I. Hassinen

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Phylogenetic network of the mtDNA haplogroup U in Northern Finland based on sequence analysis of the complete coding region by conformation-sensitive gel electrophoresis.

L. Ala‐Kokko, S. Finnilä, K. Majamaa, 2000, American journal of human genetics.

Regulation of palmitoylcarnitine oxidation in isolated rat liver mitochondria. Role of the redox state of NAD(H).

J. Hiltunen, I. Hassinen, P. Latipää, 1986, Biochimica et biophysica acta.

Effect of prolonged ethanol ingestion on hepatic lipogenesis and related enzyme activities.

J. Hiltunen, M. Savolainen, I. Hassinen, 1977, The Biochemical journal.

Mechanisms for the effects of ethanol on hepatic phosphatidate phosphohydrolase.

M. Savolainen, I. Hassinen, 1978, The Biochemical journal.

Hormonal regulation of hepatic soluble phosphatidate phosphohydrolase

M. Savolainen, I. Hassinen, M. Lehtonen, 1979, FEBS letters.

Precursor supply and hepatic enzyme activities as regulators of triacylglycerol synthesis in isolated hepatocytes and perfused liver.

M. Savolainen, I. Hassinen, A. H. Pikkukangas, 1982, Archives of biochemistry and biophysics.

Oxygen and substrate dependence of hepatic cellular respiration: Sinusoidal oxygen gradient and effects of ethanol in isolated perfused liver and hepatocytes

I. Hassinen, E. M. Kekonen, V. P. Jauhonen, 1987, Journal of cellular physiology.

The glutamate dehydrogenase system and the redox state of mitochondrial free nicotinamide adenine dinucleotide in myocardium

J. Hiltunen, I. Hassinen, E. Nuutinen, 1981, FEBS letters.

Subcellular distribution of phosphagens in isolated perfused rat heart

R. Kauppinen, J. Hiltunen, I. Hassinen, 1980, FEBS letters.

Ischemia stimulates the release of atrial natriuretic peptide from rat cardiac ventricular myocardium in vitro.

I. Hassinen, O. Vuolteenaho, K. Peuhkurinen, 1992, Life sciences.

Analysis of functional consequences of haplogroup J polymorphisms m.4216T>C and m.3866T>C in human MT-ND1: mutagenesis of homologous positions in Escherichia coli.

S. Finnilä, K. Majamaa, I. Hassinen, 2010, Mitochondrion.

Elimination and replenishment of tricarboxylic acid-cycle intermediates in myocardium.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1981, The Biochemical journal.

Mitochondrial transmembrane proton electrochemical potential, di- and tricarboxylate distribution and the poise of the malate-aspartate cycle in the intact myocardium.

R. Kauppinen, J. Hiltunen, I. Hassinen, 1986, Advances in experimental medicine and biology.

Mitochondrial respiratory control in the myocardium.

I. Hassinen, 1986, Biochimica et biophysica acta.

Compartmentation of citrate in relation to the regulation of glycolysis and the mitochondrial transmembrane proton electrochemical potential gradient in isolated perfused rat heart.

R. Kauppinen, J. Hiltunen, I. Hassinen, 1982, Biochimica et biophysica acta.

The known purified mammalian 2,4-dienoyl-CoA reductases are mitochondrial isoenzymes.

J. Hiltunen, I. Hassinen, R. Sormunen, 1989, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

Reversible ischemic inhibition of F(1)F(0)-ATPase in rat and human myocardium.

I. Hassinen, K. Peuhkurinen, K. Kiviluoma, 2001, Biochimica et biophysica acta.

Effect of chronic hypoxia on hepatic triacylglycerol concentration and mitochondrial fatty acid oxidizing capacity in liver and heart.

I. Hassinen, V. Kinnula, 1978, Acta Physiologica Scandinavica.

Signaling and Regulation Through the NAD+ and NADP+ Networks.

I. Hassinen, 2017, Antioxidants & redox signaling.

Epidemiology of the mitochondrial DNA 8344A>G mutation for the myoclonus epilepsy and ragged red fibres (MERRF) syndrome

K. Majamaa, I. Hassinen, S. Karvonen, 2003, Journal of neurology, neurosurgery, and psychiatry.

Role of pyruvate carboxylation in the energy-linked regulation of pool sizes of tricarboxylic acid-cycle intermediates in the myocardium.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1982, The Biochemical journal.

Pyruvate carboxylation as an anaplerotic mechanism in the isolated perfused rat heart.

