M. Altman

发表

Computational design and experimental study of tighter binding peptides to an inactivated mutant of HIV‐1 protease

B. Tidor, C. Schiffer, M. Altman, 2008, Proteins.

Computational ligand design and analysis in protein complexes using inverse methods, combinatorial search, and accurate solvation modeling

M. Altman, 2006 .

Biological surface engineering: a simple system for cell pattern formation.

G M Whitesides, D A Lauffenburger, D. Lauffenburger, 1999, Biomaterials.

A Curved Panel Integration Technique for Molecular Surfaces

Jacob K. White, Jaydeep P. Bardhan, Bruce Tidor, 2005 .

Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.

Jongwon Lim, Michael D Altman, Craig Rosenstein, 2011, Journal of medicinal chemistry.

Molecular mechanism of action of pharmacoperone rescue of misrouted GPCR mutants: the GnRH receptor.

T. Rush, M. Altman, A. Cornea, 2009, Molecular endocrinology.

Development of a High-Throughput Gene Expression Screen for Modulators of RAS-MAPK Signaling in a Mutant RAS Cellular Context

Marc Ferrer, Michelle A Cleary, Michael D Altman, 2016, Journal of biomolecular screening.

Linking High-Throughput Screens to Identify MoAs and Novel Inhibitors of Mycobacterium tuberculosis Dihydrofolate Reductase.

Peter S. Kutchukian, M. Glick, M. Altman, 2017, ACS chemical biology.

Projected Dose Optimization of Amino- and Hydroxypyrrolidine Purine PI3Kδ Immunomodulators.

M. Altman, X. Fradera, Hongshi Yu, 2021, Journal of medicinal chemistry.

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.

T. Fischmann, M. Altman, X. Fradera, 2019, Journal of medicinal chemistry.

Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications.

Duan Liu, M. Altman, Ruojing Yang, 2015, Bioorganic & medicinal chemistry letters.

Allosteric Modulation of Protein Arginine Methyltransferase 5 (PRMT5).

M. Altman, Haiyan Xu, P. Siliphaivanh, 2020, ACS medicinal chemistry letters.

Design and synthesis of unprecedented 9- and 10-membered cyclonucleosides with PRMT5 inhibitory activity.

M. Altman, Christopher Sondey, J. Saurí, 2022, Bioorganic & medicinal chemistry.

Substrate envelope-designed potent HIV-1 protease inhibitors to avoid drug resistance.

Hong Cao, Bruce Tidor, Nese Kurt Yilmaz, 2013, Chemistry & biology.

Evaluating the Substrate-Envelope Hypothesis: Structural Analysis of Novel HIV-1 Protease Inhibitors Designed To Be Robust against Drug Resistance

Michael K. Gilson, Hong Cao, Bruce Tidor, 2010, Journal of Virology.

An unexpected aminocyclopropane reductive rearrangement

M. Altman, J. Methot, Dawn M. Mampreian, 2008 .

Discovery of 5-Amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamide Inhibitors of IRAK4.

T. Fischmann, M. Altman, Ruojing Yang, 2015, ACS medicinal chemistry letters.

Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.

K. Kunii, M. Altman, A. Szewczak, 2011, Journal of medicinal chemistry.

Interpretation of in Vitro Metabolic Stability Studies for Racemic Mixtures.

M. Altman, Iain J Martin, J. Baker, 2018, ACS medicinal chemistry letters.

Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer.

Andrew M Haidle, Matthew L. Maddess, J. Cumming, 2022, Journal of medicinal chemistry.

A kinase-cGAS cascade to synthesize a therapeutic STING activator

Steven P. Miller, Paul N. Devine, Matthew L. Maddess, 2022, Nature.

Analyzing the Potential Root Causes of Variability of Pharmacokinetics in Preclinical Species.

Kung-I Feng, M. Altman, M. Cartwright, 2017, Molecular pharmaceutics.

The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead.

T. Rush, M. Altman, Joon Jung, 2010, Bioorganic & medicinal chemistry letters.

Peptide self-assembly in functional polymer science and engineering

Michael D. Altman, Shuguang Zhang, Shuguang Zhang, 1999 .

An orally available non-nucleotide STING agonist with antitumor activity

Andrew M Haidle, J. Cumming, I. Kariv, 2020, Science.

Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms.

Thomas Rush, Andrew M Haidle, Michael D Altman, 2014, Bioorganic & medicinal chemistry letters.

Testing the Substrate-Envelope Hypothesis with Designed Pairs of Compounds

Hong Cao, Bruce Tidor, Celia A. Schiffer, 2013, ACS chemical biology.

A "Reverse-Schur" Approach to Optimization With Linear PDE Constraints: Application to Biomolecule Analysis and Design.

Jacob K. White, Jaydeep P Bardhan, Jacob K White, 2009, Journal of chemical theory and computation.

Effects of the bovine SLICK1 mutation in PRLR on sweat gland area, FOXA1 abundance, and global gene expression in skin.

T. Sonstegard, M. Altman, S. Dikmen, 2022, Journal of dairy science.

Discovery of MK-4688: an Efficient Inhibitor of the HDM2-p53 Protein-Protein Interaction.

