independent phospholipase A(2)beta causes hypercontractility and markedly attenuates endothelium-dependent relaxation to acetylcholine.

K. Kaltenbronn, K. Blumer, R. Gross, 2010, American journal of physiology. Heart and circulatory physiology.

mRNA processing in Escherichia coli: an activity encoded by the host processes bacteriophage f1 mRNAs.

K. Blumer, D. Steege, 1984, Nucleic acids research.

Palmitoylation regulates plasma membrane–nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family

Maureen P. Boyle, L. Muglia, K. Blumer, 2005, The Journal of cell biology.

Chloroquine Sensitizes GNAQ/11-mutated Melanoma to MEK1/2 Inhibition

S. Odelberg, M. McMahon, K. Blumer, 2020, Clinical Cancer Research.

Association of p62, a multifunctional SH2- and SH3-domain-binding protein, with src family tyrosine kinases, Grb2, and phospholipase C gamma-1

K. Blumer, A. Shaw, D. Yu, 1995, Molecular and cellular biology.

Subunits of a Yeast Oligomeric G Protein-coupled Receptor Are Activated Independently by Agonist but Function in Concert to Activate G Protein Heterotrimers*

K. Blumer, M. C. Overton, Sharon L Chinault, 2004, Journal of Biological Chemistry.

RGS Proteins: Swiss Army Knives in Seven-Transmembrane Domain Receptor Signaling Networks

S. Heximer, K. Blumer, 2007, Science's STKE.

Sympathetic nerve traffic and circulating norepinephrine levels in RGS2-deficient mice

A. Diedrich, J. Tank, J. Jordan, 2007, Autonomic Neuroscience.

Mechanisms Governing Subcellular Localization and Function of Human RGS2*

S. Heximer, K. Blumer, H. Lim, 2001, The Journal of Biological Chemistry.

Alternative Translation Initiation of Human Regulators of G-Protein Signaling-2 Yields a Set of Functionally Distinct Proteins

C. Dessauer, S. Heximer, K. Blumer, 2007, Molecular Pharmacology.

RGS proteins inhibit Xwnt-8 signaling in Xenopus embryonic development.

Anthony J. Muslin, K. Blumer, C. Wu, 2000, Development.

Disruption of receptor-G protein coupling in yeast promotes the function of an SST2-dependent adaptation pathway.

K. Blumer, J. Weiner, C. Guttierez-Steil, 1993, The Journal of biological chemistry.

Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C.

K. Blumer, G. Johnson, C. Lange-Carter, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Mechanisms governing the activation and trafficking of yeast G protein-coupled receptors.

K. Blumer, C. Stefan, M. C. Overton, 1998, Molecular biology of the cell.

The carboxy-terminal segment of the yeast α-factor receptor is a regulatory domain

J. Thorner, K. Blumer, W. Courchesne, 1988, Cell.

Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13

K. Kaltenbronn, K. Blumer, Matthew D. Cain, 2017, The Journal of Biological Chemistry.

Hypotension Due to Kir 6 . 1 Gain-of-Function in Vascular Smooth Muscle

Anlong Li, R. Knutsen, R. Mecham, 2013 .

yeast guanine nucleotide-binding protein are not essential for membrane association of the a subunit but are required for receptor coupling

K. Blumer, Jeremy THORNERt, 2022 .

Oligomerization, Biogenesis, and Signaling Is Promoted by a Glycophorin A-like Dimerization Motif in Transmembrane Domain 1 of a Yeast G Protein-coupled Receptor*

K. Blumer, M. C. Overton, Sharon L Chinault, 2003, Journal of Biological Chemistry.

RGS2-deficient mice exhibit decreased intraocular pressure and increased retinal ganglion cell survival

D. Epstein, K. Blumer, P. Rao, 2009, Molecular vision.

G Protein Selectivity Is a Determinant of RGS2 Function*

S. Heximer, K. Blumer, J. Hepler, 1999, The Journal of Biological Chemistry.

The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae.

J. Thorner, K. Blumer, J. Reneke, 1988, The Journal of biological chemistry.

Regulation of Renal Hemodynamics and Function by RGS2

K. Blumer, S. Eguchi, Harpreet Singh, 2015, PloS one.

Altered reactivity of resistance vasculature contributes to hypertension in elastin insufficiency.

