F. Simonin

发表

Mice deficient for δ- and μ-opioid receptors exhibit opposing alterations of emotional responses

A. Dierich, D. Filliol, S. Ghozland, 2000, Nature Genetics.

RF-amide neuropeptides and their receptors in Mammals: Pharmacological properties, drug development and main physiological functions.

F. Bihel, F. Simonin, B. Ilien, 2016, Pharmacology & therapeutics.

Decreased oral self-administration of alcohol in kappa-opioid receptor knock-out mice.

F. Simonin, B. Kieffer, C. Vadász, 2005, Alcoholism, clinical and experimental research.

The second zinc-finger domain of poly(ADP-ribose) polymerase determines specificity for single-stranded breaks in DNA.

J. Hoeijmakers, F. Simonin, G. de Murcia, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Detection of poly(ADP ribose) polymerase in crude extracts by activity-blot.

F. Simonin, G. de Murcia, J. Briand, 1991, Analytical biochemistry.

Comprehensive overview of biased pharmacology at the opioid receptors: biased ligands and bias factors.

F. Bihel, F. Simonin, D. Tourwé, 2021, RSC medicinal chemistry.

kappa-Opioid receptor in humans: cDNA and genomic cloning, chromosomal assignment, functional expression, pharmacology, and expression pattern in the central nervous system.

B. Bloch, M. Mattei, H. Matthes, 1995, Proceedings of the National Academy of Sciences of the United States of America.

Photoaffinity labelling of human poly(ADP-ribose) polymerase catalytic domain.

G. Schulz, F. Simonin, J. Ménissier-de murcia, 1997, The Biochemical journal.

Identification of a novel family of G protein‐coupled receptor associated sorting proteins

F. Simonin, B. Kieffer, A. Matifas, 2004, Journal of neurochemistry.

Dynorphin A as a potential endogenous ligand for four members of the opioid receptor gene family.

S. Zhang, F. Simonin, B. Kieffer, 1998, The Journal of pharmacology and experimental therapeutics.

The human delta-opioid receptor: genomic organization, cDNA cloning, functional expression, and distribution in human brain.

H. Matthes, F. Simonin, K. Befort, 1994, Molecular pharmacology.

Behavioral characterization, potential clinical relevance and mechanisms of latent pain sensitization.

F. Simonin, Manon Gerum, 2021, Pharmacology & therapeutics.

Amendment history : Corrigendum ( September 2017 ) Neuropeptide FF increases M 2 activation and self-renewal of adipose tissue macrophages

Jacqueline A. Brinkman, F. Simonin, J. Lim, 2019 .

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages.

Jacqueline A. Brinkman, Dudley Lamming, F. Simonin, 2017, The Journal of clinical investigation.

Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages

Jacqueline A. Brinkman, Dudley Lamming, F. Simonin, 2017, The Journal of clinical investigation.

Correction for Simonin et al., RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia

M. Parmentier, J. Bourguignon, J. Jhamandas, 2006, Proceedings of the National Academy of Sciences.

Expression and site-directed mutagenesis of the catalytic domain of human poly(ADP-ribose)polymerase in Escherichia coli. Lysine 893 is critical for activity.

C. Penning, F. Simonin, J. Ménissier-de murcia, 1990, The Journal of biological chemistry.

Development of Dipeptidic hGPR54 Agonists

F. Bihel, J. Bourguignon, F. Simonin, 2016, ChemMedChem.

The effect of neuropeptide FF in the amygdala kindling model

R. Raedt, K. Vonck, P. Boon, 2016, Acta neurologica Scandinavica.

Endogenous mammalian RF-amide peptides, including PrRP, kisspeptin and 26RFa, modulate nociception and morphine analgesia via NPFF receptors

T. Sorg, H. Meziane, F. Bihel, 2013, Neuropharmacology.

Involvement of Mammalian RF-Amide Peptides and Their Receptors in the Modulation of Nociception in Rodents

F. Simonin, Safia Ayachi, S. Ayachi, 2014, Front. Endocrinol..

Identification of a Novel Protein-Protein Interaction Motif Mediating Interaction of GPCR-Associated Sorting Proteins with G Protein-Coupled Receptors

F. Simonin, K. L. Martinez, M. Candusso, 2013, PloS one.

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

Brigitte L. Kieffer, Olga Valverde, Ian Kitchen, 1996, Nature.