G. Scapin, M. Altman, X. Fradera, 2021, Journal of medicinal chemistry.

Robust against Drug Resistance HIV-1 Protease Inhibitors Designed To Be Hypothesis: Structural Analysis of Novel Evaluating the Substrate-Envelope

B. Tidor, M. Gilson, C. Schiffer, 2014 .

Design of selective PI3Kδ inhibitors using an iterative scaffold-hopping workflow.

M. Augustin, M. Altman, X. Fradera, 2019, Bioorganic & medicinal chemistry letters.

Evaluation of an inverse molecular design algorithm in a model binding site

Bruce Tidor, David J Huggins, Michael D Altman, 2009, Proteins.

Numerical integration techniques for curved-element discretizations of molecule-solvent interfaces.

Jacob K. White, Bruce Tidor, Jaydeep P Bardhan, 2007, The Journal of chemical physics.

FFTSVD: A Fast Multiscale Boundary-Element Method Solver Suitable for Bio-MEMS and Biomolecule Simulation

Jacob K. White, Jaydeep P. Bardhan, Bruce Tidor, 2006, IEEE Transactions on Computer-Aided Design of Integrated Circuits and Systems.

Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.

Wei Lu, Michael D Altman, Craig Rosenstein, 2013, Journal of medicinal chemistry.

Design of Mutation‐resistant HIV Protease Inhibitors with the Substrate Envelope Hypothesis

Hong Cao, Bruce Tidor, Michael K Gilson, 2007, Chemical biology & drug design.

Discovery of a new series of PI3K-δ inhibitors from Virtual Screening.

M. Augustin, M. Altman, X. Fradera, 2021, Bioorganic & medicinal chemistry letters.

Discovery of a Novel cGAMP Competitive Ligand of the Inactive Form of STING.

M. Altman, H. Hatch, B. Pan, 2018, ACS medicinal chemistry letters.

Efficient optimization of electrostatic interactions between biomolecules

Jacob K. White, Jaydeep P. Bardhan, Bruce Tidor, 2007, 2007 46th IEEE Conference on Decision and Control.

An Accurate Surface Formulation for Biomolecule Electrostatics in Non-Ionic Solutions

B. Tidor, M. Altman, J. Bardhan, 2005, 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference.

Fast methods for simulation of biomolecule electrostatics

Jacob K. White, Jaydeep P. Bardhan, Bruce Tidor, 2002, IEEE/ACM International Conference on Computer Aided Design, 2002. ICCAD 2002..

Strategy for Extending Half-life in Drug Design and Its Significance.

M. Altman, B. Lahue, Scott A. Johnson, 2018, ACS medicinal chemistry letters.

Accurate solution of multi‐region continuum biomolecule electrostatic problems using the linearized Poisson–Boltzmann equation with curved boundary elements

Jacob K. White, Jaydeep P. Bardhan, Bruce Tidor, 2009, J. Comput. Chem..

HIV-1 protease inhibitors from inverse design in the substrate envelope exhibit subnanomolar binding to drug-resistant variants.

Hong Cao, Bruce Tidor, Michael K Gilson, 2008, Journal of the American Chemical Society.

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.

Duan Liu, T. Fischmann, M. Altman, 2017, Bioorganic & medicinal chemistry letters.

Carboxamide Spleen Tyrosine Kinase (Syk) Inhibitors: Leveraging Ground State Interactions To Accelerate Optimization.

Andrew M Haidle, Matthew L. Maddess, Youwei Yan, 2016, ACS medicinal chemistry letters.

Overcoming mutagenicity and ion channel activity: optimization of selective spleen tyrosine kinase inhibitors.

Matthew L. Maddess, H. Houshyar, M. Altman, 2015, Journal of medicinal chemistry.

Additivity in the analysis and design of HIV protease inhibitors.

Bruce Tidor, Michael K Gilson, Akbar Ali, 2009, Journal of medicinal chemistry.

Structure guided design of a series of selective pyrrolopyrimidinone MARK inhibitors.

Andrew M Haidle, H. Su, S. Munshi, 2017, Bioorganic & medicinal chemistry letters.

Optimization of microtubule affinity regulating kinase (MARK) inhibitors with improved physical properties.

H. Su, S. Munshi, S. Edavettal, 2016, Bioorganic & medicinal chemistry letters.

MARK inhibitors: Declaring a No-Go decision on a chemical series based on extensive DMPK experimentation.

Andrew M Haidle, M. Altman, A. Szewczak, 2017, Bioorganic & medicinal chemistry letters.

Fast Methods for Biomolecule Charge Optimization

S. S. Kuo, B. Tidor, M. Altman, 2002 .

Self-assembling Peptide Systems in Biology and Biomedical Engineering

Shuguang Zhang, M. Altman, 2002 .

Self-assembling peptides in biology, materials science and engineering

Rodney K. Chan, M. Altman, S. Zhang, 1999 .

Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer.

V. Serebrov, M. Altman, Yingzi Yue, 2021, European journal of medicinal chemistry.

Identification of quinazoline based inhibitors of IRAK4 for the treatment of inflammation.

Duan Liu, T. Fischmann, M. Altman, 2017, Bioorganic & medicinal chemistry letters.

Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications.

Duan Liu, M. Altman, Ruojing Yang, 2015, Bioorganic & medicinal chemistry letters.