J. Lear

发表

Computational de novo design, and characterization of an A(2)B(2) diiron protein.

C. M. Summa, W. DeGrado, M. Rosenblatt, 2002, Journal of molecular biology.

Factor XI Homodimer Structure Is Essential for Normal Proteolytic Activation by Factor XIIa, Thrombin, and Factor XIa*

T. Walz, C. Yip, J. Lear, 2008, Journal of Biological Chemistry.

Supporting Online Material for Computational Design of Peptides That Target Transmembrane Helices

Gregory A Caputo, Bryan W Berger, W. DeGrado, 2007 .

Morphological changes and fusogenic activity of influenza virus hemagglutinin.

J. Lear, P. Axelsen, T. Shangguan, 1998, Biophysical journal.

Asparagine-mediated self-association of a model transmembrane helix

William F. DeGrado, James D. Lear, W. DeGrado, 2000, Nature Structural Biology.

Experimental and computational evaluation of forces directing the association of transmembrane helices.

William F. DeGrado, James D. Lear, Daniel W. Kulp, 2009, Journal of the American Chemical Society.

Relationship between side chain structure and 14-helix stability of beta3-peptides in water.

Joshua A. Kritzer, W. L. Jorgensen, J. Tirado-Rives, 2005, Journal of the American Chemical Society.

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus.

R. Lamb, W. DeGrado, L. Pinto, 2008, Structure.

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

R. Lamb, W. DeGrado, L. Pinto, 2009, Proceedings of the National Academy of Sciences.

Helical β-Peptide Inhibitors of the p53-hDM2 Interaction

Joshua A. Kritzer, A. Schepartz, J. Lear, 2004 .

Protein design, a minimalist approach.

W. DeGrado, J. Lear, Z. Wasserman, 1989, Science.

Multiple oligomeric states regulate the DNA binding of helix-loop-helix peptides.

W. DeGrado, R. Fairman, J. Lear, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Characterization of the monomeric form of the transmembrane and cytoplasmic domains of the integrin beta 3 subunit by NMR spectroscopy.

A. Wand, W. DeGrado, J. Lear, 2002, Biochemistry.

Direct analysis of protein sedimentation equilibrium in detergent solutions without density matching.

J. Lear, Jennifer R. Calhoun, Dror Noy, 2003, Analytical biochemistry.

Total chemical synthesis of the integral membrane protein influenza A virus M2: role of its C-terminal domain in tetramer assembly.

G. Kochendoerfer, W. DeGrado, S. Kent, 1999, Biochemistry.

Design of a functional membrane protein by engineering a heme-binding site in glycophorin A.

J. Lear, G. Ghirlanda, Jeanine M. Cordova, 2007, Journal of the American Chemical Society.

Proton conduction through the M2 protein of the influenza A virus; a quantitative, mechanistic analysis of experimental data

J. Lear, J. D. Lear, 2003, FEBS letters.

The role of protonation and metal chelation preferences in defining the properties of mercury-binding coiled coils.

K. Sharp, W. DeGrado, J. Lear, 1998, Journal of molecular biology.

Membrane fusion activity of the influenza virus hemagglutinin: interaction of HA2 N-terminal peptides with phospholipid vesicles.

W. DeGrado, J. Lear, J. Wilschut, 1991, Biochemistry.

Seismostratigraphy and Thermal Structure of Earth ’ s Core-Mantle Boundary Region

W. DeGrado, J. Lear, B. Berger, 2007 .

Polyglutamine toxicity: a new idea for a tough problem.

J. Lear, 2000, Biophysical journal.

Synthetic peptides as models for ion channel proteins

W. DeGrado, J. Lear, K. Åkerfeldt, 1993 .

De novo design of a pentameric coiled-coil: decoding the motif for tetramer versus pentamer formation in water-soluble phospholamban.

W. DeGrado, J. Lear, A. Slovic, 2005, The journal of peptide research : official journal of the American Peptide Society.

Polar side chains drive the association of model transmembrane peptides.

