J. Sharpe

发表

Tissue-specific CTCF/Cohesin-mediated chromatin architecture delimits enhancer interactions and function in vivo

Matthew E. Gosden, D. Downes, J. Hughes, 2017, Nature Cell Biology.

Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype.

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2002, Blood.

Genetic dissection of the α-globin super-enhancer in vivo

L. Pennacchio, J. Telenius, J. Hughes, 2016, Nature Genetics.

Nprl3 is required for normal development of the cardiovascular system

Monika S. Kowalczyk, C. Ponting, S. Bhattacharya, 2012, Mammalian Genome.

Defining the cause of skewed X-chromosome inactivation in X-linked mental retardation by use of a mouse model.

P. Nolan, D. Higgs, J. Sharpe, 2007, American journal of human genetics.

Loss of Atrx Affects Trophoblast Development and the Pattern of X-Inactivation in Extraembryonic Tissues

D. Higgs, J. Sharpe, R. Gibbons, 2006, PLoS genetics.

Characterization of the major regulatory element upstream of the human alpha-globin gene cluster

A. Jarman, D. Higgs, J. Sharpe, 1991, Molecular and cellular biology.

Understanding alpha globin gene expression: a step towards effective gene therapy.

D. Higgs, J. Sharpe, W. Wood, 1998, Seminars in hematology.

Multipartite super-enhancers function in an orientation-dependent manner

Matthew E. Gosden, D. Downes, J. Hughes, 2022, bioRxiv.

Analysis of a 70 kb segment of DNA containing the human zeta and alpha-globin genes linked to their regulatory element (HS-40) in transgenic mice.

D. Higgs, J. Sharpe, W. Wood, 1994, Nucleic acids research.

The chromatin remodelling factor ATRX suppresses R‐loops in transcribed telomeric repeats

T. Jenuwein, D. Higgs, J. Sharpe, 2017, EMBO reports.

A single beta-globin locus control region element (5' hypersensitive site 2) is sufficient for developmental regulation of human globin genes in transgenic mice

J. Sharpe, C. Abbott, W. Wood, 1992, Molecular and cellular biology.

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

P. Sopp, P. Vyas, Matthew E. Gosden, 2017, Nature Communications.

Gene expression in somatic cell hybrids derived from embryonic mice transgenic for human globin genes

N. Roberts, J. Sharpe, W. Wood, 1996, British journal of haematology.

A functional overlap between actively transcribed genes and chromatin boundary elements

Matthew E. Gosden, D. Downes, J. Hughes, 2020, bioRxiv.

Reactivation of a developmentally silenced embryonic globin gene

S. Orkin, L. Pennacchio, D. Downes, 2021, Nature Communications.

Intragenic enhancers act as alternative promoters.

Monika S. Kowalczyk, Thomas A Milne, Douglas R Higgs, 2012, Molecular cell.

Manipulating the Mouse Genome to Engineer Precise Functional Syntenic Replacements with Human Sequence

J. Hughes, D. Higgs, J. Sharpe, 2007, Cell.

A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype.

J. Sharpe, J. Sloane-Stanley, L. Strmečki, 2000, Human molecular genetics.

Transcription of antisense RNA leading to gene silencing and methylation as a novel cause of human genetic disease

D. Higgs, J. Sharpe, H. Ayyub, 2003, Nature Genetics.

alpha-thalassemia resulting from a negative chromosomal position effect.

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2000, Blood.

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

I. Dunham, Christoph M. Koch, J. Hughes, 2007, Blood.

Analysis of the human alpha globin upstream regulatory element (HS‐40) in transgenic mice.

D. Higgs, J. Sharpe, H. Ayyub, 1992, The EMBO journal.

Enhancers predominantly regulate gene expression in vivo via transcription initiation

M. Bender, R. Schwessinger, D. Downes, 2019, bioRxiv.

Polycomb eviction as a new distant enhancer function.

Douglas R Higgs, David Garrick, D. Higgs, 2011, Genes & development.

Analysis of the human alpha-globin gene cluster in transgenic mice.

P. Vyas, D. Higgs, J. Sharpe, 1993, Proceedings of the National Academy of Sciences of the United States of America.

A major positive regulatory region located far upstream of the human alpha-globin gene locus.