I. Hassinen, K. Peuhkurinen, 1982, The Biochemical journal.

Role of NADP+ (corrected)-linked malic enzymes as regulators of the pool size of tricarboxylic acid-cycle intermediates in the perfused rat heart.

J. Hiltunen, I. Hassinen, J. Heikkilä, 1987, The Biochemical journal.

Pyruvate carboxylation in the rat heart. Role of biotin-dependent enzymes.

J. Hiltunen, I. Hassinen, K. Sundqvist, 1989, The Biochemical journal.

Efflux of adenosine and total adenylate catabolites during alterations of the cellular energy state. An NMR study of continuous and discontinuous ischemia

I. Hassinen, K. Peuhkurinen, K. Kiviluoma, 1995, Basic Research in Cardiology.

Oxidation-reduction midpoint potentials of mitochondrial flavoproteins and their intramitochondrial localization

I. Hassinen, H. Voltti, 1978, Journal of bioenergetics and biomembranes.

Myocardial preservation during coronary surgery with and without cardiopulmonary bypass.

I. Hassinen, K. Peuhkurinen, K. Kiviluoma, 2001, The Annals of thoracic surgery.

Adenine nucleotide transport and adenosine production in isolated rat heart mitochondria during acetate metabolism.

I. Hassinen, K. Peuhkurinen, K. Kiviluoma, 1989, Biochimica et biophysica acta.

Intracellular free calcium and mitochondrial membrane potential in ischemia/reperfusion and preconditioning.

I. Hassinen, K. Peuhkurinen, K. Ylitalo, 2000, Journal of molecular and cellular cardiology.

Ischaemic preconditioning and a mitochondrial KATP channel opener both produce cardioprotection accompanied by F1F0-ATPase inhibition in early ischaemia

I. Hassinen, K. Ylitalo, A. Ala-Rämi, 2003, Basic Research in Cardiology.

Generation of reactive oxygen species by human mesothelioma cells

I. Hassinen, V. Kinnula, K. Linnainmaa, 1999, British Journal of Cancer.

Novel variants and phenotypes widen the phenotypic spectrum of GABRG2-related disorders

K. Pylkäs, J. Schreiber, I. Hassinen, 2019, Seizure.

Increase of blood NAD+ and attenuation of lactacidemia during nicotinamide treatment of a patient with the MELAS syndrome.

K. Majamaa, I. Hassinen, A. Remes, 1996, Life sciences.

Acetate-induced changes in cardiac energy metabolism and hemodynamics in the rat

I. Hassinen, K. Peuhkurinen, K. Kiviluoma, 1988, Basic Research in Cardiology.

Cellular source and role of adenosine in isoproterenol-induced coronary vasodilatation.

I. Hassinen, K. Peuhkurinen, M. J. Pekka Raatikainen, 1991, Journal of molecular and cellular cardiology.

Hypoxia stimulates release of ANP and BNP from perfused rat ventricular myocardium.

I. Hassinen, O. Vuolteenaho, J. Leppäluoto, 1994, The American journal of physiology.

Childhood Encephalopathies and Myopathies: A Prospective Study in a Defined Population to Assess the Frequency of Mitochondrial Disorders

K. Majamaa, I. Hassinen, A. Remes, 2000, Pediatrics.

Hearts of Hypoxia-inducible Factor Prolyl 4-Hydroxylase-2 Hypomorphic Mice Show Protection against Acute Ischemia-Reperfusion Injury*

I. Hassinen, K. Kivirikko, R. Sormunen, 2010, The Journal of Biological Chemistry.

Endothelin-induced atrial natriuretic peptide release from cultured neonatal cardiac myocytes: the role of extracellular calcium and protein kinase-C.

I. Hassinen, O. Vuolteenaho, H. Ruskoaho, 1992, Endocrinology.

Metabolic compartmentation of pyruvate in the isolated perfused rat heart.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1983, The Biochemical journal.

Myocardial glucose uptake in patients with the m.3243A > G mutation in mitochondrial DNA

P. Iozzo, J. Knuuti, K. Majamaa, 2016, Journal of Inherited Metabolic Disease.

Evaluating clinical mitochondrial respiratory chain enzymes from biopsy specimens presenting skewed probability distribution of activity data.

P. Nieminen, I. Hassinen, H. Rantala, 2016, Mitochondrion.

Hearing impairment in patients with 3243A→G mtDNA mutation: phenotype and rate of progression

K. Majamaa, I. Hassinen, M. Sorri, 2001, Human Genetics.

Modification of metabolic effects of ethanol by fructose.

