D. Morikis

发表

De novo peptide design with C3a receptor agonist and antagonist activities: theoretical predictions and experimental validation.

H. K. Fung, C. Floudas, P. Monk, 2012, Journal of medicinal chemistry.

Toward full-sequence de novo protein design with flexible templates for human beta-defensin-2.

Martin S. Taylor, H. K. Fung, C. Floudas, 2008, Biophysical journal.

New compstatin variants through two de novo protein design frameworks.

H. K. Fung, C. Floudas, H. Fung, 2010, Biophysical journal.

Molecular thermodynamics for charged biomacromolecules

D. Morikis, Jianzhong Wu, 2006 .

Electrostatic Clustering and Free Energy Calculations Provide a Foundation for Protein Design and Optimization

Dimitrios Morikis, Chris A. Kieslich, C. Kieslich, 2010, Annals of Biomedical Engineering.

A multifaceted study of stigma/style cysteine-rich adhesin (SCA)-like Arabidopsis lipid transfer proteins (LTPs) suggests diversified roles for these LTPs in plant growth and reproduction

C. Kieslich, D. Morikis, E. Lord, 2010, Journal of experimental botany.

Physical methods for structure, dynamics and binding in immunological research.

Dimitrios Morikis, John D Lambris, J. Lambris, 2004, Trends in immunology.

A predictive model for HIV type 1 coreceptor selectivity.

C. Kieslich, D. Morikis, A. López de Victoria, 2013, AIDS research and human retroviruses.

Novel compstatin family peptides inhibit complement activation by drusen-like deposits in human retinal pigmented epithelial cell cultures.

Christodoulos A Floudas, Phanourios Tamamis, Chris A Kieslich, 2013, Experimental eye research.

Detection of Side Chain Rearrangements Mediating the Motions of Transmembrane Helices in Molecular Dynamics Simulations of G Protein-Coupled Receptors

D. Morikis, Z. Gaieb, Zied Gaieb, 2017, Computational and structural biotechnology journal.

A computational model for the evaluation of complement system regulation under homeostasis, disease, and drug intervention

D. Morikis, Nehemiah T. Zewde, 2017, bioRxiv.

A Computational Model for the Evaluation of Complement System Regulation under Homeostasis, Disease, and Drug Intervention

D. Morikis, Nehemiah T. Zewde, 2017, bioRxiv.

Resonance raman investigations of site-directed mutants of myoglobin: effects of distal histidine replacement.

S. Sligar, D. Morikis, P. Champion, 1989, Biochemistry.

Conformational interconversion in protein crystals.

D. Morikis, L. Zhu, P. Champion, 1992, Journal of molecular biology.

Insights into the mechanism of C5aR inhibition by PMX53 via implicit solvent molecular dynamics simulations and docking

G. Nikiforovich, C. Kieslich, D. Morikis, 2014, BMC biophysics.

Complement Inhibition by Staphylococcus aureus: Electrostatics of C3d–EfbC and C3d–Ehp Association

C. Kieslich, D. Morikis, R. D. Gorham, 2012 .

Electrostatic Similarity Determination Using Multiresolution Analysis

D. Gunopulos, C. Kieslich, D. Morikis, 2011, Molecular informatics.

Peptide redesign for inhibition of the complement system: Targeting age-related macular degeneration

Reed E S Harrison, L. V. Johnson, D. Morikis, 2016, Molecular vision.

The effect of electrostatics on factor H function and related pathologies.

C. Kieslich, D. Morikis, A. López de Victoria, 2011, Journal of molecular graphics & modelling.

Engineering pre-SUMO4 as efficient substrate of SENP2.

C. Kieslich, D. Morikis, Jiayu Liao, 2014, Protein engineering, design & selection : PEDS.

Solvation effects in calculated electrostatic association free energies for the C3d-CR2 complex and comparison with experimental data.