Quantitative autoradiography of μ-,δ- and κ1 opioid receptors in κ-opioid receptor knockout mice

F. Simonin, B. Kieffer, I. Kitchen, 1999, Brain Research.

Recombinant Human Melatonin Receptor MT1 Isolated in Mixed Detergents Shows Pharmacology Similar to That in Mammalian Cell Membranes

O. Nosjean, G. Ferry, J. Boutin, 2014, PloS one.

RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia.

M. Parmentier, J. Bourguignon, J. Jhamandas, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Identification of an N-acylated-DArg-Leu-NH2 Dipeptide as a Highly Selective Neuropeptide FF1 Receptor Antagonist That Potently Prevents Opioid-Induced Hyperalgesia.

F. Bihel, F. Simonin, M. Schmitt, 2021, Journal of medicinal chemistry.

RF313, an orally bioavailable neuropeptide FF receptor antagonist, opposes effects of RF-amide-related peptide-3 and opioid-induced hyperalgesia in rodents

T. Sorg, H. Meziane, F. Bihel, 2017, Neuropharmacology.

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

F. Simonin, B. Ilien, Safia Ayachi, 2014, Journal of visualized experiments : JoVE.

Development of sub-nanomolar dipeptidic ligands of neuropeptide FF receptors.

F. Bihel, J. Bourguignon, F. Simonin, 2012, Bioorganic & medicinal chemistry letters.

Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments

H. Meziane, F. Bihel, J. Bourguignon, 2012, British journal of pharmacology.

Zinc-binding domain of poly(ADP-ribose)polymerase participates in the recognition of single strand breaks on DNA.

F. Simonin, J. Ménissier-de murcia, G. de Murcia, 1989, Journal of molecular biology.

Neuropeptide FF and neuropeptide VF inhibit GABAergic neurotransmission in parvocellular neurons of the rat hypothalamic paraventricular nucleus.

J. Bourguignon, J. Jhamandas, F. Simonin, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

The carboxyl-terminal domain of human poly(ADP-ribose) polymerase. Overproduction in Escherichia coli, large scale purification, and characterization.

F. Simonin, F. Althaus, G. de Murcia, 1993, The Journal of biological chemistry.

Poly(ADP—Ribose)Polymerase in Xenopus laevis

F. Simonin, M. Philippe, G. Murcia, 1992 .

Poly(ADP-ribose)polymerase: a novel finger protein.

F. Simonin, J. Ménissier-de murcia, G. de Murcia, 1989, Nucleic acids research.

Rapid and scalable synthesis of innovative unnatural α,β or γ-amino acids functionalized with tertiary amines on their side-chains.

F. Bihel, F. Simonin, M. Schmitt, 2015, Organic & biomolecular chemistry.

Trisubstitution of pyridine through sequential and regioselective palladium cross-coupling reactions affording analogs of known GPR54 antagonists

F. Bihel, J. Bourguignon, F. Simonin, 2013 .

Neuropeptide FF and prolactin‐releasing peptide decrease cortical excitability through activation of NPFF receptors

R. Raedt, K. Vonck, P. Boon, 2015, Epilepsia.

Opioid-induced hyperalgesia: Cellular and molecular mechanisms

F. Simonin, C. Gaveriaux-Ruff, Laurie-Anne Roeckel, 2016, Neuroscience.

In vitro pharmacological profile of peptide III-BTD: a novel ligand for nociceptin/orphanin FQ and opioid receptors.

F. Simonin, B. Kieffer, G. Calo’, 2000, Life sciences.

Bifunctional Peptide-Based Opioid Agonist-Nociceptin Antagonist Ligands for Dual Treatment of Acute and Neuropathic Pain.