I. Hassinen, R. Ylikahri, M. Kähönen, 2009, Acta medica Scandinavica. Supplementum.

Adult‐onset diabetes mellitus and neurosensory hearing loss in maternal relatives of MELAS patients in a family with the tRNALeu(UUR) mutation

K. Majamaa, I. Hassinen, A. Remes, 1993, Neurology.

Mitochondrial membrane potential, transmembrane difference in the NAD+ redox potential and the equilibrium of the glutamate-aspartate translocase in the isolated perfused rat heart.

R. Kauppinen, J. Hiltunen, I. Hassinen, 1983, Biochimica et biophysica acta.

Energy-linked regulation of glucose and pyruvate oxidation in isolated perfused rat heart. Role of pyruvate dehydrogenase.

J. Hiltunen, I. Hassinen, 1976, Biochimica et biophysica acta.

Adaptive changes in gluconeogenic enzymes in rat liver and kidney during long-term ethanol ingestion.

J. Hiltunen, M. Savolainen, I. Hassinen, 1978, Metabolism: clinical and experimental.

Effect of hypoxia on mitochondrial mass and cytochrome concentrations in rat heart and liver during postnatal development.

I. Hassinen, V. Kinnula, 1977, Acta physiologica Scandinavica.

Regulation of pyruvate dehydrogenase during infusion of fatty acids of varying chain lengths in the perfused rat heart.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1985, Journal of molecular and cellular cardiology.

Energy-linked regulation of the citric acid cycle and the pool size of the cycle intermediates in the isolated perfused rat heart

J. Hiltunen, I. Hassinen, 1977 .

Effects of clofibrate on ethanol-induced modifications in liver and adipose tissue metabolism: role of hepatic redox state and hormonal mechanisms.

M. Savolainen, I. Hassinen, V. P. Jauhonen, 1977, Biochemical pharmacology.

Mechanism of fatty acid effect on myocardial oxygen consumption. A phosphorus NMR study.

B. Chance, S. Nioka, I. Hassinen, 1990, Biochimica et biophysica acta.

Increased prolyl 4-hydroxylase activity in the myocardium of endurance-trained mice

T. Takala, I. Hassinen, H. Kainulainen, 1983, Experientia.

Transmural distribution of biochemical markers of total protein and collagen synthesis, myocardial contraction speed and capillary density in the rat left ventricle in angiotensin II-induced hypertension.

T. Takala, I. Hassinen, H. Ruskoaho, 1988, Acta physiologica Scandinavica.

Hepatic triacylglycerol and fatty-acid biosynthesis during hypoxia in vivo.

M. Savolainen, I. Hassinen, V. Kinnula, 1978, Acta physiologica Scandinavica.

Effects of ethanol metabolites on intermediary metabolism in heart muscle

J. Hiltunen, T. Takala, I. Hassinen, 1983, Pharmacology Biochemistry and Behavior.

Tricarboxylic acid cycle metabolites during ischemia in isolated perfused rat heart.

T. Takala, I. Hassinen, K. Peuhkurinen, 1983, The American journal of physiology.

Evaluation of reperfusion strategy for the globally ischaemic rat heart. Recovery of function and energy metabolism.

I. Hassinen, K. Peuhkurinen, S. Haunsø, 1992, Cardiovascular research.

Effect of ethanol on hepatic phosphatidate phosphohydrolase: dose-dependent enzyme induction and its abolition by adrenalectomy and pyrazole treatment.

M. Savolainen, I. Hassinen, 1980, Archives of biochemistry and biophysics.

Dual probe fluorescence monitoring of intracellular free calcium during ischemia in mouse heart by using continuous compensation for pH dependence of the dissociation constant of Fura-2, and the interference of myoglobin.

I. Hassinen, A. Kantola, E. Liimatta, 2007, Journal of biochemical and biophysical methods.

Microcarrier Culture of Neonatal Heart Cells

I. Hassinen, P. Uusimaa, 1990 .

Demyelinating polyneuropathy in a patient with the tRNALeu(uur) mutation at base pair 3243 of the mitochondrial DNA

K. Majamaa, I. Hassinen, U. Tolonen, 1995, Neurology.

Adenosine inhibits the release of atrial natriuretic peptide from the perfused rat heart.

I. Hassinen, K. Peuhkurinen, H. Ruskoaho, 1993, European journal of pharmacology.

Effect of hypo-osmolality on atrial natriuretic peptide gene expression in neonatal cultured cardiomyocytes.

I. Hassinen, H. Ruskoaho, P. Uusimaa, 1991, Acta physiologica Scandinavica.

Association between mitochondrial DNA haplogroups J and K, serum branched-chain amino acids and lowered capability for endurance exercise

M. Perola, J. Kettunen, S. Keinänen-Kiukaanniemi, 2022, BMC Sports Science, Medicine and Rehabilitation.

Lucigenin and coelenterazine as superoxide probes in mitochondrial and bacterial membranes.

