J. Seetharaman

发表

Computational design of a protein-based enzyme inhibitor.

D. Baker, G. Montelione, S. Fleishman, 2013, Journal of molecular biology.

Computational design of catalytic dyads and oxyanion holes for ester hydrolysis.

Liang Tong, Gaetano T Montelione, Donald Hilvert, 2012, Journal of the American Chemical Society.

Crystal structure of human retinoblastoma binding protein 9

G. Montelione, T. Acton, S. Vorobiev, 2009, Proteins.

Quantum chemical 13Cα chemical shift calculations for protein NMR structure determination, refinement, and validation

H. Scheraga, G. Montelione, L. Tong, 2008, Proceedings of the National Academy of Sciences.

Comparing Chemistry to Outcome: The Development of a Chemical Distance Metric, Coupled with Clustering and Hierarchal Visualization Applied to Macromolecular Crystallography

Gaetano T. Montelione, Joseph R. Luft, Jayaraman Seetharaman, 2014, PloS one.

The RAS-Binding Domain of Human BRAF Protein Serine/Threonine Kinase Exhibits Allosteric Conformational Changes upon Binding HRAS.

G. Montelione, T. Acton, S. Vorobiev, 2015, Structure.

A general computational approach for repeat protein design.

David Baker, Gaetano T Montelione, Keunwan Park, 2015, Journal of molecular biology.

Exploration of alternate catalytic mechanisms and optimization strategies for retroaldolase design.

David Baker, Liang Tong, Donald Hilvert, 2014, Journal of molecular biology.

Structural and biochemical characterization of the bilin lyase CpcS from Thermosynechococcus elongatus.

G. Montelione, R. Cole, T. Acton, 2013, Biochemistry.

Lemon Juice: A potential source of Angiotensin Converting Enzyme antagonism for weight loss and insulin resistance

J. Seetharaman, C. Bastie, S. Tejpal, 2018, Proceedings of the Nutrition Society.

Structure of a specialized acyl carrier protein essential for lipid A biosynthesis with very long-chain fatty acids in open and closed conformations.

G. Montelione, J. Prestegard, T. Acton, 2012, Biochemistry.

Structural basis for the methylation of A1408 in 16S rRNA by a panaminoglycoside resistance methyltransferase NpmA from a clinical isolate and analysis of the NpmA interactions with the 30S ribosomal subunit

J. Bujnicki, J. Seetharaman, N. Husain, 2010, Nucleic acids research.

NMR and X-RAY structures of human E2-like ubiquitin-fold modifier conjugating enzyme 1 (UFC1) reveal structural and functional conservation in the metazoan UFM1-UBA5-UFC1 ubiquination pathway

B. Rost, Gaohua Liu, G. Montelione, 2009, Journal of Structural and Functional Genomics.

Structure of a novel phosphotyrosine‐binding domain in Hakai that targets E‐cadherin

J. Seetharaman, S. Sze, Y. Lim, 2012, The EMBO journal.

Structure and dynamics of the P7 protein from the bacteriophage phi 12.

P. Gottlieb, K. Dutta, J. Hunt, 2008, Journal of molecular biology.

Molecular basis for catalysis and substrate-mediated cellular stabilization of human tryptophan 2,3-dioxygenase

L. Tong, F. Forouhar, J. Seetharaman, 2016, Scientific Reports.

Crystal Structures of Malonyl-Coenzyme A Decarboxylase Provide Insights into Its Catalytic Mechanism and Disease-Causing Mutations

G. Montelione, F. von Delft, C. Allerston, 2013, Structure.

Solution NMR and X-ray crystal structures of Pseudomonas syringae Pspto_3016 from protein domain family PF04237 (DUF419) adopt a “double wing” DNA binding motif

G. Montelione, T. Acton, L. Tong, 2012, Journal of Structural and Functional Genomics.

The structural basis of cyclic diguanylate signal transduction by PilZ domains

S. Handelman, H. Neely, F. Forouhar, 2007, The EMBO journal.

X-ray structure of 3-phenylthio-2-[1′-phenylsulfonyl-2′(3-pyridyl)vinyl]indole and its interaction with calf thymus DNA by spectroscopic methods

D. Velmurugan, J. Seetharaman, J. Sivaraman, 1996 .

X-ray crystal structure of the human galectin-3 carbohydrate recognition domain at 2.1-A resolution.