F. Simonin, B. Mégarbane, P. Kosson, 2016, Journal of medicinal chemistry.

Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of μ-, δ- or κ-opioid receptor knockout mice

D. Filliol, H. Matthes, F. Simonin, 2001, Neuroscience.

Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide

F. Simonin, C. Gaveriaux-Ruff, J. Wood, 2017, Scientific Reports.

Impaired striatum‐dependent behavior in GASP‐1‐knock‐out mice

J. Cassel, F. Simonin, C. Mathis, 2011, Genes, brain, and behavior.

Attenuated behavioural responses to acute and chronic cocaine in GASP‐1‐deficient mice

F. Simonin, R. Maldonado, C. Mathis, 2009, The European journal of neuroscience.

Identification of κ‐ and δ‐opioid receptor transcripts in immune cells

F. Simonin, B. Kieffer, J. Laforet, 1995 .

Detection of opioid receptor mRNA by RT-PCR reveals alternative splicing for the δ- and κ-opioid receptors

F. Simonin, K. Befort, C. Gaveriaux-Ruff, 1997 .

Enhanced humoral response in kappa-opioid receptor knockout mice

D. Filliol, F. Simonin, C. Gaveriaux-Ruff, 2003, Journal of Neuroimmunology.

Aminoguanidine Hydrazone Derivatives as Nonpeptide NPFF1 Receptor Antagonists Reverse Opioid Induced Hyperalgesia.

F. Bihel, J. Bourguignon, F. Simonin, 2018, ACS chemical neuroscience.

Prolactin‐releasing peptide effects in the rat brain are mediated through the Neuropeptide FF receptor

Takeshi K. Watanabe, J. Bourguignon, J. Jhamandas, 2009, The European journal of neuroscience.

Mice deficient for delta- and mu-opioid receptors exhibit opposing alterations of emotional responses.

A. Dierich, D. Filliol, S. Ghozland, 2000, Nature genetics.

Overproduction and large-scale purification of the human poly(ADP-ribose) polymerase using a baculovirus expression system.

F. Simonin, J. Ménissier-de murcia, G. de Murcia, 1992, Gene.

Expression in E.coli of the catalytic domain of rat poly(ADP‐ribose)polymerase

F. Simonin, G. Poirier, J. Thibodeau, 1990, FEBS letters.

Immunosuppression by delta-opioid antagonist naltrindole: delta- and triple mu/delta/kappa-opioid receptor knockout mice reveal a nonopioid activity.

D. Filliol, H. Matthes, F. Simonin, 2001, The Journal of pharmacology and experimental therapeutics.

Immunosuppression by δ-Opioid Antagonist Naltrindole: δ- and Triple μ/δ/κ-Opioid Receptor Knockout Mice Reveal a Nonopioid Activity

D. Filliol, H. Matthes, F. Simonin, 2001 .

Development of a peptidomimetic antagonist of neuropeptide FF receptors for the prevention of opioid-induced hyperalgesia.

F. Bihel, J. Bourguignon, F. Simonin, 2015, ACS chemical neuroscience.

Erratum: Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages (The Journal of clinical investigation (2017) 127 7 (2842-2854) PII: 95841)

Jacqueline A. Brinkman, Dudley Lamming, F. Simonin, 2017 .

Motivational Effects of Cannabinoids Are Mediated by μ-Opioid and κ-Opioid Receptors

D. Filliol, S. Ghozland, H. Matthes, 2002, The Journal of Neuroscience.

Quantitative autoradiography of mu-,delta- and kappa1 opioid receptors in kappa-opioid receptor knockout mice.

F. Simonin, B. Kieffer, I. Kitchen, 1999, Brain research.

A bifunctional-biased mu-opioid agonist–neuropeptide FF receptor antagonist as analgesic with improved acute and chronic side effects

F. Bihel, F. Simonin, N. Frossard, 2018, Pain.

Characterization of delta, kappa, and mu human opioid receptors overexpressed in baculovirus-infected insect cells.

F. Simonin, B. Kieffer, F. Pattus, 1997, The Journal of biological chemistry.

Analysis of [3H]bremazocine binding in single and combinatorial opioid receptor knockout mice.

D. Filliol, J. Chluba, H. Matthes, 2001, European journal of pharmacology.

Motivational effects of cannabinoids are mediated by mu-opioid and kappa-opioid receptors.

D. Filliol, S. Ghozland, H. Matthes, 2002, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Detection of opioid receptor mRNA by RT-PCR reveals alternative splicing for the delta- and kappa-opioid receptors.