M. Finel, I. Hassinen, M. Kervinen, 2004, Analytical biochemistry.

Regulation of fatty acid oxidation in heart muscle. Effects of pyruvate and dichloroacetate.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1983, Biochimica et biophysica acta.

Cytoskeletal structure of myoblasts with the mitochondrial DNA 3243A-->G mutation and of osteosarcoma cells with respiratory chain deficiency.

K. Majamaa, I. Hassinen, J. Peltonen, 2002, Cell motility and the cytoskeleton.

Mitochondrial function determines the viability and osteogenic potency of human mesenchymal stem cells.

A. Vepsäläinen, I. Hassinen, Hannu-Ville Leskelä, 2010, Tissue engineering. Part C, Methods.

Homozygous W748S mutation in the POLG1 gene in patients with juvenile‐onset Alpers syndrome and status epilepticus

K. Majamaa, I. Hassinen, M. Röyttä, 2008, Epilepsia.

Sequence analysis of nuclear genes encoding functionally important complex I subunits in children with encephalomyopathy

K. Majamaa, I. Hassinen, A. Remes, 2005, Journal of Molecular Medicine.

Redox state ol the cellular free NAD pools, phosphorylation state of the adenylate system and the (Na+‐K+)‐stimulated ATP‐ase in rat liver

I. Hassinen, V. Kinnula, 1978 .

A subcellular study of the clofibrate-induced increase in coenzyme A concentration in rat liver.

I. Hassinen, H. Voltti, 1980, Biochemical pharmacology.

Clofibrate-induced increase in coenzyme A concentration in rat tissues.

M. Savolainen, I. Hassinen, V. P. Jauhonen, 1979, The Biochemical journal.

Effect of disulfiram (tetraethylthiuram disulfide) on mitochondrial oxidations.

I. Hassinen, 1966, Biochemical pharmacology.

The mechanism of ammonia production and the effect of mechanical work load on proteolysis and amino acid catabolism in isolated perfused rat heart.

J. Hiltunen, T. Takala, I. Hassinen, 1980, The Biochemical journal.

Effect of clofibrate on the hepatic concentrations of citric acid cycle intermediates and malonyl-CoA in the rat.

I. Hassinen, H. Voltti, 1981, Life sciences.

From identification of fluorescent flavoproteins to mitochondrial redox indicators in intact tissues

I. Hassinen, 2014 .

Reaction of dicyclohexylcarbodiimide with mitochondrial proteins.

I. Hassinen, P. T. Vuokila, 1993, Biochimica et biophysica acta.

Relationship between lipid composition and drug metabolizing capacity of human liver

M. Savolainen, I. Hassinen, E. Sotaniemi, 2004, European Journal of Clinical Pharmacology.

Metabolic interventions against complex I deficiency in MELAS syndrome

K. Majamaa, I. Hassinen, A. Remes, 1997, Molecular and Cellular Biochemistry.

β‐oxidation of polyunsaturated fatty acids in peroxisomes Subcellular distribution of Δ3,Δ2‐enoyl‐CoA isomerase activity in rat liver

J. Hiltunen, I. Hassinen, T. Kärki, 1987 .

Effect of exogenous fructose-1,6-bisphosphate on glycolysis in the isolated perfused rat heart.

I. Hassinen, E. Nuutinen, B. Giardina, 1991, American heart journal.

Mechanism of the effect of exogenous fructose 1,6-bisphosphate on myocardial energy metabolism.

B. Chance, S. Nioka, I. Hassinen, 1991, Circulation.

Further insight into mechanism of action of clodronate: inhibition of mitochondrial ADP/ATP translocase by a nonhydrolyzable, adenine-containing metabolite.

I. Hassinen, P. Lehenkari, J. Mönkkönen, 2002, Molecular pharmacology.

Role of myocardial redox and energy states in ischemia-stimulated release of atrial natriuretic peptide.

I. Hassinen, O. Vuolteenaho, K. Peuhkurinen, 1992, Journal of molecular and cellular cardiology.

The MELAS mutations 3946 and 3949 perturb the critical structure in a conserved loop of the ND1 subunit of mitochondrial complex I.

M. Finel, K. Majamaa, I. Hassinen, 2006, Human molecular genetics.

Mutagenesis of three conserved Glu residues in a bacterial homologue of the ND1 subunit of complex I affects ubiquinone reduction kinetics but not inhibition by dicyclohexylcarbodiimide.