W. DeGrado, J. Lear, H. Gratkowski, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The Interplay of Thermodynamic Stability, Functional Tuning, and Drug Resistance in the Evolution of the M2 Proton Channel From the Influenza A Virus

R. Lamb, W. DeGrado, L. Pinto, 2008 .

Membrane Fusion Activity of Influenza Virus and Reconstituted Viral Envelopes (Virosomes)

W. DeGrado, J. Lear, J. Dijkstra, 1991 .

Mechanistic insights from functional characterization of an unnatural His37 mutant of the influenza A/M2 protein.

W. DeGrado, L. Pinto, J. Lear, 2014, Biochimica et biophysica acta.

A pH-dependent conformational ensemble mediates proton transport through the influenza A/M2 protein.

R. Lamb, W. DeGrado, L. Pinto, 2010, Biochemistry.

Characterization of a membrane protein folding motif, the Ser zipper, using designed peptides.

W. DeGrado, Benjamin North, J. Lear, 2006, Journal of molecular biology.

Electrostatic Effects on Ion Selectivity and Rectification in Designed Ion Channel Peptides

P. Kienker, W. DeGrado, J. Lear, 1997 .

An integral representation for the modified Bessel function of the third kind, computable for large, imaginary order

J. Lear, J. Sturm, 1967 .

A Designed Buried Salt Bridge in a Heterodimeric Coiled Coil

William F. DeGrado, James D. Lear, Joel P. Schneider, 1997 .

Synthetic peptides as models for ion channel proteins

Zelda R. Wasserman, William F. DeGrado, W. DeGrado, 1993 .

Relationship between salt-bridge identity and 14-helix stability of beta3-peptides in aqueous buffer.

A. Schepartz, J. Lear, D. Guarracino, 2006, Organic letters.

How do helix–helix interactions help determine the folds of membrane proteins? Perspectives from the study of homo‐oligomeric helical bundles

W. DeGrado, J. Lear, H. Gratkowski, 2003, Protein science : a publication of the Protein Society.

Computational design of a self-assembling β-peptide oligomer.

Scott J. Shandler, Ivan V Korendovych, W. DeGrado, 2010, Organic letters.

Structure/Function Aspects of Actinobacillus actinomycetemcomitans Leukotoxin.

J. Lear, E. Lally, I. Kieba, 1996, The Journal of Periodontology.

pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virus.

W. DeGrado, J. Lear, D. Salom, 2000, Biochemistry.

Synthetic amphiphilic peptide models for protein ion channels.

W. DeGrado, J. Lear, Z. Wasserman, 1988, Science.

A helical-dipole model describes the single-channel current rectification of an uncharged peptide ion channel.

P. Kienker, W. DeGrado, J. Lear, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Effect of divalent cations on the structure of the antibiotic daptomycin

W. Scott, R. Hancock, J. Lear, 2008, European Biophysics Journal.

A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity.

R. Lamb, W. DeGrado, L. Pinto, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Design and synthesis of multi-haem proteins

Christopher C. Moser, P. Leslie Dutton, A. Joshua Wand, 1994, Nature.

Design of a heme-binding four-helix bundle

P. Leslie Dutton, William F. DeGrado, James D. Lear, 1994 .

Activation of Integrin αIIbß3 by Modulation of Transmembrane Helix Associations

Renhao Li, William F. DeGrado, James D. Lear, 2003, Science.

Activation of platelet alphaIIbbeta3 by an exogenous peptide corresponding to the transmembrane domain of alphaIIb.

W. DeGrado, J. Weisel, J. Lear, 2006, The Journal of biological chemistry.

Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization.

J. Lear, M. Pantoliano, D. E. Van Dyk, 1994, Biochemistry.

Mechanism for Proton Conduction of the M2 Ion Channel of Influenza A Virus*

R. Lamb, J. Lear, A. Pekosz, 2000, The Journal of Biological Chemistry.

Cu(II) Inhibition of the Proton Translocation Machinery of the Influenza A Virus M2 Protein*

R. Lamb, W. DeGrado, J. Lear, 1999, The Journal of Biological Chemistry.

Structural basis for ligand-mediated mouse GITR activation

J. Lear, Xiaomin Song, K. Furuuchi, 2008, Proceedings of the National Academy of Sciences.

Polar networks control oligomeric assembly in membranes.