C. Kieslich, D. Morikis, Alexander S Cheung, 2010, Biopolymers.

Automated computational framework for the analysis of electrostatic similarities of proteins

D. Gunopulos, C. Kieslich, D. Morikis, 2011, Biotechnology progress.

Electrostatic Interactions between Complement Regulator CD46(SCR1-2) and Adenovirus Ad11/Ad21 Fiber Protein Knob

D. Morikis, Z. Gaieb, R. D. Gorham, 2015, Molecular biology international.

Characterization of the interaction between peptides derived from the gp120/V3 domain of HIV-1 and the amino terminal of the chemokine receptor CCR5 by NMR spectroscopy and light scattering

D. Morikis, A. Rizos, G. Spyroulias, 2006 .

Immunophysical Evaluation of the Initiating Step in the Formation of the Membrane Attack Complex

D. Morikis, Nehemiah T. Zewde, Rohith R. Mohan, 2018, Front. Phys..

De Novo Protein Design " An Interplay of Global Optimization , Mixed-Integer Optimization and Experiments

C. Floudas, J. L. Klepeis, J. Lambris, 2004 .

Molecular Mechanisms of Macular Degeneration Associated with the Complement Factor H Y402H Mutation.

Reed E S Harrison, D. Morikis, Reed E. S. Harrison, 2019, Biophysical journal.

Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.

Reed E S Harrison, Jen‐Shin Song, D. Morikis, 2019, Cell chemical biology.

Complement Inhibitor Compstatin Relationship, and Biotransformation of the Binding Kinetics, Structure-Activity

W. T. Moore, John D Lambris, Spruce, 2000 .

New Compstatin Peptides Containing N-Terminal Extensions and Non-Natural Amino Acids Exhibit Potent Complement Inhibition and Improved Solubility Characteristics

Christodoulos A. Floudas, George A. Khoury, Phanourios Tamamis, 2014, Journal of medicinal chemistry.

A New Generation of Potent Complement Inhibitors of the Compstatin Family

C. Floudas, Meghan L. Bellows-Peterson, D. Morikis, 2011, Chemical biology & drug design.

Resonance Raman studies of iron spin and axial coordination in distal pocket mutants of ferric myoglobin.

S. Sligar, D. Morikis, P. Champion, 1990, The Journal of biological chemistry.

Complement Inhibition by Staphylococcus aureus: Electrostatics of C3d–EfbC and C3d–Ehp Association

C. Kieslich, D. Morikis, R. Gorham, 2011, Cellular and Molecular Bioengineering.

Electrostatic Modeling Predicts the Activities of Orthopoxvirus Complement Control Proteins1

Dimitrios Morikis, John D. Lambris, Madan Katragadda, 2005, The Journal of Immunology.

Review from Atoms to Systems: a Cross-disciplinary Approach to Complement-mediated Functions

John D Lambris, J. Lambris, D. Morikis, 2022 .

Conformational interconversion in compstatin probed with molecular dynamics simulations

Dimitrios Morikis, John D Lambris, Buddhadeb Mallik, 2003, Proteins.

Studies of Structure-Activity Relations of Complement Inhibitor Compstatin 1

Dimitrios Morikis, John D Lambris, M. Roy, 2003 .

Compstatin, a peptide inhibitor of complement, exhibits species-specific binding to complement component C3.

Dimitrios Morikis, John D Lambris, J. Lambris, 2003, Molecular immunology.

Complement Inhibitor Compstatin Studies of Structure-Activity Relations of

D. John, M. Roy, D. Morikis, 2003 .

Binding Kinetics, Structure-Activity Relationship, and Biotransformation of the Complement Inhibitor Compstatin1

Dimitrios Morikis, John D. Lambris, W. T. Moore, 2000, The Journal of Immunology.

Solution structure of Compstatin, a potent complement inhibitor

Dimitrios Morikis, John D Lambris, N. Assa‐Munt, 1998, Protein science : a publication of the Protein Society.

Complement Inhibitors Targeting C3, C4, and C5

John D Lambris, J. Lambris, D. Morikis, 2000 .

Alteration of heme axial ligands by site-directed mutagenesis: a cytochrome becomes a catalytic demethylase

Dimitrios Morikis, J. Timothy Sage, Stephen G. Sligar, 1987 .