M. Finel, I. Hassinen, S. Kurki, 2000, Biochemistry.

Effect of acetate and octanoate on tricarboxylic acid cycle metabolite disposal during propionate oxidation in the perfused rat heart.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1984, Biochimica et biophysica acta.

Delta 3,delta 2-enoyl-CoA isomerases. Characterization of the mitochondrial isoenzyme in the rat.

J. Hiltunen, I. Hassinen, R. Sormunen, 1990, The Journal of biological chemistry.

beta-Oxidation of polyunsaturated fatty acids by rat liver peroxisomes. A role for 2,4-dienoyl-coenzyme A reductase in peroxisomal beta-oxidation.

J. Hiltunen, I. Hassinen, T. Kärki, 1986, The Journal of biological chemistry.

Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy

Seppo Ylä-Herttuala, Matej Orešič, Tuulikki Seppänen-Laakso, 2008, Circulation research.

Inhibition of Hypoxia-inducible Factor (HIF) Hydroxylases by Citric Acid Cycle Intermediates

I. Hassinen, K. Kivirikko, J. Myllyharju, 2007, Journal of Biological Chemistry.

Sensitivity to NN'-dicyclohexylcarbodi-imide of proton translocation by mitochondrial NADH:ubiquinone oxidoreductase.

I. Hassinen, P. Honkakoski, 1986, Biochemical Journal.

Effects of pathogenic mutations in membrane subunits of mitochondrial Complex I on redox activity and proton translocation studied by modeling in Escherichia coli.

K. Majamaa, I. Hassinen, M. Kervinen, 2015, Mitochondrion.

Regulation of Mitochondrial Respiration in Heart Muscle

I. Hassinen, 2007 .

DCCD sensitivity of electron and proton transfer by NADH: ubiquinone oxidoreductase in bovine heart submitochondrial particles--a thermodynamic approach.

I. Hassinen, P. T. Vuokila, 1989, Biochimica et biophysica acta.

Differences between collagen hydroxylases and 2-oxoglutarate dehydrogenase in their inhibition by structural analogues of 2-oxoglutarate.

K. Majamaa, I. Hassinen, K. Kivirikko, 1985, The Biochemical journal.

Epidemiology of A3243G, the mutation for mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes: prevalence of the mutation in an adult population.

K. Majamaa, I. Hassinen, P. Salmela, 1998, American journal of human genetics.

The effect of disulfiram on the glutamic oxalacetic transaminase activity in rabbit serum.

I. Hassinen, K. Koskenvuo, 1960, Le Scalpel.

Mitochondria and Energy Metabolism: Networks, Mechanisms, and Control

I. Hassinen, 2014 .

Monitoring of mitochondrial membrane potential in isolated perfused rat heart.

R. Kauppinen, I. Hassinen, 1984, The American journal of physiology.

Role of acetaldehyde and acetate in the development of ethanol-induced cardiac lipidosis, studied in isolated perfused rat hearts.

I. Hassinen, K. Kiviluoma, 1983, Alcoholism, clinical and experimental research.

Child with Alpers-huttenlocher-like Disease a Mutation in Mitochondrial Dna-encoded Cytochrome C Oxidase Ii Gene in A

S. Finnilä, K. Majamaa, I. Hassinen, 2022 .

Modeling of human pathogenic mutations in Escherichia coli complex I reveals a sensitive region in the fourth inside loop of NuoH.

I. Hassinen, M. Kervinen, P. Maliniemi, 2009, Mitochondrion.

Regulation of cellular respiration by thyroid hormone. Spectroscopic evidence of mitochondrial control in intact rat liver.

I. Hassinen, R. Ylikahri, M. Kähönen, 1971, Archives of biochemistry and biophysics.

Studies on the mechanism of inhibition of acute alcoholic fatty liver by clofibrate.

I. Hassinen, M. Kähönen, R. H. Yilkahri, 1972, Metabolism: Clinical and Experimental.

Lysosomal and nonlysosomal hydrolases of skeletal muscle in neuromuscular diseases.

T. Takala, I. Hassinen, U. Tolonen, 1983, Archives of neurology.

Role of cellular energy state and adenosine in the regulation of coronary flow during variation in contraction frequency in an isolated perfused heart.

I. Hassinen, K. Peuhkurinen, K. Kiviluoma, 1986, Journal of molecular and cellular cardiology.

Subcellular distribution of myocardial 5'-nucleotidase.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1990, Journal of molecular and cellular cardiology.