W. DeGrado, Vikas Nanda, J. Lear, 2006, Journal of the American Chemical Society.

Activation of integrin alphaIIbbeta3 by modulation of transmembrane helix associations.

Renhao Li, W. DeGrado, J. Weisel, 2003, Science.

In vivo function and membrane binding properties are correlated for Escherichia coli lamB signal peptides.

L. Gierasch, W. DeGrado, A. Zlotnick, 1985, Science.

Characterization of Actinobacillus actinomycetemcomitans leukotoxin pore formation in HL60 cells.

J. Lear, E. Lally, J. Tanaka, 1998, Biochimica et biophysica acta.

Exploration of the structural features defining the conduction properties of a synthetic ion channel.

K. Sharp, M. Klein, W. DeGrado, 1999, Biophysical journal.

From synthetic coiled coils to functional proteins: automated design of a receptor for the calmodulin-binding domain of calcineurin.

W. DeGrado, J. Lear, G. Ghirlanda, 1998, Journal of molecular biology.

Use of thiol-disulfide equilibria to measure the energetics of assembly of transmembrane helices in phospholipid bilayers

William F. DeGrado, James D. Lear, W. DeGrado, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Permeation through an open channel: Poisson-Nernst-Planck theory of a synthetic ionic channel.

J. Lear, B. Eisenberg, D. Chen, 1997, Biophysical journal.

Association of a model transmembrane peptide containing gly in a heptad sequence motif.

W. DeGrado, Vikas Nanda, J. Lear, 2004, Biophysical journal.

Determination of membrane protein stability via thermodynamic coupling of folding to thiol–disulfide interchange

W. DeGrado, J. Lear, Lidia Cristian, 2003, Protein science : a publication of the Protein Society.

Position-dependence of stabilizing polar interactions of asparagine in transmembrane helical bundles.

Jie Liang, Jie Liang, W. DeGrado, 2003, Biochemistry.

Fluorescence studies of the secondary structure and orientation of a model ion channel peptide in phospholipid vesicles.

W. DeGrado, J. Lear, W F DeGrado, 1992, Biochemistry.

Tetraphilin : a four-helix proton channel built on a tetraphenylporphyrin framework

John T. Groves, William F. DeGrado, W. DeGrado, 1992 .

Oligomerization of fusogenic peptides promotes membrane fusion by enhancing membrane destabilization.

W. DeGrado, D. Hammer, J. Lear, 2004, Biophysical journal.

Induction of peptide conformation at apolar water interfaces. 1. A study with model peptides of defined hydrophobic periodicity

William F. DeGrado, James D. Lear, W. DeGrado, 1985 .

A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit.

B. Cooperman, J. Lear, C. Scott, 2002, Biochemistry.

Dynein and Dynactin Leverage Their Bivalent Character to Form a High-Affinity Interaction

M. Poenie, J. Cooper, J. Lear, 2013, PloS one.

A quantitative model for allosteric control of purine reduction by murine ribonucleotide reductase.

B. Cooperman, J. Lear, C. Scott, 2001, Biochemistry.

Use of Synthetic Peptides for the Study of Membrane Protein Structure

W. DeGrado, J. Lear, Z. Wasserman, 1994 .

Biochemical and Structural Characterization of the Pak1-LC8 Interaction*

J. Lear, U. Rodeck, Shangjin Sun, 2008, Journal of Biological Chemistry.

Membrane binding and conformational properties of peptides representing the NH2 terminus of influenza HA-2.

W. DeGrado, J. Lear, J. D. Lear, 1987, The Journal of biological chemistry.

Computational design of a water‐soluble analog of phospholamban

W. DeGrado, J. Lear, William F DeGrado, 2003, Protein science : a publication of the Protein Society.

Recent developments in polymer characterisation by dynamic mechanical analysis

J. Lear, J. Leckenby, P. Gill, 1984 .

Using alpha-helical coiled-coils to design nanostructured metalloporphyrin arrays.