Structure of the Anaphylatoxins C3a and C5a

John D Lambris, J. Lambris, D. Morikis, 2005 .

Spectroscopic studies of myoglobin at low pH: heme structure and ligation.

D. Morikis, P. Champion, D Morikis, 1991, Biochemistry.

The iron-histidine mode of myoglobin revisited: resonance Raman studies of isotopically labeled Escherichia coli-expressed myoglobin

A. V. Wells, S. Sligar, M. Chiu, 1991 .

Resonance Raman studies of oriented chromophores: Metmyoglobin single crystals

D. Morikis, P. Champion, J. Sage, 1989 .

Factor H-Inspired Design of Peptide Biomarkers of the Complement C3d Protein.

D. Morikis, G. Palermo, Rohaine V. Hsu, 2020, ACS medicinal chemistry letters.

Design of a modified mouse protein with ligand binding properties of its human analog by molecular dynamics simulations: The case of C3 inhibition by compstatin

Phanourios Tamamis, Dimitrios Morikis, Georgios Archontis, 2011, Proteins.

Systems Biology Modeling of the Complement System Under Immune Susceptible Pathogens

D. Morikis, G. Palermo, Rohaine V. Hsu, 2021, Frontiers in Physics.

Susan S. Taylor, M. Roy, P. Jennings, 2003, Journal of molecular biology.

Computational studies of CXCR1, the receptor of IL-8/CXCL8, using molecular dynamics and electrostatics.

N. Huynh, Li Zhang, D. Morikis, 2008, Biopolymers.

A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes

J. Scott, M. Roy, P. Jennings, 2001, The EMBO journal.

Endosidin2 targets conserved exocyst complex subunit EXO70 to inhibit exocytosis

Zhenbiao Yang, Wei Guo, N. Raikhel, 2015, Proceedings of the National Academy of Sciences.

A Gain-of-Function Mutation of Arabidopsis Lipid Transfer Protein 5 Disturbs Pollen Tube Tip Growth and Fertilization[C][W]

C. Kieslich, D. Morikis, E. Lord, 2009, The Plant Cell Online.

Resonance Raman studies of myoglobin single crystals

D. Morikis, A. Rizos, P. Champion, 1988 .

The molecular basis for protein kinase A anchoring revealed by solution NMR

John D. Scott, M. Roy, P. Jennings, 1998, Nature Structural Biology.

Quantitative Modeling of the Alternative Pathway of the Complement System

Dimitrios Morikis, D. Morikis, Nehemiah Zewde, 2016, PloS one.

A Predictive Model for HIV-1 Co-receptor Selectivity

C. Kieslich, D. Morikis, G. González-Rivera, 2013 .

Contribution of Specific Amino Acid Changes in Penicillin Binding Protein 1 to Amoxicillin Resistance in Clinical Helicobacter pylori isolates

D. Morikis, N. Schiller, N. Qureshi, 2010, Antimicrobial Agents and Chemotherapy.

Clustering of HIV-1 Subtypes Based on gp120 V3 Loop electrostatic properties

Chris A Kieslich, Dimitrios Morikis, C. Kieslich, 2012, BMC biophysics.

Adaptation of inorganic quantum dots for stable molecular beacons

M. Ozkan, D. Morikis, J. Kim, 2004 .

Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways

Amanda N. Saavedra, Harbani K. Malik-Chaudhry, D. Morikis, 2018, Scientific Reports.

The Building Blocks of the Complement System

J. Lambris, D. Morikis, 2005 .

Alteration of sperm whale myoglobin heme axial ligation by site-directed mutagenesis.

S. Martinis, S. Sligar, D. Morikis, 1990, Biochemistry.

Role of Electrostatic Hotspots in the Selectivity of Complement Control Proteins Toward Human and Bovine Complement Inhibition

C. Kieslich, D. Morikis, P. Arantes, 2021, Frontiers in Molecular Biosciences.

Integrated computational and experimental approach for lead optimization and design of compstatin variants with improved activity.

Christodoulos A Floudas, Dimitrios Morikis, John D Lambris, 2003, Journal of the American Chemical Society.