Ethanol metabolism in rats treated with ethyl-α-p-chlorophenoxyiso-butyrate (Clofibrate)

I. Hassinen, R. Ylikahri, M. Kähönen, 1971 .

Restriction fragment analysis as a source of error in detection of heteroplasmic mtDNA mutations.

S. Finnilä, K. Majamaa, I. Hassinen, 1999, Mutation research.

Effect of Acute Pancreatitis on Porcine Intestine: A Morphological Study

J. Koskenkari, I. Hassinen, P. Lehenkari, 2013, Ultrastructural pathology.

Mitochondrial DNA deletions in dilated cardiomyopathy: a clinical study employing endomyocardial sampling.

M. Ikäheimo, I. Hassinen, K. Peuhkurinen, 1994, Journal of the American College of Cardiology.

Redistribution of glucose uptake by chronic exercise, measured in isolated perfused rat hearts

T. Takala, I. Hassinen, H. Kainulainen, 1985, Pflügers Archiv.

Acetoin as a metabolite of ethanol.

I. Hassinen, 1963, Acta physiologica Scandinavica.

A new endogenous ATP analog (ApppI) inhibits the mitochondrial adenine nucleotide translocase (ANT) and is responsible for the apoptosis induced by nitrogen‐containing bisphosphonates

I. Hassinen, P. Lehenkari, J. Mönkkönen, 2006, British journal of pharmacology.

Myocardial Overexpression of Mecr, a Gene of Mitochondrial FAS II Leads to Cardiac Dysfunction in Mouse

I. Miinalainen, J. Hiltunen, I. Hassinen, 2009, PloS one.

Metformin selectively targets redox control of complex I energy transduction

Amy R. Cameron, I. Hassinen, D. Stewart, 2017, Redox biology.

Enzymatic assay for 3-hydroxyacyl-CoA and 2-trans-enoyl-CoA intermediates of beta-oxidation.

J. Hiltunen, I. Hassinen, P. Latipää, 1988, Analytical biochemistry.

Mechanisms of ischemic preconditioning in rat myocardium. Roles of adenosine, cellular energy state, and mitochondrial F1F0-ATPase.

I. Hassinen, K. Peuhkurinen, K. Ylitalo, 1995, Circulation.

Effect of Mechanical Work Load on the Transmural Distribution of Glucose Uptake in the Isolated Perfused Rat Heart, Studied by Regional Deoxyglucose Trapping

T. Takala, I. Hassinen, 1981, Circulation research.

The common MELAS mutation A3243G in mitochondrial DNA among young patients with an occipital brain infarct

K. Majamaa, I. Hassinen, J. Turkka, 1997, Neurology.

Role of cellular energetics in ischemia-reperfusion and ischemic preconditioning of myocardium

I. Hassinen, K. Ylitalo, A. Ala-Rämi, 1998, Molecular and Cellular Biochemistry.

Mitochondrial DNA haplogroup U as a risk factor for occipital stroke in migraine

K. Majamaa, I. Hassinen, J. Turkka, 1998, The Lancet.

Plasma membrane phosphate transport and extracellular phosphate concentration in the regulation of cellular respiration in isolated perfused rat heart.

I. Hassinen, M. Nuutinen, I. E. Hassinen, 1981, Biochimica et biophysica acta.

Cardiac abnormalities in patients with mitochondrial DNA mutation 3243A>G

K. Majamaa, I. Hassinen, K. Peuhkurinen, 2002, BMC cardiovascular disorders.

DISULFIRAM AND SERUM ENZYMES.

I. Hassinen, R. Tenhunen, 1963, Scandinavian journal of clinical and laboratory investigation.

5'-Nucleotidase activity and adenosine production in rat liver mitochondria.

J. Hiltunen, I. Hassinen, K. Peuhkurinen, 1992, Biochimica et biophysica acta.

Increased activities of antioxidant enzymes and decreased ATP concentration in cultured myoblasts with the 3243A-->G mutation in mitochondrial DNA.

K. Majamaa, I. Hassinen, H. Rusanen, 2000, Biochimica et biophysica acta.

Transmural distribution of calcium accumulation and glucose uptake in the calcium paradox in the rat left ventricle.

T. Takala, I. Hassinen, J. Leipälä, 1989, Journal of molecular and cellular cardiology.

Optical monitoring of mitochondrial membrane potential in intact myocardium and its application to the development of tissue injury caused by calcium readmission to the isolated perfused heart.

I. Hassinen, 1986, Advances in experimental medicine and biology.

Respiratory control in isolated perfused rat heart. Role of the equilibrium relations between the mitochondrial electron carriers and the adenylate system.