S. Barondes, J. Seetharaman, J. Rini, 1998, The Journal of biological chemistry.

Unraveling the Structural Basis of Selective Inhibition of Human Cytochrome P450 3A5.

Andrew D. Huber, Taosheng Chen, J. Seetharaman, 2021, Journal of the American Chemical Society.

Novel C-terminal Motif within Sec7 Domain of Guanine Nucleotide Exchange Factors Regulates ADP-ribosylation Factor (ARF) Binding and Activation*

G. Montelione, T. Acton, L. Tong, 2011, The Journal of Biological Chemistry.

Crystal Structure of Schizosaccharomyces pombe Rho1 Reveals Its Evolutionary Relationship with Other Rho GTPases

J. Seetharaman, Jiarong Xie, Qingqing Huang, 2022, Biology.

Crystal and molecular structure of noscapine1

J. Seetharaman, S. Rajan, 1995 .

X-ray structure of 5-[2-chlorophenyl]-10-[4-methylphenyl] 1,2,5,8,9,10 hexahydro 4,6[3H,6H] acridinedione and its interaction with calf thymus DNA by spectroscopic methods

D. Velmurugan, J. Seetharaman, J. Sivaraman, 1996 .

Computational design of enone-binding proteins with catalytic activity for the Morita-Baylis-Hillman reaction.

Jayaraman Seetharaman, Gert Kiss, K N Houk, 2013, ACS chemical biology.

A community resource of experimental data for NMR / X‐ray crystal structure pairs

Rong Xiao, Robert Powers, Thomas Szyperski, 2016, Protein science : a publication of the Protein Society.

Three structural representatives of the PF06855 protein domain family from Staphyloccocus aureus and Bacillus subtilis have SAM domain-like folds and different functions

G. Montelione, T. Acton, L. Tong, 2012, Journal of Structural and Functional Genomics.

Identification of the ice-binding surface on a type III antifreeze protein with a "flatness function" algorithm.

F. Sicheri, J. Seetharaman, C. Hew, 1998, Biophysical journal.

Structure and Evolutionary Origin of Ca2+-Dependent Herring Type II Antifreeze Protein

J. Bujnicki, J. Kosiński, J. Seetharaman, 2007, PloS one.

Structure of the DNA-binding and RNA-polymerase-binding region of transcription antitermination factor λQ.

G. Montelione, R. Ebright, S. Vorobiev, 2014, Structure.

Crystal structure of trehalose‐6‐phosphate phosphatase–related protein: Biochemical and biological implications

S. Burley, J. Bonanno, S. Swaminathan, 2006, Protein Science.

Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase

Sarah J. Thackray, G. Montelione, T. Acton, 2007, Proceedings of the National Academy of Sciences.

Molecular Insights into the Biosynthesis of the F420 Coenzyme*

Robert H. White, G. Montelione, T. Acton, 2008, Journal of Biological Chemistry.

X-ray Crystal Structure of the Human Galectin-3 Carbohydrate Recognition Domain at 2.1-Å Resolution*

S. Barondes, J. Seetharaman, J. Rini, 1998, The Journal of Biological Chemistry.

Structure of AcrH-AopB Chaperone-Translocator Complex Reveals a Role for Membrane Hairpins in Type III Secretion System Translocon Assembly.

Yunhan Hong, J. Seetharaman, K. Leung, 2015, Structure.

Structure of AcrH – AopB C haperone-Translocator Complex Reveals a Role for Membrane Hairpins in Type III Secretion System Translocon Assembly Graphical

Yunhan Hong, J. Seetharaman, K. Leung, 2015 .

Structural and mechanistic characterization of leukocyte-type core 2 β1,6-N-acetylglucosaminyltransferase: a metal-ion-independent GT-A glycosyltransferase.

J. Seetharaman, J. Rini, M. Satkunarajah, 2011, Journal of molecular biology.

Enzymatic Basis for N-Glycan Sialylation

G. Montelione, R. Woods, L. Tong, 2013, The Journal of Biological Chemistry.

Dimerization of Hepatitis E Virus Capsid Protein E2s Domain Is Essential for Virus–Host Interaction

J. Seetharaman, C. Hew, N. Xia, 2009, PLoS pathogens.

Structures of human phosphofructokinase-1 and atomic basis of cancer-associated mutations

Liang Tong, Farhad Forouhar, Jayaraman Seetharaman, 2015, Nature.