Discovery of functionally selective C5aR2 ligands: novel modulators of C5a signalling

C. Floudas, P. Monk, D. Morikis, 2016, Immunology and cell biology.

Overcoming the Key Challenges in De Novo Protein Design: Enhancing Computational Efficiency and Incorporating True Backbone Flexibility

Li Zhang, Christodoulos A. Floudas, Martin S. Taylor, 2008 .

Structure, Dynamics, Activity, and Function of Compstatin and Design of More Potent Analogues

J. Lambris, D. Morikis, 2005 .

Design of peptide analogues with improved activity using a novel de novo protein design approach

John L. Klepeis, Christodoulos A. Floudas, Dimitrios Morikis, 2004 .

Predicting peptide structures using NMR data and deterministic global optimization

John L. Klepeis, Christodoulos A. Floudas, Dimitrios Morikis, 1999, J. Comput. Chem..

Structure-Based Integrative Computational and Experimental Approach for the Optimization of Drug Design

Christodoulos A. Floudas, Dimitrios Morikis, John D. Lambris, 2005, International Conference on Computational Science.

The pH dependence of stability of the activation helix and the catalytic site of GART.

A. Elcock, J. Mccammon, P. Jennings, 2003, Biophysical chemistry.

Proton transfer dynamics of GART: The pH‐dependent catalytic mechanism examined by electrostatic calculations

A. Elcock, J. Mccammon, P. Jennings, 2001, Protein science : a publication of the Protein Society.

Native‐state conformational dynamics of GART: A regulatory pH‐dependent coil–helix transition examined by electrostatic calculations

A. Elcock, J. Mccammon, P. Jennings, 2001, Protein science : a publication of the Protein Society.

Energetic evaluation of binding modes in the C3d and Factor H (CCP 19‐20) complex

D. Morikis, R. Gorham, Reed E S Harrison, 2015, Protein science : a publication of the Protein Society.

Molecular analysis of the interaction between staphylococcal virulence factor Sbi-IV and complement C3d.

D. Morikis, R. Gorham, Wilson Rodríguez, 2014, Biophysical journal.

The Electrostatic Nature of C3d-Complement Receptor 2 Association1

John D Lambris, J. Lambris, D. Morikis, 2004, The Journal of Immunology.

Immunophysical exploration of C3d-CR2(CCP1-2) interaction using molecular dynamics and electrostatics.

Li Zhang, D. Morikis, B. Mallik, 2007, Journal of molecular biology.

Immunophysical properties and prediction of activities for vaccinia virus complement control protein and smallpox inhibitor of complement enzymes using molecular dynamics and electrostatics.

Li Zhang, D. Morikis, 2006, Biophysical journal.

Hybrid flagellin as a T cell independent vaccine scaffold

D. Morikis, D. Lo, Veronica Gusti, 2015, BMC Biotechnology.

Ionic tethering contributes to the conformational stability and function of complement C3b

D. Morikis, S. Rodríguez de Córdoba, O. Llorca, 2017, Molecular immunology.

The Structural Basis of Compstatin Activity Examined by Structure-Function-based Design of Peptide Analogs and NMR* 210

Dimitrios Morikis, John D. Lambris, Patricia A. Jennings, 2002, The Journal of Biological Chemistry.

Molecular Dynamics in Drug Design: New Generations of Compstatin Analogs

Christodoulos A Floudas, Phanourios Tamamis, Dimitrios Morikis, 2012, Chemical biology & drug design.

Influence of Electrostatics on the Complement Regulatory Functions of Kaposica, the Complement Inhibitor of Kaposi’s Sarcoma-Associated Herpesvirus

C. Kieslich, D. Morikis, A. Sahu, 2010, The Journal of Immunology.

Complement

John D Lambris, J. Lambris, D. Morikis, 2003, Immunologic research.

SPARC coordinates extracellular matrix remodeling and efficient recruitment to and migration of antigen-specific T cells in the brain following infection

A. Obenaus, M. Carson, D. Morikis, 2021, Scientific Reports.

NMR evidence for multiple conformations in a highly helical model peptide.