I. Hassinen, K. Hiltunen, I. E. Hassinen, 1975, Biochimica et biophysica acta.

Respiratory control in heart muscle during fatty acid oxidation. Energy state or substrate-level regulation by Ca2+?

I. Hassinen, P. Ingman, A. Ala-Rämi, 1995, Journal of molecular and cellular cardiology.

LEBER'S HEREDITARY OPTIC NEURORETINOPATHY, A MITOCHONDRIAL DISEASE?

I. Hassinen, H. Kalimo, E. Nikoskelainen, 1984, The Lancet.

Metabolic effects of acetaldehyde in the intact rat brain cortex and its subcellular fractions.

I. Hassinen, M. Härkönen, R. Ylikahri, 1974, Brain research.

POLG1 p.R722H mutation associated with multiple mtDNA deletions and a neurological phenotype

S. Finnilä, K. Majamaa, I. Hassinen, 2010, BMC neurology.

Effects of substrate supply and aortic pressure on the transmural distribution of glucose uptake in the isolated perfused rat heart.

J. Hiltunen, T. Takala, I. Hassinen, 1984, Journal of molecular and cellular cardiology.

The NADH oxidation domain of complex I: do bacterial and mitochondrial enzymes catalyze ferricyanide reduction similarly?

M. Finel, I. Hassinen, S. Kurki, 2000, Biochimica et biophysica acta.

NN'-dicyclohexylcarbodi-imide-sensitivity of bovine heart mitochondrial NADH: ubiquinone oxidoreductase. Inhibition of activity and binding to subunits.

I. Hassinen, P. T. Vuokila, 1988, The Biochemical journal.

Comparison of the effects of disulfiram and dimercaptopropanol arsenite on mitochondrial structure and function.

I. Hassinen, M. Hallman, 1967, Biochemical pharmacology.

Postnatal development and sex differences in hepatic phosphatidate phosphohydrolase activity in the rat.

A. Ruokonen, M. Savolainen, I. Hassinen, 1981, Metabolism: clinical and experimental.

Ubiquinone and nicotinamide treatment of patients with the 3243A→G mtDNA mutation

K. Majamaa, I. Hassinen, U. Tolonen, 2002, Neurology.

Prevalence of large-scale mitochondrial DNA deletions in an adult Finnish population

K. Majamaa, I. Hassinen, P. Salmela, 2005, Neurology.

Molecular epidemiology of childhood mitochondrial encephalomyopathies in a Finnish population: sequence analysis of entire mtDNA of 17 children reveals heteroplasmic mutations in tRNAArg, tRNAGlu, and tRNALeu(UUR) genes.

S. Finnilä, K. Majamaa, I. Hassinen, 2004, Pediatrics.

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy.

Bethan E. Hoskins, D. Seelow, H. Prokisch, 2010, The Journal of clinical investigation.

Phylogenetic analysis of mitochondrial DNA in patients with an occipital stroke. Evaluation of mutations by using sequence data on the entire coding region.

S. Finnilä, K. Majamaa, I. Hassinen, 2001, Mutation research.

Polyneuropathy in the mtDNA base pair 3243 point mutation

K. Majamaa, I. Hassinen, U. Tolonen, 1996, Neurology.

Oxidation-reduction properties of the mitochondrial flavoprotein chain.

B Chance, B. Chance, I. Hassinen, 1968, Biochemical and biophysical research communications.

Effects of hypoxia and fasting on the cytochrome concentration in intestinal epithelial villous cell mitochondria. Role of changes in the life-span of the cells.

I. Hassinen, V. Kinnula, 1981, Acta physiologica Scandinavica.

Hydrogen transfer into mitochondria in the metabolism of ethanol. II. Effect of disulfiram on the hydrogen and energy transfer.

I. Hassinen, 1967, Annales medicinae experimentalis et biologiae Fenniae.

Metabolic effects of propionate, hexanoate and propionylcarnitine in normoxia, ischaemia and reperfusion. Does an anaplerotic substrate protect the ischaemic myocardium?

I. Hassinen, K. Peuhkurinen, K. Vuorinen, 1994, European heart journal.

Mitochondrial DNA deletion diagnosed by analysis of an endomyocardial biopsy specimen from a patient with Kearns-Sayre syndrome and complete heart block

K. Majamaa, I. Hassinen, K. Peuhkurinen, 1992, British heart journal.

Reflectance spectrophotometric and surface fluorometric methods for measuring the redox state of nicotinamide nucleotides and flavins in intact tissues.