Structural basis for the pathogenesis of Campylobacter jejuni Hcp1, a structural and effector protein of the Type VI Secretion System

J. Seetharaman, Zobia Noreen, H. Bokhari, 2018, The FEBS journal.

Allosteric regulation and substrate activation in cytosolic nucleotidase II from Legionella pneumophila

G. Montelione, H. Balaram, T. Acton, 2014, The FEBS journal.

Two Fe-S clusters catalyze sulfur insertion by radical-SAM methylthiotransferases.

G. Montelione, T. Acton, R. Xiao, 2013, Nature chemical biology.

The structure and enzymatic properties of a novel RNase II family enzyme from Deinococcus radiodurans.

J. Hunt, J. Seetharaman, M. Deutscher, 2012, Journal of molecular biology.

A large conformational change in the putative ATP pyrophosphatase PF0828 induced by ATP binding.

G. Montelione, T. Acton, L. Tong, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

UNC119 is required for G protein trafficking in sensory neurons

M. Davis, E. Jorgensen, G. Montelione, 2011, Nature Neuroscience.

Structures of domains I and IV from YbbR are representative of a widely distributed protein family

G. Montelione, J. Prestegard, T. Acton, 2011, Protein science : a publication of the Protein Society.

Structures of bacterial biosynthetic arginine decarboxylases.

G. Montelione, T. Acton, L. Tong, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural and Functional Studies of the Abundant Tegument Protein ORF52 from Murine Gammaherpesvirus 68*

G. Montelione, R. Sun, T. Acton, 2007, Journal of Biological Chemistry.

Functional insights from structural genomics

Weihong Zhou, Liang Tong, Farhad Forouhar, 2007, Journal of Structural and Functional Genomics.

Crystal structure of AGR_C_4470p from Agrobacterium tumefaciens

G. Montelione, T. Acton, S. Vorobiev, 2007, Protein science : a publication of the Protein Society.

A bidirectional system for the dynamic small molecule control of intracellular fusion proteins.

G. Montelione, T. Acton, L. Tong, 2013, ACS chemical biology.

Structure and Mechanisms of NT5C2 Mutations Driving Thiopurine Resistance in Relapsed Lymphoblastic Leukemia.

A. Ferrando, A. Ambesi-Impiombato, L. Tong, 2018, Cancer cell.

Structural genomics reveals EVE as a new ASCH/PUA‐related domain

Marco Punta, Weihong Zhou, Liang Tong, 2009, Proteins.

Structural Insights into Immune Recognition of the Severe Acute Respiratory Syndrome Coronavirus S Protein Receptor Binding Domain

F. Plummer, J. Seetharaman, J. Rini, 2009, Journal of Molecular Biology.

Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation

Andrew D. Huber, Taosheng Chen, J. Seetharaman, 2022, Nucleic acids research.

Expression system for structural and functional studies of human glycosylation enzymes.

J. LaBaer, L. Tong, F. Forouhar, 2018, Nature chemical biology.

Target highlights in CASP9: Experimental target structures for the critical assessment of techniques for protein structure prediction

Mark J van Raaij, Liang Tong, Torsten Schwede, 2011, Proteins.

Structural basis of BAK activation in mitochondrial apoptosis initiation

J. Seetharaman, D. McNamara, M. B. Waddell, 2022, Nature Communications.

Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19

Jing Chen, Liang Tong, Yunhuang Yang, 2014, ACS chemical biology.

Crystal structure of a catalytically active GG(D/E)EF diguanylate cyclase domain from Marinobacter aquaeolei with bound c-di-GMP product

G. Montelione, T. Acton, S. Vorobiev, 2012, Journal of Structural and Functional Genomics.

The genome of a Bacteroidetes inhabitant of the human gut encodes a structurally distinct enoyl-acyl carrier protein reductase (FabI)

C. Rock, J. Seetharaman, Darcie J. Miller, 2020, The Journal of Biological Chemistry.

Crystal structure of chromosome partitioning protein (ParA) in complex with ADP from Synechocystis sp. Northeast Structural Genomics Consortium Target SgR89

G. Montelione, T. Acton, L. Tong, 2008 .

The impact of strategy on public sector set-aside programs: the case of the state of Ohio

J. Seetharaman, T. Brown, Ian Y. Blount, 2018 .

Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis

Julie C. Mitchell, M. Westphall, R. Wrobel, 2014, Proceedings of the National Academy of Sciences.

Crystal structure of fatty acid-binding protein-like Ycf58 from Thermosynecoccus elongatus. Northeast Structural Genomics Consortium target TeR13.