P. Wright, R. Brüschweiler, D. Morikis, 1993, Biochemistry.

Derivation of ligands for the complement C3a receptor from the C-terminus of C5a

Christodoulos A Floudas, Chris A Kieslich, Dimitrios Morikis, 2014, European journal of pharmacology.

Immunopharmacology and in fl ammation Derivation of ligands for the complement C 3 a receptor from the C-terminus of C 5 a

C. Floudas, P. Monk, J. Smadbeck, 2014 .

Structural study of Ac‐Phe‐[Orn‐Pro‐dCha‐Trp‐Arg], a potent C5a receptor antagonist, by NMR

Li Zhang, D. Morikis, B. Mallik, 2008, Biopolymers.

A Selective Reference to Current Research and Practice

John D Lambris, J. Lambris, D. Morikis, 2003 .

M13 bacteriophage spheroids as scaffolds for directed synthesis of spiky gold nanostructures.

D. Morikis, T. Ngo-Duc, J. Plank, 2018, Nanoscale.

Two SCA (Stigma/Style Cysteine-rich Adhesin) Isoforms Show Structural Differences That Correlate with Their Levels of in Vitro Pollen Tube Adhesion Activity*

Li Zhang, D. Morikis, J. Mollet, 2007, Journal of Biological Chemistry.

Molecular Mechanism of Biased Ligand Conformational Changes in CC Chemokine Receptor 7

Dimitrios Morikis, Zied Gaieb, David D. Lo, 2016, J. Chem. Inf. Model..

Virtual Screening of Chemical Compounds for Discovery of Complement C3 Ligands

Asuka A. Orr, C. Kieslich, D. Morikis, 2018, ACS omega.

Viral regulators of complement activation: structure, function and evolution.

D. Morikis, A. Sahu, Hina Ojha, 2014, Molecular immunology.

Thermodynamic Studies on the Interaction of the Third Complement Component and Its Inhibitor, Compstatin*

Dimitrios Morikis, Madan Katragadda, John D Lambris, 2004, Journal of Biological Chemistry.

Crosslinked flagella as a stabilized vaccine adjuvant scaffold

D. Morikis, D. Lo, Rohith R. Mohan, 2019, BMC Biotechnology.

Structural Biology of the Complement System

J. Lambris, D. Morikis, 2005 .

The Two Sides of Complement C3d: Evolution of Electrostatics in a Link between Innate and Adaptive Immunity

Dimitrios Morikis, Chris A. Kieslich, C. Kieslich, 2012, PLoS Comput. Biol..

Receptor 2 Association The Electrostatic Nature of C 3 d-Complement

John D Lambris, J. Lambris, D. Morikis, 2004 .

The Electrostatic Nature of C 3 d-Complement Receptor 2 Association 1

John D Lambris, J. Lambris, D. Morikis, 2004 .

Design and NMR characterization of active analogues of compstatin containing non-natural amino acids.

Dimitrios Morikis, Madan Katragadda, John D Lambris, 2005, Journal of medicinal chemistry.

Synthetic small-molecule complement inhibitors.

John D Lambris, J. Lambris, D. Morikis, 2004, Current opinion in investigational drugs.

A theoretical view of the C3d:CR2 binding controversy.

D. Morikis, Rohith R. Mohan, R. Gorham, 2015, Molecular immunology.

Improvement of the anti-C3 activity of compstatin using rational and combinatorial approaches.

John D Lambris, J L Klepeis, C A Floudas, 2004, Biochemical Society transactions.

Structural aspects and design of low-molecular-mass complement inhibitors.

John D Lambris, J. Lambris, D. Morikis, 2001, Biochemical Society transactions.

Hybrid Inorganic-Organic Molecular Beacons

Jared P. Stephens, M. Ozkan, D. Morikis, 2004 .

An immunophysical study of the complement system: Examples for the pH dependence of protein binding and stability

Li Zhang, D. Morikis, 2006 .

Hydrogen exchange in the carbon monoxide complex of soybean leghemoglobin.