F. Simonin, K. Befort, C. Gaveriaux-Ruff, 1997, Brain research. Molecular brain research.

Identification and biological significance of G protein-coupled receptor associated sorting proteins (GASPs).

F. Simonin, Alaa Abu-Helo, 2010, Pharmacology & therapeutics.

Ligands for κ-Opioid and ORL1 Receptors Identified from a Conformationally Constrained Peptide Combinatorial Library*

F. Simonin, B. Kieffer, A. Pessi, 1999, The Journal of Biological Chemistry.

Disruption of the κ‐opioid receptor gene in mice enhances sensitivity to chemical visceral pain, impairs pharmacological actions of the selective κ‐agonist U‐50,488H and attenuates morphine withdrawal

B. Roques, A. Dierich, F. Simonin, 1998, The EMBO journal.

Morphine-induced hyperalgesia involves mu opioid receptors and the metabolite morphine-3-glucuronide

F. Simonin, C. Gaveriaux-Ruff, J. Wood, 2017, Scientific Reports.

Differential involvement of the Mu and Kappa opioid receptors in spatial learning

J. Roder, H. Matthes, F. Simonin, 2003, Genes, brain, and behavior.

Identification of kappa- and delta-opioid receptor transcripts in immune cells.

F. Simonin, B. Kieffer, J. Laforet, 1995, FEBS letters.

Autoradiographic mapping of the opioid receptor-like 1 (ORL1) receptor in the brains of mu-, delta- or kappa-opioid receptor knockout mice.

D. Filliol, H. Matthes, F. Simonin, 2001, Neuroscience.

Structure and function of the human poly(ADP-ribose) polymerase

F. Simonin, V. Schreiber, J. M. Murcia, 1992 .

Molecular Mechanisms of Opioid Dependence by Using Knockout Mice

F. Simonin, B. Kieffer, 2003 .

Two faces for an opioid peptide—and more receptors for pain research

F. Simonin, B. Kieffer, 2002, Nature Neuroscience.

Characterization of anti-GASP motif antibodies that inhibit the interaction between GPRASP1 and G protein-coupled receptors.

F. Simonin, G. Zeder‐Lutz, P. Villa, 2023, Analytical biochemistry.

GPRASP/ARMCX protein family: potential involvement in health and diseases revealed by their novel interacting partners.

F. Simonin, G. Zeder‐Lutz, S. Lecat, 2020, Current topics in medicinal chemistry.

[RF9, a powerful and selective antagonist of the neuropeptide FF receptors, prevents the development of the tolerance to opioids].

J. Bourguignon, F. Simonin, G. Simonnet, 2006, Medecine sciences : M/S.

Neuropeptide FF receptors as novel targets for limbic seizure attenuation

T. Vanhaecke, P. Boon, F. Bihel, 2015, Neuropharmacology.

Neuropeptide FF receptors as therapeutic targets

F. Simonin, 2006 .

Pharmacology letters Accelerated communication In vitro pharmacological profile of peptide III-BTD A novel ligand for nociceptin/orphanin FQ and opioid receptors

F. Simonin, G. Calo’, A. Rizzi, 2000 .

Structure-activity study of the ORL1 antagonist Ac-Arg-D-Cha-Qaa-D-Arg-D-p-ClPhe-NH2.

F. Simonin, D. Tourwé, W. Lubell, 2004, Journal of medicinal chemistry.

Antibody response and allogeneic mixed lymphocyte reaction in mu-, delta-, and kappa-opioid receptor knockout mice

D. Filliol, F. Simonin, C. Gaveriaux-Ruff, 2004, Journal of Neuroimmunology.

Probing opioid receptor interactions with azacycloalkane amino acids. Synthesis of a potent and selective ORL1 antagonist.

F. Simonin, B. Kieffer, Z. Darula, 2002, Journal of medicinal chemistry.

Effects of systematic N-terminus deletions and benzoylations of endogenous RF-amide peptides on NPFF1R, NPFF2R, GPR10, GPR54 and GPR103

F. Bihel, J. Bourguignon, F. Simonin, 2015, Peptides.

Prolactin‐releasing peptide effects in the rat brain are mediated through the Neuropeptide FF receptor

Takeshi K. Watanabe, J. Bourguignon, J. Jhamandas, 2009, The European journal of neuroscience.