A. Jarman, D. Higgs, J. Sharpe, 1990, Genes & development.

Skeletal analysis of the Fgfr3P244R mouse, a genetic model for the Muenke craniosynostosis syndrome

Gillian M Morriss-Kay, Christian Babbs, S. Twigg, 2009, Developmental dynamics : an official publication of the American Association of Anatomists.

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

J. Hughes, D. Higgs, J. Sharpe, 2012, The EMBO journal.

Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.

P. Vyas, D. Higgs, J. Sharpe, 1995, The EMBO journal.

Globin gene switching in transgenic mice carrying HS2-globin gene constructs.

N. Roberts, J. Sharpe, J. Sloane-Stanley, 1997, Blood.

Analysis of the human a-globin gene cluster in transgenic mice

D. Higgs, J. Sharpe, W. Wood, 2005 .

Role of upstream DNase I hypersensitive sites in the regulation of human alpha globin gene expression.

P. Vyas, D. Higgs, J. Sharpe, 1993, Blood.

Alpha-thalassemia caused by a large (62 kb) deletion upstream of the human alpha globin gene cluster.

A. Wilkie, D. Higgs, J. Sharpe, 1990, Blood.

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1{alpha} localization in erythroblasts.

D. Ferguson, L. Bird, D. Higgs, 2010, Blood.

Deletion of the mouse alpha-globin regulatory element (HS -26) has an unexpectedly mild phenotype.

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2002, Blood.

Established epigenetic modifications determine the expression of developmentally regulated globin genes in somatic cell hybrids

N. Roberts, J. Sharpe, J. Sloane-Stanley, 1995, Molecular and cellular biology.

Enhancer deletion generates cellular phenotypic diversity due to bimodal gene expression.

J. Sharpe, J. Sloane-Stanley, M. De Gobbi, 2017, Blood cells, molecules & diseases.

The mouse alpha-globin locus regulatory element.

D. Higgs, J. Sharpe, W. Wood, 1995, Blood.

Regulation of human embryonic globin genes zeta 2 and epsilon in stably transformed mouse erythroleukemia cells.

P. Vyas, D. Higgs, J. Sharpe, 1992, Blood.

On-microscope staging of live cells reveals changes in the dynamics of transcriptional bursting during differentiation

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2021, bioRxiv.

Chromosome looping at the human alpha-globin locus is mediated via the major upstream regulatory element (HS -40).

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2009, Blood.

unexpectedly mild phenotype globin regulatory element (HS -26) has an α Deletion of the mouse

J. Sharpe, J. Sloane-Stanley, C. Tufarelli, 2013 .

A Single 13-Globin LocusControl RegionElement (5'Hypersensitive Site2)IsSufficient forDevelopmental Regulation ofHumanGlobin GenesinTransgenic Mice

J. Sharpe, W. Wood, J. Lida, 1992 .

Nprl3 is required for normal development of the cardiovascular system

Monika S. Kowalczyk, C. Ponting, S. Bhattacharya, 2012, Mammalian Genome.

Editing an α-globin enhancer in primary human hematopoietic stem cells as a treatment for β-thalassemia

P. Sopp, P. Vyas, Matthew E. Gosden, 2017, Nature Communications.

Proximal promoter elements of the human zeta-globin gene confer embryonic-specific expression on a linked reporter gene in transgenic mice.

J. Sharpe, L. Pearson, N. Proudfoot, 1996, Nucleic acids research.

Tissue-specific histone modification and transcription factor binding in alpha globin gene expression.

I. Dunham, Christoph M. Koch, J. Hughes, 2007, Blood.

Codanin-1 mutations in congenital dyserythropoietic anemia type 1 affect HP1 (cid:1) localization in erythroblasts

J. Sharpe, J. Sloane-Stanley, T. Hassanali, 2011 .

An interspecies analysis reveals a key role for unmethylated CpG dinucleotides in vertebrate Polycomb complex recruitment

J. Hughes, D. Higgs, J. Sharpe, 2012, EMBO Journal.

Polycomb eviction as a new distant enhancer function.

D. Higgs, J. Sharpe, J. Sloane-Stanley, 2011, Genes & development.