P. Wright, D. Morikis, 1996, European journal of biochemistry.

Electrostatic Steering Accelerates C3d:CR2 Association

G. Huber, D. Morikis, Rohith R. Mohan, 2016, The journal of physical chemistry. B.

NMR evidence of charge‐dependent interaction between various PND V3 and CCR5 N‐terminal peptides

D. Morikis, A. Rizos, G. Spyroulias, 2009, Biopolymers.

Electrostatic properties of the structure of the docking and dimerization domain of protein kinase A IIalpha.

John D. Scott, M. Roy, P. Jennings, 2002, European journal of biochemistry.

Species specificity of the complement inhibitor compstatin investigated by all‐atom molecular dynamics simulations

Christodoulos A Floudas, Phanourios Tamamis, Dimitrios Morikis, 2010, Proteins.

Development of a quasi-dynamic pharmacophore model for anti-complement peptide analogues.

D. Morikis, B. Mallik, 2005, Journal of the American Chemical Society.

An evaluation of Poisson-Boltzmann electrostatic free energy calculations through comparison with experimental mutagenesis data.

C. Kieslich, D. Morikis, Noriko U. Sausman, 2011, Biopolymers.

Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways

Amanda N. Saavedra, Harbani K. Malik-Chaudhry, D. Morikis, 2018, Scientific Reports.

Conformational heterogeneity in CCR7 undergoes transitions to specific states upon ligand binding.

D. Morikis, Zied Gaieb, 2017, Journal of molecular graphics & modelling.

Insights into the Structure, Correlated Motions, and Electrostatic Properties of Two HIV-1 gp120 V3 Loops

Phanourios Tamamis, Dimitrios Morikis, Chris A. Kieslich, 2012, PloS one.

From atoms to systems: a cross-disciplinary approach to complement-mediated functions.

John D Lambris, J. Lambris, D. Morikis, 2004, Molecular immunology.

Integrated computational and experimental approach for lead optimization and design of compstatin variants with improved activity.

John D Lambris, C. Floudas, J. L. Klepeis, 2003, Journal of the American Chemical Society.

Structure Calculations of Symmetric Dimers using Molecular Dynamics/Simulated Annealing and NMR Restraints: The Case of the RIIα Subunit of Protein Kinase A

P. Jennings, D. Morikis, M. G. Newlon, 2000 .

Discovery of Small Molecules for Fluorescent Detection of Complement Activation Product C3d.

Jung-Hsin Lin, Vicente Nuñez, Dimitrios Morikis, 2015, Journal of medicinal chemistry.

Conformational analysis of compstatin analogues with molecular dynamics simulations in explicit water.

John D Lambris, D. Morikis, P. Tamamis, 2007, Journal of molecular graphics & modelling.

Editorial: ImmunoPhysics and ImmunoEngineering

M. Garcia-Parajo, Michael Loran Dustin, D. Morikis, 2020, Frontiers of Physics.

De novo protein design of agonists and antagonists of C5a receptors

C. Floudas, P. Monk, J. Smadbeck, 2012 .

Resonance Raman scattering as a probe of electron-nuclear coupling: applications to heme proteins

D. Morikis, P. Champion, J. Sage, 1991 .

1H resonance assignments and secondary structure of the carbon monoxide complex of soybean leghemoglobin determined by homonuclear two-dimensional and three-dimensional NMR spectroscopy.

P. Wright, D. Morikis, C. Lepre, 1994, European journal of biochemistry.

Hydration of the partially folded peptide RN-24 studied by multidimensional NMR

P. Wright, R. Brüschweiler, D. Morikis, 1995, Journal of biomolecular NMR.

M13 bacteriophage spheroids as scaffolds for directed synthesis of spiky gold nanostructures.

D. Morikis, T. Ngo-Duc, J. Plank, 2018, Nanoscale.

Electrostatic modeling of peptides derived from the V3-loop of HIV-1 gp120: implications of the interaction with chemokine receptor CCR5.

D. Spandidos, D. Morikis, A. Rizos, 2007, International journal of molecular medicine.