R. Knutsen, R. Mecham, K. Blumer, 2014, American journal of physiology. Heart and circulatory physiology.

Developmental adaptation of the mouse cardiovascular system to elastin haploinsufficiency.

Attila Kovacs, Kendall J Blumer, Dean Y. Li, 2003, The Journal of clinical investigation.

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

K. Blumer, K. Druey, J. Kehrl, 1996, Nature.

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

K. Blumer, K. Druey, J. Kehrl, 1996, Nature.

The Extracellular N-terminal Domain and Transmembrane Domains 1 and 2 Mediate Oligomerization of a Yeast G Protein-coupled Receptor*

Kendall J Blumer, K. Blumer, M. C. Overton, 2002, The Journal of Biological Chemistry.

Regulator of G-protein signaling-2 mediates vascular smooth muscle relaxation and blood pressure

R. Karas, S. Heximer, K. Kaltenbronn, 2003, Nature Medicine.

Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin.

K. Blumer, Markus Gödel, A. Shaw, 2006, The Journal of clinical investigation.

Diversity in function and regulation of MAP kinase pathways.

K. Blumer, G. Johnson, G. Johnson, 1994, Trends in biochemical sciences.

Dual Lipid Modification Motifs in Gα and Gγ Subunits Are Required for Full Activity of the Pheromone Response Pathway in Saccharomyces cerevisiae

K. Blumer, M. Linder, M. Patnana, 2000 .

Targeting primary and metastatic uveal melanoma with a G protein inhibitor

J. Cooper, K. Kaltenbronn, K. Blumer, 2021, bioRxiv.

Oncogenic Gq/11 signaling acutely drives and chronically sustains metabolic reprogramming in uveal melanoma

J. Ippolito, K. Kaltenbronn, K. Blumer, 2021, The Journal of biological chemistry.

Simulation of spontaneous G protein activation reveals a new intermediate driving GDP unbinding

Gregory R Bowman, Xianqiang Sun, Sukrit Singh, 2018, bioRxiv.

Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gβ5 complexes in brain

Y. Smith, K. Kaltenbronn, K. Blumer, 2008, Neuroscience.

RGS2/G0S8 is a selective inhibitor of Gqα function

S. Heximer, K. Blumer, J. Hepler, 1997 .

Breast Cancer Cell Targeting by Prenylation Inhibitors Elucidated in Living Animals with a Bioluminescence Reporter

K. Kaltenbronn, K. Blumer, D. Piwnica-Worms, 2012, Clinical Cancer Research.

Reporter Elucidated in Living Animals with a Bioluminescence Breast Cancer Cell Targeting by Prenylation Inhibitors

K. Kaltenbronn, K. Blumer, D. Piwnica-Worms, 2012 .

Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice.

J. Penninger, S. Heximer, R. Knutsen, 2003, The Journal of clinical investigation.

R9AP and R7BP: traffic cops for the RGS7 family in phototransduction and neuronal GPCR signaling.

K. Blumer, M. Jayaraman, Lixia Jia, 2009, Trends in pharmacological sciences.

RGS2 Is a Mediator of Nitric Oxide Action on Blood Pressure and Vasoconstrictor Signaling

Xiaoguang Sun, K. Kaltenbronn, T. Steinberg, 2005, Molecular Pharmacology.

Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling.

J. Thorner, K. Blumer, J Thorner, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Functional domains of a peptide hormone receptor: the alpha-factor receptor (STE2 gene product) of the yeast Saccharomyces cerevisiae.

J. Thorner, K. Blumer, W. Courchesne, 1988, Cold Spring Harbor Symposia on Quantitative Biology.

Receptor-G protein signaling in yeast.

J. Thorner, K. Blumer, 1991, Annual review of physiology.

Functional expression of the yeast alpha-factor receptor in Xenopus oocytes.

J. Thorner, N. Davidson, K. Blumer, 1989, The Journal of biological chemistry.

Regulator of G Protein Signaling 2 Deficiency Causes Endothelial Dysfunction and Impaired Endothelium-derived Hyperpolarizing Factor-mediated Relaxation by Dysregulating Gi/o Signaling*

M. Chapleau, K. Kaltenbronn, M. Rhee, 2012, The Journal of Biological Chemistry.

RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload.

Anthony J. Muslin, K. Blumer, D. Kelly, 1999, The Journal of clinical investigation.

Actin-based motility during endocytosis in budding yeast.