I. Hassinen, 1986, Methods in enzymology.

Leber hereditary optic neuropathy mutations in the ND6 subunit of mitochondrial complex I affect ubiquinone reduction kinetics in a bacterial model of the enzyme.

M. Finel, I. Hassinen, M. Kervinen, 2008, The Biochemical journal.

A reflectance spectrophotometer-surface fluorometer suitable for monitoring changes in hemoprotein spectra and fluorescence of flavins and nicotinamide nucleotides in intact tissues.

I. Hassinen, T. Jämsä, 1982, Analytical biochemistry.

Frequency of mitochondrial DNA point mutations among patients with familial sensorineural hearing impairment

M. Lehtonen, K. Majamaa, I. Hassinen, 2000, European Journal of Human Genetics.

LHON/MELAS overlap mutation in ND1 subunit of mitochondrial complex I affects ubiquinone binding as revealed by modeling in Escherichia coli NDH-1.

T. Nyström, K. Majamaa, I. Hassinen, 2012, Biochimica et biophysica acta.

Metabolic and hormonal changes during intravenous infusion of ethanol, acetaldehyde and acetate in normal and adrenalectomized rats.

I. Hassinen, V. P. Jauhonen, 1978, Archives of biochemistry and biophysics.

Superoxide production during ischemia-reperfusion in the perfused rat heart: a comparison of two methods of measurement.

U. Bergmann, I. Hassinen, K. Ylitalo, 2012, Journal of molecular and cellular cardiology.

Influence of calcium-induced workload transitions and fatty acid supply on myocardial substrate selection.

I. Hassinen, P. Ingman, M. Ylihautala, 2005, Metabolism: clinical and experimental.

Placental Mitochondrial DNA and Respiratory Chain Enzymes in the Etiology of Preeclampsia

I. Hassinen, R. Sormunen, A. Remes, 1998, Obstetrics and gynecology.

Transmural distribution of left ventricular glucose uptake in spontaneously hypertensive rats during rest and exercise.

T. Takala, I. Hassinen, H. Ruskoaho, 1989, Acta physiologica Scandinavica.

Cyclic AMP-linked mechanisms in ethanol-induced derangements of metabolism in rat liver and adipose tissue.

M. Savolainen, I. Hassinen, V. P. Jauhonen, 1975, Biochemical pharmacology.

Contribution of endothelium and cardiomyocytes to hypoxia-induced adenosine release.

I. Hassinen, K. Peuhkurinen, M. Raatikainen, 1994, Journal of molecular and cellular cardiology.

Regulation of cellular respiration in myoglobin-deficient mouse heart

I. Hassinen, J. Schrader, A. Gödecke, 2004, Molecular and Cellular Biochemistry.

Individuals with mutations in XPNPEP3, which encodes a mitochondrial protein, develop a nephronophthisis-like nephropathy (Journal of Clinical Investigation (2010) 120, 3 (791-802) DOI: 10.1172/JCI40076)

Bethan E. Hoskins, D. Seelow, H. Prokisch, 2010 .

A mutation in mitochondrial DNA-encoded cytochrome c oxidase II gene in a child with Alpers-Huttenlocher-like disease.

S. Finnilä, K. Majamaa, I. Hassinen, 2003, Pediatrics.

Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy

K. Alitalo, M. Orešič, I. Hassinen, 2008, Circulation research.

SPECIFIC AND NONSPECIFIC EFFECTS OF LONG-TERM ADMINISTRATION OF ETHANOL ON HEPATIC FATTY ACID SYNTHESIS AND ITS ROLE IN THE DEVELOPMENT OF FATTY LIVER

M. Savolainen, I. Hassinen, K. Hiltunen, 1977 .

On the induction of tyrosine aminotransferase in rat liver by α-methyl-p-tyrosine

I. Hassinen, J. Pispa, J. Ohisalo, 1974 .

Effect of a transaminase inhibitor on the transport of cytosolic reducing equivalents into mitochondria.

I. Hassinen, R. Ylikahri, M. Kähönen, 1971, Biochemical and biophysical research communications.

Levels of cytochromes in heart, liver, kidney and brain in the developing rat

I. Hassinen, P. Mäenpää, M. Hallman, 1972, Experientia.

Effect of fructose on cellular respiration in perfused rat liver.

I. Hassinen, R. Ylikahri, M. Kähönen, 2009, Acta medica Scandinavica. Supplementum.

A pair of membrane-embedded acidic residues in the NuoK subunit of Escherichia coli NDH-1, a counterpart of the ND4L subunit of the mitochondrial complex I, are required for high ubiquinone reductase activity.

M. Finel, I. Hassinen, M. Kervinen, 2004, Biochemistry.