Alessandro Senes, Vikas Nanda, Jeffery G Saven, 2008, Journal of the American Chemical Society.

Synergistic interactions between aqueous and membrane domains of a designed protein determine its fold and stability.

W. DeGrado, Vikas Nanda, J. Lear, 2005, Journal of molecular biology.

Design of amphiphilic protein maquettes: controlling assembly, membrane insertion, and cofactor interactions.

P. Dutton, J. Lear, J. Strzalka, 2005, Biochemistry.

Conformationally constrained α‐helical peptide models for protein ion channels

W. DeGrado, J. Lear, 1990 .

Phospholipid interactions of synthetic peptides representing the N-terminus of HIV gp41.

W. DeGrado, J. Lear, M. Rafalski, 1990, Biochemistry.

A push-pull mechanism for regulating integrin function.

W. DeGrado, Vikas Nanda, J. Lear, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Charge selectivity of the designed uncharged peptide ion channel Ac-(LSSLLSL)3-CONH2.

P. Kienker, J. Lear, P K Kienker, 1995, Biophysical journal.

Activation of Platelet αIIbβ3 by an Exogenous Peptide Corresponding to the Transmembrane Domain of αIIb*>

W. DeGrado, J. Weisel, J. Lear, 2006, Journal of Biological Chemistry.

Inhaled anesthetic modulation of amyloid beta(1-40) assembly and growth.

R. Eckenhoff, J. Lear, A. Carnini, 2007, Current Alzheimer research.

Computational design of water-soluble analogues of the potassium channel KcsA

Jeffery G. Saven, Hidetoshi Kono, William F. DeGrado, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Oligomerization of the integrin αIIbβ3: Roles of the transmembrane and cytoplasmic domains

Renhao Li, A. Joshua Wand, William F. DeGrado, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Conformational studies of Actinobacillus actinomycetemcomitans leukotoxin: partial denaturation enhances toxicity.

J. Lear, E. Lally, J. Tanaka, 2000, Biochimica et biophysica acta.

De novo design and molecular assembly of a transmembrane diporphyrin-binding protein complex.

Alessandro Senes, Ivan V Korendovych, W. DeGrado, 2010, Journal of the American Chemical Society.

A new data analysis method to determine binding constants of small molecules to proteins using equilibrium analytical ultracentrifugation with absorption optics.

J. Lear, J D Lear, M Arkin, 2001, Analytical biochemistry.

Sequence determinants of a transmembrane proton channel: an inverse relationship between stability and function.

Vikas Nanda, W. DeGrado, Vikas Nanda, 2005, Journal of molecular biology.

Sequence determinants of the energetics of folding of a transmembrane four-helix-bundle protein

W. DeGrado, J. Lear, K. P. Howard, 2002, Proceedings of the National Academy of Sciences of the United States of America.

A hierarchic approach to the design of hexameric helical barrels.

D. Eisenberg, W. DeGrado, J. Lear, 2002, Journal of molecular biology.

Proton and metal ion‐dependent assembly of a model diiron protein

W. DeGrado, J. Lear, J. Kaplan, 2001, Protein science : a publication of the Protein Society.

Dimerization of the Transmembrane Domain of Integrin αIIb Subunit in Cell Membranes*

Vikas Nanda, Renhao Li, W. DeGrado, 2004, Journal of Biological Chemistry.

Inhaled Anesthetic Modulation of Amyloid β 1-40 Assembly and Growth

R. Eckenhoff, J. Lear, A. Carnini, 2007 .

Computational de novo design, and characterization of an A(2)B(2) diiron protein.

Christopher M. Summa, W. DeGrado, M. Rosenblatt, 2002, Journal of molecular biology.

Volatile anesthetic modulation of oligomerization equilibria in a hexameric model peptide

R. Eckenhoff, W. DeGrado, J. Johansson, 2004, FEBS letters.