J. Cooper, K. Blumer, Kyoungtae Kim, 2005, Molecular biology of the cell.

Biochemical and genetic analysis of dominant-negative mutations affecting a yeast G-protein gamma subunit

K. Blumer, J. Weiner, A. Grishin, 1994, Molecular and cellular biology.

Go ahead, break my symmetry!

J. Cooper, K. Blumer, 2003, Nature Cell Biology.

C5a Receptor Oligomerization

Kendall J Blumer, K. Blumer, T. Baranski, 2003, Journal of Biological Chemistry.

The C-terminal Tail Preceding the CAAX Box of a Yeast G Protein γ Subunit Is Dispensable for Receptor-mediated G Protein Activation in Vivo*

K. Blumer, Sharon L Chinault, 2003, Journal of Biological Chemistry.

Regulation of RGS2 and Second Messenger Signaling in Vascular Smooth Muscle Cells by cGMP-dependent Protein Kinase*

Xiaoguang Sun, T. Steinberg, K. Blumer, 2007, Journal of Biological Chemistry.

Regulator of G Protein Signaling 2: A Versatile Regulator of Vascular Function.

K. Blumer, P. Osei-Owusu, 2015, Progress in molecular biology and translational science.

RGS2/G0S8 is a selective inhibitor of Gqalpha function.

S. Heximer, K. Blumer, J. Hepler, 1997, Proceedings of the National Academy of Sciences of the United States of America.

R7BP Augments the Function of RGS7·Gβ5 Complexes by a Plasma Membrane-targeting Mechanism*

K. Kaltenbronn, K. Blumer, A. Buchwalter, 2006, Journal of Biological Chemistry.

Toward the Selective Inhibition of G Proteins: Total Synthesis of a Simplified YM-254890 Analog.

K. Blumer, Sakshi Uppal, K. Moeller, 2015, Organic letters.

G-protein signaling participates in the development of diabetic cardiomyopathy.

S. Heximer, K. Kaltenbronn, Anthony J. Muslin, 2004, Diabetes.

NO-dependent Blood Pressure Regulation in RGS2-deficient Mice: P178

A. Diedrich, J. Tank, R. Plehm, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Autonomic nervous system and blood pressure regulation in RGS2-deficient mice.

Jens Jordan, Jens Tank, Kendall J Blumer, 2005, American journal of physiology. Regulatory, integrative and comparative physiology.

Selective expression of regulators of G-protein signaling (RGS) in the human central nervous system.

C. Larminie, P. Murdock, K. Blumer, 2004, Brain research. Molecular brain research.

Negative regulation of alpha2-adrenergic receptor-mediated Gi signalling by a novel pathway.

K. Blumer, T. Nagao, H. Kurose, 1999, The Biochemical journal.

Actin cytoskeleton organization regulated by the PAK family of protein kinases

M. Peter, D. Drubin, K. Blumer, 1998, Current Biology.

Novel functions of clathrin light chains: clathrin heavy chain trimerization is defective in light chain-deficient yeast.

K. Blumer, C. Stefan, S. Lemmon, 1997, Journal of cell science.

Dual lipid modification motifs in G(alpha) and G(gamma) subunits are required for full activity of the pheromone response pathway in Saccharomyces cerevisiae.

K. Blumer, M. Linder, M. Patnana, 2000, Molecular biology of the cell.

Vision: The need for speed

Kendall J. Blumer, K. Blumer, 2004, Nature.

Gi/o Signaling and the Palmitoyltransferase DHHC2 Regulate Palmitate Cycling and Shuttling of RGS7 Family-binding Protein*

K. Blumer, M. Linder, Lixia Jia, 2011, The Journal of Biological Chemistry.

Palmitoylation regulates plasma membrane–nuclear shuttling of R7BP, a novel membrane anchor for the RGS7 family

Maureen P. Boyle, L. Muglia, K. Blumer, 2005, The Journal of cell biology.

NO-dependent blood pressure regulation in RGS2-deficient mice.

A. Diedrich, J. Tank, R. Plehm, 2006, American journal of physiology. Regulatory, integrative and comparative physiology.

Regulation of neurite morphogenesis by interaction between R7 regulator of G protein signaling complexes and G protein subunit Gα13

K. Kaltenbronn, K. Blumer, Matthew D. Cain, 2017, The Journal of Biological Chemistry.