B. Rost, G. Montelione, M. Baran, 2007 .

Structure Determination and Biochemical Characterization of a Putative HNH Endonuclease from Geobacter metallireducens GS-15

G. Montelione, T. Acton, L. Tong, 2013, PloS one.

Dimerization of VirD2 Binding Protein Is Essential for Agrobacterium Induced Tumor Formation in Plants

A. Velázquez‐Campoy, J. Seetharaman, S. Pan, 2014, PLoS pathogens.

Computational design of an unnatural amino acid dependent metalloprotein with atomic level accuracy.

Liang Tong, Vikram Khipple Mulligan, Barry L. Stoddard, 2013, Journal of the American Chemical Society.

Structural basis of BAK activation in mitochondrial apoptosis initiation

J. Seetharaman, D. McNamara, M. B. Waddell, 2022, Nature communications.

Design of activated serine-containing catalytic triads with atomic level accuracy

David Baker, B. Cravatt, Florian Richter, 2014, Nature chemical biology.

Water Networks Repopulate Protein–Ligand Interfaces with Temperature

J. Seetharaman, M. Fischer, T. Stachowski, 2022, Angewandte Chemie.

Molecular Insights into the Biosynthesis of the F 420 Coenzyme *

Robert H. White, G. Montelione, T. Acton, 2008 .

Three dimensional structure of the double mutant of UPF0176 protein lpg2838 from Legionella pneumophila at the resolution 1.8A, Northeast Structural Genomics Consortium (NESG) Target LgR82

G. Montelione, T. Acton, L. Tong, 2012 .

Structural Basis for the Modulation of the Neuronal Voltage-Gated Sodium Channel NaV1.6 by Calmodulin

Yucheng Xiao, J. Seetharaman, T. Cummins, 2013, Scientific Reports.

Crystal structures of two putative phosphoheptose isomerases

S. Burley, J. Bonanno, S. Swaminathan, 2006, Proteins.

Crystal Structure of 3-octaprenyl-4-hydroxybenzoate decarboxylase (UbiD) from Escherichia coli, Northeast Structural Genomics Target ER459.

G. Montelione, T. Acton, L. Tong, 2006 .

Structural Basis for the Interaction of Unstructured Neuron Specific Substrates Neuromodulin and Neurogranin with Calmodulin

Fwu-Shan Sheu, Ling Zhong, A. Velázquez‐Campoy, 2013, Scientific Reports.

Human retinoblastoma binding protein 9, a serine hydrolase implicated in pancreatic cancers.

G. Montelione, T. Acton, S. Vorobiev, 2012, Protein and peptide letters.

Crystal structure of abrine

J. Seetharaman, R. Srinivasan, S. Rajan, 1993 .

Crystal structure of a fructokinase homolog from Halothermothrix orenii.

Joanna M. Kasprzak, J. Bujnicki, B. Patel, 2010, Journal of Structural Biology.

Structure-guided approach to modulate small molecule binding to a promiscuous ligand-activated protein

Andrew D. Huber, Taosheng Chen, J. Seetharaman, 2023, Proceedings of the National Academy of Sciences of the United States of America.

Computational design of a protein-based enzyme inhibitor.

G. Montelione, S. Fleishman, J. Hunt, 2013, Journal of molecular biology.

UNC119 is required for G protein trafficking in sensory neurons

M. Davis, E. Jorgensen, G. Montelione, 2011, Nature Neuroscience.

Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase

Sarah J. Thackray, G. Montelione, T. Acton, 2007, Proceedings of the National Academy of Sciences.

Structural genomics reveals EVE as a new ASCH/PUA‐related domain

B. Rost, G. Montelione, M. Punta, 2009, Proteins.

Crystal structure of human Cep57 C-terminal domain reveals the presence of leucine zipper and the potential microtubule binding region.

J. Seetharaman, S. Lew, Sanskrita Sukla, 2024, Proteins: Structure, Function, and Bioinformatics.

A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR

Taosheng Chen, J. Seetharaman, S. Chai, 2023, Nucleic acids research.

Expression system for structural and functional studies of human glycosylation enzymes.

J. LaBaer, F. Forouhar, J. Seetharaman, 2018, Nature chemical biology.

The Use of Observed Amino Acid Composition in the Proteins to the Analysis of the Sense and Antisense Strands Of DNA

J. Seetharaman, R. Srinivasan, 1995 .