Matthew E. Gosden

发表

DeepC: Predicting chromatin interactions using megabase scaled deep neural networks and transfer learning

Yee Whye Teh, Jelena Telenius, Gerton Lunter, 2019, bioRxiv.

Tissue-specific CTCF/Cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

Matthew E. Gosden, D. Downes, J. Hughes, 2017, Nature Cell Biology.

An integrated platform to systematically identify causal variants and genes for polygenic human traits

Calliope A. Dendrou, J. Todd, G. Lunter, 2019, bioRxiv.

Dynamics of the 4D genome during in vivo lineage specification and differentiation

Daniel Hidalgo, M. Socolovsky, J. Telenius, 2020, Nature Communications.

Targeted high-resolution chromosome conformation capture at genome-wide scale

J. Telenius, R. Schwessinger, Matthew E. Gosden, 2020, bioRxiv.

Multipartite super-enhancers function in an orientation-dependent manner

Matthew E. Gosden, D. Downes, J. Hughes, 2022, bioRxiv.

The chromatin remodeller ATRX facilitates diverse nuclear processes, in a stochastic manner, in both heterochromatin and euchromatin

R. Schwessinger, Matthew E. Gosden, D. Downes, 2022, Nature Communications.

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

P. Sopp, P. Vyas, Matthew E. Gosden, 2017, Nature Communications.

A functional overlap between actively transcribed genes and chromatin boundary elements

Matthew E. Gosden, D. Downes, J. Hughes, 2020, bioRxiv.

DeepC: predicting 3D genome folding using megabase-scale transfer learning

Yee Whye Teh, Gerton Lunter, Jim R Hughes, 2020, Nature Methods.

Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

Jelena Telenius, Damien J Downes, Ita Costello, 2017, Development.

Recapitulation of erythropoiesis in congenital dyserythropoietic anemia type I (CDA-I) identifies defects in differentiation and nucleolar abnormalities

M. Brand, D. Ferguson, R. Schwessinger, 2020, Haematologica.

High-resolution targeted 3C interrogation of cis-regulatory element organization at genome-wide scale

R. Schwessinger, Matthew E. Gosden, D. Downes, 2021, Nature Communications.

Scalable in vitro production of defined mouse erythroblasts

Matthew E. Gosden, D. Higgs, Mira T Kassouf, 2020, bioRxiv.

Modelling erythropoiesis in congenital dyserythropoietic anaemia type I (CDA-I)

M. Brand, D. Ferguson, R. Schwessinger, 2019, bioRxiv.

Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation

M. McCarthy, A. Gloyn, R. Bowden, 2019, Stem cell reports.

Dissection of the 4D chromatin structure of the α-globin locus through in vivo erythroid differentiation with extreme spatial and temporal resolution

Daniel Hidalgo, M. Socolovsky, Matthew E. Gosden, 2019, bioRxiv.

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

P. Sopp, P. Vyas, Matthew E. Gosden, 2017, Nature Communications.

Dynamics of the 4D genome during lineage specification, differentiation and maturation in vivo

Daniel Hidalgo, M. Socolovsky, Matthew E. Gosden, 2019 .